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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAP2 Gene

protein-coding   GIFtS: 63
GCID: GC06M032789

Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP)


(Previous symbol: ABCB3)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP)1 2     ABC182
ABCB31 2 3 5     D6S217E2
PSF22 3 5     ABC Transporter, MHC 22
RING112 3 5     Antigen Peptide Transporter 22
Peptide Supply Factor 22 3     ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 32
Peptide Transporter Involved In Antigen Processing 22 3     Transporter 2, ABC (ATP Binding Cassette)2
Peptide Transporter PSF22 3     Y13
Really Interesting New Gene 11 Protein2 3     ATP-Binding Cassette Sub-Family B Member 33
APT22 3     Peptide Transporter TAP23
PSF-22 3     

External Ids:    HGNC: 441   Entrez Gene: 68912   Ensembl: ENSG000002042677   OMIM: 1702615   UniProtKB: Q035193   

Export aliases for TAP2 gene to outside databases

Previous GC identifers: GC06M032786 GC06M032560 GC06M032837 GC06M032838 GC06M032897 GC06M032783 GC06M032531


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TAP2 Gene:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC)
transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are
divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member
of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is
located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen
presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to
the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis,
insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products
which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.
(provided by RefSeq, Jul 2008)

GeneCards Summary for TAP2 Gene: 
TAP2 (transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)) is a protein-coding gene. Diseases associated with TAP2 include mhc class i deficiency, and bare lymphocyte syndrome, type i, due to tap2 deficiency, and among its related super-pathways are ER-Phagosome pathway and Immune System. GO annotations related to this gene include transporter activity and MHC class I protein binding. An important paralog of this gene is ENSG00000250264.

UniProtKB/Swiss-Prot: TAP2_HUMAN, Q03519
Function: Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association
with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely
the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent
attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by
human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide
translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP
induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and
acts as a tapasin inhibitor, preventing MHC class I/TAP association

Gene Wiki entry for TAP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NT_113891.2  NT_167244.1  NT_167245.1  NT_167246.1  NT_167247.1  NT_167248.1  
NT_167249.1  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAP2 gene promoter:
         AML1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TAP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

TAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAP2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M032789:  view genomic region     (about GC identifiers)

Start:
32,789,610 bp from pter      End:
32,806,557 bp from pter
Size:
16,948 bases      Orientation:
minus strand

6/7 alternative locations (see all 7):
Chr6-,NT_167246 4,246,806-4,263,744      Chr6-,NT_167245 4,071,136-4,087,923      Chr6-,NT_113891.2 4,234,140-4,251,075     
Chr6-,NT_167247 4,126,506-4,143,422      Chr6-,NT_167249 4,220,533-4,237,318      Chr6-,NT_167248 4,021,717-4,038,655     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TAP2_HUMAN, Q03519 (See protein sequence)
Recommended Name: Antigen peptide transporter 2  
Size: 686 amino acids; 75664 Da
Subunit: Heterodimer of TAP1 and TAP2. Interacts with Epstein-Barr virus BLNF2a
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=The transmembrane segments
seem to form a pore in the membrane
Secondary accessions: B0V2J8 O95410 Q53FI6 Q5HY71 Q96PT8 Q9UQ83
Alternative splicing: 2 isoforms:  Q03519-1   Q03519-2   

Explore the universe of human proteins at neXtProt for TAP2: NX_Q03519

Explore proteomics data for TAP2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q03519

  • TAP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TAP2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_000535.3  NP_061313.2  

    ENSEMBL proteins: 
     ENSP00000364034   ENSP00000364032  
    Reactome Protein details: Q03519
    Human Recombinant Protein Products for TAP2: 
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    Novus Biologicals TAP2 Lysate
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TAP2 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005743NOT mitochondrial inner membrane IRD--
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005886plasma membrane IBA--

    TAP2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ABCB: ATP binding cassette transporters / subfamily B

    IUPHAR Guide to PHARMACOLOGY protein family classification: ABCB3 
    ABCB subfamily

    5/9 InterPro protein domains (see all 9):
     IPR013306 ABC_B3
     IPR003439 ABC_transporter-like
     IPR005293 Ag_transporter2
     IPR027417 P-loop_NTPase
     IPR001140 ABC_transptr_TM_dom

    Graphical View of Domain Structure for InterPro Entry Q03519

    ProtoNet protein and cluster: Q03519

    UniProtKB/Swiss-Prot: TAP2_HUMAN, Q03519
    Domain: The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2
    Similarity: Belongs to the ABC transporter superfamily. ABCB family. MHC peptide exporter (TC 3.A.1.209) subfamily
    Similarity: Contains 1 ABC transmembrane type-1 domain
    Similarity: Contains 1 ABC transporter domain


    TAP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAP2_HUMAN, Q03519
    Function: Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association
    with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely
    the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent
    attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by
    human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide
    translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP
    induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and
    acts as a tapasin inhibitor, preventing MHC class I/TAP association
    Induction: By IFNG/IFN-gamma

         Gene Ontology (GO): 5/15 molecular function terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0005215transporter activity IDA10835348
    GO:0005515protein binding IPI12213826
    GO:0005524ATP binding IDA7673167
    GO:0015197contributes to peptide transporter activity IGI7673167
         
    TAP2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TAP2:
     Increased Salmonella enterica   Synthetic lethal with Ras  Synthetic lethal with paclitax 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tap2):
     hematopoietic system  immune system 

    TAP2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TAP2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TAP2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TAP2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TAP2 

    miRNA
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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate TAP2 (see all 14):
    hsa-miR-3685 hsa-miR-148b* hsa-miR-136 hsa-miR-3607-3p hsa-miR-875-3p hsa-miR-1321 hsa-miR-589* hsa-miR-888
    SwitchGear 3'UTR luciferase reporter plasmidTAP2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAP2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TAP2 About   (see all 11)                                                                                              See pathways by source

    SuperPathContained pathways About
    1CDK-mediated phosphorylation and removal of Cdc6
    ER-Phagosome pathway0.81
    Antigen processing-Cross presentation0.81
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56
    3Immune response Antigen presentation by MHC class I
    Immune response Antigen presentation by MHC class I0.92
    4Antigen processing: Ubiquitination & Proteasome degradation
    Class I MHC mediated antigen processing & presentation0.83
    5ABC-family proteins mediated transport
    ABC transporters0.70

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TAP2
        Immune response Antigen presentation by MHC class I


    1 Cell Signaling Technology (CST) Pathway for TAP2
        Lymphocyte Signaling

    1 GeneGo (Thomson Reuters) Pathway for TAP2
        Immune response Antigen presentation by MHC class I

    5/6        Reactome Pathways for TAP2 (see all 6)
        Antigen Presentation: Folding, assembly and peptide loading of class I MHC
    Antigen processing-Cross presentation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    ER-Phagosome pathway


    5         Kegg Pathways  (Kegg details for TAP2):
        ABC transporters
    Phagosome
    Antigen processing and presentation
    Herpes simplex infection
    Primary immunodeficiency


    TAP2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TAP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/44 Interacting proteins for TAP2 (Q035191, 2, 3 ENSP000003640344) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000227816Q035181, 2, 3, ENSP000004011494EBI-780781,EBI-747259 MINT-2838330 I2D: score=5 STRING: ENSP00000401149
    ENSG00000232367Q035181, 2, 3, ENSP000004023164EBI-780781,EBI-747259 MINT-2838330 I2D: score=5 STRING: ENSP00000402316
    TAP1Q035181, 2, 3, ENSP000003462064EBI-780781,EBI-747259 MINT-2838330 I2D: score=5 STRING: ENSP00000346206
    ENSG00000206297Q035181, 2, 3EBI-780781,EBI-747259 MINT-2838330 I2D: score=5 
    ENSG00000224212Q035181, 2, 3EBI-780781,EBI-747259 MINT-2838330 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001916positive regulation of T cell mediated cytotoxicity IBA--
    GO:0002474antigen processing and presentation of peptide antigen via MHC class I TAS--
    GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS--
    GO:0002481antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent IBA--
    GO:0002485antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent IBA--

    TAP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TAP2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TAP2

    1 HMDB Compound for TAP2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    10/12 Novoseek inferred chemical compound relationships for TAP2 gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    isoleucine 15.1 2 15774487 (1), 9098429 (1)
    oligonucleotide 13.9 3 11775239 (1), 9027960 (1), 9645419 (1)
    atp 11.4 9 8428770 (1), 12217520 (1), 15897556 (1), 15900495 (1) (see all 5)
    alanine 10.4 8 7957231 (2), 10626334 (1), 8477801 (1), 9098429 (1) (see all 5)
    forskolin 5.98 5 8961279 (2), 1333053 (1), 11410589 (1)
    mitoxantrone 5.44 2 11513878 (2)
    calcium 0 2 1317848 (1), 15337366 (1)
    threonine 0 4 10626334 (1), 8477801 (1), 19721454 (1)
    cyclic amp 0 1 9802424 (1)
    acth 0 3 8961279 (1)

    Search CenterWatch for drugs/clinical trials and news about TAP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TAP2 gene (2 alternative transcripts): 
    NM_000544.3  NM_018833.2  

    Unigene Cluster for TAP2:

    Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
    Hs.502  [show with all ESTs]
    Unigene Representative Sequence: NM_000544
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374899(uc003ocb.1) ENST00000374897(uc003occ.3 uc003ocd.3)
    ENST00000464100 ENST00000485701
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Additional mRNA sequence: 

    AB073779.1 AB208953.1 AF078671.1 AF105151.1 AF152583.1 AF176984.1 AK222823.1 AK223300.1 
    AK225657.1 AK225693.1 AK292963.1 AL833658.1 BC002751.2 BT009906.1 FM246456.1 L09191.1 
    L09271.1 L10287.1 M74447.1 M84748.1 U07844.1 Z22935.1 Z22936.1 

    9 DOTS entries:

    DT.91945568  DT.100754817  DT.310617  DT.100754819  DT.95220491  DT.97799200  DT.91686680  DT.95220496 
    DT.100754818 

    24/221 AceView cDNA sequences (see all 221):

    BC002751 AU105993 M84748 CA430500 BU174105 CB267339 BX283204 BM714492 
    F01995 AW152445 AL833658 AA742183 BM564383 AW016114 CA488029 AI638705 
    BU541101 BE675375 BQ689199 BE260238 BE746187 AF078671 BT009906 AA302365 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TAP2 expression in normal human tissues (normalized intensities)      TAP2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTGTATAC
    TAP2 Expression
    About this image


    TAP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             neutrophils   
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node
     
