Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TANGO2 Gene

Aliases for TANGO2 Gene

  • Transport And Golgi Organization 2 Homolog 2 3 5
  • C22orf25 3 4
  • Transport And Golgi Organization 2 Homolog (Drosophila) 2
  • Transport And Golgi Organization Protein 2 Homolog 3
  • Chromosome 22 Open Reading Frame 25 2
  • MECRCN 3

External Ids for TANGO2 Gene

Previous HGNC Symbols for TANGO2 Gene

  • C22orf25

Summaries for TANGO2 Gene

Entrez Gene Summary for TANGO2 Gene

  • This gene belongs to the transport and Golgi organization family, whose members are predicted to play roles in secretory protein loading in the endoplasmic reticulum. Depletion of this gene in Drosophila S2 cells causes fusion of the Golgi with the ER. In mouse tissue culture cells, this protein co-localizes with a mitochondrially targeted mCherry protein and displays very low levels of co-localization with Golgi and peroxisomes. Allelic variants of this gene are associated with rhabdomyolysis, metabolic crises with encephalopathy, and cardiac arrhythmia. [provided by RefSeq, Apr 2016]

GeneCards Summary for TANGO2 Gene

TANGO2 (Transport And Golgi Organization 2 Homolog) is a Protein Coding gene. Diseases associated with TANGO2 include Metabolic Encephalomyopathic Crises, Recurrent, With Rhabdomyolysis, Cardiac Arrhythmias, And Neurodegeneration and Cardiac Conduction Disease With Or Without Dilated Cardiomyopathy.

Additional gene information for TANGO2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TANGO2 Gene

Genomics for TANGO2 Gene

Regulatory Elements for TANGO2 Gene

Enhancers for TANGO2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H019889 1.6 Ensembl ENCODE dbSUPER 5.2 -124.7 -124735 5 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B FEZF1 SLC30A9 ZNF766 CBX5 TBX1 RPL8P5 RTL10 TXNRD2 TANGO2 COMT PIR37139
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TANGO2 on UCSC Golden Path with GeneCards custom track

Promoters for TANGO2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000143841 -300 1401 HDGF PKNOX1 ATF1 ARNT ARID4B DMAP1 ZNF121 GLIS2 ZNF143 ATF7

Genomic Locations for TANGO2 Gene

Genomic Locations for TANGO2 Gene
48,927 bases
Plus strand

Genomic View for TANGO2 Gene

Genes around TANGO2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TANGO2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TANGO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TANGO2 Gene

Proteins for TANGO2 Gene

  • Protein details for TANGO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transport and Golgi organization protein 2 homolog
    Protein Accession:
    Secondary Accessions:
    • A8MUE9
    • B7WNV6
    • B7Z583
    • B7Z730
    • D3DX23
    • Q8IW05
    • Q8NAL0
    • Q8TCS0
    • Q96M16

    Protein attributes for TANGO2 Gene

    276 amino acids
    Molecular mass:
    30937 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TANGO2 Gene

neXtProt entry for TANGO2 Gene

Post-translational modifications for TANGO2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TANGO2 Gene

Domains & Families for TANGO2 Gene

Gene Families for TANGO2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TANGO2 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Tango2 family.
  • Belongs to the Tango2 family.
genes like me logo Genes that share domains with TANGO2: view

Function for TANGO2 Gene

Phenotypes From GWAS Catalog for TANGO2 Gene

genes like me logo Genes that share phenotypes with TANGO2: view

Human Phenotype Ontology for TANGO2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for TANGO2 Gene

miRTarBase miRNAs that target TANGO2

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for TANGO2 Gene

Localization for TANGO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TANGO2 Gene

Golgi apparatus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TANGO2 gene
Compartment Confidence
golgi apparatus 5
cytosol 3
nucleus 2
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TANGO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IDA 26805781
genes like me logo Genes that share ontologies with TANGO2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TANGO2 Gene

Pathways & Interactions for TANGO2 Gene

SuperPathways for TANGO2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TANGO2 Gene


No data available for Pathways by source and SIGNOR curated interactions for TANGO2 Gene

Drugs & Compounds for TANGO2 Gene

No Compound Related Data Available

Transcripts for TANGO2 Gene

Unigene Clusters for TANGO2 Gene

Transport and golgi organization 2 homolog (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TANGO2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: - -
SP2: -
SP3: - - - -
SP4: - - - - -
SP5: - -
SP6: -
SP7: -
SP9: - - - -

Relevant External Links for TANGO2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TANGO2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TANGO2 Gene

mRNA differential expression in normal tissues according to GTEx for TANGO2 Gene

This gene is overexpressed in Whole Blood (x5.7).

