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Aliases for TAOK2 Gene

Aliases for TAOK2 Gene

  • TAO Kinase 2 2 3
  • PSK1 3 4 6
  • PSK 3 4 6
  • Thousand And One Amino Acid Protein Kinase 2 3 4
  • Prostate-Derived Sterile 20-Like Kinase 1 3 4
  • Prostate-Derived STE20-Like Kinase 1 3 4
  • Kinase From Chicken Homolog C 3 4
  • EC 2.7.11.1 4 64
  • KIAA0881 4 6
  • MAP3K17 3 4
  • HKFC-C 3 4
  • PSK-1 3 4
  • TAO2 3 6
  • Prostate Derived STE20-Like Kinase PSK 3
  • Serine/Threonine-Protein Kinase TAO2 3
  • PSK1-BETA 3
  • EC 2.7.11 64
  • TAO1 3

External Ids for TAOK2 Gene

Summaries for TAOK2 Gene

Entrez Gene Summary for TAOK2 Gene

  • This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cell signaling, microtubule organization and stability, and apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for TAOK2 Gene

TAOK2 (TAO Kinase 2) is a Protein Coding gene. Among its related pathways are MAPK signaling pathway and MAPK signaling pathway. GO annotations related to this gene include protein serine/threonine kinase activity and mitogen-activated protein kinase kinase binding. An important paralog of this gene is MAP4K3.

UniProtKB/Swiss-Prot for TAOK2 Gene

  • Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation.

Gene Wiki entry for TAOK2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAOK2 Gene

Genomics for TAOK2 Gene

Genomic Location for TAOK2 Gene

Start:
29,973,641 bp from pter
End:
29,992,261 bp from pter
Size:
18,621 bases
Orientation:
Plus strand

Genomic View for TAOK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAOK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAOK2 Gene

Regulatory Elements for TAOK2 Gene

Proteins for TAOK2 Gene

  • Protein details for TAOK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL54-TAOK2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase TAO2
    Protein Accession:
    Q9UL54
    Secondary Accessions:
    • A5PKY1
    • A7MCZ2
    • B2RN35
    • B7ZM88
    • O94957
    • Q6UW73
    • Q7LC09
    • Q9NSW2

    Protein attributes for TAOK2 Gene

    Size:
    1235 amino acids
    Molecular mass:
    138251 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with MAP2K3 and MAP2K6 (By similarity). Self-associates. Interacts with tubulins through the C-terminal domain. Interacts with MAP3K7 and interfers with MAP3K7-binding to CHUK and thus prevents NF-kappa-B activation. Isoform 2 interacts with PCDH8; this complex may also include CDH2 (By similarity).
    SequenceCaution:
    • Sequence=AAQ89301.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA74904.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TAOK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAOK2 Gene

Proteomics data for TAOK2 Gene at MOPED

Post-translational modifications for TAOK2 Gene

  • Autophosphorylated. Phosphorylated by ATM
  • C-terminal cleavage of isoform 1 and subsequent nuclear localization requires CASP9 activity
  • Isoform 2: Phosphorylated on Ser-1031 by MAPK14. This phosphorylation is required PCDH8 for endocytosis (By similarity).
  • Isoforms 1 and 2 are autophosphorylated
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAOK2 Gene

Domains for TAOK2 Gene

Gene Families for TAOK2 Gene

UniProtKB/Swiss-Prot:

TAOK2_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q9UL54
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.:
    • Q9UL54
genes like me logo Genes that share domains with TAOK2: view

Function for TAOK2 Gene

Molecular function for TAOK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Selectively inhibited by the enantiopure organoruthenium inhibitor 9E1. Activated following arsenic trioxide (As(2)O(3)) treatment.
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation.

Enzyme Numbers (IUBMB) for TAOK2 Gene

Gene Ontology (GO) - Molecular Function for TAOK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 10660600
GO:0004709 MAP kinase kinase kinase activity IBA --
GO:0004713 protein tyrosine kinase activity --
genes like me logo Genes that share ontologies with TAOK2: view

Phenotypes for TAOK2 Gene

MGI mutant phenotypes for TAOK2:
inferred from 2 alleles
GenomeRNAi human phenotypes for TAOK2:
genes like me logo Genes that share phenotypes with TAOK2: view

miRNA for TAOK2 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TAOK2 Gene

Localization for TAOK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAOK2 Gene

Cytoplasmic vesicle membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton. Nucleus. Note=Catalytically active full-length phosphorylated isoform 1 localizes to microtubules in the cytoplasm predominantly on microtubule cables positioned around the nucleus. A C-terminally truncated form of isoform 1 is present in the nucleus; isoform 2 and kinase-defective, as well as full-length isoform 1 are excluded from the nucleus.
Isoform 2: Cell projection, dendrite. Note=In dendrites, colocalizes with PCDH8. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAOK2 Gene COMPARTMENTS Subcellular localization image for TAOK2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TAOK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005856 cytoskeleton IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TAOK2: view