     Liver (Hepatobiliary System)
             Mature Mesothelial Cells Hepatic Mesenchyme
     
     Oral Cavity (Gastrointestinal Tract)
             TONGUE   

    See TAP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TAP2

    SOURCE GeneReport for Unigene cluster: Hs.502
        SABiosciences Expression via Pathway-Focused PCR Arrays including TAP2: 
              Antigen Presenting Cells in human mouse rat
              Drug Transporters in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TAP2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TAP2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAP2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAP2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TAP2 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tap21 , 5 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)1, 5 79.57(n)1
    76.86(a)1
      17 (17.98 cM)5
    213551  NM_011530.31  NP_035660.31 
     342035275 
    chicken
    (Gallus gallus)
    Aves TAP21 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 59.57(n)
    51.17(a)
      427728  NM_001099357.1  NP_001092827.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    50(a)
    1 → many
    GL344036.1(46053-70159)
    African clawed frog
    (Xenopus laevis)
    Amphibia AY204554.12   -- 70.69(n)    AY204554.1 
    zebrafish
    (Danio rerio)
    Actinopterygii abcb3l11 ATP-binding cassette, sub-family B (MDR/TAP), member more 54.72(n)
    49.83(a)
      368771  NM_001006594.1  NP_001006594.1 
    worm
    (Caenorhabditis elegans)
    Secernentea haf-86
    haf-46
    (see all 5)
    Protein HAF-4
    (see all 5)
    26(a)
    26(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    IV(14694032-14699940)
    I(489984-496154)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MDL26
    MDL16
    Mitochondrial inner membrane half-type ATP-binding...
    Mitochondrial inner membrane half-type ATP-binding...
    22(a)
    22(a)
    many ↔ many
    many ↔ many
    XVI(30482-32803)
    XII(528300-530387)
    barley
    (Hordeum vulgare)
    Liliopsida Hv.72712 Transcribed sequence with moderate similarity to protein more 73.38(n)    AJ474430.1 


    ENSEMBL Gene Tree for TAP2 (if available)
    TreeFam Gene Tree for TAP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TAP2 gene
    ENSG000002502642  ABCB102  ABCB82  ABCB92  TAP12  
    15 SIMAP similar genes for TAP2 using alignment to 9 protein entries:     TAP2_HUMAN (see all proteins):
    ABCB3    TAP2-G    ABCB4    NG-TRA    ABCB9    TAP1
    ABCB1    MDR1    ABCB11    ABCB8    DKFZp434I2115    ABCB5
    ABCB10    ABCB6    ABCC10

    TAP2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: TAP2_HUMAN, Q03519
    Polymorphism: 4 common alleles are officially recognized: TAP2*01:01 (TAP2A or PSF2A or RING11A), TAP2*01:02
    (TAP2E), TAP2*01:03 (TAP2F), and TAP2*02:01 (TAP2B or PSF2B or RING11B). Other relatively common alleles have
    been identified: TAP2*01D, TAP2*01E, TAP2*01F, TAP2*01G, TAP2*01H, TAP2*02B, TAP2*02C (TAP2*02:02), TAP2*02D,
    TAP2*02E, TAP2*02F, TAP2*03A and TAP2*04A. The sequence shown is that of TAP2*01:01
    Polymorphism: The allele TAP2*Bky2 is commonly found only in the Japanese population. It may be associated with
    susceptibility to Sjoegren syndrome, an autoimmune disorder characterized by abnormal dryness of the conjunctiva,
    cornea and mouth due to exocrine glands dysfunction


    10/583 SNPs in TAP2 are shown (see all 583)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18004541,2,4
    C,F,Hnon-pathogenic132800412(-) TGCTCG/ATAAGG 12 /I /V mis150Minor allele frequency- A:0.14MN NA NS EA WA CSA EU 12308
    rs2414481,2
    C,F,A,Huntested132796685(-) AGCTCT/CAGGAG 9 /Q /* stg1 int124Minor allele frequency- C:0.31MN NS EA NA WA 2770
    rs2414471,2,4
    C,F,A,Huntested132796751(-) TGCAGA/GCAGTT 9 T A mis1 int1 ese326Minor allele frequency- G:0.31MN EA NS NA WA CSA 4278
    VAR_0149994
    ----see VAR_0149992 A S mis40--------
    rs623976851,2
    C,F--32789111(+) CAGAGA/GCACTG 3 -- ds50012Minor allele frequency- G:0.04WA NA 238
    rs598532181,2
    C,F--32789168(+) TCTCCT/CGTATT 3 -- ds50017Minor allele frequency- C:0.13WA CSA NA EA 366
    rs607724341,2
    C,F--32789197(+) TTGAAA/C/TGAGCC 3 -- ds50016WA CSA NA EA 364
    rs600662201,2
    C,F--32789280(+) ACAGGC/ATCCTC 3 -- ds50012Minor allele frequency- A:0.50WA CSA 4
    rs132109611,2
    C,F,H--32789388(+) TTTGAG/AGGTGG 3 -- ds50019Minor allele frequency- A:0.02NS EA NA 660
    rs1510272681,2
    C--32789400(+) ATAAAA/GTTATT 3 -- ds50010--------

    HapMap Linkage Disequilibrium report for TAP2 (32789610 - 32806557 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for TAP2 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2660966CNV Deletion23128226
    esv2731874CNV Deletion23290073
    esv1707688CNV Deletion17803354
    esv2731872CNV Deletion23290073
    esv33465CNV Loss17666407
    nsv522573CNV Loss19592680
    nsv462891CNV Loss19166990
    nsv830633CNV Loss17160897
    esv32583CNV Loss17666407
    nsv885712CNV Loss21882294


    Human Gene Mutation Database (HGMD): TAP2

    Locus Specific Mutation Databases (LSDB): TAP2
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TAP2
    DNA2.0 Custom Variant and Variant Library Synthesis for TAP2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 170261   
    OMIM disorders: 604571  
    UniProtKB/Swiss-Prot: TAP2_HUMAN, Q03519
  • Bare lymphocyte syndrome 1 (BLS1) [MIM:604571]: A HLA class I deficiency. Contrary to bare lymphocyte
    syndromes type 2 and type 3, which are characterized by early-onset severe combined immunodeficiency, class I
    antigen deficiencies are not accompanied by particular pathologic manifestations during the first years of life.
    Systemic infections have not been described. Chronic bacterial infections, often beginning in the first decade of
    life, are restricted to the respiratory tract. Note=The disease is caused by mutations affecting the gene
    represented in this entry

  • 20/84 diseases for TAP2 (see all 84):    About MalaCards
    mhc class i deficiency    bare lymphocyte syndrome, type i, due to tap2 deficiency    spondylitis    ankylosing spondylitis
    echinococcosis    posterior uveal melanoma    bare lymphocyte syndrome    alveolar echinococcosis
    cardiac sarcoidosis    cystic echinococcosis    celiac disease    bronchiectasis
    brucellosis    diabetes mellitus    reactive arthritis    pemphigus vulgaris
    sarcoidosis    graves' disease    allergic rhinitis    pemphigus


    TAP2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/50 Novoseek inferred disease relationships for TAP2 gene (see all 50)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bare lymphocyte syndrome 70.9 2 20083708 (1), 10074494 (1)
    diabetes mellitus insulin-dependent 49 12 8002038 (2), 8477801 (2), 7871524 (1), 9599304 (1) (see all 8)
    genetic susceptibility 43.1 3 7759306 (1), 9361175 (1), 9844767 (1)
    spondylitis ankylosing 38.3 5 8770637 (2), 1570316 (1), 19480848 (1), 11096258 (1)
    autoimmune diseases 34.9 5 18851734 (1), 8847232 (1)
    cervical carcinoma 34 11 17366619 (3), 19202550 (2), 19263211 (1), 17622526 (1) (see all 6)
    burkitt lymphoma 31.4 4 11799186 (1), 11119603 (1), 10430223 (1), 7796675 (1)
    sjogrens syndrome 30.1 2 9599304 (1), 9324024 (1)
    tumors 29.2 26 10687135 (2), 11196471 (2), 12694570 (2), 18519766 (2) (see all 17)
    melanoma 27.1 23 8851724 (5), 10079252 (2), 17999701 (2), 11241306 (2) (see all 8)

    Genetic Association Database (GAD): TAP2
    Human Genome Epidemiology (HuGE) Navigator: TAP2 (86 documents)

