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TAOK3 Gene

protein-coding   GIFtS: 59
GCID: GC12M118587

TAO Kinase 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TAO Kinase 31 2     CTCL-Associated Antigen HD-CL-092 3
Cutaneous T-Cell Lymphoma-Associated Antigen HD-CL-092 3     hKFC-A2 3
Dendritic Cell-Derived Protein Kinase2 3     JNK/SAPK-Inhibitory Kinase2 3
Jun Kinase-Inhibitory Kinase2 3     EC 2.7.11.13 8
Kinase From Chicken Homolog A2 3     Serine/Threonine-Protein Kinase TAO32
Thousand And One Amino Acid Protein 32 3     STE20-Like Kinase2
DPK2 3     KDS3
JIK2 3     EC 2.7.118
MAP3K182 3     

External Ids:    HGNC: 181331   Entrez Gene: 513472   Ensembl: ENSG000001350907   UniProtKB: Q9H2K83   

Export aliases for TAOK3 gene to outside databases

Previous GC identifers: GC12M117050 GC12M115597


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TAOK3 Gene:
TAOK3 (TAO kinase 3) is a protein-coding gene. Diseases associated with TAOK3 include cutaneous t cell lymphoma, and ataxia telangiectasia. GO annotations related to this gene include protein kinase inhibitor activity and protein serine/threonine kinase activity. An important paralog of this gene is TAOK2.

UniProtKB/Swiss-Prot: TAOK3_HUMAN, Q9H2K8
Function: Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade
and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response
to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14
stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases.
Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor
(EGF)

Gene Wiki entry for TAOK3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TAOK3 gene promoter:
         Lmo2   Pax-2   AP-4   Pax-2a   Evi-1   CREB   Pax-2b   CBF-A   deltaCREB   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAOK3 promoter sequence
   Search Chromatin IP Primers for TAOK3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAOK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q   Ensembl cytogenetic band:  12q24.23   HGNC cytogenetic band: 12q

TAOK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAOK3 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M118587:  view genomic region     (about GC identifiers)

Start:
118,587,606 bp from pter      End:
118,810,750 bp from pter
Size:
223,145 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TAOK3_HUMAN, Q9H2K8 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase TAO3  
Size: 898 amino acids; 105406 Da
Subunit: Self-associates. Interacts with ERN1 and TRAF2. Interaction with TRAF2 is facilitated under ER stress
conditions, such as treatment with tunicamycin, and may promote TRAF2 phosphorylation
Sequence caution: Sequence=AAN09723.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q658N1 Q8IUM4 Q9HC79 Q9NZM9 Q9UHG7

Explore the universe of human proteins at neXtProt for TAOK3: NX_Q9H2K8

Explore proteomics data for TAOK3 at MOPED

Post-translational modifications: 

  • Autophosphorylated. Phosphorylation at Ser-324 by ATM following DNA damage is required for activation of the
    p38/MAPK14 stress-activated MAPK cascade. Phosphorylated by LRRK21
  • Ubiquitination2 at Lys260, Lys855
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TAOK3 (Q9H2K8) (see all 32)
     QIKKQFQ  LQHQTEL  KAGNILL  EYKGCYL 


    See TAOK3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057365.3  
    ENSEMBL proteins: 
     ENSP00000416374   ENSP00000376317   ENSP00000441932   ENSP00000443834   ENSP00000443487  
     ENSP00000439620   ENSP00000437389   ENSP00000443465   ENSP00000438820   ENSP00000444057  
     ENSP00000440315   ENSP00000441071   ENSP00000442541   ENSP00000438766  

    TAOK3 Human Recombinant Protein Products:

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    Novus Biologicals TAOK3 Proteins
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    Sino Biological Recombinant Protein for TAOK3
    Sino Biological Cell Lysate for TAOK3
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    Cloud-Clone Corp. Proteins for TAOK3

    TAOK3 Antibody Products:

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    Abcam antibodies for TAOK3 (Q9HC79, Q9H2K8)
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    TAOK3 Assay Products:

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    Cloud-Clone Corp. ELISAs for TAOK3
    Cloud-Clone Corp. CLIAs for TAOK3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: TAO kinase 3
    TAO subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q9H2K8

    ProtoNet protein and cluster: Q9H2K8

    UniProtKB/Swiss-Prot: TAOK3_HUMAN, Q9H2K8
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 protein kinase domain


    TAOK3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAOK3_HUMAN, Q9H2K8
    Function: Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade
    and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response
    to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14
    stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases.
    Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor
    (EGF)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA10559204
    GO:0004709MAP kinase kinase kinase activity IBA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0004860protein kinase inhibitor activity TAS10559204
         
    TAOK3 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TAOK3:
     Decreased substrate adherent c  Decreased viability with TRAIL  Increased apoptosis 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TAOK3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TAOK3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TAOK3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TAOK3

    miRNA
    Products:
        
    miRTarBase miRNAs that target TAOK3:
    hsa-mir-193b-3p (MIRT041263)

