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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TALDO1 Gene

protein-coding   GIFtS: 66
GCID: GC11P000737

transaldolase 1

 Explore 20 diseases affiliated with
TALDO1 via our new
 Human Malady Compendium 
Biological research products
for TALDO1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Transaldolase 11 2     TALH2
TAL2 3     Dihydroxyacetone Transferase2
TALDOR2 3     Glycerone Transferase2
EC 2.2.1.23 8     Transaldolase1
TAL-H2     TALDO3

External Ids:    HGNC: 115591   Entrez Gene: 68882   Ensembl: ENSG000001771567   OMIM: 6020635   UniProtKB: P378373   

Export aliases for TALDO1 gene to outside databases

Previous GC identifers: GC11U990129 GC11M000780 GC11M000433 GC11P000738 GC11P000564


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TALDO1:
Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic
acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and
thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is
located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The
second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to
be involved in multiple sclerosis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TALDO_HUMAN, P37837
Function: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TALDO1 gene promoter:
         Pax-5   POU3F1   CUTL1   HNF-3beta   YY1   AREB6   SRY   FOXO4   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTALDO1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TALDO1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TALDO1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5-p15.4   Ensembl cytogenetic band:  11p15.5   HGNC cytogenetic band: 11p15.5-p15.4

TALDO1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TALDO1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P000737:  view genomic region     (about GC identifiers)

Start:
747,329 bp from pter      End:
765,024 bp from pter
Size:
17,696 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TALDO_HUMAN, P37837 (See protein sequence)
Recommended Name: Transaldolase  
Size: 337 amino acids; 37540 Da
Subunit: Homodimer
Subcellular location: Cytoplasm (Probable)
1 PDB 3D structure from and Proteopedia for TALDO1:
1F05 (3D)    
Secondary accessions: B2R8M2 O00751 Q8WV32 Q8WZ45

Explore the universe of human proteins at neXtProt for TALDO1: NX_P37837

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P37837

  • 4/21 DME Specific Peptides for TALDO1 (P37837) (see all 21)
     SPFVGRI  DARLSFD  DEKSFRW  TTNPSLI 

    TALDO1 Protein expression data from MOPED and PaxDb:    About this image 
    TALDO1 Protein Expression
    REFSEQ proteins: NP_006746.1  
    ENSEMBL proteins: 
     ENSP00000321259   ENSP00000435042   ENSP00000437098   ENSP00000433501  
    Reactome Protein details: P37837
    Human Recombinant Protein Products for TALDO1: 
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    Uscn Proteins for TALDO1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005737cytoplasm TAS16130169
    GO:0005792microsome ----
    GO:0005829cytosol TAS--

    TALDO1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TALDO1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR013785 Aldolase_TIM
     IPR018225 Transaldolase_AS
     IPR001585 Transaldolase
     IPR004730 Transaldolase_1

    Graphical View of Domain Structure for InterPro Entry P37837

    ProtoNet protein and cluster: P37837

    1 Blocks protein family: IPB001585 Transaldolase

    UniProtKB/Swiss-Prot: TALDO_HUMAN, P37837
    Similarity: Belongs to the transaldolase family. Type 1 subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TALDO_HUMAN, P37837
    Function: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
    Catalytic activity: Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose
    6-phosphate

         Genatlas biochemistry entry for TALDO1:
    transaldolase 1,key enzyme of the pentose phosphate pathway,expressed in the oligodendrocyte

         Enzyme Number (IUBMB): EC 2.2.1.21 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004801sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity IEA--
    GO:0048029monosaccharide binding ----
         
    TALDO1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TALDO1:
     Decreased POU5F1-GFP protein e 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Taldo1):
     homeostasis/metabolism  reproductive system 

    TALDO1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-out Taldo1tm1Perl for TALDO1
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TALDO1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TALDO1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Metabolism
    Metabolism1.00
    Metabolic pathways0.38
    2Pentose phosphate pathway (hexose monophosphate shunt)
    Pentose phosphate pathway (hexose monophosphate shunt)1.00
    Pentose Phosphate Pathway0.88
    3Insulin effects increased synthesis of Xylulose-5-Phosphate
    Insulin effects increased synthesis of Xylulose-5-Phosphate1.00
    4Pentose phosphate pathway
    Pentose phosphate pathway1.00
    5Regulation of Insulin Secretion
    Integration of energy metabolism0.74

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for TALDO1 
        Pentose Phosphate Pathway

