TALDO1 Gene
protein-coding GIFtS: 66
GCID: GC11P000737
|
|
transaldolase 1
| |
Aliases for TALDO1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Transaldolase 11 2 | | TALH2 | | TAL2 3 | | Dihydroxyacetone Transferase2 | | TALDOR2 3 | | Glycerone Transferase2 | | EC 2.2.1.23 8 | | Transaldolase1 | | TAL-H2 | | TALDO3 |
Export aliases for TALDO1 gene to outside databasesPrevious GC identifers: GC11U990129 GC11M000780 GC11M000433 GC11P000738 GC11P000564 |
Summaries for TALDO1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for TALDO1: Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleicacid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state andthus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 islocated on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. Thesecond and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought tobe involved in multiple sclerosis. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: TALDO_HUMAN, P37837Function: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
|
Genomic Views for TALDO1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TALDO1 gene promoter: Pax-5 POU3F1 CUTL1 HNF-3beta YY1 AREB6 SRY FOXO4 FOXJ2 Other transcription factors
Search SABiosciences Chromatin IP Primers for TALDO1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TALDO1 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.5-p15.4 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5-p15.4TALDO1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P000737: view genomic region
(about GC identifiers)
Start:
|
747,329 bp from pter |
End:
|
765,024 bp from pter |
Size:
|
17,696 bases |
Orientation:
|
plus strand |
|
Proteins for TALDO1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: TALDO_HUMAN, P37837 (See
protein sequence)Recommended Name: Transaldolase Size: 337 amino acids; 37540 Da
Subunit: Homodimer
Subcellular location: Cytoplasm (Probable)
1 PDB 3D structure from and Proteopedia for TALDO1:1F05 (3D)
 
Secondary accessions: B2R8M2 O00751 Q8WV32 Q8WZ45Explore the universe of human proteins at neXtProt for TALDO1: NX_P37837
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P37837 4/21 DME Specific Peptides for TALDO1 (P37837) (see all 21)
TALDO1 Protein expression data from MOPED and PaxDb: About this image 
 REFSEQ proteins: NP_006746.1 ENSEMBL proteins: ENSP00000321259 ENSP00000435042 ENSP00000437098 ENSP00000433501 Reactome Protein details: P37837 Human Recombinant Protein Products for TALDO1:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
TALDO1 for ontologies About GeneDecksing
TALDO1 Antibody Products: Assay Products for TALDO1: |
Protein
Domains / Families for TALDO1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TALDO1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P37837ProtoNet protein and cluster: P37837 1 Blocks protein family: IPB001585 Transaldolase
UniProtKB/Swiss-Prot: TALDO_HUMAN, P37837Similarity: Belongs to the transaldolase family. Type 1 subfamily |
Function for TALDO1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Molecular Function: UniProtKB/Swiss-Prot Summary: TALDO_HUMAN, P37837Function: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathwayCatalytic activity: Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose6-phosphate Genatlas biochemistry entry for TALDO1:transaldolase 1,key enzyme of the pentose phosphate pathway,expressed in the oligodendrocyte Enzyme Number (IUBMB): EC 2.2.1.21 2
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003824 | catalytic activity |
-- | -- | | GO:0004801 | sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity |
IEA | -- | | GO:0048029 | monosaccharide binding |
-- | -- |
TALDO1 for ontologies About GeneDecksing
Phenotypes: 1 GenomeRNAi human phenotype for TALDO1: 2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Taldo1):
TALDO1 for phenotypes About GeneDecksing
Animal Models: Mouse knock-out Taldo1tm1Perl for TALDO1
