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Aliases & Descriptions for TAOK2
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases EC 2.7.11.1 3 KIAA0881 1 , 2 , 3 MAP3K17 1 , 2 , 3 PSK 1 , 2 , 3 PSK-1 3 PSK1 1 , 2 , 3 TAO1 1 , 2 TAO2 1 , 2 hKFC-C 3
Descriptions Kinase from chicken homolog C 3 Prostate-derived STE20-like kinase 1 3 TAO kinase 2 2 Thousand and one amino acid protein 2 3 prostate derived STE20-like kinase PSK 2 thousand and one amino acid protein kinase 2
Search outside databases for aliases for TAOK2 gene
Summaries for TAOK2 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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UniProtKB/Swiss-Prot: TAOK2_HUMAN, Q9UL54 Function : Activates the JNK MAP kinase pathway through the specific activation of the upstream MKK3and MKK6 kinases
Gene Wiki entry for TAOK2
Genomic Location for TAOK2
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the TAOK2 gene Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2 TAOK2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure
GeneLoc location for GC16P029892:
(about GC identifiers )
Start:
29,892,723 bp from pter
End:
29,911,082 bp from pter
Size:
18,360 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000016.8 NT_010393.15 Proteins for TAOK2
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: TAOK2_HUMAN, Q9UL54 (See
protein sequence )Recommended Name: Serine/threonine-protein kinase TAO2 Size : 1235 amino acids; 138251 Da
Cofactor : Magnesium (By similarity)
Subunit : Interacts with MKK3 and MKK6 (By similarity). Self-associates
Subcellular location : Cytoplasmic vesicle membrane; Multi-pass membrane protein (Potential).Note=Found to be perinuclear and localized to vesicular compartment
Secondary accessions : O94957 Q6UW73 Q7LC09 Q9NSW2Alternative splicing : 3 isoforms : Q9UL54-1 Q9UL54-2 Q9UL54-3
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_004774.1 NP_057235.2 ENSEMBL proteins: ENSP00000310094 ENSP00000279394 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: TAOK2 5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6
):
About this table Antibodies for TAOK2: Assays for TAOK2:
Protein
Domains/ Families for TAOK2(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9UL54 ProtoNet protein and cluster: Q9UL54
UniProtKB/Swiss-Prot: TAOK2_HUMAN, Q9UL54 Similarity : Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20subfamily Similarity : Contains 1 protein kinase domain
Gene Function for TAOK2
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_004783 Applied Biosystems Silencer ® siRNAs for TAOK2 Sigma-Aldrich siRNA and siRNA Panels for TAOK2 Sigma-Aldrich shRNA Panels and shRNA for TAOK2 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_004783                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_004783                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_004783  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_016151 UniProtKB/Swiss-Prot: TAOK2_HUMAN, Q9UL54 Function : Activates the JNK MAP kinase pathway through the specific activation of the upstream MKK3and MKK6 kinases Catalytic activity : ATP + a protein = ADP + a phosphoproteinEnzyme Number (IUBMB): EC 2.7.11.1
5 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for TAOK2
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for TAOK2 5/17 Interacting proteins for TAOK2 (ENSP00000310094 3 ) via UniProtKB, MINT, and/or STRING (see all 17
)About this table 5/10 Gene Ontology (GO) biological process terms (links to tree view) (see all 10
):
About this table
Drugs & Compounds for TAOK2 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for TAOK2 1 Novoseek chemical compound relationship for TAOK2 gene
Compound
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
threonine
40.49
1
11517310 (1)
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Transcripts for TAOK2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_004783 Sigma-Aldrich siRNA and siRNA Panels for TAOK2 Sigma-Aldrich shRNA Panels and shRNA for TAOK2 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_004783 NM_016151
REFSEQ mRNAs for TAOK2 gene (2 alternative transcripts): NM_004783.2 NM_016151.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004783 NM_016151
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_004783                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_004783                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_004783  
Additional cDNA sequence: AB020688.1 AF061943.1 AF263313.1 AK291473.1 AK304446.1 AL137701.1 AY358942.1 BC015204.1 BC031825.2 BC051798.1 BC054495.1 BC136653.1 BC136655.1 BC142663.1 BC144344.1 BC151221.1 BC152413.1
12 DOTS entries : DT.95362553 DT.100754217 DT.100754216 DT.92049109 DT.95171410 DT.95171407 DT.100754213 DT.100754214 DT.100754215 DT.91831027 DT.95353472 DT.120696682
24/158 AceView cDNA sequences (see all 158
):AB020688 CA952874 NM_004783 CO246565 AI653873 CA942054 BU956237 BU944035 CD671176 AL137701 AI637830 BQ940691 BC015204 BC051798 BM801657 BM987557 BE044371 AK057589 BC031825 AI679351 BI256200 NM_016151 BX281468 CB155719
highest scoring ESTs for TAOK2 :AB020688 AA315359 AF263313 AI262128 AI520901 AI637830 AI655230 AI805725 AI825004 AI953268
Unigene Cluster for TAOK2: TAO kinase 2 Hs.291623 [show with all ESTs ] Unigene Representative Sequence: AF061943 GeneLoc Exon Structure 2 Ensembl transcripts including schematic representations : ENST00000308893
ENST00000279394
Expression for TAOK2
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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TAOK2 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for TAOK2 1 / 2 / 3
8 probe-sets matching TAOK2 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GTGCCAGGGGSOURCE GeneReport for Unigene cluster: Hs.291623 UniProtKB/Swiss-Prot: TAOK2_HUMAN, Q9UL54 Tissue specificity : Ubiquitously expressed, with a higher level of expression in testis and brain
Orthologs for TAOK2
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for TAOK2 gene from 4 species
About this table Species with no ortholog for TAOK2 ENSEMBL Gene Tree for TAOK2 Paralogs for TAOK2 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for TAOK2 gene TAOK3 2 TAOK1 2
SNPs/Variants for TAOK2 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for TAOK2 (up to first 250kb)
Disorders & Mutations for TAOK2
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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Human Genome Epidemiology Navigator: TAOK2 (1 document)
Medical News for TAOK2 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for TAOK2 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/23 PubMed articles for TAOK2 gene (see all 23
): Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485) 2, 3, 4 Nagase T....Ohara O. (1998) PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the JNK MAPK pathway and regulates actin cytoskeletal organisation. (PubMed id 10660600) 1, 3, 4 Moore T.M....Morris J.D.H. (2000) Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38. (PubMed id 13679851) 3, 4 Yustein J.T....Kung H.-J. (2003) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 3, 4 Clark H.F....Gray A. (2003) Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades. (PubMed id 9786855) 2, 3 Hutchison M....Cobb M.H. (1998) The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability. (PubMed id 12639963) 1, 3 Mitsopoulos C....Morris J.D. (2003) Association and mutation analyses of 16p11.2 autism candidate genes. (PubMed id 19242545) 3 Kumar R.A....Christian S.L. (2009) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 3 Barbe L....Andersson-Svahn H. (2008) Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976) 4 Daub H.... Mann M. (2008) Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK- and caspase-dependent nuclear localization is a requirement for membrane blebbing. (PubMed id 17158878) 3 Zihni C....Morris J.D. (2007)
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Genome Databases showing TAOK2
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing TAOK2
(According to HUGE )
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Specialized Databases showing TAOK2 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for TAOK2 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for TAOK2:
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