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Aliases &
Descriptions
for TAP1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| ABC17 2 | | ABCB2 2, 3, 5 | | APT1 2, 3 | | D6S114E 1, 2 | | FLJ26666 2 | | FLJ41500 2 | | OTTHUMP00000029077 2 | | PSF-1 3 | | PSF1 1, 2, 3, 5 | | RING4 1, 2, 3, 5 | | TAP1*0102N 2 | | TAP1N 2 | | Y3 3 |
| | | Descriptions |
|---|
| ABC transporter, MHC 1 2 | | ATP-binding cassette sub-family B member 2 3 | | ATP-binding cassette, sub-family B (MDR/TAP), member 2 2 | | Peptide supply factor 1 2, 3 | | Peptide transporter PSF1 3 | | Peptide transporter TAP1 3 | | Peptide transporter involved in antigen processing 1 3 | | antigen peptide transporter 1 2 | | transporter 1, ATP-binding cassette, sub-family B 2 | | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 2 | | transporter associated with antigen processing 2 | transporter, ATP-binding cassette, major histocompatibility
complex, 1 2 |
|
| |
Search outside databases for aliases for TAP1 genePrevious GC identifers: GC06U990120 GC06M032810 GC06M032583 GC06M032859 |
Summaries
for TAP1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for TAP1:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding
cassette (ABC) transporters. ABC proteins transport various molecules across extra- and
intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP,
MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the
MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is
involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the
membrane-bound compartment where class I molecules assemble. Mutations in this gene may be
associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.
[provided by RefSeq]
UniProtKB/Swiss-Prot: TAP1_HUMAN, Q03518Function: Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for
association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of
MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with
TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which
blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which
binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically
blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by
peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex
and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is
down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of
peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I moleculesGene Wiki entry for TAP1 |
Genomic Location
for TAP1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the TAP1 gene 
Entrez Gene cytogenetic band: 6p21.3 HGNC cytogenetic band: 6p21.3TAP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M032920:
(about GC identifiers)
Start:
|
32,920,964 bp from pter |
End:
|
32,929,726 bp from pter |
Size:
|
8,763 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000006.10 NT_007592.14 NT_113891.1 NT_113897.1
| Proteins
for TAP1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: TAP1_HUMAN, Q03518 (See
protein sequence)Recommended Name: Antigen peptide transporter 1 Size: 808 amino acids; 87218 Da
Subunit: Heterodimer of TAP1 and TAP2. Interacts with Epstein-Barr virus BNLF2a
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Note=The
transmembrane segments seem to form a pore in the membrane
Caution: It is uncertain whether Met-1 or Met-61 is the initiator
PDB structures from  and Proteopedia  :1JJ7 (3D)
Secondary accessions: Q16149 Q96CP4REFSEQ proteins: NP_000584.2
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
5 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for TAP1:
Assays for TAP1: | Protein
Domains/
Families
for TAP1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q03518
ProtoNet protein and cluster: Q03518 UniProtKB/Swiss-Prot: TAP1_HUMAN, Q03518Domain: The peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2Similarity: Belongs to the ABC transporter family. MHC peptide exporter (TC 3.A.1.209) subfamilySimilarity: Contains 1 ABC transmembrane type-1 domainSimilarity: Contains 1 ABC transporter domain | Gene Function
for TAP1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000593
 Applied Biosystems Silencer® siRNAs for TAP1
 Sigma-Aldrich siRNA and siRNA Panels for TAP1
Sigma-Aldrich shRNA for TAP1
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_000593
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000593
untagged cDNA clone in CMV expression vector: NM_000593
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_000593
