Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TALDO1 Gene

Aliases for TALDO1 Gene

  • Transaldolase 1 2 3
  • EC 4 63
  • TALDOR 3 4
  • TAL 3 4
  • Dihydroxyacetone Transferase 3
  • Glycerone Transferase 3
  • TAL-H 3
  • TALDO 4
  • TALH 3

External Ids for TALDO1 Gene

Previous GeneCards Identifiers for TALDO1 Gene

  • GC11U990129
  • GC11M000780
  • GC11M000433
  • GC11P000738
  • GC11P000737
  • GC11P000564

Summaries for TALDO1 Gene

Entrez Gene Summary for TALDO1 Gene

  • Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for TALDO1 Gene

TALDO1 (Transaldolase 1) is a Protein Coding gene. Diseases associated with TALDO1 include transaldolase deficiency and ribose 5-phosphate isomerase deficiency. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity.

UniProtKB/Swiss-Prot for TALDO1 Gene

  • Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TALDO1 Gene

Genomics for TALDO1 Gene

Regulatory Elements for TALDO1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TALDO1 Gene

747,329 bp from pter
765,024 bp from pter
17,696 bases
Plus strand

Genomic View for TALDO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TALDO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TALDO1 Gene

Proteins for TALDO1 Gene

  • Protein details for TALDO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B2R8M2
    • O00751
    • Q8WV32
    • Q8WZ45

    Protein attributes for TALDO1 Gene

    337 amino acids
    Molecular mass:
    37540 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for TALDO1 Gene

neXtProt entry for TALDO1 Gene

Proteomics data for TALDO1 Gene at MOPED

Post-translational modifications for TALDO1 Gene

  • Ubiquitination at Lys 115, Lys 130, Lys 219, Lys 230, Lys 269, Lys 277, and Lys 307
  • Modification sites at PhosphoSitePlus

Other Protein References for TALDO1 Gene

Antibody Products

Domains & Families for TALDO1 Gene

Protein Domains for TALDO1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the transaldolase family. Type 1 subfamily.
  • Belongs to the transaldolase family. Type 1 subfamily.
genes like me logo Genes that share domains with TALDO1: view

No data available for Gene Families for TALDO1 Gene

Function for TALDO1 Gene

Molecular function for TALDO1 Gene

GENATLAS Biochemistry:
transaldolase 1,key enzyme of the pentose phosphate pathway,expressed in the oligodendrocyte
UniProtKB/Swiss-Prot CatalyticActivity:
Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate
UniProtKB/Swiss-Prot Function:
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway

Enzyme Numbers (IUBMB) for TALDO1 Gene

Gene Ontology (GO) - Molecular Function for TALDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004801 sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity EXP --
GO:0030246 carbohydrate binding --
GO:0048029 monosaccharide binding IEA --
genes like me logo Genes that share ontologies with TALDO1: view
genes like me logo Genes that share phenotypes with TALDO1: view

Animal Models for TALDO1 Gene

MGI Knock Outs for TALDO1:

miRNA for TALDO1 Gene

miRTarBase miRNAs that target TALDO1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TALDO1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for TALDO1 Gene

Localization for TALDO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TALDO1 Gene


Subcellular locations from

Jensen Localization Image for TALDO1 Gene COMPARTMENTS Subcellular localization image for TALDO1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
golgi apparatus 2
chloroplast 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TALDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm TAS 16130169
GO:0005829 cytosol TAS --
GO:0043231 intracellular membrane-bounded organelle --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with TALDO1: view

Pathways & Interactions for TALDO1 Gene

genes like me logo Genes that share pathways with TALDO1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot P37837-TALDO_HUMAN

  • Pathway: Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3

Gene Ontology (GO) - Biological Process for TALDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0005999 xylulose biosynthetic process TAS --
GO:0006002 fructose 6-phosphate metabolic process IEA --
GO:0006098 pentose-phosphate shunt TAS --
GO:0006112 energy reserve metabolic process TAS --
genes like me logo Genes that share ontologies with TALDO1: view

No data available for SIGNOR curated interactions for TALDO1 Gene

Drugs & Compounds for TALDO1 Gene

(16) Drugs for TALDO1 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zolpidem Approved Pharma Full agonist, Allosteric regulator 91
Mannitol Approved, Investigational Pharma 220
Phosphatidylserine Approved Nutra 0
Thiamine Approved Nutra 82,82
Vitamin C Approved Nutra 398,398

