V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

TAL1 Gene

protein-coding   GIFtS: 60

GC01M047454
T-cell acute lymphocytic leukemia 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: TCL5)
Services    

Aliases &
Descriptions
for TAL1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
OTTHUMP00000009563 2
OTTHUMP00000009564 2
SCL 1, 2, 3, 5
TAL-1 3
TCL5 2, 3, 5
bHLHa17 1, 2
tal-1 2
Descriptions
Stem cell protein 3
T-cell acute lymphocytic leukemia 1 2
T-cell leukemia/lymphoma protein 5 3
tal-1 product 2
External Ids
HGNC: 115561
Entrez Gene: 68862
UniProtKB: P175423
Ensembl: ENSG000001623677
Search outside databases for aliases for TAL1 gene

Previous GC identifers: GC01M047308 GC01M046571 GC01M047040 GC01M047051 GC01M047393

Summaries
for TAL1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TAL1_HUMAN, P17542
Function: Implicated in the genesis of hemopoietic malignancies. It may play an important role in
hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By
similarity)

Gene Wiki entry for TAL1

Genomic Location
for TAL1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the TAL1 gene  

Entrez Gene cytogenetic band: 1p32   Ensembl cytogenetic band:  1p33   HGNC cytogenetic band: 1p32

TAL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M047454:     (about GC identifiers)

Start:
 47,454,550 bp from pter
End:
 47,469,974 bp from pter
Size:
 15,425 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000001.9  NT_032977.8  

Proteins
for TAL1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: TAL1_HUMAN, P17542 (See protein sequence)
Recommended Name: T-cell acute lymphocytic leukemia protein 1  
Size: 331 amino acids; 34271 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers
with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex
with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3
(By similarity)
Subcellular location: Nucleus (By similarity)
Alternative splicing: 3 isoforms:  P17542-1   P17542-2   P17542-3   (The splicing pattern is cell-lineage dependent)

Post-translational modifications:

  • Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia (By
    similarity)1
  • Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets
    the protein for rapid degradation via the ubiquitin system. This process may be characteristic for
    microvascular endothelial cells, since it could not be observed in large vessel endothelial cells
    (By similarity)1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_003180.1  

    ENSEMBL proteins: 
    ENSP00000360951 ENSP00000294339 ENSP00000360950 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Tal1)
    Browse Abnova for Human Recombinant Proteins
                  OriGene Purified Recombinant Human Protein: TAL1 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus ISS--
    About this table

    Antibodies for TAL1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for TAL1
    R&D Systems Antibodies for TAL1 (SCL/Tal1)
    Antibodies from Abcam (Tal1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (TAL1)
    Search Novus for antibodies for TAL1

    Assays for TAL1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for TAL1

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro domains/families:
     IPR001092 HLH_basic
     IPR011598 HLH_DNA_bd


       GeneDecks  TAL1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P17542

    ProtoNet protein and cluster: P17542

    1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: TAL1_HUMAN, P17542
    Domain: The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1
    Similarity: Contains 1 basic helix-loop-helix (bHLH) domain

    Gene Function
    for TAL1

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (TAL1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (TAL1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003189

                  Applied Biosystems Silencer® siRNAs for TAL1

                  Sigma-Aldrich siRNA for TAL1  
                         Sigma-Aldrich shRNA Panels and shRNA for TAL1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_003189
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_003189
                                     untagged cDNA clone in CMV expression vector: NM_003189 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_003189

    UniProtKB/Swiss-Prot: TAL1_HUMAN, P17542
    Function: Implicated in the genesis of hemopoietic malignancies. It may play an important role in
    hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By
    similarity)

    12 MGI mutant phenotypes (inferred from 7 alleles) (MGI details for Tal1):

    cellularembryogenesisgrowth/sizehematopoietic system
    homeostasis/metabolismimmune systemlethality-prenatal/perinatallife span-post-weaning/agingnervous system
    skeletonskin/coat/nails

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding TAS2303035
    GO:0005515 protein binding IPI9824680 17474147
    GO:0030528 transcription regulator activity IEA--
    About this table

    Pathways & Interactions
    for TAL1

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


     Gene Network CentralTM Interacting Genes and Proteins Network for  TAL1 


    5/35 Interacting proteins for TAL1 (ENSP000003609503 P175421) via UniProtKB, MINT, and/or STRING (see all 35 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TCF4P158841STRING (score=.998) EBI-1753878, EBI-533224
    CRKP461081EBI-1753878, EBI-886
    DRG1Q9Y2951EBI-1753878, EBI-719554
    LMO1ENSP000003382073STRING (score=.999)
    LMO2ENSP000002578183STRING (score=.999)
    About this table

