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TANC2 Gene

protein-coding GIFtS: 43

GC17P058397

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZP564D166 ^¹
DKFZp564D166 ^²
FLJ10215 ^¹, ²
FLJ11824 ^¹, ²
KIAA1148 ^¹, ², ³
KIAA1636 ^¹, ², ³
ROLSA ^¹, ²
rols ^¹, ²

Descriptions
Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2 ^³
putative ankyrin-repeat containing protein ^²
rolling pebbles homolog B ^²
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 ^²

External Ids
HGNC: 30212¹
Entrez Gene: 26115²
UniProtKB: Q9HCD6³
Ensembl: ENSG00000170921⁷

Search outside databases for aliases for TANC2 gene

Previous GC identifer: GC17P058625

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TANC2 gene

Entrez Gene cytogenetic band: 17q23.3 Ensembl cytogenetic band: 17q23.3 HGNC cytogenetic band: 17q23.3

TANC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P058397: (about GC identifiers)

Start:	58,440,630 bp from pter
End:	58,858,799 bp from pter
Size:	418,170 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010783.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TANC2_HUMAN, Q9HCD6 (See protein sequence)

Recommended Name: Protein TANC2

Size: 1990 amino acids; 219650 Da

Sequence caution: Sequence=CAB92314.1; Type=Erroneous initiation; Note=Translation N-terminally

extended; Sequence=CAB92314.1; Type=Frameshift; Positions=1221;

Secondary accessions: Q9HAC3 Q9NW88 Q9NXY9 Q9ULS2

Alternative splicing: 4 isoforms: Q9HCD6-1 Q9HCD6-2 Q9HCD6-3 Q9HCD6-4

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_079461.2

ENSEMBL proteins:

ENSP00000374171

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for TANC2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for TANC2
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for TANC2

Assays for TANC2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9HCD6

ProtoNet protein and cluster: Q9HCD6

UniProtKB/Swiss-Prot: TANC2_HUMAN, Q9HCD6

Similarity: Belongs to the TANC family

Similarity: Contains 11 ANK repeats

Similarity: Contains 3 TPR repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TANC2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): XM_371074

Applied Biosystems Silencer® siRNAs for TANC2

Sigma-Aldrich siRNA for TANC2

Sigma-Aldrich shRNA for TANC2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_025185
Myc/DDK tagged cDNA clone in CMV expression vector: NM_025185
untagged cDNA clones in CMV expression vector (see all 4): AK001077

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_025185

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005488	binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TANC2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TANC2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): XM_371074

Sigma-Aldrich siRNA for TANC2

Sigma-Aldrich shRNA for TANC2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_025185

REFSEQ mRNAs for TANC2 gene:

NM_025185.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_025185

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_025185
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_025185
                                 untagged cDNA clones in CMV expression vector (see all 4): AK001077

Additional cDNA sequence:

AB032974.2 AB046856.2 AJ278120.1 BC144357.1 CR601835.1 CR936685.1

9 DOTS entries:

DT.97795677 DT.451658 DT.120906648 DT.204808 DT.100740413 DT.120906588 DT.120906599 DT.120906653

DT.91890257

24/140 AceView cDNA sequences (see all 140 ):

BE874850 AI131156 BX092628 CB242493 AK001077 AL699368 AL049048 BQ021759

H73745 AI433843 AI690079 AW438758 AK021886 BX957147 BM724486 BM474162

AV729269 AU119728 Z38433 CD365228 AU119826 AA164719 AI815582 Z42176

highest scoring ESTs for TANC2:

AA843532 AI690079 AA025036 AA025136 AA036716 AA164719 AA292298 AA300872 AA399200 AA533999

Unigene Cluster for TANC2:

Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2

Hs.410889 [show with all ESTs]

Unigene Representative Sequence: NM_025185

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000389520

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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TANC2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TANC2

¹ / ² / ³

9 probe-sets matching TANC2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32355_at²^{, 3}	U95-A	1	1.00	1.00	0.25	0.84	AL050270	0.40	1.00	0.76	1
52995_at²^{, 3}	U95-B	1	1.00	1.00	0.93	1.28	AA843532	1.00	1.00	1.00	1
86527_at²^{, 3}	U95-E	1	0.94	1.00	0.95	0.90	AI690079	1.00	1.00	1.00	1
208425_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_015623	0.20	1.00	0.72	1
224952_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BF115054	0.80	1.00	0.91	1
231799_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AK021886	0.40	1.00	0.76	1
208425_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
224952_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
231799_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks TANC2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TATACAGATT

SOURCE GeneReport for Unigene cluster: Hs.410889

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TANC2 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TANC2¹	--	tetratricopeptide repeat, ankyrin repeat and coiled-coil more	93.53(n) 98.88(a)	480483 XM_845104.1 XP_850197.1
chimpanzee (Pan troglodytes)	TANC2¹	--	tetratricopeptide repeat, ankyrin repeat and coiled-coil more	99.66(n) 99.64(a)	454784 XM_511597.2 XP_511597.2
cow (Bos taurus)	TANC2¹	--	tetratricopeptide repeat, ankyrin repeat and coiled-coil more	91.47(n) 98.14(a)	529494 XM_607943.3 XP_607943.3
rat (Rattus norvegicus)	RGD1309285¹	--	similar to KIAA1636 protein	92.06(n) 97.99(a)	303599 XM_221028.4 XP_221028.4
mouse (Mus musculus)	Tanc2^{1, 5}	11⁵	tetratricopeptide repeat, ankyrin repeat and coiled-coil more^{1, 5}	92.28(n)¹ 98.34(a)¹	77097¹ NM_181071.3¹ NP_851416.2¹ AI195403⁵ AI413677⁵ (see all 27)

