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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAOK2 Gene

protein-coding   GIFtS: 62
GCID: GC16P029985

TAO Kinase 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TAO Kinase 21 2     hKFC-C2 3
PSK2 3 5     EC 2.7.11.13 8
PSK12 3 5     TAO22 5
Kinase From Chicken Homolog C2 3     KIAA08813 5
Prostate-Derived STE20-Like Kinase 12 3     PSK1-BETA2
Prostate-Derived Sterile 20-Like Kinase 12 3     TAO12
Thousand And One Amino Acid Protein Kinase 22 3     Prostate Derived STE20-Like Kinase PSK2
MAP3K172 3     Serine/Threonine-Protein Kinase TAO22
PSK-12 3     EC 2.7.118

External Ids:    HGNC: 168351   Entrez Gene: 93442   Ensembl: ENSG000001499307   OMIM: 6131995   UniProtKB: Q9UL543   

Export aliases for TAOK2 gene to outside databases

Previous GC identifers: GC16P029892 GC16P027646


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TAOK2 Gene:
This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cell
signaling, microtubule organization and stability, and apoptosis. Alternatively spliced transcript variants
encoding different isoforms have been described for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for TAOK2 Gene: 
TAOK2 (TAO kinase 2) is a protein-coding gene. Diseases associated with TAOK2 include prostatitis, and autism spectrum disorder, and among its related super-pathways are MAPK signaling pathway and Cytoskeleton remodeling Neurofilaments. GO annotations related to this gene include protein serine/threonine kinase activity and mitogen-activated protein kinase kinase binding. An important paralog of this gene is MAP4K5.

UniProtKB/Swiss-Prot: TAOK2_HUMAN, Q9UL54
Function: Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic
bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself,
MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the
specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage,
involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade,
probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays
a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies
formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally
truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to
microtubules and affects their organization and stability independently of its kinase activity. Prevents
MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in
the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following
homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38
MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization.
Both isoforms are involved in MAPK14 phosphorylation

Gene Wiki entry for TAOK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAOK2 gene promoter:
         COUP-TF1   COUP-TF   p53   COUP   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAOK2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TAOK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAOK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

TAOK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAOK2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P029985:  view genomic region     (about GC identifiers)

Start:
29,984,962 bp from pter      End:
30,003,582 bp from pter
Size:
18,621 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TAOK2_HUMAN, Q9UL54 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase TAO2  
Size: 1235 amino acids; 138251 Da
Cofactor: Magnesium (By similarity)
Subunit: Interacts with MAP2K3 and MAP2K6 (By similarity). Self-associates. Interacts with tubulins through the
C-terminal domain. Interacts with MAP3K7 and interfers with MAP3K7-binding to CHUK and thus prevents NF-kappa-B
activation. Isoform 2 interacts with PCDH8; this complex may also include CDH2 (By similarity)
Subcellular location: Cytoplasmic vesicle membrane; Multi-pass membrane protein (Potential). Cytoplasm,
cytoskeleton. Nucleus. Note=Catalytically active full-length phosphorylated isoform 1 localizes to microtubules
in the cytoplasm predominantly on microtubule cables positioned around the nucleus. A C-terminally truncated form
of isoform 1 is present in the nucleus; isoform 2 and kinase-defective, as well as full-length isoform 1 are
excluded from the nucleus
Subcellular location: Isoform 2: Cell projection, dendrite. Note=In dendrites, colocalizes with PCDH8 (By
similarity)
Sequence caution: Sequence=AAQ89301.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA74904.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A5PKY1 A7MCZ2 B2RN35 B7ZM88 O94957 Q6UW73 Q7LC09 Q9NSW2
Alternative splicing: 4 isoforms:  Q9UL54-1   Q9UL54-2   Q9UL54-3   Q9UL54-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TAOK2: NX_Q9UL54

Explore proteomics data for TAOK2 at MOPED 

Post-translational modifications:

  • UniProtKB: Isoforms 1 and 2 are autophosphorylated
  • UniProtKB: C-terminal cleavage of isoform 1 and subsequent nuclear localization requires CASP9 activity
  • UniProtKB: Isoform 2 is phosphorylated at 'Ser-1031' by MAPK14. This phosphorylation is required PCDH8 for endocytosis (By
    similarity). Autophosphorylated. Phosphorylated by ATM
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UL54

  • 4/31 DME Specific Peptides for TAOK2 (Q9UL54) (see all 31)
     QEHEQDS  STPKREK  LQHQTEL  KAGNILL 

    TAOK2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TAOK2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001238972.1  NP_004774.1  NP_057235.2  

    ENSEMBL proteins: 
     ENSP00000310094   ENSP00000440336   ENSP00000279394   ENSP00000393048  

    Human Recombinant Protein Products for TAOK2: 
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    Cloud-Clone Corp. Proteins for TAOK2 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005856cytoskeleton IEA--
    GO:0016021integral to membrane IEA--