(20) Additional Compounds for TALDO1 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Beta-D-Fructose 6-phosphate
  • beta-D-Fructose 6-phosphate
D-Erythrose 4-phosphate
  • D-Erythrose 4-phosphate
  • D-Erythrose 4-PO4
  • D-Erythrose-4-P
  • D-Erythrose-4-phosphate
  • Erythrose 4-phosphate
D-Sedoheptulose 7-phosphate
  • 7-(Dihydrogen phosphate) sedoheptulose
  • D-Sedoheptulose 7-phosphate
  • D-Sedoheptulose-7-p
  • D-Sedoheptulose-7-phosphate
  • Heptulose-7-phosphate
Fructose 6-phosphate
  • D-Fructose 6-phosphate
  • D-Fructose 6-phosphorate
  • D-Fructose 6-phosphoric acid
  • D-Fructose-6-P
  • D-Fructose-6-phosphate
  • Altro-Heptulose
  • D-Altro-2-heptulose
  • D-Altro-hept-2-ulose
  • Volemulose
genes like me logo Genes that share compounds with TALDO1: view

Transcripts for TALDO1 Gene

Unigene Clusters for TALDO1 Gene

Transaldolase 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TALDO1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TALDO1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - -
SP5: - -
SP6: - - - - -
SP9: -

Relevant External Links for TALDO1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TALDO1 Gene

mRNA expression in normal human tissues for TALDO1 Gene

mRNA differential expression in normal tissues according to GTEx for TALDO1 Gene

This gene is overexpressed in Whole Blood (x12.7).

Protein differential expression in normal tissues from HIPED for TALDO1 Gene

This gene is overexpressed in Lymph node (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TALDO1 Gene

SOURCE GeneReport for Unigene cluster for TALDO1 Gene Hs.438678

genes like me logo Genes that share expression patterns with TALDO1: view

Protein tissue co-expression partners for TALDO1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TALDO1 Gene

Orthologs for TALDO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TALDO1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TALDO1 35
  • 88.63 (n)
  • 93.77 (a)
  • 94 (a)
(Canis familiaris)
Mammalia TALDO1 35
  • 87.04 (n)
  • 95.25 (a)
-- 36
  • 95 (a)
-- 36
  • 95 (a)
(Mus musculus)
Mammalia Taldo1 35
  • 88.13 (n)
  • 94.36 (a)
Taldo1 16
Taldo1 36
  • 94 (a)
(Pan troglodytes)
Mammalia TALDO1 35
  • 99.41 (n)
  • 99.41 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Taldo1 35
  • 87.54 (n)
  • 94.66 (a)
(Monodelphis domestica)
Mammalia TALDO1 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia TALDO1 36
  • 87 (a)
(Gallus gallus)
Aves TALDO1 35
  • 77.45 (n)
  • 83.98 (a)
  • 85 (a)
(Anolis carolinensis)
Reptilia TALDO1 36
  • 83 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1274 35
taldo1 35
  • 73.79 (n)
  • 83.68 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.25212 35
(Danio rerio)
Actinopterygii taldo1 35
  • 73.49 (n)
  • 76.85 (a)
wufc32g02 35
taldo1 36
  • 77 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9766 35
fruit fly
(Drosophila melanogaster)
Insecta Transaldolase 37
  • 66 (a)
Tal 35
  • 64.61 (n)
  • 65.74 (a)
Tal 36
  • 64 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011800 35
  • 66.56 (n)
  • 67.69 (a)
(Caenorhabditis elegans)
Secernentea Y24D9A.8a 37
  • 61 (a)
Y24D9A.8b 37
  • 61 (a)
Y24D9A.8 35
  • 61.53 (n)
  • 61.64 (a)
Y24D9A.8 36
  • 62 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL196W 35
  • 61.6 (n)
  • 62.31 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A02607g 35
  • 57.75 (n)
  • 61.09 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAL1 35
  • 57.04 (n)
  • 59.88 (a)
NQM1 36
  • 56 (a)
TAL1 36
  • 58 (a)
NQM1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G12230 35
  • 46.75 (n)
  • 35.06 (a)
(Oryza sativa)
Liliopsida Os08g0154300 35
  • 47.98 (n)
  • 36.69 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.70 35
bread mold
(Neurospora crassa)
Ascomycetes NCU02136 35
  • 63.32 (n)
  • 58.93 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tal1 35
  • 60 (n)
  • 60.63 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.567 36
  • 67 (a)
Species with no ortholog for TALDO1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TALDO1 Gene

