Aliases for TAOK1 Gene
External Ids for TAOK1 Gene
Previous GeneCards Identifiers for TAOK1 Gene
GeneCards Summary for TAOK1 Gene
TAOK1 (TAO Kinase 1) is a Protein Coding gene. Diseases associated with TAOK1 include Chromosome 17Q11.2 Deletion Syndrome, 1.4-Mb. Among its related pathways are Cell Cycle, Mitotic and p38 MAPK signaling pathway (Pathway Interaction Database). GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TAOK3.
UniProtKB/Swiss-Prot for TAOK1 Gene
Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating Thr-208 of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade.