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Aliases for TANC1 Gene

Aliases for TANC1 Gene

  • Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Containing 1 2 3 5
  • Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Domain-Containing Protein 1 3 4
  • TPR Domain, Ankyrin-Repeat And Coiled-Coil-Containing 3
  • Rolling Pebbles Homolog B (Drosophila) 2
  • Rolling Pebbles Homolog B 3
  • Protein TANC1 3
  • KIAA1728 4
  • ROLSB 3
  • TANC 3

External Ids for TANC1 Gene

Previous GeneCards Identifiers for TANC1 Gene

  • GC02P159739
  • GC02P159533
  • GC02P151714
  • GC02P159825

Summaries for TANC1 Gene

GeneCards Summary for TANC1 Gene

TANC1 (Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Containing 1) is a Protein Coding gene. An important paralog of this gene is TANC2.

UniProtKB/Swiss-Prot for TANC1 Gene

  • May be a scaffold component in the postsynaptic density.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TANC1 Gene

Genomics for TANC1 Gene

Regulatory Elements for TANC1 Gene

Enhancers for TANC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G159029 1.8 VISTA Ensembl ENCODE dbSUPER 18.4 +62.4 62355 3.0 HDAC1 NFIB SIN3A RAD21 GATA2 FOS NR2F2 NFIC SMARCA4 PBX2 TANC1 OR7E89P GC02M159029 RNU6-580P GSTM3P2
GH02G159088 1.3 Ensembl ENCODE dbSUPER 24.3 +123.4 123440 6.5 CTCF PKNOX1 NFIB JUN ZIC2 ZBTB40 RAD21 GATA2 ZSCAN5C ZNF600 TANC1 OR7E89P OR7E28P GSTM3P2 MIR6888
GH02G159096 1.4 Ensembl ENCODE dbSUPER 19.7 +130.0 130014 4.4 CBX3 NFIB RAD21 GATA2 ZNF366 FOS MIXL1 SMARCC1 USF2 CEBPB TANC1 OR7E28P GSTM3P2 MIR6888
GH02G159122 1.5 Ensembl ENCODE dbSUPER 16.5 +156.1 156094 3.6 FOXA2 FEZF1 ZNF2 GLIS2 GATA2 KLF7 FOS ZNF263 ZNF518A ZNF592 TANC1 RNU2-21P CCDC148 WDSUB1 MIR6888 GSTM3P2
GH02G159044 1 ENCODE dbSUPER 21.8 +76.2 76174 1.4 HDGF MAX RAD21 ZIC2 EED SMC3 RELB IKZF2 CREM ZNF263 TANC1 OR7E89P GSTM3P2 RNU6-580P GC02M159029
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TANC1 on UCSC Golden Path with GeneCards custom track

Promoters for TANC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000125108 566 2801 SIN3A ZNF2 ZNF48 YY1 GLIS2 GATA2 FOS SP5 NFYC REST

Genomic Location for TANC1 Gene

Chromosome:
2
Start:
158,968,634 bp from pter
End:
159,232,663 bp from pter
Size:
264,030 bases
Orientation:
Plus strand

Genomic View for TANC1 Gene

Genes around TANC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TANC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TANC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TANC1 Gene

Proteins for TANC1 Gene

  • Protein details for TANC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0D5-TANC1_HUMAN
    Recommended name:
    Protein TANC1
    Protein Accession:
    Q9C0D5
    Secondary Accessions:
    • C9JD88
    • Q49AI8

    Protein attributes for TANC1 Gene

    Size:
    1861 amino acids
    Molecular mass:
    202219 Da
    Quaternary structure:
    • Interacts probably directly with DLG1, DLG4, HOMER1. Interacts with DLGAP1, INA, CAMK2A, GRIN2B and GRIA1 (By similarity). Interacts with TNIK. Interacts with MINK1 (By similarity).
    SequenceCaution:
    • Sequence=AAH37329.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH37329.1; Type=Miscellaneous discrepancy; Note=The cDNA sequence appears to be not correctly spliced at its 3-end.; Evidence={ECO:0000305};

    Alternative splice isoforms for TANC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TANC1 Gene

Post-translational modifications for TANC1 Gene

  • Phosphorylated; by MINK1 and TNIK upon stimulation by RAP2A.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TANC1 Gene

Domains & Families for TANC1 Gene

Suggested Antigen Peptide Sequences for TANC1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9C0D5

UniProtKB/Swiss-Prot:

TANC1_HUMAN :
  • Belongs to the TANC family.
Family:
  • Belongs to the TANC family.
genes like me logo Genes that share domains with TANC1: view

Function for TANC1 Gene

Molecular function for TANC1 Gene

UniProtKB/Swiss-Prot Function:
May be a scaffold component in the postsynaptic density.
genes like me logo Genes that share phenotypes with TANC1: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TANC1 Gene

Localization for TANC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TANC1 Gene

Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TANC1 gene
Compartment Confidence
cytosol 4
plasma membrane 3
nucleus 3

Gene Ontology (GO) - Cellular Components for TANC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with TANC1: view

Pathways & Interactions for TANC1 Gene

SuperPathways for TANC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TANC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007520 myoblast fusion IEA --
GO:0008542 visual learning IEA --
GO:0097062 dendritic spine maintenance IEA --
genes like me logo Genes that share ontologies with TANC1: view

No data available for Pathways by source and SIGNOR curated interactions for TANC1 Gene

Drugs & Compounds for TANC1 Gene

(1) Drugs for TANC1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
radiotherapy Pharma 0
genes like me logo Genes that share compounds with TANC1: view

Transcripts for TANC1 Gene

Unigene Clusters for TANC1 Gene

Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TANC1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a ·
SP1: - - - -
SP2: - - - - - - - - - - - - - - - -
SP3: -
SP4:
SP5:
SP6:

ExUns: 21b · 21c ^ 22 ^ 23
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:

Relevant External Links for TANC1 Gene

GeneLoc Exon Structure for
TANC1
ECgene alternative splicing isoforms for
TANC1

Expression for TANC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TANC1 Gene

Protein differential expression in normal tissues from HIPED for TANC1 Gene

This gene is overexpressed in Serum (16.6), Retina (11.6), Heart (9.5), and Testis (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TANC1 Gene



NURSA nuclear receptor signaling pathways regulating expression of TANC1 Gene:

TANC1

SOURCE GeneReport for Unigene cluster for TANC1 Gene:

Hs.61590

Evidence on tissue expression from TISSUES for TANC1 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with TANC1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TANC1 Gene

Orthologs for TANC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TANC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TANC1 34 35
  • 99.49 (n)
dog
(Canis familiaris)
Mammalia TANC1 34 35
  • 90.51 (n)
cow
(Bos Taurus)
Mammalia TANC1 34 35
  • 87.35 (n)
mouse
(Mus musculus)
Mammalia Tanc1 34 16 35
  • 86.17 (n)
rat
(Rattus norvegicus)
Mammalia Tanc1 34
  • 85.54 (n)
oppossum
(Monodelphis domestica)
Mammalia TANC1 35
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TANC1 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves TANC1 34 35
  • 71.41 (n)
lizard
(Anolis carolinensis)
Reptilia TANC1 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tanc1 34
  • 66.8 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100334650 34
  • 66.05 (n)
TANC1 (2 of 2) 35
  • 65 (a)
OneToMany
tanc1a 35
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta rols 35
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1817 35
  • 43 (a)
ManyToMany
-- 35
  • 39 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
Species where no ortholog for TANC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TANC1 Gene

ENSEMBL:
Gene Tree for TANC1 (if available)
TreeFam:
Gene Tree for TANC1 (if available)

Paralogs for TANC1 Gene

(5) SIMAP similar genes for TANC1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TANC1: view

