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Aliases & Descriptions for TALDO1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 2.2.1.2 3 | | TAL 2, 3 | | TAL-H 2 | | TALDO 3 | | TALDOR 2, 3 | | TALH 2 |
| | | Descriptions |
|---|
| dihydroxyacetone transferase 2 | | glycerone transferase 2 | | transaldolase 1 2 |
|
| | Search outside databases for aliases for TALDO1 genePrevious GC identifers: GC11U990129 GC11M000780 GC11M000433 GC11P000738 |
Summaries for TALDO1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for TALDO1: Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq] UniProtKB/Swiss-Prot: TALDO_HUMAN, P37837Function: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway |
Genomic Location for TALDO1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the TALDO1 gene 
Entrez Gene cytogenetic band: 11p15.5-p15.4 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5-p15.4TALDO1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P000737:
(about GC identifiers)
Start:
|
737,432 bp from pter |
End:
|
755,024 bp from pter |
Size:
|
17,593 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000011.8 NT_035113.6
| Proteins for TALDO1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: TALDO_HUMAN, P37837 (See
protein sequence)Recommended Name: Transaldolase Size: 337 amino acids; 37540 Da
Subcellular location: Cytoplasm (Probable)
PDB structures from and Proteopedia :1F05 (3D)
 
Secondary accessions: B2R8M2 O00751 Q8WV32Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_006746.1
ENSEMBL proteins: ENSP00000321259
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for TALDO1: Assays for TALDO1: | Protein
Domains/ Families for TALDO1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P37837
ProtoNet protein and cluster: P37837 1 Blocks protein family: IPB001585 Transaldolase
UniProtKB/Swiss-Prot: TALDO_HUMAN, P37837Similarity: Belongs to the transaldolase family. Type 1 subfamily | Gene Function for TALDO1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006755
Applied Biosystems Silencer® siRNAs for TALDO1
Sigma-Aldrich siRNA and siRNA Panels for TALDO1  Sigma-Aldrich shRNA for TALDO1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006755                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006755                                  untagged cDNA clones in CMV expression vector (see all 2): NM_006755 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006755
UniProtKB/Swiss-Prot: TALDO_HUMAN, P37837Function: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathwayCatalytic activity: Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphateEnzyme Number (IUBMB): EC 2.2.1.2 Genatlas biochemistry entry for TALDO1:transaldolase 1,key enzyme of the pentose phosphate pathway,expressed in the oligodendrocyte2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Taldo1):
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for TALDO1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for TALDO1 (Your Favorite Gene powered by Ingenuity) 
UniProtKB/Swiss-Prot: TALDO_HUMAN, P37837Pathway: Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3 5/13 Interacting proteins for TALDO1 (ENSP000003212593 P378371, 2) via UniProtKB, MINT, and/or STRING (see all 13
)About this table
3 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for TALDO1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for TALDO1 10/16 Novoseek chemical compound relationships for TALDO1 gene (see all 16
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| sedoheptulose 7-phosphate |
93.19 |
6 |
15115436 (1), 17603756 (1), 8333192 (1), 16055050 (1) |
| ribose 5-phosphate |
88.29 |
8 |
16435188 (1), 11283793 (1), 12459274 (1), 18987987 (1) (see all 7) |
| 6-phosphogluconate |
75.46 |
6 |
8955144 (2), 2111278 (2), 12215204 (1), 10877828 (1) |
| glucose 6-phosphate |
73.19 |
17 |
8955144 (2), 18183605 (2), 2111278 (2), 9612242 (1) (see all 10) |
| fructose-6-phosphate |
67.86 |
5 |
18687684 (1), 8357848 (1), 19401148 (1), 8487668 (1) (see all 5) |
| glyceraldehyde 3-phosphate |
67.03 |
6 |
18183605 (2), 15840824 (1), 17119969 (1), 17934142 (1) (see all 5) |
| sugar phosphate |
61.19 |
1 |
18183605 (1) |
| nadph |
44.68 |
11 |
8955144 (2), 12459274 (1), 11390181 (1), 9565623 (1) (see all 7) |
| pyruvate |
39.82 |
5 |
16046162 (1), 19149159 (1), 19056584 (1) |
| ribose |
34.17 |
1 |
16046162 (1) |
About this table
|
Transcripts for TALDO1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006755
Sigma-Aldrich siRNA and siRNA Panels for TALDO1  Sigma-Aldrich shRNA for TALDO1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_006755 REFSEQ mRNAs for TALDO1 gene: NM_006755.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006755               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006755                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006755                                  untagged cDNA clones in CMV expression vector (see all 2): NM_006755  Additional cDNA sequence: AK295537.1 AK313427.1 BC009680.2 BC010103.2 BC018847.2 CR599118.1 CR607805.1 CR611492.1 CR619185.1 L19437.2 24/26 DOTS entries (see all 26
