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TANC1 Gene

protein-coding   GIFtS: 48
GCID: GC02P159825

Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil...

  Search for TANC1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Containing
11 2
     Protein TANC12
Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Domain-Containing
Protein 12 3
     Rolling Pebbles Homolog B2
Rolling Pebbles Homolog B (Drosophila)1     TPR Domain, Ankyrin-Repeat And Coiled-Coil-Containing2
ROLSB2     KIAA17283
TANC2     

External Ids:    HGNC: 293641   Entrez Gene: 854612   Ensembl: ENSG000001151837   OMIM: 6113975   UniProtKB: Q9C0D53   

Export aliases for TANC1 gene to outside databases

Previous GC identifers: GC02P159739 GC02P159533 GC02P151714


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TANC1 Gene:
TANC1 (tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1) is a protein-coding gene. An important paralog of this gene is TANC2.

UniProtKB/Swiss-Prot: TANC1_HUMAN, Q9C0D5
Function: May be a scaffold component in the postsynaptic density (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TANC1 gene promoter:
         GCNF   FOXO3   AP-2gamma   FOXO3b   C/EBPalpha   GCNF-1   Sox9   FOXO3a   Cart-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTANC1 promoter sequence
   Search Chromatin IP Primers for TANC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TANC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24.2   Ensembl cytogenetic band:  2q24.2   HGNC cytogenetic band: 2q24.2

TANC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TANC1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P159825:  view genomic region     (about GC identifiers)

Start:
159,825,146 bp from pter      End:
160,089,170 bp from pter
Size:
264,025 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TANC1_HUMAN, Q9C0D5 (See protein sequence)
Recommended Name: Protein TANC1  
Size: 1861 amino acids; 202219 Da
Subunit: Interacts probably directly with DLG1, DLG4, HOMER1. Interacts with DLGAP1, INA, CAMK2A, GRIN2B and GRIA1
(By similarity). Interacts with TNIK. Interacts with MINK1 (By similarity)
Sequence caution: Sequence=AAH37329.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH37329.1; Type=Miscellaneous discrepancy; Note=The cDNA sequence appears to be not correctly spliced
at its 3'-end;
Secondary accessions: C9JD88 Q49AI8
Alternative splicing: 2 isoforms:  Q9C0D5-1   Q9C0D5-2   (Incomplete sequence. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TANC1: NX_Q9C0D5

Explore proteomics data for TANC1 at MOPED

Post-translational modifications: 

  • Phosphorylated; by MINK1 and TNIK upon stimulation by RAP2A1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TANC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001139381.1  NP_203752.2  

    ENSEMBL proteins: 
     ENSP00000263635   ENSP00000396339  

    TANC1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TANC1

     
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    Search eBioscience for ELISAs for TANC1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ANKRD: Ankyrin repeat domain containing
    TTC: Tetratricopeptide (TTC) repeat domain containing

    Selected InterPro protein domains (see all 7):
     IPR011990 TPR-like_helical
     IPR027417 P-loop_NTPase
     IPR013105 TPR_2
     IPR020683 Ankyrin_rpt-contain_dom
     IPR013026 TPR-contain_dom

    Graphical View of Domain Structure for InterPro Entry Q9C0D5

    ProtoNet protein and cluster: Q9C0D5

    UniProtKB/Swiss-Prot: TANC1_HUMAN, Q9C0D5
    Similarity: Belongs to the TANC family
    Similarity: Contains 11 ANK repeats
    Similarity: Contains 3 TPR repeats


    Find genes that share domains with TANC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TANC1_HUMAN, Q9C0D5
    Function: May be a scaffold component in the postsynaptic density (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with TANC1           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tanc1):
     behavior/neurological  nervous system 

    Find genes that share phenotypes with TANC1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TANC1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TANC1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TANC1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TANC1

    miRNA
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    Block miRNA regulation of human, mouse, rat TANC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TANC1 (see all 53):
    hsa-miR-142-5p hsa-miR-562 hsa-miR-548k hsa-miR-199a-3p hsa-miR-106a hsa-miR-29a hsa-miR-301a hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidTANC1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TANC1
    Predesigned siRNA for gene silencing in human, mouse, rat TANC1

    Gene Editing
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    OriGene ORF clones in mouse, rat for TANC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TANC1 (NM_001145909)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TANC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TANC1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TANC1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TANC1_HUMAN, Q9C0D5: Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    plasma membrane3
    cytoskeleton2
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0014069postsynaptic density IEA--
    GO:0030054cell junction IEA--
    GO:0030425dendrite IEA--
    GO:0043025neuronal cell body IEA--
    GO:0043679axon terminus IEA--

    Find genes that share ontologies with TANC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TANC1
    Interactions:

        Search GeneGlobe Interaction Network for TANC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TANC1 (Q9C0D53 ENSP000002636354) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTBP607093, ENSP000003499604I2D: score=1 STRING: ENSP00000349960
    CASKO149363, ENSP000003674084I2D: score=1 STRING: ENSP00000367408
    DLG1Q129593, ENSP000003457314I2D: score=1 STRING: ENSP00000345731
    HOMER1Q86YM73, ENSP000003343824I2D: score=1 STRING: ENSP00000334382
    INAQ163523, ENSP000003588654I2D: score=1 STRING: ENSP00000358865
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007520myoblast fusion IEA--
    GO:0008542visual learning IEA--
    GO:0097062dendritic spine maintenance IEA--

    Find genes that share ontologies with TANC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TANC1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TANC1 gene (2 alternative transcripts): 
    NM_001145909.1  NM_033394.2  

    Unigene Cluster for TANC1:

    Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
    Hs.61590  [show with all ESTs]
    Unigene Representative Sequence: BX648238
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263635(uc010zcm.2 uc002uag.3) ENST00000464096(uc002uah.1)
    ENST00000465963 ENST00000470074(uc010fon.3) ENST00000496406 ENST00000454300(uc010fol.1 uc010fom.1)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TANC1 (see all 53):
    hsa-miR-142-5p hsa-miR-562 hsa-miR-548k hsa-miR-199a-3p hsa-miR-106a hsa-miR-29a hsa-miR-301a hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidTANC1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TANC1
    Predesigned siRNA for gene silencing in human, mouse, rat TANC1
    Clone
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    OriGene clones in human, mouse for TANC1 (see all 10)
    OriGene ORF clones in mouse, rat for TANC1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TANC1 (NM_001145909)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TANC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TANC1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TANC1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TANC1
      QuantiTect SYBR Green Assays in human, mouse, rat TANC1
      QuantiFast Probe-based Assays in human, mouse, rat TANC1

    Additional mRNA sequence: 

    AB051515.1 AK000401.1 AK023422.1 AK094285.1 AK123161.1 AK128859.1 AK308899.1 AL833258.1 
    BC037329.1 BC150597.1 BX648238.1 BX648327.1 

    11 DOTS entries:

    DT.113986  DT.75105544  DT.40309268  DT.75102900  DT.95349560  DT.40188880  DT.91880496  DT.92432227 
    DT.100647930  DT.100703749  DT.439489 

    Selected AceView cDNA sequences (see all 164):

    AI554932 CA394398 AA774703 BM970999 AA700643 AW780332 AI246536 BX280598 
    BQ008657 AW029363 AK128859 BE349247 AA773835 BU733750 AI745307 BF435307 
    AW188092 AI080379 AA630087 Z44594 BU596961 BE784874 BF516518 AW271435 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TANC1 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a ·
    SP1:                    -     -                                                                                                           -                 -   
    SP2:                    -     -           -     -     -     -     -     -     -     -     -     -     -     -                             -                 -   
    SP3:                                                                                                                                                        -   
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 21b · 21c ^ 22 ^ 23
    SP1:        -               
    SP2:        -               
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for TANC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TANC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTTTTGCTG
    TANC1 Expression
    About this image

    TANC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TANC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.61590
        Custom PCR Arrays for TANC1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TANC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TANC1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tanc11 , 5 tetratricopeptide repeat, ankyrin repeat and coiled-coil more1, 5 86.17(n)1
    89.76(a)1
      2 (33.93 cM)5
    668601  NM_198294.21  NP_938036.21 
     596120425 
    chicken
    (Gallus gallus)
    Aves TANC11 tetratricopeptide repeat, ankyrin repeat and coiled-coil more 71.41(n)
    74.31(a)
      424330  XM_004943057.1  XP_004943114.1 
    lizard
    (Anolis carolinensis)
    Reptilia TANC16
    tetratricopeptide repeat, ankyrin repeat and coile...
    77(a)
    1 ↔ 1
    GL343379.1(249625-510771)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tanc11 tetratricopeptide repeat, ankyrin repeat and coiled-coil more 66.8(n)
    68.06(a)
      100489566  XM_004917690.1  XP_004917747.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003346501 protein TANC1-like 66.05(n)
    67.95(a)
      100334650  XM_003199255.2  XP_003199303.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta rols6
    rolling pebbles
    29(a)
    1 → many
    3L(12001325-12057959)


    ENSEMBL Gene Tree for TANC1 (if available)
    TreeFam Gene Tree for TANC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TANC1 gene
    TANC22  ANKS32  ANKRD172  ANKRD292  FEM1A2  ANKHD12  FANK12  KIDINS2202  
    ANKHD1-EIF4EBP32  FEM1B2  ANKS62  FEM1C2  
    5 SIMAP similar genes for TANC1 using alignment to 2 protein entries:     TANC1_HUMAN (see all proteins):
    TANC2    DKFZp761E1322    MTPN    ANKRD29    CDKN2C

    Find genes that share paralogs with TANC1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TANC1 (see all 5419)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3705942221,2
    --151797018(+) GTTTG-/TATGTGT 2 -- int10--------
    rs570200541,2
    C--151955702(+) AAAAA-/AA/AAAAAAA
    AA
    /AAAAAAAAAA
    TTTCC
    2 -- int11NA 2
    rs1849553541,2
    --159823157(+) AGTTAC/TTTCTT 2 -- us2k10--------
    rs1409233311,2
    --159823270(+) CTACTG/TAAGGA 2 -- us2k10--------
    rs739668021,2
    C,F--159823341(+) TTCATC/AAAAAA 2 -- us2k12Minor allele frequency- A:0.04WA 120
    rs1896214621,2
    --159823384(+) GAAAAA/GTGTGG 2 -- us2k10--------
    rs1819158851,2
    --159823598(+) GATTTC/TGTTTC 2 -- us2k10--------
    rs587692591,2
    F--159823630(+) TACCAT/CATTTT 2 -- us2k11Minor allele frequency- C:0.01WA 118
    rs1502235731,2
    C--159823858(+) TGTGTA/GGCATT 2 -- us2k10--------
    rs8420751,2
    C,F,A,H--159823927(-) CCCTAT/CATAAA 2 -- us2k126Minor allele frequency- C:0.31NA EA MN NS WA 3030

    HapMap Linkage Disequilibrium report for TANC1 (159825146 - 160075146 bp, first 250kb of TANC1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TANC1 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv820838CNV Deletion20802225
    esv1033253CNV Deletion17803354
    esv2675252CNV Deletion23128226
    esv1007408CNV Deletion20482838
    esv2721030CNV Deletion23290073
    nsv2993CNV Insertion18451855
    esv270687CNV Insertion20981092
    nsv433277CNV Loss18776910
    nsv514100CNV Loss21397061
    nsv821769CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TANC1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611397    OMIM disorders: --


    Find genes that share disorders with TANC1           About GenesLikeMe

    Genetic Association Database (GAD): TANC1

    Export disorders for TANC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TANC1 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with TANC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PubMed id 21658281)1, 4 Aouizerat B.E....Tseng Z.H. (BMC Cardiovasc Disord 2011)
    2. A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins. (PubMed id 15673434)1, 3 Suzuki T....Endo S. (Eur. J. Neurosci. 2005)
    3. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    4. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    5. Complex chromosomal rearrangement in a girl with psychomotor-retardation and a de novo inversion: inv(2)(p15;q24.2). (PubMed id 21739571)1 Granot-Hershkovitz E....Abeliovich D. (Am. J. Med. Genet. A 2011)
    6. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    7. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    8. Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)2 Cantin G.T....Yates J.R. III (J. Proteome Res. 2008)
    9. MINK is a Rap2 effector for phosphorylation of the postsynaptic scaffold protein TANC1. (PubMed id 18930710)2 Nonaka H....Kariya K. (Biochem. Biophys. Res. Commun. 2008)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 85461 HGNC: 29364 AceView: TANC Ensembl:ENSG00000115183 euGenes: HUgn85461
    ECgene: TANC1 H-InvDB: TANC1

    (According to HUGE)
    About This Section

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    HUGE: KIAA1728

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TANC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TANC1 gene:
    Search GeneIP for patents involving TANC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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