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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAOK1 Gene

protein-coding   GIFtS: 63
GCID: GC17P027717

TAO Kinase 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TAO Kinase 11 2     MARK Kinase2 3
MARKK2 3 5     EC 2.7.11.13 8
PSK22 3 5     TAO12 5
Kinase From Chicken Homolog B2 3     KFC-B2
Prostate-Derived STE20-Like Kinase 22 3     Microtubule Affinity Regulating Kinase Kinase2
Prostate-Derived Sterile 20-Like Kinase 22 3     Serine/Threonine Protein Kinase TAO1 Homolog2
Thousand And One Amino Acid Protein Kinase 12 3     Serine/Threonine-Protein Kinase TAO12
MAP3K162 3     STE20-Like Kinase PSK22
PSK-22 3     Thousand And One Amino Acid Protein 12
hKFC-B2 3     KIAA13613
hTAOK12 3     EC 2.7.118

External Ids:    HGNC: 292591   Entrez Gene: 575512   Ensembl: ENSG000001605517   OMIM: 6102665   UniProtKB: Q7L7X33   

Export aliases for TAOK1 gene to outside databases

Previous GC identifers: GC17P024742 GC17P023926


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TAOK1 Gene: 
TAOK1 (TAO kinase 1) is a protein-coding gene. Diseases associated with TAOK1 include prostatitis, and hypospadias, and among its related super-pathways are MAPK signaling pathway and Mitotic Anaphase. GO annotations related to this gene include protein serine/threonine kinase activity and kinase activity. An important paralog of this gene is TAOK2.

UniProtKB/Swiss-Prot: TAOK1_HUMAN, Q7L7X3
Function: Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK
cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2.
Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent
activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to
p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the
p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a
regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase
activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of
apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic
bodies formation via activation of the MAPK8/JNK cascade

Gene Wiki entry for TAOK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010799.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAOK1 gene promoter:
         AhR   AP-1   RREB-1   Bach2   ATF-2   Tal-1beta   COMP1   SEF-1 (1)   c-Jun   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAOK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TAOK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAOK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

TAOK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAOK1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P027717:  view genomic region     (about GC identifiers)

Start:
27,717,482 bp from pter      End:
27,878,922 bp from pter
Size:
161,441 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TAOK1_HUMAN, Q7L7X3 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase TAO1  
Size: 1001 amino acids; 116070 Da
Subunit: Self-associates. Interacts with MAP2K3 (By similarity). Interacts with SPRED1 and TESK1. Interacts with
MAP3K7
Subcellular location: Cytoplasm
Caution: Was initially thought to play a role in the spindle checkpoint (PubMed:17417629). However, it was later
shown that it is not the case and that phenotypes initially observed are the cause of the siRNA used that has an
off-target effect resulting in MAD2L1 inhibition (PubMed:19904549 and PubMed:20162290)
Sequence caution: Sequence=BAA92599.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A2RUT8 B7ZLV6 Q96L75 Q9H2K7 Q9H7S5 Q9P2I6
Alternative splicing: 3 isoforms:  Q7L7X3-1   Q7L7X3-2   Q7L7X3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TAOK1: NX_Q7L7X3

Explore proteomics data for TAOK1 at MOPED 

Post-translational modifications:

  • UniProtKB: Proteolytically processed by caspase-3 (CASP3)
  • UniProtKB: Autophosphorylated (By similarity). Phosphorylated by ATM in response to DNA damage. Phosphorylated by LRRK2
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7L7X3

  • 4/46 DME Specific Peptides for TAOK1 (Q7L7X3) (see all 46)
     LQHQTEL  KAGNILL  EYKGCYL  ERELRRK 

    TAOK1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TAOK1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_065842.1  NP_079418.1  

    ENSEMBL proteins: 
     ENSP00000464562   ENSP00000261716   ENSP00000438819  
    Reactome Protein details: Q7L7X3
    Human Recombinant Protein Products for TAOK1: 
    EMD Millipore Purified and/or Recombinant TAOK1 Protein
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TAOK1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TAOK1
    GenScript Custom Purified and Recombinant Proteins Services for TAOK1
    Novus Biologicals TAOK1 Protein
    Novus Biologicals TAOK1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TAOK1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    TAOK1 for ontologies           About GeneDecksing