    4 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    GO:0007275 multicellular organismal development IEA--
    GO:0008283 cell proliferation TAS2303035
    GO:0030154 cell differentiation IEA--
    About this table

    Drugs & Compounds
    for TAL1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for TAL1
    2 Novoseek chemical compound relationships for TAL1 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    tal 2 89.64 10 1763056 (3), 8142619 (3), 7957052 (3), 14975618 (1)
    oligonucleotide 0.00 1 16621969 (1)
    About this table


    Transcripts
    for TAL1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (TAL1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (TAL1)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003189

                  Sigma-Aldrich siRNA for TAL1  
                         Sigma-Aldrich shRNA Panels and shRNA for TAL1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_003189  

    REFSEQ mRNAs for TAL1 gene: 

    NM_003189.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_003189  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_003189
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_003189
                                     untagged cDNA clone in CMV expression vector: NM_003189 

    Additional cDNA sequence: 

    BC144215.1 M29038.1 M61108.1 S53245.1 X51990.1 

    5 DOTS entries:

    DT.87016392  DT.87016391  DT.100752475  DT.121402140  DT.99999943 

    24/61 AceView cDNA sequences (see all 61 ):

    S53686 S53691 CR624822 S53678 BU687269 W01885 AA699603 AI076543 
    M61108 H43303 AW300901 NM_003189 W01051 CB044957 W04962 BX449186 
    CK300042 N71056 AI333301 BU678016 S53245 AA252051 AI123881 BV199247 

    highest scoring ESTs for TAL1:

    H43302 H43303 H56303 N74206 S53678 S53691 T97441 W01051 W01885 AA677998 

    Unigene Cluster for TAL1:

    T-cell acute lymphocytic leukemia 1
    Hs.709194  [show with all ESTs]
    Unigene Representative Sequence: NM_003189


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TAL1

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7
    SP1:              -                             -         
    SP2:                                            -         
    SP3:        -     -     -     -                 -         
    SP4:                                                      

    About this scheme

    ECgene alternative splicing isoforms for TAL1

    3 Ensembl transcripts including schematic representations:
    ENST00000371884  ENST00000294339  ENST00000371883  

    Expression
    for TAL1

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    TAL1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for TAL1

    1 / 2 / 3

    6 probe-sets matching TAL1 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    560_s_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 M63589 0.20 1.00 0.72 1

    		206283_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_003189 0.40 0.67 0.55 1

    		216925_s_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --

    		206283_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		216925_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		1561651_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  TAL1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TGGTGATGAT

    SOURCE GeneReport for Unigene cluster: Hs.709194

    Expression variation in blood from EXPOLDB for TAL1

    UniProtKB/Swiss-Prot: TAL1_HUMAN, P17542
    Tissue specificity: Leukemic stem cell

    Orthologs
    for TAL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for TAL1 gene from 5/9 species (see all 9 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 TAL11   -- T-cell acute lymphocytic leukemia 1 89.81(n)
    93.88(a)    		 610331  XM_847810.1  XP_852903.1 
    chimpanzee
    (Pan troglodytes)    		 TAL11   -- T-cell acute lymphocytic leukemia 1 99.9(n)
    99.7(a)    		 456836  XM_001163354.1  XP_001163354.1 
    cow
    (Bos taurus)    		 TAL11   -- T-cell acute lymphocytic leukemia 1 92.25(n)
    95.72(a)    		 518657  XM_596853.3  XP_596853.2 
    rat
    (Rattus norvegicus)    		 Tal11   -- T-cell acute lymphocytic leukemia 1 88.15(n)
    92.38(a)    		 313507  XM_233430.4  XP_233430.2 
    mouse
    (Mus musculus)    		 Tal11, 5 4 (49.50 cM)5
    		 T-cell acute lymphocytic leukemia 11, 5 88.96(n)1
    93.62(a)1    		 213491  NM_011527.21  NP_035657.11 
     AJ1310175  AJ2971315  (see all 11)
    About this table        Species with no ortholog for TAL1

    ENSEMBL Gene Tree for TAL1

    Paralogs
    for TAL1

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for TAL1 gene
    NHLH12  NHLH22  LYL12  TAL22  