Variants for TANC1 Gene

Sequence variations from dbSNP and Humsavar for TANC1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10497203 drug-response 158,994,911(+) ACTAA(A/C)GGTGT intron-variant
rs264588 drug-response 159,079,879(-) AATAG(A/G/T)GGCAA intron-variant
rs264631 drug-response 159,094,353(+) GCTTT(C/G)CAAGT intron-variant
rs264651 drug-response 159,072,919(-) GAAGC(C/T)GGGAG intron-variant
rs6432512 drug-response 159,043,401(+) AGGGA(C/T)GTGCT intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TANC1 Gene

Variant ID Type Subtype PubMed ID
dgv1173e212 CNV loss 25503493
dgv1174e212 CNV loss 25503493
dgv1175e212 CNV gain 25503493
dgv28n50 CNV loss 21212237
dgv4096n100 CNV gain 25217958
dgv478n27 CNV gain 19166990
dgv671n67 CNV gain+loss 20364138
esv1007408 CNV deletion 20482838
esv1033253 CNV deletion 17803354
esv2675252 CNV deletion 23128226
esv2721030 CNV deletion 23290073
esv29829 CNV gain 19812545
esv3302850 CNV tandem duplication 20981092
esv3344311 CNV insertion 20981092
esv33791 CNV gain 17666407
esv3584120 CNV loss 25503493
esv3584127 CNV loss 25503493
esv3584130 CNV loss 25503493
esv3593094 CNV loss 21293372
esv3593095 CNV gain 21293372
esv3593100 CNV gain 21293372
esv3593101 CNV loss 21293372
esv3593102 CNV gain 21293372
esv3593103 CNV loss 21293372
esv3593104 CNV loss 21293372
esv3593105 CNV gain 21293372
esv3593107 CNV loss 21293372
esv3593109 CNV gain 21293372
esv3593110 CNV loss 21293372
nsv1001024 CNV gain 25217958
nsv1006676 CNV gain 25217958
nsv1008665 CNV gain 25217958
nsv1010774 CNV gain 25217958
nsv1011598 CNV gain 25217958
nsv1072039 CNV deletion 25765185
nsv1118073 CNV deletion 24896259
nsv1122012 CNV deletion 24896259
nsv1123403 CNV deletion 24896259
nsv1150125 CNV deletion 26484159
nsv2993 CNV insertion 18451855
nsv433277 CNV loss 18776910
nsv475263 CNV novel sequence insertion 20440878
nsv475568 CNV novel sequence insertion 20440878
nsv475834 CNV novel sequence insertion 20440878
nsv514100 CNV loss 21397061
nsv518893 CNV gain 19592680
nsv524373 CNV loss 19592680
nsv583449 CNV gain 21841781
nsv583472 CNV loss 21841781
nsv583473 CNV loss 21841781
nsv583474 CNV loss 21841781
nsv583475 CNV loss 21841781
nsv819030 CNV gain 19587683
nsv820838 CNV deletion 20802225
nsv821769 CNV loss 20364138
nsv955271 CNV deletion 24416366
nsv961902 CNV duplication 23825009

Variation tolerance for TANC1 Gene

Residual Variation Intolerance Score: 4.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.74; 78.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TANC1 Gene

Human Gene Mutation Database (HGMD)
TANC1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TANC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TANC1 Gene

Disorders for TANC1 Gene

Relevant External Links for TANC1

Genetic Association Database (GAD)
TANC1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TANC1

No disorders were found for TANC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TANC1 Gene

Publications for TANC1 Gene

  1. Drosophila and mammalian models uncover a role for the myoblast fusion gene TANC1 in rhabdomyosarcoma. (PMID: 22182840) Avirneni-Vadlamudi U. … Galindo R.L. (J. Clin. Invest. 2012) 2 3 64
  2. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat B.E. … Tseng Z.H. (BMC Cardiovasc Disord 2011) 3 46 64
  3. A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins. (PMID: 15673434) Suzuki T. … Endo S. (Eur. J. Neurosci. 2005) 2 3 64
  4. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 64
  5. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3 64

Products for TANC1 Gene

Sources for TANC1 Gene

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