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TAOK1 Gene

protein-coding   GIFtS: 64
GCID: GC17P027717

TAO Kinase 1

  Search for TAOK1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TAO Kinase 11 2     MARK Kinase2 3
MARKK2 3 5     EC 2.7.11.13 8
PSK22 3 5     TAO12 5
Kinase From Chicken Homolog B2 3     KFC-B2
Prostate-Derived STE20-Like Kinase 22 3     Microtubule Affinity Regulating Kinase Kinase2
Prostate-Derived Sterile 20-Like Kinase 22 3     Serine/Threonine Protein Kinase TAO1 Homolog2
Thousand And One Amino Acid Protein Kinase 12 3     Serine/Threonine-Protein Kinase TAO12
MAP3K162 3     STE20-Like Kinase PSK22
PSK-22 3     Thousand And One Amino Acid Protein 12
hKFC-B2 3     KIAA13613
hTAOK12 3     EC 2.7.118

External Ids:    HGNC: 292591   Entrez Gene: 575512   Ensembl: ENSG000001605517   OMIM: 6102665   UniProtKB: Q7L7X33   

Export aliases for TAOK1 gene to outside databases

Previous GC identifers: GC17P024742 GC17P023926


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TAOK1 Gene:
TAOK1 (TAO kinase 1) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity and kinase activity. An important paralog of this gene is TAOK2.

UniProtKB/Swiss-Prot: TAOK1_HUMAN, Q7L7X3
Function: Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK
cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2.
Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent
activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to
p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the
p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a
regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase
activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of
apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic
bodies formation via activation of the MAPK8/JNK cascade

Gene Wiki entry for TAOK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TAOK1 gene promoter:
         AhR   AP-1   RREB-1   Bach2   ATF-2   Tal-1beta   COMP1   SEF-1 (1)   c-Jun   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAOK1 promoter sequence
   Search Chromatin IP Primers for TAOK1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAOK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

TAOK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAOK1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P027717:  view genomic region     (about GC identifiers)

Start:
27,717,482 bp from pter      End:
27,878,922 bp from pter
Size:
161,441 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TAOK1_HUMAN, Q7L7X3 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase TAO1  
Size: 1001 amino acids; 116070 Da
Subunit: Self-associates. Interacts with MAP2K3 (By similarity). Interacts with SPRED1 and TESK1. Interacts with
MAP3K7
Caution: Was initially thought to play a role in the spindle checkpoint (PubMed:17417629). However, it was later
shown that it is not the case and that phenotypes initially observed are the cause of the siRNA used that has an
off-target effect resulting in MAD2L1 inhibition (PubMed:19904549 and PubMed:20162290)
Sequence caution: Sequence=BAA92599.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A2RUT8 B7ZLV6 Q96L75 Q9H2K7 Q9H7S5 Q9P2I6
Alternative splicing: 3 isoforms:  Q7L7X3-1   Q7L7X3-2   Q7L7X3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TAOK1: NX_Q7L7X3

Explore proteomics data for TAOK1 at MOPED

Post-translational modifications: 

  • Proteolytically processed by caspase-3 (CASP3)1
  • Autophosphorylated (By similarity). Phosphorylated by ATM in response to DNA damage. Phosphorylated by LRRK21
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TAOK1 (Q7L7X3) (see all 46)
     LQHQTEL  KAGNILL  EYKGCYL  ERELRRK 


    See TAOK1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_065842.1  NP_079418.1  

    ENSEMBL proteins: 
     ENSP00000464562   ENSP00000261716   ENSP00000438819  
    Reactome Protein details: Q7L7X3

    TAOK1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant TAOK1 Protein
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    Novus Biologicals TAOK1 Protein
    Novus Biologicals TAOK1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TAOK1

     
    Search eBioscience for Proteins for TAOK1 

    TAOK1 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for TAOK1

    TAOK1 Assay Products:

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    Cloud-Clone Corp. ELISAs for TAOK1
    Cloud-Clone Corp. CLIAs for TAOK1
    Search eBioscience for ELISAs for TAOK1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: TAO kinase 1
    TAO subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q7L7X3

    ProtoNet protein and cluster: Q7L7X3

    UniProtKB/Swiss-Prot: TAOK1_HUMAN, Q7L7X3
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with TAOK1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAOK1_HUMAN, Q7L7X3
    Function: Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK
    cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2.
    Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent
    activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to
    p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the
    p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a
    regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase
    activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of
    apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic
    bodies formation via activation of the MAPK8/JNK cascade
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Serine/threonine-protein kinase activity is inhibited by SPRED1
    Induction: In response to DNA damage

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0004672protein kinase activity NAS14517247
    GO:0004674protein serine/threonine kinase activity NAS14517247
    GO:0004709MAP kinase kinase kinase activity IBA--
    GO:0004713protein tyrosine kinase activity ----
         
    Find genes that share ontologies with TAOK1           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for TAOK1:
     Decreased Tat-dependent transc  Decreased focal adhesion (FA)   Decreased p24 protein expressi  Decreased substrate adherent c 
     Reduced beta-catenin activity   Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TAOK1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TAOK1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TAOK1

    miRNA
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    miRTarBase miRNAs that target TAOK1:
    hsa-mir-142-3p (MIRT021639), hsa-mir-96-5p (MIRT027919), hsa-mir-30b-5p (MIRT023458), hsa-mir-425-5p (MIRT016671)

    Block miRNA regulation of human, mouse, rat TAOK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TAOK1 (see all 294):
    hsa-miR-194* hsa-miR-579 hsa-miR-193a-3p hsa-miR-520f hsa-miR-605 hsa-miR-3916 hsa-miR-1273d hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidTAOK1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TAOK1
    Predesigned siRNA for gene silencing in human, mouse, rat TAOK1

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): TAOK1 (NM_020791)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAOK1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAOK1

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    Browse ESI BIO Cell Lines and PureStem Progenitors for TAOK1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAOK1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TAOK1_HUMAN, Q7L7X3: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    cytoskeleton1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IBA--
    GO:0005829cytosol TAS--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with TAOK1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TAOK1 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    2Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    3Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    4Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92
    5Cytoplasmic microtubules
    Cytoplasmic microtubules0.32


    Find genes that share SuperPaths with TAOK1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for TAOK1
        MAPK signaling pathway
    p38 MAPK signaling pathway
    Regulation of Microtubule Cytoskeleton

    3 Reactome Pathways for TAOK1
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids


    1 Kegg Pathway  (Kegg details for TAOK1):
        MAPK signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TAOK1
    Interactions:

        GeneGlobe Interaction Network for TAOK1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TAOK1 (Q7L7X32, 3 ENSP000002617164) via UniProtKB, MINT, STRING, and/or I2D (see all 660)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WT1P195442, 3, ENSP000003313274MINT-8277152 I2D: score=2 STRING: ENSP00000331327
    C8orf33Q9H7E92, 3MINT-8250534 I2D: score=2 
    CSNK1EP496742, 3MINT-8252824 I2D: score=2 
    DYNC1I1O145762, 3MINT-8254941 I2D: score=2 
    DAXXQ9UER73I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000165MAPK cascade IBA--
    GO:0000186activation of MAPKK activity IBA--
    GO:0000278mitotic cell cycle TAS--
    GO:0006281DNA repair IEA--
    GO:0006468protein phosphorylation NAS14517247

    Find genes that share ontologies with TAOK1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TAOK1

    2 HMDB Compounds for TAOK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TAOK1 gene (2 alternative transcripts): 
    NM_020791.2  NM_025142.1  

    Unigene Cluster for TAOK1:

    TAO kinase 1
    Hs.597434  [show with all ESTs]
    Unigene Representative Sequence: NM_020791
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000583121 ENST00000261716(uc002hdz.2 uc010wbe.2) ENST00000587277
    ENST00000536202 ENST00000577583(uc002heb.1) ENST00000578653
    miRNA
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    Block miRNA regulation of human, mouse, rat TAOK1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TAOK1 (see all 294):
    hsa-miR-194* hsa-miR-579 hsa-miR-193a-3p hsa-miR-520f hsa-miR-605 hsa-miR-3916 hsa-miR-1273d hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidTAOK1 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): TAOK1 (NM_020791)
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat TAOK1

    Additional mRNA sequence: 

    AB037782.1 AF263312.1 AK025902.1 AL110163.1 AL833649.1 AY049015.1 BC024166.1 BC032793.1 
    BC037535.2 BC037740.2 BC047652.1 BC051737.1 BC062764.1 BC133039.1 BC144067.1 

    9 DOTS entries:

    DT.118228  DT.111869  DT.92436795  DT.100759038  DT.120919270  DT.75158002  DT.91898034  DT.97800864 
    DT.97818284 

    Selected AceView cDNA sequences (see all 82):

    NM_020791 BI715239 AA234623 CA950298 CA950355 CD675669 BE551345 CB160228 
    AA426563 CA397311 BE551394 BM802274 AL707021 CA950530 CA391905 CB159985 
    AB037782 BU532303 BC032793 CA950591 AU158580 AU140588 BX504564 T90218 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TAOK1    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^
    SP1:                          -           -                                   -                                                                                 
    SP2:        -           -                 -                                                                                                                     
    SP3:                                                                                                                                                            
    SP4:                    -                                                                                                                                       

    ExUns: 22
    SP1:      
    SP2:      
    SP3:      
    SP4:      


    ECgene alternative splicing isoforms for TAOK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TAOK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGAAATTTT
    TAOK1 Expression
    About this image


    TAOK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             pre Conventional Dendritic Cells Peripheral Blood
     
     Thymus (Hematopoietic System)
             Double Positive Thymocytes Thymus
     
     Eye (Sensory Organs)
             Retina
    TAOK1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TAOK1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.597434

    UniProtKB/Swiss-Prot: TAOK1_HUMAN, Q7L7X3
    Tissue specificity: Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon
    and skeletal muscle

        Custom PCR Arrays for TAOK1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAOK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TAOK1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Taok11 , 5 TAO kinase 11, 5 93.27(n)1
    99.4(a)1
      11 (46.64 cM)5
    2169651  NM_144825.21  NP_659074.21 
     775291625 
    chicken
    (Gallus gallus)
    Aves TAOK11 TAO kinase 1 87.15(n)
    98.3(a)
      417583  XM_415829.4  XP_415829.4 
    lizard
    (Anolis carolinensis)
    Reptilia TAOK16
    TAO kinase 1
    95(a)
    1 ↔ 1
    GL343462.1(300869-333405)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC529432 similar to serine/threonine protein kinase TAO1 82.69(n)    BC043764.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000045761 serine/threonine-protein kinase TAO1-like 73.57(n)
    85.59(a)
      100004576  XM_001343802.4  XP_001343838.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tao1 Tao 57.93(n)
    58.13(a)
      32948  NM_167666.2  NP_728268.1 
    worm
    (Caenorhabditis elegans)
    Secernentea kin-181 kin-18 51.42(n)
    44.06(a)
      175862  NM_001027596.2  NP_001022767.1 


    ENSEMBL Gene Tree for TAOK1 (if available)
    TreeFam Gene Tree for TAOK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TAOK1 gene
    TAOK22  MAP4K52  TAOK32  NRK2  TNIK2  MAP4K22  MAP4K12  MAP4K32  
    MAP4K42  STK102  MINK12  SLK2  
    8 SIMAP similar genes for TAOK1 using alignment to 2 protein entries:     TAOK1_HUMAN (see all proteins):
    TAOK3    TAOK2    MST4    STK24    STK25    NEK6
    NEK7    STK4

