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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TANK Gene

protein-coding   GIFtS: 63
GCID: GC02P161957

TRAF Family Member-Associated NFKB Activator


(Previous symbol: TRAF2)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TRAF Family Member-Associated NFKB Activator1 2
TRAF21 2 3
I-TRAF2 3
ITRAF2 3
TRAF-Interacting Protein2 3
TRAF Family Member-Associated NF-Kappa-B Activator2

External Ids:    HGNC: 115621   Entrez Gene: 100102   Ensembl: ENSG000001365607   OMIM: 6038935   UniProtKB: Q928443   

Export aliases for TANK gene to outside databases

Previous GC identifers: GC02P160047 GC02P160521 GC02P162196 GC02P161818 GC02P161701 GC02P153878


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TANK Gene:
The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce
signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found
in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the
TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding
to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three
alternatively spliced transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Nov 2010)

GeneCards Summary for TANK Gene: 
TANK (TRAF family member-associated NFKB activator) is a protein-coding gene. Diseases associated with TANK include ellis-van creveld syndrome, and open-angle glaucoma, and among its related super-pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and DR3 Signaling. GO annotations related to this gene include metal ion binding and ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot: TANK_HUMAN, Q92844
Function: Acts as a regulator of TRAF function by maintaining them in a latent state. Overexpression inhibits
TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Blocks TRAF2 binding to LMP1 and inhibits
LMP1-mediated NF-kappa-B activation. May be involved in I-kappa-B-kinase (IKK) regulation; may function as an
adapter for kinases such as TBK1 or IKBKE that can modulate IKK activity

Gene Wiki entry for TANK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TANK gene promoter:
         SREBP-1a   deltaCREB   SREBP-1c   IRF-7A   NF-kappaB1   NF-kappaB   SREBP-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TANK promoter sequence
   Search SABiosciences Chromatin IP Primers for TANK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TANK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24-q31   Ensembl cytogenetic band:  2q24.2   HGNC cytogenetic band: 2q24-q31

TANK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TANK gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P161957:  view genomic region     (about GC identifiers)

Start:
161,993,419 bp from pter      End:
162,092,732 bp from pter
Size:
99,314 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TANK_HUMAN, Q92844 (See protein sequence)
Recommended Name: TRAF family member-associated NF-kappa-B activator  
Size: 425 amino acids; 47816 Da
Subunit: Interacts with TBK1 (via TRAF-C domain). Interacts with TRAF1 (via TRAF-C domain). Interacts with TRAF2
(via TRAF-C domain); the interaction is disrupted by the phosphorylation of TANK by IKBKE. Interacts with TRAF3
(via TRAF-C domain); the interaction with TRAF3 is weaker than the interactions with TRAF1 and TRAF3. Interacts
with IKBKG; the interaction is enhanced by IKBKE and TBK1. Part of a ternary complex consisting of TANK, IKBKB
and IKBKG
Subcellular location: Cytoplasm
2 PDB 3D structures from and Proteopedia for TANK:
1KZZ (3D)        1L0A (3D)    
Secondary accessions: D3DPB5 Q7Z4J6 Q92885
Alternative splicing: 3 isoforms:  Q92844-1   Q92844-2   Q92844-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TANK: NX_Q92844

Explore proteomics data for TANK at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by IKBKE
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92844

  • TANK Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TANK Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_004171.2  NP_597841.1  NP_001186064.1  

    ENSEMBL proteins: 
     ENSP00000259075   ENSP00000398157   ENSP00000376505   ENSP00000399934   ENSP00000411041  
     ENSP00000384492   ENSP00000384235   ENSP00000388930   ENSP00000410259   ENSP00000412622  
     ENSP00000385487   ENSP00000392776   ENSP00000385983   ENSP00000412556   ENSP00000387439  
     ENSP00000415276  
    Reactome Protein details: Q92844
    Human Recombinant Protein Products for TANK: 
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    Novus Biologicals TANK Proteins
    Novus Biologicals TANK Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for TANK
    Cloud-Clone Corp. Proteins for TANK 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--