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TALDO1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TALDO1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TALDO1 (NM_006755) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TALDO1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TALDO1  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TALDO1 |
|
Pathways & Interactions for TALDO1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Metabolism | | | 2 | Pentose phosphate pathway (hexose monophosphate shunt) | | | 3 | Insulin effects increased synthesis of Xylulose-5-Phosphate | | | 4 | Pentose phosphate pathway | | | 5 | Regulation of Insulin Secretion | |
Pathway sources See GeneCards unified pathways Show all pathways
1 BioSystems Pathway for TALDO1 
5
Reactome Pathways for TALDO1
2
Kegg Pathways (Kegg details for TALDO1): UniProtKB/Swiss-Prot: TALDO_HUMAN, P37837Pathway: Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3
TALDO1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TALDO1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
 5/79 Interacting proteins for TALDO1 (P378371, 2, 3 ENSP000003212594) via UniProtKB, MINT, STRING, and/or I2D (see all 79) About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005975 | carbohydrate metabolic process |
TAS | -- | | GO:0005999 | xylulose biosynthetic process |
TAS | -- | | GO:0006002 | fructose 6-phosphate metabolic process |
-- | -- | | GO:0006098 | pentose-phosphate shunt |
TAS | -- | | GO:0006112 | energy reserve metabolic process |
TAS | -- |
TALDO1 for ontologies About GeneDecksing
|
Drugs & Compounds for TALDO1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TALDO1 for compounds About GeneDecksing
Browse Tocris compounds for TALDO1
6 HMDB Compounds for TALDO1 About this table 10/29 Novoseek chemical compound relationships for TALDO1 gene (see all 29) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| sedoheptulose 7-phosphate |
93.5 |
6 |
15115436 (1), 17603756 (1), 8333192 (1), 16055050 (1) |
| ribose 5-phosphate |
88.4 |
8 |
16435188 (1), 11283793 (1), 12459274 (1), 18987987 (1) (see all 7) |
| erythritol |
76.8 |
2 |
17095351 (1), 15877206 (1) |
| 6-phosphogluconate |
74.4 |
6 |
8955144 (2), 2111278 (2), 12215204 (1), 10877828 (1) |
| glucose 6-phosphate |
71.9 |
17 |
8955144 (2), 18183605 (2), 2111278 (2), 9612242 (1) (see all 10) |
| fructose-6-phosphate |
70.2 |
6 |
18687684 (1), 19780152 (1), 8357848 (1), 19401148 (1) (see all 6) |
| xylitol |
68.9 |
6 |
17095351 (1), 12555554 (1), 15877206 (1) |
| glyceraldehyde 3-phosphate |
67.2 |
7 |
18183605 (2), 15840824 (1), 17119969 (1), 17934142 (1) (see all 6) |
| fructose-1,6-bisphosphate |
60.6 |
2 |
16834328 (1) |
| sugar phosphate |
59.8 |
1 |
18183605 (1) |
Search CenterWatch for drugs/clinical trials and news about TALDO1 / TALDO 
|
Transcripts for TALDO1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for TALDO1 gene: NM_006755.1 Unigene Cluster for TALDO1: Transaldolase 1 Hs.438678 [show with all ESTs]Unigene Representative Sequence: BM8047179 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000319006(uc001lqz.3 uc001lra.3) ENST00000528070 ENST00000532685 ENST00000528097 ENST00000530440 ENST00000530119(uc010qwl.2) ENST00000533796 ENST00000530666 ENST00000532202
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TALDO1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TALDO1 (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TALDO1 (NM_006755) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TALDO1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TALDO1  |
Additional cDNA sequence: AK295537.1 AK313427.1 BC009680.2 BC010103.2 BC018847.2 L19437.2 24/26 DOTS entries (see all 26): DT.454449 DT.99986732 DT.100678861 DT.100848180 DT.100659500 DT.100678863 DT.91816899 DT.100844032 DT.87079267 DT.92452561 DT.95376123 DT.120695048 DT.91915246 DT.95376116 DT.95376124 DT.100678867 DT.100871008 DT.120695036 DT.95376121 DT.95376142 DT.97860567 DT.97860568 DT.100757892 DT.92452565 24/827 AceView cDNA sequences (see all 827): CB143065 BQ226080 BU624787 F33409 BQ675412 AI038554 BQ026736 BI824002 BM670844 BP352945 CB113127 BU662836 BM842389 BF797380 BQ685791 BU626424 BG289711 BM840504 CB108204 CB108888 BM737969 BQ647989 BP337943 AW406218 GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TALDO1 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9 | |