    Export disorders for TAP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TAP2 gene, integrated from 9 sources (see all 389) (see top 10):
    (articles sorted by number of sources associating them with TAP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genotyping TAP2 variants in North American Caucasians, Brazilians, and Africans. (PubMed id 11294565)1, 2, 4, 9 Tang J.... Kaslow R.A. (2001)
    2. Association of a new allele of the TAP2 gene, TAP2*Bky2 (Val577), with susceptibility to Sjogren's syndrome. (PubMed id 9324024)1, 2, 4, 9 Kumagai S.... Saji H. (1997)
    3. Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region. (PubMed id 1946428)1, 2, 3, 9 Bahram S.... Spies T. (1991)
    4. Polymorphisms in the TAP2 gene and their association with rheumatoid arthritis. (PubMed id 8162639)1, 2, 4, 9 Singal D.P.... D'Souza M. (1994)
    5. Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2. (PubMed id 8428770)1, 2, 9 Powis S.H....Trowsdale J. (1993)
    6. TAP1 and TAP2 polymorphisms analysis in northwestern Colombian patients with systemic lupus erythematosus. (PubMed id 12634240)1, 4, 9 Correa P.A....Anaya J.M. (2003)
    7. No association of TAP1 and TAP2 genes polymorphism with risk of cervical cancer in north Indian population. (PubMed id 19263211)1, 4, 9 Kordi Tamandani D.M....Suri V. (2009)
    8. Determination of TAP1 and TAP2 polymorphism in the Chinese Han population by real-time TaqMan polymerase chain reaction. (PubMed id 18764808)1, 4, 9 Feng M.L....Liu D.Z. (2008)
    9. Genetic control of alternative splicing in the TAP2 gene: possible implication in the genetics of type 1 diabetes. (PubMed id 17192492)1, 4, 9 Qu H.Q....Polychronakos C. (2007)
    10. TAP1 and TAP2 polymorphisms and their linkage disequilibrium with HLA-DR, -DP, and -DQ in an eastern Andalusian population. (PubMed id 16216677)1, 4, 9 Alvarado-Guerri R....Lopez-Nevot M.A. (2005)
    11. Association of TAP2 gene polymorphisms in Chinese patients with rheumatoid arthritis. (PubMed id 14749980)1, 4, 9 Yu M.C....Tsai F.J. (2004)
    12. Significance of Transporter Associated with Antigen Processing 2 (TAP2) Gene Polymorphisms in Susceptibility to Dengue Viral Infection. (PubMed id 18071882)1, 4, 9 Soundravally R. and Hoti S.L. (2007)
    13. TAP1 and TAP2 gene polymorphisms in Korean patients with allergic rhinitis. (PubMed id 17982230)1, 4, 9 Kim K.R....Tae K. (2007)
    14. Association between the TAP2 gene codon 665 polymorphism and Graves' disease. (PubMed id 16721835)1, 4, 9 Chen R.H....Tsai F.J. (2006)
    15. Polymorphisms of human TAP2 detected by denaturing gradient gel electrophoresis. (PubMed id 12507827)1, 4, 9 Penfornis A....Faustman D.L. (2003)
    16. TAP1 and TAP2 polymorphism in Spanish patients with ankylosing spondylitis. (PubMed id 11096258)1, 4, 9 Fraile A....Nieto A. (2000)
    17. Allelic variants of the human putative peptide transporter involved in antigen processing. (PubMed id 1570316)1, 2, 9 Colonna M.... Spies T. (1992)
    18. TAP1 and TAP2 polymorphisms associated with ankylosin g spondylitis in genetically homogenous Chinese Han population. (PubMed id 19480848)1, 4, 9 Feng M....Liu D. (2009)
    19. Variation in the ATP-binding cassette transporter 2 gene is a separate risk factor for systemic lupus erythematosus within the MHC. (PubMed id 19387463)1, 4, 9 Ramos P.S....Moser K.L. (2009)
    20. Single nucleotide polymorphisms in antigen processing machinery component ERAP1 significantly associate with clinical outcome in cervical carcinoma. (PubMed id 19202550)1, 4, 9 Mehta A.M....Jan Fleuren G. (2009)
    21. MHC loci affecting cervical cancer risk: distinguishing the effects of HLA-DQB1 and non-HLA genes TNF, LTA, TAP1 and TAP2. (PubMed id 18650831)1, 4, 9 Ivansson E.L....Gyllensten U.B. (2008)
    22. The role of TAP1 and TAP2 gene polymorphism in idiopathic bronchiectasis in children. (PubMed id 17245734)1, 4, 9 Dogru D....Ozguc M. (2007)
    23. Analysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosis. (PubMed id 16634865)1, 4, 9 Gomez L.M....Anaya J.M. (2006)
    24. Association of TAP1 and TAP2 gene polymorphisms with systemic sclerosis in Korean patients. (PubMed id 16112028)1, 4, 9 Song Y.W....Park M.H. (2005)
    25. Analysis of TAP1 and TAP2 polymorphism of mother-infant in Chinese patients with pre-eclampsia. (PubMed id 16191421)1, 4, 9 Zhang Z....Gong F. (2005)
    26. Transporter associated with antigen processing gene 1 codon 333 and codon 637 polymorphisms are associated with primary open-angle glaucoma. (PubMed id 15887980)1, 4, 9 Lin H.J....Fan S.S. (2004)
    27. Polymorphisms of the TAP1 and TAP2 genes in human alveolar echinococcosis. (PubMed id 12648282)1, 4, 9 Zhang S....Vuitton D.A. (2003)
    28. Analysis of TAP2 polymorphisms in Finnish individuals with type I diabetes. (PubMed id 11916171)1, 4, 9 Penfornis A....Hitman G.A. (2002)
    29. Novel splicing of the human MHC-encoded peptide transporter confers unique properties. (PubMed id 9916708)1, 2, 9 Yan G.... Faustman D. (1999)
    30. Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex. (PubMed id 1741401)1, 2, 9 Powis S.H.... Trowsdale J. (1992)
    31. Association of a specific ERAP1/ARTS1 haplotype with disease susceptibility in ankylosing spondylitis. (PubMed id 19404951)1, 4, 9 Maksymowych W.P....Rahman P. (2009)
    32. Variation in HLA class I antigen-processing genes and susceptibility to human papillomavirus type 16-associated cervical cancer. (PubMed id 18248301)1, 4, 9 Deshpande A....Nolan J.P. (2008)
    33. Distribution of HLA-A, B alleles and polymorphisms of TAP and LMP genes in Korean patients with atopic dermatitis. (PubMed id 11737038)1, 4, 9 Lee H.J....Kim J.W. (2001)
    34. Polymorphisms of TAP, LMP and HLA-DM genes in the Chinese. (PubMed id 11775239)1, 4, 9 Zhu X....Wang F. (2000)
    35. DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing. (PubMed id 1453454)1, 2, 9 Beck S....Trowsdale J. (1992)
    36. No association of TAP and LMP genetic polymorphism in human brucellosis and its complications. (PubMed id 20470844)1, 4 Bravo M.J....Caballero A. (2010)
    37. TAP1 and TAP2 gene polymorphisms in childhood cystic echinococcosis. (PubMed id 20193774)1, 4 Kiper N....OzgA1As M. (2010)
    38. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)
    39. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    40. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PubMed id 20587610)1, 4 Ucisik-Akkaya E....Tevfik Dorak M. (2010)
    41. Interleukin-9 polymorphism in infants with respirator y syncytial virus infection: an opposite effect in boys and girls. (PubMed id 20503287)1, 4 Schuurhof A....Janssen R. (2010)
    42. [Distribution of tap1 and tap2 loci allelic and genot ypic frequencies in Chinese Hans] (PubMed id 19549407)1, 4 Shen W....Feng M.L. (2009)
    43. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (2009)
    44. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. (PubMed id 19258923)1, 4 Siezen C.L....Janssen R. (2009)
    45. High-density SNP screening of the major histocompatib ility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PubMed id 19851445)1, 4 Barcellos L.F....Criswell L.A. (2009)
    46. Transporter associated with antigen processing and the chaperone tapasin: are non-classical HLA genes keys to the pathogenesis of schizophrenia? (PubMed id 19217216)1, 4 Fellerhoff B. and Wank R. (2009)
    47. Genetic variants in TAP are associated with high-grade cervical neoplasia. (PubMed id 19188174)1, 4 Einstein M.H....Burk R.D. (2009)
    48. Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci. (PubMed id 19116923)1, 4 Vignal C....Wilson A.G. (2009)
    49. Several regions in the major histocompatibility complex confer risk for anti-CCP-antibody positive rheumatoid arthritis, independent of the DRB1 locus. (PubMed id 18309376)1, 4 Lee H.S....Gregersen P.K. (2008)
    50. Polymorphisms of the TAP 1 and 2 gene may influence clinical outcome of primary dengue viral infection. (PubMed id 18433405)1, 4 Soundravally R. and Hoti S.L. (2008)
    51. Genetic variants in the HLA-G region are associated with Kawasaki disease. (PubMed id 18976687)1, 4 Kim J.J....Lee J.K. (2008)
    52. Strong associations of psoriasis with antigen processing LMP and transport genes TAP differ by gender and phenotype. (PubMed id 17581627)1, 4 Kramer U....Esser C. (2007)
    53. Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. (PubMed id 17703412)1, 4 Janssen R....Hoebee B. (2007)
    54. A TAP2 genotype associated with Alzheimer's disease in APOE4 carriers. (PubMed id 16595160)1, 4 Bullido M.J....Valdivieso F. (2007)
    55. Genetic polymorphisms of LMP/TAP gene and hepatitis B virus infection risk in the Chinese population. (PubMed id 17525827)1, 4 Xu C....Cao B. (2007)
    56. Genetic predisposition of responsiveness to therapy for chronic hepatitis C. (PubMed id 16886895)1, 4 Hwang Y....Chen D.S. (2006)
    57. Human-specific nonsense mutations identified by genome sequence comparisons. (PubMed id 16395595)1, 3 Hahn Y. and Lee B. (2006)
    58. No difference in polymorphism frequency in a Turkish population with allergic rhinitis. (PubMed id 16923719)1, 4 Yilmaz I....Ozluoglu L.N. (2006)
    59. Genetic susceptibility to type 1 diabetes in the intracellular pathway of antigen processing - a subject review and cross-study comparison. (PubMed id 17491658)1, 4 Sia C. and Weinem M. (2005)
    60. TAP 2 gene Msp-I polymorphism might be associated with calcium oxalate stone disease. (PubMed id 16215317)1, 4 Huang S.H....Chen W.C. (2005)
    61. Pemphigus vulgaris is associated with the transporter associated with antigen processing (TAP) system. (PubMed id 16690408)1, 4 Slomov E....Gazit E. (2005)
    62. Is TAP2*0102 allele involved in insulin-dependent diabetes mellitus (type 1) protection? (PubMed id 15336779)1, 4 Cesari M....Pabion M. (2004)
    63. No association of TAP2 polymorphisms in Korean patients with schizophrenia. (PubMed id 15318034)1, 4 Jun T.Y....Lew T.Y. (2004)
    64. Lack of associations between HLA class II alleles and resistance to HIV-1 infection among white, non-Hispanic homosexual men. (PubMed id 15385740)1, 4 Liu C....Detels R. (2004)
