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Aliases & Descriptions for TANC1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases FLJ13360 2 FLJ41166 2 KIAA1728 1 , 2 , 3 ROLSB 1 , 2 TANC 2
Descriptions TPR domain, ankyrin-repeat and coiled-coil-containing 2 Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1 3 rolling pebbles homolog B 2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 2
Search outside databases for aliases for TANC1 genePrevious GC identifer: GC02P159739
Summaries for TANC1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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UniProtKB/Swiss-Prot: TANC1_HUMAN, Q9C0D5 Function : May be a scaffold component in the postsynaptic density (By similarity)
Genomic Location for TANC1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the TANC1 gene Entrez Gene cytogenetic band: 2q24.1-q24.2 Ensembl cytogenetic band: 2q24.1 HGNC cytogenetic band: 2q24.2 TANC1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02P159533:
(about GC identifiers )
Start:
159,533,392 bp from pter
End:
159,797,416 bp from pter
Size:
264,025 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000002.10 NT_005403.16 Proteins for TANC1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: TANC1_HUMAN, Q9C0D5 (See
protein sequence )Recommended Name: Protein TANC1 Size : 1861 amino acids; 202192 Da
Subunit : Interacts probably directly with DLG1, DLG4, HOMER1. Interacts with DLGAP1, INA, CAMK2A,GRIN2B and GRIA1 (By similarity)
Subcellular location : Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (Bysimilarity)
Sequence caution : Sequence=AAH37329.1; Type=Erroneous initiation; Note=Translation N-terminallyextended; Sequence=AAH37329.1; Type=Miscellaneous discrepancy; Note=The cDNA sequence appears tobe not correctly spliced at its 3'-end;
Secondary accessions : Q49AI8Alternative splicing : 2 isoforms : Q9C0D5-1 Q9C0D5-2
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001139381.1 NP_203752.2 ENSEMBL proteins: ENSP00000263635 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 4 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for TANC1: Assays for TANC1:
Protein
Domains/ Families for TANC1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9C0D5 ProtoNet protein and cluster: Q9C0D5
UniProtKB/Swiss-Prot: TANC1_HUMAN, Q9C0D5 Similarity : Belongs to the TANC familySimilarity : Contains 11 ANK repeatsSimilarity : Contains 3 TPR repeats
Gene Function for TANC1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
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Millipore ,
OriGene , and/or
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siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): XM_043492 Applied Biosystems Silencer ® siRNAs for TANC1 Sigma-Aldrich siRNA for TANC1 Sigma-Aldrich shRNA for TANC1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001145909                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001145909                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001145909  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_033394 UniProtKB/Swiss-Prot: TANC1_HUMAN, Q9C0D5 Function : May be a scaffold component in the postsynaptic density (By similarity)
1 Gene Ontology (GO) molecular function term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005488 binding
IEA --
About this table
Pathways & Interactions for TANC1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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5/7 Interacting proteins for TANC1 (ENSP00000263635 3 ) via UniProtKB, MINT, and/or STRING (see all 7
)About this table
Drugs & Compounds for TANC1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for TANC1
Transcripts for TANC1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): XM_043492 Sigma-Aldrich siRNA for TANC1 Sigma-Aldrich shRNA for TANC1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_033394
REFSEQ mRNAs for TANC1 gene (2 alternative transcripts): NM_001145909.1 NM_033394.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_033394
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001145909                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001145909                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001145909  
Additional cDNA sequence: AB051515.1 AK000401.1 AK023422.1 AK094285.1 AK123161.1 AK128859.1 AK308899.1 AL833258.1 BC037329.1 BC150597.1 BX648238.1 BX648327.1
11 DOTS entries : DT.113986 DT.75105544 DT.40309268 DT.75102900 DT.95349560 DT.40188880 DT.91880496 DT.92432227 DT.100647930 DT.100703749 DT.439489
24/164 AceView cDNA sequences (see all 164
):AA700643 BQ008657 BM970999 AW780332 AA774703 AI554932 BE349247 AA630087 AW188092 AA773835 BU733750 BF435307 AI246536 AI745307 AI080379 CA394398 BX280598 AK128859 Z44594 AW029363 AI681992 BX648327 BQ883307 AK023422
highest scoring ESTs for TANC1 :AI743960 AA203234 AA329611 AA330667 AA371288 AA630087 AA773835 AA774703 AA931054 AB051515
Unigene Cluster for TANC1: Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 Hs.61590 [show with all ESTs ] Unigene Representative Sequence: BX648238 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TANC1 (see all 6
) ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a · SP1 :       -   -                                     -       -   SP2 :       -   -     -   -   -   -   -   -   -   -   -   -   -   -           -       -   SP3 :                                                   -   SP4 :                                                     SP5 :                                                    
ExUns: 21b · 21c ^ 22 ^ 23 SP1 :   -       SP2 :   -       SP3 :         SP4 :         SP5 :        
About this scheme ECgene alternative splicing isoforms for TANC1 1 Ensembl transcript including schematic representation : ENST00000263635
Expression for TANC1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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TANC1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for TANC1 1 / 2 / 3
5 probe-sets matching TANC1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: AGTTTTGCTGSOURCE GeneReport for Unigene cluster: Hs.61590
Orthologs for TANC1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for TANC1 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for TANC1 ENSEMBL Gene Tree for TANC1 Paralogs for TANC1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for TANC1 gene TANC2 2
SNPs/Variants for TANC1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for TANC1 (up to first 250kb)
Disorders & Mutations for TANC1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 611397
Medical News for TANC1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for TANC1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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9 PubMed articles for TANC1 gene : A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins. (PubMed id 15673434) 2, 3 Suzuki T....Endo S. (2005) Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970) 3, 4 Nagase T....Ohara O. (2000) Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336) 4 Cantin G.T....Yates J.R. III (2008) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 4 Dephoure N.... Gygi S.P. (2008) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 3 Kimura K.... Sugano S. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3 Ota T....Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002) Expressed sequence tag analysis of human RPE/choroid for the NEIBank project: over 6000 non-redundant transcripts, novel genes and splice variants. (PubMed id 12107410) 3 Wistow G.... Peterson K. (2002)
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Genome Databases showing TANC1
(According to
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AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing TANC1
(According to HUGE )
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Specialized Databases showing TANC1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for TANC1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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