Aliases for TALDO1 Gene
External Ids for TALDO1 Gene
Previous GeneCards Identifiers for TALDO1 Gene
Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008]
GeneCards Summary for TALDO1 Gene
TALDO1 (Transaldolase 1) is a Protein Coding gene. Diseases associated with TALDO1 include Transaldolase Deficiency and Ribose 5-Phosphate Isomerase Deficiency. Among its related pathways are Glycosaminoglycan metabolism and Pentose phosphate pathway. GO annotations related to this gene include sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity.
UniProtKB/Swiss-Prot for TALDO1 Gene
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.