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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TANGO2 Gene

protein-coding   GIFtS: 41
GCID: GC22P020005

Transport And Golgi Organization 2 Homolog (Drosophila)

(Previous name: chromosome 22 open reading frame 25)
(Previous symbol: C22orf25)
  Search for TANGO2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transport And Golgi Organization 2 Homolog (Drosophila)1 2
C22orf251 2 3
Chromosome 22 Open Reading Frame 251
Transport And Golgi Organization Protein 2 Homolog2

External Ids:    HGNC: 254391   Entrez Gene: 1289892   Ensembl: ENSG000001835977   UniProtKB: Q6ICL33   

Export aliases for TANGO2 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TANGO2 Gene: 
TANGO2 (transport and golgi organization 2 homolog (Drosophila)) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NT_011519.10  NC_018933.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TANGO2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTANGO2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TANGO2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TANGO2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.21

TANGO2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TANGO2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P020005:  view genomic region     (about GC identifiers)

Start:
20,004,537 bp from pter      End:
20,053,449 bp from pter
Size:
48,913 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TNG2_HUMAN, Q6ICL3 (See protein sequence)
Recommended Name: Transport and Golgi organization protein 2 homolog  
Size: 276 amino acids; 30937 Da
Secondary accessions: A8MUE9 D3DX23 Q8IW05 Q8NAL0 Q8TCS0 Q96M16
Alternative splicing: 3 isoforms:  Q6ICL3-1   Q6ICL3-2   Q6ICL3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TANGO2: NX_Q6ICL3

Explore proteomics data for TANGO2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6ICL3

  • TANGO2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TANGO2 Protein Expression
    REFSEQ proteins (12 alternative transcripts): 
    NP_001270035.1  NP_001270045.1  NP_001270058.1  NP_001270077.1  NP_001270083.1  NP_001270108.1  NP_001270115.1  NP_001270128.1  
    NP_001270144.1  NP_001270164.1  NP_001270177.1  NP_690870.3  

    ENSEMBL proteins: 
     ENSP00000385662   ENSP00000413850   ENSP00000381122   ENSP00000382706   ENSP00000415450  
     ENSP00000402966   ENSP00000332721   ENSP00000403432   ENSP00000384827   ENSP00000411602  
     ENSP00000395816   ENSP00000389797   ENSP00000402926   ENSP00000391262   ENSP00000403645  
     ENSP00000396182  

    Human Recombinant Protein Products for TANGO2: 
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--

    TANGO2 for ontologies           About GeneDecksing



    TANGO2 Antibody Products: 
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR008551 DUF833

    Graphical View of Domain Structure for InterPro Entry Q6ICL3

    ProtoNet protein and cluster: Q6ICL3

    UniProtKB/Swiss-Prot: TNG2_HUMAN, Q6ICL3
    Similarity: Belongs to the Tango2 family


    TANGO2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         4 GenomeRNAi human phenotypes for TANGO2:
     Decreased viability with pacli  Elongated cells  G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TANGO2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TANGO2 
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    miRNA
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    Inhib. RNA
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    Search LifeMap BioReagents cell lines for TANGO2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TANGO2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TANGO2

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5/8 Interacting proteins for TANGO2 (Q6ICL33 ENSP000003327214) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CTHP329293, ENSP000003599764I2D: score=2 STRING: ENSP00000359976
    ATP6V1E1P365433I2D: score=5 
    KCND3Q9UK173I2D: score=5 
    EPS8L2Q9H6S33I2D: score=4 
    PAX9P557713I2D: score=4 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TANGO2 (TNG2)

    Search CenterWatch for drugs/clinical trials and news about TANGO2 / TNG2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TANGO2 gene (12 alternative transcripts): 
    NM_001283106.1  NM_001283116.1  NM_001283129.1  NM_001283148.1  NM_001283154.1  NM_001283179.1  NM_001283186.1  NM_001283199.1  
    NM_001283215.1  NM_001283235.1  NM_001283248.1  NM_152906.5  

    Unigene Cluster for TANGO2:

    Transport and golgi organization 2 homolog (Drosophila)
    Hs.474233  [show with all ESTs]
    Unigene Representative Sequence: CR627452
    18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000471707 ENST00000401886 ENST00000475446 ENST00000432198 ENST00000411907
    ENST00000398042(uc002zrf.2 uc011ahf.1) ENST00000399807(uc002zrg.2 uc011ahg.1 uc010gry.1)
    ENST00000450664 ENST00000450019 ENST00000327374(uc010grw.2 uc002zrc.1 uc011ahh.1 uc011ahi.1 uc011ahe.1)
    ENST00000479679 ENST00000430807 ENST00000401833 ENST00000434168 ENST00000462579
    ENST00000444651 ENST00000484373(uc002zre.2 uc010grx.2) ENST00000485715

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TANGO2
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TANGO2
    SwitchGear 3'UTR luciferase reporter plasmidTANGO2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of TANGO2 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TANGO2

    Additional mRNA sequence: 

