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TANK Gene

protein-coding GIFtS: 63

GC02P161701

TRAF family member-associated NFKB activator
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: TRAF2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
I-TRAF ^¹, ², ³
ITRAF ^³
TRAF2 ^², ³

Descriptions
TRAF family member-associated NF-KAPPA-B activator ^²
TRAF family member-associated NFKB activator ^²
TRAF interacting protein TANK ^²
TRAF-interacting protein ^³

External Ids
HGNC: 11562¹
Entrez Gene: 10010²
UniProtKB: Q92844³
Ensembl: ENSG00000136560⁷

Search outside databases for aliases for TANK gene

Previous GC identifers: GC02P160047 GC02P160521 GC02P161957 GC02P162196 GC02P161818

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TANK:

The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and

transduce signals from members of the tumor necrosis factor receptor superfamily. The protein

encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby

inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For

example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus

transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Two transcript variants

encoding different isoforms have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: TANK_HUMAN, Q92844

Function: Acts as a regulator of TRAF function by maintaining them in a latent state.

Overexpression inhibits TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.

Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May be involved in

I-kappa-B-kinase (IKK) regulation; may function as an adapter for kinases such as TBK1 or IKBKE

that can modulate IKK activity

Gene Wiki entry for TANK

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TANK gene

Entrez Gene cytogenetic band: 2q24-q31 Ensembl cytogenetic band: 2q24.2 HGNC cytogenetic band: 2q24-q31

TANK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P161701: (about GC identifiers)

Start:	161,701,712 bp from pter
End:	161,800,978 bp from pter
Size:	99,267 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.10 NT_005403.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TANK_HUMAN, Q92844 (See protein sequence)

Recommended Name: TRAF family member-associated NF-kappa-B activator

Size: 425 amino acids; 47816 Da

Subunit: Interacts with TBK1 (via TRAF-C domain). Interacts with TRAF1 (via TRAF-C domain).

Interacts with TRAF2 (via TRAF-C domain); the interaction is disrupted by the phosphorylation of

TANK by IKBKE. Interacts with TRAF3 (via TRAF-C domain); the interaction with TRAF3 is weaker than

the interactions with TRAF1 and TRAF3. Interacts with IKBKG; the interaction is enhanced by IKBKE

and TBK1. Part of a ternary complex consisting of TANK, IKBKB and IKBKG

Subcellular location: Cytoplasm

PDB structure from and Proteopedia :

1KZZ (3D)

1L0A (3D)

Secondary accessions: Q92885

Alternative splicing: 2 isoforms: Q92844-1 Q92844-2

Post-translational modifications:

Phosphorylated by IKBKE¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_004171.2 NP_597841.1

ENSEMBL proteins:

ENSP00000384492 ENSP00000384235 ENSP00000259075 ENSP00000376505 ENSP00000385487 ENSP00000385983

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (TANK)
	Human Recombinant Proteins from Abnova (TANK)

OriGene Purified Recombinant Human Protein: TANK

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

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Antibodies for TANK:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for TANK
	R&D Systems Antibodies for TANK
	Cell Signaling Technology (CST) Antibodies for TANK
	Antibodies from Abcam (TANK), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TANK)
	Novus Biologicals Antibodies for TANK

Assays for TANK:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q92844

ProtoNet protein and cluster: Q92844

UniProtKB/Swiss-Prot: TANK_HUMAN, Q92844

Similarity: Contains 1 C2H2-type zinc finger

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TANK)
		Millipore RNAi Products for the Analysis of TANK Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (TANK)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_004180

Applied Biosystems Silencer® siRNAs for TANK

Sigma-Aldrich siRNA and siRNA Panels for TANK

Sigma-Aldrich shRNA for TANK

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for TANK
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004180
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004180
untagged cDNA clones in CMV expression vector (see all 2): NM_004180

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004180

UniProtKB/Swiss-Prot: TANK_HUMAN, Q92844

Function: Acts as a regulator of TRAF function by maintaining them in a latent state.