    TANK for ontologies           About GeneDecksing



    TANK Antibody Products: 
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    Novus Biologicals TANK Antibodies
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    ThermoFisher Antibody for TANK
    LSBio Antibodies in human, mouse, rat for TANK 

    Assay Products for TANK: 
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    Cloud-Clone Corp. ELISAs for TANK 
    Cloud-Clone Corp. CLIAs for TANK


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR024581 TBD

    Graphical View of Domain Structure for InterPro Entry Q92844

    ProtoNet protein and cluster: Q92844

    UniProtKB/Swiss-Prot: TANK_HUMAN, Q92844
    Similarity: Contains 1 C2H2-type zinc finger


    TANK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TANK_HUMAN, Q92844
    Function: Acts as a regulator of TRAF function by maintaining them in a latent state. Overexpression inhibits
    TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Blocks TRAF2 binding to LMP1 and inhibits
    LMP1-mediated NF-kappa-B activation. May be involved in I-kappa-B-kinase (IKK) regulation; may function as an
    adapter for kinases such as TBK1 or IKBKE that can modulate IKK activity

         Genatlas biochemistry entry for TANK:
    tumor necrosis receptor-associated factor ,TRAF-interacting protein,mediator of NFKB activation after induction by
    TRAF2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12005438
    GO:0031625ubiquitin protein ligase binding IPI11279055
    GO:0046872metal ion binding IEA--
         
    TANK for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TANK:
     Increased G1 DNA content 

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tank):
     cellular  hematopoietic system  immune system  liver/biliary system  mortality/aging 
     renal/urinary system  respiratory system 

    TANK for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tanktm1Aki for TANK

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TANK 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TANK

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TANK 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TANK 

    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate TANK (see all 13):
    hsa-miR-30c hsa-miR-3671 hsa-miR-3607-3p hsa-miR-607 hsa-miR-30d hsa-miR-1297 hsa-miR-183* hsa-miR-656
    SwitchGear 3'UTR luciferase reporter plasmidTANK 3' UTR sequence
    Inhib. RNA
    Products:
        
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    GenScript: all cDNA clones in your preferred vector (see all 3): TANK (NM_001199135)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TANK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TANK
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                         Customized lentivirus expression plasmids for stable overexpression of TANK 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TANK


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TANK About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.52
    RIG-I-like receptor signaling pathway0.52
    2TWEAK Pathway
    TNFR1 Pathway0.56
    TNF Signaling0.55
    3Immune System
    Immune System0.56
    Innate Immune System0.50
    4TRAF Pathway
    TRAF Pathway0.42
    Toll-Like Receptors Pathway0.41
    5Toll-Like receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.59

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TANK
        Toll-Like receptor Signaling Pathways

    5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TANK
        TNF Signaling
    Toll-Like Receptors Pathway
    TRAF Pathway
    TNFR2 Pathway
    TNFR1 Pathway

    2 Cell Signaling Technology (CST) Pathways for TANK
        Apoptosis and Autophagy
    NF-kappaB Signaling

    1 BioSystems Pathway for TANK
        TNF-alpha/NF-kB Signaling Pathway

    4        Reactome Pathways for TANK
        RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    TRAF6 mediated IRF7 activation
    Immune System
    Innate Immune System


    1         Kegg Pathway  (Kegg details for TANK):
        RIG-I-like receptor signaling pathway


    TANK for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TANK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/77 Interacting proteins for TANK (Q928441, 2, 3 ENSP000002590754) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TBK1Q9UHD21, 2, 3, ENSP000003299674EBI-356349,EBI-356402 MINT-5114997 MINT-8144259 MINT-49268 MINT-49290 MINT-48040 MINT-6492446 MINT-8151323 MINT-48264 I2D: score=8 STRING: ENSP00000329967
    SUMO1P631652, 3, ENSP000003760764MINT-8144259 MINT-8151307 MINT-8144047 MINT-8144064 MINT-8144154 MINT-8144012 MINT-8144107 MINT-8151323 I2D: score=1 STRING: ENSP00000376076
    ENSG00000206383P349312, 3MINT-48247 I2D: score=2 
    ENSG00000234258P349312, 3MINT-48247 I2D: score=2 
    ENSG00000236251P349312, 3MINT-48247 I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS8710854
    GO:0007249I-kappaB kinase/NF-kappaB cascade IEA--
    GO:0045087innate immune response TAS--

