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Aliases for TANK Gene

Aliases for TANK Gene

  • TRAF Family Member Associated NFKB Activator 2 3 5
  • TRAF-Interacting Protein 3 4
  • I-TRAF 3 4
  • TRAF2 3 4
  • ITRAF 3 4
  • TRAF Family Member-Associated NF-Kappa-B Activator 3
  • TRAF Family Member-Associated NFKB Activator 2

External Ids for TANK Gene

Previous HGNC Symbols for TANK Gene

  • TRAF2

Previous GeneCards Identifiers for TANK Gene

  • GC02P160047
  • GC02P160521
  • GC02P161957
  • GC02P162196
  • GC02P161818
  • GC02P161701
  • GC02P153878

Summaries for TANK Gene

Entrez Gene Summary for TANK Gene

  • The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for TANK Gene

TANK (TRAF Family Member Associated NFKB Activator) is a Protein Coding gene. Among its related pathways are Immune System and Toll-Like receptor Signaling Pathways. GO annotations related to this gene include ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot for TANK Gene

  • Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.

Gene Wiki entry for TANK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TANK Gene

Genomics for TANK Gene

Regulatory Elements for TANK Gene

Enhancers for TANK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F161076 1.4 FANTOM5 Ensembl ENCODE 33 -59.1 -59108 2.8 PKNOX1 ATF1 TBL1XR1 BMI1 EGR1 CBX5 ETV6 CREM CBFB JUNB TANK LOC105373719 LINC01806 LOC100131736
GH02F161133 1.4 FANTOM5 ENCODE 27.7 +0.2 210 6.5 HDGF PKNOX1 ATF1 WRNIP1 FEZF1 SLC30A9 ZNF207 FOS SP5 JUNB LINC01806 TANK LOC105373719
GH02F161121 1.3 FANTOM5 Ensembl ENCODE 16.2 -13.3 -13255 4.7 PKNOX1 ZFP64 ARID4B FOS ZNF263 JUNB PPARG KAT8 SSRP1 MAFF TANK LOC105373719 LINC01806 LOC100131736
GH02F161067 0.7 FANTOM5 11.8 -69.0 -68971 0.2 TANK LOC105373719 LINC01806 LOC100131736
GH02F161102 0.5 Ensembl 11.5 -33.8 -33808 1.0 HLF CEBPB ZNF384 DPF2 TBX21 JUND CEBPA FOS TANK LOC105373719 LINC01806 LOC100131736
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TANK on UCSC Golden Path with GeneCards custom track

Promoters for TANK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000601290 1592 3801 HDGF TBP PKNOX1 ATF1 WRNIP1 DNMT3B ZBTB40 SLC30A9 ZNF207 CREM

Genomic Location for TANK Gene

Chromosome:
2
Start:
161,136,908 bp from pter
End:
161,236,221 bp from pter
Size:
99,314 bases
Orientation:
Plus strand

Genomic View for TANK Gene

Genes around TANK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TANK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TANK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TANK Gene

Proteins for TANK Gene

  • Protein details for TANK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92844-TANK_HUMAN
    Recommended name:
    TRAF family member-associated NF-kappa-B activator
    Protein Accession:
    Q92844
    Secondary Accessions:
    • D3DPB5
    • Q7Z4J6
    • Q92885

    Protein attributes for TANK Gene

    Size:
    425 amino acids
    Molecular mass:
    47816 Da
    Quaternary structure:
    • Homodimer. Found in a deubiquitination complex with TANK, USP10 and ZC3H12A; this complex inhibits genotoxic stress- or interleukin-1-beta-mediated NF-kappaB activation by promoting IKBKG or TRAF6 deubiquitination (PubMed:25861989). Interacts with IKBKG; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with TRAF6; this interaction increases in response to DNA damage and recruits USP10 to the ubiquitinated TRAF6 (PubMed:25861989). Interacts with USP10; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with ZC3H12A; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with TBK1 (PubMed:10581243, PubMed:21931631). Interacts with IKBKE (PubMed:17568778). Interacts also with TRAF1, TRAF2, and TRAF3 by binding to their TRAF-C domains; the interaction with TRAF2 is disrupted by the phosphorylation of TANK by IKBKE (PubMed:10759890, PubMed:12005438). Interacts more strongly with TRAF1 and TRAF2 than TRAF3 (PubMed:10759890, PubMed:12005438). Interacts with IKBKG; the interaction is enhanced by IKBKE and TBK1 (PubMed:12133833). Part of a ternary complex consisting of TANK, IKBKB and IKBKG (PubMed:12133833).

    Three dimensional structures from OCA and Proteopedia for TANK Gene

    Alternative splice isoforms for TANK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TANK Gene

Post-translational modifications for TANK Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TANK (TANK)

No data available for DME Specific Peptides for TANK Gene

Domains & Families for TANK Gene

Protein Domains for TANK Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TANK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92844

UniProtKB/Swiss-Prot:

TANK_HUMAN :
  • Contains 1 C2H2-type zinc finger.
Similarity:
  • Contains 1 C2H2-type zinc finger.
genes like me logo Genes that share domains with TANK: view

No data available for Gene Families for TANK Gene

Function for TANK Gene

Molecular function for TANK Gene

GENATLAS Biochemistry:
tumor necrosis receptor-associated factor ,TRAF-interacting protein,mediator of NFKB activation after induction by TRAF2
UniProtKB/Swiss-Prot Function:
Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.

