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Aliases for TAMM41 Gene

Aliases for TAMM41 Gene

  • TAM41 Mitochondrial Translocator Assembly And Maintenance Homolog 2 3 5
  • Mitochondrial Translocator Assembly And Maintenance Protein 41 Homolog 3 4
  • CDP-Diacylglycerol Synthase 3 4
  • CDP-DAG Synthase 3 4
  • C3orf31 3 4
  • TAM41 3 4
  • TAM41, Mitochondrial Translocator Assembly And Maintenance Protein, Homolog (S. Cerevisiae) 2
  • TAM41, Mitochondrial Translocator Assembly And Maintenance Protein, Homolog 3
  • Chromosome 3 Open Reading Frame 31 2
  • MMP37-Like Protein, Mitochondrial 3
  • EC 2.7.7.41 4
  • RAM41 3

External Ids for TAMM41 Gene

Previous HGNC Symbols for TAMM41 Gene

  • C3orf31

Summaries for TAMM41 Gene

GeneCards Summary for TAMM41 Gene

TAMM41 (TAM41 Mitochondrial Translocator Assembly And Maintenance Homolog) is a Protein Coding gene. GO annotations related to this gene include phosphatidate cytidylyltransferase activity.

UniProtKB/Swiss-Prot for TAMM41 Gene

  • Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAMM41 Gene

Genomics for TAMM41 Gene

Regulatory Elements for TAMM41 Gene

Enhancers for TAMM41 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TAMM41 on UCSC Golden Path with GeneCards custom track

Promoters for TAMM41 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TAMM41 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAMM41 Gene

Chromosome:
3
Start:
11,790,442 bp from pter
End:
11,846,919 bp from pter
Size:
56,478 bases
Orientation:
Minus strand

Genomic View for TAMM41 Gene

Genes around TAMM41 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAMM41 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAMM41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAMM41 Gene

Proteins for TAMM41 Gene

  • Protein details for TAMM41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BW9-TAM41_HUMAN
    Recommended name:
    Phosphatidate cytidylyltransferase, mitochondrial
    Protein Accession:
    Q96BW9
    Secondary Accessions:
    • B4DIY7
    • C9J2U4

    Protein attributes for TAMM41 Gene

    Size:
    452 amino acids
    Molecular mass:
    51067 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TAMM41 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAMM41 Gene

Proteomics data for TAMM41 Gene at MOPED

Post-translational modifications for TAMM41 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TAMM41 Gene

Domains & Families for TAMM41 Gene

Protein Domains for TAMM41 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAMM41 Gene

Graphical View of Domain Structure for InterPro Entry

Q96BW9

UniProtKB/Swiss-Prot:

TAM41_HUMAN :
  • Belongs to the TAM41 family.
Family:
  • Belongs to the TAM41 family.
genes like me logo Genes that share domains with TAMM41: view

No data available for Gene Families for TAMM41 Gene

Function for TAMM41 Gene

Molecular function for TAMM41 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
UniProtKB/Swiss-Prot Function:
Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane (By similarity).

Enzyme Numbers (IUBMB) for TAMM41 Gene

genes like me logo Genes that share phenotypes with TAMM41: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TAMM41 Gene

Localization for TAMM41 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAMM41 Gene

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAMM41 Gene COMPARTMENTS Subcellular localization image for TAMM41 gene
Compartment Confidence
mitochondrion 5
cytosol 3
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TAMM41 Gene

Pathways & Interactions for TAMM41 Gene

SuperPathways for TAMM41 Gene

No Data Available

UniProtKB/Swiss-Prot Q96BW9-TAM41_HUMAN

  • Pathway: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.

Gene Ontology (GO) - Biological Process for TAMM41 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TAMM41 Gene

Drugs & Compounds for TAMM41 Gene

No Compound Related Data Available

Transcripts for TAMM41 Gene

Unigene Clusters for TAMM41 Gene

TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAMM41 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1: - - - -
SP2: - - - - -
SP3:
SP4:
SP5:

Relevant External Links for TAMM41 Gene

GeneLoc Exon Structure for
TAMM41
ECgene alternative splicing isoforms for
TAMM41

Expression for TAMM41 Gene

mRNA expression in normal human tissues for TAMM41 Gene

Protein differential expression in normal tissues from HIPED for TAMM41 Gene

This gene is overexpressed in Breast (40.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAMM41 Gene