    TAOK1 Antibody Products: 
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    Cloud-Clone Corp. Antibodies for TAOK1 
    ThermoFisher Antibodies for TAOK1
    LSBio Antibodies in human, mouse, rat for TAOK1 

    Assay Products for TAOK1: 
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    Cloud-Clone Corp. ELISAs for TAOK1 
    Cloud-Clone Corp. CLIAs for TAOK1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: TAO kinase 1 
    TAO subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q7L7X3

    ProtoNet protein and cluster: Q7L7X3

    UniProtKB/Swiss-Prot: TAOK1_HUMAN, Q7L7X3
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 protein kinase domain


    TAOK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAOK1_HUMAN, Q7L7X3
    Function: Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK
    cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2.
    Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent
    activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to
    p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the
    p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a
    regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase
    activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of
    apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic
    bodies formation via activation of the MAPK8/JNK cascade
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Serine/threonine-protein kinase activity is inhibited by SPRED1
    Induction: In response to DNA damage

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0004672protein kinase activity NAS14517247
    GO:0004674protein serine/threonine kinase activity NAS14517247
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding NAS14517247
         
    TAOK1 for ontologies           About GeneDecksing


    Phenotypes:
         6 GenomeRNAi human phenotypes for TAOK1:
     Decreased Tat-dependent transc  Decreased focal adhesion (FA)   Decreased p24 protein expressi  Decreased substrate adherent c 
     Reduced beta-catenin activity   Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TAOK1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TAOK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TAOK1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TAOK1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TAOK1
    8/294 QIAGEN miScript miRNA Assays for microRNAs that regulate TAOK1 (see all 294):
    hsa-miR-194* hsa-miR-579 hsa-miR-193a-3p hsa-miR-520f hsa-miR-605 hsa-miR-3916 hsa-miR-1273d hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidTAOK1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TAOK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAOK1

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of TAOK1

    Clone
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    OriGene ORF clones in mouse, rat for TAOK1
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    GenScript: all cDNA clones in your preferred vector (see all 2): TAOK1 (NM_020791)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAOK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAOK1
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                         Customized lentivirus expression plasmids for stable overexpression of TAOK1 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAOK1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TAOK1 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Separation of Sister Chromatids0.94
    Mitotic M-M/G1 phases0.88
    Mitotic Metaphase and Anaphase0.94
    3Resolution of Sister Chromatid Cohesion
    Resolution of Sister Chromatid Cohesion0.93
    Mitotic Prometaphase0.93
    4Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    5Cytoskeleton remodeling Neurofilaments
    Cytoplasmic microtubules0.32

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TAOK1
        Cytoplasmic microtubules


    3 BioSystems Pathways for TAOK1
        MAPK signaling pathway
    p38 MAPK signaling pathway
    Regulation of Microtubule Cytoskeleton

    5/9        Reactome Pathways for TAOK1 (see all 9)
        Mitotic Metaphase and Anaphase
    Mitotic Prometaphase
    Resolution of Sister Chromatid Cohesion
    Mitotic Anaphase
    Cell Cycle


    1         Kegg Pathway  (Kegg details for TAOK1):
        MAPK signaling pathway


    TAOK1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TAOK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/661 Interacting proteins for TAOK1 (Q7L7X32, 3 ENSP000002617164) via UniProtKB, MINT, STRING, and/or I2D (see all 661)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WT1P195442, 3, ENSP000003313274MINT-8277152 I2D: score=2 STRING: ENSP00000331327
    C8orf33Q9H7E92, 3MINT-8250534 I2D: score=2 
    CSNK1EP496742, 3MINT-8252824 I2D: score=2 
    DYNC1I1O145762, 3MINT-8254941 I2D: score=2 
    DAXXQ9UER73I2D: score=2 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0006281DNA repair IEA--
    GO:0006468protein phosphorylation NAS14517247
    GO:0006974response to DNA damage stimulus IDA17396146
    GO:0031572G2 DNA damage checkpoint IMP17396146

    TAOK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TAOK1

    2 HMDB Compounds for TAOK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--

    Search CenterWatch for drugs/clinical trials and news about TAOK1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TAOK1 gene (2 alternative transcripts): 
    NM_020791.2  NM_025142.1  

    Unigene Cluster for TAOK1:

    TAO kinase 1
    Hs.597434  [show with all ESTs]
    Unigene Representative Sequence: NM_020791
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000583121 ENST00000261716(uc002hdz.2 uc010wbe.2) ENST00000587277
    ENST00000536202 ENST00000577583(uc002heb.1) ENST00000578653
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TAOK1
    8/294 QIAGEN miScript miRNA Assays for microRNAs that regulate TAOK1 (see all 294):
    hsa-miR-194* hsa-miR-579 hsa-miR-193a-3p hsa-miR-520f hsa-miR-605 hsa-miR-3916 hsa-miR-1273d hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidTAOK1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAOK1
    Clone
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    OriGene clones in human, mouse for TAOK1 (see all 6)
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAOK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAOK1
    Sirion Biotech Customized lentivirus for stable overexpression of TAOK1 
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAOK1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAOK1

    Additional mRNA sequence: 

    AB037782.1 AF263312.1 AK025902.1 AL110163.1 AL833649.1 AY049015.1 BC024166.1 BC032793.1 
    BC037535.2 BC037740.2 BC047652.1 BC051737.1 BC062764.1 BC133039.1 BC144067.1 

    9 DOTS entries:

    DT.118228  DT.111869  DT.92436795  DT.100759038  DT.120919270  DT.75158002  DT.91898034  DT.97800864 
    DT.97818284 

    24/82 AceView cDNA sequences (see all 82):

    CD675669 BM802274 CB159985 CA391905 AA426563 BI715239 AA234623 CA397311 
    CA950355 AB037782 CB160228 NM_020791 CA950298 BE551394 CA950530 BE551345 
    AL707021 BQ024994 AU158580 BG169535 AI382832 M86125 BF082277 BX109394 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TAOK1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:                          -           -                                   -                                                                                 
    SP2:        -           -                 -                                                                                                                     
    SP3:                                                                                                                                                            
    SP4:                    -                                                                                                                                       

    ExUns: 22
    SP1:      
    SP2:      
    SP3:      
    SP4:      


    ECgene alternative splicing isoforms for TAOK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TAOK1 expression in normal human tissues (normalized intensities)      TAOK1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGAAATTTT
    TAOK1 Expression
    About this image


    TAOK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             pre Conventional Dendritic Cells Peripheral Blood
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             retinal progenitor cell e12.5   
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Ovary (Reproductive System)
             oocyte   

    See TAOK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TAOK1

    SOURCE GeneReport for Unigene cluster: Hs.597434

    UniProtKB/Swiss-Prot: TAOK1_HUMAN, Q7L7X3
    Tissue specificity: Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon
    and skeletal muscle

        SABiosciences Custom PCR Arrays for TAOK1
    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TAOK1 gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Taok11 , 5 TAO kinase 11, 5 93.27(n)1
    99.4(a)1
      11 (46.64 cM)5
    2169651  NM_144825.21  NP_659074.21 
     775291625 
    chicken
    (Gallus gallus)
    Aves TAOK11 TAO kinase 1 87.1(n)
    98.3(a)
      417583  XM_415829.3  XP_415829.3 
    lizard
    (Anolis carolinensis)
    Reptilia TAOK16
    Uncharacterized protein
    95(a)
    1 ↔ 1
    GL343462.1(300869-333405)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC529432 similar to serine/threonine protein kinase TAO1 82.69(n)    BC043764.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000045761 serine/threonine-protein kinase TAO1-like 73.3(n)
    85.3(a)
      100004576  XM_001343802.3  XP_001343838.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tao-11 CG14217-PA 55.7(n)
    54.76(a)
      32948  NM_001201743.1  NP_001188672.1 
    worm
    (Caenorhabditis elegans)
    Secernentea kin-181 Protein KIN-18 49.46(n)
    41.19(a)
      175862  NM_001027596.1  NP_001022767.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SKM16
    CLA46
    Member of the PAK family of serine/threonine prote...
    Cdc42p-activated signal transducing kinase of the ...
    15(a)
    12(a)
    many ↔ many
    many ↔ many
    XV(104326-106293)
    XIV(68915-71443)


