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TAMM41 Gene

protein-coding   GIFtS: 43
GCID: GC03M011831

TAM41, Mitochondrial Translocator Assembly And Maintenance...

(Previous name: chromosome 3 open reading frame 31)
(Previous symbol: C3orf31)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TAM41, Mitochondrial Translocator Assembly And Maintenance Protein,
Homolog (S. Cerevisiae)1 2
     RAM412 5
C3orf311 2 3 5     Chromosome 3 Open Reading Frame 311
TAM412 3     Mitochondrial Translocator Assembly And Maintenance Protein 41 Homolog2
MMP37-Like Protein, Mitochondrial2 3     

External Ids:    HGNC: 251871   Entrez Gene: 1320012   Ensembl: ENSG000001445597   OMIM: 6149485   UniProtKB: Q96BW93   

Export aliases for TAMM41 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TAMM41 Gene:
TAMM41 (TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae)) is a protein-coding gene. Diseases associated with TAMM41 include alcohol dependence, and schizophrenia.

UniProtKB/Swiss-Prot: TAM41_HUMAN, Q96BW9
Function: May be involved in the translocation of transit peptide-containing proteins across the mitochondrial
inner membrane (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TAMM41
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TAMM41

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAMM41


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.2   Ensembl cytogenetic band:  3p25.2   HGNC cytogenetic band: 3p25.2

TAMM41 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAMM41 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M011831:  view genomic region     (about GC identifiers)

Start:
11,831,916 bp from pter      End:
11,888,393 bp from pter
Size:
56,478 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TAM41_HUMAN, Q96BW9 (See protein sequence)
Recommended Name: Mitochondrial translocator assembly and maintenance protein 41 homolog precursor  
Size: 452 amino acids; 51067 Da
Secondary accessions: B4DIY7
Alternative splicing: 2 isoforms:  Q96BW9-1   Q96BW9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TAMM41: NX_Q96BW9

Explore proteomics data for TAMM41 at MOPED


See TAMM41 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001271330.1  NP_620162.1  

ENSEMBL proteins: 
 ENSP00000398596   ENSP00000273037   ENSP00000406054   ENSP00000399218   ENSP00000388598  
 ENSP00000392289   ENSP00000390910  

TAMM41 Human Recombinant Protein Products:

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Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR015222 Mmp37

Graphical View of Domain Structure for InterPro Entry Q96BW9

ProtoNet protein and cluster: Q96BW9

UniProtKB/Swiss-Prot: TAM41_HUMAN, Q96BW9
Similarity: Belongs to the MMP37/TAM41 family


TAMM41 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: TAM41_HUMAN, Q96BW9
Function: May be involved in the translocation of transit peptide-containing proteins across the mitochondrial
inner membrane (By similarity)

Phenotypes:
     2 GenomeRNAi human phenotypes for TAMM41:

 Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TAMM41
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miRNA
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Cell Line
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In Situ Assay
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TAM41_HUMAN, Q96BW9: Mitochondrion (By similarity)

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion ----
GO:0031314extrinsic component of mitochondrial inner membrane ISS--

TAMM41 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TAMM41
Interactions:

    Search GeneGlobe Interaction Network for TAMM41

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

Selected Interacting proteins for TAMM41 (Q96BW93 ENSP000002730374) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
InteractantInteraction Details
GeneCardExternal ID(s)
PGS1Q32NB83, ENSP000002627644I2D: score=1 STRING: ENSP00000262764
HSPD1P108093I2D: score=2 
RFC4P352493I2D: score=2 
VPS45Q9NRW73I2D: score=2 
CCNCP248633I2D: score=1 
About this table

Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0030150protein import into mitochondrial matrix ISS--

TAMM41 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TAMM41 (TAM41)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for TAMM41 gene (2 alternative transcripts): 
NM_001284401.1  NM_138807.3  

Unigene Cluster for TAMM41:

TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae)
Hs.475472  [show with all ESTs]
Unigene Representative Sequence: AK024271
11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000498127 ENST00000455809 ENST00000273037(uc003bwh.3) ENST00000457498(uc003bwi.3)
ENST00000486090 ENST00000414736 ENST00000444133(uc011auo.1) ENST00000460246
ENST00000411947(uc011aup.1) ENST00000417723(uc010hdy.1) ENST00000494388

miRNA
Products:
     
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Search for qRT-PCR Assays for microRNAs that regulate TAMM41
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Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat TAMM41
Clone
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Primer
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OriGene qPCR primer pairs and template standards for TAMM41
OriGene qSTAR qPCR primer pairs in human, mouse for TAMM41
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  QuantiFast Probe-based Assays in human, mouse, rat TAMM41

Additional mRNA sequence: 

AK024271.1 AK092776.1 AK093703.1 AK295839.1 AK303598.1 AK309733.1 AK310993.1 BC015088.2 

13 DOTS entries:

DT.100035699  DT.100815519  DT.114414  DT.114415  DT.91760407  DT.95157642  DT.100815514  DT.95165326 
DT.120839964  DT.120839987  DT.91659600  DT.91852295  DT.101969127 

Selected AceView cDNA sequences (see all 93):

AI911221 NM_138807 AA234815 CB160665 CB163184 BC015088 BP374397 BX470689 
BU188329 CR615506 BP378979 BI962958 CA431122 CK903595 BU948053 F07997 
CB128541 AA831785 Z41071 AA235277 AL136788 BF513369 AL561480 AX747723 

