TAOK2 Gene
protein-coding GIFtS: 61
GCID: GC16P029985
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|
TAO kinase 2
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Aliases
for TAOK2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TAO Kinase 21 2 | | Prostate-Derived Sterile 20-Like Kinase 12 3 | | PSK1 2 3 5 | | Thousand And One Amino Acid Protein Kinase 22 3 | | PSK11 2 3 5 | | PSK-12 3 | | MAP3K171 2 3 | | HKFC-C1 | | TAO21 2 5 | | EC 2.7.11.13 8 | | KIAA08811 3 5 | | PSK1-BETA2 | | TAO11 2 | | Prostate Derived STE20-Like Kinase PSK2 | | Kinase From Chicken Homolog C2 3 | | Serine/Threonine-Protein Kinase TAO22 | | Prostate-Derived STE20-Like Kinase 12 3 | | EC 2.7.118 |
Export aliases for TAOK2 gene to outside databasesPrevious GC identifers: GC16P029892 GC16P027646 |
Summaries
for TAOK2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TAOK2:
This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cellsignaling, microtubule organization and stability, and apoptosis. Alternatively spliced transcript variants encodingdifferent isoforms have been described for this gene. (provided by RefSeq, Oct 2011)
UniProtKB/Swiss-Prot: TAOK2_HUMAN, Q9UL54Function: Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptoticbodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP,activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specificactivation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in theG2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably bymediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role inapoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. Thisfunction, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, maybe linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects theirorganization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thusNF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, butnot isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellulardomains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This processleads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation
Gene Wiki entry for TAOK2
|
Genomic Views
for TAOK2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TAOK2 gene promoter:
COUP-TF1 COUP-TF p53 COUP HNF-4alpha1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TAOK2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAOK2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2TAOK2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P029985: view genomic region
(about GC identifiers)
Start:
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29,984,962 bp from pter |
End:
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30,003,582 bp from pter |
Size:
|
18,621 bases |
Orientation:
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plus strand |
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Proteins
for TAOK2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TAOK2_HUMAN, Q9UL54 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase TAO2 Size: 1235 amino acids; 138251 Da
Cofactor: Magnesium (By similarity)
Subunit: Interacts with MAP2K3 and MAP2K6 (By similarity). Self-associates. Interacts with tubulins through theC-terminal domain. Interacts with MAP3K7 and interfers with MAP3K7-binding to CHUK and thus prevents NF-kappa-Bactivation. Isoform 2 interacts with PCDH8; this complex may also include CDH2 (By similarity)
Subcellular location: Cytoplasmic vesicle membrane; Multi-pass membrane protein (Potential). Cytoplasm, cytoskeleton.Nucleus. Note=Catalytically active full-length phosphorylated isoform 1 localizes to microtubules in the cytoplasmpredominantly on microtubule cables positioned around the nucleus. A C-terminally truncated form of isoform 1 ispresent in the nucleus; isoform 2 and kinase-defective, as well as full-length isoform 1 are excluded from the nucleus
Subcellular location: Isoform 2: Cell projection, dendrite. Note=In dendrites, colocalizes with PCDH8 (By similarity)
Sequence caution: Sequence=AAQ89301.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=BAA74904.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A5PKY1 A7MCZ2 B2RN35 B7ZM88 O94957 Q6UW73 Q7LC09 Q9NSW2Alternative splicing: 4 isoforms: Q9UL54-1 Q9UL54-2 Q9UL54-3 Q9UL54-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TAOK2: NX_Q9UL54
Post-translational modifications:
Isoforms 1 and 2 are autophosphorylated1
C-terminal cleavage of isoform 1 and subsequent nuclear localization requires CASP9 activity1
Isoform 2 is phosphorylated at 'Ser-1031' by MAPK14. This phosphorylation is required PCDH8 for endocytosis (Bysimilarity). Autophosphorylated. Phosphorylated by ATM1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UL54
4/31 DME Specific Peptides for TAOK2 (Q9UL54) (see all 31)
TAOK2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001238972.1 NP_004774.1 NP_057235.2
ENSEMBL proteins: ENSP00000310094 ENSP00000440336 ENSP00000279394 ENSP00000393048
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
TAOK2 for ontologies About GeneDecksing
TAOK2 Antibody Products:
Assay Products for TAOK2: |
Protein
