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Aliases for TANC2 Gene

Aliases for TANC2 Gene

  • Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Containing 2 2 3 5
  • Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Domain-Containing Protein 2 3 4
  • Putative Ankyrin-Repeat Containing Protein 3
  • Rolling Pebbles Homolog B (Drosophila) 2
  • Rolling Pebbles Homolog B 3
  • Protein TANC2 3
  • KIAA1148 4
  • KIAA1636 4
  • ROLSA 3
  • Rols 3

External Ids for TANC2 Gene

Previous GeneCards Identifiers for TANC2 Gene

  • GC17P058397
  • GC17P058625
  • GC17P061086
  • GC17P056455

Summaries for TANC2 Gene

GeneCards Summary for TANC2 Gene

TANC2 (Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Containing 2) is a Protein Coding gene. Diseases associated with TANC2 include Oral Hairy Leukoplakia. An important paralog of this gene is TANC1.

Additional gene information for TANC2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TANC2 Gene

Genomics for TANC2 Gene

GeneHancer (GH) Regulatory Elements for TANC2 Gene

Promoters and enhancers for TANC2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I062965 Promoter/Enhancer 1.5 Ensembl ENCODE 557.7 +0.5 509 4.2 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 IRF4 ZNF766 TANC2 ENSG00000283538 ENSG00000266411 CYB561 TLK2 DDX42 ENSG00000265971
GH17I063009 Promoter 0.7 EPDnew 550.3 +42.9 42856 0.1 MNT NFXL1 TANC2 ENSG00000272164 GC17P062996 LOC100419888
GH17I062964 Enhancer 0.2 ENCODE 550.8 -1.7 -1669 0.2 TANC2 ENSG00000283538 TRMT112P3
GH17I062818 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 7 -144.4 -144429 7.4 HDGF PKNOX1 NEUROD1 SIN3A YBX1 ZBTB7B ETS1 E2F8 ZNF207 ZNF143 MED13 TLK2 DDX42 RPS10P26 TANC2 GC17P062830 LOC101927877
GH17I063273 Enhancer 1.4 FANTOM5 Ensembl ENCODE 5.3 +309.2 309204 4.8 PKNOX1 INSM2 NFXL1 RAD21 RFX5 ZEB1 ZNF335 ZNF366 RCOR1 FOS CYB561 ENSG00000265282 TANC2 KCNH6 MAP3K3 LIMD2 GC17M063258 GC17P063302 ENSG00000233635
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TANC2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TANC2 gene promoter:

Genomic Locations for TANC2 Gene

Genomic Locations for TANC2 Gene
461,043 bases
Plus strand

Genomic View for TANC2 Gene

Genes around TANC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TANC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TANC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TANC2 Gene

Proteins for TANC2 Gene

  • Protein details for TANC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein TANC2
    Protein Accession:
    Secondary Accessions:
    • Q9HAC3
    • Q9NW88
    • Q9NXY9
    • Q9ULS2

    Protein attributes for TANC2 Gene

    1990 amino acids
    Molecular mass:
    219650 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAB92314.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB92314.1; Type=Frameshift; Positions=1221; Evidence={ECO:0000305};

    Alternative splice isoforms for TANC2 Gene


neXtProt entry for TANC2 Gene

Post-translational modifications for TANC2 Gene

  • Glycosylation at posLast=19281928

No data available for DME Specific Peptides for TANC2 Gene

Domains & Families for TANC2 Gene

Suggested Antigen Peptide Sequences for TANC2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TANC family.
  • Belongs to the TANC family.
genes like me logo Genes that share domains with TANC2: view

Function for TANC2 Gene

Phenotypes From GWAS Catalog for TANC2 Gene

genes like me logo Genes that share phenotypes with TANC2: view

Animal Model Products

miRNA for TANC2 Gene

miRTarBase miRNAs that target TANC2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TANC2 Gene

Localization for TANC2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TANC2 gene
Compartment Confidence
cytosol 4
nucleus 2
plasma membrane 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TANC2 Gene

Pathways & Interactions for TANC2 Gene

SuperPathways for TANC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TANC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
genes like me logo Genes that share ontologies with TANC2: view

No data available for Pathways by source and SIGNOR curated interactions for TANC2 Gene

Drugs & Compounds for TANC2 Gene

(1) Drugs for TANC2 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium channel blockers Pharma 2095
genes like me logo Genes that share compounds with TANC2: view

Transcripts for TANC2 Gene

Unigene Clusters for TANC2 Gene

Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TANC2 Gene

No ASD Table

Relevant External Links for TANC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TANC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TANC2 Gene

