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Aliases for TANC1 Gene

Aliases for TANC1 Gene

  • Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Containing 1 2 3 5
  • Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Domain-Containing Protein 1 3 4
  • TPR Domain, Ankyrin-Repeat And Coiled-Coil-Containing 3
  • Rolling Pebbles Homolog B (Drosophila) 2
  • Rolling Pebbles Homolog B 3
  • KIAA1728 4
  • ROLSB 3
  • TANC 3

External Ids for TANC1 Gene

Previous GeneCards Identifiers for TANC1 Gene

  • GC02P159739
  • GC02P159533
  • GC02P151714
  • GC02P159825

Summaries for TANC1 Gene

GeneCards Summary for TANC1 Gene

TANC1 (Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Containing 1) is a Protein Coding gene. An important paralog of this gene is ANKRD52.

UniProtKB/Swiss-Prot for TANC1 Gene

  • May be a scaffold component in the postsynaptic density.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TANC1 Gene

Genomics for TANC1 Gene

Regulatory Elements for TANC1 Gene

Enhancers for TANC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TANC1 on UCSC Golden Path with GeneCards custom track

Promoters for TANC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TANC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TANC1 Gene

158,968,634 bp from pter
159,232,663 bp from pter
264,030 bases
Plus strand

Genomic View for TANC1 Gene

Genes around TANC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TANC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TANC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TANC1 Gene

Proteins for TANC1 Gene

  • Protein details for TANC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein TANC1
    Protein Accession:
    Secondary Accessions:
    • C9JD88
    • Q49AI8

    Protein attributes for TANC1 Gene

    1861 amino acids
    Molecular mass:
    202219 Da
    Quaternary structure:
    • Interacts probably directly with DLG1, DLG4, HOMER1. Interacts with DLGAP1, INA, CAMK2A, GRIN2B and GRIA1 (By similarity). Interacts with TNIK. Interacts with MINK1 (By similarity).
    • Sequence=AAH37329.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH37329.1; Type=Miscellaneous discrepancy; Note=The cDNA sequence appears to be not correctly spliced at its 3-end.; Evidence={ECO:0000305};

    Alternative splice isoforms for TANC1 Gene


neXtProt entry for TANC1 Gene

Proteomics data for TANC1 Gene at MOPED

Post-translational modifications for TANC1 Gene

  • Phosphorylated; by MINK1 and TNIK upon stimulation by RAP2A.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TANC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TANC1 Gene

Domains & Families for TANC1 Gene

Suggested Antigen Peptide Sequences for TANC1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TANC family.
  • Contains 11 ANK repeats.
  • Belongs to the TANC family.
  • Contains 11 ANK repeats.
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with TANC1: view

Function for TANC1 Gene

Molecular function for TANC1 Gene

UniProtKB/Swiss-Prot Function:
May be a scaffold component in the postsynaptic density.
genes like me logo Genes that share phenotypes with TANC1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TANC1 Gene

Localization for TANC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TANC1 Gene

Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.

Subcellular locations from

Jensen Localization Image for TANC1 Gene COMPARTMENTS Subcellular localization image for TANC1 gene
Compartment Confidence
cytosol 4
nucleus 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TANC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014069 postsynaptic density IEA --
GO:0030054 cell junction IEA --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with TANC1: view

Pathways & Interactions for TANC1 Gene

SuperPathways for TANC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TANC1 Gene


No data available for Pathways by source and SIGNOR curated interactions for TANC1 Gene

Drugs & Compounds for TANC1 Gene

(1) Drugs for TANC1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
radiotherapy Pharma 0
genes like me logo Genes that share compounds with TANC1: view

Transcripts for TANC1 Gene

Unigene Clusters for TANC1 Gene

Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TANC1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a ·
SP1: - - - -
SP2: - - - - - - - - - - - - - - - -
SP3: -

ExUns: 21b · 21c ^ 22 ^ 23
SP1: -
SP2: -

Relevant External Links for TANC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TANC1 Gene

mRNA expression in normal human tissues for TANC1 Gene

Protein differential expression in normal tissues from HIPED for TANC1 Gene

This gene is overexpressed in Serum (16.6), Retina (11.6), Heart (9.5), and Testis (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TANC1 Gene

