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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TANK Gene

protein-coding GIFtS: 60
GCID: GC02P161957

TRAF family member-associated NFKB activator

(Previous symbol: TRAF2)

Explore 17 diseases affiliated with
TANK via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
TRAF Family Member-Associated NFKB Activator¹ ²
I-TRAF¹ ² ³
TRAF2¹ ² ³
TRAF-Interacting Protein² ³
TRAF Family Member-Associated NF-Kappa-B Activator²
ITRAF³

External Ids:	HGNC: 11562¹	Entrez Gene: 10010²	Ensembl: ENSG00000136560⁷	OMIM: 603893⁵	UniProtKB: Q92844³

Export aliases for TANK gene to outside databases

Previous GC identifers: GC02P160047 GC02P160521 GC02P162196 GC02P161818 GC02P161701 GC02P153878

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TANK:

The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals

from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the

cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a

latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the

Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced

transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Nov 2010)

UniProtKB/Swiss-Prot: TANK_HUMAN, Q92844

Function: Acts as a regulator of TRAF function by maintaining them in a latent state. Overexpression inhibits

TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Blocks TRAF2 binding to LMP1 and inhibits

LMP1-mediated NF-kappa-B activation. May be involved in I-kappa-B-kinase (IKK) regulation; may function as an adapter

for kinases such as TBK1 or IKBKE that can modulate IKK activity

Gene Wiki entry for TANK

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TANK gene promoter:
SREBP-1a deltaCREB SREBP-1c IRF-7A NF-kappaB1 NF-kappaB SREBP-1b
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TANK promoter sequence

Search SABiosciences Chromatin IP Primers for TANK

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TANK

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24-q31 Ensembl cytogenetic band: 2q24.2 HGNC cytogenetic band: 2q24-q31

TANK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TANK gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P161957: view genomic region (about GC identifiers)

Start:	161,993,419 bp from pter	End:	162,092,732 bp from pter
Size:	99,314 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TANK_HUMAN, Q92844 (See protein sequence)

Recommended Name: TRAF family member-associated NF-kappa-B activator

Size: 425 amino acids; 47816 Da

Subunit: Interacts with TBK1 (via TRAF-C domain). Interacts with TRAF1 (via TRAF-C domain). Interacts with TRAF2 (via

TRAF-C domain); the interaction is disrupted by the phosphorylation of TANK by IKBKE. Interacts with TRAF3 (via TRAF-C

domain); the interaction with TRAF3 is weaker than the interactions with TRAF1 and TRAF3. Interacts with IKBKG; the

interaction is enhanced by IKBKE and TBK1. Part of a ternary complex consisting of TANK, IKBKB and IKBKG

Subcellular location: Cytoplasm

2 PDB 3D structures from and Proteopedia for TANK:

1KZZ (3D)

1L0A (3D)

Secondary accessions: D3DPB5 Q7Z4J6 Q92885

Alternative splicing: 3 isoforms: Q92844-1 Q92844-2 Q92844-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TANK: NX_Q92844

Post-translational modifications:

Phosphorylated by IKBKE¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q92844

TANK Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_004171.2 NP_597841.1 NP_001186064.1

ENSEMBL proteins:

ENSP00000259075 ENSP00000398157 ENSP00000376505 ENSP00000399934 ENSP00000411041

ENSP00000384492 ENSP00000384235 ENSP00000388930 ENSP00000410259 ENSP00000412622

ENSP00000385487 ENSP00000392776 ENSP00000385983 ENSP00000412556 ENSP00000387439

ENSP00000415276

Reactome Protein details: Q92844
Human Recombinant Protein Products:

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	Novus Biologicals TANK Proteins Novus Biologicals TANK Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TANK

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	TAS	--

TANK for ontologies About GeneDecksing

TANK Antibody Products:

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	ThermoFisher Antibody for TANK

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	Uscn ELISAs and CLIAs for TANK

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TANK for domains About GeneDecksing

1 InterPro domain/family:

IPR024581 TBD

Graphical View of Domain Structure for InterPro Entry Q92844

ProtoNet protein and cluster: Q92844

UniProtKB/Swiss-Prot: TANK_HUMAN, Q92844

Similarity: Contains 1 C2H2-type zinc finger

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TANK_HUMAN, Q92844

Function: Acts as a regulator of TRAF function by maintaining them in a latent state. Overexpression inhibits

TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Blocks TRAF2 binding to LMP1 and inhibits

LMP1-mediated NF-kappa-B activation. May be involved in I-kappa-B-kinase (IKK) regulation; may function as an adapter

for kinases such as TBK1 or IKBKE that can modulate IKK activity

Genatlas biochemistry entry for TANK:

tumor necrosis receptor-associated factor ,TRAF-interacting protein,mediator of NFKB activation after induction by

TRAF2

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TANK Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TANK
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate TANK (see all 13):
		hsa-miR-30c hsa-miR-3671 hsa-miR-3607-3p hsa-miR-607 hsa-miR-30d hsa-miR-1297 hsa-miR-183* hsa-miR-656

		SwitchGear 3'UTR luciferase reporter plasmid: TANK 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TANK (see all 7) OriGene shRNA RFP: TANK OriGene siRNA: TANK
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Gene Editing
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DNA2.0 Custom Protein Engineering Service for TANK

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		GenScript: all cDNA clones in your preferred vector (see all 3): TANK (NM_001199135)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TANK
		Search LifeMap BioReagents cell lines for TANK

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TANK

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	--
GO:0031625	ubiquitin protein ligase binding	IPI	11279055
GO:0046872	metal ion binding	IEA	--

TANK for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for TANK:

Increased G1 DNA content

Animal Models:
Mouse knock-out Tank^tm1Aki for TANK
7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tank):

cellular	hematopoietic system	immune system	liver/biliary system	mortality/aging
renal/urinary system	respiratory system

TANK for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Immune System

Immune System

1.00

Innate Immune System

0.46

TRAF Pathway

TRAF Pathway

1.00

Toll-Like Receptors Pathway

0.41

RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways

RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways

1.00

RIG-I-like receptor signaling pathway

0.52

TWEAK Pathway

TNFR1 Pathway

0.53

TNF Signaling

0.40

Apoptosis and Autophagy

Apoptosis and Autophagy

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 R&D Systems Pathway for TANK

Toll-Like receptor Signaling Pathways

5 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TANK

	TNF Signaling
	Toll-Like Receptors Pathway
	TRAF Pathway
	TNFR2 Pathway
	TNFR1 Pathway

2 Cell Signaling Technology (CST) Pathways for TANK

	Apoptosis and Autophagy
	NF-kappaB Signaling

1 BioSystems Pathway for TANK

TNF-alpha/NF-kB Signaling Pathway

4 Reactome Pathways for TANK

	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
	TRAF6 mediated IRF7 activation
	Immune System
	Innate Immune System

1 Kegg Pathway (Kegg details for TANK):

RIG-I-like receptor signaling pathway

TANK for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TANK

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/73 Interacting proteins for TANK (Q92844^{1, 2, 3} ENSP00000259075⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 73)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TBK1	Q9UHD2¹^,²^,³, ENSP00000329967⁴	EBI-356349,EBI-1383470 MINT-5114997 MINT-8144259 MINT-49268 MINT-49290 MINT-48040 MINT-6492446 MINT-8151323 MINT-48264 I2D: score=8 STRING: ENSP00000329967
SUMO1	P63165²^,³, ENSP00000376076⁴	MINT-8144259 MINT-8151307 MINT-8144047 MINT-8144064 MINT-8144154 MINT-8144012 MINT-8144107 MINT-8151323 I2D: score=1 STRING: ENSP00000376076
CALM2	P62158²^,³	MINT-48261 I2D: score=2
CALM3	P62158²^,³	MINT-48261 I2D: score=2
IARS	P41252²^,³, ENSP00000364794⁴	MINT-48253 I2D: score=2 STRING: ENSP00000364794

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	8710854
GO:0007249	I-kappaB kinase/NF-kappaB cascade	IEA	--
GO:0045087	innate immune response	TAS	--

TANK for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TANK for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TANK
1 Novoseek chemical compound relationship for TANK gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	13.1	5	15383523 (1), 8702708 (1), 16336209 (1), 8692885 (1)

Search CenterWatch for drugs/clinical trials and news about TANK

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TANK gene (3 alternative transcripts):

NM_004180.2 NM_133484.1 NM_001199135.1

Unigene Cluster for TANK:

TRAF family member-associated NFKB activator

Hs.132257 [show with all ESTs]

Unigene Representative Sequence: NM_004180

18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):

ENST00000259075(uc002ubr.2) ENST00000432002 ENST00000463502 ENST00000392749(uc002ubs.3)

ENST00000440506 ENST00000461338 ENST00000429217 ENST00000406287 ENST00000402568

ENST00000457887 ENST00000477952 ENST00000441987 ENST00000432692 ENST00000494976

ENST00000405852 ENST00000483622 ENST00000456358 ENST00000468831

miRNA Products:		OriGene 3'-UTR Clone (see all 2): TANK Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TANK
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate TANK (see all 13):
		hsa-miR-30c hsa-miR-3671 hsa-miR-3607-3p hsa-miR-607 hsa-miR-30d hsa-miR-1297 hsa-miR-183* hsa-miR-656

		SwitchGear 3'UTR luciferase reporter plasmid: TANK 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TANK (see all 7) OriGene shRNA RFP: TANK OriGene siRNA: TANK
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TANK

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TANK (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TANK (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): TANK (NM_001199135)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TANK

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TANK

Additional cDNA sequence:

AK313096.1 BC003388.1 BC067779.1 BT009855.1 U59863.1 U63830.1

19 DOTS entries:

DT.91675628 DT.217271 DT.95275688 DT.91738433 DT.121025985 DT.100025328 DT.100782242 DT.92021857

DT.100659606 DT.100676521 DT.100782241 DT.101981250 DT.121025965 DT.40132141 DT.92024293 DT.96085145

DT.97763505 DT.40113470 DT.95295476

24/203 AceView cDNA sequences (see all 203):

T96025 NM_133484 BQ003880 NM_004180 AI090614 AL532012 AA134813 CR602454

AW950654 BC067779 R09657 AA633367 BX091561 BG565083 T30861 T36204

CR612977 AU279460 AA765575 BM680474 BU736055 AU139286 BC003388 BE138807

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TANK (see all 11) About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3	^	4a	·	4b	^	5	^	6	^	7a	·	7b	·	7c	·	7d	^	8	^	9a	·	9b	·	9c	^	10	^	11	^	12a	·	12b	^	13a	·	13b	·	13c	^	14	^
SP1:											-		-		-		-		-		-						-								-		-														-
SP2:					-		-		-		-		-		-		-		-		-						-								-		-														-
SP3:											-		-		-		-		-		-		-				-								-		-
SP4:																											-								-		-
SP5:											-		-		-		-		-		-						-

ExUns:	15a	·	15b
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for TANK

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TANK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGAAATTAA

About this image
See TANK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TANK

SOURCE GeneReport for Unigene cluster: Hs.132257

UniProtKB/Swiss-Prot: TANK_HUMAN, Q92844

Tissue specificity: Ubiquitous

SABiosciences Custom PCR Arrays for TANK

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TANK Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TANK

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TANK

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TANK gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tank^{1 , 5}	TRAF family member-associated Nf-kappa B activator^{1, 5}	86.52(n)¹ 82.08(a)¹		2 (35.56 cM)⁵ 21353¹ NM_011529.2¹ NP_035659.1¹ 61578585⁵
chicken (Gallus gallus)	Aves	TANK¹	TRAF family member-associated NFKB activator	64.35(n) 48.44(a)		424190 XM_422036.2 XP_422036.1
lizard (Anolis carolinensis)	Reptilia	TANK⁶	--	61(a)	1 ↔ 1	GL343371.1(91234-99494)
zebrafish (Danio rerio)	Actinopterygii	tank¹	TRAF family member-associated NFKB activator	47.28(n) 32.22(a)		767660 NM_001076600.1 NP_001070068.1

