Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TANK Gene

Aliases for TANK Gene

  • TRAF Family Member Associated NFKB Activator 2 3 5
  • TRAF-Interacting Protein 3 4
  • I-TRAF 3 4
  • TRAF2 3 4
  • ITRAF 3 4
  • TRAF Family Member-Associated NF-Kappa-B Activator 3
  • TRAF Family Member-Associated NFKB Activator 2

External Ids for TANK Gene

Previous HGNC Symbols for TANK Gene

  • TRAF2

Previous GeneCards Identifiers for TANK Gene

  • GC02P160047
  • GC02P160521
  • GC02P161957
  • GC02P162196
  • GC02P161818
  • GC02P161701
  • GC02P153878

Summaries for TANK Gene

Entrez Gene Summary for TANK Gene

  • The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GeneCards Summary for TANK Gene

TANK (TRAF Family Member Associated NFKB Activator) is a Protein Coding gene. Diseases associated with TANK include Vaccinia. Among its related pathways are TNFR1 Pathway and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. GO annotations related to this gene include ubiquitin protein ligase binding.

UniProtKB/Swiss-Prot for TANK Gene

  • Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.

Gene Wiki entry for TANK Gene

Additional gene information for TANK Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TANK Gene

Genomics for TANK Gene

Regulatory Elements for TANK Gene

Enhancers for TANK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H161076 1.5 FANTOM5 Ensembl ENCODE 33 -59.1 -59122 2 PKNOX1 ATF1 TBL1XR1 BMI1 BATF ZNF766 ATF7 ETV6 RUNX3 IKZF2 TANK LOC105373719 LINC01806 LOC100131736
GH02H161133 1.5 FANTOM5 ENCODE dbSUPER 27.7 +0.2 210 6 HDGF PKNOX1 FOXA2 NFIB FEZF1 BATF DNMT3B ZSCAN9 ZNF207 ATF7 LINC01806 TANK LOC105373719
GH02H161121 1.8 FANTOM5 Ensembl ENCODE dbSUPER 16.2 -13.3 -13255 4 PKNOX1 FOXA2 ZFP64 ARID4B FOS ZHX2 JUNB PPARG KAT8 NFIL3 TANK LOC105373719 LINC01806 LOC100131736
GH02H161088 1 Ensembl ENCODE 11.5 -47.1 -47099 2 HDGF FOXA2 TBL1XR1 RB1 BMI1 EBF1 BATF RELA RFX5 POLR2A TANK LOC105373719 LINC01806 LOC100131736
GH02H161063 1.1 Ensembl ENCODE 10.4 -73.3 -73255 1 ELF3 CTCF RB1 SAP130 RAD21 TEAD3 SLC30A9 SCRT2 SMC3 ZNF143 TANK LOC105373719 LINC01806 LOC100131736
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TANK on UCSC Golden Path with GeneCards custom track

Promoters for TANK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000294395 692 1601 HDGF PKNOX1 RELA POLR2A EED ZNF207 ATF7 PRDM10 IKZF2 CREM

Genomic Location for TANK Gene

Chromosome:
2
Start:
161,136,908 bp from pter
End:
161,236,221 bp from pter
Size:
99,314 bases
Orientation:
Plus strand

Genomic View for TANK Gene

Genes around TANK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TANK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TANK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TANK Gene

Proteins for TANK Gene

  • Protein details for TANK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92844-TANK_HUMAN
    Recommended name:
    TRAF family member-associated NF-kappa-B activator
    Protein Accession:
    Q92844
    Secondary Accessions:
    • D3DPB5
    • Q7Z4J6
    • Q92885

