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TALDO1 Gene

protein-coding   GIFtS: 69
GCID: GC11P000749

Transaldolase 1

  See TALDO1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transaldolase 11 2     TALH2
TAL2 3     Dihydroxyacetone Transferase2
TALDOR2 3     Glycerone Transferase2
EC 2.2.1.23 8     transaldolase2
TAL-H2     TALDO3

External Ids:    HGNC: 115591   Entrez Gene: 68882   Ensembl: ENSG000001771567   OMIM: 6020635   UniProtKB: P378373   

Export aliases for TALDO1 gene to outside databases

Previous GC identifers: GC11U990129 GC11M000780 GC11M000433 GC11P000738 GC11P000737 GC11P000564


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TALDO1 Gene:
Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for
nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced
state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of
transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are
conflicting map locations. The second and third exon of this gene were developed by insertion of a
retrotransposable element. This gene is thought to be involved in multiple sclerosis. (provided by RefSeq, Jul
2008)

GeneCards Summary for TALDO1 Gene:
TALDO1 (transaldolase 1) is a protein-coding gene. Diseases associated with TALDO1 include transaldolase deficiency, and hereditary fructose intolerance syndrome. GO annotations related to this gene include sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity.

UniProtKB/Swiss-Prot: TALDO_HUMAN, P37837
Function: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the TALDO1 gene promoter:
         Pax-5   POU3F1   CUTL1   HNF-3beta   YY1   AREB6   SRY   FOXO4   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTALDO1 promoter sequence
   Search Chromatin IP Primers for TALDO1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TALDO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5-p15.4   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5-p15.4

TALDO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TALDO1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P000749:  view genomic region     (about GC identifiers)

Start:
747,329 bp from pter      End:
765,024 bp from pter
Size:
17,696 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TALDO_HUMAN, P37837 (See protein sequence)
Recommended Name: Transaldolase  
Size: 337 amino acids; 37540 Da
Subunit: Homodimer
1 PDB 3D structure from and Proteopedia for TALDO1:
1F05 (3D)    
Secondary accessions: B2R8M2 O00751 Q8WV32 Q8WZ45

Explore the universe of human proteins at neXtProt for TALDO1: NX_P37837

Explore proteomics data for TALDO1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys115, Lys130, Lys219, Lys230, Lys269, Lys277, Lys307, Lys321
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TALDO1 (P37837) (see all 21)
     SPFVGRI  DARLSFD  DEKSFRW  TTNPSLI 


    See TALDO1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006746.1  
    ENSEMBL proteins: 
     ENSP00000321259   ENSP00000435042   ENSP00000437098   ENSP00000433501  
    Reactome Protein details: P37837

    TALDO1 Human Recombinant Protein Products:

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    antibodies-online proteins for TALDO1 (48 products) 

     
    antibodies-online peptides for TALDO1

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    antibodies-online kits for TALDO1 (11 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR013785 Aldolase_TIM
     IPR018225 Transaldolase_AS
     IPR001585 Transaldolase
     IPR004730 Transaldolase_1

    Graphical View of Domain Structure for InterPro Entry P37837

    ProtoNet protein and cluster: P37837

    1 Blocks protein domain: IPB001585 Transaldolase

    UniProtKB/Swiss-Prot: TALDO_HUMAN, P37837
    Similarity: Belongs to the transaldolase family. Type 1 subfamily


    Find genes that share domains with TALDO1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TALDO_HUMAN, P37837
    Function: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
    Catalytic activity: Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate +
    D-fructose 6-phosphate

         Genatlas biochemistry entry for TALDO1:
    transaldolase 1,key enzyme of the pentose phosphate pathway,expressed in the oligodendrocyte

         Enzyme Number (IUBMB): EC 2.2.1.21 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004801sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity IEA--
    GO:0030246carbohydrate binding ----
    GO:0048029monosaccharide binding IEA--
         