    5        Reactome Pathways for TALDO1
        Metabolism of carbohydrates
    Pentose phosphate pathway (hexose monophosphate shunt)
    Metabolism
    Integration of energy metabolism
    Insulin effects increased synthesis of Xylulose-5-Phosphate


    2         Kegg Pathways  (Kegg details for TALDO1):
        Pentose phosphate pathway
    Metabolic pathways

    UniProtKB/Swiss-Prot: TALDO_HUMAN, P37837
    Pathway: Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose
    6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3


    TALDO1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TALDO1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/79 Interacting proteins for TALDO1 (P378371, 2, 3 ENSP000003212594) via UniProtKB, MINT, STRING, and/or I2D (see all 79)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZHX1Q9UKY12, 3, ENSP000002978574MINT-3980591 I2D: score=3 STRING: ENSP00000297857
    NAA38O957771, 3, ENSP000002492994EBI-1056712,EBI-347779 I2D: score=4 STRING: ENSP00000249299
    CHD3Q128732, 3, ENSP000003697164MINT-3980574 I2D: score=3 STRING: ENSP00000369716
    TKTP294013, ENSP000004054554I2D: score=1 STRING: ENSP00000405455
    G6PDP114133, ENSP000003771924I2D: score=1 STRING: ENSP00000377192
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0005999xylulose biosynthetic process TAS--
    GO:0006002fructose 6-phosphate metabolic process ----
    GO:0006098pentose-phosphate shunt TAS--
    GO:0006112energy reserve metabolic process TAS--

    TALDO1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TALDO1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for TALDO1

    6 HMDB Compounds for TALDO1    About this table
    CompoundSynonyms CAS #PubMed Ids
    D-Erythrose 4-phosphateD-Erythrose 4-phosphate (see all 11)585-18-2--
    D-Glyceraldehyde 3-phosphate2-hydroxy-3-(phosphonooxy)-Propanal (see all 11)142-10-9--
    D-Sedoheptulose 7-phosphate7-(dihydrogen phosphate) sedoheptulose (see all 9)2646-35-7--
    Fructose 6-phosphateD-Fructose 6-phosphate (see all 13)643-13-0--
    SedoheptuloseD-Altro-2-heptulose (see all 4)3019-74-7--
    ZolpidemAmbien (see all 7)82626-48-0--
    10/29 Novoseek chemical compound relationships for TALDO1 gene (see all 29)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sedoheptulose 7-phosphate 93.5 6 15115436 (1), 17603756 (1), 8333192 (1), 16055050 (1)
    ribose 5-phosphate 88.4 8 16435188 (1), 11283793 (1), 12459274 (1), 18987987 (1) (see all 7)
    erythritol 76.8 2 17095351 (1), 15877206 (1)
    6-phosphogluconate 74.4 6 8955144 (2), 2111278 (2), 12215204 (1), 10877828 (1)
    glucose 6-phosphate 71.9 17 8955144 (2), 18183605 (2), 2111278 (2), 9612242 (1) (see all 10)
    fructose-6-phosphate 70.2 6 18687684 (1), 19780152 (1), 8357848 (1), 19401148 (1) (see all 6)
    xylitol 68.9 6 17095351 (1), 12555554 (1), 15877206 (1)
    glyceraldehyde 3-phosphate 67.2 7 18183605 (2), 15840824 (1), 17119969 (1), 17934142 (1) (see all 6)
    fructose-1,6-bisphosphate 60.6 2 16834328 (1)
    sugar phosphate 59.8 1 18183605 (1)

    Search CenterWatch for drugs/clinical trials and news about TALDO1 / TALDO 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for TALDO1 gene: 
    NM_006755.1  

    Unigene Cluster for TALDO1:

    Transaldolase 1
    Hs.438678  [show with all ESTs]
    Unigene Representative Sequence: BM804717
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000319006(uc001lqz.3 uc001lra.3) ENST00000528070 ENST00000532685
    ENST00000528097 ENST00000530440 ENST00000530119(uc010qwl.2) ENST00000533796
    ENST00000530666 ENST00000532202

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    Additional cDNA sequence: 

    AK295537.1 AK313427.1 BC009680.2 BC010103.2 BC018847.2 L19437.2 

    24/26 DOTS entries (see all 26):

    DT.454449  DT.99986732  DT.100678861  DT.100848180  DT.100659500  DT.100678863  DT.91816899  DT.100844032 
    DT.87079267  DT.92452561  DT.95376123  DT.120695048  DT.91915246  DT.95376116  DT.95376124  DT.100678867 
    DT.100871008  DT.120695036  DT.95376121  DT.95376142  DT.97860567  DT.97860568  DT.100757892  DT.92452565 

