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TAOK2 Gene

protein-coding   GIFtS: 61
GCID: GC16P029985

TAO Kinase 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TAO Kinase 21 2     hKFC-C2 3
PSK2 3 5     EC 2.7.11.13 8
PSK12 3 5     TAO22 5
Kinase From Chicken Homolog C2 3     KIAA08813 5
Prostate-Derived STE20-Like Kinase 12 3     PSK1-BETA2
Prostate-Derived Sterile 20-Like Kinase 12 3     TAO12
Thousand And One Amino Acid Protein Kinase 22 3     Prostate Derived STE20-Like Kinase PSK2
MAP3K172 3     Serine/Threonine-Protein Kinase TAO22
PSK-12 3     EC 2.7.118

External Ids:    HGNC: 168351   Entrez Gene: 93442   Ensembl: ENSG000001499307   OMIM: 6131995   UniProtKB: Q9UL543   

Export aliases for TAOK2 gene to outside databases

Previous GC identifers: GC16P029892 GC16P027646


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TAOK2 Gene:
This gene encodes a serine/threonine protein kinase that is involved in many different processes, including, cell
signaling, microtubule organization and stability, and apoptosis. Alternatively spliced transcript variants
encoding different isoforms have been described for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for TAOK2 Gene:
TAOK2 (TAO kinase 2) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and mitogen-activated protein kinase kinase binding. An important paralog of this gene is MAP4K5.

UniProtKB/Swiss-Prot: TAOK2_HUMAN, Q9UL54
Function: Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic
bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself,
MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the
specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage,
involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade,
probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays
a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies
formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally
truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to
microtubules and affects their organization and stability independently of its kinase activity. Prevents
MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in
the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following
homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38
MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization.
Both isoforms are involved in MAPK14 phosphorylation

Gene Wiki entry for TAOK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the TAOK2 gene promoter:
         COUP-TF1   COUP-TF   p53   COUP   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAOK2 promoter sequence
   Search Chromatin IP Primers for TAOK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAOK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

TAOK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAOK2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P029985:  view genomic region     (about GC identifiers)

Start:
29,984,962 bp from pter      End:
30,003,582 bp from pter
Size:
18,621 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TAOK2_HUMAN, Q9UL54 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase TAO2  
Size: 1235 amino acids; 138251 Da
Cofactor: Magnesium (By similarity)
Subunit: Interacts with MAP2K3 and MAP2K6 (By similarity). Self-associates. Interacts with tubulins through the
C-terminal domain. Interacts with MAP3K7 and interfers with MAP3K7-binding to CHUK and thus prevents NF-kappa-B
activation. Isoform 2 interacts with PCDH8; this complex may also include CDH2 (By similarity)
Sequence caution: Sequence=AAQ89301.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAA74904.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A5PKY1 A7MCZ2 B2RN35 B7ZM88 O94957 Q6UW73 Q7LC09 Q9NSW2
Alternative splicing: 4 isoforms:  Q9UL54-1   Q9UL54-2   Q9UL54-3   Q9UL54-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TAOK2: NX_Q9UL54

Explore proteomics data for TAOK2 at MOPED

Post-translational modifications: 

  • Isoforms 1 and 2 are autophosphorylated1
  • C-terminal cleavage of isoform 1 and subsequent nuclear localization requires CASP9 activity1
  • Autophosphorylated. Phosphorylated by ATM1
  • Isoform 2: Phosphorylated on Ser-1031 by MAPK14. This phosphorylation is required PCDH8 for endocytosis (By
    similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TAOK2 (Q9UL54) (see all 31)
     QEHEQDS  STPKREK  LQHQTEL  KAGNILL 


    See TAOK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001238972.1  NP_004774.1  NP_057235.2  

    ENSEMBL proteins: 
     ENSP00000310094   ENSP00000440336   ENSP00000279394   ENSP00000393048  

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    antibodies-online proteins for TAOK2 (2 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: TAO kinase 2
    TAO subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q9UL54

    ProtoNet protein and cluster: Q9UL54

    UniProtKB/Swiss-Prot: TAOK2_HUMAN, Q9UL54
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with TAOK2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAOK2_HUMAN, Q9UL54
    Function: Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic
    bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself,
    MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the
    specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage,
    involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade,
    probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays
    a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies
    formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C-terminally
    truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to
    microtubules and affects their organization and stability independently of its kinase activity. Prevents
    MAP3K7-mediated activation of CHUK, and thus NF-kappa-B activation, but not that of MAPK8/JNK. May play a role in
    the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following
    homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38
    MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization.
    Both isoforms are involved in MAPK14 phosphorylation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Selectively inhibited by the enantiopure organoruthenium inhibitor 9E1. Activated following
    arsenic trioxide (As(2)O(3)) treatment

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA10660600
    GO:0004709MAP kinase kinase kinase activity IBA--
    GO:0004713protein tyrosine kinase activity ----
         
    Find genes that share ontologies with TAOK2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TAOK2:
     Decreased focal adhesion (FA)  

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Taok2):
     behavior/neurological  homeostasis/metabolism 

