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TAOK3 Gene

protein-coding   GIFtS: 51

GC12M117050
TAO kinase 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
DKFZp666H245 2
DPK 1, 2, 3
EC 2.7.11.1 3
FLJ31808 2
JIK 1, 2, 3
KDS 3
MAP3K18 1, 2, 3
hKFC-A 3
Descriptions
CTCL tumor antigen HD-CL-09 3
Cutaneous T-cell lymphoma tumor antigen HD-CL-09 3
Dendritic cell-derived protein kinase 3
JNK/SAPK-inhibitory kinase 3
Jun kinase-inhibitory kinase 3
Kinase from chicken homolog A 3
STE20-like kinase 2
TAO kinase 3 2
Thousand and one amino acid protein 3 3
External Ids
HGNC: 181331
Entrez Gene: 513472
UniProtKB: Q9H2K83
Ensembl: ENSG000001350907
Search outside databases for aliases for TAOK3 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: TAOK3_HUMAN, Q9H2K8
Function: Inhibits the basal activity of Jun kinase. Negatively regulated by epidermal growth
factor (EGF). When overexpressed, may activate ERK1/ERK2 and JNK/SAPK

Gene Wiki entry for TAOK3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the TAOK3 gene  

Entrez Gene cytogenetic band: 12q   Ensembl cytogenetic band:  12q24.23   HGNC cytogenetic band: 12q

TAOK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M117050:     (about GC identifiers)

Start:
117,071,989 bp from pter
End:
117,295,133 bp from pter
Size:
223,145 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000012.10  NT_009775.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TAOK3_HUMAN, Q9H2K8 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase TAO3  
Size: 898 amino acids; 105406 Da
Subunit: Self-associates
Subcellular location: Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Also localized to
the peripheral cell membrane
Secondary accessions: Q658N1 Q8IUM4 Q9HC79 Q9NZM9 Q9UHG7

Post-translational modifications:

  • Autophosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_057365.3  

    ENSEMBL proteins: 
    ENSP00000376317 ENSP00000352863 


    Human Recombinant Proteins 
    Invitrogen human recombinant proteins for TAOK3
    Millipore Purified and/or Recombinant TAOK3 Protein
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (JIK)
    Human Recombinant Proteins from Abnova (TAOK3)
                  OriGene Purified Recombinant Human Protein: TAOK3 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    GO:0005886 plasma membrane IEA--
    About this table

    Antibodies for TAOK3: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for TAOK3
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (JIK), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (TAOK3)
    Novus Biologicals Antibodies for TAOK3

    Assays for TAOK3: 
    Invitrogen Assays for TAOK3
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser_thr_pkinase
     IPR017442 Se/Thr_pkinase-rel
     IPR008271 Ser_thr_pkin_AS
     IPR000719 Prot_kinase_core


       GeneDecks  TAOK3 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9H2K8

    ProtoNet protein and cluster: Q9H2K8

    UniProtKB/Swiss-Prot: TAOK3_HUMAN, Q9H2K8
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20
    subfamily
    Similarity: Contains 1 protein kinase domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (TAOK3)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (TAOK3)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016281

                  Applied Biosystems Silencer® siRNAs for TAOK3

                  Sigma-Aldrich siRNA and siRNA Panels for TAOK3  
                         Sigma-Aldrich shRNA Panels and shRNA for TAOK3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_016281
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_016281
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_016281 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_016281

    UniProtKB/Swiss-Prot: TAOK3_HUMAN, Q9H2K8
    Function: Inhibits the basal activity of Jun kinase. Negatively regulated by epidermal growth
    factor (EGF). When overexpressed, may activate ERK1/ERK2 and JNK/SAPK
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme Number (IUBMB): EC 2.7.11.1 

    5 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0004674 protein serine/threonine kinase activity IDA10559204
    GO:0004860 protein kinase inhibitor activity TAS10559204
    GO:0005524 ATP binding IC10559204
    GO:0016740 transferase activity IDA10559204
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  TAOK3  (Your Favorite Gene powered by Ingenuity) 
     Endoplasmic Reticulum Stress Pathway

       GeneDecks  TAOK3 for the pathways selected above  
    About GeneDecksing

    1 Kegg Pathway  (Kegg details for TAOK3):
     hsa04010 MAPK signaling pathway

       GeneDecks  TAOK3 for the pathways selected above  
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    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046329 negative regulation of JNK cascade IDA10559204
    GO:0046330 positive regulation of JNK cascade IMP10924369
    GO:0046777 protein amino acid autophosphorylation IDA10559204
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for TAOK3

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (TAOK3)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (TAOK3)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_016281

                  Sigma-Aldrich siRNA and siRNA Panels for TAOK3  
                         Sigma-Aldrich shRNA Panels and shRNA for TAOK3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_016281  

    REFSEQ mRNAs for TAOK3 gene: 

    NM_016281.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_016281  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_016281
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_016281
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_016281 

    Additional cDNA sequence: 

    AF135158.1 AF161373.1 AF179867.1 AF181985.1 AF263311.1 AF328731.1 AK056370.1 AK093623.1 
    AK289558.1 AL833460.1 AL833731.1 BC002756.2 BT007185.1 BX649175.1 

