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Aliases for TAOK3 Gene

Aliases for TAOK3 Gene

  • TAO Kinase 3 2 3 5
  • Cutaneous T-Cell Lymphoma-Associated Antigen HD-CL-09 3 4
  • Dendritic Cell-Derived Protein Kinase 3 4
  • Thousand And One Amino Acid Protein 3 3 4
  • CTCL-Associated Antigen HD-CL-09 3 4
  • Kinase From Chicken Homolog A 3 4
  • Jun Kinase-Inhibitory Kinase 3 4
  • JNK/SAPK-Inhibitory Kinase 3 4
  • EC 2.7.11.1 4 63
  • MAP3K18 3 4
  • HKFC-A 3 4
  • DPK 3 4
  • JIK 3 4
  • STE20-Like Kinase 3
  • EC 2.7.11 63
  • KDS 4

External Ids for TAOK3 Gene

Previous GeneCards Identifiers for TAOK3 Gene

  • GC12M117050
  • GC12M118587
  • GC12M115597

Summaries for TAOK3 Gene

GeneCards Summary for TAOK3 Gene

TAOK3 (TAO Kinase 3) is a Protein Coding gene. Diseases associated with TAOK3 include cutaneous t cell lymphoma and kabuki syndrome 1. Among its related pathways are MAPK signaling pathway and p38 MAPK signaling pathway (Pathway Interaction Database). GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TAOK1.

UniProtKB/Swiss-Prot for TAOK3 Gene

  • Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).

Gene Wiki entry for TAOK3 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAOK3 Gene

Genomics for TAOK3 Gene

Regulatory Elements for TAOK3 Gene

Promoters for TAOK3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TAOK3 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAOK3 Gene

Chromosome:
12
Start:
118,149,801 bp from pter
End:
118,372,945 bp from pter
Size:
223,145 bases
Orientation:
Minus strand

Genomic View for TAOK3 Gene

Genes around TAOK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAOK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAOK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAOK3 Gene

Proteins for TAOK3 Gene

  • Protein details for TAOK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2K8-TAOK3_HUMAN
    Recommended name:
    Serine/threonine-protein kinase TAO3
    Protein Accession:
    Q9H2K8
    Secondary Accessions:
    • Q658N1
    • Q8IUM4
    • Q9HC79
    • Q9NZM9
    • Q9UHG7

    Protein attributes for TAOK3 Gene

    Size:
    898 amino acids
    Molecular mass:
    105406 Da
    Quaternary structure:
    • Self-associates. Interacts with ERN1 and TRAF2. Interaction with TRAF2 is facilitated under ER stress conditions, such as treatment with tunicamycin, and may promote TRAF2 phosphorylation.
    SequenceCaution:
    • Sequence=AAN09723.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for TAOK3 Gene

Proteomics data for TAOK3 Gene at MOPED

Post-translational modifications for TAOK3 Gene

  • Autophosphorylated. Phosphorylation at Ser-324 by ATM following DNA damage is required for activation of the p38/MAPK14 stress-activated MAPK cascade. Phosphorylated by LRRK2.
  • Ubiquitination at Lys 260 and Lys 855
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for TAOK3 Gene

Gene Families for TAOK3 Gene

Suggested Antigen Peptide Sequences for TAOK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H2K8

UniProtKB/Swiss-Prot:

TAOK3_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with TAOK3: view

Function for TAOK3 Gene

Molecular function for TAOK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).

Enzyme Numbers (IUBMB) for TAOK3 Gene

Gene Ontology (GO) - Molecular Function for TAOK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0005515 protein binding IPI 11278723
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with TAOK3: view
genes like me logo Genes that share phenotypes with TAOK3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TAOK3

CRISPR Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAOK3 Gene

Localization for TAOK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAOK3 Gene

Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Also localized to the peripheral cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAOK3 Gene COMPARTMENTS Subcellular localization image for TAOK3 gene
Compartment Confidence
cytosol 4
nucleus 4
plasma membrane 4
mitochondrion 3
cytoskeleton 1
extracellular 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TAOK3 Gene

Pathways & Interactions for TAOK3 Gene

genes like me logo Genes that share pathways with TAOK3: view

Pathways by source for TAOK3 Gene

1 BioSystems pathway for TAOK3 Gene
1 KEGG pathway for TAOK3 Gene

SIGNOR curated interactions for TAOK3 Gene

Activates:

Gene Ontology (GO) - Biological Process for TAOK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IBA --
GO:0006281 DNA repair IEA --
GO:0006974 cellular response to DNA damage stimulus IDA 17396146
GO:0031098 stress-activated protein kinase signaling cascade IBA --
GO:0043507 positive regulation of JUN kinase activity IMP 11278723
genes like me logo Genes that share ontologies with TAOK3: view

Drugs & Compounds for TAOK3 Gene

(1) Drugs for TAOK3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for TAOK3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with TAOK3: view

