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Aliases for TAL2 Gene

Aliases for TAL2 Gene

  • T-Cell Acute Lymphocytic Leukemia 2 2 3
  • Class A Basic Helix-Loop-Helix Protein 19 3 4
  • TAL-2 3 4
  • BHLHA19 4

External Ids for TAL2 Gene

Previous GeneCards Identifiers for TAL2 Gene

  • GC09P099225
  • GC09P100168
  • GC09P101882
  • GC09P103804
  • GC09P105504
  • GC09P107464
  • GC09P108424
  • GC09P078026

Summaries for TAL2 Gene

Entrez Gene Summary for TAL2 Gene

  • This intronless gene encodes a helix-loop-helix protein. Translocations between this gene on chromosome 9 and the T-cell receptor beta-chain locus on chromosome 7 have been associated with activation of the T-cell acute lymphocytic leukemia 2 gene and T-cell acute lymphoblastic leukemia. [provided by RefSeq, Mar 2009]

GeneCards Summary for TAL2 Gene

TAL2 (T-Cell Acute Lymphocytic Leukemia 2) is a Protein Coding gene. Diseases associated with TAL2 include acute lymphocytic leukemia and leukemia, acute lymphoblastic. GO annotations related to this gene include protein dimerization activity. An important paralog of this gene is LYL1.

Gene Wiki entry for TAL2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAL2 Gene

Genomics for TAL2 Gene

Regulatory Elements for TAL2 Gene

Genomic Location for TAL2 Gene

Chromosome:
9
Start:
105,662,457 bp from pter
End:
105,663,112 bp from pter
Size:
656 bases
Orientation:
Plus strand

Genomic View for TAL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAL2 Gene

Proteins for TAL2 Gene

  • Protein details for TAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16559-TAL2_HUMAN
    Recommended name:
    T-cell acute lymphocytic leukemia protein 2
    Protein Accession:
    Q16559
    Secondary Accessions:
    • A0AVI7

    Protein attributes for TAL2 Gene

    Size:
    108 amino acids
    Molecular mass:
    12291 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TAL2 Gene

Proteomics data for TAL2 Gene at MOPED

Post-translational modifications for TAL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAL2 Gene

Domains & Families for TAL2 Gene

Gene Families for TAL2 Gene

Protein Domains for TAL2 Gene

Suggested Antigen Peptide Sequences for TAL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q16559

UniProtKB/Swiss-Prot:

TAL2_HUMAN :
  • Contains 1 bHLH (basic helix-loop-helix) domain.
Domain:
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with TAL2: view

Function for TAL2 Gene

Molecular function for TAL2 Gene

GENATLAS Biochemistry:
helix loop helix protein,homologous to TAL1,involved in T cell acute lymphoblastic leukemia,with translocation t(7;9)(q35;q34)

Gene Ontology (GO) - Molecular Function for TAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003677 DNA binding TAS 1763056
GO:0005515 protein binding IPI 25416956
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with TAL2: view
genes like me logo Genes that share phenotypes with TAL2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAL2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TAL2 Gene

Localization for TAL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAL2 Gene COMPARTMENTS Subcellular localization image for TAL2 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for TAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with TAL2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TAL2 Gene

Pathways & Interactions for TAL2 Gene

SuperPathways for TAL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0009791 post-embryonic development IEA --
GO:0021794 thalamus development IEA --
GO:0030901 midbrain development IEA --
genes like me logo Genes that share ontologies with TAL2: view

No data available for Pathways by source and SIGNOR curated interactions for TAL2 Gene

Drugs & Compounds for TAL2 Gene

No Compound Related Data Available

Transcripts for TAL2 Gene

mRNA/cDNA for TAL2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAL2 Gene

T-cell acute lymphocytic leukemia 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAL2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAL2 Gene

No ASD Table

Relevant External Links for TAL2 Gene

GeneLoc Exon Structure for
TAL2
ECgene alternative splicing isoforms for
TAL2

Expression for TAL2 Gene

mRNA expression in normal human tissues for TAL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TAL2 Gene

This gene is overexpressed in Muscle - Skeletal (x8.5).