| SP1: | |   | |   | - |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |
| SP2: | |   | |   | - |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |
| SP3: | |   | |   | - |   | |   | - |   | - |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for TALDO1
|
Expression for TALDO1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TALDO1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GGCGCCTCCT
 About this image See TALDO1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TALDO1
SOURCE GeneReport for Unigene cluster: Hs.438678 SABiosciences Expression via Pathway-Focused PCR Array including TALDO1:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TALDO1 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TALDO1 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TALDO1 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TALDO1 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TALDO1 |
Orthologs for TALDO1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for TALDO1 gene from 11/37 species (see all 37) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
mouse (Mus musculus) |
Mammalia |
Taldo11 , 5 |
transaldolase 11, 5 |
88.13(n)1 94.36(a)1 |
  |
7 (86.73 cM)5 213511 NM_011528.41 NP_035658.11 1413921995 |
chicken (Gallus gallus) |
Aves |
TALDO11 |
transaldolase 1 |
77.45(n) 83.98(a) |
  |
423019 NM_001031177.1 NP_001026348.1 |
lizard (Anolis carolinensis) |
Reptilia |
TALDO16 |
-- |
83(a) |
1 ↔ 1 |
1(73956107-73967192) |
African clawed frog (Xenopus laevis) |
Amphibia |
Xl.252122 |
Xenopus laevis transcribed sequence with moderate similarity more |
79.06(n) |
  |
BX843089.1 |
zebrafish (Danio rerio) |
Actinopterygii |
wufc32g022 |
wufc32g02 |
79.13(n) |
  |
324556 BC061957.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
Transaldolase3 Tal1 |
pentose-phosphate shunt, non-oxidative branch more3 CG2827-PA1 |
66(a)3 64.61(n)1 65.74(a)1 |
  |
60A123 378041 NM_079111.21 NP_523835.21 |
worm (Caenorhabditis elegans) |
Secernentea |
Y24D9A.8b3 Y24D9A.81 |
Protein Y24D9A.81 |
61(a) (best of 2)3 61.53(n)1 61.64(a)1 |
  |
IV(4388414-4388963)3 1772021 NM_171314.51 NP_741369.11 |
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes |
NQM1(YGR043C)4 TAL11 |
Transaldolase of unknown function; transcription is more4 Tal1p1 |
57.14(n)1 59.88(a)1 |
  |
7(581436-580435)4 8510681 NP_013458.11 8529344 NP_011557.14 |
thale cress (Arabidopsis thaliana) |
eudicotyledons |
AT1G122306 |
transaldolase |
24(a) |
1 ↔ 1 |
1(4147962-4151056) |
rice (Oryza sativa) |
Liliopsida |
-- |
transaldolase, putative, expressed |
25(a) |
1 ↔ 1 |
8(3127288-3131243) |
ENSEMBL Gene Tree for TALDO1 (if available) TreeFam Gene Tree for TALDO1 (if available)  |
Paralogs for TALDO1 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for TALDO1 gene
2 SIMAP similar genes for TALDO1 using alignment to 5 protein entries: TALDO_HUMAN (see all proteins):NAA25 RBM4
TALDO1 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TALDO1 PGOHUM00000244729
|
Genomic Variants for TALDO1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 11 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for TALDO1 (747329 - 765024 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 3 variations for TALDO1 3 CNVs: 3831 4725 29883 Human Gene Mutation Database (HGMD): TALDO1
 | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TALDO1 |
|
Disorders
/ Diseases for TALDO1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TALDO1 for disorders About GeneDecksing
OMIM gene information: 602063 OMIM disorders: 606003 UniProtKB/Swiss-Prot: TALDO_HUMAN, P37837
