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Aliases for TALDO1 Gene

Aliases for TALDO1 Gene

  • Transaldolase 1 2 3
  • EC 2.2.1.2 4 63
  • TALDOR 3 4
  • TAL 3 4
  • Dihydroxyacetone Transferase 3
  • Glycerone Transferase 3
  • Transaldolase 3
  • TAL-H 3
  • TALDO 4
  • TALH 3

External Ids for TALDO1 Gene

Previous GeneCards Identifiers for TALDO1 Gene

  • GC11U990129
  • GC11M000780
  • GC11M000433
  • GC11P000738
  • GC11P000737
  • GC11P000564

Summaries for TALDO1 Gene

Entrez Gene Summary for TALDO1 Gene

  • Transaldolase 1 is a key enzyme of the nonoxidative pentose phosphate pathway providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway can also maintain glutathione at a reduced state and thus protect sulfhydryl groups and cellular integrity from oxygen radicals. The functional gene of transaldolase 1 is located on chromosome 11 and a pseudogene is identified on chromosome 1 but there are conflicting map locations. The second and third exon of this gene were developed by insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for TALDO1 Gene

TALDO1 (Transaldolase 1) is a Protein Coding gene. Diseases associated with TALDO1 include transaldolase deficiency and fructose intolerance. Among its related pathways are Metabolism and Carbon metabolism. GO annotations related to this gene include sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity.

UniProtKB/Swiss-Prot for TALDO1 Gene

  • Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TALDO1 Gene

Genomics for TALDO1 Gene

Regulatory Elements for TALDO1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TALDO1 Gene

Start:
747,329 bp from pter
End:
765,024 bp from pter
Size:
17,696 bases
Orientation:
Plus strand

Genomic View for TALDO1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TALDO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TALDO1 Gene

Proteins for TALDO1 Gene

  • Protein details for TALDO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P37837-TALDO_HUMAN
    Recommended name:
    Transaldolase
    Protein Accession:
    P37837
    Secondary Accessions:
    • B2R8M2
    • O00751
    • Q8WV32
    • Q8WZ45

    Protein attributes for TALDO1 Gene

    Size:
    337 amino acids
    Molecular mass:
    37540 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for TALDO1 Gene

neXtProt entry for TALDO1 Gene

Proteomics data for TALDO1 Gene at MOPED

Post-translational modifications for TALDO1 Gene

  • Ubiquitination at Lys115, Lys130, Lys219, Lys230, Lys269, Lys277, Lys307, and Lys321
  • Modification sites at PhosphoSitePlus

Other Protein References for TALDO1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for TALDO1 Gene

Protein Domains for TALDO1 Gene

Suggested Antigen Peptide Sequences for TALDO1 Gene

Graphical View of Domain Structure for InterPro Entry

P37837

UniProtKB/Swiss-Prot:

TALDO_HUMAN :
  • P37837
Family:
  • Belongs to the transaldolase family. Type 1 subfamily.
genes like me logo Genes that share domains with TALDO1: view

No data available for Gene Families for TALDO1 Gene

Function for TALDO1 Gene

Molecular function for TALDO1 Gene

GENATLAS Biochemistry: transaldolase 1,key enzyme of the pentose phosphate pathway,expressed in the oligodendrocyte
UniProtKB/Swiss-Prot CatalyticActivity: Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate
UniProtKB/Swiss-Prot Function: Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway

Enzyme Numbers (IUBMB) for TALDO1 Gene

Gene Ontology (GO) - Molecular Function for TALDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004801 sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity EXP --
genes like me logo Genes that share ontologies with TALDO1: view

Phenotypes for TALDO1 Gene

genes like me logo Genes that share phenotypes with TALDO1: view

Animal Models for TALDO1 Gene

MGI Knock Outs for TALDO1:

Animal Model Products

miRNA for TALDO1 Gene

miRTarBase miRNAs that target TALDO1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TALDO1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for TALDO1 Gene

Localization for TALDO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TALDO1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TALDO1 Gene COMPARTMENTS Subcellular localization image for TALDO1 gene
Compartment Confidence
cytosol 4
mitochondrion 2
extracellular 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TALDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm TAS 16130169
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with TALDO1: view

Pathways for TALDO1 Gene

genes like me logo Genes that share pathways with TALDO1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot P37837-TALDO_HUMAN