    Find genes that share phenotypes with TAOK2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TAOK2

    miRNA
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    miRTarBase miRNAs that target TAOK2:
    hsa-mir-484 (MIRT042035), hsa-mir-769-5p (MIRT016093), hsa-mir-92a-3p (MIRT049049), hsa-mir-331-3p (MIRT043319)

    Block miRNA regulation of human, mouse, rat TAOK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TAOK2 (see all 64):
    hsa-miR-100* hsa-miR-193a-3p hsa-miR-3194-5p hsa-miR-520e hsa-miR-1224-3p hsa-miR-106a hsa-miR-4305 hsa-miR-1260b
    SwitchGear 3'UTR luciferase reporter plasmidTAOK2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TAOK2_HUMAN, Q9UL54: Cytoplasmic vesicle membrane; Multi-pass membrane protein (Potential). Cytoplasm,
    cytoskeleton. Nucleus. Note=Catalytically active full-length phosphorylated isoform 1 localizes to microtubules
    in the cytoplasm predominantly on microtubule cables positioned around the nucleus. A C-terminally truncated form
    of isoform 1 is present in the nucleus; isoform 2 and kinase-defective, as well as full-length isoform 1 are
    excluded from the nucleus
    TAOK2_HUMAN, Q9UL54: Isoform 2: Cell projection, dendrite. Note=In dendrites, colocalizes with PCDH8 (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol3
    plasma membrane3

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005856cytoskeleton IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TAOK2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TAOK2 About    
    See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2Cytoplasmic microtubules
    Cytoplasmic microtubules0.32
    3p38 MAPK signaling pathway (Pathway Interaction Database)
    p38 MAPK signaling pathway


    Find genes that share SuperPaths with TAOK2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for TAOK2
        MAPK signaling pathway
    p38 MAPK signaling pathway


    1 Kegg Pathway  (Kegg details for TAOK2):
        MAPK signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TAOK2
    Interactions:

        GeneGlobe Interaction Network for TAOK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    Selected Interacting proteins for TAOK2 (Q9UL543 ENSP000003100944) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000232575P074373, ENSP000004100714I2D: score=1 STRING: ENSP00000410071
    ENSG00000183311P074373I2D: score=1 
    ENSG00000224156P074373I2D: score=1 
    ENSG00000227739P074373I2D: score=1 
    ENSG00000229684P074373I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000186activation of MAPKK activity IDA10660600
    GO:0001558regulation of cell growth NAS10660600
    GO:0006468protein phosphorylation ----
    GO:0006612protein targeting to membrane NAS10660600
    GO:0006915apoptotic process NAS10660600

    Find genes that share ontologies with TAOK2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TAOK2

    3 HMDB Compounds for TAOK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    1 DrugBank Compound for TAOK2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Phosphonoserine-- --target--10592235

    1 Novoseek inferred chemical compound relationship for TAOK2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 39.7 1 11517310 (1)



    Find genes that share compounds with TAOK2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TAOK2 gene (3 alternative transcripts): 
    NM_001252043.1  NM_004783.3  NM_016151.3  

    Unigene Cluster for TAOK2:

    TAO kinase 2
    Hs.291623  [show with all ESTs]
    Unigene Representative Sequence: AF061943
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308893(uc002dvb.2 uc021tgf.1 uc002dva.2 uc010bzm.2)
    ENST00000543033 ENST00000279394(uc002dvc.2) ENST00000416441(uc002dvd.2)
    ENST00000566552 ENST00000570844
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    Additional mRNA sequence: 

    AB020688.1 AF061943.1 AF263313.1 AK291473.1 AK304446.1 AL137701.1 AY358942.1 BC015204.1 
    BC031825.2 BC051798.1 BC054495.1 BC136653.1 BC136655.1 BC142663.1 BC144344.1 BC151221.1 
    BC152413.1 

    12 DOTS entries:

    DT.95362553  DT.100754217  DT.100754216  DT.92049109  DT.95171410  DT.95171407  DT.100754213  DT.100754214 
    DT.100754215  DT.91831027  DT.95353472  DT.120696682 

    Selected AceView cDNA sequences (see all 158):

    AL137701 CA951161 BM801657 CD671176 BC051798 CA942054 AI637830 BC031825 
    CA952874 AI199772 BC054495 BM987557 AY358942 CB049752 AI393849 NM_004783 
    BX281468 AF263313 NM_016151 BQ940691 AK057589 CO246565 CB155719 BU956237 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TAOK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCCAGGGG
    TAOK2 Expression
    About this image

    TAOK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TAOK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.291623

    UniProtKB/Swiss-Prot: TAOK2_HUMAN, Q9UL54
    Tissue specificity: Ubiquitously expressed, with a higher level of expression in testis and brain