Defects in TALDO1 are the cause of transaldolase 1 deficiency (TALDO1 deficiency) [MIM:606003]. It results intelangiectases of the skin, hepatosplenomegaly, and enlarged clitoris 20 diseases for TALDO1: About MalaCardsribose 5-phosphate isomerase deficiency multiple sclerosis transaldolase deficiency hydrops fetalis xeroderma pigmentosum senile cataract metabolic disorders liver cirrhosis squamous cell carcinoma of the head and neck bartter disease squamous cell carcinoma cataract rheumatoid arthritis huntington's disease crohn's disease arthritis cardiomyopathy obesity carcinoma hepatitis 3 diseases from the University of Copenhagen DISEASES database for TALDO1:Hereditary fructose intolerance syndrome Serine deficiency Bartter disease 10/12 Novoseek disease relationships for TALDO1 gene (see all 12) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| transaldolase deficiency |
98.6 |
19 |
17603756 (3), 15877206 (2), 15115436 (1), 16435188 (1) (see all 15) |
| multiple sclerosis |
42.2 |
17 |
10491006 (4), 15286385 (3), 9077532 (2), 16339578 (1) (see all 8) |
| autoimmunity |
40.8 |
4 |
15286385 (2), 9077532 (1), 10491006 (1) |
| mimicry |
38 |
2 |
10491006 (1), 7964452 (1) |
| demyelination |
35.9 |
6 |
20194725 (1) |
| liver cirrhosis |
34.4 |
7 |
15115436 (2), 11283793 (1), 14988808 (1), 17613166 (1) |
| liver failure |
33.2 |
7 |
19436114 (2), 15877206 (2), 17095351 (1), 15248099 (1) |
| metabolic disorder |
21 |
2 |
17095351 (1) |
| neurological disorders |
0 |
1 |
7964452 (1) |
| necrosis |
0 |
2 |
8955144 (1), 10765922 (1) |
Human Genome Epidemiology (HuGE) Navigator: TALDO1 (1 document) Export disorders for TALDO1 gene to outside databases
|
Publications for TALDO1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for TALDO1 gene, integrated from 9 sources (see all 110): (articles sorted by number of sources associating them with TALDO1) | |  | Utopia: connect your pdf to the dynamic world of online information |
- The human transaldolase gene (TALDO1) is located on chromosome 11 at p15.4-p15.5. (PubMed id 9339383)1, 2, 3, 9 Banki K.... Perl A. (1997)
- Cloning and chromosomal localization of a paralog and a mouse homolog of the human transaldolase gene. (PubMed id 9524206)1, 2, 9 Kusuda J....Hashimoto K. (1998)
- Cloning and expression of the human gene for transaldolase. A novel highly repetitive element constitutes an integral part of the coding sequence. (PubMed id 8300619)1, 2, 9 Banki K.... Perl A. (1994)
- Transaldolase deficiency: liver cirrhosis associated with a new inborn error in the pentose phosphate pathway. (PubMed id 11283793)1, 2, 9 Verhoeven N.M.... Jakobs C. (2001)
- The three-dimensional structure of human transaldolase. (PubMed id 10869557)1, 2, 9 Thorell S....Schneider G. (2000)
- Human transaldolase-associated repetitive elements are transcribed by RNA polymerase III. (PubMed id 10702296)1, 2, 9 Perl A.... Banki K. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Oligodendrocyte-specific expression and autoantigenicity of transaldolase in multiple sclerosis. (PubMed id 7964452)1, 9 Banki K....Perl A. (1994)
- Cleavage of transaldolase by granzyme B causes the lo ss of enzymatic activity with retention of antigenicity for multiple sclerosis patients. (PubMed id 20194725)1, 9 Niland B....Perl A. (2010)
- Transaldolase deficiency influences the pentose phosphate pathway, mitochondrial homoeostasis and apoptosis signal processing. (PubMed id 18498245)1, 9 Qian Y....Perl A. (2008)
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External Searches for TALDO1 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing TALDO1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing TALDO1 gene
(According to HUGE)
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Specialized Databases showing TALDO1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
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| Name | Description |
| PharmGKB entry for TALDO1 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/TALDO1 |
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| Patent Information for TALDO1 gene: Search GeneIP for patents involving TALDO1
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products for TALDO1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory) About This Section
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