Domains /
Families
for TAOK2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TAOK2 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9UL54ProtoNet protein and cluster: Q9UL54 UniProtKB/Swiss-Prot: TAOK2_HUMAN, Q9UL54Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamilySimilarity: Contains 1 protein kinase domain |
Function
for TAOK2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TAOK2_HUMAN, Q9UL54Function: Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptoticbodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP,activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specificactivation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in theG2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably bymediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role inapoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. Thisfunction, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, maybe linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects theirorganization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thusNF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, butnot isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellulardomains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This processleads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylationCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Selectively inhibited by the enantiopure organoruthenium inhibitor 9E1. Activated following arsenictrioxide (As(2)O(3)) treatmentEnzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAOK2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAOK2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TAOK2 (NM_004783) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAOK2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAOK2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAOK2 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
TAOK2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TAOK2:
|
Pathways & Interactions
for TAOK2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | MAPK signaling pathway | | | 2 | p38 MAPK signaling pathway | | | 3 | Cytoskeleton remodeling Neurofilaments | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for TAOK2
2  BioSystems Pathways for TAOK2
1 
Kegg Pathway (Kegg details for TAOK2):
TAOK2 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TAOK2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 14)
5/17 Interacting proteins for TAOK2 (Q9UL543 ENSP000003100944) via UniProtKB, MINT, STRING, and/or I2D (see all 17)About this table
Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table
TAOK2 for ontologies About GeneDecksing
|
Drugs & Compounds
for TAOK2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TAOK2 for compounds About GeneDecksing
 Browse Tocris compounds for TAOK2
3 HMDB Compounds for TAOK2 About this table
1 DrugBank Compound for TAOK2 About this table
1 Novoseek chemical compound relationship for TAOK2 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| threonine |
39.7 |
1 |
11517310 (1) |
Search CenterWatch for drugs/clinical trials and news about TAOK2
|
Transcripts
for TAOK2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TAOK2 gene (3 alternative transcripts): NM_001252043.1 NM_004783.3 NM_016151.3 Unigene Cluster for TAOK2: TAO kinase 2 Hs.291623 [show with all ESTs]Unigene Representative Sequence: AF0619436 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000308893(uc002dvb.2 uc021tgf.1 uc002dva.2 uc010bzm.2)
ENST00000543033 ENST00000279394(uc002dvc.2) ENST00000416441(uc002dvd.2)
ENST00000566552 ENST00000570844
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAOK2 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAOK2 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TAOK2 (NM_004783) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAOK2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAOK2 |
Additional cDNA sequence: AB020688.1 AF061943.1 AF263313.1 AK291473.1 AK304446.1 AL137701.1 AY358942.1 BC015204.1 BC031825.2 BC051798.1 BC054495.1 BC136653.1 BC136655.1 BC142663.1 BC144344.1 BC151221.1 BC152413.1 12 DOTS entries: DT.95362553 DT.100754217 DT.100754216 DT.92049109 DT.95171410 DT.95171407 DT.100754213 DT.100754214 DT.100754215 DT.91831027 DT.95353472 DT.120696682 24/158 AceView cDNA sequences (see all 158): CA942054 BC051798 BM801657 AK057589 NM_016151 CB049752 BE044371 AI199772 AI637830 CO246565 CA952874 BX281468 BU165274 BM987557 CB155719 BU944035 NM_004783 AI679351 AI393849 AL137701 BC031825 BQ940691 AW196843 CA951161
GeneLoc Exon Structure
|
Expression
for TAOK2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TAOK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGCCAGGGG
About this image
See TAOK2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TAOK2
SOURCE GeneReport for Unigene cluster: Hs.291623
UniProtKB/Swiss-Prot: TAOK2_HUMAN, Q9UL54Tissue specificity: Ubiquitously expressed, with a higher level of expression in testis and brain
