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Aliases for TANC2 Gene

Aliases for TANC2 Gene

  • Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Containing 2 2 3 5
  • Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Domain-Containing Protein 2 3 4
  • Putative Ankyrin-Repeat Containing Protein 3
  • Rolling Pebbles Homolog B (Drosophila) 2
  • Rolling Pebbles Homolog B 3
  • Protein TANC2 3
  • KIAA1148 4
  • KIAA1636 4
  • ROLSA 3
  • Rols 3

External Ids for TANC2 Gene

Previous GeneCards Identifiers for TANC2 Gene

  • GC17P058397
  • GC17P058625
  • GC17P061086
  • GC17P056455

Summaries for TANC2 Gene

GeneCards Summary for TANC2 Gene

TANC2 (Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Containing 2) is a Protein Coding gene. Diseases associated with TANC2 include Oral Hairy Leukoplakia. An important paralog of this gene is TANC1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TANC2 Gene

Genomics for TANC2 Gene

Regulatory Elements for TANC2 Gene

Enhancers for TANC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F062818 1.6 FANTOM5 Ensembl ENCODE 7 -144.4 -144429 7.4 HDGF PKNOX1 SIN3A YBX1 ZNF207 FOS ZNF592 MBD2 SREBF1 MAFF TANC2 GC17P062830 LOC101927877
GH17F062986 0.7 ENCODE 12.4 +20.1 20058 1.3 CTCF ZNF211 MTA2 JUNB TBX21 ZBTB40 RAD21 SP1 IRF1 MLLT1 TANC2 MIR633 MRC2 CYB561 ENSG00000265971 GC17P062984 GC17P062996
GH17F063273 1.6 FANTOM5 Ensembl ENCODE 5.3 +309.2 309205 4.8 PKNOX1 INSM2 RAD21 ZNF48 ZEB1 RFX5 ZNF366 RCOR1 ETV6 FOS CYB561 DDX42 RPS10P26 EEF1DP7 ENSG00000265282 TANC2 KCNH6 MAP3K3 LIMD2 GC17M063258
GH17F062965 1.1 ENCODE 7.7 +0.5 509 4.2 PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 ZNF143 DEK ZNF263 SP3 MED13 CYB561 TRMT112P3 LOC100419888 CSH2 LOC101927877 ENSG00000263501 RPS23P7 RPLP2P5 ENSG00000263887
GH17F063149 1.1 Ensembl ENCODE 5.4 +184.7 184667 3.1 SIN3A ZNF384 BCL11B HIC1 ZNF664 POLR2A ZNF366 PATZ1 SCRT2 PRDM10 CYB561 TANC2 GC17P063148 LOC100421525
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TANC2 on UCSC Golden Path with GeneCards custom track

Promoters for TANC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001350809 536 3201 PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 ZNF143 DEK ZNF263 SP3

Genomic Location for TANC2 Gene

62,966,664 bp from pter
63,427,706 bp from pter
461,043 bases
Plus strand

Genomic View for TANC2 Gene

Genes around TANC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TANC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TANC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TANC2 Gene

Proteins for TANC2 Gene

  • Protein details for TANC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein TANC2
    Protein Accession:
    Secondary Accessions:
    • Q9HAC3
    • Q9NW88
    • Q9NXY9
    • Q9ULS2

    Protein attributes for TANC2 Gene

    1990 amino acids
    Molecular mass:
    219650 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAB92314.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB92314.1; Type=Frameshift; Positions=1221; Evidence={ECO:0000305};

    Alternative splice isoforms for TANC2 Gene


neXtProt entry for TANC2 Gene

Post-translational modifications for TANC2 Gene

  • Glycosylation at Asn 1928
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TANC2 Gene

Domains & Families for TANC2 Gene

Suggested Antigen Peptide Sequences for TANC2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TANC family.
  • Contains 11 ANK repeats.
  • Belongs to the TANC family.
  • Contains 11 ANK repeats.
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with TANC2: view

Function for TANC2 Gene

genes like me logo Genes that share phenotypes with TANC2: view

Animal Model Products

miRNA for TANC2 Gene

miRTarBase miRNAs that target TANC2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TANC2 Gene

Localization for TANC2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TANC2 gene
Compartment Confidence
cytosol 4
nucleus 2
plasma membrane 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TANC2 Gene

Pathways & Interactions for TANC2 Gene

SuperPathways for TANC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TANC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
genes like me logo Genes that share ontologies with TANC2: view

No data available for Pathways by source and SIGNOR curated interactions for TANC2 Gene

Drugs & Compounds for TANC2 Gene

(1) Drugs for TANC2 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium channel blockers Pharma 1940
genes like me logo Genes that share compounds with TANC2: view

