Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TAPT1 Gene

protein-coding   GIFtS: 50
GCID: GC04M016162

Transmembrane Anterior Posterior Transformation 1

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Transmembrane Anterior Posterior Transformation 11 2
CMVFR2 3 5
Cytomegalovirus Partial Fusion Receptor2 3
Transmembrane Anterior Posterior Transformation Protein 1 Homolog2

External Ids:    HGNC: 268871   Entrez Gene: 2020182   Ensembl: ENSG000001697627   OMIM: 6127585   UniProtKB: Q6NXT63   

Export aliases for TAPT1 gene to outside databases

Previous GC identifers: GC04M015772 GC04M015511


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TAPT1 Gene:
This gene encodes a highly conserved, putative transmembrane protein. A mutation in the mouse ortholog of this
gene results in homeotic, posterior-to-anterior transformations of the axial skeleton which are similar to the
phenotype of mouse homeobox C8 gene mutants. This gene is proposed to function downstream of homeobox C8 to
transduce extracellular patterning information during axial skeleton development. An alternatively spliced
transcript variant encoding a substantially different isoform has been described, but its biological validity has
not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for TAPT1 Gene:
TAPT1 (transmembrane anterior posterior transformation 1) is a protein-coding gene. Diseases associated with TAPT1 include malaria. GO annotations related to this gene include growth hormone-releasing hormone receptor activity.

UniProtKB/Swiss-Prot: TAPT1_HUMAN, Q6NXT6
Function: May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular
information required for axial skeletal patterning during development (By similarity). In case of infection, may
act as a fusion receptor for cytomegalovirus (HCMV) strain AD169




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000004.12  NT_006316.17  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TAPT1 gene promoter:
         LHX3b/Lhx3b   AML1a   C/EBPalpha   Max   CHOP-10   Nkx6-1   LHX3a/Lhx3a   ARP-1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAPT1 promoter sequence
   Search Chromatin IP Primers for TAPT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAPT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p15.32   Ensembl cytogenetic band:  4p15.32   HGNC cytogenetic band: 4p15.32

TAPT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAPT1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M016162:  view genomic region     (about GC identifiers)

Start:
16,162,128 bp from pter      End:
16,229,033 bp from pter
Size:
66,906 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TAPT1_HUMAN, Q6NXT6 (See protein sequence)
Recommended Name: Transmembrane anterior posterior transformation protein 1 homolog  
Size: 567 amino acids; 64260 Da
Sequence caution: Sequence=AAF28308.1; Type=Frameshift; Positions=Several;
Secondary accessions: Q8N2S3 Q9NZK9
Alternative splicing: 2 isoforms:  Q6NXT6-1   Q6NXT6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TAPT1: NX_Q6NXT6

Explore proteomics data for TAPT1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys90, Lys388
  • Modification sites at PhosphoSitePlus

  • See TAPT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_699196.2  
    ENSEMBL proteins: 
     ENSP00000385347   ENSP00000422652   ENSP00000423359   ENSP00000422752   ENSP00000382803  
     ENSP00000305198  

    TAPT1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TAPT1
    GenScript Custom Purified and Recombinant Proteins Services for TAPT1
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TAPT1

    TAPT1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TAPT1
    Novus Biologicals TAPT1 Antibody
    Abcam antibodies for TAPT1
    Cloud-Clone Corp. Antibodies for TAPT1
    ThermoFisher Antibody for TAPT1
    LSBio Antibodies in human, mouse, rat for TAPT1

    TAPT1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TAPT1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TAPT1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TAPT1
    Cloud-Clone Corp. CLIAs for TAPT1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR008010 Membrane_Tatp1/CMV_rcpt

    Graphical View of Domain Structure for InterPro Entry Q6NXT6

    ProtoNet protein and cluster: Q6NXT6

    UniProtKB/Swiss-Prot: TAPT1_HUMAN, Q6NXT6
    Similarity: Belongs to the TAPT1 family


    TAPT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAPT1_HUMAN, Q6NXT6
    Function: May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular
    information required for axial skeletal patterning during development (By similarity). In case of infection, may
    act as a fusion receptor for cytomegalovirus (HCMV) strain AD169

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016520growth hormone-releasing hormone receptor activity TAS10640539
         
    TAPT1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TAPT1:
     Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tapt1):
     craniofacial  digestive/alimentary  hematopoietic system  mortality/aging  skeleton 

    TAPT1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tapt1tm1(KOMP)Vlcg for TAPT1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TAPT1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TAPT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TAPT1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TAPT1

    miRNA
    Products:
        
    miRTarBase miRNAs that target TAPT1:
    hsa-mir-193a-3p (MIRT044889), hsa-mir-335-5p (MIRT017563)