    65. Lack of a strong association between HLA class II, tumour necrosis factor and transporter associated with antigen processing gene polymorphisms and virological response to alpha-interferon treatment in patients with chronic hepatitis C. (PubMed id 15548263)1, 4 Airoldi A....Pinzello G. (2004)
    66. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    67. HLA-DRB1, TAP2/TAP1, and HLA-DPB1 haplotypes in Finnish juvenile idiopathic arthritis: more complexity within the MHC. (PubMed id 15343265)1, 4 Runstadler J.A....Seldin M.F. (2004)
    68. Association of TAP and HLA-DM genes with psoriasis in Koreans. (PubMed id 12648225)1, 4 Pyo C.W....Kim T.G. (2003)
    69. Association of the TAP2*Bky2 allele with presence of SS-A/Ro and other autoantibodies in Japanese patients with systemic lupus erythematosus. (PubMed id 12729048)1, 4 Kanagawa S....Kumagai S. (2003)
    70. Comparison of TAP2 frequencies in type 1 diabetes patients and healthy controls from three ethnic groups indicates an African origin for the TAP2 G allele. (PubMed id 12786999)1, 4 Hoarau J.J....Pabion M. (2003)
    71. Association of polymorphisms in human leukocyte antigen class I and transporter associated with antigen processing genes with resistance to human immunodeficiency virus type 1 infection. (PubMed id 12717621)1, 4 Liu C....Detels R. (2003)
    72. Association of transporter associated with antigen processing genes with Behcet's disease in Japanese. (PubMed id 12911283)1, 4 Takizawa K....Yamamoto K. (2003)
    73. Lack of association between transporter associated with antigen processing (TAP) and HLA-DM gene polymorphisms and antibody levels following measles vaccination. (PubMed id 12786997)1, 4 Dhiman N....Poland G.A. (2003)
    74. Distribution of TAP gene polymorphisms and extended MHC haplotypes in Mexican Mestizos and in Seri Indians from northwest Mexico. (PubMed id 11960305)1, 4 Balladares S....Gorodezky C. (2002)
    75. A single nucleotide polymorphism of the low molecular mass polypeptide 7 gene influences the interferon response in patients with chronic hepatitis C. (PubMed id 12225333)1, 4 Sugimoto Y....Hayashi N. (2002)
    76. Analysis of the modifying effects of TAP 1/2 genes on cystic fibrosis phenotype. (PubMed id 12026214)1, 4 Ozbas-Gerceker F....Ozguc M. (2002)
    77. Lack of association between gene polymorphism of transporters associated with antigen processing and allergic rhinitis in a Japanese population. (PubMed id 12018331)1, 4 Takeuchi K....Sakakura Y. (2002)
    78. TAP1 and TAP2 gene polymorphism in rheumatoid arthritis in a population in eastern France. (PubMed id 12047361)1, 4 Zhang S.L....Toussirot E. (2002)
    79. [Antigen transporter gene polymorphism and predisposition to Graves disease: a preliminary analysis] (PubMed id 12485523)1, 4 Cai M....Fu Z. (2002)
    80. [Involvement of TAP2 and LMP7 gene polymorphisms in HCV infection] (PubMed id 11494532)1, 4 Kuzushita N....Hayashi N. (2001)
    81. The human cytomegalovirus gene product US6 inhibits ATP binding by TAP. (PubMed id 11157746)1, 2 Hewitt E.W.... Lehner P.J. (2001)
    82. HLA haplotype analysis in Finnish patients with rheumatoid arthritis. (PubMed id 11229461)1, 4 Tuokko J....Ilonen J. (2001)
    83. Polymorphism of Immune Response Genes as a Factor for Predisposition to Development of Diseases. (PubMed id 12687213)1, 4 Konenkov V.I....Smolnikova M.V. (2001)
    84. Adenovirus E19 has two mechanisms for affecting class I MHC expression. (PubMed id 10227971)1, 2 Bennett E.M.... Brodsky F.M. (1999)
    85. New TAP2 polymorphisms in Africans. (PubMed id 9672156)1, 2 Tang J.... Kaslow R.A. (1998)
    86. The ER-luminal domain of the HCMV glycoprotein US6 inhibits peptide translocation by TAP. (PubMed id 9175839)1, 2 Ahn K.... Frueh K. (1997)
    87. Evolutionary dynamics of non-coding sequences within the class II region of the human MHC. (PubMed id 8568858)1, 2 Beck S.... Trowsdale J. (1996)
    88. Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47. (PubMed id 8670825)1, 2 Ahn K.... Tampe R. (1996)
    89. Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site. (PubMed id 8955196)1, 2 Nijenhuis M. and Hammerling G.J. (1996)
    90. Novel human TAP2*103 allele shows further polymorphism in the ATP- binding domain. (PubMed id 7792761)1, 2 Cano P. and Baxter-Lowe L.A. (1995)
    91. Homozygous human TAP peptide transporter mutation in HLA class I deficiency. (PubMed id 7517574)1, 2 de la Salle H.... Tongio M.-M. (1994)
    92. Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system. (PubMed id 1529427)1, 3 Bodmer J.G....Sasazuki T. (1992)
    93. Analysis of the structural integrity of the TAP2 gene in renal cell carcinoma. (PubMed id 12963978)1, 9 Hodson I....Seliger B. (2003)
    94. Identification of domain boundaries within the N-termini of TAP1 and TAP2 and their importance in tapasin binding and tapasin-mediated increase in peptide loading of MHC class I. (PubMed id 16174096)1, 9 Procko E....Gaudet R. (2005)
    95. Critical role for the tapasin-docking site of TAP2 in the functional integrity of the MHC class I-peptide-loading complex. (PubMed id 16210614)1, 9 Leonhardt R.M....Knittler M.R. (2005)
    96. Detection of TAP family dimerizations by an in vivo assay in mammalian cells. (PubMed id 15518576)1, 9 Leveson-Gower D.B....Ling V. (2004)
    97. Assembly, intracellular localization, and nucleotide binding properties of the human peptide transporters TAP1 and TAP2 expressed by recombinant vaccinia viruses. (PubMed id 7673167)1, 9 Russ G....Bennink J.R. (1995)
    98. HLA class I antigen and transporter associated with a ntigen processing downregulation in metastatic lesions of head and neck squamou s cell carcinoma as a marker of poor prognosis. (PubMed id 20204276)1, 9 Bandoh N....Harabuchi Y. (2010)
    99. Physical and functional interactions of the cytomegalovirus US6 glycoprotein with the transporter associated with antigen processing. (PubMed id 16356928)1, 9 Halenius A....Hengel H. (2006)
    100. Functional dissection of the transmembrane domains of the transporter associated with antigen processing (TAP). (PubMed id 14679198)1, 9 Koch J....Tampe R. (2004)
    101. Differential regulation of the expression of transporters associated with antigen processing, TAP1 and TAP2, by cytokines and lipopolysaccharide in primary human macrophages. (PubMed id 12234057)1, 9 Schiffer R....Zwadlo-Klarwasser G. (2002)
    102. Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing. (PubMed id 11532960)1, 9 Gaudet R. and Wiley D.C. (2001)
    103. Polymorphisms of TAP1 and TAP2 genes in German patients with type 1 diabetes mellitus. (PubMed id 9226129)4, 9 Rau H....Badenhoop K. (1997)
    104. Polymorphisms of the TAP1 and TAP2 transporter genes in Japanese SLE. (PubMed id 9014588)4, 9 Takeuchi F....Ito K. (1996)
    105. Expression of HLA class II-associated peptide transporter and proteasome genes in human placentas and trophoblast cell lines. (PubMed id 7835969)1, 9 Roby K.F....Hunt J.S. (1994)
    106. A novel mutation in the TAP2 gene in bare lymphocyte syndrome: association with metastatic cutaneous squamous cell carcinoma. (PubMed id 20083708)1, 9 EspaA+a A....de la Calle-MartA-n O. (2010)
    107. CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF- kappaB-mediated de novo synthesis of IRF-1. (PubMed id 18694960)1, 9 Moschonas A....Eliopoulos A.G. (2008)
    108. LMP7/TAP2 gene polymorphisms and HPV infection in esophageal carcinoma patients from a high incidence area in China. (PubMed id 15774487)4, 9 Cao B....Ke Y. (2005)
    109. Association of TAP1 downregulation in human primary melanoma lesions with lack of spontaneous regression. (PubMed id 12777979)1, 9 Dissemond J....Wagner S.N. (2003)
    110. Involvement of transporter associated with antigen processing 2 (TAP2) gene polymorphisms in hepatitis C virus infection. (PubMed id 10220507)4, 9 Kuzushita N....Hori M. (1999)
    111. [Association of TAP1/TAP2 gene polymorphism with inflammatory urogenital diseases combined with joint diseases] (PubMed id 10626334)4, 9 Sartakova M.L....Korolev M.A. (1999)
    112. Association of HLA class I antigen deficiency related to a TAP2 gene mutation with familial bronchiectasis. (PubMed id 8523185)4, 9 Donato L....Geisert J. (1995)
    113. [Polymorphism of the TAP genes Japanese healthy control and type I diabetes mellitus] (PubMed id 8157258)4, 9 Yamazaki Y....Katagiri M. (1994)
    114. Susceptibility loci associated with specific and share d subtypes of lymphoid malignancies. (PubMed id 23349640)1 Vijai J....Offit K. (2013)
    115. Proteomic investigation of the interactome of FMNL1 in hematopoietic cells unveils a role in calcium-dependent membrane plasticity. (PubMed id 23182705)1 Han Y....Krackhardt A.M. (2013)
    116. Genome-wide association and longitudinal analyses reve al genetic loci linking pubertal height growth, pubertal timing and childhood ad iposity. (PubMed id 23449627)1 Cousminer D.L....Widen E. (2013)
    117. TAP expression level in tumor cells defines the nature and processing of MHC class I peptides for recognition by tumor-specific cytoto xic T lymphocytes. (PubMed id 23302073)1 El Hage F....Mami-Chouaib F. (2013)
    118. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    119. Genome-wide association study for serum complement C3 and C4 levels in healthy Chinese subjects. (PubMed id 23028341)1 Yang X....Mo Z. (2012)
    120. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    121. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    122. Direct evidence that the N-terminal extensions of the TAP complex act as autonomous interaction scaffolds for the assembly of the MHC I peptide-loading complex. (PubMed id 22638925)1 Hulpke S....Tampe R. (2012)
    123. Snm1B interacts with PSF2. (PubMed id 23189151)1 Stringer J.R. and Counter C.M. (2012)
    124. Association of TAP1 and TAP2 polymorphisms with the ou tcome of persistent HBV infection in a northeast Han Chinese population. (PubMed id 22989262)1 Qiu B....Li D. (2012)
    125. Expression of antigen processing and presenting molecu les in brain metastasis of breast cancer. (PubMed id 22065046)1 Liu Y....Okada H. (2012)
    126. A two-stage evaluation of genetic variation in immune and inflammation genes with risk of non-Hodgkin lymphoma identifies new suscepti bility locus in 6p21.3 region. (PubMed id 22911334)1 Cerhan J.R....Slager S.L. (2012)
