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Aliases for TAL2 Gene

Aliases for TAL2 Gene

  • TAL BHLH Transcription Factor 2 2 3 5
  • Class A Basic Helix-Loop-Helix Protein 19 3 4
  • T-Cell Acute Lymphocytic Leukemia 2 2 3
  • TAL-2 3 4
  • T-Cell Acute Lymphocytic Leukemia Protein 2 3
  • BHLHA19 4

External Ids for TAL2 Gene

Previous GeneCards Identifiers for TAL2 Gene

  • GC09P099225
  • GC09P100168
  • GC09P101882
  • GC09P103804
  • GC09P105504
  • GC09P107464
  • GC09P108424
  • GC09P078026

Summaries for TAL2 Gene

Entrez Gene Summary for TAL2 Gene

  • This intronless gene encodes a helix-loop-helix protein. Translocations between this gene on chromosome 9 and the T-cell receptor beta-chain locus on chromosome 7 have been associated with activation of the T-cell acute lymphocytic leukemia 2 gene and T-cell acute lymphoblastic leukemia. [provided by RefSeq, Mar 2009]

GeneCards Summary for TAL2 Gene

TAL2 (TAL BHLH Transcription Factor 2) is a Protein Coding gene. Diseases associated with TAL2 include Leukemia, Acute Lymphoblastic and Acute Lymphocytic Leukemia. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is TAL1.

Gene Wiki entry for TAL2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAL2 Gene

Genomics for TAL2 Gene

Regulatory Elements for TAL2 Gene

Enhancers for TAL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F106054 0.4 FANTOM5 18.3 +392.2 392240 0.2 TAL2 ENSG00000225002 LOC105376201
GH09F105683 0.6 ENCODE 12.1 +21.6 21599 1.2 ELF3 TFAP4 ATF1 SAP130 MLX DMAP1 CEBPG ZNF644 THRB TEAD3 TMEM38B TAL2
GH09F105609 0.5 ENCODE 11.6 -53.3 -53283 0.2 CTCF PKNOX1 ZNF654 PBX2 SMC3 TRIM22 REST RAD21 TAL2 GC09M105565 ENSG00000279609
GH09F105860 0.3 FANTOM5 6.4 +198.4 198416 0.3 PBX2 TAL2 FSD1L SLC25A6P5 ENSG00000234323
GH09F105216 1 FANTOM5 Ensembl 1.6 -445.6 -445632 0.5 SOX13 SOX5 ZNF48 RAD21 YY1 SLC44A1 TAL2 FSD1L GC09P105218 RN7SKP191
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TAL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAL2 Gene

Chromosome:
9
Start:
105,662,457 bp from pter
End:
105,663,112 bp from pter
Size:
656 bases
Orientation:
Plus strand

Genomic View for TAL2 Gene

Genes around TAL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAL2 Gene

Proteins for TAL2 Gene

  • Protein details for TAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16559-TAL2_HUMAN
    Recommended name:
    T-cell acute lymphocytic leukemia protein 2
    Protein Accession:
    Q16559
    Secondary Accessions:
    • A0AVI7

    Protein attributes for TAL2 Gene

    Size:
    108 amino acids
    Molecular mass:
    12291 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TAL2 Gene

Post-translational modifications for TAL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAL2 Gene

Domains & Families for TAL2 Gene

Gene Families for TAL2 Gene

Protein Domains for TAL2 Gene

Suggested Antigen Peptide Sequences for TAL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16559

UniProtKB/Swiss-Prot:

TAL2_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with TAL2: view

Function for TAL2 Gene

Molecular function for TAL2 Gene

GENATLAS Biochemistry:
helix loop helix protein,homologous to TAL1,involved in T cell acute lymphoblastic leukemia,with translocation t(7;9)(q35;q34)

Gene Ontology (GO) - Molecular Function for TAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003677 DNA binding TAS 1763056
GO:0005515 protein binding IPI 25416956
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with TAL2: view
genes like me logo Genes that share phenotypes with TAL2: view

Human Phenotype Ontology for TAL2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TAL2 Gene

MGI Knock Outs for TAL2:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TAL2 Gene

Localization for TAL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAL2 Gene COMPARTMENTS Subcellular localization image for TAL2 gene
Compartment Confidence
nucleus 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with TAL2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TAL2 Gene

Pathways & Interactions for TAL2 Gene

SuperPathways for TAL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
GO:0009791 post-embryonic development IEA --
GO:0021794 thalamus development IEA --
genes like me logo Genes that share ontologies with TAL2: view

No data available for Pathways by source and SIGNOR curated interactions for TAL2 Gene

Transcripts for TAL2 Gene

mRNA/cDNA for TAL2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAL2 Gene

T-cell acute lymphocytic leukemia 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAL2 Gene

No ASD Table

Relevant External Links for TAL2 Gene

GeneLoc Exon Structure for
TAL2
ECgene alternative splicing isoforms for
TAL2

Expression for TAL2 Gene

mRNA expression in normal human tissues for TAL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TAL2 Gene

This gene is overexpressed in Muscle - Skeletal (x8.5).