    24/827 AceView cDNA sequences (see all 827):

    CB143065 BQ226080 BU624787 F33409 BQ675412 AI038554 BQ026736 BI824002 
    BM670844 BP352945 CB113127 BU662836 BM842389 BF797380 BQ685791 BU626424 
    BG289711 BM840504 CB108204 CB108888 BM737969 BQ647989 BP337943 AW406218 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TALDO1 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9
    SP1:              -           -                       -                                   -         
    SP2:              -           -                       -                                   -         
    SP3:              -           -     -                 -                                             
    SP4:                          -     -                                                               
    SP5:              -           -                                                                     


    ECgene alternative splicing isoforms for TALDO1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TALDO1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCGCCTCCT
    TALDO1 Expression
    About this image
    See TALDO1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TALDO1

    SOURCE GeneReport for Unigene cluster: Hs.438678
        SABiosciences Expression via Pathway-Focused PCR Array including TALDO1: 

              Glucose Metabolism in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for TALDO1 gene from 11/37 species (see all 37)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Taldo11 , 5 transaldolase 11, 5 88.13(n)1
    94.36(a)1
      7 (86.73 cM)5
    213511  NM_011528.41  NP_035658.11 
     1413921995 
    chicken
    (Gallus gallus)
    Aves TALDO11 transaldolase 1 77.45(n)
    83.98(a)
      423019  NM_001031177.1  NP_001026348.1 
    lizard
    (Anolis carolinensis)
    Reptilia TALDO16
    --
    83(a)
    1 ↔ 1
    1(73956107-73967192)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.252122 Xenopus laevis transcribed sequence with moderate similarity more 79.06(n)    BX843089.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc32g022 wufc32g02 79.13(n)   324556  BC061957.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Transaldolase3
    Tal1
    pentose-phosphate shunt, non-oxidative
    branch more3
    CG2827-PA1
    66(a)3
    64.61(n)1
    65.74(a)1
      60A123
    378041  NM_079111.21  NP_523835.21 
    worm
    (Caenorhabditis elegans)
    Secernentea Y24D9A.8b3
    Y24D9A.81
    Protein Y24D9A.81 61(a)
    (best of 2)3
    61.53(n)1
    61.64(a)1
      IV(4388414-4388963)3
    1772021  NM_171314.51  NP_741369.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes NQM1(YGR043C)4
    TAL11
    Transaldolase of unknown function; transcription is more4
    Tal1p1
    57.14(n)1
    59.88(a)1
      7(581436-580435)4
    8510681  NP_013458.11  8529344 
     NP_011557.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G122306
    transaldolase
    24(a)
    1 ↔ 1
    1(4147962-4151056)
    rice
    (Oryza sativa)
    Liliopsida --
    transaldolase, putative, expressed
    25(a)
    1 ↔ 1
    8(3127288-3131243)


    ENSEMBL Gene Tree for TALDO1 (if available)
    TreeFam Gene Tree for TALDO1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TALDO1 gene
    2 SIMAP similar genes for TALDO1 using alignment to 5 protein entries:     TALDO_HUMAN (see all proteins):
    NAA25    RBM4

    TALDO1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TALDO1
    PGOHUM00000244729


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/386 NCBI SNPs in TALDO1 are shown (see all 386    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1906344321,2
    --745463(+) CACATA/GCTGAG 1 -- us2k10--------
    rs1829393701,2
    --745557(+) TGTTTA/CTAACC 1 -- us2k10--------
    rs1861549651,2
    --745609(+) GTCTTA/GGGAAG 1 -- us2k10--------
    rs1141161841,2
    F--745660(+) CTAGAC/ATGTTC 1 -- us2k11Minor allele frequency- A:0.08WA 118
    rs1465089151,2
    --745688(+) GGCCAC/TCAGCC 1 -- us2k10--------
    rs1919829321,2
    --745736(+) TATCAA/GCCATT 1 -- us2k10--------
    rs1826528231,2
    --745758(+) CATAAA/GATAAG 1 -- us2k10--------
    rs1152756011,2
    F--745785(+) AGATAT/ACAACA 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1410358521,2
    --745853(+) GCCCAC/GGTTAG 1 -- us2k10--------
    rs1877527361,2
    --745878(+) ATCTCA/GGCTCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TALDO1 (747329 - 765024 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for TALDO1
         3 CNVs: 3831 4725 29883
    Human Gene Mutation Database (HGMD): TALDO1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TALDO1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TALDO1 for disorders           About GeneDecksing