    127. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    128. Genetic polymorphisms in MHC-encoded antigen processi ng gene TAP2: a case-control study in end-stage renal disease patients of North India. (PubMed id 21440064)1 George G.P. and Mittal R.D. (2011)
    129. Association of TAP 1 and 2 gene polymorphisms with hu man immunodeficiency virus-tuberculosis co-infection. (PubMed id 21843574)1 Sunder S.R....Valluri V.L. (2011)
    130. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    131. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    132. Genome-wide association study identifies susceptibili ty loci for IgA nephropathy. (PubMed id 21399633)1 Gharavi A.G....Lifton R.P. (2011)
    133. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    134. Ubiquitin ligase substrate identification through qua ntitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (2011)
    135. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    136. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    137. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    138. Genetic association analysis of TAP1 and TAP2 polymorp hisms with aspirin exacerbated respiratory disease and its FEV1 decline. (PubMed id 21796142)1 Kim J.H....Shin H.D. (2011)
    139. Genetic variation in the LMP/TAP gene and outcomes of hepatitis B virus infection in the Chinese population. (PubMed id 20525414)1 Shi C....Yu R.B. (2010)
    140. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (2010)
    141. Single residue within the antigen translocation compl ex TAP controls the epitope repertoire by stabilizing a receptive conformation. (PubMed id 20439763)1 Baldauf C....TampAc R. (2010)
    142. Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation. (PubMed id 19201886)2 Horst D....Ressing M.E. (2009)
    143. Structural arrangement of the transmission interface in the antigen ABC transport complex TAP. (PubMed id 19297616)1 Oancea G....TampAc R. (2009)
    144. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    145. In situ analysis of the antigen-processing machinery in acute myeloid leukaemic blasts by tissue microarray. (PubMed id 19148137)1 Hoves S....Mackensen A. (2009)
    146. Maturation pathways of dendritic cells determine TAP1 and TAP2 levels and cross-presenting function. (PubMed id 19609238)1 LA^pez-Albaitero A....Ferris R.L. (2009)
    147. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    148. Restoration of the expression of transports associated with antigen processing in human malignant melanoma increases tumor-specific immunity. (PubMed id 18385764)1 Tao J....Tu Y.T. (2008)
    149. Risk alleles for multiple sclerosis identified by a genomewide study. (PubMed id 17660530)4  ....Hauser S.L. (2007)
    150. Molecular architecture of the TAP-associated MHC class I peptide-loading complex. (PubMed id 17947644)1 Rufer E....Knittler M.R. (2007)
    151. Catalytic site modifications of TAP1 and TAP2 and their functional consequences. (PubMed id 17068338)1 Perria C.L....Raghavan M. (2006)
    152. Redox regulation facilitates optimal peptide selection by MHC class I during antigen processing. (PubMed id 17055437)1 Park B....Ahn K. (2006)
    153. The first N-terminal transmembrane helix of each subunit of the antigenic peptide transporter TAP is essential for independent tapasin binding. (PubMed id 16828748)1 Koch J....Tampe R. (2006)
    154. Exploring the minimal functional unit of the transporter associated with antigen processing. (PubMed id 16061226)1 Koch J....Tampe R. (2005)
    155. Cytoplasmic domains of the transporter associated with antigen processing and P-glycoprotein interact with subunits of the proteasome. (PubMed id 15488952)1 Begley G.S....Higgins C.F. (2005)
    156. New transporter associated with antigen processing (TAP-2) polymorphisms in the Shona people of Zimbabwe. (PubMed id 12826376)1 Lajoie J....Roger M. (2003)
    157. [Expression of transporter associated with antigen processing (TAP) in childhood acute leukemia and its clinical significance] (PubMed id 14558951)1 Xie J.J....Sun J. (2003)
    158. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
    159. Identification of domains participating in the substrate specificity and subcellular localization of the multidrug resistance proteins MRP1 and MRP2. (PubMed id 12682044)1 Konno T....Wada M. (2003)
    160. Functional cysteine-less subunits of the transporter associated with antigen processing (TAP1 and TAP2) by de novo gene assembly. (PubMed id 12505156)1 Heintke S....Tampe R. (2003)
    161. Peptides induce ATP hydrolysis at both subunits of the transporter associated with antigen processing. (PubMed id 12777379)1 Chen M....Tampe R. (2003)
    162. A major role for tapasin as a stabilizer of the TAP peptide transporter and consequences for MHC class I expression. (PubMed id 12594855)1 Garbi N....Hammerling G.J. (2003)
    163. The ABC-transporter signature motif is required for peptide translocation but not peptide binding by TAP. (PubMed id 12645939)1 Hewitt E.W. and Lehner P.J. (2003)
    164. Genetic epidemiology of juvenile idiopathic arthritis. (PubMed id 12195624)4 Forre O. and Smerdel A. (2002)
    165. Interactions formed by individually expressed TAP1 and TAP2 polypeptide subunits. (PubMed id 12047747)1 Antoniou A.N....Powis S.J. (2002)
    166. Assembly and cell surface expression of TAP-independent, chloroquine-sensitive and interferon-gamma-inducible class I MHC complexes in transformed fibroblast cell lines are regulated by tapasin. (PubMed id 12202157)1 Fromm S.V....Ehrlich R. (2002)
    167. Tapasin interacts with the membrane-spanning domains of both TAP subunits and enhances the structural stability of TAP1 x TAP2 Complexes. (PubMed id 12213826)1 Raghuraman G....Raghavan M. (2002)
    168. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    169. Identification of sequences in the human peptide transporter subunit TAP1 required for transporter associated with antigen processing (TAP) function. (PubMed id 11133832)1 Ritz U....Seliger B. (2001)
    170. Distinct functions and cooperative interaction of the subunits of the transporter associated with antigen processing (TAP). (PubMed id 11381133)1 Karttunen J.T....Cresswell P. (2001)
    171. Regulation of transporters associated with antigen processing (TAPs) by nucleotide binding to, and hydrolysis by, Walker consensus sequences. (PubMed id 11774612)1 Saveanu L. and Van Endert P.M. (2001)
    172. ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation. (PubMed id 10835348)1 Shirihai O.S....Weiss M.J. (2000)
    173. Nucleotide binding by TAP mediates association with peptide and release of assembled MHC class I molecules. (PubMed id 10508608)1 Knittler M.R....Howard J.C. (1999)
    174. Association of a syndrome resembling Wegener's granulomatosis with low surface expression of HLA class-I molecules. (PubMed id 10560675)1 Moins-Teisserenc H.T....Baycal C. (1999)
    175. TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide. (PubMed id 9427624)1 Braud V.M....McMichael A.J. (1998)
    176. Reduced cell surface expression of HLA-C molecules correlates with restricted peptide binding and stable TAP interaction. (PubMed id 9551969)1 Neisig A....Neefjes J. (1998)
    177. A new human transporter associated with antigen processing alleles encodes a large C-terminal protein domain. (PubMed id 9002450)1 Cesari M.M....Pabion M. (1997)
    178. Antigen processing and presentation by human trophoblast-derived cell lines. (PubMed id 9103419)1 Gobin S.J....Van den Elsen P.J. (1997)
    179. A novel TAP 2 gene RFLP observed in a Japanese. (PubMed id 8773329)1 Pattanakitsakul S.... Ito K. (1996)
    180. Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP. (PubMed id 8805302)1 Lewis J.W....Elliott T. (1996)
    181. An epitope-selective, transporter associated with ant igen presentation (TAP)-1/2-independent pathway and a more general TAP-1/2-depe ndent antigen-processing pathway allow recognition of the HIV-1 envelope glycop rotein by CD8+ CTL. (PubMed id 7538543)1 Hammond S.A....Siliciano R.F. (1995)
    182. TAP 1 and TAP 2 transporter gene polymorphisms in multiple sclerosis: no evidence for disease association with TAP. (PubMed id 7929801)4 Vandevyver C....Raus J. (1994)
    183. Polymorphisms of the TAP2 transporter gene in systemic lupus erythematosus. (PubMed id 8311559)4 Davies E.J....Ollier W.E. (1994)
    184. Absence of association of TAP and LMP genes with type 1 (insulin-dependent) diabetes mellitus. (PubMed id 7911550)4 Kawaguchi Y....Ogihara T. (1994)
    185. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
    186. The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing. (PubMed id 8458375)1 Glynne R.... Trowsdale J. (1993)
    187. Presentation of numerous viral peptides to mouse majo r histocompatibility complex (MHC) class I-restricted T lymphocytes is mediated by the human MHC-encoded transporter or by a hybrid mouse-human transporter. (PubMed id 8496691)1 Yewdell J.W....Bennink J.R. (1993)
    188. The transporters associated with antigen presentation. (PubMed id 8453065)1 Townsend A. and Trowsdale J. (1993)
    189. Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex. (PubMed id 1538751)1 Kelly A....Townsend A. (1992)
    190. Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters. (PubMed id 2259383)1 Trowsdale J.... Kelly A. (1990)
    191. Interferon regulatory factor 7 mediates activation of Tap-2 by Epstein-Barr virus latent membrane protein 1. (PubMed id 11119603)9 Zhang L. and Pagano J.S. (2001)
    192. Linkage disequilibrium between TAP2 variants and HLA class II alleles; no primary association between TAP2 variants and insulin-dependent diabetes mellitus. (PubMed id 8477801)9 Ronningen K.S....Monos D.S. (1993)
    193. Genetic analysis of TAP2 in systemic lupus erythematosus patients from two ethnic groups. (PubMed id 8670572)9 Ocal L....Briggs D. (1996)
    194. Biogenesis of functional antigenic peptide transporter TAP requires assembly of pre-existing TAP1 with newly synthesized TAP2. (PubMed id 16624807)9 Keusekotten K....Knittler M.R. (2006)
