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Aliases for TANGO2 Gene

Aliases for TANGO2 Gene

  • Transport And Golgi Organization 2 Homolog 2 3 5
  • C22orf25 3 4
  • Transport And Golgi Organization 2 Homolog (Drosophila) 2
  • Chromosome 22 Open Reading Frame 25 2
  • MECRCN 3

External Ids for TANGO2 Gene

Previous HGNC Symbols for TANGO2 Gene

  • C22orf25

Summaries for TANGO2 Gene

Entrez Gene Summary for TANGO2 Gene

  • This gene belongs to the transport and Golgi organization family, whose members are predicted to play roles in secretory protein loading in the endoplasmic reticulum. Depletion of this gene in Drosophila S2 cells causes fusion of the Golgi with the ER. In mouse tissue culture cells, this protein co-localizes with a mitochondrially targeted mCherry protein and displays very low levels of co-localization with Golgi and peroxisomes. Allelic variants of this gene are associated with rhabdomyolysis, metabolic crises with encephalopathy, and cardiac arrhythmia. [provided by RefSeq, Apr 2016]

GeneCards Summary for TANGO2 Gene

TANGO2 (Transport And Golgi Organization 2 Homolog) is a Protein Coding gene. Diseases associated with TANGO2 include Seizure Disorder and Visual Epilepsy.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TANGO2 Gene

Genomics for TANGO2 Gene

Regulatory Elements for TANGO2 Gene

Enhancers for TANGO2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TANGO2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TANGO2 Gene

Chromosome:
22
Start:
20,017,000 bp from pter
End:
20,065,926 bp from pter
Size:
48,927 bases
Orientation:
Plus strand

Genomic View for TANGO2 Gene

Genes around TANGO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TANGO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TANGO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TANGO2 Gene

Proteins for TANGO2 Gene

  • Protein details for TANGO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ICL3-TNG2_HUMAN
    Recommended name:
    Transport and Golgi organization protein 2 homolog
    Protein Accession:
    Q6ICL3
    Secondary Accessions:
    • A8MUE9
    • B7WNV6
    • B7Z583
    • B7Z730
    • D3DX23
    • Q8IW05
    • Q8NAL0
    • Q8TCS0
    • Q96M16

    Protein attributes for TANGO2 Gene

    Size:
    276 amino acids
    Molecular mass:
    30937 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TANGO2 Gene

neXtProt entry for TANGO2 Gene

Proteomics data for TANGO2 Gene at MOPED

Post-translational modifications for TANGO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TANGO2 Gene

Domains & Families for TANGO2 Gene

Protein Domains for TANGO2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6ICL3

UniProtKB/Swiss-Prot:

TNG2_HUMAN :
  • Belongs to the Tango2 family.
Family:
  • Belongs to the Tango2 family.
genes like me logo Genes that share domains with TANGO2: view

No data available for Gene Families for TANGO2 Gene

Function for TANGO2 Gene

genes like me logo Genes that share phenotypes with TANGO2: view

Animal Model Products

miRNA for TANGO2 Gene

miRTarBase miRNAs that target TANGO2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TANGO2 Gene

Localization for TANGO2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TANGO2 Gene

Pathways & Interactions for TANGO2 Gene

SuperPathways for TANGO2 Gene

No Data Available

Interacting Proteins for TANGO2 Gene

Gene Ontology (GO) - Biological Process for TANGO2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TANGO2 Gene

Drugs & Compounds for TANGO2 Gene

No Compound Related Data Available

Transcripts for TANGO2 Gene

Unigene Clusters for TANGO2 Gene

Transport and golgi organization 2 homolog (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TANGO2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - -
SP2: -
SP3: - - - -
SP4: - - - - -
SP5: - -
SP6: -
SP7: -
SP8:
SP9: - - - -

Relevant External Links for TANGO2 Gene

GeneLoc Exon Structure for
TANGO2
ECgene alternative splicing isoforms for
TANGO2

Expression for TANGO2 Gene

mRNA expression in normal human tissues for TANGO2 Gene

mRNA differential expression in normal tissues according to GTEx for TANGO2 Gene

This gene is overexpressed in Whole Blood (x5.7).