    TANK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TANK for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TANK

    1 Novoseek inferred chemical compound relationship for TANK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 13.1 5 15383523 (1), 8702708 (1), 16336209 (1), 8692885 (1)

    Search CenterWatch for drugs/clinical trials and news about TANK

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TANK gene (3 alternative transcripts): 
    NM_004180.2  NM_133484.1  NM_001199135.1  

    Unigene Cluster for TANK:

    TRAF family member-associated NFKB activator
    Hs.132257  [show with all ESTs]
    Unigene Representative Sequence: NM_004180
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000259075(uc002ubr.2) ENST00000432002 ENST00000463502 ENST00000392749(uc002ubs.3)
    ENST00000440506 ENST00000461338 ENST00000429217 ENST00000406287 ENST00000402568
    ENST00000457887 ENST00000477952 ENST00000441987 ENST00000432692 ENST00000494976
    ENST00000405852 ENST00000483622 ENST00000456358 ENST00000468831
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate TANK (see all 13):
    hsa-miR-30c hsa-miR-3671 hsa-miR-3607-3p hsa-miR-607 hsa-miR-30d hsa-miR-1297 hsa-miR-183* hsa-miR-656
    SwitchGear 3'UTR luciferase reporter plasmidTANK 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TANK

    Additional mRNA sequence: 

    AK313096.1 BC003388.1 BC067779.1 BT009855.1 U59863.1 U63830.1 

    18 DOTS entries:

    DT.91675628  DT.217271  DT.95275688  DT.91738433  DT.121025985  DT.100025328  DT.100782242  DT.92021857 
    DT.100659606  DT.100782241  DT.101981250  DT.121025965  DT.40132141  DT.92024293  DT.96085145  DT.97763505 
    DT.40113470  DT.95295476 

    24/203 AceView cDNA sequences (see all 203):

    CB054258 CR602454 AW615381 CR612977 BX091561 AW236447 T96025 T36204 
    BM718019 AA134813 AI090614 R09657 F04517 BC003388 AA765575 AU279460 
    AW967525 Z39773 T30861 AW950654 AI289412 AL532012 AU139286 AI139083 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TANK (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^
    SP1:                                -     -     -     -     -     -                 -                       -     -                                         -   
    SP2:              -     -     -     -     -     -     -     -     -                 -                       -     -                                         -   
    SP3:                                -     -     -     -     -     -     -           -                       -     -                                             
    SP4:                                                                                -                       -     -                                             
    SP5:                                -     -     -     -     -     -                 -                                                                           

    ExUns: 15a · 15b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for TANK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TANK expression in normal human tissues (normalized intensities)      TANK embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGAAATTAA
    TANK Expression
    About this image


    TANK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/32 selected tissues (see all 32) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   

    See TANK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TANK

    SOURCE GeneReport for Unigene cluster: Hs.132257

    UniProtKB/Swiss-Prot: TANK_HUMAN, Q92844
    Tissue specificity: Ubiquitous

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TANK gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tank1 , 5 TRAF family member-associated Nf-kappa B activator1, 5 86.52(n)1
    82.08(a)1
      2 (35.56 cM)5
    213531  NM_011529.21  NP_035659.11 
     615785855 
    chicken
    (Gallus gallus)
    Aves TANK1 TRAF family member-associated NFKB activator 64.35(n)
    48.44(a)
      424190  XM_422036.2  XP_422036.1 
    lizard
    (Anolis carolinensis)
    Reptilia TANK6
    TRAF family member-associated NFKB activator
    40(a)
    1 ↔ 1
    GL343371.1(58837-123981)
    zebrafish
    (Danio rerio)
    Actinopterygii tank1 TRAF family member-associated NFKB activator 47.28(n)
    32.22(a)
      767660  NM_001076600.1  NP_001070068.1 