    OMIM gene information: 602063   
    OMIM disorders: 606003  
    UniProtKB/Swiss-Prot: TALDO_HUMAN, P37837
  • Defects in TALDO1 are the cause of transaldolase 1 deficiency (TALDO1 deficiency) [MIM:606003]. It results in
  • telangiectases of the skin, hepatosplenomegaly, and enlarged clitoris

    20 diseases for TALDO1:    About MalaCards
    ribose 5-phosphate isomerase deficiency    multiple sclerosis    transaldolase deficiency    hydrops fetalis
    xeroderma pigmentosum    senile cataract    metabolic disorders    liver cirrhosis
    squamous cell carcinoma of the head and neck    bartter disease    squamous cell carcinoma    cataract
    rheumatoid arthritis    huntington's disease    crohn's disease    arthritis
    cardiomyopathy    obesity    carcinoma    hepatitis

    3 diseases from the University of Copenhagen DISEASES database for TALDO1:
    Hereditary fructose intolerance syndrome     Serine deficiency     Bartter disease

    10/12 Novoseek disease relationships for TALDO1 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    transaldolase deficiency 98.6 19 17603756 (3), 15877206 (2), 15115436 (1), 16435188 (1) (see all 15)
    multiple sclerosis 42.2 17 10491006 (4), 15286385 (3), 9077532 (2), 16339578 (1) (see all 8)
    autoimmunity 40.8 4 15286385 (2), 9077532 (1), 10491006 (1)
    mimicry 38 2 10491006 (1), 7964452 (1)
    demyelination 35.9 6 20194725 (1)
    liver cirrhosis 34.4 7 15115436 (2), 11283793 (1), 14988808 (1), 17613166 (1)
    liver failure 33.2 7 19436114 (2), 15877206 (2), 17095351 (1), 15248099 (1)
    metabolic disorder 21 2 17095351 (1)
    neurological disorders 0 1 7964452 (1)
    necrosis 0 2 8955144 (1), 10765922 (1)

    Human Genome Epidemiology (HuGE) Navigator: TALDO1 (1 document)

    Export disorders for TALDO1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TALDO1 gene, integrated from 9 sources (see all 110):
    (articles sorted by number of sources associating them with TALDO1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human transaldolase gene (TALDO1) is located on chromosome 11 at p15.4-p15.5. (PubMed id 9339383)1, 2, 3, 9 Banki K.... Perl A. (1997)
    2. Cloning and chromosomal localization of a paralog and a mouse homolog of the human transaldolase gene. (PubMed id 9524206)1, 2, 9 Kusuda J....Hashimoto K. (1998)
    3. Cloning and expression of the human gene for transaldolase. A novel highly repetitive element constitutes an integral part of the coding sequence. (PubMed id 8300619)1, 2, 9 Banki K.... Perl A. (1994)
    4. Transaldolase deficiency: liver cirrhosis associated with a new inborn error in the pentose phosphate pathway. (PubMed id 11283793)1, 2, 9 Verhoeven N.M.... Jakobs C. (2001)
    5. The three-dimensional structure of human transaldolase. (PubMed id 10869557)1, 2, 9 Thorell S....Schneider G. (2000)
    6. Human transaldolase-associated repetitive elements are transcribed by RNA polymerase III. (PubMed id 10702296)1, 2, 9 Perl A.... Banki K. (2000)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Oligodendrocyte-specific expression and autoantigenicity of transaldolase in multiple sclerosis. (PubMed id 7964452)1, 9 Banki K....Perl A. (1994)
    9. Cleavage of transaldolase by granzyme B causes the lo ss of enzymatic activity with retention of antigenicity for multiple sclerosis patients. (PubMed id 20194725)1, 9 Niland B....Perl A. (2010)
    10. Transaldolase deficiency influences the pentose phosphate pathway, mitochondrial homoeostasis and apoptosis signal processing. (PubMed id 18498245)1, 9 Qian Y....Perl A. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6888 HGNC: 11559 AceView: TALDO1 Ensembl:ENSG00000177156 euGenes: HUgn6888
    ECgene: TALDO1 Kegg: 6888 H-InvDB: TALDO1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TALDO1 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/TALDO1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TALDO1 gene:
    Search GeneIP for patents involving TALDO1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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