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Aliases for TANC2 Gene

Aliases for TANC2 Gene

  • Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Containing 2 2 3
  • Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Domain-Containing Protein 2 3 4
  • KIAA1636 4 6
  • Putative Ankyrin-Repeat Containing Protein 3
  • Rolling Pebbles Homolog B (Drosophila) 2
  • Rolling Pebbles Homolog B 3
  • Protein TANC2 3
  • KIAA1148 4
  • ROLSA 3
  • Rols 3

External Ids for TANC2 Gene

Previous GeneCards Identifiers for TANC2 Gene

  • GC17P058397
  • GC17P058625
  • GC17P061086
  • GC17P056455

Summaries for TANC2 Gene

GeneCards Summary for TANC2 Gene

TANC2 (Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Containing 2) is a Protein Coding gene. An important paralog of this gene is TANC1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TANC2 Gene

Genomics for TANC2 Gene

Regulatory Elements for TANC2 Gene

Genomic Location for TANC2 Gene

62,966,552 bp from pter
63,427,706 bp from pter
461,155 bases
Plus strand

Genomic View for TANC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TANC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TANC2 Gene

Proteins for TANC2 Gene

  • Protein details for TANC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein TANC2
    Protein Accession:
    Secondary Accessions:
    • Q9HAC3
    • Q9NW88
    • Q9NXY9
    • Q9ULS2

    Protein attributes for TANC2 Gene

    1990 amino acids
    Molecular mass:
    219650 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAB92314.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB92314.1; Type=Frameshift; Positions=1221; Evidence={ECO:0000305};

    Alternative splice isoforms for TANC2 Gene


neXtProt entry for TANC2 Gene

Proteomics data for TANC2 Gene at MOPED

Post-translational modifications for TANC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TANC2 Gene

No data available for DME Specific Peptides for TANC2 Gene

Domains for TANC2 Gene

Suggested Antigen Peptide Sequences for TANC2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TANC family.
  • Contains 11 ANK repeats.
  • Belongs to the TANC family.
  • Contains 11 ANK repeats.
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with TANC2: view

Function for TANC2 Gene

Gene Ontology (GO) - Molecular Function for TANC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TANC2: view

Phenotypes for TANC2 Gene

MGI mutant phenotypes for TANC2:
inferred from 1 alleles
GenomeRNAi human phenotypes for TANC2:
genes like me logo Genes that share phenotypes with TANC2: view

Animal Model Products

miRNA for TANC2 Gene

miRTarBase miRNAs that target TANC2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TANC2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TANC2 Gene

Localization for TANC2 Gene

Subcellular locations from

Jensen Localization Image for TANC2 Gene COMPARTMENTS Subcellular localization image for TANC2 gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1
mitochondrion 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TANC2 Gene

Pathways for TANC2 Gene

SuperPathways for TANC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TANC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
genes like me logo Genes that share ontologies with TANC2: view

No data available for Pathways by source for TANC2 Gene

Drugs for TANC2 Gene

(1) PharmGKB related drug/compound annotations for TANC2 Gene

Drug/compound Annotation
calcium channel blockers Clinical Annotation
genes like me logo Genes that share compounds with TANC2: view

Transcripts for TANC2 Gene

Unigene Clusters for TANC2 Gene

Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TANC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TANC2 Gene

No ASD Table

Relevant External Links for TANC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TANC2 Gene

mRNA expression in normal human tissues for TANC2 Gene

Protein differential expression in normal tissues for TANC2 Gene

This gene is overexpressed in Tlymphocyte (11.7), Bone (11.0), Lung (10.3), Skin (9.0), Fetal Brain (8.6), and Frontal cortex (7.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TANC2 Gene

SOURCE GeneReport for Unigene cluster for TANC2 Gene Hs.410889

genes like me logo Genes that share expressions with TANC2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for TANC2 Gene

Orthologs for TANC2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TANC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TANC2 35
  • 91.39 (n)
  • 98.04 (a)
TANC2 36
  • 98 (a)
(Canis familiaris)
Mammalia TANC2 35
  • 93.58 (n)
  • 98.59 (a)
TANC2 36
  • 98 (a)
(Mus musculus)
Mammalia Tanc2 35
  • 92.09 (n)
  • 98.04 (a)
Tanc2 16
Tanc2 36
  • 98 (a)
(Pan troglodytes)
Mammalia TANC2 35
  • 99.66 (n)
  • 99.65 (a)
TANC2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tanc2 35
  • 91.94 (n)
  • 97.74 (a)
(Monodelphis domestica)
Mammalia TANC2 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia TANC2 36
  • 91 (a)
(Gallus gallus)
Aves TANC2 35
  • 81.52 (n)
  • 95.03 (a)
TANC2 36
  • 98 (a)
(Anolis carolinensis)
Reptilia TANC2 36
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tanc2 35
  • 75.1 (n)
  • 87.2 (a)
(Danio rerio)
Actinopterygii Dr.8965 35
tanc2 35
  • 68.74 (n)
  • 76.17 (a)
tanc2 36
  • 73 (a)
TANC2 (1 of 2) 36
  • 74 (a)
fruit fly
(Drosophila melanogaster)
Insecta rols 36
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
-- 36
  • 38 (a)
CSA.1817 36
  • 42 (a)
Species with no ortholog for TANC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TANC2 Gene

Gene Tree for TANC2 (if available)
Gene Tree for TANC2 (if available)

Paralogs for TANC2 Gene Pseudogenes for TANC2 Gene

genes like me logo Genes that share paralogs with TANC2: view

Variants for TANC2 Gene

Sequence variations from dbSNP and Humsavar for TANC2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs16715 -- 63,316,296(+) CCAGA(-/AAGCTC)AAGCT intron-variant
rs171309 -- 63,013,295(+) tcagt(A/G)tttta intron-variant
rs190249 -- 63,013,644(+) gtaat(C/T)tcagc intron-variant
rs239356 -- 63,064,456(-) tttca(C/G)atagg intron-variant
rs239357 -- 63,061,621(-) ataca(C/T)ctagt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TANC2 Gene

Variant ID Type Subtype PubMed ID
nsv908681 CNV Loss 21882294
nsv457865 CNV Loss 19166990
nsv526079 CNV Gain 19592680
nsv457866 CNV Loss 19166990
nsv457867 CNV Loss 19166990
nsv2116 CNV Insertion 18451855
nsv112050 CNV Insertion 16902084
esv2657672 CNV Deletion 23128226
esv27080 CNV Loss 19812545
nsv833509 CNV Gain+Loss 17160897
nsv908682 CNV Loss 21882294

Relevant External Links for TANC2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TANC2 Gene

Disorders for TANC2 Gene

Relevant External Links for TANC2

Genetic Association Database (GAD)

No disorders were found for TANC2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TANC2 Gene

Publications for TANC2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 3 4
  3. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration. (PMID: 22360420) Martins-de-Souza D. … Bahn S. (J. Proteome Res. 2012) 3

Products for TANC2 Gene

Sources for TANC2 Gene

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