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TANK Gene

protein-coding   GIFtS: 63
GCID: GC02P161957

TRAF Family Member-Associated NFKB Activator


(Previous symbol: TRAF2)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TRAF Family Member-Associated NFKB Activator1 2
TRAF21 2 3
ITRAF2 3 5
I-TRAF2 3
TRAF-Interacting Protein2 3
TRAF Family Member-Associated NF-Kappa-B Activator2

External Ids:    HGNC: 115621   Entrez Gene: 100102   Ensembl: ENSG000001365607   OMIM: 6038935   UniProtKB: Q928443   

Export aliases for TANK gene to outside databases

Previous GC identifers: GC02P160047 GC02P160521 GC02P162196 GC02P161818 GC02P161701 GC02P153878


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TANK Gene:
The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce
signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found
in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the
TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding
to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three
alternatively spliced transcript variants encoding different isoforms have been found for this gene. (provided by
RefSeq, Nov 2010)

GeneCards Summary for TANK Gene:
TANK (TRAF family member-associated NFKB activator) is a protein-coding gene. GO annotations related to this gene include ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot: TANK_HUMAN, Q92844
Function: Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE
playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent
state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May control negatively
TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2

Gene Wiki entry for TANK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TANK gene promoter:
         SREBP-1a   deltaCREB   SREBP-1c   IRF-7A   NF-kappaB1   NF-kappaB   SREBP-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TANK promoter sequence
   Search Chromatin IP Primers for TANK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TANK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24-q31   Ensembl cytogenetic band:  2q24.2   HGNC cytogenetic band: 2q24-q31

TANK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TANK gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P161957:  view genomic region     (about GC identifiers)

Start:
161,993,419 bp from pter      End:
162,092,732 bp from pter
Size:
99,314 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TANK_HUMAN, Q92844 (See protein sequence)
Recommended Name: TRAF family member-associated NF-kappa-B activator  
Size: 425 amino acids; 47816 Da
Subunit: Homodimer. Interacts with TBK1 and IKBKE. Interacts also with TRAF1, TRAF2, and TRAF3 by binding to their
TRAF-C domains; the interaction with TRAF2 is disrupted by the phosphorylation of TANK by IKBKE. Interacts more
strongly with TRAF1 and TRAF2 than TRAF3. Interacts with IKBKG; the interaction is enhanced by IKBKE and TBK1.
Part of a ternary complex consisting of TANK, IKBKB and IKBKG
2 PDB 3D structures from and Proteopedia for TANK:
1KZZ (3D)        1L0A (3D)    
Secondary accessions: D3DPB5 Q7Z4J6 Q92885
Alternative splicing: 3 isoforms:  Q92844-1   Q92844-2   Q92844-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TANK: NX_Q92844

Explore proteomics data for TANK at MOPED

Post-translational modifications: 

  • Phosphorylated by IKBKE1
  • Ubiquitination2 at Lys86, Lys231, Lys371
  • Modification sites at PhosphoSitePlus

  • See TANK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_004171.2  NP_597841.1  NP_001186064.1  

    ENSEMBL proteins: 
     ENSP00000259075   ENSP00000398157   ENSP00000376505   ENSP00000399934   ENSP00000411041  
     ENSP00000384492   ENSP00000384235   ENSP00000388930   ENSP00000410259   ENSP00000412622  
     ENSP00000385487   ENSP00000392776   ENSP00000385983   ENSP00000412556   ENSP00000387439  
     ENSP00000415276  
    Reactome Protein details: Q92844

    TANK Human Recombinant Protein Products:

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    Novus Biologicals TANK Proteins
    Novus Biologicals TANK Lysates
    Browse Sino Biological Recombinant Proteins
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    ProSpec Recombinant Protein for TANK
    Cloud-Clone Corp. Proteins for TANK

     
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    LSBio Antibodies in human, mouse, rat for TANK

    TANK Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
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    Search eBioscience for ELISAs for TANK 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR024581 TBD