SOURCE GeneReport for Unigene cluster for TAL2 Gene Hs.247978

genes like me logo Genes that share expression patterns with TAL2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TAL2 Gene

Orthologs for TAL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for TAL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TAL2 35
  • 90.16 (n)
  • 95.24 (a)
TAL2 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAL2 35
  • 91.75 (n)
  • 94.06 (a)
TAL2 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tal2 35
  • 86.11 (n)
  • 86.11 (a)
Tal2 16
Tal2 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TAL2 35
  • 100 (n)
  • 100 (a)
TAL2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tal2 35
  • 85.19 (n)
  • 85.19 (a)
oppossum
(Monodelphis domestica)
Mammalia TAL2 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAL2 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAL2 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAL2 36
  • 78 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tal2 35
  • 60.78 (n)
  • 61.76 (a)
tal2 36
  • 50 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta HLH3B 36
  • 14 (a)
OneToMany
Species with no ortholog for TAL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAL2 Gene

ENSEMBL:
Gene Tree for TAL2 (if available)
TreeFam:
Gene Tree for TAL2 (if available)

Paralogs for TAL2 Gene

Paralogs for TAL2 Gene

(23) SIMAP similar genes for TAL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TAL2: view

Variants for TAL2 Gene

Sequence variations from dbSNP and Humsavar for TAL2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs652574 -- 105,660,545(+) CCACC(A/G)CGCCC upstream-variant-2KB
rs7027450 -- 105,663,101(+) TCTAA(A/G)TAAAA utr-variant-3-prime
rs7041188 -- 105,660,636(+) CTGCC(A/G)CCCCC upstream-variant-2KB
rs7041949 -- 105,660,916(+) TTGGA(A/G)CCTGT upstream-variant-2KB
rs7851062 -- 105,662,011(+) ACTCC(A/G)TCTCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TAL2 Gene

Variant ID Type Subtype PubMed ID
nsv519023 CNV Gain 19592680

Variation tolerance for TAL2 Gene

Residual Variation Intolerance Score: 83.34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 22.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAL2 Gene

HapMap Linkage Disequilibrium report
TAL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAL2 Gene

Disorders for TAL2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TAL2 Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
acute lymphocytic leukemia
  • acute lymphoblastic leukemia
leukemia, acute lymphoblastic
  • leukemia, t-cell acute lymphocytic, somatic
lymphoblastic leukemia
  • acute lymphocytic leukemia
leukemia
- elite association
Search TAL2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TAL2_HUMAN
  • Note=A chromosomal aberration involving TAL2 may be a cause of some T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(7;9)(q34;q32) with TCRB.

Genatlas disease for TAL2 Gene

acute lymphoblastic leukemia (T cell) with breakpoint in t(7;9)(q35;q34) translocation

Relevant External Links for TAL2

Genetic Association Database (GAD)
TAL2
Tumor Gene Database (TGDB):
TAL2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAL2
genes like me logo Genes that share disorders with TAL2: view

Publications for TAL2 Gene

  1. TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia. (PMID: 1763056) Xia Y. … Baer R.J. (Proc. Natl. Acad. Sci. U.S.A. 1991) 2 23 67
  2. Products of the TAL2 oncogene in leukemic T cells: bHLH phosphoproteins with DNA-binding activity. (PMID: 8152805) Xia Y. … Baer R. (Oncogene 1994) 23 67
  3. TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins implicated in T cell acute leukaemia. (PMID: 8142619) Baer R. (Semin. Cancer Biol. 1993) 23 67
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  5. The T-cell oncogene Tal2 Is a Target of PU.1 and upregulated during osteoclastogenesis. (PMID: 24086757) Courtial N. … Lausen J. (PLoS ONE 2013) 67

Products for TAL2 Gene

Sources for TAL2 Gene

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