TAOK1 Gene
protein-coding GIFtS: 60
GCID: GC17P027717
|
|
TAO kinase 1
| |
Aliases
for TAOK1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TAO Kinase 11 2 | | HTAOK11 | | MARKK1 2 3 5 | | MARK Kinase2 3 | | PSK21 2 3 5 | | EC 2.7.11.13 8 | | MAP3K161 2 3 | | FLJ143141 | | TAO11 2 5 | | KFC-B2 | | KIAA13611 3 | | Microtubule Affinity Regulating Kinase Kinase2 | | Kinase From Chicken Homolog B2 3 | | Serine/Threonine Protein Kinase TAO1 Homolog2 | | Prostate-Derived STE20-Like Kinase 22 3 | | Serine/Threonine-Protein Kinase TAO12 | | Prostate-Derived Sterile 20-Like Kinase 22 3 | | STE20-Like Kinase PSK22 | | Thousand And One Amino Acid Protein Kinase 12 3 | | Thousand And One Amino Acid Protein 12 | | PSK-22 3 | | EC 2.7.118 | | HKFC-B1 | | |
Export aliases for TAOK1 gene to outside databasesPrevious GC identifers: GC17P024742 GC17P023926 |
Summaries
for TAOK1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TAOK1_HUMAN, Q7L7X3Function: Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPKcascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Actsas an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activationof the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In responseto DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activatedMAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeletonstability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequentphosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulatesapoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation viaactivation of the MAPK8/JNK cascade
Gene Wiki entry for TAOK1
|
Genomic Views
for TAOK1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010799.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TAOK1 gene promoter:
AhR AP-1 RREB-1 Bach2 ATF-2 Tal-1beta COMP1 SEF-1 (1) c-Jun ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TAOK1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAOK1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q11.2 Ensembl cytogenetic band: 17q11.2 HGNC cytogenetic band: 17q11.2TAOK1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P027717: view genomic region
(about GC identifiers)
Start:
|
27,717,482 bp from pter |
End:
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27,878,922 bp from pter |
Size:
|
161,441 bases |
Orientation:
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plus strand |
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Proteins
for TAOK1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TAOK1_HUMAN, Q7L7X3 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase TAO1 Size: 1001 amino acids; 116070 Da
Subunit: Self-associates. Interacts with MAP2K3 (By similarity). Interacts with SPRED1 and TESK1. Interacts with MAP3K7
Subcellular location: Cytoplasm
Caution: Was initially thought to play a role in the spindle checkpoint (PubMed:17417629). However, it was later shownthat it is not the case and that phenotypes initially observed are the cause of the siRNA used that has an off-targeteffect resulting in MAD2L1 inhibition (PubMed:19904549 and PubMed:20162290)
Sequence caution: Sequence=BAA92599.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A2RUT8 B7ZLV6 Q96L75 Q9H2K7 Q9H7S5 Q9P2I6Alternative splicing: 3 isoforms: Q7L7X3-1 Q7L7X3-2 Q7L7X3-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TAOK1: NX_Q7L7X3
Post-translational modifications:
Proteolytically processed by caspase-3 (CASP3)1
Autophosphorylated (By similarity). Phosphorylated by ATM in response to DNA damage. Phosphorylated by LRRK21
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7L7X3
4/46 DME Specific Peptides for TAOK1 (Q7L7X3) (see all 46)
TAOK1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_065842.1 NP_079418.1
ENSEMBL proteins: ENSP00000464562 ENSP00000261716 ENSP00000438819 Reactome Protein details: Q7L7X3
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
TAS | -- |
TAOK1 for ontologies About GeneDecksing
TAOK1 Antibody Products:
Assay Products for TAOK1: |
Protein
Domains /
Families
for TAOK1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TAOK1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7L7X3ProtoNet protein and cluster: Q7L7X3 UniProtKB/Swiss-Prot: TAOK1_HUMAN, Q7L7X3Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamilySimilarity: Contains 1 protein kinase domain |
Function
for TAOK1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TAOK1_HUMAN, Q7L7X3Function: Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPKcascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Actsas an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activationof the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In responseto DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activatedMAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeletonstability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequentphosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulatesapoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation viaactivation of the MAPK8/JNK cascadeCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Serine/threonine-protein kinase activity is inhibited by SPRED1Induction: In response to DNA damageEnzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAOK1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAOK1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TAOK1 (NM_020791) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAOK1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAOK1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAOK1 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
TAOK1 for ontologies About GeneDecksing
6 GenomeRNAi human phenotypes for TAOK1:
|
Pathways & Interactions
for TAOK1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | M Phase | | | 2 | Resolution of Sister Chromatid Cohesion | | | 3 | MAPK signaling pathway | | | 4 | Cell Cycle | | | 5 | p38 MAPK signaling pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for TAOK1
2  BioSystems Pathways for TAOK1
5/10 
Reactome Pathways for TAOK1 (see all 10)
1 
Kegg Pathway (Kegg details for TAOK1):
TAOK1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TAOK1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/629 Interacting proteins for TAOK1 (Q7L7X32, 3 ENSP000002617164) via UniProtKB, MINT, STRING, and/or I2D (see all 629)About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table
TAOK1 for ontologies About GeneDecksing
|
Drugs & Compounds
for TAOK1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TAOK1
2 HMDB Compounds for TAOK1 About this table
Search CenterWatch for drugs/clinical trials and news about TAOK1
|
Transcripts
