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Aliases for TANC1 Gene

Aliases for TANC1 Gene

  • Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Containing 1 2 3
  • Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Domain-Containing Protein 1 3 4
  • TPR Domain, Ankyrin-Repeat And Coiled-Coil-Containing 3
  • Rolling Pebbles Homolog B (Drosophila) 2
  • Rolling Pebbles Homolog B 3
  • Protein TANC1 3
  • KIAA1728 4
  • ROLSB 3
  • TANC 3

External Ids for TANC1 Gene

Summaries for TANC1 Gene

GeneCards Summary for TANC1 Gene

TANC1 (Tetratricopeptide Repeat, Ankyrin Repeat And Coiled-Coil Containing 1) is a Protein Coding gene. An important paralog of this gene is KIDINS220.

UniProtKB/Swiss-Prot for TANC1 Gene

  • May be a scaffold component in the postsynaptic density.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TANC1 Gene

Genomics for TANC1 Gene

Genomic Location for TANC1 Gene

Start:
158,968,634 bp from pter
End:
159,232,659 bp from pter
Size:
264,026 bases
Orientation:
Plus strand

Genomic View for TANC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TANC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TANC1 Gene

Regulatory Elements for TANC1 Gene

Proteins for TANC1 Gene

  • Protein details for TANC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0D5-TANC1_HUMAN
    Recommended name:
    Protein TANC1
    Protein Accession:
    Q9C0D5
    Secondary Accessions:
    • C9JD88
    • Q49AI8

    Protein attributes for TANC1 Gene

    Size:
    1861 amino acids
    Molecular mass:
    202219 Da
    Quaternary structure:
    • Interacts probably directly with DLG1, DLG4, HOMER1. Interacts with DLGAP1, INA, CAMK2A, GRIN2B and GRIA1 (By similarity). Interacts with TNIK. Interacts with MINK1 (By similarity).
    SequenceCaution:
    • Sequence=AAH37329.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH37329.1; Type=Miscellaneous discrepancy; Note=The cDNA sequence appears to be not correctly spliced at its 3-end.; Evidence={ECO:0000305};

    Alternative splice isoforms for TANC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TANC1 Gene

Proteomics data for TANC1 Gene at MOPED

Post-translational modifications for TANC1 Gene

  • Phosphorylated; by MINK1 and TNIK upon stimulation by RAP2A.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TANC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TANC1 Gene

Domains for TANC1 Gene

Gene Families for TANC1 Gene

HGNC:
  • ANKRD :Ankyrin repeat domain containing
  • TTC :Tetratricopeptide (TTC) repeat domain containing

UniProtKB/Swiss-Prot:

TANC1_HUMAN
Family:
  • Belongs to the TANC family.:
    • Q9C0D5
Similarity:
  • Contains 11 ANK repeats.:
    • Q9C0D5
  • Contains 3 TPR repeats.:
    • Q9C0D5
genes like me logo Genes that share domains with TANC1: view

Function for TANC1 Gene

Molecular function for TANC1 Gene

UniProtKB/Swiss-Prot Function: May be a scaffold component in the postsynaptic density.

Gene Ontology (GO) - Molecular Function for TANC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TANC1: view

Phenotypes for TANC1 Gene

genes like me logo Genes that share phenotypes with TANC1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TANC1 Gene

Localization for TANC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TANC1 Gene

Cell junction, synapse, postsynaptic cell membrane, postsynaptic density.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TANC1 Gene COMPARTMENTS Subcellular localization image for TANC1 gene
Compartment Confidence
cytosol 3
plasma membrane 3
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for TANC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014069 postsynaptic density IEA --
GO:0030054 cell junction IEA --
GO:0030425 dendrite IEA --
GO:0043025 neuronal cell body IEA --
GO:0043679 axon terminus IEA --
genes like me logo Genes that share ontologies with TANC1: view

Pathways for TANC1 Gene

SuperPathways for TANC1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TANC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007520 myoblast fusion IEA --
GO:0008542 visual learning IEA --
GO:0097062 dendritic spine maintenance IEA --
genes like me logo Genes that share ontologies with TANC1: view

