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TANC1 Gene

protein-coding   GIFtS: 46

GC02P159533
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
FLJ13360 2
FLJ41166 2
KIAA1728 1, 2, 3
ROLSB 1, 2
TANC 2
Descriptions
TPR domain, ankyrin-repeat and coiled-coil-containing 2
Tetratricopeptide repeat, ankyrin repeat and coiled-coil
domain-containing protein 1 3
rolling pebbles homolog B 2
tetratricopeptide repeat, ankyrin repeat and coiled-coil
containing 1 2
External Ids
HGNC: 293641
Entrez Gene: 854612
UniProtKB: Q9C0D53
Ensembl: ENSG000001151837
Search outside databases for aliases for TANC1 gene

Previous GC identifer: GC02P159739

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TANC1_HUMAN, Q9C0D5
Function: May be a scaffold component in the postsynaptic density (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the TANC1 gene  

Entrez Gene cytogenetic band: 2q24.1-q24.2   Ensembl cytogenetic band:  2q24.1   HGNC cytogenetic band: 2q24.2

TANC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P159533:     (about GC identifiers)

Start:
159,533,392 bp from pter
End:
159,797,416 bp from pter
Size:
264,025 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000002.10  NT_005403.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TANC1_HUMAN, Q9C0D5 (See protein sequence)
Recommended Name: Protein TANC1  
Size: 1861 amino acids; 202192 Da
Subunit: Interacts probably directly with DLG1, DLG4, HOMER1. Interacts with DLGAP1, INA, CAMK2A,
GRIN2B and GRIA1 (By similarity)
Subcellular location: Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By
similarity)
Sequence caution: Sequence=AAH37329.1; Type=Erroneous initiation; Note=Translation N-terminally
extended; Sequence=AAH37329.1; Type=Miscellaneous discrepancy; Note=The cDNA sequence appears to
be not correctly spliced at its 3'-end;
Secondary accessions: Q49AI8
Alternative splicing: 2 isoforms:  Q9C0D5-1   Q9C0D5-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001139381.1  NP_203752.2  


    ENSEMBL proteins: 
    ENSP00000263635 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
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    Browse Abcam for Recombinant Proteins
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    4 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane IEA--
    GO:0030054 cell junction IEA--
    GO:0045202 synapse IEA--
    GO:0045211 postsynaptic membrane IEA--
    About this table

    Antibodies for TANC1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for TANC1

    Assays for TANC1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    5 InterPro domains/families:
     IPR001440 TPR-1
     IPR011990 TPR-like_helical
     IPR013026 TPR_region
     IPR019734 TPR_repeat
     IPR002110 ANK


       GeneDecks  TANC1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9C0D5

    ProtoNet protein and cluster: Q9C0D5

    UniProtKB/Swiss-Prot: TANC1_HUMAN, Q9C0D5
    Similarity: Belongs to the TANC family
    Similarity: Contains 11 ANK repeats
    Similarity: Contains 3 TPR repeats

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (TANC1)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): XM_043492

                  Applied Biosystems Silencer® siRNAs for TANC1

                  Sigma-Aldrich siRNA for TANC1  
                         Sigma-Aldrich shRNA for TANC1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001145909
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001145909
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001145909 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_033394

    UniProtKB/Swiss-Prot: TANC1_HUMAN, Q9C0D5
    Function: May be a scaffold component in the postsynaptic density (By similarity)

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488 binding IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    5/7 Interacting proteins for TANC1 (ENSP000002636353) via UniProtKB, MINT, and/or STRING (see all 7 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    INAENSP000003588653STRING (score=.936)
    DLGAP1ENSP000003163773STRING (score=.85)
    HOMER1ENSP000003343823STRING (score=.818)
    GRIA1ENSP000002859003STRING (score=.797)
    CAMK2AENSP000003050903STRING (score=.782)
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for TANC1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (TANC1)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): XM_043492

                  Sigma-Aldrich siRNA for TANC1  
                         Sigma-Aldrich shRNA for TANC1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_033394  

    REFSEQ mRNAs for TANC1 gene (2 alternative transcripts): 

    NM_001145909.1   NM_033394.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_033394  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001145909
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001145909
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001145909 

    Additional cDNA sequence: 

    AB051515.1 AK000401.1 AK023422.1 AK094285.1 AK123161.1 AK128859.1 AK308899.1 AL833258.1 
    BC037329.1 BC150597.1 BX648238.1 BX648327.1 

    11 DOTS entries:

    DT.113986  DT.75105544  DT.40309268  DT.75102900  DT.95349560  DT.40188880  DT.91880496  DT.92432227 
    DT.100647930  DT.100703749  DT.439489 

    24/164 AceView cDNA sequences (see all 164 ):

    AA700643 BQ008657 BM970999 AW780332 AA774703 AI554932 BE349247 AA630087 
    AW188092 AA773835 BU733750 BF435307 AI246536 AI745307 AI080379 CA394398 
    BX280598 AK128859 Z44594 AW029363 AI681992 BX648327 BQ883307 AK023422 

    highest scoring ESTs for TANC1:

    AI743960 AA203234 AA329611 AA330667 AA371288 AA630087 AA773835 AA774703 AA931054 AB051515 

    Unigene Cluster for TANC1:

    Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
    Hs.61590  [show with all ESTs]
    Unigene Representative Sequence: BX648238


    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TANC1 (see all 6 )

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a ·
    SP1:                    -     -                                                                                                           -                 -   
    SP2:                    -     -           -     -     -     -     -     -     -     -     -     -     -     -                             -                 -   
    SP3:                                                                                                                                                        -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21b · 21c ^ 22 ^ 23
    SP1:        -               
    SP2:        -               
    SP3:                        
    SP4:                        
    SP5:                        

    About this scheme

    ECgene alternative splicing isoforms for TANC1

    1 Ensembl transcript including schematic representation:
    ENST00000263635  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    TANC1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for TANC1

    1 / 2 / 3

    5 probe-sets matching TANC1 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    50242_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AI743960 1.00 1.00 1.00 1

    225308_s_at2, 3 U133-B 1 1.00 1.00 -- -- AB051515 0.80 1.00 0.91 1

    234039_at2, 3 U133-B 1 1.00 1.00 -- -- AU155524 0.40 1.00 0.76 1

    225308_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    234039_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AGTTTTGCTG

    SOURCE GeneReport for Unigene cluster: Hs.61590
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for TANC1 gene from 5/6 species (see all 6 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    TANC11   -- tetratricopeptide repeat, ankyrin repeat and coiled-coil more 88.42(n)
    91.58(a)
    478760  XM_535925.2  XP_535925.2 
    chimpanzee
    (Pan troglodytes)
    TANC11   -- tetratricopeptide repeat, ankyrin repeat and coiled-coil more 99.53(n)
    99.12(a)
    459678  XM_515847.2  XP_515847.2 
    rat
    (Rattus norvegicus)
    Tanc11   -- tetratricopeptide repeat, ankyrin repeat and coiled-coil more 85.58(n)
    88.64(a)
    311055  NM_001002854.1  NP_001002854.1 
    mouse
    (Mus musculus)
    Tanc11, 5 25
    tetratricopeptide repeat, ankyrin repeat and coiled-coil more1, 5 86.17(n)1
    89.82(a)1
    668601  NM_198294.21  NP_938036.21 
     AA5914205  AA6234915  (see all 25)
    chicken
    (Gallus gallus)
    TANC11   -- tetratricopeptide repeat, ankyrin repeat and coiled-coil more 71.15(n)
    74.17(a)
    424330  XM_422174.2  XP_422174.2 
    About this table        Species with no ortholog for TANC1

    ENSEMBL Gene Tree for TANC1
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for TANC1 gene
    TANC22  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/1609 NCBI SNPs in TANC1 are shown (see all 1609 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 498)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs10655941,2
    A,C,F,H159797039(+) TTAAAA/GTGCTA 1 -- ut3114Minor allele frequency- G:0.31EA MN EU WA NA 2856
    rs38213011,2
    A,C,F,H159795781(-) TGGGGC/ATTTCT 1 -- ut31 ese38Minor allele frequency- A:0.26EU EA WA 836
    --
    rs46642771,2
    A,C,F,H159794899(+) GCTGCA/CA    
       
    /G/TG
    CTCCT
    3 A/A fra1 mis1 ese34EU EA WA 412
    --
    rs134210841,2
    C,F,H159794714(+) GAATCG/AGCAAG 1 S/G mis14Minor allele frequency- A:0.19EU EA WA 404
    rs8420731,2
    A,C,F159532819(-) ATCTCG/ACCGGC 1 -- ng511Minor allele frequency- A:0.15MN 184
    rs8420741,2
    A,F,H159532391(-) TTGACG/CAAGGA 1 -- ng517Minor allele frequency- C:0.34NA EA EU WA 670
    rs124665511,2
    C,F,H159728109(+) TGGAAG/ACCTAA 1 N/S mis111Minor allele frequency- A:0.02NA EU EA WA 982
    rs8420751,2
    A,C,F159532173(-) CCCTAT/CATAAA 1 -- ng517Minor allele frequency- C:0.28NA EA MN 688
    rs168435361,2
    F,H159565888(+) GAGAAA/GATTGT 1 -- ut517Minor allele frequency- G:0.10NA EU EA WA 558
    rs67208401,2
    A,C159796061(+) CTTTCC/TTCCTT 1 -- ut31 trp30--------
    About this table

    HapMap Linkage Disequilibrium images for TANC1 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 611397

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    9 PubMed articles for TANC1 gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 85461 HGNC: 29364 AceView: TANC Ensembl:ENSG00000115183 euGenes: HUgn85461
    ECgene: TANC1 H-InvDB: TANC1
    (According to HUGE)
    About This Section

    HUGE: KIAA1728
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for TANC1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for TANC1 Browse antibodies at Sigma-Aldrich
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     Lentivirus-delivered shRNAs for TANC1 Browse small molecules at Sigma-Aldrich
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     Search Novus for antibodies for TANC1

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