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TAOK1 Gene

protein-coding   GIFtS: 57

GC17P024742
TAO kinase 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
EC 2.7.11.1 3
FLJ14314 1, 2
KIAA1361 1, 2, 3
MAP3K16 1, 2, 3
MARKK 1, 2
PSK2 1, 2
TAO1 1, 2
hKFC-B 3
Descriptions
Kinase from chicken homolog B 3
STE20-like kinase 2
STE20-like kinase PSK2 3
TAO kinase 1 2
Thousand and one amino acid protein 1 3
microtubule affinity regulating kinase kinase 2
serine/threonine kinase TAO1 2
serine/threonine protein kinase TAO1 homolog 2
External Ids
HGNC: 292591
Entrez Gene: 575512
UniProtKB: Q7L7X33
Ensembl: ENSG000001605517
Search outside databases for aliases for TAOK1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: TAOK1_HUMAN, Q7L7X3
Function: Phosphorylates MKK3 (By similarity). Activates the p38 MAP kinase pathway through the
specific activation of the upstream MKK3 kinase

Gene Wiki entry for TAOK1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the TAOK1 gene  

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

TAOK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P024742:     (about GC identifiers)

Start:
24,742,069 bp from pter
End:
24,895,628 bp from pter
Size:
153,560 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000017.9  NT_010799.14  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TAOK1_HUMAN, Q7L7X3 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase TAO1  
Size: 1001 amino acids; 116070 Da
Subunit: Self-associates. Interacts with MKK3 (By similarity)
Subcellular location: Cytoplasm
Secondary accessions: Q96L75 Q9H2K7 Q9H7S5 Q9P2I6
Alternative splicing: 2 isoforms:  Q7L7X3-1   Q7L7X3-2   

Post-translational modifications:

  • Autophosphorylated (By similarity)1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_065842.1  

    ENSEMBL proteins: 
    ENSP00000261716 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Millipore Purified and/or Recombinant TAOK1 Protein
    Sigma-Aldrich Proteins for TAOK1  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (TAOK1)
    Human Recombinant Proteins from Abnova (TAOK1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    About this table

    Antibodies for TAOK1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for TAOK1
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (TAOK1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (TAOK1)
    Novus Biologicals Antibodies for TAOK1

    Assays for TAOK1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser_thr_pkinase
     IPR017442 Se/Thr_pkinase-rel
     IPR008271 Ser_thr_pkin_AS
     IPR000719 Prot_kinase_core


       GeneDecks  TAOK1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q7L7X3

    ProtoNet protein and cluster: Q7L7X3

    UniProtKB/Swiss-Prot: TAOK1_HUMAN, Q7L7X3
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20
    subfamily
    Similarity: Contains 1 protein kinase domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (TAOK1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (TAOK1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_290796

                  Applied Biosystems Silencer® siRNAs for TAOK1

                  Sigma-Aldrich siRNA and siRNA Panels for TAOK1  
                         Sigma-Aldrich shRNA Panels and shRNA for TAOK1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_020791
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_020791
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_020791 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_020791

    UniProtKB/Swiss-Prot: TAOK1_HUMAN, Q7L7X3
    Function: Phosphorylates MKK3 (By similarity). Activates the p38 MAP kinase pathway through the
    specific activation of the upstream MKK3 kinase
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme Number (IUBMB): EC 2.7.11.1 

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0004674 protein serine/threonine kinase activity NAS14517247
    GO:0005524 ATP binding NAS14517247
    GO:0016740 transferase activity NAS14517247
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Millipore Pathway for TAOK1
     Cytoplasmic microtubules

       GeneDecks  TAOK1 for the pathways selected above  
    About GeneDecksing

    1 Kegg Pathway  (Kegg details for TAOK1):
     hsa04010 MAPK signaling pathway

       GeneDecks  TAOK1 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  TAOK1 


    5/84 Interacting proteins for TAOK1 (ENSP000002617163) via UniProtKB, MINT, and/or STRING (see all 84 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BUB1BENSP000002875983STRING (score=.973)
    MAP2K3ENSP000003191393STRING (score=.963)
    MAD1L1ENSP000002658543STRING (score=.962)
    UGP2ENSP000003387033STRING (score=.925)
    MAP2K6ENSP000003519973STRING (score=.905)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468 protein amino acid phosphorylation NAS14517247
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for TAOK1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (TAOK1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (TAOK1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_290796

                  Sigma-Aldrich siRNA and siRNA Panels for TAOK1  
                         Sigma-Aldrich shRNA Panels and shRNA for TAOK1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_020791  

    REFSEQ mRNAs for TAOK1 gene: 

    NM_020791.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_020791  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_020791
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_020791
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_020791 

    Additional cDNA sequence: 

    AB037782.1 AF263312.1 AY049015.1 BC032793.1 BC133039.1 BC144067.1 

    7 DOTS entries:

    DT.118228  DT.111869  DT.100759038  DT.75158002  DT.91898034  DT.97800864  DT.97818284 

    24/82 AceView cDNA sequences (see all 82 ):

    CA397311 AB037782 BE551394 BM802274 BE551345 AA426563 CA391905 CA950355 
    AL707021 CB160228 BI715239 CB159985 NM_020791 AA234623 CA950530 CA950298 
    CD675669 AI382292 BQ021858 BX487646 AA903832 M86125 BV194538 BQ374016 

    highest scoring ESTs for TAOK1:

    AA426563 W84433 AA193562 AA426562 AA503021 AA812069 AF263312 AI003991 AI333642 AI382292 

    Unigene Cluster for TAOK1:

    TAO kinase 1
    Hs.631758  [show with all ESTs]
    Unigene Representative Sequence: NM_020791


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TAOK1

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:                          -           -                                   -                                                                                 
    SP2:        -           -                 -                                                                                                                     
    SP3:                                                                                                                                                            
    SP4:                    -                                                                                                                                       

    ExUns: 22
    SP1:      
    SP2:      
    SP3:      
    SP4:      

    About this scheme

    ECgene alternative splicing isoforms for TAOK1

    1 Ensembl transcript including schematic representation:
    ENST00000261716  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    TAOK1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for TAOK1

    1 / 2 / 3

    7 probe-sets matching TAOK1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    79167_at2, 3 U95-D 1 1.00 1.00 0.75 1.59 AA426563 1.00 1.00 1.00 1

    75098_at2, 3 U95-E 1 0.94 1.00 0.57 0.43 AA903832 0.60 1.00 0.82 1

    58253_at2, 3 U95-B 1 0.69 1.00 0.28 0.19 W84433 1.00 1.00 1.00 1

    227454_at2, 3 U133-B 1 1.00 1.00 -- -- AB037782 0.80 0.88 0.84 1

    216310_at2, 3 U133-A 1 1.00 1.00 -- -- AK024376 0.40 1.00 0.76 1

    227454_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    216310_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  TAOK1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TGCAGGTCCT

    SOURCE GeneReport for Unigene cluster: Hs.631758

    UniProtKB/Swiss-Prot: TAOK1_HUMAN, Q7L7X3
    Tissue specificity: Highly expressed in the testis, and to a lower extent also expressed in brain,
    placenta, colon and skeletal muscle

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for TAOK1 gene from 5/13 species (see all 13 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    TAOK11   -- TAO kinase 1 95.23(n)
    99.2(a)
    480632  XM_863229.1  XP_868322.1 
    chimpanzee
    (Pan troglodytes)
    TAOK11   -- TAO kinase 1 99.83(n)
    100(a)
    454548  XM_001138940.1  XP_001138940.1 
    cow
    (Bos taurus)
    TAOK11   -- TAO kinase 1 95.24(n)
    99.7(a)
    536532  XM_616664.3  XP_616664.3 
    rat
    (Rattus norvegicus)
    Taok11   -- TAO kinase 1 93.54(n)
    98.9(a)
    286993  NM_173327.1  NP_775449.1 
    mouse
    (Mus musculus)
    Taok11, 5 115
    TAO kinase 11, 5 93.27(n)1
    99.4(a)1
    2169651  NM_144825.21  NP_659074.21 
     AA4745015  AA7944565  (see all 43)
    About this table        Species with no ortholog for TAOK1

    ENSEMBL Gene Tree for TAOK1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for TAOK1 gene
    TAOK22  TAOK32  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/800 NCBI SNPs in TAOK1 are shown (see all 800 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 125)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 17 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs177666751,2
    C,F,H24895151(+) TGCCCA/GAGACC 1 -- ut31 ese315Minor allele frequency- G:0.06NA EU EA WA 1396
    rs341510571,2
    C,F24893723(+) TGTTGG/ACTTTG 1 T/A mis14Minor allele frequency- A:0.01EU EA WA 420
    rs5087061,2
    A,C,F,H24859264(+) GCTGCC/TATGGA 1 A/A syn1 ese38Minor allele frequency- G:0.02EA NA EU WA 636
    rs5075771,2
    C,F,H24894094(+) CGGACG/AGAGCA 1 T/T syn1 ese35Minor allele frequency- A:0.23MN EU EA WA 564
    rs5764261,2
    A,C,F,H,O24874328(+) TTTTAA/GAACCC 1 -- int17Minor allele frequency- G:0.21EU EA WA NA 554
    rs47955121,2
    A,C,F,H24812630(+) GGCCAG/ACAAAC 1 -- int17Minor allele frequency- A:0.40EU EA WA NA 558
    rs72086751,2
    A,C,F,H24761274(+) TTgctA/Gtgtga 1 -- int14Minor allele frequency- G:0.18EU EA WA 416
    rs72083631,2
    A,C,F,H24757534(+) GTATTT/ATATAC 1 -- int14Minor allele frequency- A:0.34EU EA WA 416
    rs47955101,2
    A,C,F,H24802960(+) AGAGCA/GCGAGA 1 -- int14Minor allele frequency- G:0.18EU EA WA 420
    rs99002801,2
    A,C,F,H24793724(+) ACAGTA/GTTGAA 1 -- int17Minor allele frequency- G:0.24EU EA WA NA 558
    About this table

    HapMap Linkage Disequilibrium images for TAOK1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 610266

    Human Genome Epidemiology Navigator: TAOK1 (1 document)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/35 PubMed articles for TAOK1 gene (see all 35 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 57551 HGNC: 29259 AceView: KIAA1361 Ensembl:ENSG00000160551 euGenes: HUgn57551
    ECgene: TAOK1 H-InvDB: TAOK1
    (According to HUGE)
    About This Section

    HUGE: KIAA1361
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for TAOK1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for TAOK1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for TAOK1 Antibodies for TAOK1
     Explore super-pooled esiRNAs Proteins for TAOK1
     Lentivirus-delivered shRNAs for TAOK1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Search OriGene for TAOK1
     Search Tocris compounds for TAOK1




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for TAOK1

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