SOURCE GeneReport for Unigene cluster for TANC1 Gene Hs.61590

genes like me logo Genes that share expression patterns with TANC1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TANC1 Gene

Orthologs for TANC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TANC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TANC1 35
  • 87.35 (n)
  • 89.5 (a)
TANC1 36
  • 89 (a)
(Canis familiaris)
Mammalia TANC1 35
  • 90.51 (n)
  • 94.41 (a)
TANC1 36
  • 94 (a)
(Mus musculus)
Mammalia Tanc1 35
  • 86.17 (n)
  • 89.76 (a)
Tanc1 16
Tanc1 36
  • 90 (a)
(Pan troglodytes)
Mammalia TANC1 35
  • 99.49 (n)
  • 99.07 (a)
TANC1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tanc1 35
  • 85.54 (n)
  • 88.59 (a)
(Monodelphis domestica)
Mammalia TANC1 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia TANC1 36
  • 78 (a)
(Gallus gallus)
Aves TANC1 35
  • 71.41 (n)
  • 74.31 (a)
TANC1 36
  • 73 (a)
(Anolis carolinensis)
Reptilia TANC1 36
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tanc1 35
  • 66.8 (n)
  • 68.06 (a)
(Danio rerio)
Actinopterygii LOC100334650 35
  • 66.05 (n)
  • 67.95 (a)
TANC1 (2 of 2) 36
  • 65 (a)
tanc1a 36
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta rols 36
  • 29 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 39 (a)
-- 36
  • 34 (a)
CSA.1817 36
  • 43 (a)
Species with no ortholog for TANC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TANC1 Gene

Gene Tree for TANC1 (if available)
Gene Tree for TANC1 (if available)

Paralogs for TANC1 Gene

(5) SIMAP similar genes for TANC1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TANC1: view

Variants for TANC1 Gene

Sequence variations from dbSNP and Humsavar for TANC1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs12466551 - 159,163,352(+) TGGAA(A/G)CCTAA intron-variant, reference, missense, utr-variant-5-prime
rs13421084 - 159,229,957(+) GAATC(A/G)GCAAG reference, missense, utr-variant-3-prime
VAR_038437 -
rs34588551 - 159,097,663(+) CTTCT(C/T)CAGTC reference, missense
rs364506 -- 159,118,017(-) cagTA(C/G)AGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TANC1 Gene

Variant ID Type Subtype PubMed ID
dgv478n27 CNV Gain 19166990
nsv524373 CNV Loss 19592680
nsv518893 CNV Gain 19592680
nsv2993 CNV Insertion 18451855
dgv28n50 CNV Loss 21212237
esv2721030 CNV Deletion 23290073
esv1033253 CNV Deletion 17803354
esv1007408 CNV Deletion 20482838
nsv819030 CNV Gain 19587683
nsv433277 CNV Loss 18776910
esv29829 CNV Gain 19812545
dgv671n67 CNV Gain+Loss 20364138
nsv820838 CNV Deletion 20802225
nsv514100 CNV Loss 21397061
nsv821769 CNV Loss 20364138
esv270687 CNV Insertion 20981092
esv2675252 CNV Deletion 23128226
esv259824 OTHER Complex 20981092
esv33791 CNV Gain 17666407

Variation tolerance for TANC1 Gene

Residual Variation Intolerance Score: 4.11% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.74; 78.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TANC1 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TANC1 Gene

Disorders for TANC1 Gene

Relevant External Links for TANC1

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TANC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TANC1 Gene

Publications for TANC1 Gene

  1. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat B.E. … Tseng Z.H. (BMC Cardiovasc Disord 2011) 3 48 67
  2. A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins. (PMID: 15673434) Suzuki T. … Endo S. (Eur. J. Neurosci. 2005) 2 3
  3. Substrate trapping proteomics reveals targets of the I^TrCP2/FBXW11 ubiquitin ligase. (PMID: 25332235) Kim T.Y. … Major M.B. (Mol. Cell. Biol. 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for TANC1 Gene

Sources for TANC1 Gene