    Graphical View of Domain Structure for InterPro Entry Q92844

    ProtoNet protein and cluster: Q92844

    UniProtKB/Swiss-Prot: TANK_HUMAN, Q92844
    Similarity: Contains 1 C2H2-type zinc finger


    Find genes that share domains with TANK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TANK_HUMAN, Q92844
    Function: Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE
    playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent
    state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May control negatively
    TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2

         Genatlas biochemistry entry for TANK:
    tumor necrosis receptor-associated factor ,TRAF-interacting protein,mediator of NFKB activation after induction by
    TRAF2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12005438
    GO:0031625ubiquitin protein ligase binding IPI11279055
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with TANK           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TANK:
     Increased G1 DNA content 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tank):
     hematopoietic system  immune system  liver/biliary system  mortality/aging  renal/urinary system 
     respiratory system 

    Find genes that share phenotypes with TANK           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tanktm1Aki for TANK

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TANK
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TANK
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TANK

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TANK (see all 13):
    hsa-miR-30c hsa-miR-3671 hsa-miR-3607-3p hsa-miR-607 hsa-miR-30d hsa-miR-1297 hsa-miR-183* hsa-miR-656
    SwitchGear 3'UTR luciferase reporter plasmidTANK 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TANK

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    GenScript: all cDNA clones in your preferred vector (see all 3): TANK (NM_001199135)
    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TANK_HUMAN, Q92844: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with TANK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TANK About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
    TRAF6 mediated IRF7 activation0.40
    RIG-I-like receptor signaling pathway0.47
    2TWEAK Pathway
    TNFR1 Pathway0.56
    TNF Signaling0.55
    3TRAF Pathway
    TRAF Pathway0.42
    Toll-Like Receptors Pathway0.41
    4NOD-like Receptor Signaling Pathways
    Toll-Like receptor Signaling Pathways0.58
    54-1BB Pathway
    TNFR2 Pathway0.37


    Find genes that share SuperPaths with TANK           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TANK
        Toll-Like receptor Signaling Pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TANK
        TNF Signaling
    Toll-Like Receptors Pathway
    TRAF Pathway
    TNFR2 Pathway
    TNFR1 Pathway

    2 Cell Signaling Technology (CST) Pathways for TANK
        Apoptosis and Autophagy
    NF-kappaB Signaling

    1 BioSystems Pathway for TANK
        TNF-alpha/NF-kB Signaling Pathway

    1 Reactome Pathway for TANK
        TRAF6 mediated IRF7 activation


    1 Kegg Pathway  (Kegg details for TANK):
        RIG-I-like receptor signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TANK
    Interactions:

        GeneGlobe Interaction Network for TANK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TANK (Q928441, 2, 3 ENSP000002590754) via UniProtKB, MINT, STRING, and/or I2D (see all 77)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TBK1Q9UHD21, 2, 3, ENSP000003299674EBI-356349,EBI-356402 MINT-5114997 MINT-8144259 MINT-49268 MINT-49290 MINT-48040 MINT-6492446 MINT-8151323 MINT-48264 I2D: score=8 STRING: ENSP00000329967
    SUMO1P631651, 2, 3, ENSP000003760764EBI-356349,EBI-80140 MINT-8144259 MINT-8151307 MINT-8144047 MINT-8144064 MINT-8144154 MINT-8144012 MINT-8144107 MINT-8151323 I2D: score=1 STRING: ENSP00000376076
    ENSG00000206383P349312, 3MINT-48247 I2D: score=2 
    ENSG00000234258P349312, 3MINT-48247 I2D: score=2 
    ENSG00000236251P349312, 3MINT-48247 I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS8710854
    GO:0007249I-kappaB kinase/NF-kappaB signaling IEA--
    GO:0045087innate immune response TAS--

    Find genes that share ontologies with TANK           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TANK