Transcripts for TANC2 Gene

Unigene Clusters for TANC2 Gene

Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TANC2 Gene

No ASD Table

Relevant External Links for TANC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TANC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TANC2 Gene

Protein differential expression in normal tissues from HIPED for TANC2 Gene

This gene is overexpressed in Tlymphocyte (11.7), Bone (11.0), Lung (10.3), Skin (9.0), Fetal Brain (8.6), and Frontal cortex (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TANC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TANC2 Gene:


SOURCE GeneReport for Unigene cluster for TANC2 Gene:

genes like me logo Genes that share expression patterns with TANC2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TANC2 Gene

Orthologs for TANC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TANC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TANC2 34 35
  • 99.66 (n)
(Canis familiaris)
Mammalia TANC2 34 35
  • 93.58 (n)
(Mus musculus)
Mammalia Tanc2 34 16 35
  • 92.09 (n)
(Monodelphis domestica)
Mammalia TANC2 35
  • 92 (a)
(Rattus norvegicus)
Mammalia Tanc2 34
  • 91.94 (n)
(Bos Taurus)
Mammalia TANC2 34 35
  • 91.39 (n)
(Ornithorhynchus anatinus)
Mammalia TANC2 35
  • 91 (a)
(Gallus gallus)
Aves TANC2 34 35
  • 81.52 (n)
(Anolis carolinensis)
Reptilia TANC2 35
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tanc2 34
  • 75.1 (n)
(Danio rerio)
Actinopterygii TANC2 (1 of 2) 35
  • 74 (a)
tanc2 34 35
  • 68.74 (n)
Dr.8965 34
fruit fly
(Drosophila melanogaster)
Insecta rols 35
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1817 35
  • 42 (a)
-- 35
  • 41 (a)
-- 35
  • 38 (a)
Species where no ortholog for TANC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TANC2 Gene

Gene Tree for TANC2 (if available)
Gene Tree for TANC2 (if available)

Paralogs for TANC2 Gene Pseudogenes for TANC2 Gene

genes like me logo Genes that share paralogs with TANC2: view

Variants for TANC2 Gene

Sequence variations from dbSNP and Humsavar for TANC2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1015760 -- 63,340,521(+) CTACT(A/C)CTTCC intron-variant, upstream-variant-2KB
rs1029764 -- 63,381,706(+) ATCTT(A/C)AGATA intron-variant
rs1029765 -- 63,381,923(+) GAGGC(A/G)CTTTT intron-variant
rs1029883 -- 63,179,998(-) acacc(A/C)aggct intron-variant
rs10438757 -- 63,086,635(+) ttgtt(C/T)acatt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TANC2 Gene

Variant ID Type Subtype PubMed ID
nsv954586 CNV deletion 24416366
nsv833509 CNV gain+loss 17160897
nsv575853 CNV loss 21841781
nsv575851 CNV loss 21841781
nsv575848 CNV loss 21841781
nsv575846 CNV loss 21841781
nsv526079 CNV gain 19592680
nsv480262 CNV novel sequence insertion 20440878
nsv477071 CNV novel sequence insertion 20440878
nsv457867 CNV loss 19166990
nsv457866 CNV loss 19166990
nsv457865 CNV loss 19166990
nsv2116 CNV insertion 18451855
nsv112050 CNV insertion 16902084
nsv1109101 CNV deletion 24896259
nsv1064059 CNV gain 25217958
esv3640991 CNV loss 21293372
esv3640990 CNV loss 21293372
esv3640986 CNV gain 21293372
esv3640984 CNV gain 21293372
esv3640982 CNV loss 21293372
esv3436323 CNV insertion 20981092
esv3349047 CNV insertion 20981092
esv27080 CNV loss 19812545
esv2657672 CNV deletion 23128226
dgv580e214 CNV loss 21293372
dgv5742n54 CNV loss 21841781
dgv5741n54 CNV loss 21841781

Variation tolerance for TANC2 Gene

Residual Variation Intolerance Score: 0.325% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.00; 49.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TANC2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TANC2 Gene

Disorders for TANC2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TANC2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
oral hairy leukoplakia
  • hairy leukoplakia
- elite association - COSMIC cancer census association via MalaCards
Search TANC2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TANC2

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TANC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TANC2 Gene

Publications for TANC2 Gene

  1. Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins. (PMID: 21068316) Han S. … Kim E. (J. Neurosci. 2010) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 64
  4. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 3 4 64
  5. Interactome of the negative regulator of nuclear import BRCA1-binding protein 2. (PMID: 25820252) Fatima S. … Jans D.A. (Sci. Rep. 2015) 3 64

Products for TANC2 Gene

Sources for TANC2 Gene

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