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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAL1 Gene

protein-coding   GIFtS: 63
GCID: GC01M047681

T-cell acute lymphocytic leukemia 1


(Previous symbol: TCL5)
 Explore 27 diseases affiliated with
TAL1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TAL1    

Aliases
for TAL1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4

Aliases
T-Cell Acute Lymphocytic Leukemia 11 2     T-Cell Leukemia/Lymphoma Protein 52 3
SCL1 2 3 5     T-Cell Acute Lymphocytic Leukemia Protein 12
TCL51 2 3 5     Tal-11
BHLHa171     Tal-1 Product2
Class A Basic Helix-Loop-Helix Protein 172 3     BHLHA173
Stem Cell Protein2 3     TAL-13

External Ids:    HGNC: 115561   Entrez Gene: 68862   Ensembl: ENSG000001623677   OMIM: 1870405   UniProtKB: P175423   
ORGUL members:    fRNAdb10:FR048180 FR061800      
H-InvDB:HIT000215729 HIT000215730    
NCBI:S53678 S53686    
RNAdb:HIV1374 HIV1375    

Export aliases for TAL1 gene to outside databases

Previous GC identifers: GC01M047308 GC01M046571 GC01M047040 GC01M047051 GC01M047393 GC01M047454 GC01M045798


Summaries
for TAL1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: TAL1_HUMAN, P17542
Function: Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic
differentiation. Serves as a positive regulator of erythroid differentiation (By similarity)

Gene Wiki entry for TAL1

fRNAdb sequence ontology for TAL1:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for TAL1

Genomic Views
for TAL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_032977.9  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAL1 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TAL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TAL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32   Ensembl cytogenetic band:  1p33   HGNC cytogenetic band: 1p32

TAL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAL1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M047681:  view genomic region     (about GC identifiers)

Start:
 47,681,963 bp from pter      End:
 47,697,892 bp from pter
Size:
 15,930 bases      Orientation:
 minus strand

Proteins
for TAL1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TAL1_HUMAN, P17542 (See protein sequence)
Recommended Name: T-cell acute lymphocytic leukemia protein 1  
Size: 331 amino acids; 34271 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to
the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1
complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3 (By similarity)
Subcellular location: Nucleus (By similarity)
Secondary accessions: D3DQ24
Alternative splicing: 3 isoforms:  P17542-1   P17542-2   P17542-3   

Explore the universe of human proteins at neXtProt for TAL1: NX_P17542

Post-translational modifications:

  • Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia (By similarity)1
  • Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid
    • degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it
    could not be observed in large vessel endothelial cells (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P17542

    • TAL1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003180.1  
    ENSEMBL proteins: 
     ENSP00000360951   ENSP00000294339   ENSP00000360950  

    Human Recombinant Protein Products: 
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    Uscn Proteins for TAL1

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000118colocalizes with histone deacetylase complex IDA19497860
    GO:0000790nuclear chromatin IDA--
    GO:0005634nucleus IDA19497860
    GO:0005667transcription factor complex IDA15920471
    GO:0033193colocalizes with Lsd1/2 complex IDA19497860


    TAL1 for ontologies           About GeneDecksing



    TAL1 Antibody Products: 
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    ThermoFisher Antibodies for TAL1

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    Uscn ELISAs and CLIAs for TAL1

    Protein Domains /
    Families
    for TAL1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TAL1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR011598 HLH_dom

    Graphical View of Domain Structure for InterPro Entry P17542

    ProtoNet protein and cluster: P17542

    1 Blocks protein family: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: TAL1_HUMAN, P17542
    Domain: The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    Function
    for TAL1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TAL1_HUMAN, P17542
    Function: Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic
    differentiation. Serves as a positive regulator of erythroid differentiation (By similarity)

    miRNA
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    hsa-miR-3678-3p hsa-miR-549 hsa-miR-4254 hsa-miR-520e hsa-miR-106a hsa-miR-128 hsa-miR-938 hsa-miR-1260b
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    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TAL1 (see all 7)
    OriGene shRNA RFP: TAL1
    OriGene siRNA: TAL1
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for TAL1

    In Situ Assay
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    Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding ----
    GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding IEA--
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IEA--
    GO:0001085RNA polymerase II transcription factor binding IPI15920471
    GO:0003677DNA binding ----


    TAL1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for TAL1: Tal1tm1Sho Tal1tm1Wehi
         13 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Tal1):
     cardiovascular system  cellular  embryogenesis  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  nervous system 
     pigmentation  renal/urinary system  skeleton 

