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Aliases & Descriptions for TAOK1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 2.7.11.1 3 | | FLJ14314 1, 2 | | KIAA1361 1, 2, 3 | | MAP3K16 1, 2, 3 | | MARKK 1, 2 | | PSK2 1, 2 | | TAO1 1, 2 | | hKFC-B 3 |
| | | Descriptions |
|---|
| Kinase from chicken homolog B 3 | | STE20-like kinase 2 | | STE20-like kinase PSK2 3 | | TAO kinase 1 2 | | Thousand and one amino acid protein 1 3 | | microtubule affinity regulating kinase kinase 2 | | serine/threonine kinase TAO1 2 | | serine/threonine protein kinase TAO1 homolog 2 |
|
| | Search outside databases for aliases for TAOK1 gene |
Summaries for TAOK1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: TAOK1_HUMAN, Q7L7X3Function: Phosphorylates MKK3 (By similarity). Activates the p38 MAP kinase pathway through the specific activation of the upstream MKK3 kinaseGene Wiki entry for TAOK1 |
Genomic Location for TAOK1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the TAOK1 gene 
Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q11.2TAOK1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P024742:
(about GC identifiers)
Start:
|
24,742,069 bp from pter |
End:
|
24,895,628 bp from pter |
Size:
|
153,560 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000017.9 NT_010799.14
| Proteins for TAOK1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: TAOK1_HUMAN, Q7L7X3 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase TAO1 Size: 1001 amino acids; 116070 Da
Subunit: Self-associates. Interacts with MKK3 (By similarity)
Subcellular location: Cytoplasm
Secondary accessions: Q96L75 Q9H2K7 Q9H7S5 Q9P2I6Alternative splicing: 2 isoforms: Q7L7X3-1 Q7L7X3-2 Post-translational modifications:
Autophosphorylated (By similarity)1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_065842.1
ENSEMBL proteins: ENSP00000261716
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- | About this table
Antibodies for TAOK1: Assays for TAOK1: | Protein
Domains/ Families for TAOK1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q7L7X3
ProtoNet protein and cluster: Q7L7X3 UniProtKB/Swiss-Prot: TAOK1_HUMAN, Q7L7X3Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamilySimilarity: Contains 1 protein kinase domain | Gene Function for TAOK1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_290796
Applied Biosystems Silencer® siRNAs for TAOK1
Sigma-Aldrich siRNA and siRNA Panels for TAOK1  Sigma-Aldrich shRNA Panels and shRNA for TAOK1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_020791                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_020791                                  untagged cDNA clones in CMV expression vector (see all 4): NM_020791 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_020791
UniProtKB/Swiss-Prot: TAOK1_HUMAN, Q7L7X3Function: Phosphorylates MKK3 (By similarity). Activates the p38 MAP kinase pathway through the specific activation of the upstream MKK3 kinaseCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Number (IUBMB): EC 2.7.11.1 4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for TAOK1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for TAOK1 
5/84 Interacting proteins for TAOK1 (ENSP000002617163) via UniProtKB, MINT, and/or STRING (see all 84
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006468 | protein amino acid phosphorylation |
NAS | 14517247 | About this table
|
Drugs & Compounds for TAOK1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for TAOK1
|
Transcripts for TAOK1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_290796
Sigma-Aldrich siRNA and siRNA Panels for TAOK1  Sigma-Aldrich shRNA Panels and shRNA for TAOK1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_020791 REFSEQ mRNAs for TAOK1 gene: NM_020791.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_020791               OriGene GFP tagged cDNA clone in CMV expression vector: NM_020791                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_020791                                  untagged cDNA clones in CMV expression vector (see all 4): NM_020791  Additional cDNA sequence: AB037782.1 AF263312.1 AY049015.1 BC032793.1 BC133039.1 BC144067.1 7 DOTS entries: DT.118228 DT.111869 DT.100759038 DT.75158002 DT.91898034 DT.97800864 DT.97818284 24/82 AceView cDNA sequences (see all 82
):CA397311 AB037782 BE551394 BM802274 BE551345 AA426563 CA391905 CA950355 AL707021 CB160228 BI715239 CB159985 NM_020791 AA234623 CA950530 CA950298 CD675669 AI382292 BQ021858 BX487646 AA903832 M86125 BV194538 BQ374016
highest scoring ESTs for TAOK1:AA426563 W84433 AA193562 AA426562 AA503021 AA812069 AF263312 AI003991 AI333642 AI382292 Unigene Cluster for TAOK1: TAO kinase 1 Hs.631758 [show with all ESTs]Unigene Representative Sequence: NM_020791
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for TAOK1
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | |
| SP1: | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | - |   | |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for TAOK1
1 Ensembl transcript including schematic representation: ENST00000261716
|
Expression for TAOK1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| TAOK1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for TAOK1
1 / 2 / 3 7 probe-sets matching TAOK1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGCAGGTCCT
SOURCE GeneReport for Unigene cluster: Hs.631758 UniProtKB/Swiss-Prot: TAOK1_HUMAN, Q7L7X3Tissue specificity: Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon and skeletal muscle |
Orthologs for TAOK1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TAOK1 gene from 5/13 species (see all 13
)
About this table Species with no ortholog for TAOK1
ENSEMBL Gene Tree for TAOK1 | Paralogs for TAOK1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for TAOK1 gene
- TAOK22 TAOK32
|
SNPs/Variants for TAOK1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for TAOK1 (up to first 250kb)
|
Disorders & Mutations for TAOK1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 610266
Human Genome Epidemiology Navigator: TAOK1 (1 document)
|
Medical News for TAOK1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for TAOK1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/35 PubMed articles for TAOK1 gene (see all 35
):- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)2, 3, 4 Nagase T....Ohara O. (2000)
- MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1. (PubMed id 14517247)1, 2, 3 Timm T....Mandelkow E.M. (2003)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)3, 4 Beausoleil S.A.... Gygi S.P. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)3, 4 Beausoleil S.A....Gygi S.P. (2004)
- Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38. (PubMed id 13679851)3, 4 Yustein J.T....Kung H.-J. (2003)
- Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades. (PubMed id 9786855)3, 4 Hutchison M....Cobb M.H. (1998)
- Human TAO kinase 1 induces apoptosis in SH-SY5Y cells. (PubMed id 17900936)1, 3 Wu M.F. and Wang S.G. (2008)
- A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling. (PubMed id 17417629)1, 3 Draviam V.M....Elledge S.J. (2007)
|
Search for TAOK1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TAOK1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing TAOK1
(According to HUGE)
About This Section
| |
Specialized Databases showing TAOK1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for TAOK1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for TAOK1:

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Incremental update: 13 Oct 2009
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