    TAOK2 for ontologies           About GeneDecksing



    TAOK2 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for TAOK2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: TAO kinase 2 
    TAO subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9UL54

    ProtoNet protein and cluster: Q9UL54

    UniProtKB/Swiss-Prot: TAOK2_HUMAN, Q9UL54
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 protein kinase domain


    TAOK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAOK2_HUMAN, Q9UL54
    Function: Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic
    bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself,
    MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the
    specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage,
    involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade,
    probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays
    a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies
    formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally
    truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to
    microtubules and affects their organization and stability independently of its kinase activity. Prevents
    MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in
    the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following
    homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38
    MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization.
    Both isoforms are involved in MAPK14 phosphorylation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Selectively inhibited by the enantiopure organoruthenium inhibitor 9E1. Activated following
    arsenic trioxide (As(2)O(3)) treatment

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA10660600
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
         
    TAOK2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TAOK2:
     Decreased focal adhesion (FA)  

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TAOK2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TAOK2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TAOK2 
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    miRNA
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    hsa-miR-100* hsa-miR-193a-3p hsa-miR-3194-5p hsa-miR-520e hsa-miR-1224-3p hsa-miR-106a hsa-miR-4305 hsa-miR-1260b
    SwitchGear 3'UTR luciferase reporter plasmidTAOK2 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TAOK2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2Cytoskeleton remodeling Neurofilaments
    Cytoplasmic microtubules0.32
    3p38 MAPK signaling pathway
    p38 MAPK signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TAOK2
        Cytoplasmic microtubules


    2 BioSystems Pathways for TAOK2
        MAPK signaling pathway
    p38 MAPK signaling pathway


    1         Kegg Pathway  (Kegg details for TAOK2):
        MAPK signaling pathway


    TAOK2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TAOK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/23 Interacting proteins for TAOK2 (Q9UL543 ENSP000003100944) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000232575P074373, ENSP000004100714I2D: score=1 STRING: ENSP00000410071
    ENSG00000183311P074373I2D: score=1 
    ENSG00000224156P074373I2D: score=1 
    ENSG00000227739P074373I2D: score=1 
    ENSG00000229684P074373I2D: score=1 
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity IDA10660600
    GO:0001558regulation of cell growth NAS10660600
    GO:0006468protein phosphorylation ----
    GO:0006612protein targeting to membrane NAS10660600
    GO:0006915apoptotic process NAS10660600

    TAOK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TAOK2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TAOK2

    3 HMDB Compounds for TAOK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    1 DrugBank Compound for TAOK2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Phosphonoserine-- --target--10592235

    1 Novoseek inferred chemical compound relationship for TAOK2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 39.7 1 11517310 (1)

    Search CenterWatch for drugs/clinical trials and news about TAOK2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TAOK2 gene (3 alternative transcripts): 
    NM_001252043.1  NM_004783.3  NM_016151.3  

    Unigene Cluster for TAOK2:

    TAO kinase 2
    Hs.291623  [show with all ESTs]
    Unigene Representative Sequence: AF061943
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308893(uc002dvb.2 uc021tgf.1 uc002dva.2 uc010bzm.2)
    ENST00000543033 ENST00000279394(uc002dvc.2) ENST00000416441(uc002dvd.2)
    ENST00000566552 ENST00000570844
    miRNA
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    Additional mRNA sequence: 

    AB020688.1 AF061943.1 AF263313.1 AK291473.1 AK304446.1 AL137701.1 AY358942.1 BC015204.1 
    BC031825.2 BC051798.1 BC054495.1 BC136653.1 BC136655.1 BC142663.1 BC144344.1 BC151221.1 
    BC152413.1 

    12 DOTS entries:

    DT.95362553  DT.100754217  DT.100754216  DT.92049109  DT.95171410  DT.95171407  DT.100754213  DT.100754214 
    DT.100754215  DT.91831027  DT.95353472  DT.120696682 

    24/158 AceView cDNA sequences (see all 158):

    AL137701 BQ940691 BM987557 NM_016151 BI256200 CB049752 BM801657 BU956237 
    AI393849 AB020688 BC031825 BX281468 AY358942 AI679351 CA952874 BE044371 
    AW196843 AI653873 BU165274 AK057589 NM_004783 CO246565 BU944035 CB155719 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TAOK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCCAGGGG
    TAOK2 Expression
    About this image


    See TAOK2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TAOK2

    SOURCE GeneReport for Unigene cluster: Hs.291623

    UniProtKB/Swiss-Prot: TAOK2_HUMAN, Q9UL54
    Tissue specificity: Ubiquitously expressed, with a higher level of expression in testis and brain