UniProtKB/Swiss-Prot: TAP1_HUMAN, Q03518Function: Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for
association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of
MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with
TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which
blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which
binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically
blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by
peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex
and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is
down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of
peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I moleculesInduction: By interferon gamma2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Tap1):
5/11 Gene Ontology (GO) molecular function terms (links to tree view) (see all 11
): About this table | Pathways & Interactions
for TAP1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
4 Sigma-Aldrich "Your Favorite Gene" Pathways for TAP1 (Your Favorite Gene powered by Ingenuity)
Gene Network CentralTM Interacting Genes and Proteins Network for TAP1
5/11 Interacting proteins for TAP1 (Q035181, 2) via UniProtKB, MINT, and/or STRING (see all 11
)About this table
4 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds
for TAP1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for TAP1
3  Novoseek chemical compound relationships for TAP1 gene
About this table
1 PharmGKB drug compound relationship for TAP1 gene
| Drug compound |
PharmGKB Relations |
PubMed IDs for articles supporting these relationships |
| cisplatin | PD GN | 20404014 | About this table
|
Transcripts
for TAP1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000593
Sigma-Aldrich siRNA and siRNA Panels for TAP1
Sigma-Aldrich shRNA for TAP1
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_000593 REFSEQ mRNAs for TAP1 gene: NM_000593.5
Applied Biosystems TaqMan ® Gene Expression Assays: NM_000593
OriGene GFP tagged cDNA clone in CMV expression vector: NM_000593
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000593
untagged cDNA clone in CMV expression vector: NM_000593
Additional cDNA sequence: AB012644.1 AK123494.1 AK130176.1 AK302340.1 AK313762.1 AY523970.1 AY523971.2 BC014081.2 BX648013.1 CR593495.1 CR596099.1 L21204.1 L21205.1 L21206.1 L21207.1 L21208.1 S70266.1 X57521.1 X57522.1 19 DOTS entries: DT.97848033 DT.121353423 DT.100710765 DT.97861334 DT.100889868 DT.70100916 DT.98083166 DT.121353411 DT.100889871 DT.100889883 DT.92030517 DT.95261987 DT.121353477 DT.95149859 DT.97848102 DT.121353435 DT.448230 DT.92450191 DT.92450201 24/385 AceView cDNA sequences (see all 385
):AW295947 F08426 BU170375 BM555378 L21206 AX748392 AA917849 BX642395 BQ686249 BU501772 H88388 CA310298 BF513693 CA436543 BG742981 BF447100 AI274774 AA687601 BE858232 BI819555 BQ053232 BP373163 AI760172 AB012644
 highest scoring ESTs for TAP1:X57522 AA917849 AB012644 AI304693 AI346197 AL550654 AL560492 AL709381 AL710839 AW295947 Unigene Cluster for TAP1: Transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) Hs.352018 [show with all ESTs]Unigene Representative Sequence: BX648013
GeneLoc Exon Structure
|
Expression
for TAP1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| TAP1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for TAP1
1 / 2 / 3 3 probe-sets matching TAP1 gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GTGCAGGCTC
SOURCE GeneReport for Unigene cluster: Hs.352018
Expression variation in blood from EXPOLDB for TAP1 |
Orthologs
for TAP1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TAP1 gene from 5/6 species (see all 6
)
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
chimpanzee
(Pan troglodytes) |
TAP11 |
-- |
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) |
98.84(n)
98.27(a) |
471978 XM_001166911.1 XP_001166911.1 |
cow
(Bos taurus) |
TAP11 |
-- |
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) |
81.6(n)
76.34(a) |
524959 XM_603299.3 XP_603299.2 |
rat
(Rattus norvegicus) |
Tap11 |
-- |
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) |
78.58(n)
72.6(a) |
24811 NM_032055.2 NP_114444.1 |
mouse
(Mus musculus) |
Tap11, 5 |
17 (18.60 cM)5
|
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)1, 5 |
79.44(n)1
73.06(a)1 |
213541 NM_013683.11 NP_038711.11
AF0278655 AK0406295 (see all 27) |
African clawed frog
(Xenopus laevis) |
AY204551.12 |
-- |
-- |
69.22(n) |
AY204551.1 |
