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Aliases for TAL1 Gene

Aliases for TAL1 Gene

  • T-Cell Acute Lymphocytic Leukemia 1 2 3 5
  • Class A Basic Helix-Loop-Helix Protein 17 3 4
  • T-Cell Leukemia/Lymphoma Protein 5 3 4
  • Stem Cell Protein 3 4
  • BHLHa17 3 4
  • Tal-1 3 4
  • TCL5 3 4
  • SCL 3 4
  • Tal-1 Product 3

External Ids for TAL1 Gene

Previous HGNC Symbols for TAL1 Gene

  • TCL5

Previous GeneCards Identifiers for TAL1 Gene

  • GC01M047308
  • GC01M046571
  • GC01M047040
  • GC01M047051
  • GC01M047393
  • GC01M047454
  • GC01M047681
  • GC01M045798

Summaries for TAL1 Gene

GeneCards Summary for TAL1 Gene

TAL1 (T-Cell Acute Lymphocytic Leukemia 1) is a Protein Coding gene. Diseases associated with TAL1 include leukemia, acute lymphoblastic and precursor t-cell acute lymphoblastic leukemia. Among its related pathways are NF-kappaB Signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is LYL1.

UniProtKB/Swiss-Prot for TAL1 Gene

  • Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).

Gene Wiki entry for TAL1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAL1 Gene

Genomics for TAL1 Gene

Regulatory Elements for TAL1 Gene

Enhancers for TAL1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TAL1 on UCSC Golden Path with GeneCards custom track

Promoters for TAL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TAL1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TAL1 gene promoter:

Genomic Location for TAL1 Gene

Chromosome:
1
Start:
47,216,290 bp from pter
End:
47,232,373 bp from pter
Size:
16,084 bases
Orientation:
Minus strand

Genomic View for TAL1 Gene

Genes around TAL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAL1 Gene

Proteins for TAL1 Gene

  • Protein details for TAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17542-TAL1_HUMAN
    Recommended name:
    T-cell acute lymphocytic leukemia protein 1
    Protein Accession:
    P17542
    Secondary Accessions:
    • D3DQ24

    Protein attributes for TAL1 Gene

    Size:
    331 amino acids
    Molecular mass:
    34271 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3. Interacts with SBNO2; this interaction inhibits TAL1 occupancy of the DCSTAMP promoter, leading to the activation of the DCSTAMP promoter by the transcription factor MITF.

    Three dimensional structures from OCA and Proteopedia for TAL1 Gene

    Alternative splice isoforms for TAL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAL1 Gene

Proteomics data for TAL1 Gene at MOPED

Post-translational modifications for TAL1 Gene

  • Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia (By similarity).
  • Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells (By similarity).
  • Ubiquitination at Lys 185, Lys 234, and Lys 241
  • Modification sites at PhosphoSitePlus

Other Protein References for TAL1 Gene

No data available for DME Specific Peptides for TAL1 Gene

Domains & Families for TAL1 Gene

Gene Families for TAL1 Gene

Protein Domains for TAL1 Gene

Suggested Antigen Peptide Sequences for TAL1 Gene

Graphical View of Domain Structure for InterPro Entry

P17542

UniProtKB/Swiss-Prot:

TAL1_HUMAN :
  • The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.
Domain:
  • The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with TAL1: view

Function for TAL1 Gene

Molecular function for TAL1 Gene

UniProtKB/Swiss-Prot Function:
Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).

Gene Ontology (GO) - Molecular Function for TAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding IEA,IDA 16763211
GO:0044212 transcription regulatory region DNA binding IEA,ISS --
GO:0046983 protein dimerization activity IEA --
genes like me logo Genes that share ontologies with TAL1: view
genes like me logo Genes that share phenotypes with TAL1: view

Human Phenotype Ontology for TAL1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TAL1 Gene

MGI Knock Outs for TAL1:

Animal Model Products

Transcription Factor Targets for TAL1 Gene

Selected GeneGlobe predicted Target genes for TAL1
Targeted motifs for TAL1 Gene
HOMER Transcription Factor Regulatory Elements motif TAL1
  • Consensus sequence: ANCAGCTG Submotif: canonical Cell Type: HPC7 GEO ID: GSE13511

No data available for Enzyme Numbers (IUBMB) for TAL1 Gene

Localization for TAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAL1 Gene COMPARTMENTS Subcellular localization image for TAL1 gene
Compartment Confidence
nucleus 5
cytosol 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for TAL1 Gene

Pathways & Interactions for TAL1 Gene

SuperPathways for TAL1 Gene

Superpath Contained pathways
1 NF-kappaB Signaling
genes like me logo Genes that share pathways with TAL1: view

Pathways by source for TAL1 Gene

1 Cell Signaling Technology pathway for TAL1 Gene

SIGNOR curated interactions for TAL1 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA,ISS --
GO:0030182 neuron differentiation IEA --
GO:0030220 platelet formation IEA --
GO:0030221 basophil differentiation IEP 7678994
genes like me logo Genes that share ontologies with TAL1: view

Drugs & Compounds for TAL1 Gene

(2) Drugs for TAL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for TAL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TAL1: view

Transcripts for TAL1 Gene

Unigene Clusters for TAL1 Gene

T-cell acute lymphocytic leukemia 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAL1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: - -
SP2: -
SP3: - - - - -
SP4:

Relevant External Links for TAL1 Gene

GeneLoc Exon Structure for
TAL1
ECgene alternative splicing isoforms for
TAL1

Expression for TAL1 Gene

mRNA expression in normal human tissues for TAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TAL1 Gene

This gene is overexpressed in Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for TAL1 Gene

This gene is overexpressed in Liver (62.4) and Fetal Liver (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAL1 Gene



SOURCE GeneReport for Unigene cluster for TAL1 Gene Hs.705618

mRNA Expression by UniProt/SwissProt for TAL1 Gene

P17542-TAL1_HUMAN
Tissue specificity: Leukemic stem cell.
genes like me logo Genes that share expression patterns with TAL1: view

Protein tissue co-expression partners for TAL1 Gene

Primer Products

Orthologs for TAL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TAL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TAL1 35
  • 90.52 (n)
  • 92.97 (a)
TAL1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAL1 35
  • 90.42 (n)
  • 93.27 (a)
TAL1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tal1 35
  • 88.75 (n)
  • 93.31 (a)
Tal1 16
Tal1 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TAL1 35
  • 99.9 (n)
  • 99.7 (a)
TAL1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tal1 35
  • 88.05 (n)
  • 94.81 (a)
oppossum
(Monodelphis domestica)
Mammalia TAL1 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAL1 36
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAL1 35
  • 72.46 (n)
  • 70.57 (a)
SCL 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAL1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tal1 35
  • 68.45 (n)
  • 72.32 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398028 35
zebrafish
(Danio rerio)
Actinopterygii tal1 35
  • 68.73 (n)
  • 65.89 (a)
tal1 36
  • 55 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12172 35
fruit fly
(Drosophila melanogaster)
Insecta HLH3B 36
  • 19 (a)
OneToMany
Species with no ortholog for TAL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAL1 Gene

ENSEMBL:
Gene Tree for TAL1 (if available)
TreeFam:
Gene Tree for TAL1 (if available)

Paralogs for TAL1 Gene

Paralogs for TAL1 Gene

(4) SIMAP similar genes for TAL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TAL1: view

Variants for TAL1 Gene

Sequence variations from dbSNP and Humsavar for TAL1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2845 -- 47,228,408(+) GAATC(A/G)TTCTA intron-variant
rs7664 -- 47,216,345(-) TGTGT(A/C)TATAT utr-variant-3-prime
rs741958 -- 47,226,609(-) GGGCA(A/G)AGGAC intron-variant
rs743269 -- 47,225,705(+) GCCGC(C/G)CCCCG intron-variant, reference, missense
rs751852 -- 47,225,750(+) CTCCG(C/T)TGCGG intron-variant, reference, missense

Variation tolerance for TAL1 Gene

Residual Variation Intolerance Score: 64.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.46; 43.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAL1 Gene

HapMap Linkage Disequilibrium report
TAL1
Human Gene Mutation Database (HGMD)
TAL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TAL1 Gene

Disorders for TAL1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for TAL1 Gene - From: OMIM, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
leukemia, acute lymphoblastic
  • leukemia, t-cell acute lymphocytic, somatic
precursor t-cell acute lymphoblastic leukemia
  • precursor t-cell acute lymphoblastic leukemia/lymphoma
t-cell acute lymphocytic leukemia-1
acute lymphocytic leukemia
  • acute lymphoblastic leukemia
leukemia
- elite association - COSMIC cancer census association via MalaCards
Search TAL1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TAL1_HUMAN
  • Note=A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes. {ECO:0000269 PubMed:2303035}.

Genatlas disease for TAL1 Gene

acute lymphoblastic leukemia (T cell) with interstitial deletion 5 to TAL1 (stem-cell leukemia) or with translocations t(1;14)(p32;q11),t(1;7)(p32;p35),t(1;3)(p34;p21),t(1;5)(p32;q31),see SCL,SIL,TCTA

Relevant External Links for TAL1

Genetic Association Database (GAD)
TAL1
Human Genome Epidemiology (HuGE) Navigator
TAL1
Tumor Gene Database (TGDB):
TAL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAL1
genes like me logo Genes that share disorders with TAL1: view

Publications for TAL1 Gene

  1. The SCL gene product: a positive regulator of erythroid differentiation. (PMID: 1396592) Aplan P.D. … Kirsch I.R. (EMBO J. 1992) 3 4 23 67
  2. Targets of the Tal1 transcription factor in erythrocytes: E2 ubiquitin conjugase regulation by Tal1. (PMID: 20028976) Lausen J. … Leutz A. (J. Biol. Chem. 2010) 3 23
  3. Genomic approaches uncover increasing complexities in the regulatory landscape at the human SCL (TAL1) locus. (PMID: 20140202) Dhami P. … Vetrie D. (PLoS ONE 2010) 3 23
  4. Inhibition of the hTERT promoter by the proto-oncogenic protein TAL1. (PMID: 19587703) Terme J.M. … Jalinot P. (Leukemia 2009) 3 23
  5. Assembly of the oncogenic DNA-binding complex LMO2-Ldb1-TAL1-E12. (PMID: 17910069) Ryan D.P. … Matthews J.M. (Proteins 2008) 3 23

Products for TAL1 Gene

Sources for TAL1 Gene

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