    Find genes that share paralogs with TAOK1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TAOK1 (see all 2918)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1502032471,2
    C--27718250(+) TTTTCC/GTGAGG 2 -- int10--------
    rs1387181601,2
    --27718291(+) TTTCGA/GGGAAG 2 -- int10--------
    rs1179711131,2
    C,F--27718315(+) AGGGAG/AACTGG 2 -- int11Minor allele frequency- A:0.01NA 120
    rs747991811,2
    C,F--27718504(+) AAGCGT/GTTCTC 2 -- int11Minor allele frequency- G:0.05WA 118
    rs1919692741,2
    --27718582(+) CTTCAC/TACACA 2 -- int10--------
    rs1495432441,2
    C--27718652(+) GAAAAG/TGTTAC 2 -- int10--------
    rs1441240381,2
    --27718738(+) TATCTA/GTTCTG 2 -- int10--------
    rs1405743131,2
    --27718875(+) ATTCAA/GATAAA 2 -- int10--------
    rs1842298341,2
    --27718928(+) TATGAC/TTTTTG 2 -- int10--------
    rs1428167641,2
    --27718941(+) GTTCAG/TGAAGA 2 -- int10--------

    HapMap Linkage Disequilibrium report for TAOK1 (27717482 - 27878922 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TAOK1 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2335781CNV Deletion18987734
    esv2673792CNV Deletion23128226
    esv2715797CNV Deletion23290073
    esv2658989CNV Deletion23128226
    esv2474903CNV Deletion19546169
    nsv821292CNV Duplication20802225
    nsv819892CNV Loss19587683
    esv22895CNV Loss19812545
    nsv827940CNV Gain20364138
    nsv833409CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TAOK1
    DNA2.0 Custom Variant and Variant Library Synthesis for TAOK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610266    OMIM disorders: --


    Find genes that share disorders with TAOK1           About GenesLikeMe

    Genetic Association Database (GAD): TAOK1
    Human Genome Epidemiology (HuGE) Navigator: TAOK1 (2 documents)

    Export disorders for TAOK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TAOK1 gene, integrated from 10 sources (see all 67):
    (articles sorted by number of sources associating them with TAOK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. Human TAO kinase 1 induces apoptosis in SH-SY5Y cells. (PubMed id 17900936)1, 2, 9 Wu M.F. and Wang S.G. (Cell Biol. Int. 2008)
    3. MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1. (PubMed id 14517247)1, 3, 9 Timm T....Mandelkow E.M. (EMBO J. 2003)
    4. A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling. (PubMed id 17417629)1, 2, 9 Draviam V.M.... Elledge S.J. (Nat. Cell Biol. 2007)
    5. New gene functions in megakaryopoiesis and platelet formation. (PubMed id 22139419)1, 4 Gieger C....Soranzo N. (Nature 2011)
    6. Re-evaluating the role of Tao1 in the spindle checkpoint. (PubMed id 20162290)1, 2 Westhorpe F.G.... Taylor S.S. (Chromosoma 2010)
    7. Re-examination of siRNA specificity questions role of PICH and Tao1 in the spindle checkpoint and identifies Mad2 as a sensitive target for small RNAs. (PubMed id 19904549)1, 2 Hubner N.C.... Nigg E.A. (Chromosoma 2010)
    8. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. (PubMed id 19820697)1, 4 Soranzo N....Gieger C. (Nat. Genet. 2009)
    9. A genome-wide association study identifies three loci associated with mean platelet volume. (PubMed id 19110211)1, 4 Meisinger C....DAPring A. (Am. J. Hum. Genet. 2009)
    10. TAO kinases mediate activation of p38 in response to DNA damage. (PubMed id 17396146)1, 2 Raman M.... Cobb M.H. (EMBO J. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57551 HGNC: 29259 AceView: KIAA1361 Ensembl:ENSG00000160551 euGenes: HUgn57551
    ECgene: TAOK1 Kegg: 57551 H-InvDB: TAOK1

    (According to HUGE)
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    HUGE: KIAA1361

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TAOK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TAOK1 gene:
    Search GeneIP for patents involving TAOK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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