    Protein attributes for TANK Gene

    Size:
    425 amino acids
    Molecular mass:
    47816 Da
    Quaternary structure:
    • Homodimer. Found in a deubiquitination complex with TANK, USP10 and ZC3H12A; this complex inhibits genotoxic stress- or interleukin-1-beta-mediated NF-kappaB activation by promoting IKBKG or TRAF6 deubiquitination (PubMed:25861989). Interacts with IKBKG; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with TRAF6; this interaction increases in response to DNA damage and recruits USP10 to the ubiquitinated TRAF6 (PubMed:25861989). Interacts with USP10; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with ZC3H12A; this interaction increases in response to DNA damage (PubMed:25861989). Interacts with TBK1 (PubMed:10581243, PubMed:21931631). Interacts with IKBKE (PubMed:17568778). Interacts also with TRAF1, TRAF2, and TRAF3 by binding to their TRAF-C domains; the interaction with TRAF2 is disrupted by the phosphorylation of TANK by IKBKE (PubMed:10759890, PubMed:12005438). Interacts more strongly with TRAF1 and TRAF2 than TRAF3 (PubMed:10759890, PubMed:12005438). Interacts with IKBKG; the interaction is enhanced by IKBKE and TBK1 (PubMed:12133833). Part of a ternary complex consisting of TANK, IKBKB and IKBKG (PubMed:12133833).
    • (Microbial infection) Interacts with vaccinia virus protein C6 (PubMed:21931555).

    Three dimensional structures from OCA and Proteopedia for TANK Gene

    Alternative splice isoforms for TANK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TANK Gene

Post-translational modifications for TANK Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TANK (TANK)

No data available for DME Specific Peptides for TANK Gene

Domains & Families for TANK Gene

Gene Families for TANK Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TANK Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TANK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TANK: view

No data available for UniProtKB/Swiss-Prot for TANK Gene

Function for TANK Gene

Molecular function for TANK Gene

GENATLAS Biochemistry:
tumor necrosis receptor-associated factor ,TRAF-interacting protein,mediator of NFKB activation after induction by TRAF2
UniProtKB/Swiss-Prot Function:
Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.

Phenotypes From GWAS Catalog for TANK Gene

Gene Ontology (GO) - Molecular Function for TANK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004843 contributes_to thiol-dependent ubiquitin-specific protease activity IMP 25861989
GO:0005515 protein binding IPI 12005438
GO:0031625 ubiquitin protein ligase binding IPI 11279055
GO:0035800 deubiquitinase activator activity IMP 25861989
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TANK: view
genes like me logo Genes that share phenotypes with TANK: view

Animal Models for TANK Gene

MGI Knock Outs for TANK:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TANK
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TANK Gene

Localization for TANK Gene

Subcellular locations from UniProtKB/Swiss-Prot for TANK Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TANK gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TANK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0043234 protein complex IDA 25861989
genes like me logo Genes that share ontologies with TANK: view

Pathways & Interactions for TANK Gene

genes like me logo Genes that share pathways with TANK: view

Gene Ontology (GO) - Biological Process for TANK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0006974 cellular response to DNA damage stimulus IMP 25861989
GO:0007165 signal transduction TAS 8710854
GO:0007249 I-kappaB kinase/NF-kappaB signaling IEA --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with TANK: view

No data available for SIGNOR curated interactions for TANK Gene

Drugs & Compounds for TANK Gene

(1) Drugs for TANK Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TANK: view

Transcripts for TANK Gene

Unigene Clusters for TANK Gene

TRAF family member-associated NFKB activator:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TANK
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TANK Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^
SP1: - - - - - - - - - -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - -
SP5: - - - - - - -
SP6: - - - - - - -
SP7: - -
SP8:
SP9:
SP10:
SP11: - - - - - - - - -

ExUns: 15a · 15b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for TANK Gene

GeneLoc Exon Structure for
TANK
ECgene alternative splicing isoforms for
TANK

Expression for TANK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TANK Gene

Protein differential expression in normal tissues from HIPED for TANK Gene

This gene is overexpressed in Breast (56.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TANK Gene



Protein tissue co-expression partners for TANK Gene

NURSA nuclear receptor signaling pathways regulating expression of TANK Gene:

TANK

SOURCE GeneReport for Unigene cluster for TANK Gene:

Hs.132257

mRNA Expression by UniProt/SwissProt for TANK Gene:

Q92844-TANK_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for TANK Gene

  • Spleen(4.4)
  • Liver(4.3)
  • Blood(2.5)
  • Nervous system(2.4)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with TANK: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TANK Gene

Orthologs for TANK Gene

This gene was present in the common ancestor of chordates.