        SABiosciences Custom PCR Arrays for TAOK2
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAOK2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAOK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TAOK2 gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Taok21 , 5 TAO kinase 21, 5 90.42(n)1
    98.95(a)1
      7 (69.25 cM)5
    3819211  NM_001163774.11  NP_001157246.11 
     1268656785 
    lizard
    (Anolis carolinensis)
    Reptilia TAOK26
    TAO kinase 2
    65(a)
    1 ↔ 1
    GL343279.1(140550-161486)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5642731 serine/threonine-protein kinase TAO2-like 73.68(n)
    80.47(a)
      564273  XM_687617.4  XP_692709.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tao6
    Tao
    39(a)
    1 → many
    X(19464418-19473841)
    worm
    (Caenorhabditis elegans)
    Secernentea kin-186
    Serine/threonine-protein kinase SULU
    32(a)
    1 → many
    III(6118632-6124067)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SKM16
    CLA46
    Member of the PAK family of serine/threonine prote...
    Cdc42p-activated signal transducing kinase of the ...
    15(a)
    12(a)
    many ↔ many
    many ↔ many
    XV(104326-106293)
    XIV(68915-71443)


    ENSEMBL Gene Tree for TAOK2 (if available)
    TreeFam Gene Tree for TAOK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TAOK2 gene
    MAP4K52  TAOK32  NRK2  TNIK2  MAP4K22  MAP4K12  MAP4K32  MAP4K42  
    STK102  TAOK12  MINK12  SLK2  
    18/20 SIMAP similar genes for TAOK2 using alignment to 4 protein entries:     TAOK2_HUMAN (see all proteins) (see all similar genes):
    TAOK3    TAOK1    STK24    DKFZp686J1430    MST4    DKFZp564L2416
    MST094    PAK4    STK11    STK3    MAP3K2    STK25
    MAP2K5    MYO3A    STK4    NEK7    MARK4    NEK6

    TAOK2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/518 SNPs in TAOK2 are shown (see all 518)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1919932661,2
    --30882662(+) CCTTCC/GTGACA 3 -- us2k10--------
    rs1379044241,2
    --30883012(+) TCTAAC/TTGATG 3 -- us2k10--------
    rs1826119791,2
    --30883058(+) AACTTG/TACATG 3 -- us2k10--------
    rs1869679681,2
    --30883114(+) GATTCC/TGTTAA 3 -- us2k10--------
    rs1423357051,2
    --30883162(+) AGTGGA/GTGGGG 3 -- us2k10--------
    rs780739551,2
    C,F--30883345(+) GGGAAA/GAGTGG 3 -- us2k12Minor allele frequency- G:0.04WA EA 238
    rs119011,2
    C,F,O,A,H--30883481(-) GTTGAG/CAGGGT 3 -- us2k120Minor allele frequency- C:0.38MN NS EA NA CSA WA 1522
    rs1917537191,2
    --30883498(+) CTGGGA/CAAGGA 3 -- us2k10--------
    rs1505965861,2
    --30883567(+) TGCCCA/GTATTG 3 -- us2k10--------
    rs557436821,2
    C,F--30883784(+) CAGTGG/CCGTGT 3 -- us2k11Minor allele frequency- C:0.18NA 120

    HapMap Linkage Disequilibrium report for TAOK2 (29984962 - 30003582 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TAOK2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv997840CNV Deletion20482838
    dgv2668n71CNV Loss21882294
    nsv905717CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613199    OMIM disorders: --

    2 diseases for TAOK2:    About MalaCards
    prostatitis    autism spectrum disorder


    TAOK2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TAOK2
    Human Genome Epidemiology (HuGE) Navigator: TAOK2 (1 document)

    Export disorders for TAOK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TAOK2 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with TAOK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T....Ohara O. (1998)
    2. The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability. (PubMed id 12639963)1, 2, 9 Mitsopoulos C.... Morris J.D. (2003)
    3. PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the JNK MAPK pathway and regulates actin cytoskeletal organisation. (PubMed id 10660600)1, 2, 9 Moore T.M....Morris J.D.H. (2000)
    4. Association and mutation analyses of 16p11.2 autism candidate genes. (PubMed id 19242545)1, 4 Kumar R.A....Christian S.L. (2009)
    5. Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK-and caspase-dependent nuclear localization is a requirement for membrane blebbing. (PubMed id 17158878)1, 2 Zihni C....Morris J.D. (2007)
    6. TAO kinases mediate activation of p38 in response to DNA damage. (PubMed id 17396146)1, 2 Raman M....Cobb M.H. (2007)
    7. Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways. (PubMed id 16893890)1, 2 Huangfu W.C.... Ninomiya-Tsuji J. (2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38. (PubMed id 13679851)1, 2 Yustein J.T....Kung H.-J. (2003)
    10. TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors. (PubMed id 12665513)1, 2 Chen Z....Cobb M.H. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9344 HGNC: 16835 AceView: TAO1 Ensembl:ENSG00000149930 euGenes: HUgn9344
    ECgene: TAOK2 Kegg: 9344 H-InvDB: TAOK2

    (According to HUGE)
    About This Section
    HUGE: KIAA0881

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TAOK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TAOK2 gene:
    Search GeneIP for patents involving TAOK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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