TAPBPL Gene
protein-coding GIFtS : 46
GCID: GC12 P006561
TAP binding protein-like
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Aliasesfor TAPBPL gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases TAP Binding Protein-Like 1 2 FLJ101431 TAPBP-R1 2 3 TAP Binding Protein Related2 TAPBPR1 2 5 Tapasin-Like1 TAPASIN-R2 3 Tapasin-Related Protein2 TAP-Binding Protein-Like2 3 Tapasin-Like1 TAP-Binding Protein-Related Protein2 3
Export aliases for TAPBPL gene to outside databases Previous GC identifers: GC12P006432 GC12P006434
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Summariesfor TAPBPL gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for TAPBPL : Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3. TAPBPL is a member of the Ig superfamily that is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC.(supplied by OMIM, Mar 2008)
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Genomic Viewsfor TAPBPL gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000012.11 NC_018923.1 NT_009759.16 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TAPBPL gene promoter: GR AML1a AP-1 p53 GR-beta HSF1 (long) HSF1short GR-alpha Other transcription factors Search SABiosciences Chromatin IP Primers for TAPBPL Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAPBPL
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 12p13.31 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13.31 TAPBPL Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12P006561: view genomic region
(about GC identifiers )
Start:
6,560,856 bp from pter
End:
6,575,683 bp from pter
Size:
14,828 bases
Orientation:
plus strand
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Proteinsfor TAPBPL gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: TPSNR_HUMAN, Q9BX59 (See
protein sequence )Recommended Name: Tapasin-related protein precursor Size : 468 amino acids; 50183 Da
Subcellular location : Cell membrane; Single-pass type I membrane protein (Probable). Endoplasmic reticulum membrane;Single-pass type I membrane protein (Probable). Microsome membrane; Single-pass type I membrane protein (Probable). Note=Mainly found in endoplasmic reticulum but a minority is found on the cell surface
Secondary accessions : Q9NWB8Explore the universe of human proteins at neXtProt for TAPBPL: NX_Q9BX59 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q9BX59 TAPBPL Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_060479.3 ENSEMBL proteins: ENSP00000445341 ENSP00000266556 Human Recombinant Protein Products: Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view) : About this table
TAPBPL for ontologies About GeneDecksing TAPBPL Antibody Products: Assay Products for TAPBPL:
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Protein
Domains / Familiesfor TAPBPL gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TAPBPL for domains About GeneDecksing 5/7 InterPro domains/families (see all 7 ):
Graphical View of Domain Structure for InterPro Entry Q9BX59 ProtoNet protein and cluster: Q9BX59
2 Blocks protein families : IPB003597 Immunoglobulin C-type IPB013106 Immunoglobulin V-set UniProtKB/Swiss-Prot: TPSNR_HUMAN, Q9BX59 Similarity : Contains 1 Ig-like C1-type (immunoglobulin-like) domainSimilarity : Contains 1 Ig-like V-type (immunoglobulin-like) domain
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Functionfor TAPBPL gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TAPBPL (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TAPBPLOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TAPBPL (NM_018009 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAPBPL Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TAPBPL
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAPBPL
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Pathways & Interactionsfor TAPBPL gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAPBPL STRING Interaction
Network Preview (showing 5 interactants - click image to see 15)5/15 Interacting proteins for TAPBPL (ENSP00000266556 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 15 )About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
IEA --
TAPBPL for ontologies About GeneDecksing
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Drugs & Compoundsfor TAPBPL gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TAPBPL Search CenterWatch for drugs/clinical trials and news about TAPBPL / TPSNR
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Transcriptsfor TAPBPL gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TAPBPL gene: NM_018009.4 Unigene Cluster for TAPBPL:
TAP binding protein-like Hs.504597 [show with all ESTs ] Unigene Representative Sequence: AK098035 8 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000539384 ENST00000544826 ENST00000544021 ENST00000266556 (uc001qog.4 )ENST00000545700 (uc001qoi.1 ) ENST00000543567 ENST00000542160 ENST00000544289 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TAPBPL (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TAPBPLOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: TAPBPL (NM_018009 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAPBPL Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TAPBPL
Additional cDNA sequence: AK001005.1 AK002056.2 AK098035.1 AK222956.1 AK223163.1 BC015017.2
22 DOTS entries : DT.92438464 DT.97862728
DT.100642876 DT.121214676 DT.121214743 DT.95334218 DT.100640107 DT.121214734 DT.317661 DT.95334214 DT.95170259 DT.121214753 DT.40312062 DT.95334217 DT.121214669 DT.92017844 DT.95334167 DT.100772134 DT.91686927 DT.92438467 DT.92438468 DT.95334215 9 AceView cDNA sequences :
