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Aliases for TAPBP Gene

Aliases for TAPBP Gene

  • TAP Binding Protein (Tapasin) 2 3
  • TPSN 3 4 6
  • TAP-Associated Protein 3 4
  • TAP-Binding Protein 3 4
  • NGS-17 3 4
  • NGS17 3 4
  • TAPA 3 4
  • TPN 3 4
  • Tapasin 3

External Ids for TAPBP Gene

Summaries for TAPBP Gene

Entrez Gene Summary for TAPBP Gene

  • This gene encodes a transmembrane glycoprotein which mediates interaction between newly assembled major histocompatibility complex (MHC) class I molecules and the transporter associated with antigen processing (TAP), which is required for the transport of antigenic peptides across the endoplasmic reticulum membrane. This interaction is essential for optimal peptide loading on the MHC class I molecule. Up to four complexes of MHC class I and this protein may be bound to a single TAP molecule. This protein contains a C-terminal double-lysine motif (KKKAE) known to maintain membrane proteins in the endoplasmic reticulum. This gene lies within the major histocompatibility complex on chromosome 6. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAPBP Gene

TAPBP (TAP Binding Protein (Tapasin)) is a Protein Coding gene. Diseases associated with TAPBP include mhc class i deficiency and orbital melanoma. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include unfolded protein binding and MHC class I protein binding. An important paralog of this gene is TAPBPL.

UniProtKB/Swiss-Prot for TAPBP Gene

  • Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).

Gene Wiki entry for TAPBP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAPBP Gene

Genomics for TAPBP Gene

Genomic Location for TAPBP Gene

Start:
33,299,694 bp from pter
End:
33,314,387 bp from pter
Size:
14,694 bases
Orientation:
Minus strand

Genomic View for TAPBP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAPBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for TAPBP Gene

Proteins for TAPBP Gene

  • Protein details for TAPBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15533-TPSN_HUMAN
    Recommended name:
    Tapasin
    Protein Accession:
    O15533
    Secondary Accessions:
    • A2AB91
    • A2ABC0
    • B0V003
    • B0V0A6
    • B2ZUA4
    • E9PGM2
    • O15210
    • O15272
    • Q5STJ8
    • Q5STK6
    • Q5STQ5
    • Q5STQ6
    • Q66K65
    • Q96KK7
    • Q9HAN8
    • Q9UEE0
    • Q9UEE4
    • Q9UIZ6
    • Q9Y6K2

    Protein attributes for TAPBP Gene

    Size:
    448 amino acids
    Molecular mass:
    47626 Da
    Quaternary structure:
    • Heterodimer with PDIA3; disulfide-linked. Interacts with TAP1 and is thus a subunit of the TAP complex, also known as the peptide loading complex (PLC). Interaction with TAP1 is TAP2-independent and is required for efficient peptide-TAP interaction. Obligatory mediator for the interaction between newly assembled MHC class I molecules, calreticulin, PDIA3 and TAP. Up to 4 MHC class I/tapasin complexes bind to 1 TAP.
    SequenceCaution:
    • Sequence=AAD32924.2; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TAPBP Gene

    Alternative splice isoforms for TAPBP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAPBP Gene

Proteomics data for TAPBP Gene at MOPED

Post-translational modifications for TAPBP Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys40 and Lys104
  • Glycosylation at Asn253

Other Protein References for TAPBP Gene

No data available for DME Specific Peptides for TAPBP Gene

Domains for TAPBP Gene

Gene Families for TAPBP Gene

HGNC:
  • C1SET :Immunoglobulin superfamily / C1-set domain containing

Protein Domains for TAPBP Gene

UniProtKB/Swiss-Prot:

TPSN_HUMAN
Domain:
  • The N-terminus is required for efficient association with MHC class I molecule and for a stable interaction between MHC I and calreticulin. Binding to TAP is mediated by the C-terminal region.:
    • O15533
  • Contains 1 Ig-like C1-type (immunoglobulin-like) domain.:
    • O15533
genes like me logo Genes that share domains with TAPBP: view

Function for TAPBP Gene

Molecular function for TAPBP Gene

GENATLAS Biochemistry: tapasin,truncated actin P binding protein,21kDa,widely expressed,involved in the assembly and function of multimeric MHC class J-TAP complexes,transporter associated with antigen processing
UniProtKB/Swiss-Prot Function: Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).

Gene Ontology (GO) - Molecular Function for TAPBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12213826
GO:0015433 peptide antigen-transporting ATPase activity TAS 9238042
GO:0042288 MHC class I protein binding TAS 12788224
GO:0042605 peptide antigen binding TAS 12788224
GO:0046978 TAP1 binding TAS 12788224
genes like me logo Genes that share ontologies with TAPBP: view
genes like me logo Genes that share phenotypes with TAPBP: view

Animal Models for TAPBP Gene

MGI Knock Outs for TAPBP:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TAPBP Gene

Localization for TAPBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAPBP Gene

Endoplasmic reticulum membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAPBP Gene COMPARTMENTS Subcellular localization image for TAPBP gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
extracellular 2
plasma membrane 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TAPBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IDA 11884415
GO:0005783 endoplasmic reticulum TAS 9238042
GO:0005789 endoplasmic reticulum membrane IDA 11884415
GO:0016020 membrane --
GO:0016021 integral component of membrane TAS 9238042
genes like me logo Genes that share ontologies with TAPBP: view

Pathways for TAPBP Gene

genes like me logo Genes that share pathways with TAPBP: view

Gene Ontology (GO) - Biological Process for TAPBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002397 MHC class I protein complex assembly --
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS --
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS --
GO:0006461 protein complex assembly TAS 9271576
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER NAS 11884415
genes like me logo Genes that share ontologies with TAPBP: view