Orthologs for TANK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TANK 33 34
  • 99.53 (n)
cow
(Bos Taurus)
Mammalia TANK 33 34
  • 91.55 (n)
dog
(Canis familiaris)
Mammalia TANK 33 34
  • 90.12 (n)
rat
(Rattus norvegicus)
Mammalia Tank 33
  • 87.01 (n)
mouse
(Mus musculus)
Mammalia Tank 33 16 34
  • 86.52 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 63 (a)
OneToMany
-- 34
  • 52 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia TANK 34
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves TANK 33 34
  • 67.13 (n)
lizard
(Anolis carolinensis)
Reptilia TANK 34
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tank 33
  • 53.43 (n)
zebrafish
(Danio rerio)
Actinopterygii tank 33 34
  • 48.38 (n)
Species where no ortholog for TANK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TANK Gene

ENSEMBL:
Gene Tree for TANK (if available)
TreeFam:
Gene Tree for TANK (if available)

Paralogs for TANK Gene

No data available for Paralogs for TANK Gene

Variants for TANK Gene

Sequence variations from dbSNP and Humsavar for TANK Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000000781 -- 161,154,844(+) GGTGC(A/G)AATGA intron-variant
rs1000017619 -- 161,177,462(+) AAATA(A/G)TGCCA intron-variant
rs1000024096 -- 161,175,221(+) TTGGC(A/G)CTAAA intron-variant
rs1000049075 -- 161,160,859(+) ACTTC(C/G)CTTCG intron-variant, upstream-variant-2KB
rs1000096892 -- 161,167,135(+) AAATT(A/G)CTCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TANK Gene

Variant ID Type Subtype PubMed ID
dgv7140n54 CNV loss 21841781
esv2670224 CNV deletion 23128226
esv3302641 CNV tandem duplication 20981092
esv3306260 CNV mobile element insertion 20981092
esv3323881 CNV duplication 20981092
esv3378589 CNV insertion 20981092
esv3446273 CNV insertion 20981092
esv3593151 CNV loss 21293372
nsv1117263 CNV tandem duplication 24896259
nsv3004 CNV insertion 18451855
nsv437557 CNV loss 16327808
nsv459934 CNV loss 19166990
nsv475536 CNV novel sequence insertion 20440878
nsv478156 CNV novel sequence insertion 20440878
nsv478892 CNV novel sequence insertion 20440878
nsv507044 OTHER sequence alteration 20534489
nsv583500 CNV loss 21841781
nsv834437 CNV gain 17160897
nsv955276 CNV duplication 24416366

Variation tolerance for TANK Gene

Residual Variation Intolerance Score: 89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.92; 67.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TANK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TANK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TANK Gene

Disorders for TANK Gene

MalaCards: The human disease database

(1) MalaCards diseases for TANK Gene - From: GeneCards

Disorder Aliases PubMed IDs
vaccinia
- elite association - COSMIC cancer census association via MalaCards
Search TANK in MalaCards View complete list of genes associated with diseases

Relevant External Links for TANK

Genetic Association Database (GAD)
TANK
Human Genome Epidemiology (HuGE) Navigator
TANK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TANK
genes like me logo Genes that share disorders with TANK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TANK Gene

Publications for TANK Gene

  1. I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. (PMID: 8710854) Rothe M … Goeddel DV (Proceedings of the National Academy of Sciences of the United States of America 1996) 2 3 4 22 60
  2. Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. (PMID: 20331378) Mosbruger TL … Thio CL (The Journal of infectious diseases 2010) 3 22 45 60
  3. Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients. (PMID: 19262425) Bowes JD … BRAGGSS (Pharmacogenetics and genomics 2009) 3 22 45 60
  4. Downstream regulator TANK binds to the CD40 recognition site on TRAF3. (PMID: 12005438) Li C … Ely KR (Structure (London, England : 1993) 2002) 3 4 22 60
  5. NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase. (PMID: 10581243) Pomerantz JL … Baltimore D (The EMBO journal 1999) 3 4 22 60

Products for TANK Gene

Sources for TANK Gene

Content
Loading form....