About this table Species with no ortholog for TANC2

ENSEMBL Gene Tree for TANC2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TANC2 gene

TANC1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1310 NCBI SNPs in TANC2 are shown (see all 1310 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 183)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs1509822^1,2	C,F,H,O	58439716(-)	`TTAATT/ACTTTT`	1	--	ng5¹		7	EU EA WA NA	558
	rs9889828^1,2	F,H	58859232(+)	`CCTACC/TAAAGC`	1	--	ng3¹		4	EU EA WA	418
	rs17631249^1,2	F,H	58854310(+)	`AGACGC/GAGCAA`	1	--	ut3¹		7	NA EU EA WA	562
	rs8072447^1,2	H	58856670(+)	`CTAGGT/CGTCAC`	1	--	ut3¹		4	EU EA WA	416
	rs2460111^1,2	A,C,F,H,O	58669004(-)	`TGAGAT/CTGCCA`	1	Q/Q	syn¹		4	EU EA WA	404
	rs1518778^1,2	A,C,F,H,O	58701161(+)	`CTAAAC/TGGTTA`	1	--	int¹		10	EU EA WA NA	828
	rs2429427^1,2	A,C,F,H,O	58747548(+)	`CAAAAG/ATTTAT`	1	--	int¹		11	EU EA WA NA	970
	rs2447448^1,2	A,C,F,H,O	58740470(+)	`TACATA/GCCAAA`	1	--	int¹		5	EU EA NA	336
	rs930528^1,2	A,C,F,H,O	58680003(+)	`TATGAC/GATAAA`	1	--	int¹		12	NS EU EA WA NA	656
	rs2907466^1,2	A,C,F,H,O	58740187(+)	`TGTCTA/GTGTAA`	1	--	int¹		9	EU EA WA NA	742

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HapMap Linkage Disequilibrium images for TANC2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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7 PubMed articles for TANC2 gene:

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)^{3, 4} Nagase T....Ohara O. (2000)
Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PubMed id 10574461)^{3, 4} Hirosawa M....Ohara O. (1999)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)⁴ Olsen J.V....Mann M. (2006)
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)⁴ Zody M.C.... Nusbaum C. (2006)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)⁴ Beausoleil S.A....Gygi S.P. (2004)
Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)⁴ Brill L.M....Peters E.C. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 26115	HGNC: 30212	AceView: DKFZP564D166	Ensembl:ENSG00000170921	euGenes: HUgn26115
ECgene: TANC2	H-InvDB: TANC2

(According to HUGE)
About This Section

HUGE: KIAA1636 KIAA1148

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for TANC2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for TANC2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TANC2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TANC2		Antibodies for TANC2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TANC2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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Search Tocris compounds for TANC2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for TANC2

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TANC2 Gene

protein-coding GIFtS: 43

Aliases &
Descriptions
for TANC2

Summaries
for TANC2

Genomic Location
for TANC2

Proteins
for TANC2

Protein Domains/
Families
for TANC2

Gene Function
for TANC2

Pathways & Interactions
for TANC2

Drugs & Compounds
for TANC2

Transcripts
for TANC2

Expression
for TANC2

Orthologs
for TANC2

Paralogs
for TANC2

SNPs/Variants
for TANC2

Disorders & Mutations
for TANC2

Medical News
for TANC2

Publications
for TANC2

Search for TANC2

Genome Databases showing TANC2

Other Databases showing TANC2

Specialized Databases showing TANC2

Licensable Technologies
for TANC2

Services
for TANC2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TANC2 Gene

protein-coding GIFtS: 43

Aliases & Descriptionsfor TANC2

Summariesfor TANC2

Genomic Locationfor TANC2

Proteinsfor TANC2

Protein Domains/Familiesfor TANC2

Gene Functionfor TANC2

Pathways & Interactionsfor TANC2

Drugs & Compoundsfor TANC2

Transcriptsfor TANC2

Expression for TANC2

Orthologsfor TANC2

Paralogsfor TANC2

SNPs/Variantsfor TANC2

Disorders & Mutationsfor TANC2

Medical Newsfor TANC2

Publicationsfor TANC2

Search for TANC2

Genome Databases showing TANC2

Other Databases showing TANC2

Specialized Databases showing TANC2

Licensable Technologiesfor TANC2

Servicesfor TANC2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TANC2

Summaries
for TANC2

Genomic Location
for TANC2

Proteins
for TANC2

Protein Domains/
Families
for TANC2

Gene Function
for TANC2

Pathways & Interactions
for TANC2

Drugs & Compounds
for TANC2

Transcripts
for TANC2

Expression
for TANC2

Orthologs
for TANC2

Paralogs
for TANC2

SNPs/Variants
for TANC2

Disorders & Mutations
for TANC2

Medical News
for TANC2

Publications
for TANC2

Licensable Technologies
for TANC2

Services
for TANC2