    ENSEMBL Gene Tree for TAOK1 (if available)
    TreeFam Gene Tree for TAOK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TAOK1 gene
    TAOK22  MAP4K52  TAOK32  NRK2  TNIK2  MAP4K22  MAP4K12  MAP4K32  
    MAP4K42  STK102  MINK12  SLK2  
    8 SIMAP similar genes for TAOK1 using alignment to 2 protein entries:     TAOK1_HUMAN (see all proteins):
    TAOK3    TAOK2    MST4    STK24    STK25    NEK6
    NEK7    STK4

    TAOK1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2918 SNPs in TAOK1 are shown (see all 2918)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1502032471,2
    C--27718250(+) TTTTCC/GTGAGG 2 -- int10--------
    rs1387181601,2
    --27718291(+) TTTCGA/GGGAAG 2 -- int10--------
    rs1179711131,2
    C,F--27718315(+) AGGGAG/AACTGG 2 -- int11Minor allele frequency- A:0.01NA 120
    rs747991811,2
    C,F--27718504(+) AAGCGT/GTTCTC 2 -- int11Minor allele frequency- G:0.05WA 118
    rs1919692741,2
    --27718582(+) CTTCAC/TACACA 2 -- int10--------
    rs1495432441,2
    C--27718652(+) GAAAAG/TGTTAC 2 -- int10--------
    rs1441240381,2
    --27718738(+) TATCTA/GTTCTG 2 -- int10--------
    rs1405743131,2
    --27718875(+) ATTCAA/GATAAA 2 -- int10--------
    rs1842298341,2
    --27718928(+) TATGAC/TTTTTG 2 -- int10--------
    rs1428167641,2
    --27718941(+) GTTCAG/TGAAGA 2 -- int10--------

    HapMap Linkage Disequilibrium report for TAOK1 (27717482 - 27878922 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for TAOK1 (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2335781CNV Deletion18987734
    esv2673792CNV Deletion23128226
    esv2715797CNV Deletion23290073
    esv2658989CNV Deletion23128226
    esv2474903CNV Deletion19546169
    nsv821292CNV Duplication20802225
    nsv819892CNV Loss19587683
    esv22895CNV Loss19812545
    nsv827940CNV Gain20364138
    nsv833409CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610266    OMIM disorders: --

    4 diseases for TAOK1:    About MalaCards
    prostatitis    hypospadias    choroiditis    neuronitis


    TAOK1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TAOK1
    Human Genome Epidemiology (HuGE) Navigator: TAOK1 (2 documents)

    Export disorders for TAOK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TAOK1 gene, integrated from 9 sources (see all 63):
    (articles sorted by number of sources associating them with TAOK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. Human TAO kinase 1 induces apoptosis in SH-SY5Y cells. (PubMed id 17900936)1, 2, 9 Wu M.F. and Wang S.G. (2008)
    3. MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1. (PubMed id 14517247)1, 3, 9 Timm T....Mandelkow E.M. (2003)
    4. A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling. (PubMed id 17417629)1, 2, 9 Draviam V.M....Elledge S.J. (2007)
    5. New gene functions in megakaryopoiesis and platelet fo rmation. (PubMed id 22139419)1, 4 Gieger C....Soranzo N. (2011)
    6. Re-evaluating the role of Tao1 in the spindle checkpo int. (PubMed id 20162290)1, 2 Westhorpe F.G....Taylor S.S. (2010)
    7. Re-examination of siRNA specificity questions role of PICH and Tao1 in the spindle checkpoint and identifies Mad2 as a sensitive tar get for small RNAs. (PubMed id 19904549)1, 2 HA1bner N.C....Nigg E.A. (2010)
    8. A genome-wide meta-analysis identifies 22 loci associ ated with eight hematological parameters in the HaemGen consortium. (PubMed id 19820697)1, 4 Soranzo N....Gieger C. (2009)
    9. A genome-wide association study identifies three loci associated with mean platelet volume. (PubMed id 19110211)1, 4 Meisinger C....DAPring A. (2009)
    10. TAO kinases mediate activation of p38 in response to DNA damage. (PubMed id 17396146)1, 2 Raman M....Cobb M.H. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57551 HGNC: 29259 AceView: KIAA1361 Ensembl:ENSG00000160551 euGenes: HUgn57551
    ECgene: TAOK1 Kegg: 57551 H-InvDB: TAOK1

    (According to HUGE)
    About This Section
    HUGE: KIAA1361

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TAOK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TAOK1 gene:
    Search GeneIP for patents involving TAOK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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