  • Pathway: Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3

Gene Ontology (GO) - Biological Process for TALDO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0005999 xylulose biosynthetic process TAS --
GO:0006098 pentose-phosphate shunt TAS --
GO:0006112 energy reserve metabolic process TAS --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with TALDO1: view

Compounds for TALDO1 Gene

(6) HMDB Compounds for TALDO1 Gene

Compound Synonyms Cas Number PubMed IDs
D-Erythrose 4-phosphate
  • D-Erythrose 4-phosphate
585-18-2
D-Glyceraldehyde 3-phosphate
  • 2-hydroxy-3-(phosphonooxy)-Propanal
142-10-9
D-Sedoheptulose 7-phosphate
  • 7-(dihydrogen phosphate) sedoheptulose
2646-35-7
Fructose 6-phosphate
  • D-Fructose 6-phosphate
643-13-0
Sedoheptulose
  • D-Altro-2-heptulose
3019-74-7

(29) Novoseek inferred chemical compound relationships for TALDO1 Gene

Compound -log(P) Hits PubMed IDs
sedoheptulose 7-phosphate 93.5 4
ribose 5-phosphate 88.4 7
erythritol 76.8 2
6-phosphogluconate 74.4 6
glucose 6-phosphate 71.9 13
genes like me logo Genes that share compounds with TALDO1: view

Transcripts for TALDO1 Gene

Unigene Clusters for TALDO1 Gene

Transaldolase 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TALDO1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TALDO1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - -
SP5: - -
SP6: - - - - -
SP7:
SP8:
SP9: -

Relevant External Links for TALDO1 Gene

GeneLoc Exon Structure for
TALDO1
ECgene alternative splicing isoforms for
TALDO1

Expression for TALDO1 Gene

mRNA expression in normal human tissues for TALDO1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TALDO1 Gene

This gene is overexpressed in Whole Blood (12.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TALDO1 Gene

SOURCE GeneReport for Unigene cluster for TALDO1 Gene Hs.438678

genes like me logo Genes that share expressions with TALDO1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TALDO1 Gene

Orthologs for TALDO1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TALDO1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TALDO1 35
  • 99.41 (n)
  • 99.41 (a)
TALDO1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TALDO1 35
  • 88.63 (n)
  • 93.77 (a)
TALDO1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 95 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
TALDO1 35
  • 87.04 (n)
  • 95.25 (a)
mouse
(Mus musculus)
Mammalia Taldo1 35
  • 88.13 (n)
  • 94.36 (a)
Taldo1 16
Taldo1 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TALDO1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TALDO1 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Taldo1 35
  • 87.54 (n)
  • 94.66 (a)
chicken
(Gallus gallus)
Aves TALDO1 35
  • 77.45 (n)
  • 83.98 (a)
TALDO1 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TALDO1 36
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25212 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1274 35
taldo1 35
  • 73.79 (n)
  • 83.68 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9766 35
zebrafish
(Danio rerio)
Actinopterygii taldo1 35
  • 73.49 (n)
  • 76.85 (a)
taldo1 36
  • 77 (a)
OneToOne
wufc32g02 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011800 35
  • 66.56 (n)
  • 67.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta Tal 35
  • 64.61 (n)
  • 65.74 (a)
Tal 36
  • 64 (a)
OneToOne
Transaldolase 37
  • 66 (a)
worm
(Caenorhabditis elegans)
Secernentea Y24D9A.8 35
  • 61.53 (n)
  • 61.64 (a)
Y24D9A.8 36
  • 62 (a)
OneToOne
Y24D9A.8b 37
  • 61 (a)
Y24D9A.8a 37
  • 61 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL196W 35
  • 61.6 (n)
  • 62.31 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NQM1 36
  • 56 (a)
OneToMany
NQM1 38
TAL1 35
  • 57.04 (n)
  • 59.88 (a)
TAL1 36
  • 58 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A02607g 35
  • 57.75 (n)
  • 61.09 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G12230 35
  • 46.75 (n)
  • 35.06 (a)
rice
(Oryza sativa)
Liliopsida Os08g0154300 35
  • 47.98 (n)
  • 36.69 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02136 35
  • 63.32 (n)
  • 58.93 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tal1 35
  • 60 (n)
  • 60.63 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.70 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.567 36
  • 67 (a)
OneToOne
Species with no ortholog for TALDO1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TALDO1 Gene

ENSEMBL:
Gene Tree for TALDO1 (if available)
TreeFam:
Gene Tree for TALDO1 (if available)

Paralogs for TALDO1 Gene

Selected SIMAP similar genes for TALDO1 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for TALDO1 Gene

genes like me logo Genes that share paralogs with TALDO1: view

No data available for Paralogs for TALDO1 Gene

Variants for TALDO1 Gene

Sequence variations from dbSNP and Humsavar for TALDO1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs4821 -- 760,245(+) ATTCA(G/T)GCTGG reference, missense
rs11302 -- 764,414(+) AGTGA(A/C/G/T)GCTGG reference, missense
rs1050401 -- 764,964(+) GATTT(C/T)TGATT utr-variant-3-prime
rs1131117 -- 764,872(+) CAGAT(C/T)TGCAC utr-variant-3-prime
rs1131125 -- 764,912(+) GGCTT(C/T)TGATG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TALDO1 Gene

Variant ID Type Subtype PubMed ID
dgv182e199 CNV Deletion 23128226
dgv921n71 CNV Loss 21882294
nsv469923 CNV Loss 18288195
essv23843 CNV CNV 17122850
dgv936n71 CNV Loss 21882294
nsv832043 CNV Loss 17160897
dgv943n71 CNV Loss 21882294
dgv944n71 CNV Loss 21882294
nsv522733 CNV Loss 19592680
dgv945n71 CNV Loss 21882294
nsv896583 CNV Gain 21882294
dgv946n71 CNV Loss 21882294
nsv896587 CNV Loss 21882294
esv2661152 CNV Deletion 23128226
nsv825682 CNV Gain 20364138
nsv8758 CNV Gain 18304495

Relevant External Links for TALDO1 Gene

HapMap Linkage Disequilibrium report
TALDO1
Human Gene Mutation Database (HGMD)
TALDO1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TALDO1 Gene

Disorders for TALDO1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for TALDO1 Gene including...

Search for TALDO1 Gene in MalaCards »

(1) OMIM Diseases for TALDO1 Gene (602063)

UniProtKB/Swiss-Prot

TALDO_HUMAN
  • Transaldolase deficiency (TALDOD) [MIM:606003]: An inborn error of the pentose phosphate pathway resulting in early-onset multisystem disease. Clinical features include growth retardation, dysmorphic features, cutis laxa, congenital heart disease, hepatosplenomegaly, telangiectases of the skin, pancytopenia, and bleeding tendency. {ECO:0000269 PubMed:11283793}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(3) University of Copenhagen DISEASES for TALDO1 Gene

(12) Novoseek inferred disease relationships for TALDO1 Gene

Disease -log(P) Hits PubMed IDs
transaldolase deficiency 98.6 18
multiple sclerosis 42.2 14
autoimmunity 40.8 4
mimicry 38 2
demyelination 35.9 1

Relevant External Links for TALDO1

Genetic Association Database (GAD)
TALDO1
Human Genome Epidemiology (HuGE) Navigator
TALDO1
genes like me logo Genes that share disorders with TALDO1: view

Publications for TALDO1 Gene

  1. The human transaldolase gene (TALDO1) is located on chromosome 11 at p15.4-p15.5. (PMID: 9339383) Banki K. … Perl A. (Genomics 1997) 2 3 4 23
  2. Cloning and chromosomal localization of a paralog and a mouse homolog of the human transaldolase gene. (PMID: 9524206) Kusuda J. … Hashimoto K. (Gene 1998) 3 4 23
  3. Cloning and expression of the human gene for transaldolase. A novel highly repetitive element constitutes an integral part of the coding sequence. (PMID: 8300619) Banki K. … Perl A. (J. Biol. Chem. 1994) 3 4 23
  4. Transaldolase deficiency: liver cirrhosis associated with a new inborn error in the pentose phosphate pathway. (PMID: 11283793) Verhoeven N.M. … Jakobs C. (Am. J. Hum. Genet. 2001) 3 4 23
  5. Human transaldolase-associated repetitive elements are transcribed by RNA polymerase III. (PMID: 10702296) Perl A. … Banki K. (J. Biol. Chem. 2000) 3 4 23

Products for TALDO1 Gene

Sources for TALDO1 Gene

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