    Block miRNA regulation of human, mouse, rat TAOK3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TAOK3 (see all 71):
    hsa-miR-548j hsa-miR-3607-3p hsa-miR-106a hsa-miR-519a hsa-miR-93 hsa-miR-383 hsa-miR-3613-3p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidTAOK3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TAOK3
    Predesigned siRNA for gene silencing in human, mouse, rat TAOK3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TAOK3

    Clone
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    OriGene clones in human, mouse for TAOK3 (see all 7)
    OriGene ORF clones in mouse, rat for TAOK3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TAOK3 (NM_016281)
    Sino Biological Human cDNA Clone for TAOK3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAOK3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAOK3

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TAOK3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAOK3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TAOK3_HUMAN, Q9H2K8: Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Also localized to the peripheral
    cell membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    mitochondrion4
    cytosol3
    cytoskeleton1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005739mitochondrion ----
    GO:0005886plasma membrane IEA--

    TAOK3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TAOK3 About    
    See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    2p38 MAPK signaling pathway (Pathway Interaction Database)
    p38 MAPK signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TAOK3
        p38 MAPK signaling pathway



    1 Kegg Pathway  (Kegg details for TAOK3):
        MAPK signaling pathway


    TAOK3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TAOK3
    Interactions:

        Search GeneGlobe Interaction Network for TAOK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for TAOK3 (Q9H2K81, 3 ENSP000003763174) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ERN1O754601, 3, ENSP000004014454EBI-1384100,EBI-371750 I2D: score=2 STRING: ENSP00000401445
    TRAF2Q129331, 3, ENSP000002476684EBI-1384100,EBI-355744 I2D: score=3 STRING: ENSP00000247668
    ATMQ133153, ENSP000002786164I2D: score=1 STRING: ENSP00000278616
    ATF7P175443I2D: score=1 
    MAP2K3ENSP000003450834STRING: ENSP00000345083
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IMP10924369
    GO:0000186activation of MAPKK activity IBA--
    GO:0006281DNA repair IEA--
    GO:0006468protein phosphorylation IMP11278723
    GO:0006469negative regulation of protein kinase activity TAS10559204

    TAOK3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TAOK3

    2 HMDB Compounds for TAOK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TAOK3 gene: 
    NM_016281.3  

    Unigene Cluster for TAOK3:

    TAO kinase 3
    Hs.644420  [show with all ESTs]
    Unigene Representative Sequence: NM_016281
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000419821(uc001twv.3 uc001twx.3) ENST00000392533(uc001twy.4)
    ENST00000543709 ENST00000537305(uc001tww.3) ENST00000536979 ENST00000537952
    ENST00000537569 ENST00000540561 ENST00000537822 ENST00000536584 ENST00000538601
    ENST00000535570 ENST00000541186 ENST00000541878 ENST00000542902 ENST00000542532
    ENST00000541786 ENST00000539872
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TAOK3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TAOK3 (see all 71):
    hsa-miR-548j hsa-miR-3607-3p hsa-miR-106a hsa-miR-519a hsa-miR-93 hsa-miR-383 hsa-miR-3613-3p hsa-miR-548a-5p
    SwitchGear 3'UTR luciferase reporter plasmidTAOK3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TAOK3
    Clone
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    OriGene ORF clones in mouse, rat for TAOK3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TAOK3 (NM_016281)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAOK3
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    Primer
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    OriGene qPCR primer pairs and template standards for TAOK3
    OriGene qSTAR qPCR primer pairs in human, mouse for TAOK3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TAOK3
      QuantiTect SYBR Green Assays in human, mouse, rat TAOK3
      QuantiFast Probe-based Assays in human, mouse, rat TAOK3

    Additional mRNA sequence: 

    AF135158.1 AF161373.1 AF179867.1 AF181985.1 AF263311.1 AF328731.1 AK056370.1 AK093623.1 
    AK289558.1 AL833460.1 AL833731.1 BC002756.2 BT007185.1 BX649175.1 

    19 DOTS entries:

    DT.91811326  DT.100787488  DT.92355020  DT.100787490  DT.97775755  DT.213941  DT.86839019  DT.121166691 
    DT.40241390  DT.121166710  DT.91684341  DT.91853535  DT.92434894  DT.95373839  DT.121166718  DT.121166773 
    DT.429035  DT.95373832  DT.97781441 

    Selected AceView cDNA sequences (see all 239):

    AI057643 BP377685 AA972234 BM794796 AF135158 AA480554 CA388829 CD365044 
    AU185409 AA873296 BE336708 BC002756 AI799029 BX096671 AA070171 AA780723 
    AA988475 AA505126 AW236509 BQ018678 BQ228691 BX470798 AA970724 C00131 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TAOK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAGCCTCA
    TAOK3 Expression
    About this image

    TAOK3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TAOK3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.644420

    UniProtKB/Swiss-Prot: TAOK3_HUMAN, Q9H2K8
    Tissue specificity: Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes
    (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver

        Custom PCR Arrays for TAOK3
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    QuantiFast Probe-based Assays in human, mouse, rat TAOK3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAOK3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TAOK3 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Taok31 , 5 TAO kinase 31, 5 88.53(n)1
    95.55(a)1
      5 (56.88 cM)5
    3301771  NM_001081308.21  NP_001074777.11 
     1171201295 
    chicken
    (Gallus gallus)
    Aves TAOK31 TAO kinase 3 85.37(n)
    93.99(a)
      395499  NM_001012523.1  NP_001012541.1 
    lizard
    (Anolis carolinensis)
    Reptilia TAOK36
    TAO kinase 3
    94(a)
    1 ↔ 1
    GL343338.1(662592-714972)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.189442 Transcribed sequence with weak similarity to protein more 84.82(n)    AL858593.2 
    zebrafish
    (Danio rerio)
    Actinopterygii BM026873.12   -- 78.5(n)    BM026873.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tao6
    Tao
    47(a)
    1 → many
    X(19464418-19473841)
    worm
    (Caenorhabditis elegans)
    Secernentea kin-186
    Protein KIN-18, isoform a (kin-18) mRNA, complete ...
    36(a)
    1 → many
    III(6118632-6124067) WBGene00002201


    ENSEMBL Gene Tree for TAOK3 (if available)
    TreeFam Gene Tree for TAOK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TAOK3 gene
    TAOK22  MAP4K52  NRK2  TNIK2  MAP4K22  MAP4K12  MAP4K32  MAP4K42  
    STK102  TAOK12  MINK12  SLK2  
    Selected SIMAP similar genes for TAOK3 using alignment to 13 protein entries:     TAOK3_HUMAN (see all proteins) (see all similar genes):
    TAOK1    TAOK2    DKFZp686J1430    MAP4K5    MST4    STK3
    CDK3    STK24    TNIK    STK25    PAK2    MINK1
    MYO3A    CDK7    PAK1    MAP4K1    CDK1    MAP3K2

    TAOK3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TAOK3 (see all 3810)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0412054
    A lung adenocarcinoma sample4--see VAR_0412052 P T mis40--------
    VAR_0412064
    A lung small cell carcinoma sample4--see VAR_0412062 S Y mis40--------
    rs710694341,2
    C--118475294(+) TTTTTT/-GAGAC 1 -- int11Minor allele frequency- -:0.00NA 2
    rs1850147911,2
    --118587255(+) CTTTTC/GTTTAA 1 -- ds50010--------
    rs1904053431,2
    --118587303(+) ATGCAC/TGACTG 1 -- ds50010--------
    rs781826651,2
    F--118587344(+) GTGTGC/TGCGCG 1 -- ds50012Minor allele frequency- T:0.50CSA 4
    rs110688501,2
    F--118587351(+) CGCGCG/ATGCGC 1 -- ds50012Minor allele frequency- A:0.12WA EA 238
    rs1114197841,2
    C--118587351(+) GCGCG-/CG/GT 
            
    TGCGC
    1 -- ds50011CSA 2
    rs1157858181,2
    C,F--118587501(+) GGAGCG/AACCGA 1 -- ds50011Minor allele frequency- A:0.06WA 118
    rs123005441,2
    C,F,H--118587505(+) CGACCG/AAGGCT 1 -- ds500113Minor allele frequency- A:0.05NS EA NA CSA WA 1090

    HapMap Linkage Disequilibrium report for TAOK3 (118587606 - 118810750 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TAOK3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2662690CNV Deletion23128226
    esv1533353CNV Deletion17803354
    nsv513369CNV Insertion21212237
    nsv899547CNV Gain21882294
    nsv524938CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TAOK3
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    4 diseases for TAOK3:    
    About MalaCards
    cutaneous t cell lymphoma    ataxia telangiectasia    ataxia    neuronitis


    TAOK3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TAOK3
    Human Genome Epidemiology (HuGE) Navigator: TAOK3 (1 document)

    Export disorders for TAOK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TAOK3 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with TAOK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of DPK, a novel dendritic cell-derived protein kinase activating the ERK1/ERK2 and JNK/SAPK pathways. (PubMed id 10924369)1, 2, 3, 9 Zhang W.... Cao X. (Biochem. Biophys. Res. Commun. 2000)
    2. Human JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factor. (PubMed id 10559204)1, 2, 3, 9 Tassi E.... Wong W.T. (J. Biol. Chem. 1999)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. Signal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticity. (PubMed id 20949042)1, 2 Zach S.... Gillardon F. (PLoS ONE 2010)
    5. TAO kinases mediate activation of p38 in response to DNA damage. (PubMed id 17396146)1, 2 Raman M.... Cobb M.H. (EMBO J. 2007)
    6. SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma. (PubMed id 14996095)1, 2 Hartmann T.B.... Eichmueller S. (Br. J. Dermatol. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38. (PubMed id 13679851)1, 2 Yustein J.T....Kung H.-J. (Oncogene 2003)
    9. Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2- dependent mechanism in response to the ER stress. (PubMed id 11278723)1, 2 Yoneda T....Tohyama M. (J. Biol. Chem. 2001)
    10. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 51347 HGNC: 18133 AceView: JIK Ensembl:ENSG00000135090 euGenes: HUgn51347
    ECgene: TAOK3 Kegg: 51347 H-InvDB: TAOK3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TAOK3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TAOK3 gene:
    Search GeneIP for patents involving TAOK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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