    Find genes that share ontologies with TALDO1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TALDO1:
     Decreased POU5F1-GFP protein e 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Taldo1):
     homeostasis/metabolism  reproductive system 

    Find genes that share phenotypes with TALDO1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Taldo1tm1Perl for TALDO1

       genOway: Develop your customized and physiologically relevant rodent model for TALDO1

    miRNA
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    miRTarBase miRNAs that target TALDO1:
    hsa-mir-378a-5p (MIRT043964), hsa-mir-92a-3p (MIRT048990), hsa-mir-935 (MIRT036671)

    Block miRNA regulation of human, mouse, rat TALDO1 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate TALDO1
    SwitchGear 3'UTR luciferase reporter plasmidTALDO1 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: TALDO1 (NM_006755)
    Sino Biological Human cDNA Clone for TALDO1
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TALDO_HUMAN, P37837: Cytoplasm (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    mitochondrion2
    extracellular1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS16130169
    GO:0005829cytosol TAS--
    GO:0043231intracellular membrane-bounded organelle IEA--
    GO:0070062extracellular vesicular exosome IDA--

    Find genes that share ontologies with TALDO1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TALDO1 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Pentose Phosphate Pathway (WikiPathways)
    Pentose Phosphate Pathway
    Insulin effects increased synthesis of Xylulose-5-Phosphate0.00
    Pentose phosphate pathway (hexose monophosphate shunt)0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Carbon metabolism
    Carbon metabolism0.38
    Biosynthesis of amino acids0.38
    4Integration of energy metabolism
    Integration of energy metabolism0.75
    5MPS VI - Maroteaux-Lamy syndrome
    Metabolism of carbohydrates0.45


    Find genes that share SuperPaths with TALDO1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TALDO1
        Pentose Phosphate Pathway


    2 Reactome Pathways for TALDO1
        Pentose phosphate pathway (hexose monophosphate shunt)
    Insulin effects increased synthesis of Xylulose-5-Phosphate


    4 Kegg Pathways  (Kegg details for TALDO1):
        Pentose phosphate pathway
    Metabolic pathways
    Carbon metabolism
    Biosynthesis of amino acids

    UniProtKB/Swiss-Prot: TALDO_HUMAN, P37837
    Pathway: Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose
    6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3

        Pathway & Disease-focused RT2 Profiler PCR Array including TALDO1: 

              Glucose Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TALDO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TALDO1 (P378372, 3 ENSP000003212594) via UniProtKB, MINT, STRING, and/or I2D (see all 113)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZHX1Q9UKY12, 3, ENSP000002978574MINT-3980591 I2D: score=3 STRING: ENSP00000297857
    CHD3Q128732, 3, ENSP000003697164MINT-3980574 I2D: score=3 STRING: ENSP00000369716
    LSM8O957773, ENSP000002492994I2D: score=4 STRING: ENSP00000249299
    G6PDP114133, ENSP000003771924I2D: score=1 STRING: ENSP00000377192
    EIF6P565373, ENSP000003635594I2D: score=1 STRING: ENSP00000363559
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0005999xylulose biosynthetic process TAS--
    GO:0006002fructose 6-phosphate metabolic process IEA--
    GO:0006098pentose-phosphate shunt TAS--
    GO:0006112energy reserve metabolic process TAS--

    Find genes that share ontologies with TALDO1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TALDO1 (TALDO)

    6 HMDB Compounds for TALDO1    About this table
    CompoundSynonyms CAS #PubMed Ids
    D-Erythrose 4-phosphateD-Erythrose 4-phosphate (see all 11)585-18-2--
    D-Glyceraldehyde 3-phosphate2-hydroxy-3-(phosphonooxy)-Propanal (see all 11)142-10-9--
    D-Sedoheptulose 7-phosphate7-(dihydrogen phosphate) sedoheptulose (see all 9)2646-35-7--
    Fructose 6-phosphateD-Fructose 6-phosphate (see all 13)643-13-0--
    SedoheptuloseD-Altro-2-heptulose (see all 4)3019-74-7--
    ZolpidemAmbien (see all 7)82626-48-0--