ENSEMBL Gene Tree for TANK (if available)
TreeFam Gene Tree for TANK (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3754978^1,2	C,F,A,H,	--	161991658(-)	`GGAGTC/TGTAAA`	2	--	us2k¹		12		EA NA NS WA	2402
rs189867316^1,2		--	161991683(+)	`GGTGGA/GGAGTA`	2	--	us2k¹		0	--	--	--	--
rs118101146^1,2		--	161991773(+)	`CTGGTT/CAGTGG`	2	--	us2k¹		1		EA	120
rs116894948^1,2	F,	--	161991842(+)	`TTCTCT/CGTTTT`	2	--	us2k¹		1		EA	120
rs148850460^1,2		--	161991850(+)	`TTTGGA/CTGTAG`	2	--	us2k¹		0	--	--	--	--
rs146994865^1,2		--	161991904(+)	`CCCTGC/GAGTAG`	2	--	us2k¹		0	--	--	--	--
rs979414^1,2	C,F,A,	--	161991924(+)	`CAGGAT/GCCTGG`	2	--	us2k¹ tfbs³		9		EA NA MN WA	1956
rs147617990^1,2		--	161991932(+)	`TGGGTA/GTCAGC`	2	--	us2k¹		0	--	--	--	--
rs182028206^1,2		--	161992022(+)	`AGACAA/GGAGCG`	2	--	us2k¹		0	--	--	--	--
rs79031205^1,2		--	161992207(+)	`ATATTC/TAGCAT`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TANK (161993419 - 162092732 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TANK
1 CNV: 1357

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TANK for disorders           About GeneDecksing

OMIM gene information: 603893    OMIM disorders: --

17 diseases for TANK:    About MalaCards

ellis-van creveld syndrome open-angle glaucoma monoclonal gammopathy of undetermined significance primary open angle glaucoma

non-hodgkin lymphoma glaucoma hodgkin's lymphoma multiple myeloma

rheumatoid arthritis hepatitis c myeloma cervical carcinoma

cervicitis arthritis astrocytoma hepatitis

carcinoma

4 Novoseek disease relationships for TANK gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	62.6	13	11112773 (1), 7859281 (1), 9153189 (1), 8702708 (1) (see all 13)
tumors	42.3	15	11112773 (1), 7859281 (1), 9153189 (1), 17633021 (1) (see all 13)
latent infection	34.9	1	11932422 (1)
hyperplasia	0	1	16888677 (1)

Human Genome Epidemiology (HuGE) Navigator: TANK (14 documents)

Export disorders for TANK gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TANK gene, integrated from 9 sources (see all 115):
(articles sorted by number of sources associating them with TANK)

Utopia: connect your pdf to the dynamic
world of online information

I-TRAF is a novel TRAF-interacting protein that regulates TRAF- mediated signal transduction. (PubMed id 8710854)^{1, 2, 3, 9} Rothe M....Goeddel D.V. (1996)
Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein. (PubMed id 8855313)^{1, 2, 3} Kaye K.M.... Mosialos G. (1996)
NF-kB activation by a signaling complex containing TRAF2, TANK, and TBK1, a novel IKK-related kinase. (PubMed id 10581243)^{1, 2, 9} Pomerantz J.L. and Baltimore D. (1999)
Downstream regulator TANK binds to the CD40 recognition site on TRAF3. (PubMed id 12005438)^{1, 2, 9} Li C.... Ely K.R. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases. (PubMed id 12133833)^{1, 2} Chariot A.... Siebenlist U. (2002)
NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation. (PubMed id 10759890)^{1, 2} Nomura F.... Akira S. (2000)
TANK potentiates tumor necrosis factor receptor-associated factor-mediated c-Jun N-terminal kinase/stress-activated protein kinase activation through the germinal center kinase pathway. (PubMed id 10490605)^{1, 9} Chin A.I....Cheng G. (1999)
TACI induces cIAP1-mediated ubiquitination of NIK by TRAF2 and TANK to limit non-canonical NF-kappaB signaling. (PubMed id 20184394)^{1, 9} Kanno Y....Kobata T. (2010)
Lipopolysaccharide-mediated interferon regulatory factor activation involves TBK1-IKKepsilon-dependent Lys(63)-linked polyubiquitination and phosphorylation of TANK/I-TRAF. (PubMed id 17823124)^{1, 9} Gatot J.S....Chariot A. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 10010	HGNC: 11562	AceView: TANK	Ensembl:ENSG00000136560	euGenes: HUgn10010
ECgene: TANK	Kegg: 10010	H-InvDB: TANK

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TANK	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TANK	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for TANK gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TANK gene:
Search GeneIP for patents involving TANK

GeneCards and IP:
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TRAF family member-associated NFKB activator

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