    1 Novoseek inferred chemical compound relationship for TANK gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 13.1 5 15383523 (1), 8702708 (1), 16336209 (1), 8692885 (1)



    Find genes that share compounds with TANK           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TANK gene (3 alternative transcripts): 
    NM_004180.2  NM_133484.1  NM_001199135.1  

    Unigene Cluster for TANK:

    TRAF family member-associated NFKB activator
    Hs.132257  [show with all ESTs]
    Unigene Representative Sequence: NM_004180
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000259075(uc002ubr.2) ENST00000432002 ENST00000463502 ENST00000392749(uc002ubs.3)
    ENST00000440506 ENST00000461338 ENST00000429217 ENST00000406287 ENST00000402568
    ENST00000457887 ENST00000477952 ENST00000441987 ENST00000432692 ENST00000494976
    ENST00000405852 ENST00000483622 ENST00000456358 ENST00000468831
    miRNA
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    hsa-miR-30c hsa-miR-3671 hsa-miR-3607-3p hsa-miR-607 hsa-miR-30d hsa-miR-1297 hsa-miR-183* hsa-miR-656
    SwitchGear 3'UTR luciferase reporter plasmidTANK 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat TANK
      QuantiFast Probe-based Assays in human, mouse, rat TANK

    Additional mRNA sequence: 

    AK313096.1 BC003388.1 BC067779.1 BT009855.1 U59863.1 U63830.1 

    18 DOTS entries:

    DT.91675628  DT.217271  DT.95275688  DT.91738433  DT.121025985  DT.100025328  DT.100782242  DT.92021857 
    DT.100659606  DT.100782241  DT.101981250  DT.121025965  DT.40132141  DT.92024293  DT.96085145  DT.97763505 
    DT.40113470  DT.95295476 

    Selected AceView cDNA sequences (see all 203):

    BM680474 AW236447 AW950654 CF242863 BC003388 NM_133484 CB123528 BM718019 
    BG680246 T96025 AI289412 BQ003880 T30861 BU736055 BE138807 AL532012 
    AA134813 BG565083 AI090614 AU139286 BX436856 F04517 CR612977 BC067779 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TANK (see all 11)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^
    SP1:                                -     -     -     -     -     -                 -                       -     -                                         -   
    SP2:              -     -     -     -     -     -     -     -     -                 -                       -     -                                         -   
    SP3:                                -     -     -     -     -     -     -           -                       -     -                                             
    SP4:                                                                                -                       -     -                                             
    SP5:                                -     -     -     -     -     -                 -                                                                           

    ExUns: 15a · 15b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for TANK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    TANK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGAAATTAA
    TANK Expression
    About this image


    TANK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    TANK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TANK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.132257

    UniProtKB/Swiss-Prot: TANK_HUMAN, Q92844
    Tissue specificity: Ubiquitous

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TANK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TANK gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tank1 , 5 TRAF family member-associated Nf-kappa B activator1, 5 86.52(n)1
    82.08(a)1
      2 (35.56 cM)5
    213531  NM_011529.21  NP_035659.11 
     615785855 
    chicken
    (Gallus gallus)
    Aves TANK1 TRAF family member-associated NFKB activator 67.13(n)
    51.27(a)
      424190  NM_001277871.1  NP_001264800.1 
    lizard
    (Anolis carolinensis)
    Reptilia TANK6
    TRAF family member-associated NFKB activator
    40(a)
    1 ↔ 1
    GL343371.1(58837-123981)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tank1 TRAF family member-associated NFKB activator 53.43(n)
    40.59(a)
      100486218  XM_002933261.2  XP_002933307.2 
    zebrafish
    (Danio rerio)
    Actinopterygii tank1 TRAF family member-associated NFKB activator 48.38(n)
    33.33(a)
      767660  NM_001076600.1  NP_001070068.1 


