TANC2 Gene
protein-coding GIFtS: 46
GCID: GC17P061086
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tetratricopeptide repeat, ankyrin repeat and coiled-coil...
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Aliases
for TANC2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Containing 21 2 | | DKFZP564D1661 | | ROLSA1 2 | | FLJ102151 | | Rols1 | | FLJ118241 | | KIAA11481 3 | | Protein TANC22 | | KIAA16361 3 | | Putative Ankyrin-Repeat Containing Protein2 | | Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Domain-ContainingProtein 22 3 | | Rolling Pebbles Homolog B2 |
Export aliases for TANC2 gene to outside databasesPrevious GC identifers: GC17P058397 GC17P058625 GC17P056455 |
Summaries
for TANC2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TANC2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TANC2 gene promoter:
TBP SRF Pbx1a Nkx2-2 SRF (504 AA) RORalpha2 RORalpha1 FOXJ2 (long isoform) TFIID FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TANC2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TANC2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q23.3 Ensembl cytogenetic band: 17q23.2 HGNC cytogenetic band: 17q23.3TANC2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P061086: view genomic region
(about GC identifiers)
Start:
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61,086,898 bp from pter |
End:
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61,505,067 bp from pter |
Size:
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418,170 bases |
Orientation:
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plus strand |
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Proteins
for TANC2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TANC2_HUMAN, Q9HCD6 (See
protein sequence)Recommended Name: Protein TANC2 Size: 1990 amino acids; 219650 Da
Sequence caution: Sequence=CAB92314.1; Type=Erroneous initiation; Note=Translation N-terminally extended;Sequence=CAB92314.1; Type=Frameshift; Positions=1221;
Secondary accessions: Q9HAC3 Q9NW88 Q9NXY9 Q9ULS2Alternative splicing: 4 isoforms: Q9HCD6-1 Q9HCD6-2 Q9HCD6-3 Q9HCD6-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TANC2: NX_Q9HCD6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9HCD6
TANC2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079461.2
ENSEMBL proteins: ENSP00000387593 ENSP00000374171 ENSP00000463062 ENSP00000463959 ENSP00000462109 ENSP00000464181
Human Recombinant Protein Products:
TANC2 Antibody Products:
Assay Products for TANC2: |
Protein
Domains /
Families
for TANC2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TANC2 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9HCD6ProtoNet protein and cluster: Q9HCD6 UniProtKB/Swiss-Prot: TANC2_HUMAN, Q9HCD6Similarity: Belongs to the TANC familySimilarity: Contains 11 ANK repeatsSimilarity: Contains 3 TPR repeats |
Function
for TANC2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TANC2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TANC2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TANC2 (NM_025185) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TANC2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TANC2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TANC2 |
1 GenomeRNAi human phenotype for TANC2:
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Tanc2):
TANC2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TANC2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TANC2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
5/526 Interacting proteins for TANC2 (Q9HCD62, 3 ENSP000003875934) via UniProtKB, MINT, STRING, and/or I2D (see all 526)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001701 | in utero embryonic development |
IEA | -- |
TANC2 for ontologies About GeneDecksing
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Drugs & Compounds
for TANC2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TANC2
Search CenterWatch for drugs/clinical trials and news about TANC2
|
Transcripts
for TANC2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TANC2 gene (3 alternative transcripts): NM_015623.2 NM_030658.2 NM_025185.3 Unigene Cluster for TANC2: Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 Hs.410889 [show with all ESTs]Unigene Representative Sequence: NM_02518510 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000424789(uc002jal.4 uc010wpe.2 uc002jao.4) ENST00000389520
ENST00000580068 ENST00000580466 ENST00000581424 ENST00000583356 ENST00000583545(uc002jam.1)
ENST00000581143(uc002jan.1) ENST00000583016 ENST00000579541
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TANC2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TANC2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TANC2 (NM_025185) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TANC2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TANC2 |
Additional cDNA sequence: AB032974.2 AB046856.2 AJ278120.1 BC144357.1 CR936685.1 9 DOTS entries: DT.97795677 DT.451658 DT.120906648 DT.204808 DT.100740413 DT.120906588 DT.120906599 DT.120906653 DT.91890257 24/140 AceView cDNA sequences (see all 140): AA398134 AI929277 CR601835 AA595175 BE220246 BX957147 BX092628 AA707334 AI433843 H73745 AA164719 AA394105 AW590006 AU119826 CD365228 BF439713 BQ021759 AU119728 AI815582 AL049048 AA292298 AL699368 AI131156 Z38433
GeneLoc Exon Structure
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Expression
for TANC2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TANC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATACAGATT
About this image
See TANC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TANC2
SOURCE GeneReport for Unigene cluster: Hs.410889
SABiosciences Custom PCR Arrays for TANC2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TANC2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TANC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TANC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TANC2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TANC2 |
Orthologs
for TANC2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for TANC2 gene from 8/22 species (see all 22) About this table
ENSEMBL Gene Tree for TANC2 (if available)
TreeFam Gene Tree for TANC2 (if available) |
Paralogs
for TANC2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TANC2 gene
- TNKS22 ANKRD172 ANK32 ANKHD12 ANK12 ANKRD522 ANKHD1-EIF4EBP32 TNKS2
- TANC12 ANKRD502 INVS2 ANKRD282 ANK22 ANKRD442
18/21 SIMAP similar genes for TANC2 using alignment to 5 protein entries: TANC2_HUMAN (see all proteins)
(see all similar genes):TANC1 RAI14 ANKRD42 ANK2 ANKRD44 KIDINS220
ANKRD12 DKFZp761E1322 MTPN ANKRD6 FANK1 ANKRD46
ANKRD54 ANKS3 CDKN2C FEM1B GABPB1 ANK3
TANC2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TANC2
PGOHUM00000237043
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Genomic Variants
for TANC2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TANC2 (61086898 - 61336898 bp, first 250kb of TANC2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TANC2
3 CNVs: 5021 67240 88583 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TANC2 |
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Disorders
/ Diseases
for TANC2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TANC2 for disorders About GeneDecksing
OMIM gene information: 615047
OMIM disorders: --
3  diseases for TANC2: About MalaCardsoral candidiasis candidiasis neuronitis
Export disorders for TANC2 gene to outside databases
|
Publications
for TANC2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TANC2 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with TANC2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2 Nagase T.... Ohara O. (2000)
- Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)1, 2 Hirosawa M.... Ohara O. (1999)
- Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PubMed id 22360420)1 Martins-de-Souza D....Bahn S. (2012)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)2 Olsen J.V....Mann M. (2006)
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)2 Zody M.C.... Nusbaum C. (2006)
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External Searches for TANC2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TANC2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TANC2 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing TANC2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TANC2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TANC2 gene:
Search GeneIP for patents involving TANC2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TANC2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TANC2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TANC2 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TANC2 | | OriGene 3'-UTR Clone for TANC2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TANC2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TANC2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TANC2 | | OriGene Custom Protein Services for TANC2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TANC2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TANC2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TANC2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TANC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TANC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TANC2 |
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 | | | TANC2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TANC2 |
|  |  |  | | | | Search ThermoFisher Antibodies for TANC2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TANC2 |
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