CR598232 CR604472 CR594087 CR622967 AK098035 NM_018009 AK001005 BC015017 AK002056 GeneLoc Exon Structure
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Expression for TAPBPL gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TAPBPL expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: ACATTGGTAA
About this image TAPBPL expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category PureStem™ progenitor W8 (Embryonic Progenitor Cell)Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See TAPBPL Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TAPBPL SOURCE GeneReport for Unigene cluster: Hs.504597 SABiosciences Custom PCR Arrays for TAPBPL Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TAPBPLBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat TAPBPL QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TAPBPL QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TAPBPL In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAPBPL
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Orthologsfor TAPBPL gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for TAPBPL gene from 3/8 species (see all 8 ) About this table
ENSEMBL Gene Tree for TAPBPL (if available)TreeFam Gene Tree for TAPBPL (if available)
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Paralogsfor TAPBPL gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for TAPBPL gene TAPBP 2
TAPBPL for paralogs About GeneDecksing
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Genomic Variantsfor TAPBPL gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 12 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TAPBPL (6560856 - 6575683 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 7 variations for TAPBPL 7 CNVs : 3872 8706 2967 9679 30577 8705 37679
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TAPBPL
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Disorders
/ Diseasesfor TAPBPL gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
TAPBPL for disorders About GeneDecksing
OMIM gene information: 607081
OMIM disorders : --3 diseases for TAPBPL : About MalaCards esophageal cancer alzheimer's disease esophagitis Human Genome Epidemiology (HuGE) Navigator: TAPBPL (4 documents) Export disorders for TAPBPL gene to outside databases
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Publicationsfor TAPBPL gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TAPBPL gene, integrated from 9 sources (see all 13 ): (articles sorted by number of sources associating them with TAPBPL) Utopia : connect your pdf to the dynamic world of online information
A human TAPBP (TAPASIN)-related gene, TAPBP-R. (PubMed id 11920573) 1 , 2 , 3, 9 Teng M.S....Trowsdale J. (2002) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161) 1 , 2 Zhang Z. and Henzel W.J. (2004) Association of defective HLA-I expression with antige n processing machinery and their association with clinicopathological character istics in Kazak patients with esophageal cancer. (PubMed id 21362330) 1 Ayshamgul H....Abulizi A. (2011) Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726) 1 Chapuis J....Lambert J.C. (2009) Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279) 1 Hosgood H.D....Lan Q. (2009) Further examination of the candidate genes in chromosome 12p13 locus for late-onset Alzheimer disease. (PubMed id 18340469) 1 Lee J.H....Mayeux R. (2008) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) The finished DNA sequence of human chromosome 12. (PubMed id 16541075) 2 Scherer S.E.... Gibbs R.A. (2006)
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External Searches for TAPBPL gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TAPBPL gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TAPBPL gene
(According to HUGE )
About This Section --
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Specialized Databases showing TAPBPL gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TAPBPL Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TAPBPL gene: Search GeneIP for patents involving TAPBPL GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TAPBPL gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for TAPBPL OriGene shRNA RFP for TAPBPL OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TAPBPL OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TAPBPL OriGene Protein Over-expression Lysate for TAPBPL Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TAPBPL OriGene 3'-UTR Clone for TAPBPL OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TAPBPL OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TAPBPL Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for TAPBPL OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TAPBPL OriGene Custom Protein Services for TAPBPL OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TAPBPL QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing TAPBPL QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAPBPL QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TAPBPL QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TAPBPL QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TAPBPL
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TAPBPL Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAPBPL
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TAPBPL
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