NURSA nuclear receptor signaling pathways regulating expression of TAL2 Gene:

TAL2

SOURCE GeneReport for Unigene cluster for TAL2 Gene:

Hs.247978
genes like me logo Genes that share expression patterns with TAL2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TAL2 Gene

Orthologs for TAL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TAL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAL2 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia TAL2 34 35
  • 91.75 (n)
cow
(Bos Taurus)
Mammalia TAL2 34 35
  • 90.16 (n)
mouse
(Mus musculus)
Mammalia Tal2 34 16 35
  • 86.11 (n)
rat
(Rattus norvegicus)
Mammalia Tal2 34
  • 85.19 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TAL2 35
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAL2 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAL2 35
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAL2 35
  • 78 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tal2 34 35
  • 60.78 (n)
fruit fly
(Drosophila melanogaster)
Insecta HLH3B 35
  • 14 (a)
OneToMany
Species where no ortholog for TAL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAL2 Gene

ENSEMBL:
Gene Tree for TAL2 (if available)
TreeFam:
Gene Tree for TAL2 (if available)

Paralogs for TAL2 Gene

Paralogs for TAL2 Gene

(23) SIMAP similar genes for TAL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TAL2: view

Variants for TAL2 Gene

Sequence variations from dbSNP and Humsavar for TAL2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10816291 -- 105,660,651(+) CCCCC(A/C/G)ACTTG upstream-variant-2KB
rs10816292 -- 105,661,085(+) GAAAG(G/T)GTAGA upstream-variant-2KB
rs10978181 -- 105,660,497(+) tgatt(C/T)ttctg upstream-variant-2KB
rs10978182 -- 105,661,386(+) GCCCC(A/G)AAGAG upstream-variant-2KB
rs10978183 -- 105,661,792(+) GGGTG(A/G)ATCAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TAL2 Gene

Variant ID Type Subtype PubMed ID
esv3891705 CNV loss 25118596
esv3891707 CNV gain 25118596
nsv519023 CNV gain 19592680

Variation tolerance for TAL2 Gene

Residual Variation Intolerance Score: 83.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 22.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAL2 Gene

Disorders for TAL2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TAL2 Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
leukemia, acute lymphoblastic
  • leukemia, t-cell acute lymphocytic, somatic
acute lymphocytic leukemia
  • acute lymphoblastic leukemia
leukemia
lymphoblastic leukemia
  • acute lymphocytic leukemia
- elite association - COSMIC cancer census association via MalaCards
Search TAL2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TAL2_HUMAN
  • Note=A chromosomal aberration involving TAL2 may be a cause of some T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;9)(q34;q32) with TCRB. {ECO:0000269 PubMed:1763056}.

Genatlas disease for TAL2 Gene

acute lymphoblastic leukemia (T cell) with breakpoint in t(7;9)(q35;q34) translocation

Relevant External Links for TAL2

Genetic Association Database (GAD)
TAL2
Tumor Gene Database (TGDB):
TAL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAL2
genes like me logo Genes that share disorders with TAL2: view

Publications for TAL2 Gene

  1. TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia. (PMID: 1763056) Xia Y. … Baer R.J. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 3 4 22 64
  2. Products of the TAL2 oncogene in leukemic T cells: bHLH phosphoproteins with DNA-binding activity. (PMID: 8152805) Xia Y. … Baer R. (Oncogene 1994) 3 4 22 64
  3. Common genetic variation and performance on standardized cognitive tests. (PMID: 20125193) Cirulli E.T. … Goldstein D.B. (Eur. J. Hum. Genet. 2010) 3 46 64
  4. Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. (PMID: 19448620) Perry J.R. … Murabito J.M. (Nat. Genet. 2009) 3 46 64
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4 64

Products for TAL2 Gene

Sources for TAL2 Gene

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