    Selected Novoseek inferred chemical compound relationships for TALDO1 gene (see all 29)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sedoheptulose 7-phosphate 93.5 6 15115436 (1), 17603756 (1), 8333192 (1), 16055050 (1)
    ribose 5-phosphate 88.4 8 16435188 (1), 11283793 (1), 12459274 (1), 18987987 (1) (see all 7)
    erythritol 76.8 2 17095351 (1), 15877206 (1)
    6-phosphogluconate 74.4 6 8955144 (2), 2111278 (2), 12215204 (1), 10877828 (1)
    glucose 6-phosphate 71.9 17 8955144 (2), 18183605 (2), 2111278 (2), 9612242 (1) (see all 10)
    fructose-6-phosphate 70.2 6 18687684 (1), 19780152 (1), 8357848 (1), 19401148 (1) (see all 6)
    xylitol 68.9 6 17095351 (1), 12555554 (1), 15877206 (1)
    glyceraldehyde 3-phosphate 67.2 7 18183605 (2), 15840824 (1), 17119969 (1), 17934142 (1) (see all 6)
    fructose-1,6-bisphosphate 60.6 2 16834328 (1)
    sugar phosphate 59.8 1 18183605 (1)



    Find genes that share compounds with TALDO1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TALDO1 gene: 
    NM_006755.1  

    Unigene Cluster for TALDO1:

    Transaldolase 1
    Hs.438678  [show with all ESTs]
    Unigene Representative Sequence: BM804717
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319006(uc001lqz.3 uc001lra.3) ENST00000528070 ENST00000532685
    ENST00000528097 ENST00000530440 ENST00000530119(uc010qwl.2) ENST00000533796
    ENST00000530666 ENST00000532202
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      QuantiTect SYBR Green Assays in human, mouse, rat TALDO1
      QuantiFast Probe-based Assays in human, mouse, rat TALDO1

    Additional mRNA sequence: 

    AK295537.1 AK313427.1 BC009680.2 BC010103.2 BC018847.2 L19437.2 

    Selected DOTS entries (see all 26):

    DT.454449  DT.99986732  DT.100678861  DT.100848180  DT.100659500  DT.100678863  DT.91816899  DT.100844032 
    DT.87079267  DT.92452561  DT.95376123  DT.120695048  DT.91915246  DT.95376116  DT.95376124  DT.100678867 
    DT.100871008  DT.120695036  DT.95376121  DT.95376142  DT.97860567  DT.97860568  DT.100757892  DT.92452565 

    Selected AceView cDNA sequences (see all 827):

    BQ286425 CB108888 BG748022 BQ005950 BF797380 BM972208 CA748713 BU624787 
    AA486792 BM977733 BG167081 CB851631 BM918982 BQ057940 BQ054886 BM846888 
    AA315286 BU158733 CA413122 BU190694 BQ226080 CB125136 CB141628 BM831101 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TALDO1 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9
    SP1:              -           -                       -                                   -         
    SP2:              -           -                       -                                   -         
    SP3:              -           -     -                 -                                             
    SP4:                          -     -                                                               
    SP5:              -           -                                                                     


    ECgene alternative splicing isoforms for TALDO1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    TALDO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCGCCTCCT
    TALDO1 Expression
    About this image