SABiosciences Custom PCR Arrays for TAOK2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAOK2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TAOK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAOK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAOK2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAOK2 |
Orthologs
for TAOK2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TAOK2 gene from 4/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
TAOK26 |
-- |
67(a) |
1 ↔ 1 |
GL343279.1(140591-152692) |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5642731 |
serine/threonine-protein kinase TAO2-like |
73.68(n)
80.47(a) |
|
564273 XM_687617.4 XP_692709.4 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Tao6 |
Tao |
38(a) |
1 → many |
X(19464418-19473841) |
worm
(Caenorhabditis elegans) |
Secernentea |
kin-186 |
Serine/threonine-protein kinase SULU |
31(a) |
1 → many |
III(6118580-6124015) |
ENSEMBL Gene Tree for TAOK2 (if available)
TreeFam Gene Tree for TAOK2 (if available) |
Paralogs
for TAOK2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TAOK2 gene
- MAP4K52 TAOK32 NRK2 TNIK2 MAP4K22 MAP4K12 MAP4K32 MAP4K42
- STK102 TAOK12 MINK12 SLK2
18/22 SIMAP similar genes for TAOK2 using alignment to 4 protein entries: TAOK2_HUMAN (see all proteins)
(see all similar genes):TAOK3 TAOK1 STK24 DKFZp686J1430 MST4 DKFZp564L2416
MST094 PAK4 STK11 STK3 MAP3K2 STK25
MAP2K5 MYO3A STK4 NEK7 MARK4 NEK6
TAOK2 for paralogs About GeneDecksing
|
Genomic Variants
for TAOK2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TAOK2 (29984962 - 30003582 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for TAOK2
1 CNV: 35383
4 Indels: 88062 88060 88061 77274 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAOK2 |
|
Disorders
/ Diseases
for TAOK2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TAOK2 for disorders About GeneDecksing
OMIM gene information: 613199
OMIM disorders: --
3  diseases for TAOK2: About MalaCardsprostatitis prostate carcinoma carcinoma
Human Genome Epidemiology (HuGE) Navigator: TAOK2 (1 document)
Export disorders for TAOK2 gene to outside databases
|
Publications
for TAOK2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TAOK2 gene, integrated from 9 sources (see all 37):
(articles sorted by number of sources associating them with TAOK2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T....Ohara O. (1998)
- The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability. (PubMed id 12639963)1, 2, 9 Mitsopoulos C.... Morris J.D. (2003)
- PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the JNK MAPK pathway and regulates actin cytoskeletal organisation. (PubMed id 10660600)1, 2, 9 Moore T.M....Morris J.D.H. (2000)
- Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK-and caspase-dependent nuclear localization is a requirement for membrane blebbing. (PubMed id 17158878)1, 2 Zihni C....Morris J.D. (2007)
- TAO kinases mediate activation of p38 in response to DNA damage. (PubMed id 17396146)1, 2 Raman M....Cobb M.H. (2007)
- Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways. (PubMed id 16893890)1, 2 Huangfu W.C.... Ninomiya-Tsuji J. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38. (PubMed id 13679851)1, 2 Yustein J.T....Kung H.-J. (2003)
- TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors. (PubMed id 12665513)1, 2 Chen Z....Cobb M.H. (2003)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
|
External Searches for TAOK2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TAOK2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TAOK2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing TAOK2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TAOK2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TAOK2 gene:
Search GeneIP for patents involving TAOK2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TAOK2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for TAOK2 | | OriGene shRNA RFP for TAOK2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TAOK2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAOK2 | | | OriGene Protein Over-expression Lysate for TAOK2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TAOK2 | | OriGene 3'-UTR Clone for TAOK2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAOK2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAOK2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TAOK2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TAOK2 | | OriGene Custom Protein Services for TAOK2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TAOK2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAOK2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAOK2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAOK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAOK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAOK2 |
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| | | | Search Tocris compounds for TAOK2 |
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 | | | TAOK2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAOK2 |
|  |  |  | | | | ThermoFisher Antibodies for TAOK2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAOK2 |
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