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TAPBPL Gene

protein-coding   GIFtS: 51

GC12P006434
TAP binding protein-like
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ10143 1, 2
TAPASIN-R 3
TAPBP-R 1, 2, 3
TAPBPR 1, 2
Tapasin-like 3
Descriptions
TAP binding protein related 2
TAP binding protein-like 2
TAP-binding protein-like 3
TAP-binding protein-related protein 3
External Ids
HGNC: 306831
Entrez Gene: 550802
UniProtKB: Q9BX593
Ensembl: ENSG000001391927
Search outside databases for aliases for TAPBPL gene

Previous GC identifer: GC12P006432

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for TAPBPL:
Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links
major histocompatibility complex (MHC) class I molecules to the transporter associated with
antigen processing (TAP; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is
located near the MHC complex on chromosome 6p21.3. TAPBPL is a member of the Ig superfamily that
is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC.[supplied by OMIM]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the TAPBPL gene  

Entrez Gene cytogenetic band: 12p13.31   Ensembl cytogenetic band:  12p13.31   HGNC cytogenetic band: 12p13.31

TAPBPL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P006434:     (about GC identifiers)

Start:
6,431,438 bp from pter
End:
6,441,749 bp from pter
Size:
10,312 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000012.10  NT_009759.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TPSNR_HUMAN, Q9BX59 (See protein sequence)
Recommended Name: Tapasin-related protein precursor  
Size: 468 amino acids; 50177 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein (Probable). Endoplasmic
reticulum membrane; Single-pass type I membrane protein (Probable). Microsome membrane;
Single-pass type I membrane protein (Probable). Note=Mainly found in endoplasmic reticulum but a
minority is found on the cell surface
Secondary accessions: Q9NWB8

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_060479.3  

    ENSEMBL proteins: 
    ENSP00000266556 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Tapasin Related Protein)
    Human Recombinant Proteins from Abnova (TAPBPL)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783 endoplasmic reticulum IEA--
    GO:0005789 endoplasmic reticulum membrane IEA--
    GO:0005792 microsome IEA--
    GO:0005886 plasma membrane IEA--
    GO:0016021 integral to membrane IEA--
    About this table

    Antibodies for TAPBPL: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for TAPBPL
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (Tapasin Related Protein), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (TAPBPL)
    Novus Biologicals Antibodies for TAPBPL

    Assays for TAPBPL: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5/7 InterPro domains/families (see all 7 ):
     IPR007110 Ig-like
     IPR003006 Ig/MHC_CS
     IPR003599 Ig_sub
     IPR008056 Tapasin
     IPR013783 Ig-like_fold


       GeneDecks  TAPBPL for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9BX59

    ProtoNet protein and cluster: Q9BX59

    2 Blocks protein families:
    IPB003597 Immunoglobulin C-type
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: TPSNR_HUMAN, Q9BX59
    Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (TAPBPL)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (TAPBPL)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018009

                  Applied Biosystems Silencer® siRNAs for TAPBPL

                  Sigma-Aldrich siRNA for TAPBPL  
                         Sigma-Aldrich shRNA for TAPBPL  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for TAPBPL
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_018009
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_018009
                                     untagged cDNA clone in CMV expression vector: NM_018009 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_018009

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    2 Interacting proteins for TAPBPL (ENSP000002665563) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VAMP1ENSP000003551223STRING (score=.853)
    CD27ENSP000002665573STRING (score=.795)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for TAPBPL

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (TAPBPL)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (TAPBPL)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018009

                  Sigma-Aldrich siRNA for TAPBPL  
                         Sigma-Aldrich shRNA for TAPBPL  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_018009  

    REFSEQ mRNAs for TAPBPL gene: 

    NM_018009.4   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_018009  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_018009
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_018009
                                     untagged cDNA clone in CMV expression vector: NM_018009 

    Additional cDNA sequence: 

    AK001005.1 AK002056.2 AK098035.1 AK222956.1 AK223163.1 BC015017.2 CR594087.1 CR598232.1 
    CR604472.1 CR622967.1 

    23 DOTS entries:

    DT.92438464  DT.97862728  DT.100642876  DT.121214676  DT.100640107  DT.121214743  DT.95334218  DT.317661 
    DT.95334214  DT.121214734  DT.91656848  DT.95170259  DT.121214753  DT.40312062  DT.95334217  DT.121214669 
    DT.92017844  DT.95334167  DT.100772134  DT.91686927  DT.92438467  DT.92438468  DT.95334215 

    9 AceView cDNA sequences:

    CR594087 CR604472 CR622967 CR598232 AK001005 NM_018009 AK002056 AK098035 
    BC015017 

    highest scoring ESTs for TAPBPL:

    AK002056 BX414902 AI656132 AK222956 AK223163 AW874151 BM713720 BQ272363 BX444361 CA426664 

    Unigene Cluster for TAPBPL:

    TAP binding protein-like
    Hs.504597  [show with all ESTs]
    Unigene Representative Sequence: AK098035


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000266556  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    TAPBPL expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for TAPBPL

    1 / 2 / 3

    7 probe-sets matching TAPBPL gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    64022_at2, 3 U95-C 1 1.00 1.00 0.80 1.32 AA829355 0.60 0.75 0.68 1
    50323_g_at2, 3 U95-B 1 1.00 1.00 0.96 1.20 AI656132 0.60 1.00 0.82 1

    57559_at2, 3 U95-C 1 0.44 1.00 0.46 0.49 AA781867 0.20 1.00 0.72 1

    218747_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_018009 0.40 0.67 0.55 1

    218746_at2, 3 U133-A 1 1.00 1.00 -- -- NM_018009 0.40 0.67 0.55 1

    218747_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    218746_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  TAPBPL for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: ACATTGGTAA

    SOURCE GeneReport for Unigene cluster: Hs.504597
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for TAPBPL gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    TAPBPL1   -- TAP binding protein-like 80.19(n)
    71.6(a)
    486727  XM_543854.2  XP_543854.2 
    chimpanzee
    (Pan troglodytes)
    TAPBPL1   -- TAP binding protein-like 98.86(n)
    99.15(a)
    451781  XM_508953.2  XP_508953.2 
    cow
    (Bos taurus)
    TAPBPL1   -- TAP binding protein-like 81.01(n)
    75.65(a)
    529141  XM_607581.3  XP_607581.2 
    rat
    (Rattus norvegicus)
    Tapbpl1   -- TAP binding protein-like 78.59(n)
    72.02(a)
    297602  XM_232355.4  XP_232355.2 
    mouse
    (Mus musculus)
    Tapbpl1, 5 65
    TAP binding protein-like1, 5 77.96(n)1
    70.53(a)1
    2132331  NM_145391.11  NP_663366.11 
     BC0176135  BC0946565  (see all 6)
    About this table        Species with no ortholog for TAPBPL

    ENSEMBL Gene Tree for TAPBPL
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for TAPBPL gene
    ENSG000001124932  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/54 NCBI SNPs in TAPBPL are shown (see all 54 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 102)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 12 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs20413871,2
    A,C,F,H,O6433084(+) TGAGGC/TGCTCT 1 A/V mis113Minor allele frequency- N:0.00EU EA WA NA 1096
    rs20413851,2
    C,F,H,O6432554(+) CCTGGC/TGAAGG 1 A/V mis120Minor allele frequency- T:0.31MN EU EA WA NS NA 2064
    rs25325001,2
    A,C,F,H6433071(-) CTTGGC/TGACCC 1 T/A mis1 ese313Minor allele frequency- T:0.23EU EA WA NA 1124
    rs25325011,2
    A,C,F,H6433014(-) CTGCAC/TGTTGG 1 M/V mis1 ese314Minor allele frequency- T:0.38EU EA WA NS NA 1266
    rs10455461,2
    C,F,H6438168(-) TCCACG/ATCACC 1 M/T mis1 ese313Minor allele frequency- A:0.15MN NA EU EA WA 1242
    rs72953761,2
    C,F,H6433029(+) CTGGAG/CGGGGA 1 R/G mis18Minor allele frequency- C:0.12EU EA WA 840
    rs20413881,2
    A,C,F,H,O6433097(+) CACCCG/AACGCT 1 P/P syn18Minor allele frequency- A:0.20EU EA WA NA 622
    rs20413841,2
    A,C,F,H6432546(+) GACTGC/TTTCCT 1 C/C syn110Minor allele frequency- T:0.35NA EA EU WA NS 893
    rs22439771,2
    A,C,F,H,O6440244(+) TCCTGC/TGCACG 1 -- int18Minor allele frequency- T:0.32EA EU WA NA 2040
    rs22437501,2
    A,C,F,H,O6438048(+) TGTAAT/CCTTAT 1 -- int18Minor allele frequency- C:0.30EA EU WA NA 1286
    About this table

    HapMap Linkage Disequilibrium images for TAPBPL (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 607081

    Human Genome Epidemiology Navigator: TAPBPL (2 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/11 PubMed articles for TAPBPL gene (see all 11 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 55080 HGNC: 30683 AceView: TAPBPL Ensembl:ENSG00000139192 euGenes: HUgn55080
    ECgene: TAPBPL H-InvDB: TAPBPL
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for TAPBPL:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for TAPBPL-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for TAPBPL Antibodies for TAPBPL
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for TAPBPL Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (Tapasin Related Protein)
     Antibodies (Tapasin Related Protein)
     Search OriGene for TAPBPL
     Search Tocris compounds for TAPBPL




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for TAPBPL

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