Gene Tree for TALDO1 (if available)
Gene Tree for TALDO1 (if available)

Paralogs for TALDO1 Gene

(2) SIMAP similar genes for TALDO1 Gene using alignment to 5 proteins: Pseudogenes for TALDO1 Gene

genes like me logo Genes that share paralogs with TALDO1: view

No data available for Paralogs for TALDO1 Gene

Variants for TALDO1 Gene

Sequence variations from dbSNP and Humsavar for TALDO1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs4821 -- 760,245(+) ATTCA(G/T)GCTGG reference, missense
rs11302 -- 764,414(+) AGTGA(A/C/G/T)GCTGG reference, missense
rs1050401 -- 764,964(+) GATTT(C/T)TGATT utr-variant-3-prime
rs1131117 -- 764,872(+) CAGAT(C/T)TGCAC utr-variant-3-prime
rs1131125 -- 764,912(+) GGCTT(C/T)TGATG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TALDO1 Gene

Variant ID Type Subtype PubMed ID
dgv182e199 CNV Deletion 23128226
dgv921n71 CNV Loss 21882294
nsv469923 CNV Loss 18288195
essv23843 CNV CNV 17122850
dgv936n71 CNV Loss 21882294
nsv832043 CNV Loss 17160897
dgv943n71 CNV Loss 21882294
dgv944n71 CNV Loss 21882294
nsv522733 CNV Loss 19592680
dgv945n71 CNV Loss 21882294
nsv896583 CNV Gain 21882294
dgv946n71 CNV Loss 21882294
nsv896587 CNV Loss 21882294
esv2661152 CNV Deletion 23128226
nsv825682 CNV Gain 20364138
nsv8758 CNV Gain 18304495

Variation tolerance for TALDO1 Gene

Residual Variation Intolerance Score: 46.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.34; 41.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TALDO1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TALDO1 Gene

Disorders for TALDO1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for TALDO1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
transaldolase deficiency
  • taldo
ribose 5-phosphate isomerase deficiency
  • rpid
fructose intolerance
  • hereditary fructose intolerance syndrome
serine deficiency
senile cataract
- elite association


  • Transaldolase deficiency (TALDOD) [MIM:606003]: An inborn error of the pentose phosphate pathway resulting in early-onset multisystem disease. Clinical features include growth retardation, dysmorphic features, cutis laxa, congenital heart disease, hepatosplenomegaly, telangiectases of the skin, pancytopenia, and bleeding tendency. {ECO:0000269 PubMed:11283793}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TALDO1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TALDO1: view

No data available for Genatlas for TALDO1 Gene

Publications for TALDO1 Gene

  1. The human transaldolase gene (TALDO1) is located on chromosome 11 at p15.4-p15.5. (PMID: 9339383) Banki K. … Perl A. (Genomics 1997) 2 23 67
  2. Identification of seroreactive proteins in the culture filtrate antigen of Mycobacterium avium ssp. paratuberculosis human isolates to sera from Crohn's disease patients. (PMID: 19878316) Shin A.R. … Shin S.J. (FEMS Immunol. Med. Microbiol. 2010) 23 67
  3. Cleavage of transaldolase by granzyme B causes the loss of enzymatic activity with retention of antigenicity for multiple sclerosis patients. (PMID: 20194725) Niland B. … Perl A. (J. Immunol. 2010) 23 67
  4. Changes in the transcriptome of abdominal subcutaneous adipose tissue in response to short-term overfeeding in lean and obese men. (PMID: 19056584) Shea J. … Sun G. (Am. J. Clin. Nutr. 2009) 23 67
  5. Transaldolase deficiency in two new patients with a relative mild phenotype. (PMID: 19299175) Tylki-SzymaA8ska A. … Jakobs C. (Mol. Genet. Metab. 2009) 23 67

Products for TALDO1 Gene

Sources for TALDO1 Gene

Back to Top