    SNPs/Variants
    for TAL1

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/84 NCBI SNPs in TAL1 are shown (see all 84 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 60)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs20709301,2
    		A,C,F,H47456051(-) TTCACC/TGTGGA 1 -- ut31 ese39Minor allele frequency- T:0.27EA EU WA 1578
    rs76641,2
    		A,C,F,H47454604(-) TGTGTA/CTATAT 1 -- ut31 ese310Minor allele frequency- C:0.15MN EA NA WA 2372
    rs20709291,2
    		A,C,F,H47456194(-) AGGCTC/GTCCAT 1 -- ut3113Minor allele frequency- G:0.47EA EU WA 2752
    rs9777471,2
    		A,C,F,H47457264(-) GAGACA/CATGTC 1 -- ut31 ese35Minor allele frequency- C:0.31MN EU EA WA 602
    rs27983551,2
    		C,F47454313(-) CCCCTC/TGGCTT 1 -- ng514Minor allele frequency- N:0.01EA NA 216
    rs27587421,2
    		C,F47454366(-) CCTCCA/CCAGGG 1 -- ng514Minor allele frequency- C:0.27EA NA 1640
    rs118095551,2
    		F,H47467770(+) CCAACC/TTGCAG 1 -- ut51 ese32Minor allele frequency- T:0.05EA 178
    rs66958981,2
    		C47454348(+) GGAGAA/GAAAGA 1 -- ng510--------
    rs10108121,2
    		F47456753(-) CTGGGA/GGGTTG 1 -- ut31 ese34Minor allele frequency- G:0.06EA NA MN 228
    --
    rs67028491,2
    		C47456415(+) CCACAA/GGCTAT 1 -- ut31 ese30--------
    About this table

    HapMap Linkage Disequilibrium images for TAL1 (up to first 250kb)

    Disorders & Mutations
    for TAL1

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 187040

    UniProtKB/Swiss-Prot: TAL1_HUMAN, P17542

  • A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic
    leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes

    • 10/19 Novoseek disease relationships for TAL1 gene (see all 19 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    t-all 95.35 185 9695959 (7), 8208530 (6), 7605997 (5), 9020185 (5) (see all 65)
    t-cell childhood acute lymphoblastic leukemia 83.23 4 9597892 (1), 9950206 (1), 8471769 (1), 8321044 (1)
    leukemia t-cell 74.02 16 16778171 (2), 10625632 (2), 1382561 (1), 9931488 (1) (see all 12)
    leukemogenesis 71.89 9 8437851 (1), 8289805 (1), 7774592 (1), 9020185 (1) (see all 7)
    erythroleukemia 69.28 12 10688671 (2), 1453013 (1), 8943307 (1), 9699481 (1) (see all 6)
    minimal residual disease 68.34 6 10049045 (2), 9950206 (1), 11243385 (1), 11839375 (1)
    leukemia 61.87 26 2040693 (2), 8778337 (2), 7824274 (2), 15917481 (1) (see all 19)
    acute leukemia 60.26 11 10049045 (2), 1311214 (1), 15917481 (1), 8142619 (1) (see all 8)
    leukaemia lymphocytic 53.93 4 2000219 (1), 11839375 (1), 8547631 (1), 8895560 (1)
    lymphoma lymphoblastic 46.95 4 9116269 (1), 9171354 (1)
    About this table

    Genatlas disease: TAL1
    acute lymphoblastic leukemia (T cell) with interstitial deletion 5' to TAL1 (stem-cell leukemia)
    or with translocations t(1;14)(p32;q11),t(1;7)(p32;p35),t(1;3)(p34;p21),t(1;5)(p32;q31),see
    SCL,SIL,TCTA

    Tumor Gene Database: TAL1

    Medical News
    for TAL1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for TAL1

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/183 PubMed articles for TAL1 gene (see all 183 ):

    Search for TAL1

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TAL1

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 6886 HGNC: 11556 AceView: TAL1 Ensembl:ENSG00000162367 euGenes: HUgn6886
    ECgene: TAL1 H-InvDB: TAL1

    Other Databases showing TAL1

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing TAL1

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for TAL1 Genetics and Cytogenetics in Oncology and Haematology

    Licensable Technologies
    for TAL1

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for TAL1

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for TAL1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for TAL1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for TAL1 Antibodies for TAL1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for TAL1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Search for Recombinant Proteins
     Antibodies (TAL1)
     Chimera RNAi (TAL1)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (Tal1)
     Antibodies (Tal1)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for TAL1




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for TAL1

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

    Random Gene From GIFtS : about GIFtS

    Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

    Developed at the Crown Human Genome Center & Weizmann Institute of Science



    The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
    TAL1 Gene at Home site.
    Version 2.41.1
    server4.xennexinc.com