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Aliases & Descriptions for TAPBPL
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| FLJ10143 1, 2 | | TAPASIN-R 3 | | TAPBP-R 1, 2, 3 | | TAPBPR 1, 2 | | Tapasin-like 3 |
| | | Descriptions |
|---|
| TAP binding protein related 2 | | TAP binding protein-like 2 | | TAP-binding protein-like 3 | | TAP-binding protein-related protein 3 |
|
| | Search outside databases for aliases for TAPBPL genePrevious GC identifer: GC12P006432 |
Summaries for TAPBPL(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for TAPBPL: Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3. TAPBPL is a member of the Ig superfamily that is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC.[supplied by OMIM]
|
Genomic Location for TAPBPL
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the TAPBPL gene 
Entrez Gene cytogenetic band: 12p13.31 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13.31TAPBPL Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P006434:
(about GC identifiers)
Start:
|
6,431,438 bp from pter |
End:
|
6,441,749 bp from pter |
Size:
|
10,312 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000012.10 NT_009759.15
| Proteins for TAPBPL
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: TPSNR_HUMAN, Q9BX59 (See
protein sequence)Recommended Name: Tapasin-related protein precursor Size: 468 amino acids; 50177 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein (Probable). Endoplasmic reticulum membrane; Single-pass type I membrane protein (Probable). Microsome membrane; Single-pass type I membrane protein (Probable). Note=Mainly found in endoplasmic reticulum but a minority is found on the cell surface
Secondary accessions: Q9NWB8Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_060479.3
ENSEMBL proteins: ENSP00000266556
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for TAPBPL: Assays for TAPBPL: | Protein
Domains/ Families for TAPBPL(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9BX59
ProtoNet protein and cluster: Q9BX59 2 Blocks protein families: IPB003597 Immunoglobulin C-type IPB013106 Immunoglobulin V-set
UniProtKB/Swiss-Prot: TPSNR_HUMAN, Q9BX59Similarity: Contains 1 Ig-like C1-type (immunoglobulin-like) domainSimilarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain | Gene Function for TAPBPL
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018009
Applied Biosystems Silencer® siRNAs for TAPBPL
Sigma-Aldrich siRNA for TAPBPL  Sigma-Aldrich shRNA for TAPBPL  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_018009                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_018009                                  untagged cDNA clone in CMV expression vector: NM_018009 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_018009
| Pathways & Interactions for TAPBPL
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Interacting proteins for TAPBPL (ENSP000002665563) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0019885 | antigen processing and presentation of endogenous peptide antigen via MHC class I |
IEA | -- | About this table
|
Drugs & Compounds for TAPBPL(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for TAPBPL
|
Transcripts for TAPBPL(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_018009
Sigma-Aldrich siRNA for TAPBPL  Sigma-Aldrich shRNA for TAPBPL  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_018009 REFSEQ mRNAs for TAPBPL gene: NM_018009.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_018009               OriGene GFP tagged cDNA clone in CMV expression vector: NM_018009                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_018009                                  untagged cDNA clone in CMV expression vector: NM_018009  Additional cDNA sequence: AK001005.1 AK002056.2 AK098035.1 AK222956.1 AK223163.1 BC015017.2 CR594087.1 CR598232.1 CR604472.1 CR622967.1 23 DOTS entries: DT.92438464 DT.97862728 DT.100642876 DT.121214676 DT.100640107 DT.121214743 DT.95334218 DT.317661 DT.95334214 DT.121214734 DT.91656848 DT.95170259 DT.121214753 DT.40312062 DT.95334217 DT.121214669 DT.92017844 DT.95334167 DT.100772134 DT.91686927 DT.92438467 DT.92438468 DT.95334215 9 AceView cDNA sequences:CR594087 CR604472 CR622967 CR598232 AK001005 NM_018009 AK002056 AK098035 BC015017
highest scoring ESTs for TAPBPL:AK002056 BX414902 AI656132 AK222956 AK223163 AW874151 BM713720 BQ272363 BX444361 CA426664 Unigene Cluster for TAPBPL: TAP binding protein-like Hs.504597 [show with all ESTs]Unigene Representative Sequence: AK098035
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000266556
|
Expression for TAPBPL
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| TAPBPL expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for TAPBPL
1 / 2 / 3 7 probe-sets matching TAPBPL gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ACATTGGTAA
SOURCE GeneReport for Unigene cluster: Hs.504597
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Orthologs for TAPBPL
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TAPBPL gene from 5/7 species (see all 7
)
About this table Species with no ortholog for TAPBPL
ENSEMBL Gene Tree for TAPBPL | Paralogs for TAPBPL(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for TAPBPL gene
- ENSG000001124932
|
SNPs/Variants for TAPBPL(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for TAPBPL (up to first 250kb)
|
Disorders & Mutations for TAPBPL
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 607081
Human Genome Epidemiology Navigator: TAPBPL (2 documents)
|
Medical News for TAPBPL(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for TAPBPL (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/11 PubMed articles for TAPBPL gene (see all 11
):- A human TAPBP (TAPASIN)-related gene, TAPBP-R. (PubMed id 11920573)1, 2, 3, 4 Teng M.S....Trowsdale J. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)3, 4 Zhang Z. and Henzel W.J. (2004)
- Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)3 Chapuis J....Lambert J.C. (2009)
- Further examination of the candidate genes in chromosome 12p13 locus for late-onset Alzheimer disease. (PubMed id 18340469)3 Lee J.H....Mayeux R. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)3 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149)3 Suzuki Y.... Sugano S. (1997)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)3 Maruyama K. and Sugano S. (1994)
|
Search for TAPBPL
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TAPBPL
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing TAPBPL
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TAPBPL(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for TAPBPL(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for TAPBPL:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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