Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TAPBPL Gene

Aliases for TAPBPL Gene

  • TAP Binding Protein-Like 2 3
  • TAP-Binding Protein-Related Protein 3 4
  • TAP-Binding Protein-Like 3 4
  • Tapasin-Like 3 4
  • TAPASIN-R 3 4
  • TAPBP-R 3 4
  • TAPBPR 3 6
  • TAP Binding Protein Related 3
  • Tapasin-Related Protein 3

External Ids for TAPBPL Gene

Summaries for TAPBPL Gene

Entrez Gene Summary for TAPBPL Gene

  • Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3. TAPBPL is a member of the Ig superfamily that is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC.[supplied by OMIM, Mar 2008]

GeneCards Summary for TAPBPL Gene

TAPBPL (TAP Binding Protein-Like) is a Protein Coding gene. Diseases associated with TAPBPL include esophageal cancer. An important paralog of this gene is TAPBP.

UniProtKB/Swiss-Prot for TAPBPL Gene

  • Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAPBPL Gene

Genomics for TAPBPL Gene

Genomic Location for TAPBPL Gene

Start:
6,451,690 bp from pter
End:
6,466,517 bp from pter
Size:
14,828 bases
Orientation:
Plus strand

Genomic View for TAPBPL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAPBPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAPBPL Gene

Regulatory Elements for TAPBPL Gene

Proteins for TAPBPL Gene

  • Protein details for TAPBPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BX59-TPSNR_HUMAN
    Recommended name:
    Tapasin-related protein
    Protein Accession:
    Q9BX59
    Secondary Accessions:
    • Q9NWB8

    Protein attributes for TAPBPL Gene

    Size:
    468 amino acids
    Molecular mass:
    50183 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TAPBPL Gene

neXtProt entry for TAPBPL Gene

Proteomics data for TAPBPL Gene at MOPED

Post-translational modifications for TAPBPL Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Thr254

Other Protein References for TAPBPL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAPBPL Gene

Domains for TAPBPL Gene

Gene Families for TAPBPL Gene

HGNC:
  • C1SET :Immunoglobulin superfamily / C1-set domain containing

Protein Domains for TAPBPL Gene

UniProtKB/Swiss-Prot:

TPSNR_HUMAN
Domain:
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.:
    • Q9BX59
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • Q9BX59
genes like me logo Genes that share domains with TAPBPL: view

Function for TAPBPL Gene

Molecular function for TAPBPL Gene

UniProtKB/Swiss-Prot Function: Component of the antigen processing and presentation pathway, which binds to MHC class I coupled with beta2-microglobulin/B2M. Association between TAPBPR and MHC class I occurs in the absence of a functional peptide-loading complex (PLC). Expression seems to slow down and down-regulate MHC class I surface expression.
UniProtKB/Swiss-Prot Induction: By interferon gamma.

Gene Ontology (GO) - Molecular Function for TAPBPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0032403 protein complex binding IPI 23401559
genes like me logo Genes that share ontologies with TAPBPL: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TAPBPL Gene

Localization for TAPBPL Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAPBPL Gene

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Microsome membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Note=Mainly found in endoplasmic reticulum but a minority is found on the cell surface.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAPBPL Gene COMPARTMENTS Subcellular localization image for TAPBPL gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 5
extracellular 2
golgi apparatus 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TAPBPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TAPBPL: view

Pathways for TAPBPL Gene

SuperPathways for TAPBPL Gene

No Data Available

Interacting Proteins for TAPBPL Gene

Gene Ontology (GO) - Biological Process for TAPBPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0002590 negative regulation of antigen processing and presentation of peptide antigen via MHC class I IDA 23401559
genes like me logo Genes that share ontologies with TAPBPL: view

No data available for Pathways by source for TAPBPL Gene

Transcripts for TAPBPL Gene

mRNA/cDNA for TAPBPL Gene

Unigene Clusters for TAPBPL Gene

TAP binding protein-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAPBPL Gene

No ASD Table

Relevant External Links for TAPBPL Gene

GeneLoc Exon Structure for
TAPBPL
ECgene alternative splicing isoforms for
TAPBPL