    195. Cis elements for transporter associated with antigen-processing-2 transcription: two new promoters and an essential role of the IFN response factor binding element in IFN-gamma-mediated activation of the transcription initiator. (PubMed id 11809738)9 Guo Y....Zheng P. (2002)
    196. Family study of linkage disequilibrium between TAP2 transporter and HLA class II genes. Absence of TAP2 contribution to association with insulin-dependent diabetes mellitus. (PubMed id 8847232)9 Caillat-Zucman S....Bach J.F. (1995)
    197. Association of TAP2 polymorphism with rheumatoid arthritis is secondary to allelic association with HLA-DRB1. (PubMed id 8147927)9 Marsal S....Lanchbury J.S. (1994)
    198. A half-type ABC transporter TAPL is highly conserved between rodent and man, and the human gene is not responsive to interferon-gamma in contrast to TAP1 and TAP2. (PubMed id 11011155)9 Kobayashi A.... Maeda M. (2000)
    199. Tap-1 and Tap-2 gene therapy selectively restores conformationally dependent HLA Class I expression in type I diabetic cells. (PubMed id 7578413)9 Wang F....Faustman D.L. (1995)
    200. TAP1 and TAP2 gene polymorphisms and HLA-TAP haplotypes in Koreans based on 90 families. (PubMed id 16360840)9 Whang D.H....Park M.H. (2005)
    201. Reduced expression of TAP-1 and TAP-2 in posterior uveal melanoma is associated with progression to metastatic disease. (PubMed id 11468516)9 Cresswell A.C....Murray A.K. (2001)
    202. HLA class I antigen and transporter associated with antigen processing (TAP1 and TAP2) down-regulation in high-grade primary breast carcinoma lesions. (PubMed id 9485029)9 Vitale M....Ferrone S. (1998)
    203. TAP2 alleles in inflammatory arthritis. (PubMed id 9645419)9 Tuokko J....Ilonen J. (1998)
    204. Identification of new TAP2 alleles in gorilla: evolut ion of the locus within hominoids. (PubMed id 8662084)9 Loflin P.T....Lawlor D.A. (1996)
    205. Effects of MHC-encoded TAP1 and TAP2 gene polymorphism and matching on kidney graft rejection. (PubMed id 7645042)9 Chevrier D....Soulillou J.P. (1995)
    206. Analysis of TAP2 and HLA-DP gene polymorphism in psoriasis. (PubMed id 8002377)9 Fakler J.W....Eiermann T.H. (1994)
    207. TAP2 gene polymorphism segregates with DR-DQ in DR/DP recombinant siblings. (PubMed id 8106280)9 Eiermann T.H....Bohm B.O. (1993)
    208. Mouse strains with point mutations in TAP1 and TAP2. (PubMed id 19721454)9 Theodoratos A....Fahrer A.M. (2010)
    209. Expression of transporters associated with antigen processing and human leucocyte antigen class I in malignant melanoma and its association with prognostic factors. (PubMed id 17999701)9 Tao J....Tu Y.T. (2008)
    210. Genetic variation of antigen processing machinery components and association with cervical carcinoma. (PubMed id 17366619)9 Mehta A.M....Fleuren G.J. (2007)
    211. Functional aberrant expression of CCR2 receptor on chronically activated NK cells in patients with TAP-2 deficiency. (PubMed id 16037391)9 Hanna J....Mandelboim O. (2005)
    212. Long-range patterns of diversity and linkage disequilibrium surrounding the maize Y1 gene are indicative of an asymmetric selective sweep. (PubMed id 15161968)9 Palaisa K....Rafalski A. (2004)
    213. Lack of HLA-class I antigens in human neuroblastoma cells: analysis of its relationship to TAP and tapasin expression. (PubMed id 11260505)9 Corrias M.V....Ferrini S. (2001)
    214. TAP1 down-regulation in primary melanoma lesions: an independent marker of poor prognosis. (PubMed id 11241306)9 Kamarashev J....Dummer R. (2001)
    215. Regulation of transporter associated with antigen processing by phosphorylation. (PubMed id 10823836)9 Li Y....Yang Y. (2000)
    216. Peptide-bound major histocompatibility complex class I molecules associate with tapasin before dissociation from transporter associated with antigen processing. (PubMed id 10085102)9 Li S....Wang P. (1999)
    217. Altered kinetics of Tap-1 gene expression in macrophages following stimulation with both IFN-gamma and LPS. (PubMed id 9184698)9 Cramer L.A. and Klemsz M.J. (1997)
    218. Allelic variation in the mouse Tap-1 and Tap-2 transporter genes. (PubMed id 9164943)9 Marusina K....Monaco J.J. (1997)
    219. Polymorphisms of the TAP2 gene may influence antibody response to live measles vaccine virus. (PubMed id 9041658)9 Hayney M.S....Lipsky J.J. (1997)
    220. Y1 and Y2 receptor selective neuropeptide Y analogues: evidence for a Y1 receptor subclass. (PubMed id 7473586)9 Kirby D.A....Rivier J.E. (1995)
    221. HLA DQA1-DQB1-TAP2 haplotypes in IDDM families: no evidence for an additional contribution to disease risk by the TAP2 locus. (PubMed id 7589884)9 Esposito L....Bonifacio E. (1995)
    222. TAP2 polymorphisms in Australian multiple sclerosis patients. (PubMed id 7797612)9 Bennetts B.H....Stewart G.J. (1995)
    223. TAP2 association with insulin-dependent diabetes mellitus is secondary to HLA-DQB1. (PubMed id 7558930)9 Jackson D.G. and Capra J.D. (1995)
    224. Enhanced expression of HLA-A,B,C and inducibility of TAP-1, TAP-2, and HLA-A,B,C by interferon-gamma in a multidrug-resistant small cell lung cancer line. (PubMed id 8061113)9 Fisk B....Glisson B.S. (1994)
    225. Resistance to natural killer cell lysis conferred by TAP1/2 genes in human antigen-processing mutant cells. (PubMed id 8120379)9 Salcedo M....Ljunggren H.G. (1994)
    226. Presentation of viral antigens restricted by H-2Kb, Db or Kd in proteasome subunit LMP2- and LMP7-deficient cells. (PubMed id 8056044)9 Zhou X....Ljunggren H.G. (1994)
    227. Structural characterization of Y1 and Y2 receptors for neuropeptide Y and peptide YY by affinity cross-linking. (PubMed id 2159475)9 Sheikh S.P. and Williams J.A. (1990)
    228. Cloning and characterization of rabbit neuropeptide Y receptor subtypes. (PubMed id 19481128)9 Umeda T....Iwaasa H. (2009)
    229. Contrasting effects of selection on sequence diversity and linkage disequilibrium at two phytoene synthase loci. (PubMed id 12897253)9 Palaisa K.A....Rafalski A. (2003)
    230. Organization and functional analysis of the mouse transporter associated with antigen processing 2 promoter. (PubMed id 11238639)9 Arons E....Ehrlich R. (2001)
    231. High resolution analysis of haplotype diversity and meiotic crossover in the human TAP2 recombination hotspot. (PubMed id 10749979)9 Jeffreys A.J....Neumann R. (2000)
    232. Characterization and molecular cloning of vascular neuropeptide Y receptor subtypes in pig and dog. (PubMed id 9802394)9 Malmstrom R.E....Lundberg J.M. (1998)
    233. Analysis of allelic variation of the TAP2 gene in sarcoidosis. (PubMed id 9062964)9 Ishihara M....Inoko H. (1997)
    234. The human leukocyte antigen TAP2 gene defines the centromeric limit of melanoma susceptibility on chromosome 6p. (PubMed id 8851724)9 Lee J.E....Lawlor D.A. (1996)
    235. Linkage disequilibrium between HLA class II (DR, DQ, DP) and antigen processing (LMP, TAP, DM) genes of the major histocompatibility complex. (PubMed id 8883297)9 Djilali-Saiah I....Caillat-Zucman S. (1996)
    236. Lack of primary association between transporter associated with antigen processing genes and atopic dermatitis. (PubMed id 8543762)9 Kuwata S....Shibata Y. (1995)
    237. Molecular characterization of defective antigen processing in human prostate cancer. (PubMed id 7707419)9 Sanda M.G....Simons J.W. (1995)
    238. TAP2 gene polymorphism contributes to genetic susceptibility to multiple sclerosis. (PubMed id 7759306)9 Moins-Teisserenc H....Sabouraud O. (1995)
    239. Insulin-dependent diabetes mellitus and the major histocompatibility complex peptide transporters TAP1 and TAP2: no association in a population with a high disease incidence. (PubMed id 7871524)9 Cucca F....Powis S.H. (1994)
    240. Complete L-alanine scan of neuropeptide Y reveals ligands binding to Y1 and Y2 receptors with distinguished conformations. (PubMed id 7957231)9 Beck-Sickinger A.G....Jung G. (1994)
    241. HLA-DQ and TAP2 genes in patients with insulin-dependent diabetes mellitus. (PubMed id 8002038)9 Lotfi M....Singal D.P. (1994)
    242. Impaired antigen processing and presentation machiner y is associated with immunotolerant state in chronic hepatitis B virus infectio n. (PubMed id 20300807)9 Sukriti S....Sarin S.K. (2010)
    243. Down-regulation of HLA class I antigen-processing mac hinery components in esophageal squamous cell carcinomas: association with dise ase progression. (PubMed id 19492245)9 Liu Q....Shi J. (2009)
    244. Avian TAP genes: detection of nucleotide polymorphisms and comparative analysis across species. (PubMed id 19065762)9 Sironi L....Mariani P. (2008)
    245. Expression of major histocompatibility complex class I proteins and their antigen processing chaperones in mouse embryonic stem cells from fertilized and parthenogenetic embryos. (PubMed id 18778324)9 Lampton P.W....Warner C.M. (2008)
    246. HLA class I antigen processing machinery component expression and intratumoral T-Cell infiltrate as independent prognostic markers in ovarian carcinoma. (PubMed id 18519766)9 Han L.Y....Sood A.K. (2008)
    247. Analysis of expression of MHC class I molecules and TAP genes in malignant human cell lines. (PubMed id 17951169)9 Kaczmarek M....Kaczmarek E. (2007)
    248. The low rate of HLA class I molecules on the human embryonic stem cell line HS293 is associated with the APM components' expression level. (PubMed id 17459733)9 Cabrera C.M....Concha A. (2007)
    249. NPY and receptors in immune and inflammatory diseases. (PubMed id 17979783)9 Wheway J....Mackay F. (2007)
    250. Identification of novel fibronectin fragments detected specifically in juvenile urine. (PubMed id 17614963)9 Iida R.... Kishi K. (2007)
    251. Role of antigen-processing machinery in the in vitro resistance of squamous cell carcinoma of the head and neck cells to recognition by CTL. (PubMed id 16517708)9 LA^pez-Albaitero A....Ferris R.L. (2006)
    252. Chicken TAP genes differ from their human orthologues in locus organisation, size, sequence features and polymorphism. (PubMed id 15900495)9 Walker B.A....Kaufman J. (2005)
    253. HLA class I antigen down-regulation in primary ovary carcinoma lesions: association with disease stage. (PubMed id 15671529)9 Vitale M....Ferrone S. (2005)
