Aliases for TANK Gene
External Ids for TANK Gene
Previous HGNC Symbols for TANK Gene
Previous GeneCards Identifiers for TANK Gene
The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
GeneCards Summary for TANK Gene
TANK (TRAF Family Member Associated NFKB Activator) is a Protein Coding gene. Among its related pathways are MyD88 cascade initiated on plasma membrane and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. GO annotations related to this gene include ubiquitin protein ligase binding.
UniProtKB/Swiss-Prot for TANK Gene
Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.