Protein differential expression in normal tissues from HIPED for TANGO2 Gene

This gene is overexpressed in Spleen (9.8), Peripheral blood mononuclear cells (9.4), and Platelet (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TANGO2 Gene

Protein tissue co-expression partners for TANGO2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TANGO2 Gene:


SOURCE GeneReport for Unigene cluster for TANGO2 Gene:


Evidence on tissue expression from TISSUES for TANGO2 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with TANGO2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TANGO2 Gene

Orthologs for TANGO2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TANGO2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TANGO2 34
  • 92 (a)
(Canis familiaris)
Mammalia TANGO2 33 34
  • 86.59 (n)
(Bos Taurus)
Mammalia TANGO2 33 34 34
  • 85.27 (n)
(Mus musculus)
Mammalia Tango2 33 16 34
  • 84.3 (n)
(Rattus norvegicus)
Mammalia Tango2 33
  • 83.57 (n)
(Monodelphis domestica)
Mammalia TANGO2 34
  • 76 (a)
(Gallus gallus)
Aves TANGO2 34
  • 73 (a)
C15H22ORF25 33
  • 68.36 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia tango2 33
  • 66.91 (n)
Str.20456 33
African clawed frog
(Xenopus laevis)
Amphibia MGC68627 33
(Danio rerio)
Actinopterygii tango2 33 34
  • 66.18 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8435 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002962 33
  • 48.76 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tango2 33 34
  • 46.64 (n)
(Caenorhabditis elegans)
Secernentea R186.1 33 34
  • 41.35 (n)
Y80D3A.9 34
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 26 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G38260 33
  • 44.27 (n)
(Oryza sativa)
Liliopsida Os09g0323500 33
  • 47.75 (n)
Species where no ortholog for TANGO2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TANGO2 Gene

Gene Tree for TANGO2 (if available)
Gene Tree for TANGO2 (if available)

Paralogs for TANGO2 Gene

genes like me logo Genes that share paralogs with TANGO2: view

No data available for Paralogs for TANGO2 Gene

Variants for TANGO2 Gene

Sequence variations from dbSNP and Humsavar for TANGO2 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs752298579 Pathogenic, Metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration (MECRCN) [MIM:616878] 20,061,538(+) CCTAC(A/G)GGCTG intron-variant, nc-transcript-variant, reference, missense
rs372949028 Pathogenic 20,061,684(+) GAGGC(A/G)TGAGT intron-variant, nc-transcript-variant, splice-donor-variant
rs764883927 Pathogenic 20,055,980(+) GGAAC(C/T)GAGGG intron-variant, nc-transcript-variant, reference, stop-gained
rs869320693 Pathogenic 20,036,802(+) CCATG(-/T)GCATC nc-transcript-variant, upstream-variant-2KB, reference, frameshift-variant, utr-variant-5-prime
rs1000022300 -- 20,015,424(+) CACTG(A/G)CATGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TANGO2 Gene

Variant ID Type Subtype PubMed ID
nsv471183 CNV loss 18288195
nsv473218 CNV novel sequence insertion 20440878
nsv521042 CNV loss 19592680
nsv588243 CNV loss 21841781
nsv588246 CNV loss 21841781
nsv588247 CNV loss 21841781
nsv828938 CNV gain 20364138
nsv828939 CNV loss 20364138
nsv834133 CNV loss 17160897
nsv953026 CNV deletion 24416366
nsv469641 CNV loss 16826518
nsv433325 CNV loss 18776910
nsv3560 CNV insertion 18451855
nsv1056768 CNV loss 25217958
esv3893434 CNV gain 25118596
esv3647286 CNV loss 21293372
esv3647285 CNV loss 21293372
esv3647284 CNV gain 21293372
esv2758825 CNV loss 17122850
esv2658430 CNV deletion 23128226
dgv7985n54 CNV loss 21841781
dgv7983n54 CNV gain 21841781
dgv72n68 CNV loss 17160897
dgv4479n100 CNV loss 25217958

Variation tolerance for TANGO2 Gene

Residual Variation Intolerance Score: 72.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.73; 46.63% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TANGO2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TANGO2 Gene

Disorders for TANGO2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TANGO2 Gene - From: HGMD, OMIM, ClinVar, Swiss-Prot, and GeneCards

Disorder Aliases PubMed IDs
metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration
  • mecrcn
cardiac conduction disease with or without dilated cardiomyopathy
  • familial atrial tachyarrhythmia-infra-hisian cardiac conduction disease
visual epilepsy
  • epilepsy, visual
seizure disorder
  • seizure disorders
- elite association - COSMIC cancer census association via MalaCards


  • Metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration (MECRCN) [MIM:616878]: An autosomal recessive disorder characterized by metabolic encephalomyopathic crises, hypoglycemia, hyperammonemia, episodic rhabdomyolysis, susceptibility to life-threatening cardiac tachyarrhythmias, developmental delay, mental retardation, and mild diffuse cerebral atrophy. {ECO:0000269 PubMed:26805781, ECO:0000269 PubMed:26805782}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TANGO2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TANGO2: view

No data available for Genatlas for TANGO2 Gene

Publications for TANGO2 Gene

  1. Recurrent Muscle Weakness with Rhabdomyolysis, Metabolic Crises, and Cardiac Arrhythmia Due to Bi-allelic TANGO2 Mutations. (PMID: 26805781) Lalani SR … Yang Y (American journal of human genetics 2016) 2 3 4 60
  2. Bi-allelic Truncating Mutations in TANGO2 Cause Infancy-Onset Recurrent Metabolic Crises with Encephalocardiomyopathy. (PMID: 26805782) Kremer LS … Haack TB (American journal of human genetics 2016) 2 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for TANGO2 Gene

Sources for TANGO2 Gene

Loading form....