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Aliases for TANGO6 Gene

Aliases for TANGO6 Gene

  • Transport And Golgi Organization 6 Homolog 2 3 5
  • Transmembrane And Coiled-Coil Domain-Containing Protein 7 3 4
  • Transmembrane And Coiled-Coil Domains 7 2 3
  • TMCO7 3 4
  • Transport And Golgi Organization 6 Homolog (Drosophila) 2
  • Transport And Golgi Organization Protein 6 Homolog 3
  • KIAA1746 4

External Ids for TANGO6 Gene

Previous HGNC Symbols for TANGO6 Gene

  • TMCO7

Previous GeneCards Identifiers for TANGO6 Gene

  • GC16P068878

Summaries for TANGO6 Gene

GeneCards Summary for TANGO6 Gene

TANGO6 (Transport And Golgi Organization 6 Homolog) is a Protein Coding gene. GO annotations related to this gene include binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TANGO6 Gene

Genomics for TANGO6 Gene

Regulatory Elements for TANGO6 Gene

Enhancers for TANGO6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F068785 1.1 Ensembl ENCODE 11.9 -56.7 -56741 1.8 ELF3 ARID4B DMAP1 ZSCAN9 RAD21 DNMT3B RARA YY1 CREM THAP11 ZFP90 TANGO6 CDH1 RNU4-36P ENSG00000252040 ENSG00000252640 FTLP14 GC16P068743 RNA5SP429
GH16F068759 1.6 FANTOM5 Ensembl ENCODE 4.7 -81.0 -80956 7.0 HDGF PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 ZNF48 YY1 ELK1 DPEP2 ZFP90 CDH1 PRMT7 TANGO6 THAP11 CYB5B GC16P068743 RNA5SP429 FTLP14
GH16F068846 1.1 Ensembl ENCODE 6 +3.9 3927 1.0 HDGF SOX13 ELF3 DRAP1 CTCF ZNF792 JUN RAD21 RARA ZNF143 FTLP14 TANGO6 GC16P068850
GH16F068842 1.1 ENCODE 5.7 +0.3 344 1.9 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207 NONOP1 PSKH1 CHTF8 SLC7A6OS ENSG00000263276 CENPT TANGO6 GC16P068850
GH16F068972 1 Ensembl ENCODE 5.9 +129.5 129523 1.5 CTCF ETV1 MAX RAD21 GATA3 CTBP1 POLR2A SMC3 FOS REST CDH1 TANGO6 ENSG00000260999 GC16M069007
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TANGO6 on UCSC Golden Path with GeneCards custom track

Promoters for TANGO6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001506122 348 1799 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ZNF207

Genomic Location for TANGO6 Gene

Chromosome:
16
Start:
68,843,553 bp from pter
End:
69,085,182 bp from pter
Size:
241,630 bases
Orientation:
Plus strand

Genomic View for TANGO6 Gene

Genes around TANGO6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TANGO6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TANGO6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TANGO6 Gene

Proteins for TANGO6 Gene

  • Protein details for TANGO6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0B7-TNG6_HUMAN
    Recommended name:
    Transport and Golgi organization protein 6 homolog
    Protein Accession:
    Q9C0B7
    Secondary Accessions:
    • Q569F9
    • Q9H9K1

    Protein attributes for TANGO6 Gene

    Size:
    1094 amino acids
    Molecular mass:
    120748 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14224.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB21837.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for TANGO6 Gene

Post-translational modifications for TANGO6 Gene

  • Ubiquitination at Lys 387
  • Modification sites at PhosphoSitePlus

Other Protein References for TANGO6 Gene

No data available for DME Specific Peptides for TANGO6 Gene

Domains & Families for TANGO6 Gene

Protein Domains for TANGO6 Gene

Suggested Antigen Peptide Sequences for TANGO6 Gene

Graphical View of Domain Structure for InterPro Entry

Q9C0B7

UniProtKB/Swiss-Prot:

TNG6_HUMAN :
  • Belongs to the Tango6 family.
  • Contains 2 HEAT repeats.
Family:
  • Belongs to the Tango6 family.
Similarity:
  • Contains 2 HEAT repeats.
genes like me logo Genes that share domains with TANGO6: view

No data available for Gene Families for TANGO6 Gene

Function for TANGO6 Gene

Phenotypes for TANGO6 Gene

genes like me logo Genes that share phenotypes with TANGO6: view

Animal Models for TANGO6 Gene

MGI Knock Outs for TANGO6:

Animal Model Products

miRNA for TANGO6 Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TANGO6 Gene

Localization for TANGO6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TANGO6 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TANGO6 gene
Compartment Confidence
plasma membrane 2
cytosol 2
golgi apparatus 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TANGO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TANGO6: view

Pathways & Interactions for TANGO6 Gene

SuperPathways for TANGO6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TANGO6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TANGO6 Gene

Transcripts for TANGO6 Gene

mRNA/cDNA for TANGO6 Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TANGO6 Gene

Transport and golgi organization 6 homolog (Drosophila):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TANGO6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b ^
SP1: - - - - -
SP2:
SP3: -
SP4:
SP5:
SP6:
SP7:

ExUns: 18 ^ 19a · 19b · 19c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for TANGO6 Gene

GeneLoc Exon Structure for
TANGO6
ECgene alternative splicing isoforms for
TANGO6

Expression for TANGO6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TANGO6 Gene

Protein differential expression in normal tissues from HIPED for TANGO6 Gene

This gene is overexpressed in Pancreas (39.9) and Lung (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TANGO6 Gene



Protein tissue co-expression partners for TANGO6 Gene

NURSA nuclear receptor signaling pathways regulating expression of TANGO6 Gene:

TANGO6

SOURCE GeneReport for Unigene cluster for TANGO6 Gene:

Hs.13526
genes like me logo Genes that share expression patterns with TANGO6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TANGO6 Gene

Orthologs for TANGO6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TANGO6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMCO7 34
  • 99.42 (n)
TANGO6 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TANGO6 34 35
  • 86.93 (n)
cow
(Bos Taurus)
Mammalia TANGO6 34 35
  • 86.7 (n)
rat
(Rattus norvegicus)
Mammalia Tango6 34
  • 83.95 (n)
mouse
(Mus musculus)
Mammalia Tango6 34 16 35
  • 83.6 (n)
oppossum
(Monodelphis domestica)
Mammalia TANGO6 35
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TANGO6 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 73 (a)
OneToMany
TANGO6 34
  • 67.01 (n)
-- 35
  • 60 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia TANGO6 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tango6 34
  • 59.67 (n)
zebrafish
(Danio rerio)
Actinopterygii tango6 34 35
  • 54.9 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tango6 35
  • 19 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ekl-6 35
  • 16 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 17 (a)
OneToOne
RTP1 37
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
OneToOne
Species where no ortholog for TANGO6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TANGO6 Gene

ENSEMBL:
Gene Tree for TANGO6 (if available)
TreeFam:
Gene Tree for TANGO6 (if available)

Paralogs for TANGO6 Gene

No data available for Paralogs for TANGO6 Gene

Variants for TANGO6 Gene

Sequence variations from dbSNP and Humsavar for TANGO6 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10083737 -- 68,962,803(+) GCggc(C/T)gggcg intron-variant
rs10454704 -- 69,063,668(+) AAAAA(A/C)AACAA intron-variant
rs10500546 -- 68,922,722(+) AAAGC(A/G)CGAGG intron-variant
rs10500547 -- 68,927,079(+) TTCTC(C/T)GTGAT intron-variant
rs10687062 -- 69,072,154(+) TGTGT(-/GT)CACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TANGO6 Gene

Variant ID Type Subtype PubMed ID
esv2595638 CNV deletion 19546169
nsv833268 CNV loss 17160897
nsv827714 CNV loss 20364138
nsv827713 CNV loss 20364138
nsv572910 CNV loss 21841781
nsv572908 CNV gain 21841781
nsv475449 CNV novel sequence insertion 20440878
nsv474806 CNV novel sequence insertion 20440878
nsv457515 CNV gain 19166990
nsv1113818 CNV deletion 24896259
esv3638920 CNV loss 21293372
esv3638919 CNV loss 21293372
esv3638917 CNV loss 21293372
esv3638916 CNV loss 21293372
esv3638913 CNV gain 21293372
esv3433094 CNV insertion 20981092
esv2751611 CNV loss 17911159
esv2714660 CNV deletion 23290073
esv2714659 CNV deletion 23290073
esv2657396 CNV deletion 23128226

Variation tolerance for TANGO6 Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.47; 64.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TANGO6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TANGO6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TANGO6 Gene

Disorders for TANGO6 Gene

Relevant External Links for TANGO6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TANGO6

No disorders were found for TANGO6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TANGO6 Gene

Publications for TANGO6 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3 64
  5. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 4 64

Products for TANGO6 Gene

Sources for TANGO6 Gene

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