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAOK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TAOK2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Taok21 , 5 TAO kinase 21, 5 90.1(n)1
    98.19(a)1
      7 (69.25 cM)5
    3819211  NM_001163774.11  NP_001157246.11 
     1268656785 
    lizard
    (Anolis carolinensis)
    Reptilia TAOK26
    TAO kinase 2
    67(a)
    1 ↔ 1
    GL343279.1(140550-161486)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia taok21 TAO kinase 2 75.25(n)
    82.9(a)
      780186  NM_001079261.1  NP_001072729.1 
    zebrafish
    (Danio rerio)
    Actinopterygii taok2b1 TAO kinase 2b 72.65(n)
    79.03(a)
      100151551  XM_005156005.1  XP_005156062.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tao6
    Tao
    39(a)
    1 → many
    X(19464418-19473841)
    worm
    (Caenorhabditis elegans)
    Secernentea kin-186
    Protein KIN-18, isoform a (kin-18) mRNA, complete ...
    33(a)
    1 → many
    III(6118632-6124067) WBGene00002201


    ENSEMBL Gene Tree for TAOK2 (if available)
    TreeFam Gene Tree for TAOK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TAOK2 gene
    MAP4K52  TAOK32  NRK2  TNIK2  MAP4K22  MAP4K12  MAP4K32  MAP4K42  
    STK102  TAOK12  MINK12  SLK2  
    Selected SIMAP similar genes for TAOK2 using alignment to 4 protein entries:     TAOK2_HUMAN (see all proteins) (see all similar genes):
    TAOK3    TAOK1    STK24    DKFZp686J1430    MST4    DKFZp564L2416
    MST094    PAK4    STK11    STK3    MAP3K2    STK25
    MAP2K5    MYO3A    STK4    NEK7    MARK4    NEK6

    Find genes that share paralogs with TAOK2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TAOK2 (see all 518)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1919932661,2
    --30882662(+) CCTTCC/GTGACA 3 -- us2k10--------
    rs1379044241,2
    --30883012(+) TCTAAC/TTGATG 3 -- us2k10--------
    rs1826119791,2
    --30883058(+) AACTTG/TACATG 3 -- us2k10--------
    rs1869679681,2
    --30883114(+) GATTCC/TGTTAA 3 -- us2k10--------
    rs1423357051,2
    --30883162(+) AGTGGA/GTGGGG 3 -- us2k10--------
    rs780739551,2
    C,F--30883345(+) GGGAAA/GAGTGG 3 -- us2k12Minor allele frequency- G:0.04WA EA 238
    rs119011,2
    C,F,O,A,H--30883481(-) GTTGAG/CAGGGT 3 -- us2k120Minor allele frequency- C:0.38MN NS EA NA CSA WA 1522
    rs1917537191,2
    --30883498(+) CTGGGA/CAAGGA 3 -- us2k10--------
    rs1505965861,2
    --30883567(+) TGCCCA/GTATTG 3 -- us2k10--------
    rs557436821,2
    C,F--30883784(+) CAGTGG/CCGTGT 3 -- us2k11Minor allele frequency- C:0.18NA 120

    HapMap Linkage Disequilibrium report for TAOK2 (29984962 - 30003582 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TAOK2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv997840CNV Deletion20482838
    dgv2668n71CNV Loss21882294
    nsv905717CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TAOK2
    DNA2.0 Custom Variant and Variant Library Synthesis for TAOK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613199    OMIM disorders: --


    Find genes that share disorders with TAOK2           About GenesLikeMe

    Genetic Association Database (GAD): TAOK2
    Human Genome Epidemiology (HuGE) Navigator: TAOK2 (1 document)

    Export disorders for TAOK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TAOK2 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with TAOK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
    2. The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability. (PubMed id 12639963)1, 2, 9 Mitsopoulos C.... Morris J.D. (J. Biol. Chem. 2003)
    3. PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the JNK MAPK pathway and regulates actin cytoskeletal organisation. (PubMed id 10660600)1, 2, 9 Moore T.M....Morris J.D.H. (J. Biol. Chem. 2000)
    4. Association and mutation analyses of 16p11.2 autism candidate genes. (PubMed id 19242545)1, 4 Kumar R.A....Christian S.L. (PLoS ONE 2009)
    5. Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK-and caspase-dependent nuclear localization is a requirement for membrane blebbing. (PubMed id 17158878)1, 2 Zihni C....Morris J.D. (J. Biol. Chem. 2007)
    6. TAO kinases mediate activation of p38 in response to DNA damage. (PubMed id 17396146)1, 2 Raman M.... Cobb M.H. (EMBO J. 2007)
    7. Osmotic stress activates the TAK1-JNK pathway while blocking TAK1- mediated NF-kappaB activation: TAO2 regulates TAK1 pathways. (PubMed id 16893890)1, 2 Huangfu W.C.... Ninomiya-Tsuji J. (J. Biol. Chem. 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38. (PubMed id 13679851)1, 2 Yustein J.T....Kung H.-J. (Oncogene 2003)
    10. TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors. (PubMed id 12665513)1, 2 Chen Z.... Cobb M.H. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9344 HGNC: 16835 AceView: TAO1 Ensembl:ENSG00000149930 euGenes: HUgn9344
    ECgene: TAOK2 Kegg: 9344 H-InvDB: TAOK2

    (According to HUGE)
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    HUGE: KIAA0881

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TAOK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TAOK2 gene:
    Search GeneIP for patents involving TAOK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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