    TALDO1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Kidney (Urinary System)
             Metanephros
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
    TALDO1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TALDO1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.438678
        Pathway & Disease-focused RT2 Profiler PCR Array including TALDO1: 
              Glucose Metabolism in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat TALDO1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TALDO1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TALDO1 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Taldo11 , 5 transaldolase 11, 5 88.13(n)1
    94.36(a)1
      7 (86.73 cM)5
    213511  NM_011528.41  NP_035658.11 
     1413921995 
    chicken
    (Gallus gallus)
    Aves TALDO11 transaldolase 1 77.45(n)
    83.98(a)
      423019  NM_001031177.1  NP_001026348.1 
    lizard
    (Anolis carolinensis)
    Reptilia TALDO16
    transaldolase 1
    83(a)
    1 ↔ 1
    1(73956107-73967590)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.252122 Xenopus laevis transcribed sequence with moderate similarity more 79.06(n)    BX843089.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc32g022 wufc32g02 79.13(n)   324556  BC061957.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Transaldolase3
    Tal1
    pentose-phosphate shunt, non-oxidative
    branch more3
    Tal1
    66(a)3
    64.61(n)1
    65.74(a)1
      60A123
    378041  NM_079111.21  NP_523835.21 
    worm
    (Caenorhabditis elegans)
    Secernentea Y24D9A.8b3
    Y24D9A.81
    Y24D9A.81 61(a)
    (best of 2)3
    61.53(n)1
    61.64(a)1
      IV(4388414-4388963)3
    1772021  NM_171314.61  NP_741369.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NQM1(YGR043C)4
    TAL11
    Transaldolase of unknown function; transcription is more4
    TAL11
    57.04(n)1
    59.88(a)1
      7(581436-580435)4
    8510681  NP_013458.11  8529344 
     NP_011557.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G122301 AT1G12230 46.75(n)
    35.06(a)
      837776  NM_101095.3  NP_563900.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g01543001 Os08g0154300 47.98(n)
    36.69(a)
      4344683  NM_001067549.1  NP_001061014.1 


    ENSEMBL Gene Tree for TALDO1 (if available)
    TreeFam Gene Tree for TALDO1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TALDO1 gene
    2 SIMAP similar genes for TALDO1 using alignment to 5 protein entries:     TALDO_HUMAN (see all proteins):
    NAA25    RBM4

    Find genes that share paralogs with TALDO1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TALDO1
    PGOHUM00000244729


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for TALDO1 (see all 487)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1906344321,2
    --682055(+) CACATA/GCTGAG 1 -- us2k10--------
    rs1829393701,2
    --682149(+) TGTTTA/CTAACC 1 -- us2k10--------
    rs1861549651,2
    --682201(+) GTCTTA/GGGAAG 1 -- us2k10--------
    rs1141161841,2
    C,F--682252(+) CTAGAC/ATGTTC 1 -- us2k11Minor allele frequency- A:0.08WA 118
    rs1465089151,2
    --682280(+) GGCCAC/TCAGCC 1 -- us2k10--------
    rs1919829321,2
    --682328(+) TATCAA/GCCATT 1 -- us2k10--------
    rs1826528231,2
    --682350(+) CATAAA/GATAAG 1 -- us2k10--------
    rs1152756011,2
    C,F--682377(+) AGATAT/ACAACA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1410358521,2
    --682445(+) GCCCAC/GGTTAG 1 -- us2k10--------
    rs1877527361,2
    --682470(+) ATCTCA/GGCTCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TALDO1 (747329 - 765024 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TALDO1 (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv182e199CNV Deletion23128226
    esv2661152CNV Deletion23128226
    dgv946n71CNV Loss21882294
    dgv944n71CNV Loss21882294
    nsv469923CNV Loss18288195
    dgv921n71CNV Loss21882294
    dgv936n71CNV Loss21882294
    dgv945n71CNV Loss21882294
    nsv896587CNV Loss21882294
    nsv522733CNV Loss19592680

    Human Gene Mutation Database (HGMD): TALDO1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TALDO1
    DNA2.0 Custom Variant and Variant Library Synthesis for TALDO1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602063   
    OMIM disorders: 606003  
    UniProtKB/Swiss-Prot: TALDO_HUMAN, P37837
  • Transaldolase 1 deficiency (TALDO1 deficiency) [MIM:606003]: Results in telangiectases of the skin,
    hepatosplenomegaly, and enlarged clitoris. Note=The disease is caused by mutations affecting the gene represented
    in this entry