No data available for Pathways by source for TANC1 Gene

Transcripts for TANC1 Gene

Unigene Clusters for TANC1 Gene

Tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TANC1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a ·
SP1: - - - -
SP2: - - - - - - - - - - - - - - - -
SP3: -
SP4:
SP5:
SP6:

ExUns: 21b · 21c ^ 22 ^ 23
SP1: -
SP2: -
SP3:
SP4:
SP5:
SP6:

Relevant External Links for TANC1 Gene

GeneLoc Exon Structure for
TANC1
ECgene alternative splicing isoforms for
TANC1

Expression for TANC1 Gene

mRNA expression in normal human tissues for TANC1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TANC1 Gene

SOURCE GeneReport for Unigene cluster for TANC1 Gene Hs.61590

genes like me logo Genes that share expressions with TANC1: view

Orthologs for TANC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TANC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TANC1 36
  • 99.49 (n)
  • 99.07 (a)
TANC1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TANC1 36
  • 87.35 (n)
  • 89.5 (a)
TANC1 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TANC1 36
  • 90.51 (n)
  • 94.41 (a)
TANC1 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tanc1 36
  • 86.17 (n)
  • 89.76 (a)
Tanc1 16
Tanc1 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TANC1 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TANC1 37
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tanc1 36
  • 85.54 (n)
  • 88.59 (a)
chicken
(Gallus gallus)
Aves TANC1 36
  • 71.41 (n)
  • 74.31 (a)
TANC1 37
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TANC1 37
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tanc1 36
  • 66.8 (n)
  • 68.06 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100334650 36
  • 66.05 (n)
  • 67.95 (a)
TANC1 (2 of 2) 37
  • 65 (a)
OneToMany
tanc1a 37
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta rols 37
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 39 (a)
ManyToMany
-- 37
  • 34 (a)
ManyToMany
CSA.1817 37
  • 43 (a)
ManyToMany
Species with no ortholog for TANC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TANC1 Gene

ENSEMBL:
Gene Tree for TANC1 (if available)
TreeFam:
Gene Tree for TANC1 (if available)

Paralogs for TANC1 Gene

Selected SIMAP similar genes for TANC1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TANC1: view

Variants for TANC1 Gene

Sequence variations from dbSNP and Humsavar for TANC1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs169072 -- 159,023,524(-) tctct(C/T)ccaaa intron-variant
rs169073 -- 159,094,440(+) ACCTG(C/T)TTGCA intron-variant
rs171933 -- 159,113,013(-) aggtt(A/G)caatg intron-variant
rs171934 -- 159,111,491(-) CATCA(A/G)GAGAC intron-variant
rs171935 -- 159,100,008(+) TCTGT(C/T)TGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TANC1 Gene

Variant ID Type Subtype PubMed ID
dgv478n27 CNV Gain 19166990
nsv524373 CNV Loss 19592680
nsv518893 CNV Gain 19592680
nsv2993 CNV Insertion 18451855
dgv28n50 CNV Loss 21212237
esv2721030 CNV Deletion 23290073
esv1033253 CNV Deletion 17803354
esv1007408 CNV Deletion 20482838
nsv819030 CNV Gain 19587683
nsv433277 CNV Loss 18776910
esv29829 CNV Gain 19812545
dgv671n67 CNV Gain+Loss 20364138
nsv820838 CNV Deletion 20802225
nsv514100 CNV Loss 21397061
nsv821769 CNV Loss 20364138
esv270687 CNV Insertion 20981092
esv2675252 CNV Deletion 23128226
esv259824 OTHER Complex 20981092
esv33791 CNV Gain 17666407

Relevant External Links for TANC1 Gene

HapMap Linkage Disequilibrium report
TANC1
Human Gene Mutation Database (HGMD)
TANC1

Disorders for TANC1 Gene

Relevant External Links for TANC1

Genetic Association Database (GAD)
TANC1
genes like me logo Genes that share disorders with TANC1: view

No data available for UniProtKB/Swiss-Prot for TANC1 Gene

Publications for TANC1 Gene

  1. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat B.E. … Tseng Z.H. (BMC Cardiovasc Disord 2011) 3 49
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  3. A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins. (PMID: 15673434) Suzuki T. … Endo S. (Eur. J. Neurosci. 2005) 2 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for TANC1 Gene

Sources for TANC1 Gene

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