    ENSEMBL Gene Tree for TANK (if available)
    TreeFam Gene Tree for TANK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1546 SNPs in TANK are shown (see all 1546)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37549781,2
    C,F,A,H--161991658(-) GGAGTC/TGTAAA 2 -- us2k112Minor allele frequency- T:0.20EA NA NS WA 2402
    rs1898673161,2
    --161991683(+) GGTGGA/GGAGTA 2 -- us2k10--------
    rs1181011461,2
    F--161991773(+) CTGGTT/CAGTGG 2 -- us2k11Minor allele frequency- C:0.01EA 120
    rs1168949481,2
    C,F--161991842(+) TTCTCT/CGTTTT 2 -- us2k11Minor allele frequency- C:0.06EA 120
    rs1488504601,2
    --161991850(+) TTTGGA/CTGTAG 2 -- us2k10--------
    rs1469948651,2
    --161991904(+) CCCTGC/GAGTAG 2 -- us2k10--------
    rs9794141,2
    C,F,A--161991924(+) CAGGAT/GCCTGG 2 -- us2k1 tfbs39Minor allele frequency- G:0.20EA NA MN WA 1956
    rs1476179901,2
    --161991932(+) TGGGTA/GTCAGC 2 -- us2k10--------
    rs1820282061,2
    --161992022(+) AGACAA/GGAGCG 2 -- us2k10--------
    rs790312051,2
    C--161992207(+) ATATTC/TAGCAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TANK (161993419 - 162092732 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for TANK:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2670224CNV Deletion23128226
    nsv3004CNV Insertion18451855
    nsv507044CNV Insertion20534489
    esv270537CNV Insertion20981092
    nsv459934CNV Loss19166990
    nsv437557CNV Loss16327808
    nsv834437CNV Gain17160897
    esv259615OTHER Complex20981092

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603893    OMIM disorders: --

    18 diseases for TANK:    About MalaCards
    ellis-van creveld syndrome    open-angle glaucoma    primary open angle glaucoma    glaucoma
    hepatitis b virus infection    multiple myeloma    non-hodgkin lymphoma    hodgkin's lymphoma
    myeloma    astrocytoma    type 1 diabetes    hepatitis c
    cervicitis    rheumatoid arthritis    arthritis    hepatitis b
    endotheliitis    hepatitis


    TANK for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for TANK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 62.6 13 11112773 (1), 7859281 (1), 9153189 (1), 8702708 (1) (see all 13)
    tumors 42.3 15 11112773 (1), 7859281 (1), 9153189 (1), 17633021 (1) (see all 13)
    latent infection 34.9 1 11932422 (1)
    hyperplasia 0 1 16888677 (1)

    Genetic Association Database (GAD): TANK
    Human Genome Epidemiology (HuGE) Navigator: TANK (14 documents)

    Export disorders for TANK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TANK gene, integrated from 9 sources (see all 122):
    (articles sorted by number of sources associating them with TANK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. I-TRAF is a novel TRAF-interacting protein that regulates TRAF- mediated signal transduction. (PubMed id 8710854)1, 2, 3, 9 Rothe M....Goeddel D.V. (1996)
    2. Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein. (PubMed id 8855313)1, 2, 3 Kaye K.M.... Mosialos G. (1996)
    3. NF-kB activation by a signaling complex containing TRAF2, TANK, and TBK1, a novel IKK-related kinase. (PubMed id 10581243)1, 2, 9 Pomerantz J.L. and Baltimore D. (1999)
    4. Downstream regulator TANK binds to the CD40 recognition site on TRAF3. (PubMed id 12005438)1, 2, 9 Li C.... Ely K.R. (2002)
    5. Large-scale candidate gene analysis of spontaneous cl earance of hepatitis C virus. (PubMed id 20331378)1, 4, 9 Mosbruger T.L....Thio C.L. (2010)
    6. Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients. (PubMed id 19262425)1, 4, 9 Bowes J.D....Barton A. (2009)
    7. Common single nucleotide polymorphisms in immunoregul atory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (2010)
    8. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    9. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
    10. Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10010 HGNC: 11562 AceView: TANK Ensembl:ENSG00000136560 euGenes: HUgn10010
    ECgene: TANK Kegg: 10010 H-InvDB: TANK

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TANK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TANK Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TANK gene:
    Search GeneIP for patents involving TANK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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