  • 5 diseases for TALDO1:    
    About MalaCards
    transaldolase deficiency    hereditary fructose intolerance syndrome    multiple sclerosis    serine deficiency
    bartter disease

    3 diseases from the University of Copenhagen DISEASES database for TALDO1:
    Hereditary fructose intolerance syndrome     Bartter disease     Serine deficiency

    Find genes that share disorders with TALDO1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for TALDO1 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    transaldolase deficiency 98.6 19 17603756 (3), 15877206 (2), 15115436 (1), 16435188 (1) (see all 15)
    multiple sclerosis 42.2 17 10491006 (4), 15286385 (3), 9077532 (2), 16339578 (1) (see all 8)
    autoimmunity 40.8 4 15286385 (2), 9077532 (1), 10491006 (1)
    mimicry 38 2 10491006 (1), 7964452 (1)
    demyelination 35.9 6 20194725 (1)
    liver cirrhosis 34.4 7 15115436 (2), 11283793 (1), 14988808 (1), 17613166 (1)
    liver failure 33.2 7 19436114 (2), 15877206 (2), 17095351 (1), 15248099 (1)
    metabolic disorder 21 2 17095351 (1)
    neurological disorders 0 1 7964452 (1)
    necrosis 0 2 8955144 (1), 10765922 (1)

    Genetic Association Database (GAD): TALDO1
    Human Genome Epidemiology (HuGE) Navigator: TALDO1 (1 document)

    Export disorders for TALDO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TALDO1 gene, integrated from 10 sources (see all 116):
    (articles sorted by number of sources associating them with TALDO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human transaldolase gene (TALDO1) is located on chromosome 11 at p15.4-p15.5. (PubMed id 9339383)1, 2, 3, 9 Banki K.... Perl A. (Genomics 1997)
    2. Cloning and chromosomal localization of a paralog and a mouse homolog of the human transaldolase gene. (PubMed id 9524206)1, 2, 9 Kusuda J....Hashimoto K. (Gene 1998)
    3. Genetic variation in Transaldolase 1 and risk of squamous cell carcinoma of the head and neck. (PubMed id 18805652)1, 4, 9 Basta P.V....Olshan A.F. (Cancer Detect. Prev. 2008)
    4. Cloning and expression of the human gene for transaldolase. A novel highly repetitive element constitutes an integral part of the coding sequence. (PubMed id 8300619)1, 2, 9 Banki K.... Perl A. (J. Biol. Chem. 1994)
    5. Transaldolase deficiency: liver cirrhosis associated with a new inborn error in the pentose phosphate pathway. (PubMed id 11283793)1, 2, 9 Verhoeven N.M.... Jakobs C. (Am. J. Hum. Genet. 2001)
    6. The three-dimensional structure of human transaldolase. (PubMed id 10869557)1, 2, 9 Thorell S.... Schneider G. (FEBS Lett. 2000)
    7. Human transaldolase-associated repetitive elements are transcribed by RNA polymerase III. (PubMed id 10702296)1, 2, 9 Perl A.... Banki K. (J. Biol. Chem. 2000)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Oligodendrocyte-specific expression and autoantigenicity of transaldolase in multiple sclerosis. (PubMed id 7964452)1, 9 Banki K....Perl A. (J. Exp. Med. 1994)
    10. Cleavage of transaldolase by granzyme B causes the loss of enzymatic activity with retention of antigenicity for multiple sclerosis patients. (PubMed id 20194725)1, 9 Niland B....Perl A. (J. Immunol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6888 HGNC: 11559 AceView: TALDO1 Ensembl:ENSG00000177156 euGenes: HUgn6888
    ECgene: TALDO1 Kegg: 6888 H-InvDB: TALDO1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TALDO1 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=TALDO1[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TALDO1 gene:
    Search GeneIP for patents involving TALDO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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