Compounds for TAPBP Gene

(9) Novoseek inferred chemical compound relationships for TAPBP Gene

Compound -log(P) Hits PubMed IDs
cysteine 19.6 3
polysaccharide 12.7 2
histidine 8.63 3
lysine 0 7
alanine 0 3
genes like me logo Genes that share compounds with TAPBP: view

Transcripts for TAPBP Gene

Unigene Clusters for TAPBP Gene

TAP binding protein (tapasin):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAPBP Gene

No ASD Table

Relevant External Links for TAPBP Gene

GeneLoc Exon Structure for
TAPBP
ECgene alternative splicing isoforms for
TAPBP

Expression for TAPBP Gene

mRNA expression in normal human tissues for TAPBP Gene

mRNA differential expression in normal tissues according to GTEx for TAPBP Gene

This gene is overexpressed in Whole Blood (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAPBP Gene

SOURCE GeneReport for Unigene cluster for TAPBP Gene Hs.370937

mRNA Expression by UniProt/SwissProt for TAPBP Gene

O15533-TPSN_HUMAN
Tissue specificity: Neutrophils, mostly in fully differentiated cells
genes like me logo Genes that share expressions with TAPBP: view

Orthologs for TAPBP Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAPBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAPBP 36
  • 99.55 (n)
  • 99.78 (a)
TAPBP 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAPBP 36
  • 83.33 (n)
  • 82.33 (a)
TAPBP 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAPBP 36
  • 81.99 (n)
  • 80.49 (a)
TAPBP 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tapbp 36
  • 78.45 (n)
  • 75.12 (a)
Tapbp 16
Tapbp 37
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAPBP 37
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tapbp 36
  • 78.6 (n)
  • 76.05 (a)
chicken
(Gallus gallus)
Aves TAPBP 36
  • 50.47 (n)
  • 38.87 (a)
TPN 37
  • 34 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tapbp 36
  • 42.36 (n)
  • 32.55 (a)
zebrafish
(Danio rerio)
Actinopterygii tapbp 36
  • 45.08 (n)
  • 33.16 (a)
tapbp 37
  • 28 (a)
OneToMany
TAPBP (1 of 2) 37
  • 26 (a)
OneToMany
Species with no ortholog for TAPBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAPBP Gene

ENSEMBL:
Gene Tree for TAPBP (if available)
TreeFam:
Gene Tree for TAPBP (if available)

Paralogs for TAPBP Gene

Paralogs for TAPBP Gene

genes like me logo Genes that share paralogs with TAPBP: view

Variants for TAPBP Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TAPBP Gene

O15533-TPSN_HUMAN
The 2 alleles of TAPBP; TAPBP*01 (Tapasin*01) (shown here) and TAPBP*02 (Tapasin*02); are in linkage disequilibria with the HLA-DRB1 locus in a Japanese population

Sequence variations from dbSNP and Humsavar for TAPBP Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1014779 -- 33,308,689(-) TGTGT(C/T)GGGCT intron-variant
rs1800837 -- 33,304,849(-) GAGGG(A/G)TAATG intron-variant
rs1800838 -- 33,304,764(-) TGGGT(A/T)CCCTA intron-variant
rs2013891 -- 33,308,095(-) TCCAC(C/T)CGCCT intron-variant
rs2071888 - 33,305,078(-) GCCTA(C/G)AGTTC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TAPBP Gene

Variant ID Type Subtype PubMed ID
nsv830634 CNV Loss 17160897
nsv830635 CNV Loss 17160897
nsv823665 CNV Gain 20364138

Relevant External Links for TAPBP Gene

HapMap Linkage Disequilibrium report
TAPBP
Human Gene Mutation Database (HGMD)
TAPBP
Locus Specific Mutation Databases (LSDB)
TAPBP

Disorders for TAPBP Gene

(1) OMIM Diseases for TAPBP Gene (601962)

(1) University of Copenhagen DISEASES for TAPBP Gene

(14) Novoseek inferred disease relationships for TAPBP Gene

Disease -log(P) Hits PubMed IDs
hla class i deficiency 76.8 3
spondylitis ankylosing 43.2 3
lung carcinoma 22.9 2
tumors 17.4 26
colorectal tumors 16 4

Relevant External Links for TAPBP

Genetic Association Database (GAD)
TAPBP
Human Genome Epidemiology (HuGE) Navigator
TAPBP
genes like me logo Genes that share disorders with TAPBP: view

No data available for UniProtKB/Swiss-Prot for TAPBP Gene

Publications for TAPBP Gene

  1. Cloning and functional characterization of a subunit of the transporter associated with antigen processing. (PMID: 9238042) Li S. … Wang P. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23
  2. A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes. (PMID: 9271576) Ortmann B. … Cresswell P. (Science 1997) 3 4 23
  3. Polymorphism of TAPASIN and its linkage disequilibria with HLA class II genes in the Japanese population. (PMID: 9802609) Furukawa H. … Juji T. (Tissue Antigens 1998) 3 4 23
  4. Granulocyte-macrophage colony-stimulating factor modulates tapasin expression in human neutrophils. (PMID: 10088603) El Ouakfaoui S. … Beaulieu A.D. (J. Leukoc. Biol. 1999) 3 4 23
  5. The N-terminal region of tapasin is required to stabilize the MHC class I loading complex. (PMID: 10382748) Bangia N. … Cresswell P. (Eur. J. Immunol. 1999) 3 4 23

Products for TAPBP Gene

Sources for TAPBP Gene

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