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TAOK2 Gene

protein-coding   GIFtS: 57

GC16P029892
TAO kinase 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
EC 2.7.11.1 3
KIAA0881 1, 2, 3
MAP3K17 1, 2, 3
PSK 1, 2, 3
PSK-1 3
PSK1 1, 2, 3
TAO1 1, 2
TAO2 1, 2
hKFC-C 3
Descriptions
Kinase from chicken homolog C 3
Prostate-derived STE20-like kinase 1 3
TAO kinase 2 2
Thousand and one amino acid protein 2 3
prostate derived STE20-like kinase PSK 2
thousand and one amino acid protein kinase 2
External Ids
HGNC: 168351
Entrez Gene: 93442
UniProtKB: Q9UL543
Ensembl: ENSG000001499307
Search outside databases for aliases for TAOK2 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: TAOK2_HUMAN, Q9UL54
Function: Activates the JNK MAP kinase pathway through the specific activation of the upstream MKK3
and MKK6 kinases

Gene Wiki entry for TAOK2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the TAOK2 gene  

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

TAOK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P029892:     (about GC identifiers)

Start:
29,892,723 bp from pter
End:
29,911,082 bp from pter
Size:
18,360 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000016.8  NT_010393.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TAOK2_HUMAN, Q9UL54 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase TAO2  
Size: 1235 amino acids; 138251 Da
Cofactor: Magnesium (By similarity)
Subunit: Interacts with MKK3 and MKK6 (By similarity). Self-associates
Subcellular location: Cytoplasmic vesicle membrane; Multi-pass membrane protein (Potential).
Note=Found to be perinuclear and localized to vesicular compartment
Secondary accessions: O94957 Q6UW73 Q7LC09 Q9NSW2
Alternative splicing: 3 isoforms:  Q9UL54-1   Q9UL54-2   Q9UL54-3   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_004774.1  NP_057235.2  


    ENSEMBL proteins: 
    ENSP00000310094 ENSP00000279394 


    Human Recombinant Proteins 
    Invitrogen human recombinant proteins for TAOK2
    Millipore Purified and/or Recombinant TAOK2 Protein
    Sigma-Aldrich Proteins for TAOK2  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (TAO kinase 2 )
    Human Recombinant Proteins from Abnova (TAOK2)
                  OriGene Purified Recombinant Human Protein: TAOK2 

    5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IDA18029348
    GO:0005730 nucleolus IDA18029348
    GO:0005737 cytoplasm IDA18029348
    GO:0016020 membrane IEA--
    GO:0016021 integral to membrane IEA--
    About this table

    Antibodies for TAOK2: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for TAOK2
    R&D Systems Antibodies for TAOK2 (TAO2)
    Antibodies from Abcam (TAO kinase 2 ), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (TAOK2)
    Novus Biologicals Antibodies for TAOK2

    Assays for TAOK2: 
    Invitrogen Assays for TAOK2
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser_thr_pkinase
     IPR017442 Se/Thr_pkinase-rel
     IPR008271 Ser_thr_pkin_AS
     IPR000719 Prot_kinase_core


       GeneDecks  TAOK2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9UL54

    ProtoNet protein and cluster: Q9UL54

    UniProtKB/Swiss-Prot: TAOK2_HUMAN, Q9UL54
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20
    subfamily
    Similarity: Contains 1 protein kinase domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (TAOK2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (TAOK2)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_004783

                  Applied Biosystems Silencer® siRNAs for TAOK2

                  Sigma-Aldrich siRNA and siRNA Panels for TAOK2  
                         Sigma-Aldrich shRNA Panels and shRNA for TAOK2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004783
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004783
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_004783 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_016151

    UniProtKB/Swiss-Prot: TAOK2_HUMAN, Q9UL54
    Function: Activates the JNK MAP kinase pathway through the specific activation of the upstream MKK3
    and MKK6 kinases
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme Number (IUBMB): EC 2.7.11.1 

    5 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0000287 magnesium ion binding IEA--
    GO:0004674 protein serine/threonine kinase activity IDA10660600
    GO:0005524 ATP binding IEA--
    GO:0016740 transferase activity IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Millipore Pathway for TAOK2
     Cytoplasmic microtubules

       GeneDecks  TAOK2 for the pathways selected above  
    About GeneDecksing

    1 Kegg Pathway  (Kegg details for TAOK2):
     hsa04010 MAPK signaling pathway

       GeneDecks  TAOK2 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  TAOK2 


    5/17 Interacting proteins for TAOK2 (ENSP000003100943) via UniProtKB, MINT, and/or STRING (see all 17 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP2K3ENSP000003191393STRING (score=.99)
    MAP2K6ENSP000003519973STRING (score=.988)
    BUB1BENSP000002875983STRING (score=.923)
    TAOK1ENSP000002617163STRING (score=.905)
    MBPENSP000003482733STRING (score=.888)
    About this table

    5/10 Gene Ontology (GO) biological process terms (links to tree view) (see all 10 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186 activation of MAPKK activity IDA10660600
    GO:0001558 regulation of cell growth NAS10660600
    GO:0006612 protein targeting to membrane NAS10660600
    GO:0006915 apoptosis NAS10660600
    GO:0006950 response to stress IDA10660600
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for TAOK2
    1 Novoseek chemical compound relationship for TAOK2 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 40.49 1 11517310 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (TAOK2)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (TAOK2)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_004783

                  Sigma-Aldrich siRNA and siRNA Panels for TAOK2  
                         Sigma-Aldrich shRNA Panels and shRNA for TAOK2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_004783  NM_016151  

    REFSEQ mRNAs for TAOK2 gene (2 alternative transcripts): 

    NM_004783.2   NM_016151.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_004783  NM_016151  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004783
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004783
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_004783 