SOURCE GeneReport for Unigene cluster for TAMM41 Gene Hs.475472

genes like me logo Genes that share expression patterns with TAMM41: view

Protein tissue co-expression partners for TAMM41 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TAMM41 Gene

Orthologs for TAMM41 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TAMM41 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TAMM41 35
  • 87.56 (n)
  • 91.34 (a)
-- 36
  • 82 (a)
OneToMany
TAMM41 36
  • 85 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TAMM41 35
  • 91.2 (n)
  • 89.32 (a)
TAMM41 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tamm41 35
  • 81.7 (n)
  • 81.9 (a)
Tamm41 16
Tamm41 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TAMM41 35
  • 99.51 (n)
  • 99.11 (a)
TAMM41 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tamm41 35
  • 82.39 (n)
  • 81.6 (a)
oppossum
(Monodelphis domestica)
Mammalia TAMM41 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAMM41 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAMM41 35
  • 71.63 (n)
  • 70.24 (a)
TAMM41 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAMM41 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5567 35
tamm41 35
  • 66.12 (n)
  • 64.48 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13122 35
zebrafish
(Danio rerio)
Actinopterygii Dr.16518 35
tamm41 35
  • 66.27 (n)
  • 67.26 (a)
tamm41 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004242 35
  • 48.05 (n)
  • 44.48 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33331 35
  • 48.2 (n)
  • 41.4 (a)
CG33331 36
  • 35 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y71F9B.2 35
  • 46.5 (n)
  • 39.49 (a)
Y71F9B.2 36
  • 36 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAM41 36
  • 25 (a)
OneToOne
TAM41 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G47630 35
  • 48.04 (n)
  • 34.34 (a)
rice
(Oryza sativa)
Liliopsida Os11g0549690 35
  • 54.41 (n)
  • 44.12 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04429 35
  • 49.26 (n)
  • 40.45 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tam41 35
  • 49.24 (n)
  • 39.61 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToOne
Species with no ortholog for TAMM41:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAMM41 Gene

ENSEMBL:
Gene Tree for TAMM41 (if available)
TreeFam:
Gene Tree for TAMM41 (if available)

Paralogs for TAMM41 Gene

Pseudogenes.org Pseudogenes for TAMM41 Gene

genes like me logo Genes that share paralogs with TAMM41: view

No data available for Paralogs for TAMM41 Gene

Variants for TAMM41 Gene

Sequence variations from dbSNP and Humsavar for TAMM41 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs7641243 - 11,839,286(+) GAACG(C/T)TAGTG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs11551661 - 11,829,741(+) CTCTA(C/T)GAAGA nc-transcript-variant, reference, missense
rs9267 -- 11,790,479(-) GTTAT(A/G)TGTAG nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs150556 -- 11,805,134(+) aaagg(G/T)gggac intron-variant
rs167340 -- 11,824,381(+) ttttg(G/T)gacaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAMM41 Gene

Variant ID Type Subtype PubMed ID
dgv809e201 CNV Deletion 23290073
nsv436362 CNV Deletion 17901297
nsv436869 CNV Insertion 17901297
esv4117 CNV Complex 18987735
esv2677845 CNV Deletion 23128226
nsv876539 CNV Gain 21882294
nsv834616 CNV Loss 17160897
nsv821991 CNV Loss 20364138
nsv3700 CNV Loss 18451855

Variation tolerance for TAMM41 Gene

Residual Variation Intolerance Score: 34.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.01; 84.19% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TAMM41 Gene

Disorders for TAMM41 Gene

Relevant External Links for TAMM41

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAMM41

No disorders were found for TAMM41 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAMM41 Gene

Publications for TAMM41 Gene

  1. Mitochondrial membrane biogenesis: phospholipids and proteins go hand in hand. (PMID: 19237595) Gohil V.M. … Greenberg M.L. (J. Cell Biol. 2009) 2 3 67
  2. Identification of Tam41 maintaining integrity of the TIM23 protein translocator complex in mitochondria. (PMID: 16943180) Tamura Y. … Endo T. (J. Cell Biol. 2006) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample. (PMID: 21314694) Kendler K.S. … Gejman P.V. (Alcohol. Clin. Exp. Res. 2011) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for TAMM41 Gene

Sources for TAMM41 Gene

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