Overexpression inhibits TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.

Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May be involved in

I-kappa-B-kinase (IKK) regulation; may function as an adapter for kinases such as TBK1 or IKBKE

that can modulate IKK activity

Genatlas biochemistry entry for TANK:

tumor necrosis receptor-associated factor ,TRAF-interacting protein,mediator of NFKB activation

after induction by TRAF2

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	12005438
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for TANK (Your Favorite Gene powered by Ingenuity)

Role of RIG1-like Receptors in Antiviral Innate Immunity
Activation of IRF by Cytosolic Pattern Recognition Receptors
Death Receptor Signaling
CD40 Signaling

GeneDecks TANK for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for TANK

5/62 Interacting proteins for TANK (ENSP00000259075³ Q92844^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 62 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TBK1	Q9UHD2²	STRING (score=.999) MINT-5114997 MINT-49268 MINT-49290 MINT-48040 MINT-6492446 MINT-48264
TRAF2	Q12933²	STRING (score=.971) MINT-47974 MINT-48259
IKBKE	Q14164²	STRING (score=.999) MINT-5115012
TRAF3	Q13114¹^,²	STRING (score=.999) EBI-356349, EBI-357631 MINT-48252 MINT-47975 EBI-356349, EBI-357631 MINT-48252 MINT-47975
TRAF3	Q13114¹^,²	STRING (score=.999) EBI-356349, EBI-357631 MINT-48252 MINT-47975 EBI-356349, EBI-357631 MINT-48252 MINT-47975

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	8710854

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TANK
1 Novoseek chemical compound relationship for TANK gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	15.62	5	15383523 (1), 8702708 (1), 16336209 (1), 8692885 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TANK)
		Millipore RNAi Products for the Analysis of TANK Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (TANK)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_004180

Sigma-Aldrich siRNA and siRNA Panels for TANK

Sigma-Aldrich shRNA for TANK

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004180 NM_133484

REFSEQ mRNAs for TANK gene (2 alternative transcripts):

NM_004180.2 NM_133484.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004180 NM_133484

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004180
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004180
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004180

Additional cDNA sequence:

AK313096.1 BC003388.1 BC067779.1 BT009855.1 CR602454.1 CR612977.1 U59863.1 U63830.1

21 DOTS entries:

DT.91675628 DT.217271 DT.95275688 DT.91738433 DT.121025985 DT.86836152 DT.205093 DT.40113470

DT.100025328 DT.100782241 DT.92021857 DT.97763505 DT.100659606 DT.100782242 DT.101981250 DT.121025965

DT.40132141 DT.92024293 DT.96085145 DT.121025952 DT.95295476

24/203 AceView cDNA sequences (see all 203 ):

BM680474 T30861 BX436856 CR612977 AW966902 CB054258 BU736055 F04517

H84182 AA484829 AW615381 AU139286 AA134813 NM_133484 AI139083 AW967525

AI440070 CR602454 BG680246 AI090614 AU279460 AA765575 BX091561 AW950654

highest scoring ESTs for TANK:

U59863 AA031454 AA134814 AA580060 AA765575 AA837280 AI090614 AI499100 AI581820 AI769398

Unigene Cluster for TANK:

TRAF family member-associated NFKB activator

Hs.132257 [show with all ESTs]

Unigene Representative Sequence: NM_004180

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TANK (see all 11 )

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	·	7c	·	7d	^	8	^	9a	·	9b	·	9c	^	10	^	11	^	12a	·	12b	^	13a	·	13b	·	13c	^	14	^
SP1:											-		-		-		-		-		-						-								-		-														-
SP2:					-		-		-		-		-		-		-		-		-						-								-		-														-
SP3:											-		-		-		-		-		-		-				-								-		-
SP4:																											-								-		-
SP5:											-		-		-		-		-		-						-