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for TAMM41    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b
SP1:                    -                 -                       -     -                           
SP2:                    -                 -                       -     -           -               
SP3:                                                                                                
SP4:                                                                                                
SP5:                                                                                                


ECgene alternative splicing isoforms for TAMM41

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TAMM41 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: ATCCCGACTG
TAMM41 Expression
About this image

TAMM41 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TAMM41 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.475472
    Custom PCR Arrays for TAMM41
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QuantiFast Probe-based Assays in human, mouse, rat TAMM41
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAMM41

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for TAMM41 gene from Selected species (see all 21)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tamm411 , 5 RIKEN cDNA 1500001M20 gene5
TAM41, mitochondrial translocator assembly and maintenance more1
81.7(n)1
81.9(a)1
  6 (53.14 cM)5
689711  NM_026894.11  NP_081170.11 
 1150043815 
chicken
(Gallus gallus)
Aves TAMM411 TAM41, mitochondrial translocator assembly and maintenance more 71.63(n)
70.24(a)
  427581  XM_425154.4  XP_425154.2 
lizard
(Anolis carolinensis)
Reptilia TAMM416
TAM41, mitochondrial translocator assembly and mai...
65(a)
1 ↔ 1
2(158245000-158273402)
African clawed frog
(Xenopus laevis)
Amphibia Xl.131222 Xenopus laevis transcribed sequence with weak similarity more 76.46(n)    CF519795.1 
zebrafish
(Danio rerio)
Actinopterygii Dr.165182 Transcribed sequences 76.05(n)    BI708361.1 
fruit fly
(Drosophila melanogaster)
Insecta CG333311 CG33331 48.2(n)
41.4(a)
  2768668  NM_206491.2  NP_996213.1 
worm
(Caenorhabditis elegans)
Secernentea Y71F9B.21 Y71F9B.2 46.5(n)
39.49(a)
  171836  NM_058633.1  NP_491034.1 
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAM41(YGR046W)4 Mitochondrial protein involved in protein import into more   --   7(584895-586052) 852937  NP_011560.1 
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G476301 AT3G47630 48.04(n)
34.34(a)
  823917  NM_001035750.1  NP_001030827.1 
rice
(Oryza sativa)
Liliopsida Os11g05496901 Os11g0549690 54.41(n)
44.12(a)
  9267407  NM_001189670.1  NP_001176599.1 


ENSEMBL Gene Tree for TAMM41 (if available)
TreeFam Gene Tree for TAMM41 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TAMM41 gene

TAMM41 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for TAMM41
PGOHUM00000248343


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TAMM41 (see all 1326)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs98832921,2
C,F,A,H--11831580(+) AAAAAA/CCAAGT 1 -- int115Minor allele frequency- C:0.11NA NS EA CSA WA 1439
rs738130501,2
C,F--11831593(+) ACAGGT/ATGGAG 1 -- int11Minor allele frequency- A:0.50WA 2
rs1868185111,2
--11831603(+) GACTAC/GAGACA 1 -- int10--------
rs22918251,2
C,F,O,A,H--11831670(+) GTGTTC/GACAGC 1 -- int129Minor allele frequency- G:0.34NS EA NA WA CSA 1477
rs1920089711,2
--11831689(+) AATTTG/TTCATG 1 -- int10--------
rs1839379911,2
--11831849(+) TTTAAA/GAAACC 1 -- int10--------
rs1878058821,2
--11831920(+) GTTCTA/GTCAAA 1 -- ut310--------
rs92671,2
C,F,H--11831953(-) GTTATG/ATGTAG 1 -- ut31 ese311Minor allele frequency- A:0.33MN NA WA EA EU 1151
rs1381073831,2
C--11832087(+) GAAGAC/TGGAGG 1 -- int10--------
rs1899825151,2
C--11832091(+) ATGGAA/GGCTTG 1 -- int10--------

HapMap Linkage Disequilibrium report for TAMM41 (11831916 - 11888393 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for TAMM41:    About this table    
Variant IDTypeSubtypePubMed ID
nsv436362CNV Deletion17901297
esv2677845CNV Deletion23128226
dgv809e201CNV Deletion23290073
nsv436869CNV Insertion17901297
nsv821991CNV Loss20364138
nsv3700CNV Loss18451855
nsv834616CNV Loss17160897
nsv876539CNV Gain21882294
esv4117CNV Complex18987735

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing TAMM41
DNA2.0 Custom Variant and Variant Library Synthesis for TAMM41

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 614948    OMIM disorders: --

3 diseases for TAMM41:    
About MalaCards
alcohol dependence    schizophrenia    malaria


TAMM41 for disorders           About GeneDecksing


Export disorders for TAMM41 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TAMM41 gene, integrated from 10 sources (see all 11):
(articles sorted by number of sources associating them with TAMM41)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Mitochondrial membrane biogenesis: phospholipids and proteins go hand in hand. (PubMed id 19237595)1, 3 Gohil V.M. and Greenberg M.L. (J. Cell Biol. 2009)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
  5. Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample. (PubMed id 21314694)1 Kendler K.S....Gejman P.V. (Alcohol. Clin. Exp. Res. 2011)
  6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
  7. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
  8. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  10. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1 Wiemann S.... Poustka A. (Genome Res. 2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 132001 HGNC: 25187 AceView: MGC16471 Ensembl:ENSG00000144559 euGenes: HUgn132001
ECgene: TAMM41 H-InvDB: TAMM41

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TAMM41 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TAMM41 gene:
Search GeneIP for patents involving TAMM41

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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