    TAL1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TAL1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TAL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/62 Interacting proteins for TAL1 (P175421, 2, 3 ENSP000002943394) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GATA3P237712, 3, ENSP000003686324MINT-8142126 I2D: score=3 STRING: ENSP00000368632
    TCF12Q990812, 3, ENSP000003310574MINT-8142126 I2D: score=3 STRING: ENSP00000331057
    TCF3P159231, 2, 3, ENSP000002629654EBI-1753878,EBI-769630 MINT-8142126 I2D: score=5 STRING: ENSP00000262965
    RUNX1Q011962, 3, ENSP000003003054MINT-8142169 MINT-8142126 I2D: score=2 STRING: ENSP00000300305
    ETS1P149212, 3, ENSP000003764364MINT-8142126 MINT-8142147 I2D: score=1 STRING: ENSP00000376436
    About this table

    Gene Ontology (GO): 5/33 biological process terms (GO ID links to tree view) (see all 33):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001525angiogenesis IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter ISS--
    GO:0006366transcription from RNA polymerase II promoter ----
    GO:0007626locomotory behavior IEA--


    TAL1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TAL1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TAL1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TAL1
    6 Novoseek chemical compound relationships for TAL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tal 2 88.9 10 1763056 (3), 8142619 (3), 7957052 (3), 14975618 (1)
    retinoic acid 7.55 13 15380350 (3), 19230972 (2), 9665825 (1), 9111367 (1)
    etoposide 5.68 1 16778171 (1)
    oligonucleotide 0 1 16621969 (1)
    serine 0 4 8895560 (2), 7970731 (1), 9111058 (1)
    vegf 0 1 15708566 (1)

    Search CenterWatch for drugs/clinical trials and news about TAL1 

    Transcripts
    for TAL1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    		 2 fRNAdb Secondary structures:


    REFSEQ mRNAs for TAL1 gene: 
    NM_003189.2  

    Unigene Cluster for TAL1:

    T-cell acute lymphocytic leukemia 1
    Hs.705618  [show with all ESTs]
    Unigene Representative Sequence: NM_003189
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371884(uc009vyq.2 uc001cqy.2 uc001cra.1 uc001cqz.1)
    ENST00000294339 ENST00000459729 ENST00000464796(uc001crb.1) ENST00000481091
    ENST00000465912 ENST00000371883(uc001cqx.2)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TAL1
    8/82 QIAGEN miScript miRNA Assays for microRNAs that regulate TAL1 (see all 82):
    hsa-miR-3678-3p hsa-miR-549 hsa-miR-4254 hsa-miR-520e hsa-miR-106a hsa-miR-128 hsa-miR-938 hsa-miR-1260b
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    Inhib. RNA
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    OriGene shRNA RFP: TAL1
    OriGene siRNA: TAL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAL1
    Clone
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    GenScript: all cDNA clones in your preferred vector: TAL1 (NM_003189)
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    Primer
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    Additional cDNA sequence: 

    BC144215.1 M29038.1 M61108.1 S53245.1 X51990.1 

    5 DOTS entries:

    DT.87016392  DT.87016391  DT.121402140  DT.100752475  DT.99999943 

    24/61 AceView cDNA sequences (see all 61):

    S53691 CR624822 S53678 S53686 AI333301 AI123881 AI076543 BV177080 
    BX449186 H43303 W04962 N76947 W01885 BU687269 BV199247 AA699603 
    S53245 AW300901 NM_003189 N71056 CB044957 BU678016 CK300042 AA252051 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TAL1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7
    SP1:              -                             -         
    SP2:                                            -         
    SP3:        -     -     -     -                 -         
    SP4:                                                      


    ECgene alternative splicing isoforms for TAL1

    Expression
    for TAL1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TAL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGTGATGAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TAL1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    9 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneBone MarrowHematopoietic Stem CellsBlood
    Extraembryonic MesodermExtraembryonic Blood IslandsExtraembryonic AngioblastsEndothelium
    Extraembryonic MesodermExtraembryonic Blood IslandsPrimitive Hematopoietic Stem CellsBlood
    Lateral Plate MesodermAorta-Gonad-MesonephrosHematopoietic Stem CellsBlood
    Lateral Plate MesodermEmbryonic Blood IslandsAngioblastsEndothelium
    LiverLiver BudHematopoietic Stem CellsBlood
    Primitive StreakPosterior Primitive StreakHemangioblastsBlood, Endothelium
    Yolk SacDefinitive Yolk SacDefinitive Hematopoietic Stem CellsBlood
    HeartCardiac CrescentCardiac Crescent CellsMyocardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 7 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    HSF-1 (UC01) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Embryoid bodies (Generation and expan...)
    CD31, CD144 positive cells (Two-step protocol fo...)