Expression for TAPBPL Gene

mRNA expression in normal human tissues for TAPBPL Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAPBPL Gene

SOURCE GeneReport for Unigene cluster for TAPBPL Gene Hs.504597

genes like me logo Genes that share expressions with TAPBPL: view

Orthologs for TAPBPL Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAPBPL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAPBPL 36
  • 98.86 (n)
  • 99.15 (a)
TAPBPL 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAPBPL 36
  • 80.93 (n)
  • 75.65 (a)
TAPBPL 37
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAPBPL 36
  • 80.43 (n)
  • 71.01 (a)
TAPBPL 37
  • 54 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tapbpl 36
  • 78.04 (n)
  • 70.53 (a)
Tapbpl 16
Tapbpl 37
  • 67 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 19 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TAPBPL 37
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tapbpl 36
  • 78.27 (n)
  • 71.93 (a)
chicken
(Gallus gallus)
Aves TAPBPL 36
  • 57.82 (n)
  • 45.66 (a)
TAPBPL 37
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tapbpl 36
  • 49.39 (n)
  • 37.17 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100150889 36
  • 51.3 (n)
  • 42.59 (a)
tapbpl 37
  • 30 (a)
OneToOne
Species with no ortholog for TAPBPL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAPBPL Gene

ENSEMBL:
Gene Tree for TAPBPL (if available)
TreeFam:
Gene Tree for TAPBPL (if available)

Paralogs for TAPBPL Gene

Paralogs for TAPBPL Gene

genes like me logo Genes that share paralogs with TAPBPL: view

Variants for TAPBPL Gene

Sequence variations from dbSNP and Humsavar for TAPBPL Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1045546 - 6,458,741(-) TCCAC(A/G)TCACC reference, missense, nc-transcript-variant
rs2009527 -- 6,460,379(+) TCCCA(C/T)CTCAG intron-variant
rs2041387 -- 6,453,657(+) TGAGG(C/T)GCTCT reference, missense, nc-transcript-variant
rs2041388 -- 6,453,670(+) CACCC(A/G)ACGCT synonymous-codon, reference, nc-transcript-variant
rs2079866 -- 6,454,682(+) TTTCT(C/G)CCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAPBPL Gene

Variant ID Type Subtype PubMed ID
esv34325 CNV Gain 17911159
dgv453e1 CNV Complex 17122850
esv34390 CNV Gain 17911159
essv12131 CNV CNV 17122850
nsv818881 CNV Gain 17921354
nsv442252 CNV CNV 18776908
nsv8894 CNV Gain 18304495
nsv525022 CNV Gain 19592680

Relevant External Links for TAPBPL Gene

HapMap Linkage Disequilibrium report
TAPBPL

Disorders for TAPBPL Gene

(1) MalaCards Diseases for TAPBPL Gene

Search for TAPBPL Gene in MalaCards »

Relevant External Links for TAPBPL

Genetic Association Database (GAD)
TAPBPL
Human Genome Epidemiology (HuGE) Navigator
TAPBPL
genes like me logo Genes that share disorders with TAPBPL: view

No data available for UniProtKB/Swiss-Prot for TAPBPL Gene

Publications for TAPBPL Gene

  1. A human TAPBP (TAPASIN)-related gene, TAPBP-R. (PMID: 11920573) Teng M.S. … Trowsdale J. (Eur. J. Immunol. 2002) 2 3 4 23
  2. Tapasin-related protein TAPBPR is an additional component of the MHC class I presentation pathway. (PMID: 23401559) Boyle L.H. … Trowsdale J. (Proc. Natl. Acad. Sci. U.S.A. 2013) 3 4
  3. TAPBPR isoforms exhibit altered association with MHC class I. (PMID: 24444341) Porter K.M. … Boyle L.H. (Immunology 2014) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PMID: 15340161) Zhang Z. … Henzel W.J. (Protein Sci. 2004) 3 4

Products for TAPBPL Gene

Sources for TAPBPL Gene

Back to Top

Content