): DT.454449 DT.99986732 DT.100678861 DT.100848180 DT.100659500 DT.100678863 DT.91816899 DT.100844032 DT.87079267 DT.91915246 DT.92452561 DT.95376123 DT.120695048 DT.95376116 DT.95376124 DT.100678867 DT.100871008 DT.120695036 DT.95376121 DT.95376125 DT.95376142 DT.97860567 DT.97860568 DT.100757892 24/827 AceView cDNA sequences (see all 827
):BG748022 CA445405 BF725767 BC010103 CB143065 BQ894658 BU685998 BX343264 BU733225 CB126649 AW162169 BM919332 AV713855 CB130232 BQ057940 BQ026736 BU190694 AA306332 BQ067172 AW575982 BQ949141 BM843700 CB113909 BQ226080
highest scoring ESTs for TALDO1:AA079296 AA088409 AA113045 AA128194 AA132751 AA133622 AA135414 AA179439 AA310809 AA329193 Unigene Cluster for TALDO1: Transaldolase 1 Hs.438678 [show with all ESTs]Unigene Representative Sequence: BM804717
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TALDO1 (see all 9
)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9 | |
| SP1: | |   | |   | - |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |
| SP2: | |   | |   | - |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |
| SP3: | |   | |   | - |   | |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for TALDO1
1 Ensembl transcript including schematic representation: ENST00000319006
|
Expression for TALDO1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| TALDO1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for TALDO1
1 / 2 / 3 3 probe-sets matching TALDO1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GGCGCCTCCT
SOURCE GeneReport for Unigene cluster: Hs.438678
Expression variation in blood from EXPOLDB for TALDO1 |
Orthologs for TALDO1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TALDO1 gene from 5/21 species (see all 21
)
About this table Species with no ortholog for TALDO1
ENSEMBL Gene Tree for TALDO1 | Paralogs for TALDO1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for TALDO1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for TALDO1 (up to first 250kb)
|
Disorders & Mutations for TALDO1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 602063 disorders: 606003 UniProtKB/Swiss-Prot: TALDO_HUMAN, P37837
Defects in TALDO1 are the cause of transaldolase 1 deficiency (TALDO1 deficiency) [MIM:606003]. It results in telangiectases of the skin, hepatosplenomegaly, and enlarged clitoris10/11 Novoseek disease relationships for TALDO1 gene (see all 11
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| transaldolase deficiency |
98.71 |
19 |
17603756 (3), 15877206 (2), 15115436 (1), 16435188 (1) (see all 15) |
| mimicry |
40.50 |
2 |
10491006 (1), 7964452 (1) |
| multiple sclerosis |
38.53 |
15 |
10491006 (4), 15286385 (3), 9077532 (2), 16339578 (1) (see all 7) |
| autoimmunity |
33.78 |
4 |
15286385 (2), 9077532 (1), 10491006 (1) |
| liver cirrhosis |
30.13 |
7 |
15115436 (2), 11283793 (1), 14988808 (1), 17613166 (1) |
| liver failure |
27.02 |
5 |
15877206 (2), 17095351 (1), 15248099 (1) |
| metabolic disorder |
24.30 |
2 |
17095351 (1) |
| neurological disorders |
1.15 |
1 |
7964452 (1) |
| necrosis |
0.00 |
2 |
8955144 (1), 10765922 (1) |
| tumors |
0.00 |
2 |
8955144 (1), 10765922 (1) |
About this table
Human Gene Mutation Database: TALDO1 Human Genome Epidemiology Navigator: TALDO1 (1 document)
|
Medical News for TALDO1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for TALDO1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/89 PubMed articles for TALDO1 gene (see all 89
):- The human transaldolase gene (TALDO1) is located on chromosome 11 at p15.4-p15.5. (PubMed id 9339383)1, 2, 3, 4 Banki K.... Perl A. (1997)
- Cloning and chromosomal localization of a paralog and a mouse homolog of the human transaldolase gene. (PubMed id 9524206)1, 3, 4 Kusuda J....Hashimoto K. (1998)
- Cloning and expression of the human gene for transaldolase. A novel highly repetitive element constitutes an integral part of the coding sequence. (PubMed id 8300619)1, 3, 4 Banki K.... Perl A. (1994)
- Transaldolase deficiency: liver cirrhosis associated with a new inborn error in the pentose phosphate pathway. (PubMed id 11283793)1, 3, 4 Verhoeven N.M.... Jakobs C. (2001)
- Human transaldolase-associated repetitive elements are transcribed by RNA polymerase III. (PubMed id 10702296)1, 3, 4 Perl A.... Banki K. (2000)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Oligodendrocyte-specific expression and autoantigenicity of transaldolase in multiple sclerosis. (PubMed id 7964452)1, 3 Banki K....Perl A. (1994)
- Transaldolase deficiency influences the pentose phosphate pathway, mitochondrial homoeostasis and apoptosis signal processing. (PubMed id 18498245)1, 3 Qian Y....Perl A. (2008)
- ZNF143 mediates basal and tissue-specific expression of human transaldolase. (PubMed id 14702349)1, 3 Grossman C.E....Perl A. (2004)
|
Search for TALDO1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TALDO1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing TALDO1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TALDO1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| GeneReviews | http://www.genetests.org/query?gene=TALDO1 |
|
| | | About This Section
| --
| Services for TALDO1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
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