Protein differential expression in normal tissues from HIPED for TANGO2 Gene

This gene is overexpressed in Spleen (9.8), Peripheral blood mononuclear cells (9.4), and Platelet (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TANGO2 Gene



SOURCE GeneReport for Unigene cluster for TANGO2 Gene Hs.474233

genes like me logo Genes that share expression patterns with TANGO2: view

Protein tissue co-expression partners for TANGO2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TANGO2 Gene

Orthologs for TANGO2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TANGO2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TANGO2 35
  • 85.27 (n)
  • 82.97 (a)
TANGO2 36
  • 85 (a)
OneToMany
TANGO2 36
  • 79 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TANGO2 35
  • 86.59 (n)
  • 90.58 (a)
TANGO2 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tango2 35
  • 84.3 (n)
  • 87.68 (a)
Tango2 16
Tango2 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tango2 35
  • 83.57 (n)
  • 86.96 (a)
oppossum
(Monodelphis domestica)
Mammalia TANGO2 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TANGO2 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves C15H22ORF25 35
  • 68.36 (n)
  • 73.45 (a)
TANGO2 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20456 35
tango2 35
  • 66.91 (n)
  • 68 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68627 35
zebrafish
(Danio rerio)
Actinopterygii tango2 35
  • 66.18 (n)
  • 65.07 (a)
tango2 36
  • 64 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8435 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002962 35
  • 48.76 (n)
  • 36.57 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tango2 35
  • 46.64 (n)
  • 31.4 (a)
Tango2 36
  • 26 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R186.1 35
  • 41.35 (n)
  • 32.06 (a)
R186.1 36
  • 31 (a)
OneToMany
Y80D3A.9 36
  • 27 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 26 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G38260 35
  • 44.27 (n)
  • 32.43 (a)
rice
(Oryza sativa)
Liliopsida Os09g0323500 35
  • 47.75 (n)
  • 34.75 (a)
Species with no ortholog for TANGO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TANGO2 Gene

ENSEMBL:
Gene Tree for TANGO2 (if available)
TreeFam:
Gene Tree for TANGO2 (if available)

Paralogs for TANGO2 Gene

genes like me logo Genes that share paralogs with TANGO2: view

No data available for Paralogs for TANGO2 Gene

Variants for TANGO2 Gene

Sequence variations from dbSNP and Humsavar for TANGO2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs17855650 - 20,053,544(+) CAGCC(A/G)ACCTG intron-variant, reference, missense
rs17854107 - 20,061,676(+) ACAAT(A/G)AAGAG intron-variant, downstream-variant-500B, reference, missense
rs16982614 - 20,064,566(+) GTAGA(G/T)GCGGA nc-transcript-variant, reference, missense, utr-variant-3-prime
rs2097604 -- 20,020,997(+) GGGAC(A/G)CCGGC intron-variant, upstream-variant-2KB
rs7287655 -- 20,024,495(+) GGCTG(A/C)CACCG intron-variant

Variation tolerance for TANGO2 Gene

Residual Variation Intolerance Score: 72.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.73; 46.63% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TANGO2 Gene

Disorders for TANGO2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TANGO2 Gene - From: ClinVar

Disorder Aliases PubMed IDs
seizure disorder
  • epilepsy
visual epilepsy
  • epilepsy, visual
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TANGO2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TANGO2
genes like me logo Genes that share disorders with TANGO2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TANGO2 Gene

Publications for TANGO2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Recurrent Muscle Weakness with Rhabdomyolysis, Metabolic Crises, and Cardiac Arrhythmia Due to Bi-allelic TANGO2 Mutations. (PMID: 26805781) Lalani S.R. … Yang Y. (Am. J. Hum. Genet. 2016) 3
  4. Bi-allelic Truncating Mutations in TANGO2 Cause Infancy-Onset Recurrent Metabolic Crises with Encephalocardiomyopathy. (PMID: 26805782) Kremer L.S. … Haack T.B. (Am. J. Hum. Genet. 2016) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for TANGO2 Gene

Sources for TANGO2 Gene

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