    Block miRNA regulation of human, mouse, rat TAPT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TAPT1 (see all 61):
    hsa-miR-579 hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-513a-5p hsa-miR-200a hsa-miR-128
    SwitchGear 3'UTR luciferase reporter plasmidTAPT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TAPT1
    Predesigned siRNA for gene silencing in human, mouse, rat TAPT1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TAPT1

    Clone
    Products:
         
    OriGene clones in human, mouse for TAPT1 (see all 7)
    OriGene ORF clones in mouse, rat for TAPT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TAPT1 (NM_153365)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAPT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAPT1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TAPT1
    Browse ESI BIO Cell Lines and PureStem Progenitors for TAPT1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAPT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TAPT1_HUMAN, Q6NXT6: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    peroxisome3
    plasma membrane3
    cytoskeleton1
    cytosol1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane TAS10640539

    TAPT1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TAPT1
    Interactions:

        Search GeneGlobe Interaction Network for TAPT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for TAPT1 (Q6NXT63 ENSP000003853474) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206286Q8N1B43I2D: score=1 
    ENSG00000224455Q8N1B43I2D: score=1 
    ENSG00000225590Q8N1B43I2D: score=1 
    ENSG00000228425Q8N1B43I2D: score=1 
    ENSG00000236014Q8N1B43I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0007186G-protein coupled receptor signaling pathway TAS10640539
    GO:0009791post-embryonic development IEA--
    GO:0048706embryonic skeletal system development IEA--

    TAPT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TAPT1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TAPT1 gene: 
    NM_153365.2  

    Unigene Cluster for TAPT1:

    Transmembrane anterior posterior transformation 1
    Hs.479223  [show with all ESTs]
    Unigene Representative Sequence: NM_153365
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000405303(uc011bxd.1 uc010ied.1 uc011bxe.1) ENST00000503858
    ENST00000505603 ENST00000513782 ENST00000508886 ENST00000507728 ENST00000488714
    ENST00000507425 ENST00000504281 ENST00000508888 ENST00000513359 ENST00000510868
    ENST00000505152 ENST00000511866 ENST00000513833 ENST00000505317(uc003gow.4)
    ENST00000511156 ENST00000399920
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TAPT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TAPT1 (see all 61):
    hsa-miR-579 hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-106a hsa-miR-513a-5p hsa-miR-200a hsa-miR-128
    SwitchGear 3'UTR luciferase reporter plasmidTAPT1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TAPT1
    Predesigned siRNA for gene silencing in human, mouse, rat TAPT1
    Clone
    Products:
         
    OriGene clones in human, mouse for TAPT1 (see all 7)
    OriGene ORF clones in mouse, rat for TAPT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TAPT1 (NM_153365)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAPT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAPT1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TAPT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TAPT1
      QuantiTect SYBR Green Assays in human, mouse, rat TAPT1
      QuantiFast Probe-based Assays in human, mouse, rat TAPT1

    Additional mRNA sequence: 

    AF189251.1 AK074494.1 AK296104.1 AK299163.1 BC066899.1 

    13 DOTS entries:

    DT.452432  DT.92424913  DT.121240425  DT.437131  DT.99997998  DT.92424915  DT.95334735  DT.100751767 
    DT.100751768  DT.91753937  DT.91824045  DT.97802640  DT.91925032 

    Selected AceView cDNA sequences (see all 130):

    BQ006492 AA811306 AA652990 BF793455 BQ221946 AW117403 AI130017 BQ638907 
    BQ215133 CA413080 BP346181 AA463729 NM_153365 AK074494 AW976422 BQ016102 
    BQ774525 AI032195 BU631873 BG057678 AW297714 AW006940 BC066899 BM457357 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TAPT1 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b · 18c
    SP1:        -                 -           -                                   -                 -           -                 -                                 
    SP2:                          -           -                                                                                                                     
    SP3:                                                                                                                                                            
    SP4:                                                                                                        -           -     -                                 
    SP5:                                                                                                                    -     -                                 


    ECgene alternative splicing isoforms for TAPT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TAPT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCCTGGAG
    TAPT1 Expression
    About this image


    TAPT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Bone (Muscoskeletal System)
             Bone Marrow
    TAPT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TAPT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.479223
        Custom PCR Arrays for TAPT1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TAPT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TAPT1
    QuantiTect SYBR Green Assays in human, mouse, rat TAPT1
    QuantiFast Probe-based Assays in human, mouse, rat TAPT1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAPT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TAPT1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tapt11 , 5 transmembrane anterior posterior transformation 11, 5 90.01(n)1
    95.21(a)1
      5 (24.24 cM)5
    2312251  NM_173764.31  NP_776125.21 
     441751645 
    chicken
    (Gallus gallus)
    Aves TAPT11 transmembrane anterior posterior transformation 1 82.85(n)
    89.64(a)
      422824  NM_001031161.2  NP_001026332.2 
    lizard
    (Anolis carolinensis)
    Reptilia TAPT16
    transmembrane anterior posterior transformation 1
    91(a)
    1 ↔ 1
    GL343458.1(51039-123787)
    African clawed frog
    (Xenopus laevis)
    Amphibia BU901883.12   -- 80.18(n)    BU901883.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tapt11 Transmembrane anterior posterior transformation protein more 73.37(n)
    82.76(a)
      559710  NM_001123250.1  NP_001116722.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG72181 CG7218 53.63(n)
    48.79(a)
      42165  NM_142421.3  NP_650678.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F26F2.71 F26F2.7 57.47(n)
    51.46(a)
      180347  NM_075571.4  NP_507972.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YER140W)4 Putative protein of unknown function; the authentic, more   --   5(451565-453235) 856883  NP_011067.1 