Pathways for TAOK2 Gene

genes like me logo Genes that share pathways with TAOK2: view

Pathways by source for TAOK2 Gene

2 BioSystems pathways for TAOK2 Gene
1 KEGG pathway for TAOK2 Gene

Gene Ontology (GO) - Biological Process for TAOK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000186 activation of MAPKK activity IDA 10660600
GO:0001558 regulation of cell growth NAS 10660600
GO:0006468 protein phosphorylation IEA --
GO:0006612 protein targeting to membrane NAS 10660600
GO:0006915 apoptotic process NAS 10660600
genes like me logo Genes that share ontologies with TAOK2: view

Compounds for TAOK2 Gene

(3) HMDB Compounds for TAOK2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4

(1) Drugbank Compounds for TAOK2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Phosphonoserine
target

(1) Novoseek inferred chemical compound relationships for TAOK2 Gene

Compound -log(P) Hits PubMed IDs
threonine 39.7 1
genes like me logo Genes that share compounds with TAOK2: view

Transcripts for TAOK2 Gene

Unigene Clusters for TAOK2 Gene

TAO kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAOK2 Gene

No ASD Table

Relevant External Links for TAOK2 Gene

GeneLoc Exon Structure for
TAOK2
ECgene alternative splicing isoforms for
TAOK2

Expression for TAOK2 Gene

mRNA expression in normal human tissues for TAOK2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TAOK2 Gene

SOURCE GeneReport for Unigene cluster for TAOK2 Gene Hs.291623

mRNA Expression by UniProt/SwissProt for TAOK2 Gene

Q9UL54-TAOK2_HUMAN
Tissue specificity: Ubiquitously expressed, with a higher level of expression in testis and brain.
genes like me logo Genes that share expressions with TAOK2: view

Orthologs for TAOK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TAOK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAOK2 37
  • 85 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAOK2 36
  • 93.2 (n)
  • 99.24 (a)
TAOK2 37
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAOK2 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taok2 36
  • 90.1 (n)
  • 98.19 (a)
Taok2 16
Taok2 37
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAOK2 37
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAOK2 37
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAOK2 37
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia taok2 36
  • 75.25 (n)
  • 82.9 (a)
zebrafish
(Danio rerio)
Actinopterygii taok2a 37
  • 56 (a)
OneToMany
taok2b 36
  • 72.65 (n)
  • 79.03 (a)
taok2b 37
  • 57 (a)
OneToMany
taok2b 37
  • 57 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Tao 37
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea kin-18 37
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 29 (a)
OneToMany
Species with no ortholog for TAOK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAOK2 Gene

ENSEMBL:
Gene Tree for TAOK2 (if available)
TreeFam:
Gene Tree for TAOK2 (if available)

Paralogs for TAOK2 Gene

Paralogs for TAOK2 Gene

genes like me logo Genes that share paralogs with TAOK2: view

Variants for TAOK2 Gene

Sequence variations from dbSNP and Humsavar for TAOK2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs3814881 -- 29,989,580(-) GTGGA(C/T)GGATC intron-variant
rs3814882 -- 29,987,957(-) GGCCC(A/G)GGACT reference, missense, intron-variant
rs3814883 -- 29,983,601(-) CGGGC(A/G)GAAGA reference, synonymous-codon
rs3814884 -- 29,983,415(-) AGAGG(A/T)GTGCT intron-variant
rs4077410 -- 29,986,879(+) GGGAC(A/G)TGGAG reference, synonymous-codon, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAOK2 Gene

Variant ID Type Subtype PubMed ID
nsv905717 CNV Loss 21882294
dgv2668n71 CNV Loss 21882294
esv997840 CNV Deletion 20482838

Relevant External Links for TAOK2 Gene

HapMap Linkage Disequilibrium report
TAOK2

Disorders for TAOK2 Gene

Relevant External Links for TAOK2

Genetic Association Database (GAD)
TAOK2
Human Genome Epidemiology (HuGE) Navigator
TAOK2
genes like me logo Genes that share disorders with TAOK2: view

No data available for UniProtKB/Swiss-Prot for TAOK2 Gene

Publications for TAOK2 Gene

  1. The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability. (PMID: 12639963) Mitsopoulos C. … Morris J.D. (J. Biol. Chem. 2003) 3 4 23
  2. PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the JNK MAPK pathway and regulates actin cytoskeletal organisation. (PMID: 10660600) Moore T.M. … Morris J.D.H. (J. Biol. Chem. 2000) 3 4 23
  3. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  4. Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2. (PMID: 11279118) Chen Z. … Cobb M.H. (J. Biol. Chem. 2001) 3 4
  5. TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors. (PMID: 12665513) Chen Z. … Cobb M.H. (J. Biol. Chem. 2003) 3 4

Products for TAOK2 Gene

Sources for TAOK2 Gene

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