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Aliases for TAPT1 Gene

Aliases for TAPT1 Gene

  • Transmembrane Anterior Posterior Transformation 1 2 3
  • CMVFR 3 4 6
  • Cytomegalovirus Partial Fusion Receptor 3 4
  • Transmembrane Anterior Posterior Transformation Protein 1 Homolog 3

External Ids for TAPT1 Gene

Summaries for TAPT1 Gene

Entrez Gene Summary for TAPT1 Gene

  • This gene encodes a highly conserved, putative transmembrane protein. A mutation in the mouse ortholog of this gene results in homeotic, posterior-to-anterior transformations of the axial skeleton which are similar to the phenotype of mouse homeobox C8 gene mutants. This gene is proposed to function downstream of homeobox C8 to transduce extracellular patterning information during axial skeleton development. An alternatively spliced transcript variant encoding a substantially different isoform has been described, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAPT1 Gene

TAPT1 (Transmembrane Anterior Posterior Transformation 1) is a Protein Coding gene. GO annotations related to this gene include growth hormone-releasing hormone receptor activity.

UniProtKB/Swiss-Prot for TAPT1 Gene

  • May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). In case of infection, may act as a fusion receptor for cytomegalovirus (HCMV) strain AD169.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAPT1 Gene

Genomics for TAPT1 Gene

Genomic Location for TAPT1 Gene

Start:
16,160,505 bp from pter
End:
16,227,410 bp from pter
Size:
66,906 bases
Orientation:
Minus strand

Genomic View for TAPT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAPT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAPT1 Gene

Regulatory Elements for TAPT1 Gene

Proteins for TAPT1 Gene

  • Protein details for TAPT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NXT6-TAPT1_HUMAN
    Recommended name:
    Transmembrane anterior posterior transformation protein 1 homolog
    Protein Accession:
    Q6NXT6
    Secondary Accessions:
    • Q8N2S3
    • Q9NZK9

    Protein attributes for TAPT1 Gene

    Size:
    567 amino acids
    Molecular mass:
    64260 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF28308.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

    Alternative splice isoforms for TAPT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAPT1 Gene

Proteomics data for TAPT1 Gene at MOPED

Post-translational modifications for TAPT1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys90 and Lys388

Other Protein References for TAPT1 Gene

No data available for DME Specific Peptides for TAPT1 Gene

Domains for TAPT1 Gene

Protein Domains for TAPT1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TAPT1_HUMAN
Family:
  • Belongs to the TAPT1 family.:
    • Q6NXT6
genes like me logo Genes that share domains with TAPT1: view

No data available for Gene Families for TAPT1 Gene

Function for TAPT1 Gene

Molecular function for TAPT1 Gene

UniProtKB/Swiss-Prot Function: May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). In case of infection, may act as a fusion receptor for cytomegalovirus (HCMV) strain AD169.

Gene Ontology (GO) - Molecular Function for TAPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016520 growth hormone-releasing hormone receptor activity TAS 10640539
genes like me logo Genes that share ontologies with TAPT1: view
genes like me logo Genes that share phenotypes with TAPT1: view

miRNA for TAPT1 Gene

miRTarBase miRNAs that target TAPT1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TAPT1 Gene

Localization for TAPT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAPT1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAPT1 Gene COMPARTMENTS Subcellular localization image for TAPT1 gene
Compartment Confidence
peroxisome 3
plasma membrane 3
cytoskeleton 1
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TAPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane TAS 10640539
genes like me logo Genes that share ontologies with TAPT1: view

Pathways for TAPT1 Gene

SuperPathways for TAPT1 Gene

No Data Available

Interacting Proteins for TAPT1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000385347%0d%0a9606.ENSP00000263688%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000385347 Q6NXT6-TAPT1_HUMAN for TAPT1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TAPT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS 10640539
GO:0009791 post-embryonic development IEA --
GO:0048706 embryonic skeletal system development IEA --
genes like me logo Genes that share ontologies with TAPT1: view

No data available for Pathways by source for TAPT1 Gene

Transcripts for TAPT1 Gene

Unigene Clusters for TAPT1 Gene

Transmembrane anterior posterior transformation 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAPT1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b · 18c
SP1: - - - - - - -
SP2: - -
SP3:
SP4: - - -
SP5: - -
SP6:
SP7:

Relevant External Links for TAPT1 Gene

GeneLoc Exon Structure for
TAPT1
ECgene alternative splicing isoforms for
TAPT1

Expression for TAPT1 Gene

mRNA expression in normal human tissues for TAPT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TAPT1 Gene

SOURCE GeneReport for Unigene cluster for TAPT1 Gene Hs.479223

genes like me logo Genes that share expressions with TAPT1: view

Orthologs for TAPT1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAPT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAPT1 36
  • 99.47 (n)
  • 99.82 (a)
TAPT1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAPT1 36
  • 87.2 (n)
  • 93.8 (a)
TAPT1 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAPT1 36
  • 92.18 (n)
  • 94.85 (a)
TAPT1 37
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tapt1 36
  • 90.01 (n)
  • 95.21 (a)
Tapt1 16
Tapt1 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAPT1 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 95 (a)
OneToMany
-- 37
  • 84 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tapt1 36
  • 90.49 (n)
  • 97.01 (a)
chicken
(Gallus gallus)
Aves TAPT1 36
  • 82.85 (n)
  • 89.64 (a)
TAPT1 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAPT1 37
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tapt1 36
  • 76.15 (n)
  • 84.23 (a)
zebrafish
(Danio rerio)
Actinopterygii tapt1 36
  • 73.37 (n)
  • 82.76 (a)
TAPT1 (2 of 2) 37
  • 70 (a)
OneToMany
tapt1b 37
  • 77 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002775 36
  • 55.8 (n)
  • 54.9 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7218 36
  • 53.63 (n)
  • 48.79 (a)
CG7218 37
  • 35 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F26F2.7 36
  • 57.47 (n)
  • 51.46 (a)
F26F2.7 37
  • 30 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 58 (a)
OneToOne
Species with no ortholog for TAPT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAPT1 Gene

ENSEMBL:
Gene Tree for TAPT1 (if available)
TreeFam:
Gene Tree for TAPT1 (if available)

Paralogs for TAPT1 Gene

No data available for Paralogs for TAPT1 Gene

Variants for TAPT1 Gene

Sequence variations from dbSNP and Humsavar for TAPT1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs7359 -- 16,162,866(-) TCAAA(C/T)GTTAC utr-variant-3-prime, nc-transcript-variant
rs9946 -- 16,161,598(-) TTAGA(A/G)TTATT utr-variant-3-prime, nc-transcript-variant
rs13634 -- 16,161,586(-) TTTCC(A/G)TCTCC utr-variant-3-prime, nc-transcript-variant
rs178450 -- 16,179,947(+) TCAGA(C/T)GAGGT intron-variant
rs317852 -- 16,164,028(-) TTTTG(A/T)TTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAPT1 Gene

Variant ID Type Subtype PubMed ID
nsv527861 CNV Gain 19592680
nsv4246 CNV Insertion 18451855
esv2727223 CNV Deletion 23290073
nsv878720 CNV Loss 21882294
esv24752 CNV Loss 19812545

Relevant External Links for TAPT1 Gene

HapMap Linkage Disequilibrium report
TAPT1

Disorders for TAPT1 Gene

No disorders were found for TAPT1 Gene.

No data available for UniProtKB/Swiss-Prot for TAPT1 Gene

Publications for TAPT1 Gene

  1. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  2. Mutation of a ubiquitously expressed mouse transmembrane protein (Tapt1) causes specific skeletal homeotic transformations. (PMID: 17151244) Howell G.R. … Schimenti J.C. (Genetics 2007) 2 3
  3. Cloning and epitope mapping of a functional partial fusion receptor for human cytomegalovirus gH. (PMID: 10640539) Baldwin B.R. … Keay S. (J. Gen. Virol. 2000) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Molecular cloning and expression of receptor peptides that block human cytomegalovirus/cell fusion. (PMID: 8605045) Baldwin B.R. … Keay S. (Biochem. Biophys. Res. Commun. 1996) 3

Products for TAPT1 Gene

Sources for TAPT1 Gene

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