    254. Identification of HLA a*0201 glioblastoma multiforme cell lines for immunotherapy by PCR-SSP and DNA sequencing. (PubMed id 15015764)9 Wu A.H....Low W.C. (2004)
    255. Mitoxantrone resistance in a small cell lung cancer cell line is associated with ABCA2 upregulation. (PubMed id 15150577)9 Boonstra R....de Vries E.G. (2004)
    256. Total loss of MHC class I in colorectal tumors can be explained by two molecular pathways: beta2-microglobulin inactivation in MSI-positive tumors and LMP7/TAP2 downregulation in MSI-negative tumors. (PubMed id 12694570)9 Cabrera C.M....Garrido F. (2003)
    257. Gene organization of human transporter associated with antigen processing-like (TAPL, ABCB9): analysis of alternative splicing variants and promoter activity. (PubMed id 13679046)9 Kobayashi A.... Maeda M. (2003)
    258. Frequencies of TAP1 and TAP2 gene polymorphisms in the Anatolian population. (PubMed id 12648275)9 Ozbas-Gerceker F. and Ozguc M. (2003)
    259. TAP1, TAP2, and HLA-DR2 alleles are predictors of cervical cancer risk. (PubMed id 12648582)9 Gostout B.S....Persing D.H. (2003)
    260. Enhanced expression of human ABC-transporter tap is associated with cellular resistance to mitoxantrone. (PubMed id 11513878)9 Lage H....Sinha P. (2001)
    261. Cloned neuropeptide Y (NPY) Y1 and pancreatic polypeptide Y4 receptors expressed in Chinese hamster ovary cells show considerable agonist-driven internalization, in contrast to the NPY Y2 receptor. (PubMed id 11179953)9 Parker S.L....Li M.D. (2001)
    262. Use of chimeric proteins to investigate the role of transporter associated with antigen processing (TAP) structural domains in peptide binding and translocation. (PubMed id 11416206)9 Arora S....Raghavan M. (2001)
    263. Molecular studies and NK cell function of a new case of TAP2 homozygous human deficiency. (PubMed id 11529920)9 Matamoros N....Lopez-Botet M. (2001)
    264. Plasticity of Y1 and Y2 receptors and neuropeptide Y fibers in patients with temporal lobe epilepsy. (PubMed id 11466452)9 Furtinger S....Sperk G. (2001)
    265. High expression of HLA-A2 on an oral squamous cell carcinoma with down-regulated transporter for antigen presentation. (PubMed id 11162627)9 Matsui M....Akatsuka T. (2001)
    266. Pairing of the nucleotide binding domains of the transporter associated with antigen processing. (PubMed id 10702242)9 Lapinski P.E....Raghavan M. (2000)
    267. Reduced recognition of metastatic melanoma cells by autologous MART-1 specific CTL: relationship to TAP expression. (PubMed id 10687135)9 Murray J.L....Ioannides C.G. (2000)
    268. Polymorphism of LMP2, TAP1, LMP7 and TAP2 in Brazilian Amerindians and Caucasoids: implications for the evolution of allelic and haplotypic diversity. (PubMed id 10651845)9 Faucz F.R....Petzl-Erler M.L. (2000)
    269. Reduced expression of MHC class I antigen in human cancer cell lines with defective LMP-7. (PubMed id 10810379)9 Yoon S.J....Heo D.S. (2000)
    270. Mechanisms of epigenetic silencing of the c21 gene in Y1 adrenocortical tumor cells. (PubMed id 11196471)9 Szyf M. and Slack A.D. (2000)
    271. Impaired CTL recognition of cells latently infected with Kaposi's sarcoma-associated herpes virus. (PubMed id 10925292)9 Brander C....Scadden D.T. (2000)
    272. Down-regulation of HLA class I antigen-processing molecules in malignant melanoma: association with disease progression. (PubMed id 10079252)9 Kageshita T....Ferrone S. (1999)
    273. Analysis of MHC encoded antigen-processing genes TAP1 and TAP2 polymorphisms in sarcoidosis. (PubMed id 10471632)9 Foley P.J....du Bois R.M. (1999)
    274. HLA class I expression and chromosomal deletions at 6 p and 15q in head and neck squamous cell carcinomas. (PubMed id 10519360)9 Feenstra M....Tilanus M. (1999)
    275. Proto-oncogene PML controls genes devoted to MHC class I antigen presentation. (PubMed id 9845074)9 Zheng P....Liu Y. (1998)
    276. Antigen processing and autoimmunity. Evaluation of mRNA abundance and function of HLA-linked genes. (PubMed id 9599304)9 Fu Y....Faustman D. (1998)
    277. Impact of the MHC-encoded HLA-DMA, DMB, and LMP2 gene polymorphisms on kidney graft outcome. (PubMed id 9757947)9 Chevrier D....Soulillou J.P. (1998)
    278. Absence of functional relevance of human transporter associated with antigen processing polymorphism for peptide selection. (PubMed id 9278325)9 Daniel S....van Endert P.M. (1997)
    279. Expression of transporter associated with antigen processing 1 and 2 (TAP1/2) in malignant melanoma cell lines. (PubMed id 9052759)9 Thor Straten P....Zeuthen J. (1997)
    280. Characterization of recombination in the HLA class II region. (PubMed id 9012413)9 Cullen M....Carrington M. (1997)
    281. Polymorphisms of TAP1 and TAP2 genes in Graves' disease. (PubMed id 9027960)9 Rau H....Badenhoop K. (1997)
    282. TAP1 and TAP2 genes in nickel allergy. (PubMed id 9303338)9 Silvennoinen-Kassinen S....Tiilikainen A. (1997)
    283. The frequency of QAP2.1 is increased in psoriasis vulgaris patients but no unusual linkage between QAP/DQA1 or QBP/DQB1. (PubMed id 9248614)9 IkAoheimo I....Tiilikainen A. (1997)
    284. Analysis of the MHC class I antigen presentation machinery in human embryonal carcinomas: evidence for deficiencies in TAP, LMP and MHC class I expression and their upregulation by IFN-gamma. (PubMed id 9420627)9 Seliger B....Schmoll H.J. (1997)
    285. Idiopathic and secondary membranous nephropathy and polymorphism at TAP1 and HLA-DMA loci. (PubMed id 9271826)9 Chevrier D....Bignon J.D. (1997)
    286. Interferon-gamma rapidly increases peptide transporter (TAP) subunit expression and peptide transport capacity in endothelial cells. (PubMed id 9195970)9 Ma W....Johnson D.R. (1997)
    287. Major histocompatibility complex class I molecules interact with both subunits of the transporter associated with antigen processing, TAP1 and TAP2. (PubMed id 9368636)9 Powis S.J. (1997)
    288. Genetic polymorphisms of the major histocompatibility complex-encoded antigen-processing genes TAP and LMP in sarcoidosis. (PubMed id 8882407)9 Ishihara M....Inoko H. (1996)
    289. Mutations to forskolin resistance result in loss of adrenocorticotropin receptors and consequent reductions in levels of G protein alpha-subunits. (PubMed id 8961279)9 Qiu R....Schimmer B.P. (1996)
    290. Cell cycle-dependent expression of TAP1, TAP2, and HLA-B27 messenger RNAs in a human breast cancer cell line. (PubMed id 8813124)9 Alpan R.S....Pardee A.B. (1996)
    291. Markedly decreased expression of TAP1 and LMP2 genes in HLA class I-deficient human tumor cell lines. (PubMed id 8803612)9 Singal D.P....Snider D.P. (1996)
    292. TAP polymorphism in patients with BehAset's disease. (PubMed id 7794046)9 GonzA!lez-Escribano M.F....SA!nchez B. (1995)
    293. Polymorphic peptide transporters in MHC class I monomorphic Syrian hamster. (PubMed id 7590974)9 Lobigs M....Mullbacher A. (1995)
    294. TAP1 and TAP2 polymorphism in HLA-B27-positive subpopulations: no allelic differences in ankylosing spondylitis and reactive arthritis. (PubMed id 8770637)9 Westman P....Koskimies S. (1995)
    295. Major histocompatibility complex-encoded antigen processing gene polymorphism in IDDM. (PubMed id 7903260)9 van Endert P.M....McDevitt H.O. (1994)
    296. Polymorphisms of transporter associated with antigen processing genes in atopic dermatitis. (PubMed id 7916022)9 Kuwata S....Shibata Y. (1994)
    297. Analysis of HLA-class-II-encoded antigen-processing genes TAP1 and TAP2 in primary biliary cirrhosis. (PubMed id 8208914)9 Gregory W.L....Bassendine M.F. (1994)
    298. TAP1 and TAP2 polymorphism in multiple sclerosis patients. (PubMed id 7928442)9 Middleton D....Savage D.A. (1994)
    299. Tap gene associations in UK caucasoids. (PubMed id 9098429)9 Donn R.P....Ollier W.E. (1994)
    300. Protection from insulin-dependent diabetes mellitus is linked to a peptide transporter gene. (PubMed id 8344340)9 Caillat-Zucman S....Bach J.F. (1993)
    301. Analysis of the MHC-encoded transporters TAP1 and TAP2 in rheumatoid arthritis: linkage with DR4 accounts for the association with a minor TAP2 allele. (PubMed id 8284790)9 Wordsworth B.P....Powis S.H. (1993)
    302. Polymorphism in the mouse Tap-1 gene. Association with abnormal CD8+ T cell development in the nonobese nondiabetic mouse. (PubMed id 8228229)9 Pearce R.B....Peterson C.M. (1993)
    303. Haplotypic variation of the transporter associated with antigen processing (TAP) genes and their extension of HLA class II region haplotypes. (PubMed id 8267790)9 Carrington M....Mann D.L. (1993)
    304. Neuropeptide Y: Y1 and Y2 affinities of the complete series of analogues with single D-residue substitutions. (PubMed id 8254609)9 Kirby D.A....Rivier J.E. (1993)
    305. Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter. (PubMed id 8342042)9 Neefjes J.J....HAommerling G.J. (1993)
    306. Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type. (PubMed id 1317848)9 Larhammar D....Wahlestedt C.R. (1992)
    307. TAP1 and TAP2 polymorphism in coeliac disease. (PubMed id 8344720)9 Powis S.H....Bell J.I. (1993)
    308. Relationship between HLA class I antigen processing m achinery component expression and the clinicopathologic characteristics of blad der carcinomas. (PubMed id 19756593)9 Cathro H.P....Frierson H.F. (2010)
    309. What is the role of alternate splicing in antigen pre sentation by major histocompatibility complex class I molecules? (PubMed id 19830395)9 Belicha-Villanueva A....Bangia N. (2010)
    310. Association of HLA class I antigen abnormalities with disease progression and early recurrence in prostate cancer. (PubMed id 19820934)9 Seliger B....Hartmann A. (2010)
    311. Differential expression of constitutive and inducible proteasome subunits in human monocyte-derived DC differentiated in the presence of IFN-alpha or IL-4. (PubMed id 19065646)9 Tosello V....Zanovello P. (2009)
    312. Neuropeptide Y induces gonadotropin-releasing hormone gene expression directly and through conditioned medium from mHypoE-38 NPY neu rons. (PubMed id 19371763)9 Dhillon S.S....Belsham D.D. (2009)