    ENSEMBL Gene Tree for TANK (if available)
    TreeFam Gene Tree for TANK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TANK (see all 1546)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37549781,2
    C,F,A,H--161991658(-) GGAGTC/TGTAAA 2 -- us2k112Minor allele frequency- T:0.20EA NA NS WA 2402
    rs1898673161,2
    --161991683(+) GGTGGA/GGAGTA 2 -- us2k10--------
    rs1181011461,2
    F--161991773(+) CTGGTT/CAGTGG 2 -- us2k11Minor allele frequency- C:0.01EA 120
    rs1168949481,2
    C,F--161991842(+) TTCTCT/CGTTTT 2 -- us2k11Minor allele frequency- C:0.06EA 120
    rs1488504601,2
    --161991850(+) TTTGGA/CTGTAG 2 -- us2k10--------
    rs1469948651,2
    --161991904(+) CCCTGC/GAGTAG 2 -- us2k10--------
    rs9794141,2
    C,F,A--161991924(+) CAGGAT/GCCTGG 2 -- us2k1 tfbs39Minor allele frequency- G:0.20EA NA MN WA 1956
    rs1476179901,2
    --161991932(+) TGGGTA/GTCAGC 2 -- us2k10--------
    rs1820282061,2
    --161992022(+) AGACAA/GGAGCG 2 -- us2k10--------
    rs790312051,2
    C--161992207(+) ATATTC/TAGCAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TANK (161993419 - 162092732 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for TANK:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670224CNV Deletion23128226
    nsv3004CNV Insertion18451855
    nsv507044CNV Insertion20534489
    esv270537CNV Insertion20981092
    nsv459934CNV Loss19166990
    nsv437557CNV Loss16327808
    nsv834437CNV Gain17160897
    esv259615OTHER Complex20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TANK
    DNA2.0 Custom Variant and Variant Library Synthesis for TANK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603893    OMIM disorders: --


    Find genes that share disorders with TANK           About GenesLikeMe

    4 Novoseek inferred disease relationships for TANK gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 62.6 13 11112773 (1), 7859281 (1), 9153189 (1), 8702708 (1) (see all 13)
    tumors 42.3 15 11112773 (1), 7859281 (1), 9153189 (1), 17633021 (1) (see all 13)
    latent infection 34.9 1 11932422 (1)
    hyperplasia 0 1 16888677 (1)

    Genetic Association Database (GAD): TANK
    Human Genome Epidemiology (HuGE) Navigator: TANK (14 documents)

    Export disorders for TANK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TANK gene, integrated from 10 sources (see all 127):
    (articles sorted by number of sources associating them with TANK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. I-TRAF is a novel TRAF-interacting protein that regulates TRAF- mediated signal transduction. (PubMed id 8710854)1, 2, 3, 9 Rothe M....Goeddel D.V. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    2. Tumor necrosis factor receptor associated factor 2 is a mediator of NF-kappa B activation by latent infection membrane protein 1, the Epstein-Barr virus transforming protein. (PubMed id 8855313)1, 2, 3 Kaye K.M.... Mosialos G. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    3. NF-kB activation by a signaling complex containing TRAF2, TANK, and TBK1, a novel IKK-related kinase. (PubMed id 10581243)1, 2, 9 Pomerantz J.L. and Baltimore D. (EMBO J. 1999)
    4. Downstream regulator TANK binds to the CD40 recognition site on TRAF3. (PubMed id 12005438)1, 2, 9 Li C.... Ely K.R. (Structure 2002)
    5. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PubMed id 20331378)1, 4, 9 Mosbruger T.L....Thio C.L. (J. Infect. Dis. 2010)
    6. Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients. (PubMed id 19262425)1, 4, 9 Bowes J.D....Barton A. (Pharmacogenet. Genomics 2009)
    7. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (Am. J. Hematol. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    10. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10010 HGNC: 11562 AceView: TANK Ensembl:ENSG00000136560 euGenes: HUgn10010
    ECgene: TANK Kegg: 10010 H-InvDB: TANK

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TANK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TANK Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TANK gene:
    Search GeneIP for patents involving TANK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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