    Additional cDNA sequence: 

    AB020688.1 AF061943.1 AF263313.1 AK291473.1 AK304446.1 AL137701.1 AY358942.1 BC015204.1 
    BC031825.2 BC051798.1 BC054495.1 BC136653.1 BC136655.1 BC142663.1 BC144344.1 BC151221.1 
    BC152413.1 

    12 DOTS entries:

    DT.95362553  DT.100754217  DT.100754216  DT.92049109  DT.95171410  DT.95171407  DT.100754213  DT.100754214 
    DT.100754215  DT.91831027  DT.95353472  DT.120696682 

    24/158 AceView cDNA sequences (see all 158 ):

    AB020688 CA952874 NM_004783 CO246565 AI653873 CA942054 BU956237 BU944035 
    CD671176 AL137701 AI637830 BQ940691 BC015204 BC051798 BM801657 BM987557 
    BE044371 AK057589 BC031825 AI679351 BI256200 NM_016151 BX281468 CB155719 

    highest scoring ESTs for TAOK2:

    AB020688 AA315359 AF263313 AI262128 AI520901 AI637830 AI655230 AI805725 AI825004 AI953268 

    Unigene Cluster for TAOK2:

    TAO kinase 2
    Hs.291623  [show with all ESTs]
    Unigene Representative Sequence: AF061943


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000308893  ENST00000279394  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    TAOK2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for TAOK2

    1 / 2 / 3

    8 probe-sets matching TAOK2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    46609_at2, 3 U95-B 1 1.00 1.00 0.35 1.13 AL048835 0.80 1.00 0.91 1
    37771_at2, 3 U95-A 1 1.00 1.00 0.86 0.87 AB020688 1.00 1.00 1.00 1

    204878_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_004783 0.60 1.00 0.82 1

    204986_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_016151 0.60 1.00 0.82 1

    204877_s_at2, 3 U133-A 1 1.00 1.00 -- -- AW007163 0.40 1.00 0.76 1

    204878_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    204986_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    204877_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  TAOK2 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GTGCCAGGGG

    SOURCE GeneReport for Unigene cluster: Hs.291623

    UniProtKB/Swiss-Prot: TAOK2_HUMAN, Q9UL54
    Tissue specificity: Ubiquitously expressed, with a higher level of expression in testis and brain

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for TAOK2 gene from 4 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    TAOK21   -- TAO kinase 2 92.52(n)
    99.33(a)
    489943  XM_853393.1  XP_858486.1 
    cow
    (Bos taurus)
    TAOK21   -- TAO kinase 2 93.2(n)
    99.24(a)
    533897  XM_867776.2  XP_872869.2 
    mouse
    (Mus musculus)
    Taok25 7 TAO kinase 2   -- BG080542 
    zebrafish
    (Danio rerio)
    LOC5561721   -- similar to TAO kinase 2 72.42(n)
    79.56(a)
    556172  XM_678910.2  XP_684002.2 
    About this table        Species with no ortholog for TAOK2

    ENSEMBL Gene Tree for TAOK2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for TAOK2 gene
    TAOK32  TAOK12  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/82 NCBI SNPs in TAOK2 are shown (see all 82 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 49)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 16 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs99246861,2
    A,C,F,H29910577(+) GATAGG/ATGCCT 1 -- ut31 ese34Minor allele frequency- A:0.33EU EA WA 418
    rs47874901,2
    C,F,H29910906(+) TTGTCC/GTTTAT 1 -- ut31 ese37Minor allele frequency- G:0.01EU EA WA NA 558
    --
    rs118641491,2
    C29906726(+) CTCCCA/GCCAGC 2 R/H mis1 int1 ese30--------
    --
    rs104451051,2
    C29906989(+) GTCACG/TCTGTG 2 -- ut31 int1 ese30--------
    rs40774101,2
    A,C,F,H29905701(+) GGGACA/GTGGAG 2 T/T syn1 int14Minor allele frequency- G:0.48EU EA WA 412
    rs38148831,2
    A,C,F,H29902423(-) CGGGCG/AGAAGA 2 S/S syn1 ese39Minor allele frequency- A:0.40EA EU WA 2326
    rs47874891,2
    A,C,F,H29903381(+) TGTGCG/AGTACT 2 -- int14Minor allele frequency- A:0.31EU EA WA 396
    rs99259151,2
    A,C,F,H29901187(+) GAGCCG/CTAGTT 2 -- int18Minor allele frequency- C:0.40EU EA WA 830
    rs47882041,2
    A,C,F,H29902719(+) ACTCCG/ATTTTT 2 -- int17Minor allele frequency- A:0.41NA EU EA WA 520
    rs45832551,2
    A,C,F,H29896442(-) ACTGCT/CGAGGA 2 -- int17Minor allele frequency- C:0.33EU EA WA NA 560
    About this table

    HapMap Linkage Disequilibrium images for TAOK2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    Human Genome Epidemiology Navigator: TAOK2 (1 document)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/23 PubMed articles for TAOK2 gene (see all 23 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 9344 HGNC: 16835 AceView: TAO1 Ensembl:ENSG00000149930 euGenes: HUgn9344
    ECgene: TAOK2 H-InvDB: TAOK2
    (According to HUGE)
    About This Section

    HUGE: KIAA0881
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for TAOK2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for TAOK2-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for TAOK2 Antibodies for TAOK2
     Explore super-pooled esiRNAs Proteins for TAOK2
     Lentivirus-delivered shRNAs for TAOK2 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
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     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (TAOK2)
     Antibodies (TAOK2)
     Chimera RNAi (TAOK2)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (TAO kinase 2 )
     Antibodies (TAO kinase 2 )
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for TAOK2




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for TAOK2

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