Transcripts for TAOK3 Gene

Unigene Clusters for TAOK3 Gene

TAO kinase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAOK3 Gene

No ASD Table

Relevant External Links for TAOK3 Gene

GeneLoc Exon Structure for
TAOK3
ECgene alternative splicing isoforms for
TAOK3

Expression for TAOK3 Gene

mRNA expression in normal human tissues for TAOK3 Gene

Protein differential expression in normal tissues from HIPED for TAOK3 Gene

This gene is overexpressed in Lymph node (15.2), Peripheral blood mononuclear cells (12.8), and CD8 Tcells (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAOK3 Gene



SOURCE GeneReport for Unigene cluster for TAOK3 Gene Hs.644420

mRNA Expression by UniProt/SwissProt for TAOK3 Gene

Q9H2K8-TAOK3_HUMAN
Tissue specificity: Ubiquitously expressed at a low level, and highly expressed in peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver.
genes like me logo Genes that share expression patterns with TAOK3: view

Protein tissue co-expression partners for TAOK3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TAOK3 Gene

Orthologs for TAOK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TAOK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAOK3 36
  • 100 (a)
OneToOne
TAOK3 35
  • 95.42 (n)
  • 94.1 (a)
cow
(Bos Taurus)
Mammalia TAOK3 36
  • 98 (a)
OneToOne
TAOK3 35
  • 95.51 (n)
  • 97.88 (a)
dog
(Canis familiaris)
Mammalia TAOK3 35
  • 95.88 (n)
  • 98.33 (a)
TAOK3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taok3 16
Taok3 35
  • 88.53 (n)
  • 95.55 (a)
Taok3 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAOK3 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Taok3 35
  • 87.86 (n)
  • 95.32 (a)
chicken
(Gallus gallus)
Aves TAOK3 35
  • 85.37 (n)
  • 93.99 (a)
TAOK3 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAOK3 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.18944 35
zebrafish
(Danio rerio)
Actinopterygii taok3a 36
  • 83 (a)
OneToMany
taok3b 36
  • 70 (a)
OneToMany
taok3a 35
  • 74.91 (n)
  • 84.49 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tao 36
  • 47 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea kin-18 36
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToMany
Species with no ortholog for TAOK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAOK3 Gene

ENSEMBL:
Gene Tree for TAOK3 (if available)
TreeFam:
Gene Tree for TAOK3 (if available)

Paralogs for TAOK3 Gene

Paralogs for TAOK3 Gene

genes like me logo Genes that share paralogs with TAOK3: view

Variants for TAOK3 Gene

Sequence variations from dbSNP and Humsavar for TAOK3 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs428073 - 118,244,946(+) CCTCA(C/T)TGGTG reference, missense
VAR_041205 A lung adenocarcinoma sample
VAR_041206 A lung small cell carcinoma sample
rs55857273 - 118,160,318(+) CTTTG(C/T)AAGTG reference, missense
rs2784 -- 118,311,745(+) TCATA(C/T)AGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAOK3 Gene

Variant ID Type Subtype PubMed ID
nsv524938 CNV Gain 19592680
esv1533353 CNV Deletion 17803354
nsv513369 CNV Insertion 21212237
esv2662690 CNV Deletion 23128226
nsv899547 CNV Gain 21882294

Variation tolerance for TAOK3 Gene

Residual Variation Intolerance Score: 19.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.59; 30.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAOK3 Gene

HapMap Linkage Disequilibrium report
TAOK3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAOK3 Gene

Disorders for TAOK3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TAOK3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cutaneous t cell lymphoma
  • cutaneous t-cell lymphoma
kabuki syndrome 1
  • kabuki syndrome
- elite association - COSMIC cancer census association via MalaCards
Search TAOK3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TAOK3

Genetic Association Database (GAD)
TAOK3
Human Genome Epidemiology (HuGE) Navigator
TAOK3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAOK3
genes like me logo Genes that share disorders with TAOK3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAOK3 Gene

Publications for TAOK3 Gene

  1. Cloning of DPK, a novel dendritic cell-derived protein kinase activating the ERK1/ERK2 and JNK/SAPK pathways. (PMID: 10924369) Zhang W. … Cao X. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 23 67
  2. Human JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factor. (PMID: 10559204) Tassi E. … Wong W.T. (J. Biol. Chem. 1999) 2 3 23
  3. TAOK3, a novel genome-wide association study locus associated with morphine requirement and postoperative pain in a retrospective pediatric day surgery population. (PMID: 24909733) Cook-Sather S.D. … Hakonarson H. (Pain 2014) 3
  4. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3
  5. A comprehensive resource of interacting protein regions for refining human transcription factor networks. (PMID: 20195357) Miyamoto-Sato E. … Yanagawa H. (PLoS ONE 2010) 3

Products for TAOK3 Gene

Sources for TAOK3 Gene

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