for TAOK1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TAOK1 gene (2 alternative transcripts): NM_020791.2 NM_025142.1 Unigene Cluster for TAOK1: TAO kinase 1 Hs.597434 [show with all ESTs]Unigene Representative Sequence: NM_0207916 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000583121 ENST00000261716(uc002hdz.2 uc010wbe.2) ENST00000587277
ENST00000536202 ENST00000577583(uc002heb.1) ENST00000578653
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAOK1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAOK1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TAOK1 (NM_020791) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAOK1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAOK1 |
Additional cDNA sequence: AB037782.1 AF263312.1 AK025902.1 AL110163.1 AL833649.1 AY049015.1 BC024166.1 BC032793.1 BC037535.2 BC037740.2 BC047652.1 BC051737.1 BC062764.1 BC133039.1 BC144067.1 10 DOTS entries: DT.118228 DT.111869 DT.92436795 DT.100759038 DT.120919270 DT.120919297 DT.75158002 DT.91898034 DT.97800864 DT.97818284 24/82 AceView cDNA sequences (see all 82): CA950355 CA950530 CA391905 BI715239 AA426563 CA950298 NM_020791 CB159985 CA397311 AB037782 CD675669 BE551345 AA234623 CB160228 AL707021 BE551394 BM802274 BU532303 BG938679 CA395289 AY049015 BX487646 BG169535 BI092285
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for TAOK1 About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ |
|---|
|
| SP1: | | | | | | | | | - | | | | - | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 22 |
|---|
|
| SP1: | | | |
| SP2: | | | |
| SP3: | | | |
| SP4: | | |
ECgene alternative splicing isoforms for TAOK1
|
Expression
for TAOK1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TAOK1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGAAATTTT
About this image
See TAOK1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TAOK1
SOURCE GeneReport for Unigene cluster: Hs.597434
UniProtKB/Swiss-Prot: TAOK1_HUMAN, Q7L7X3Tissue specificity: Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon andskeletal muscle
SABiosciences Custom PCR Arrays for TAOK1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAOK1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TAOK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAOK1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAOK1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAOK1 |
Orthologs
for TAOK1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TAOK1 gene from 6/22 species (see all 22) About this table
ENSEMBL Gene Tree for TAOK1 (if available)
TreeFam Gene Tree for TAOK1 (if available) |
Paralogs
for TAOK1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TAOK1 gene
- TAOK22 MAP4K52 TAOK32 NRK2 TNIK2 MAP4K22 MAP4K12 MAP4K32
- MAP4K42 STK102 MINK12 SLK2
8 SIMAP similar genes for TAOK1 using alignment to 2 protein entries: TAOK1_HUMAN (see all proteins):TAOK3 TAOK2 MST4 STK24 STK25 NEK6
NEK7 STK4
TAOK1 for paralogs About GeneDecksing
|
Genomic Variants
for TAOK1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TAOK1 (27717482 - 27878922 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for TAOK1
3 CNVs: 102432 67170 58788
1 Indel: 45522 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAOK1 |
|
Disorders
/ Diseases
for TAOK1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TAOK1 for disorders About GeneDecksing
OMIM gene information: 610266
OMIM disorders: --
4  diseases for TAOK1: About MalaCardsprostatitis hypospadias choroiditis neuronitis
Human Genome Epidemiology (HuGE) Navigator: TAOK1 (2 documents)
Export disorders for TAOK1 gene to outside databases
|
Publications
for TAOK1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TAOK1 gene, integrated from 9 sources (see all 58):
(articles sorted by number of sources associating them with TAOK1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (2000)
- Human TAO kinase 1 induces apoptosis in SH-SY5Y cells. (PubMed id 17900936)1, 2, 9 Wu M.F. and Wang S.G. (2008)
- MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1. (PubMed id 14517247)1, 3, 9 Timm T....Mandelkow E.M. (2003)
- A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling. (PubMed id 17417629)1, 2, 9 Draviam V.M....Elledge S.J. (2007)
- Re-evaluating the role of Tao1 in the spindle checkpo int. (PubMed id 20162290)1, 2 Westhorpe F.G....Taylor S.S. (2010)
- Re-examination of siRNA specificity questions role of PICH and Tao1 in the spindle checkpoint and identifies Mad2 as a sensitive tar get for small RNAs. (PubMed id 19904549)1, 2 HA1bner N.C....Nigg E.A. (2010)
- TAO kinases mediate activation of p38 in response to DNA damage. (PubMed id 17396146)1, 2 Raman M....Cobb M.H. (2007)
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways. (PubMed id 16893890)1, 2 Huangfu W.C.... Ninomiya-Tsuji J. (2006)
- Prostate-derived sterile 20-like kinase 2 (PSK2) regulates apoptotic morphology via C-Jun N-terminal kinase and Rho kinase-1. (PubMed id 16407310)1, 2 Zihni C....Morris J.D. (2006)
|
External Searches for TAOK1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TAOK1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TAOK1 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing TAOK1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TAOK1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TAOK1 gene:
Search GeneIP for patents involving TAOK1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TAOK1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TAOK1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TAOK1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAOK1 | | | OriGene Protein Over-expression Lysate for TAOK1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for TAOK1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAOK1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAOK1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TAOK1 | | OriGene Custom Protein Services for TAOK1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TAOK1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAOK1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAOK1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAOK1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAOK1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAOK1 |
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| | | | Search Tocris compounds for TAOK1 |
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 | | | TAOK1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAOK1 |
|  |  |  | | | | ThermoFisher Antibodies for TAOK1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAOK1 |
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