ExUns:	15a	·	15b
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for TANK

6 Ensembl transcripts including schematic representations:

ENST00000406287 ENST00000402568 ENST00000259075 ENST00000392749 ENST00000405852 ENST00000403609

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TANK expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TANK

¹ / ² / ³

7 probe-sets matching TANK gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39742_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U59863	1.00	1.00	1.00	1
210458_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC003388	0.60	1.00	0.82	1
209451_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U59863	1.00	1.00	1.00	1
207616_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004180	0.60	1.00	0.82	1
210458_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209451_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
207616_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATGAAATTAA

SOURCE GeneReport for Unigene cluster: Hs.132257
Expression variation in blood from EXPOLDB for TANK
UniProtKB/Swiss-Prot: TANK_HUMAN, Q92844
Tissue specificity: Ubiquitous

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TANK gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TANK¹	--	TRAF family member-associated NFKB activator	90.12(n) 87.06(a)	608092 XM_844996.1 XP_850089.1
chimpanzee (Pan troglodytes)	TANK¹	--	TRAF family member-associated NFKB activator	99.53(n) 99.29(a)	459685 XM_001149990.1 XP_001149990.1
cow (Bos taurus)	TANK¹	--	TRAF family member-associated NFKB activator	90.09(n) 85.68(a)	539513 XM_587821.3 XP_587821.3
rat (Rattus norvegicus)	Tank¹	--	TRAF family member-associated NFKB activator	86.52(n) 81.6(a)	252961 NM_145788.1 NP_665731.1
mouse (Mus musculus)	Tank^{1, 5}	2⁵	TRAF family member-associated Nf-kappa B activator^{1, 5}	86.52(n)¹ 82.08(a)¹	21353¹ NM_011529.1¹ NP_035659.1¹ AK031559⁵ AK038910⁵ (see all 22)

About this table Species with no ortholog for TANK

ENSEMBL Gene Tree for TANK

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/290 NCBI SNPs in TANK are shown (see all 290 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 128)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs979415^1,2	A,C,F,H,O	161700489(+)	`CCATAG/ATTCCA`	2	--	ng5¹		14	EA NA NS EU WA	672
	rs3754978^1,2	A,C,F,H	161699904(-)	`GGAGTC/TGTAAA`	2	--	ng5¹		8	EA EU WA NA	2042
	rs7309^1,2	A,C,F,H	161800886(+)	`TTACTG/ATGTGT`	1	--	ut3¹ ese³		10	MN EU EA WA NA	1152
	rs3754976^1,2	A,C,F,H	161701187(-)	`GACAGC/GTTTTC`	2	--	ng5¹		5	EA EU WA	1890
	rs10183668^1,2	C,F,H	161796081(+)	`TTCAGG/AGAATT`	1	R/G	mis¹ ese³		5	EU EA WA NA	484
	rs979414^1,2	A,C,F	161700170(+)	`CAGGAT/GCCTGG`	2	--	ng5¹ tfbs³		5	EA NA MN	1720
--	rs1267050^1,2	C,F,H	161769811(+)	`acacaG/Ctgact`	2	--	int¹ ng3¹		8	MN EU EA WA NA	734
	rs3769969^1,2	C,F,H	161800178(-)	`ATACTC/TGAGGT`	1	R/Q	mis¹ ese³		9	EA EU WA	2314
	rs3754975^1,2	F	161701488(-)	`AACAAC/TAACAA`	2	--	ng5¹		1	EA	1498
--	rs2229759^1,2	F	161796280(+)	`TTCCCC/TGGGAA`	1	P/L	mis¹ ese³		2	MN NA	134

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HapMap Linkage Disequilibrium images for TANK (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603893

4 Novoseek disease relationships for TANK gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	62.71	13	11112773 (1), 7859281 (1), 9153189 (1), 8702708 (1) (see all 13)
tumors	42.43	15	11112773 (1), 7859281 (1), 9153189 (1), 17633021 (1) (see all 13)
latent infection	37.21	1	11932422 (1)
hyperplasia	0.00	1	16888677 (1)