    ENSEMBL Gene Tree for TAPT1 (if available)
    TreeFam Gene Tree for TAPT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TAPT1 (see all 1686)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs131360551,2
    C--15577985(+) CGGTCC/TGCTCA 1 -- int13Minor allele frequency- T:0.33NA EA 242
    rs1473609281,2
    C--15578088(+) CTCCAC/GATCAC 1 -- int10--------
    rs1449745651,2
    --15578437(+) CCGCAA/GCGAGC 1 -- int10--------
    rs1866296051,2
    --15578552(+) CCGGTA/GAGGGG 1 -- int10--------
    rs1914352471,2
    C--15578587(+) TGCCAC/GCTTCG 1 -- int10--------
    rs1854422091,2
    --15578857(+) AATGTC/TCCAGC 1 -- int10--------
    rs1891162091,2
    --15578871(+) TGGGAA/GCCCAA 1 -- int10--------
    rs1931318191,2
    --15579144(+) CCCATA/TTTCTA 1 -- int10--------
    rs1479283311,2
    --15579207(+) ATTGTC/TAAGAA 1 -- int10--------
    rs1851870311,2
    --15579236(+) CTATTC/TTTATG 1 -- int10--------

    HapMap Linkage Disequilibrium report for TAPT1 (16162128 - 16229033 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TAPT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2727223CNV Deletion23290073
    nsv4246CNV Insertion18451855
    esv24752CNV Loss19812545
    nsv878720CNV Loss21882294
    nsv527861CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TAPT1
    DNA2.0 Custom Variant and Variant Library Synthesis for TAPT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 612758    OMIM disorders: --

    1 disease for TAPT1:    
    About MalaCards
    malaria


    TAPT1 for disorders           About GeneDecksing


    Export disorders for TAPT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TAPT1 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with TAPT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. Cloning and epitope mapping of a functional partial fusion receptor for human cytomegalovirus gH. (PubMed id 10640539)1, 2 Baldwin B.R.... Keay S. (J. Gen. Virol. 2000)
    4. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (Sci. Signal. 2009)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)
    9. Mutation of a ubiquitously expressed mouse transmembrane protein (Tapt1) causes specific skeletal homeotic transformations. (PubMed id 17151244)1 Howell G.R....Schimenti J.C. (Genetics 2007)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 202018 HGNC: 26887 AceView: FLJ90013 Ensembl:ENSG00000169762 euGenes: HUgn202018
    ECgene: TAPT1 H-InvDB: TAPT1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TAPT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TAPT1 gene:
    Search GeneIP for patents involving TAPT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TAPT1  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TAPT1  
     OriGene qSTAR qPCR primer pairs in human, mouse for TAPT1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TAPT1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TAPT1   OriGene Custom Protein Services for TAPT1  

     
     
     Block miRNA regulation of human, mouse, rat TAPT1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TAPT1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAPT1 Predesigned siRNA for gene silencing in human, mouse, rat TAPT1
     QuantiFast Probe-based Assays in human, mouse, rat TAPT1 QuantiTect SYBR Green Assays in human, mouse, rat TAPT1
     Custom PCR Arrays for TAPT1 Search Chromatin IP Primers for TAPT1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TAPT1  Search GeneGlobe Interaction Network for TAPT1
     Regulatory tfbs in TAPT1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TAPT1 GenScript cDNA clones with any tag delivered in your preferred vector for TAPT1
     GenScript Custom Assay Services for TAPT1 GenScript Custom overexpressing Cell Line Services for TAPT1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TAPT1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TAPT1 antibodies
     Antibodies for TAPT1
     See all of Abcam's Antibodies, Kits and Proteins for TAPT1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TAPT1
     Antibodies for TAPT1
     ELISAs for TAPT1
     CLIAs for TAPT1



     Browse ESI BIO Cell Lines and PureStem Progenitors for TAPT1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAPT1
     SwitchGear 3'UTR luciferase reporter plasmids for TAPT1
     SwitchGear Promoter luciferase reporter plasmids for TAPT1
     ThermoFisher Antibody for TAPT1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAPT1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TAPT1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TAPT1
     LSBio Antibodies in human, mouse, rat for TAPT1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TAPT1 gene at Home site.
    Version: 3.12.164 25 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4