About this table Species with no ortholog for TAP1 | Paralogs
for TAP1(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
SNPs/Variants
for TAP1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
| UniProtKB/Swiss-Prot: TAP1_HUMAN, Q03518Polymorphism: There are five common alleles; TAP1*0101 (PSF1A), TAP1*0201 (PSF1B), TAP1*0301
(PSF1C), TAP1*0104 and TAP1*x. The sequence of TAP1*0101 is shown here
HapMap Linkage Disequilibrium images for TAP1 (up to first 250kb)
|
Disorders & Mutations
for TAP1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 170260 disorders: 604571 UniProtKB/Swiss-Prot: TAP1_HUMAN, Q03518
Defects in TAP1 are a cause of bare lymphocyte syndrome type 1 (BLS1) [MIM:604571]; also
called HLA class I deficiency. BLS1 is a class I antigen deficiency that is not accompanied by
particular pathologic manifestations during the first years of life. Systemic infections have not
been described. Chronic bacterial infections, often beginning in the first decade of life, are
restricted to the respiratory tract10/52 Novoseek disease relationships for TAP1 gene (see all 52
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hla class i deficiency |
74.37 |
1 |
10074495 (1) |
| diabetes mellitus insulin-dependent |
48.75 |
7 |
9458110 (2), 9599304 (1), 1570316 (1), 1300236 (1) (see all 6) |
| cervical carcinoma |
45.78 |
14 |
8270878 (2), 11713591 (2), 17382375 (2), 19263211 (1) (see all 9) |
| melanoma |
42.04 |
28 |
12777979 (5), 11241306 (3), 17278102 (2), 17999701 (2) (see all 11) |
| genetic susceptibility |
40.43 |
2 |
17982230 (1), 9844767 (1) |
| autoimmune diseases |
38.84 |
1 |
8635653 (1) |
| tumors |
37.66 |
49 |
9426698 (4), 11340574 (3), 8803612 (3), 17278102 (3) (see all 23) |
| allelic loss |
31.80 |
1 |
18408926 (1) |
| graves disease |
26.17 |
7 |
9027960 (2), 15711027 (2), 9599304 (1), 9730088 (1) |
| lung carcinoma |
26.00 |
5 |
9426698 (2), 8803612 (1), 16140964 (1) |
About this table
Human Gene Mutation Database: TAP1
Genetic Association Database: TAP1
Human Genome Epidemiology Navigator: TAP1 (74 documents)
|
Medical News
for TAP1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for TAP1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/334 PubMed articles for TAP1 gene (see all 334
):- Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region. (PubMed id 1946428)1, 2, 3, 4 Bahram S....Spies T. (1991)
- Novel TAP1 polymorphisms in indigenous Zimbabweans: their potential implications on TAP function and in human diseases. (PubMed id 12878362)3, 4, 6 Lajoie J.... Roger M. (2003)
- TAP1 polymorphisms in several human ethnic groups: characteristics, evolution, and genotyping strategies. (PubMed id 11250043)3, 4, 6 Tang J.... Kaslow R.A. (2001)
- TAP1 gene AccI polymorphism is associated with atopic bronchial asthma. (PubMed id 12640628)1, 3, 6 Hang L.W....Tsai F.J. (2003)
- TAP1 and TAP2 polymorphisms and their linkage disequilibrium with HLA-DR, -DP, and -DQ in an eastern Andalusian population. (PubMed id 16216677)1, 3, 6 Alvarado-Guerri R....Lopez-Nevot M.A. (2005)
- TAP1 and TAP2 polymorphisms analysis in northwestern Colombian patients with systemic lupus erythematosus. (PubMed id 12634240)1, 3, 6 Correa P.A....Anaya J.M. (2003)
- Lack of association between gene polymorphism of transporters associated with antigen processing and allergic rhinitis in a Japanese population. (PubMed id 12018331)1, 3, 6 Takeuchi K....Sakakura Y. (2002)
- The human cytomegalovirus gene product US6 inhibits ATP binding by TAP. (PubMed id 11157746)1, 3, 4 Hewitt E.W.... Lehner P.J. (2001)
- Polymorphisms of transporter associated with antigen processing type 1 (TAP1), proteasome subunit beta type 9 (PSMB9) and their common promoter in African children with different manifestations of malaria. (PubMed id 15686587)1, 3, 6 Niesporek S....May J. (2005)
- Polymorphism of transporter associated with antigen presentation 1 as a potential determinant for severity of disease in recurrent respiratory papillomatosis caused by human papillomavirus types 6 and 11. (PubMed id 14976605)1, 3, 6 Vambutas A....Steinberg B.M. (2004)
|
Search for TAP1
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TAP1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing TAP1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TAP1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for TAP1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for TAP1:
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