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Aliases & Descriptions for TAPT1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| CMVFR 2, 3, 5 | | FLJ90013 1, 2 |
| | | Descriptions |
|---|
| Cytomegalovirus partial fusion receptor 2, 3 | | transmembrane anterior posterior transformation 1 2 |
|
| | Search outside databases for aliases for TAPT1 gene |
Summaries for TAPT1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for TAPT1: This gene encodes a highly conserved, putative transmembrane protein. A mutation in the mouse ortholog of this gene results in homeotic, posterior-to-anterior transformations of the axial skeleton which are similar to the phenotype of mouse homeobox C8 gene mutants. This gene is proposed to function downstream of homeobox C8 to transduce extracellular patterning information during axial skeleton development. An alternatively spliced transcript variant encoding a substantially different isoform has been described, but its biological validity has not been determined. [provided by RefSeq] UniProtKB/Swiss-Prot: TAPT1_HUMAN, Q6NXT6Function: May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). In case of infection, may act as a fusion receptor for cytomegalovirus (HCMV) strain AD169 |
Genomic Location for TAPT1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p15.32 Ensembl cytogenetic band: 4p15.32 HGNC cytogenetic band: 4p15.32TAPT1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M015772:
(about GC identifiers)
Start:
|
15,771,226 bp from pter |
End:
|
15,837,259 bp from pter |
Size:
|
66,034 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000004.10 NT_006316.15
| Proteins for TAPT1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: TAPT1_HUMAN, Q6NXT6 (See
protein sequence)Recommended Name: Transmembrane anterior posterior transformation protein 1 homolog Size: 567 amino acids; 64260 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAF28308.1; Type=Frameshift; Positions=Several;
Secondary accessions: Q8N2S3 Q9NZK9Alternative splicing: 2 isoforms: Q6NXT6-1 Q6NXT6-2 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_699196.2
ENSEMBL proteins: ENSP00000382803 ENSP00000385347 ENSP00000305198
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016020 | membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- | About this table
Antibodies for TAPT1: Assays for TAPT1: | Protein
Domains/ Families for TAPT1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q6NXT6
ProtoNet protein and cluster: Q6NXT6 UniProtKB/Swiss-Prot: TAPT1_HUMAN, Q6NXT6Similarity: Belongs to the TAPT1 family | Gene Function for TAPT1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_153365
Applied Biosystems Silencer® siRNAs for TAPT1
Sigma-Aldrich siRNA for TAPT1  Sigma-Aldrich shRNA for TAPT1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_153365                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_153365                                  untagged cDNA clones in CMV expression vector (see all 3): NM_153365 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_153365
UniProtKB/Swiss-Prot: TAPT1_HUMAN, Q6NXT6Function: May act as a downstream effector of HOXC8 possibly by transducing or transmitting extracellular information required for axial skeletal patterning during development (By similarity). In case of infection, may act as a fusion receptor for cytomegalovirus (HCMV) strain AD1692 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Tapt1):
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004872 | receptor activity |
IEA | -- | About this table | Pathways & Interactions for TAPT1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| --1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007275 | multicellular organismal development |
IEA | -- | About this table
|
Drugs & Compounds for TAPT1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for TAPT1
|
Transcripts for TAPT1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_153365
Sigma-Aldrich siRNA for TAPT1  Sigma-Aldrich shRNA for TAPT1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_153365 REFSEQ mRNAs for TAPT1 gene: NM_153365.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_153365               OriGene GFP tagged cDNA clone in CMV expression vector: NM_153365                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_153365                                  untagged cDNA clones in CMV expression vector (see all 3): NM_153365  Additional cDNA sequence: AF189251.1 AK074494.1 AK296104.1 AK299163.1 BC066899.1 12 DOTS entries: DT.92424913 DT.452432 DT.121240425 DT.437131 DT.91925032 DT.92424915 DT.95334735 DT.100751767 DT.100751768 DT.91753937 DT.91824045 DT.97802640 24/130 AceView cDNA sequences (see all 130
):AA463729 BQ016102 BF793455 NM_153365 BQ215133 AW117403 AK074494 CA413080 AA811306 BC066899 BQ006492 AI130017 AI032195 AW976422 BQ638907 BQ221946 BP346181 BM457357 AW006940 BG057678 AA652990 BQ774525 AW297714 BU631873
highest scoring ESTs for TAPT1:BC066899 R15368 AA193348 AA193466 AA287444 AA397807 AA503530 AA687414 AA748665 AF189251 Unigene Cluster for TAPT1: Transmembrane anterior posterior transformation 1 Hs.479223 [show with all ESTs]Unigene Representative Sequence: NM_153365
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TAPT1 (see all 7
)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16 | ^ | 17a | · | 17b | · | 17c | ^ | 18a | · | 18b | · | 18c | |
| SP1: | |   | - |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for TAPT1
3 Ensembl transcripts including schematic representations: ENST00000399920
ENST00000405303
ENST00000304584
|
Expression for TAPT1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| TAPT1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for TAPT1
1 / 2 / 3 13 probe-sets matching TAPT1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AACCCTGGAG
SOURCE GeneReport for Unigene cluster: Hs.479223
|
Orthologs for TAPT1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TAPT1 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for TAPT1
ENSEMBL Gene Tree for TAPT1 | Paralogs for TAPT1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for TAPT1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for TAPT1 (up to first 250kb)
|
Disorders & Mutations for TAPT1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 612758
|
Medical News for TAPT1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for TAPT1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 6 PubMed articles for TAPT1 gene: |
Search for TAPT1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TAPT1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing TAPT1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TAPT1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for TAPT1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for TAPT1:

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| | | | Search Tocris compounds for TAPT1 |
|
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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