    313. Down-regulation of proteasomal subunit MB1 is an independent predictor of improved survival in ovarian cancer. (PubMed id 19243813)9 Leffers N....Nijman H.W. (2009)
    314. Histone deacetylase inhibitors induce TAP, LMP, Tapasin genes and MHC class I antigen presentation by melanoma cells. (PubMed id 18046553)9 Khan A.N....Tomasi T.B. (2008)
    315. Prioritizing genes of potential relevance to diseases affected by sex hormones: an example of myasthenia gravis. (PubMed id 18851734)9 Kaur M....Bajic V.B. (2008)
    316. Induction of MHC class I molecule cell surface expression and epigenetic activation of antigen-processing machinery components in a murine model for human papilloma virus 16-associated tumours. (PubMed id 17725605)9 Manning J....Reinis M. (2008)
    317. Association of antigen processing machinery and HLA class I defects with clinicopathological outcome in cervical carcinoma. (PubMed id 17622526)9 Mehta A.M....Fleuren G.J. (2008)
    318. Intracellular peptide transporters in human--compartmentalization of the 'peptidome'. (PubMed id 16710701)9 Herget M. and Tampe R. (2007)
    319. Characterization of the immune escape phenotype of human gastric cancers with and without high-frequency microsatellite instability. (PubMed id 17318812)9 Hirata T....Shinomura Y. (2007)
    320. NPY receptors in human cancer: a review of current knowledge. (PubMed id 17223228)9 KAPrner M. and Reubi J.C. (2007)
    321. TAP expression reduces IL-10 expressing tumor infiltrating lymphocytes and restores immunosurveillance against melanoma. (PubMed id 17278102)9 Zhang Q.J....Jefferies W.A. (2007)
    322. Upregulation of antigen-processing machinery components at mRNA level in acute lymphoblastic leukemia cells after CD40 stimulation. (PubMed id 17285277)9 Luczynski W....Krawczuk-Rybak M. (2007)
    323. Peptide YY(1-36) and peptide YY(3-36): Part I. Distribution, release and actions. (PubMed id 16687037)9 Ballantyne G.H. (2006)
    324. Peptide YY(1-36) and peptide YY(3-36): Part II. Changes after gastrointestinal surgery and bariatric surgery. (PubMed id 16756746)9 Ballantyne G.H. (2006)
    325. Neuropeptide Y-family receptors Y6 and Y7 in chicken. Cloning, pharmacological characterization, tissue distribution and conserved synteny with human chromosome region. (PubMed id 16640567)9 Bromee T....Larhammar D. (2006)
    326. Correlation between expression of major histocompatibility complex class I and that of antigen presenting machineries in carcinoma cell lines of the pancreas, biliary tract and colon. (PubMed id 16855371)9 Imanishi T....Kuroda Y. (2006)
    327. Multiple defects of the antigen-processing machinery components in human neuroblastoma: immunotherapeutic implications. (PubMed id 15897905)9 Raffaghello L....Pistoia V. (2005)
    328. Coordinated downregulation of the antigen presentation machinery and HLA class I/beta2-microglobulin complex is responsible for HLA-ABC loss in bladder cancer. (PubMed id 15455355)9 Romero J.M....Ruiz-Cabello F. (2005)
    329. Defects in the human leukocyte antigen class I antigen processing machinery in head and neck squamous cell carcinoma: association with clinical outcome. (PubMed id 15814633)9 Meissner M....Seliger B. (2005)
    330. Role of the C terminus in neuropeptide Y Y1 receptor desensitization and internalization. (PubMed id 15576634)9 Holliday N.D....Cox H.M. (2005)
    331. Immunoselective pressure and human leukocyte antigen class I antigen machinery defects in microsatellite unstable colorectal cancers. (PubMed id 16024646)9 Kloor M....von Knebel Doeberitz M. (2005)
    332. A rare transporter associated with antigen processing polymorphism overpresented in HLAlow colon cancer reveals the functional significance of the signature domain in antigen processing. (PubMed id 15897556)9 Yang T....Zheng P. (2005)
    333. Neuropeptide Y receptors in renal cell carcinomas and nephroblastomas. (PubMed id 15704095)9 Korner M....Reubi J.C. (2005)
    334. Human leukocyte antigen and antigen processing machinery component defects in astrocytic tumors. (PubMed id 16322289)9 Facoetti A....Ferrone S. (2005)
    335. The MHC-encoded class I molecule, H-2Kk, demonstrates distinct requirements of assembly factors for cell surface expression: roles of TAP, Tapasin and beta2-microglobulin. (PubMed id 15302165)9 Prasanna S.J. and Nandi D. (2004)
    336. NPY and Y receptors: lessons from transgenic and knockout models. (PubMed id 15337371)9 Lin S....Herzog H. (2004)
    337. Introduction to the reviews on neuropeptide Y. (PubMed id 15337366)9 Gehlert D.R. (2004)
    338. Neuropeptide Y: multiple receptors and multiple roles in cardiovascular diseases. (PubMed id 15503651)9 Pons J....Kitlinska J. (2004)
    339. The antigen processing machinery of class I human leukocyte antigens: linked patterns of gene expression in neoplastic cells. (PubMed id 12874016)9 Giorda E....Giacomini P. (2003)
    340. Recent developments in our understanding of the physiological role of PP-fold peptide receptor subtypes. (PubMed id 12626767)9 Berglund M.M....Gehlert D.R. (2003)
    341. [Study of HLA molecules and its associated genes expression in human ovarian cancer cells] (PubMed id 15132903)9 Ge H.L....Zhou G.Y. (2003)
    342. Clinical potentials of neuropeptide Y family of hormones. (PubMed id 11975932)9 Balasubramaniam A. (2002)
    343. RelB nuclear translocation mediated by C-terminal activator regions of Epstein-Barr virus-encoded latent membrane protein 1 and its effect on antigen-presenting function in B cells. (PubMed id 11799186)9 Pai S....Khanna R. (2002)
    344. Powering the peptide pump: TAP crosstalk with energetic nucleotides. (PubMed id 12217520)9 van Endert P.M....Lehner P. (2002)
    345. Antigen processing defects in cervical carcinomas limit the presentation of a CTL epitope from human papillomavirus 16 E6. (PubMed id 11673561)9 Evans M....Man S. (2001)
    346. Immunization with tumor-associated epitopes fused to an endoplasmic reticulum translocation signal sequence affords protection against tumors with down-regulated expression of MHC and peptide transporters. (PubMed id 11222495)9 Sherritt M....Khanna R. (2001)
    347. Histocompatibility leucocyte antigens and closely linked immunomodulatory genes in autoimmune thyroid disease. (PubMed id 11678832)9 Hunt P.J....Welsh K.I. (2001)
    348. Deficient expression of components of the MHC class I antigen processing machinery in human cervical carcinoma. (PubMed id 11713591)9 Ritz U....Seliger B. (2001)
    349. ERKs regulate cyclic AMP-induced steroid synthesis through transcription of the steroidogenic acute regulatory (StAR) gene. (PubMed id 11410589)9 Gyles S.L....Jones P.M. (2001)
    350. Posttranscriptional regulation of human leukocyte antigen G during human extravillous cytotrophoblast differentiation. (PubMed id 10819754)9 Copeman J....Cross J.C. (2000)
    351. The expression of MHC class I, TAP1/2, and LMP2/7 gene in human gastric cancer cell lines. (PubMed id 10811990)9 Kang J.K....Heo D.S. (2000)
    352. Significance of transporter associated with antigen processing gene polymorphism in living related renal transplantation. (PubMed id 10880737)9 Kobayashi T....Nakao A. (2000)
    353. HLA-DQB1*0601 is primarily associated with the susceptibility to cardiac sarcoidosis. (PubMed id 10958356)9 Naruse T.K....Inoko H. (2000)
    354. Loss of interferon-gamma inducibility of TAP1 and LMP2 in a renal cell carcinoma cell line. (PubMed id 11059775)9 Dovhey S.E....Wright K.L. (2000)
    355. Current issues in the diagnosis and treatment of SjAPgren's syndrome. (PubMed id 10503656)9 Fox R.I....Michelson P. (1999)
    356. Neuropeptide Y Y1 receptor polymorphism as a prognostic predictor in Japanese patients with IgA nephropathy. (PubMed id 10363627)9 Ito H....Hashimoto K. (1999)
    357. Splice acceptor site mutation of the transporter associated with antigen processing-1 gene in human bare lymphocyte syndrome. (PubMed id 10074494)9 Furukawa H.... Juji T. (1999)
    358. Developing immunotherapeutic strategies for the control of Epstein-Barr virus-associated malignancies. (PubMed id 10430223)9 Moss D.J....Burrows S.R. (1999)
    359. Human leukocyte antigen class II and III alleles and severity of hepatitis C virus-related chronic liver disease. (PubMed id 10094975)9 Asti M....Silini E.M. (1999)
    360. DRB1*15 and DRB1*03 extended haplotype interaction in primary Sjogren's syndrome genetic susceptibility. (PubMed id 9844767)9 Jean S....Semana G. (1998)
    361. Peptide transport in human lymphoblastoid and tumor cells: effect of transporter associated with antigen presentation (TAP) polymorphism. (PubMed id 9562372)9 Quadri S.A. and Singal D.P. (1998)
    362. NPY upregulates genes containing cyclic AMP response element in human neuroblastoma cell lines bearing Y1 and Y2 receptors: involvement of CREB. (PubMed id 9802424)9 Sheriff S....Balasubramaniam A. (1998)
    363. Neuropeptide Y and the retinal pigment epithelium: receptor subtypes, signaling, and bioelectrical responses. (PubMed id 9727410)9 Ammar D.A....Thompson D.A. (1998)
    364. Neuropeptide Y: a novel angiogenic factor from the sympathetic nerves and endothelium. (PubMed id 9686758)9 Zukowska-Grojec Z....Grant D.S. (1998)
    365. TAP gene transporter polymorphism in inflammatory bowel diseases. (PubMed id 9361175)9 Heresbach D....Semana G. (1997)
    366. Generation of novel human MHC class II mutant B-cell lines by integrating YAC DNA into a cell line homozygously deleted for the MHC class II region. (PubMed id 9259276)9 Fabb S.A....Ragoussis J. (1997)
    367. IFN-gamma gene transfer restores HLA-class I expression and MAGE-3 antigen presentation to CTL in HLA-deficient small cell lung cancer. (PubMed id 9415308)9 Traversari C....Ferrini S. (1997)

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    Entrez Gene: 6891 HGNC: 44 AceView: TAP2 Ensembl:ENSG00000204267 euGenes: HUgn6891
    ECgene: TAP2 Kegg: 6891 H-InvDB: TAP2

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    PharmGKB entry for TAP2 Pharmacogenomics, SNPs, Pathways
    TAP2basehttp://bioinf.uta.fi/TAP2base/
    ABCMdbhttp://abcmutations.hegelab.org/proteinDetails?uniprot_id=Q03519

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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