Protein differential expression in normal tissues from HIPED for TANC2 Gene

This gene is overexpressed in Tlymphocyte (11.7), Bone (11.0), Lung (10.3), Skin (9.0), Fetal Brain (8.6), and Frontal cortex (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TANC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of TANC2 Gene:


SOURCE GeneReport for Unigene cluster for TANC2 Gene:


Evidence on tissue expression from TISSUES for TANC2 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with TANC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TANC2 Gene

Orthologs for TANC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TANC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TANC2 33 34
  • 99.66 (n)
(Canis familiaris)
Mammalia TANC2 33 34
  • 93.58 (n)
(Mus musculus)
Mammalia Tanc2 33 16 34
  • 92.09 (n)
(Monodelphis domestica)
Mammalia TANC2 34
  • 92 (a)
(Rattus norvegicus)
Mammalia Tanc2 33
  • 91.94 (n)
(Bos Taurus)
Mammalia TANC2 33 34
  • 91.39 (n)
(Ornithorhynchus anatinus)
Mammalia TANC2 34
  • 91 (a)
(Gallus gallus)
Aves TANC2 33 34
  • 81.52 (n)
(Anolis carolinensis)
Reptilia TANC2 34
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tanc2 33
  • 75.1 (n)
(Danio rerio)
Actinopterygii TANC2 (1 of 2) 34
  • 74 (a)
tanc2 33 34
  • 68.74 (n)
Dr.8965 33
fruit fly
(Drosophila melanogaster)
Insecta rols 34
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1817 34
  • 42 (a)
-- 34
  • 41 (a)
-- 34
  • 38 (a)
Species where no ortholog for TANC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TANC2 Gene

Gene Tree for TANC2 (if available)
Gene Tree for TANC2 (if available)

Paralogs for TANC2 Gene Pseudogenes for TANC2 Gene

genes like me logo Genes that share paralogs with TANC2: view

Variants for TANC2 Gene

Sequence variations from dbSNP and Humsavar for TANC2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000005085 -- 62,986,542(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000009012 -- 63,030,263(+) A/T genic_upstream_transcript_variant, intron_variant
rs1000017308 -- 63,258,638(+) C/T intron_variant
rs1000023463 -- 63,408,761(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000031228 -- 63,091,177(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TANC2 Gene

Variant ID Type Subtype PubMed ID
dgv5741n54 CNV loss 21841781
dgv5742n54 CNV loss 21841781
dgv580e214 CNV loss 21293372
esv2657672 CNV deletion 23128226
esv27080 CNV loss 19812545
esv3349047 CNV insertion 20981092
esv3436323 CNV insertion 20981092
esv3640982 CNV loss 21293372
esv3640984 CNV gain 21293372
esv3640986 CNV gain 21293372
esv3640990 CNV loss 21293372
esv3640991 CNV loss 21293372
nsv1064059 CNV gain 25217958
nsv1109101 CNV deletion 24896259
nsv112050 CNV insertion 16902084
nsv2116 CNV insertion 18451855
nsv457865 CNV loss 19166990
nsv457866 CNV loss 19166990
nsv457867 CNV loss 19166990
nsv477071 CNV novel sequence insertion 20440878
nsv480262 CNV novel sequence insertion 20440878
nsv526079 CNV gain 19592680
nsv575846 CNV loss 21841781
nsv575848 CNV loss 21841781
nsv575851 CNV loss 21841781
nsv575853 CNV loss 21841781
nsv833509 CNV gain+loss 17160897
nsv954586 CNV deletion 24416366

Variation tolerance for TANC2 Gene

Residual Variation Intolerance Score: 0.325% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.00; 49.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TANC2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TANC2 Gene

Disorders for TANC2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TANC2 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
oral hairy leukoplakia
  • hairy leukoplakia
- elite association - COSMIC cancer census association via MalaCards
Search TANC2 in MalaCards View complete list of genes associated with diseases


  • Note=Defects in TANC2 has been found in a patient with isolated coloboma, a defect of the eye characterized by the absence of ocular structures due to abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Isolated colobomas may be associated with an abnormally small eye (microphthalmia) or small cornea. {ECO:0000269 PubMed:28493397}.

Additional Disease Information for TANC2

genes like me logo Genes that share disorders with TANC2: view

No data available for Genatlas for TANC2 Gene

Publications for TANC2 Gene

  1. Regulation of dendritic spines, spatial memory, and embryonic development by the TANC family of PSD-95-interacting proteins. (PMID: 21068316) Han S … Kim E (The Journal of neuroscience : the official journal of the Society for Neuroscience 2010) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 58
  4. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TANC2 Gene

Sources for TANC2 Gene

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