    AK092484.1 AK289862.1 AK295210.1 AK297075.1 AK297922.1 AK298593.1 AK301054.1 AK301366.1 
    AK309398.1 AK311676.1 AK316020.1 AK316056.1 AL713640.1 BC041339.1 CR456355.1 CR627452.1 

    24/34 DOTS entries (see all 34):

    DT.100823096  DT.95204803  DT.40208389  DT.92467697  DT.100823098  DT.100771208  DT.100840938  DT.120644392 
    DT.120644649  DT.91819849  DT.120644386  DT.120644698  DT.120644433  DT.120644674  DT.120644699  DT.70102591 
    DT.100027900  DT.120644477  DT.91857099  DT.92068929  DT.95204785  DT.100663123  DT.100663124  DT.100757439 

    24/449 AceView cDNA sequences (see all 449):

    BI253857 AI919304 BM148106 H55281 AA662752 BU839160 CR622984 BU173566 
    AI929630 BM920731 NM_022720 BX092967 CB266089 CR456356 BG685068 AI611670 
    CD109384 AA604799 BP374139 BM264488 CD631584 AI906092 BU188695 AI651982 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TANGO2 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c
    SP1:                                -                 -                                                   
    SP2:                                -                                                                     
    SP3:                                -                 -     -                 -                           
    SP4:                                -                 -     -     -     -                                 
    SP5:                                                  -     -                                             


    ECgene alternative splicing isoforms for TANGO2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    See TANGO2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TANGO2

    SOURCE GeneReport for Unigene cluster: Hs.474233
        SABiosciences Custom PCR Arrays for TANGO2
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TANGO2 gene from 9/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tango25
    D16H22S680E1
    DNA segment, Chr 16, human D22S680E, expressed1, 5 84.3(n)1
    87.68(a)1
      16 (11.34 cM)5
    278831  NM_138583.21  NP_613049.21 
     183008255 
    chicken
    (Gallus gallus)
    Aves C15H22orf251 chromosome 15 open reading frame, human C22orf25 68.37(n)
    73.72(a)
      416784  NM_001007836.1  NP_001007837.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686272 hypothetical protein MGC68627 73.15(n)    BC063724.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1009521 zgc:100952 66.05(n)
    65.07(a)
      445324  NM_001003781.1  NP_001003781.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Tango21 Transport and Golgi organization 2 46.64(n)
    31.4(a)
      32319  NM_132677.3  NP_572905.1 
    worm
    (Caenorhabditis elegans)
    Secernentea R186.11 Protein R186.1 41.35(n)
    32.06(a)
      179780  NM_073842.2  NP_506243.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YGR127W6
    Putative protein of unknown function; expression i...
    25(a)
    1 ↔ 1
    VII(746798-747736)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G382601 hypothetical protein 44.53(n)
    32.43(a)
      829983  NM_119988.4  NP_568038.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g03235001 hypothetical protein 47.62(n)
    34.75(a)
      4346725  NM_001069406.1  NP_001062871.1 


    ENSEMBL Gene Tree for TANGO2 (if available)
    TreeFam Gene Tree for TANGO2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TANGO2 gene
    1 SIMAP similar gene for TANGO2 using alignment to 11 protein entries:     TNG2_HUMAN (see all proteins):
    DKFZp686O2142

    TANGO2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1057 SNPs in TANGO2 are shown (see all 1057)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs747313431,2
    C,F--20006711(+) CCATGC/TGGACA 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs25317021,2
    C,F--20006712(+) CATGCG/AGACAG 1 -- us2k13Minor allele frequency- A:0.06CSA WA NA 239
    rs1920253961,2
    --20006863(+) GAGGTC/TGGATG 1 -- us2k10--------
    rs18587701,2
    C,F,H--20006992(+) GACAAA/CGAAGA 1 -- us2k125Minor allele frequency- C:0.16NS EA NA WA CSA 2768
    rs1469602721,2
    --20007167(+) TTTGAA/GGTGCA 1 -- us2k10--------
    rs1509562521,2
    --20007264(+) CTTGTC/TCACCA 1 -- us2k10--------
    rs790929331,2
    F--20007379(+) CATGTC/GTGGCT 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1151490551,2
    F--20007392(+) GTCTGC/TGGCCC 1 -- us2k11Minor allele frequency- T:0.08WA 118
    rs1112623651,2
    C,F--20007431(+) GTCCTC/TGTAAA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs72889961,2
    C,F--20007599(+) CCTAGG/ATCTTC 1 -- us2k12Minor allele frequency- A:0.31NA 122

    HapMap Linkage Disequilibrium report for TANGO2 (20004537 - 20053449 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TANGO2: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TANGO2
    DNA2.0 Custom Variant and Variant Library Synthesis for TANGO2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TANGO2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TANGO2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I....O'Brien K.P. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 128989 HGNC: 25439 AceView: DGCR8andDKFZp761P1121 Ensembl:ENSG00000183597 euGenes: HUgn128989
    ECgene: TANGO2 H-InvDB: TANGO2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TANGO2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TANGO2 gene:
    Search GeneIP for patents involving TANGO2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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