Gene Ontology (GO) - Molecular Function for TANK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 contributes_to thiol-dependent ubiquitin-specific protease activity IMP 25861989
GO:0005515 protein binding IPI 12005438
GO:0031625 ubiquitin protein ligase binding IPI 11279055
GO:0035800 deubiquitinase activator activity IMP 25861989
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TANK: view
genes like me logo Genes that share phenotypes with TANK: view

Animal Models for TANK Gene

MGI Knock Outs for TANK:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TANK Gene

Localization for TANK Gene

Subcellular locations from UniProtKB/Swiss-Prot for TANK Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TANK Gene COMPARTMENTS Subcellular localization image for TANK gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 2

Gene Ontology (GO) - Cellular Components for TANK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0043234 protein complex IDA 25861989
genes like me logo Genes that share ontologies with TANK: view

Pathways & Interactions for TANK Gene

genes like me logo Genes that share pathways with TANK: view

Pathways by source for TANK Gene

Gene Ontology (GO) - Biological Process for TANK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006974 cellular response to DNA damage stimulus IMP 25861989
GO:0007165 signal transduction TAS 8710854
GO:0007249 I-kappaB kinase/NF-kappaB signaling IBA --
GO:0035666 TRIF-dependent toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with TANK: view

No data available for SIGNOR curated interactions for TANK Gene

Drugs & Compounds for TANK Gene

(1) Drugs for TANK Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TANK: view

Transcripts for TANK Gene

Unigene Clusters for TANK Gene

TRAF family member-associated NFKB activator:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TANK Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - -
SP8:
SP9:
SP10:
SP11: - - - - - - - - -

ExUns: 15a · 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for TANK Gene

GeneLoc Exon Structure for
TANK
ECgene alternative splicing isoforms for
TANK

Expression for TANK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TANK Gene

Protein differential expression in normal tissues from HIPED for TANK Gene

This gene is overexpressed in Breast (56.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TANK Gene



Protein tissue co-expression partners for TANK Gene

NURSA nuclear receptor signaling pathways regulating expression of TANK Gene:

TANK

SOURCE GeneReport for Unigene cluster for TANK Gene:

Hs.132257

mRNA Expression by UniProt/SwissProt for TANK Gene:

Q92844-TANK_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with TANK: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TANK Gene

Orthologs for TANK Gene

This gene was present in the common ancestor of chordates.

Orthologs for TANK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TANK 34 35
  • 99.53 (n)
cow
(Bos Taurus)
Mammalia TANK 34 35
  • 91.55 (n)
dog
(Canis familiaris)
Mammalia TANK 34 35
  • 90.12 (n)
rat
(Rattus norvegicus)
Mammalia Tank 34
  • 87.01 (n)
mouse
(Mus musculus)
Mammalia Tank 34 16 35
  • 86.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 63 (a)
OneToMany
-- 35
  • 52 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia TANK 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves TANK 34 35
  • 67.13 (n)
lizard
(Anolis carolinensis)
Reptilia TANK 35
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tank 34
  • 53.43 (n)
zebrafish
(Danio rerio)
Actinopterygii tank 34 35
  • 48.38 (n)
Species where no ortholog for TANK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TANK Gene

ENSEMBL:
Gene Tree for TANK (if available)
TreeFam:
Gene Tree for TANK (if available)

Paralogs for TANK Gene

No data available for Paralogs for TANK Gene

Variants for TANK Gene

Sequence variations from dbSNP and Humsavar for TANK Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10166292 -- 161,233,168(+) TGATT(A/G)AGCCT intron-variant
rs10166550 -- 161,143,083(+) gtagc(A/T)attgt intron-variant
rs10174160 -- 161,138,666(+) GCCTT(C/G)AGGTT intron-variant
rs10175805 -- 161,151,209(+) cctgg(A/G)gaaga intron-variant
rs10178063 -- 161,217,307(+) aactc(A/G)gaatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TANK Gene

Variant ID Type Subtype PubMed ID
dgv7140n54 CNV loss 21841781
esv2670224 CNV deletion 23128226
esv3302641 CNV tandem duplication 20981092
esv3306260 CNV mobile element insertion 20981092
esv3323881 CNV duplication 20981092
esv3378589 CNV insertion 20981092
esv3446273 CNV insertion 20981092
esv3593151 CNV loss 21293372
nsv1117263 CNV tandem duplication 24896259
nsv3004 CNV insertion 18451855
nsv437557 CNV loss 16327808
nsv459934 CNV loss 19166990
nsv475536 CNV novel sequence insertion 20440878
nsv478156 CNV novel sequence insertion 20440878
nsv478892 CNV novel sequence insertion 20440878
nsv507044 OTHER sequence alteration 20534489
nsv583500 CNV loss 21841781
nsv834437 CNV gain 17160897
nsv955276 CNV duplication 24416366

Variation tolerance for TANK Gene

Residual Variation Intolerance Score: 89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.92; 67.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TANK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TANK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TANK Gene

Disorders for TANK Gene

Relevant External Links for TANK

Genetic Association Database (GAD)
TANK
Human Genome Epidemiology (HuGE) Navigator
TANK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TANK

No disorders were found for TANK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TANK Gene

Publications for TANK Gene

  1. I-TRAF is a novel TRAF-interacting protein that regulates TRAF- mediated signal transduction. (PMID: 8710854) Rothe M. … Goeddel D.V. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 22 64
  2. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger T.L. … Thio C.L. (J. Infect. Dis. 2010) 3 22 46 64
  3. Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients. (PMID: 19262425) Bowes J.D. … Barton A. (Pharmacogenet. Genomics 2009) 3 22 46 64
  4. Downstream regulator TANK binds to the CD40 recognition site on TRAF3. (PMID: 12005438) Li C. … Ely K.R. (Structure 2002) 3 4 22 64
  5. NF-kB activation by a signaling complex containing TRAF2, TANK, and TBK1, a novel IKK-related kinase. (PMID: 10581243) Pomerantz J.L. … Baltimore D. (EMBO J. 1999) 3 4 22 64

Products for TANK Gene

Sources for TANK Gene

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