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Aliases for TANGO6 Gene

Aliases for TANGO6 Gene

  • Transport And Golgi Organization 6 Homolog 2 3 5
  • Transmembrane And Coiled-Coil Domain-Containing Protein 7 3 4
  • Transmembrane And Coiled-Coil Domains 7 2 3
  • TMCO7 3 4
  • Transport And Golgi Organization 6 Homolog (Drosophila) 2
  • KIAA1746 4

External Ids for TANGO6 Gene

Previous HGNC Symbols for TANGO6 Gene

  • TMCO7

Previous GeneCards Identifiers for TANGO6 Gene

  • GC16P068878

Summaries for TANGO6 Gene

GeneCards Summary for TANGO6 Gene

TANGO6 (Transport And Golgi Organization 6 Homolog) is a Protein Coding gene. GO annotations related to this gene include binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TANGO6 Gene

Genomics for TANGO6 Gene

Regulatory Elements for TANGO6 Gene

Enhancers for TANGO6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TANGO6 on UCSC Golden Path with GeneCards custom track

Promoters for TANGO6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TANGO6 on UCSC Golden Path with GeneCards custom track

Genomic Location for TANGO6 Gene

Chromosome:
16
Start:
68,843,553 bp from pter
End:
69,085,182 bp from pter
Size:
241,630 bases
Orientation:
Plus strand

Genomic View for TANGO6 Gene

Genes around TANGO6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TANGO6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TANGO6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TANGO6 Gene

Proteins for TANGO6 Gene

  • Protein details for TANGO6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0B7-TNG6_HUMAN
    Recommended name:
    Transport and Golgi organization protein 6 homolog
    Protein Accession:
    Q9C0B7
    Secondary Accessions:
    • Q569F9
    • Q9H9K1

    Protein attributes for TANGO6 Gene

    Size:
    1094 amino acids
    Molecular mass:
    120748 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14224.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB21837.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for TANGO6 Gene

Proteomics data for TANGO6 Gene at MOPED

Post-translational modifications for TANGO6 Gene

  • Ubiquitination at Lys 387
  • Modification sites at PhosphoSitePlus

Other Protein References for TANGO6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TANGO6 Gene

Domains & Families for TANGO6 Gene

Protein Domains for TANGO6 Gene

Suggested Antigen Peptide Sequences for TANGO6 Gene

Graphical View of Domain Structure for InterPro Entry

Q9C0B7

UniProtKB/Swiss-Prot:

TNG6_HUMAN :
  • Belongs to the Tango6 family.
  • Contains 2 HEAT repeats.
Family:
  • Belongs to the Tango6 family.
Similarity:
  • Contains 2 HEAT repeats.
genes like me logo Genes that share domains with TANGO6: view

No data available for Gene Families for TANGO6 Gene

Function for TANGO6 Gene

Phenotypes for TANGO6 Gene

genes like me logo Genes that share phenotypes with TANGO6: view

Animal Models for TANGO6 Gene

MGI Knock Outs for TANGO6:

Animal Model Products

CRISPR Products

miRNA for TANGO6 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TANGO6 Gene

Localization for TANGO6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TANGO6 Gene

Membrane; Single-pass membrane protein.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TANGO6 Gene

Pathways & Interactions for TANGO6 Gene

SuperPathways for TANGO6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TANGO6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TANGO6 Gene

Drugs & Compounds for TANGO6 Gene

No Compound Related Data Available

Transcripts for TANGO6 Gene

mRNA/cDNA for TANGO6 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TANGO6 Gene

Transport and golgi organization 6 homolog (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TANGO6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b ^
SP1: - - - - -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:

ExUns: 18 ^ 19a · 19b · 19c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for TANGO6 Gene

GeneLoc Exon Structure for
TANGO6
ECgene alternative splicing isoforms for
TANGO6

Expression for TANGO6 Gene

mRNA expression in normal human tissues for TANGO6 Gene

Protein differential expression in normal tissues from HIPED for TANGO6 Gene

This gene is overexpressed in Pancreas (39.9) and Lung (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TANGO6 Gene



SOURCE GeneReport for Unigene cluster for TANGO6 Gene Hs.13526

genes like me logo Genes that share expression patterns with TANGO6: view

Protein tissue co-expression partners for TANGO6 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TANGO6 Gene

Orthologs for TANGO6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TANGO6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TANGO6 35
  • 86.7 (n)
  • 87.48 (a)
TANGO6 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TANGO6 35
  • 86.93 (n)
  • 86.41 (a)
TANGO6 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tango6 35
  • 83.6 (n)
  • 83.44 (a)
Tango6 16
Tango6 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMCO7 35
  • 99.42 (n)
  • 99.27 (a)
TANGO6 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tango6 35
  • 83.95 (n)
  • 83.36 (a)
oppossum
(Monodelphis domestica)
Mammalia TANGO6 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TANGO6 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves TANGO6 35
  • 67.01 (n)
  • 63.92 (a)
-- 36
  • 73 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia TANGO6 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tango6 35
  • 59.67 (n)
  • 57.24 (a)
zebrafish
(Danio rerio)
Actinopterygii tango6 35
  • 54.9 (n)
  • 50.59 (a)
tango6 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Tango6 36
  • 19 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ekl-6 36
  • 16 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 17 (a)
OneToOne
RTP1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToOne
Species with no ortholog for TANGO6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TANGO6 Gene

ENSEMBL:
Gene Tree for TANGO6 (if available)
TreeFam:
Gene Tree for TANGO6 (if available)

Paralogs for TANGO6 Gene

No data available for Paralogs for TANGO6 Gene

Variants for TANGO6 Gene

Sequence variations from dbSNP and Humsavar for TANGO6 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3885991 -- 68,996,907(+) AAATT(C/T)AAAGA intron-variant
rs28142 -- 68,990,487(+) gctcc(A/G)tccca intron-variant
rs28143 -- 68,996,741(+) TTGAC(C/G)ATTTT intron-variant
rs3980015 -- 69,020,901(-) ACACA(-/CACACACATACA)TACAT intron-variant
rs32853 -- 69,033,635(+) CTTCC(C/T)TTCTG intron-variant

Variation tolerance for TANGO6 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.47; 64.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TANGO6 Gene

HapMap Linkage Disequilibrium report
TANGO6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TANGO6 Gene

Disorders for TANGO6 Gene

Relevant External Links for TANGO6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TANGO6

No disorders were found for TANGO6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TANGO6 Gene

Publications for TANGO6 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. (PMID: 12421765) Nakayama M. … Ohara O. (Genome Res. 2002) 3

Products for TANGO6 Gene

Sources for TANGO6 Gene

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