Aliases for TAOK3 Gene
- TAO Kinase 3 2 3 5
- Cutaneous T-Cell Lymphoma-Associated Antigen HD-CL-09 3 4
- Dendritic Cell-Derived Protein Kinase 3 4
- Thousand And One Amino Acid Protein 3 3 4
- CTCL-Associated Antigen HD-CL-09 3 4
- Kinase From Chicken Homolog A 3 4
- Jun Kinase-Inhibitory Kinase 3 4
- JNK/SAPK-Inhibitory Kinase 3 4
- EC 188.8.131.52 4 63
External Ids for TAOK3 Gene
Previous GeneCards Identifiers for TAOK3 Gene
GeneCards Summary for TAOK3 Gene
TAOK3 (TAO Kinase 3) is a Protein Coding gene. Diseases associated with TAOK3 include Kabuki Syndrome 1. Among its related pathways are p38 MAPK signaling pathway (Pathway Interaction Database) and MAPK signaling pathway. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TAOK1.
UniProtKB/Swiss-Prot for TAOK3 Gene
Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).