    20 DOTS entries:

    DT.91811326  DT.100787488  DT.92355020  DT.100787490  DT.97775755  DT.213941  DT.86839019  DT.121166691 
    DT.40241390  DT.121166710  DT.91684341  DT.91853535  DT.95373839  DT.92434894  DT.97781441  DT.121166718 
    DT.121166773  DT.429035  DT.95373832  DT.40207146 

    24/239 AceView cDNA sequences (see all 239 ):

    C00131 BX470798 AI340133 AA780723 AF135158 AI051485 CD365036 BQ018678 
    BQ719799 AF328731 AA972234 AW291685 AI799029 BE336708 AW242896 AA988475 
    AA480554 CD365021 BX096671 AL833731 CA866863 CD627738 AA970724 CB152198 

    highest scoring ESTs for TAOK3:

    AA070171 AA345393 AA469314 AA572670 AA579551 AA780723 AA836315 AA908223 AI051485 AI127845 

    Unigene Cluster for TAOK3:

    TAO kinase 3
    Hs.644420  [show with all ESTs]
    Unigene Representative Sequence: NM_016281


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000392533  ENST00000359811  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    TAOK3 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for TAOK3

    1 / 2 / 3

    7 probe-sets matching TAOK3 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    41646_at2, 3 U95-A 1 1.00 1.00 0.56 1.39 AA576724 0.60 0.75 0.68 1

    67219_at2, 3 U95-D 1 1.00 1.00 0.90 0.91 AA825637 0.40 0.67 0.55 1

    73951_at2, 3 U95-E 1 0.94 1.00 0.81 0.73 AA885355 0.60 0.75 0.68 1

    221508_at2, 3 U133-A 1 1.00 1.00 -- -- AF181985 0.60 0.75 0.68 1

    220761_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_016281 0.40 0.67 0.55 1

    221508_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    220761_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  TAOK3 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GAGAGCCTCA

    SOURCE GeneReport for Unigene cluster: Hs.644420

    UniProtKB/Swiss-Prot: TAOK3_HUMAN, Q9H2K8
    Tissue specificity: Ubiquitously expressed at a low level, and highly expressed in peripheral blood
    leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle, heart and liver

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for TAOK3 gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    TAOK31   -- TAO kinase 3 95.43(n)
    97.66(a)
    477502  XM_857645.1  XP_862738.1 
    chimpanzee
    (Pan troglodytes)
    TAOK31   -- TAO kinase 3 96.59(n)
    95.42(a)
    452292  XM_509414.2  XP_509414.2 
    cow
    (Bos taurus)
    TAOK31   -- TAO kinase 3 95.51(n)
    97.88(a)
    534620  XM_614451.3  XP_614451.3 
    rat
    (Rattus norvegicus)
    Taok31   -- TAO kinase 3 87.86(n)
    95.32(a)
    304530  NM_001024254.1  NP_001019425.1 
    mouse
    (Mus musculus)
    Taok31, 5 55
    TAO kinase 31, 5 88.53(n)1
    95.55(a)1
    3301771  NM_001081308.11  NP_001074777.11 
     AI0066985  AI8942615  (see all 16)
    About this table        Species with no ortholog for TAOK3

    ENSEMBL Gene Tree for TAOK3
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for TAOK3 gene
    TAOK22  TAOK12  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/985 NCBI SNPs in TAOK3 are shown (see all 985 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 218)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 12 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs79653501,2
    A,C,F,H117188898(+) AGCAAA/TCTTCT 1 -- ut51 ese37Minor allele frequency- T:0.09EU EA WA NA 558
    rs123005441,2
    F,H117071888(+) CGACCG/AAGGCT 1 -- ng514Minor allele frequency- A:0.03EU EA WA 420
    rs154001,2
    C117072209(+) GAAGGG/AAGATA 1 -- ut311Minor allele frequency- A:0.00MN 184
    rs4614991,2
    A,C,F,H,O117234181(+) GAGACG/ATGGTA 1 -- int17Minor allele frequency- A:0.31NA EU EA WA 562
    rs3538881,2
    A,C,F,H,O117134744(-) CTGGCC/TGGTGG 1 -- int14Minor allele frequency- T:0.39EU EA WA 418
    rs12771751,2
    A,C,F,H,O117149238(+) TTCGGA/CAAGAT 1 -- int114Minor allele frequency- N:0.00EA NA EU WA 1228
    rs4045661,2
    A,C,F,H,O117199369(-) CTGAAA/TAATAA 1 -- int116Minor allele frequency- T:0.35EU EA WA NA 1470
    rs6730781,2
    A,C,F,H,O117275824(-) CACAGT/GGGCCT 1 -- int17Minor allele frequency- G:0.08EU EA WA NA 556
    rs6963451,2
    A,C,F,H,O117109024(-) GCACAG/CTTGGA 1 -- int111Minor allele frequency- C:0.03EU EA WA NA 978
    rs3833711,2
    A,C,F,H,O117109634(-) TAAATC/GAGGAC 1 -- int112Minor allele frequency- N:0.00EA NA EU WA 1052
    About this table

    HapMap Linkage Disequilibrium images for TAOK3 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/15 PubMed articles for TAOK3 gene (see all 15 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 51347 HGNC: 18133 AceView: JIK Ensembl:ENSG00000135090 euGenes: HUgn51347
    ECgene: TAOK3 H-InvDB: TAOK3
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for TAOK3:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for TAOK3-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for TAOK3 Antibodies for TAOK3
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for TAOK3 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (JIK)
     Antibodies (JIK)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for TAOK3




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for TAOK3

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