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Human Genome Epidemiology Navigator: TANK (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

FDA Approves Protopic (Tacrolimus) Non-Steroidal Ointment For Eczema

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/77 PubMed articles for TANK gene (see all 77 ):

I-TRAF is a novel TRAF-interacting protein that regulates TRAF- mediated signal transduction. (PubMed id 8710854)^{1, 2, 3, 4} Rothe M....Goeddel D.V. (1996)
Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein. (PubMed id 8855313)^{2, 3, 4} Kaye K.M....Mosialos G. (1996)
NF-kB activation by a signaling complex containing TRAF2, TANK, and TBK1, a novel IKK-related kinase. (PubMed id 10581243)^{1, 3, 4} Pomerantz J.L. and Baltimore D. (1999)
Downstream regulator TANK binds to the CD40 recognition site on TRAF3. (PubMed id 12005438)^{1, 3, 4} Li C.... Ely K.R. (2002)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases. (PubMed id 12133833)^{3, 4} Chariot A.... Siebenlist U. (2002)
NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation. (PubMed id 10759890)^{3, 4} Nomura F....Akira S. (2000)
TANK potentiates tumor necrosis factor receptor-associated factor-mediated c-Jun N-terminal kinase/stress-activated protein kinase activation through the germinal center kinase pathway. (PubMed id 10490605)^{1, 3} Chin A.I....Cheng G. (1999)
Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF. (PubMed id 17823124)^{1, 3} Gatot J.S....Chariot A. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 10010	HGNC: 11562	AceView: TANK	Ensembl:ENSG00000136560	euGenes: HUgn10010
ECgene: TANK	H-InvDB: TANK

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for TANK	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for TANK
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TANK:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TANK-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TANK		Antibodies for TANK
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TANK		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TANK)
	Antibodies (TANK)
	Chimera RNAi (TANK)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for TANK

	Recombinant Proteins (TANK)
	Antibodies (TANK)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for TANK

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TANK

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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TANK Gene at Home site.
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TANK Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for TANK

Summaries
for TANK

Genomic Location
for TANK

Proteins
for TANK

Protein Domains/
Families
for TANK

Gene Function
for TANK

Pathways & Interactions
for TANK

Drugs & Compounds
for TANK

Transcripts
for TANK

Expression
for TANK

Orthologs
for TANK

Paralogs
for TANK

SNPs/Variants
for TANK

Disorders & Mutations
for TANK

Medical News
for TANK

Publications
for TANK

Search for TANK

Genome Databases showing TANK

Other Databases showing TANK

Specialized Databases showing TANK

Licensable Technologies
for TANK

Services
for TANK

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TANK Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor TANK

Summariesfor TANK

Genomic Locationfor TANK

Proteinsfor TANK

Protein Domains/Familiesfor TANK

Gene Functionfor TANK

Pathways & Interactionsfor TANK

Drugs & Compoundsfor TANK

Transcriptsfor TANK

Expression for TANK

Orthologsfor TANK

Paralogsfor TANK

SNPs/Variantsfor TANK

Disorders & Mutationsfor TANK

Medical Newsfor TANK

Publicationsfor TANK

Search for TANK

Genome Databases showing TANK

Other Databases showing TANK

Specialized Databases showing TANK

Licensable Technologiesfor TANK

Servicesfor TANK

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TANK

Summaries
for TANK

Genomic Location
for TANK

Proteins
for TANK

Protein Domains/
Families
for TANK

Gene Function
for TANK

Pathways & Interactions
for TANK

Drugs & Compounds
for TANK

Transcripts
for TANK

Expression
for TANK

Orthologs
for TANK

Paralogs
for TANK

SNPs/Variants
for TANK

Disorders & Mutations
for TANK

Medical News
for TANK

Publications
for TANK

Licensable Technologies
for TANK

Services
for TANK