    See TAL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TAL1

    SOURCE GeneReport for Unigene cluster: Hs.705618

    UniProtKB/Swiss-Prot: TAL1_HUMAN, P17542
    Tissue specificity: Leukemic stem cell

        SABiosciences Expression via Pathway-Focused PCR Arrays including TAL1: 
              Leukemia in human mouse rat
              Hematopoiesis in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for TAL1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TAL1 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TAL11 T-cell acute lymphocytic leukemia 1 72.34(n)
    70.92(a)    		   396298  NM_205352.1  NP_990683.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TAL16
    		 --
    		 79(a)
    		 1 ↔ 1
    		 GL343249.1(1715738-1730093)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3980282 stem cell leukemia protein SCL 75.87(n)    AF060151.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii tal12 T-cell acute lymphocytic leukemia 1 77.3(n)   30766  AF045432.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta HLH3B6
    		 Helix loop helix protein 3B
    		 18(a)
    		 1 → many
    		 X(2574232-2575756)


    ENSEMBL Gene Tree for TAL1 (if available)
    TreeFam Gene Tree for TAL1 (if available) 

    Paralogs
    for TAL1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TAL1 gene
    TCF242  NHLH12  TWIST12  TWIST22  HAND22  TCF232  LYL12  NHLH22  
    TAL22  TCF152  SCXB2  TCF212  HAND12  MSC2  SCXA2  
    4 SIMAP similar genes for TAL1 using alignment to 3 protein entries:     TAL1_HUMAN (see all proteins):
    tal-1    SCL    TAL2    NHLH1

    TAL1 for paralogs           About GeneDecksing



    Genomic Variants
    for TAL1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/262 NCBI SNPs in TAL1 are shown (see all 262)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs781324471,2
    		F,--47681523(+) CCCCAA/GTCCTT 1 -- int11Minor allele frequency- G:0.04EA 120
    rs27983551,2
    		C,F,--47681726(-) CCCCTC/TGGCTT 1 -- int115Minor allele frequency- N:0.00EA NA WA CSA 588
    rs66958981,2
    		C,F,--47681761(+) GGAGAG/AAAAGA 1 -- int17Minor allele frequency- A:0.32NA WA 248
    rs27587421,2
    		C,F,--47681779(-) CCTCCA/CCAGGG 1 -- int115Minor allele frequency- C:0.26EA NA WA CSA 1896
    rs1909081491,2
    		--47681798(+) CTCCTC/TCCCAC 1 -- int10--------
    rs758474141,2
    		F,--47681851(+) GACTAC/TAGCTG 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1834792231,2
    		--47681902(+) CCATGA/GCTTTT 1 -- int10--------
    rs1405298591,2
    		--47681997(+) TTCCCA/GATACA 1 -- ut310--------
    rs76641,2
    		C,F,A,H,--47682017(-) TGTGTA/CTATAT 1 -- ut31 ese327Minor allele frequency- C:0.25MN EA NA NS CSA WA 4420
    rs1876925591,2
    		--47682019(+) ATATAC/GACATC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TAL1 (47681963 - 47697892 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TAL1: --
    Human Gene Mutation Database (HGMD): TAL1

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for TAL1

    Disorders / Diseases
    for TAL1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TAL1 for disorders           About GeneDecksing

    OMIM gene information: 187040 115665 116600 121800 155600 211420 600975 605225 605606 606788 606852 606928 607317 607671 608446 608543 608553 608995    
    UniProtKB/Swiss-Prot: TAL1_HUMAN, P17542
  • Note=A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias
    • (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes

    20/27 diseases for TAL1 (see all 27):    About MalaCards
    acute lymphocytic leukemia    leukemia/lymphoma    lymphocytic leukemia    leukemia
    leukemia-1, t-cell acute lymphocytic    b-cell non-hodgkin lymphoma    t-cell leukemia    diamond-blackfan anemia
    human t-cell leukemia virus type 1    non-hodgkin lymphoma    acute lymphoblastic leukemia    acute lymphoblastic leukemia, childhood
    lymphoblastic leukemia    stem cell leukemia    hodgkin's lymphoma    myeloid leukemia
    acute myeloid leukemia    acute leukemia    lymphoblastic lymphoma    protein s deficiency

    1 disease from the University of Copenhagen DISEASES database for TAL1:
    Leukemia

    10/19 Novoseek disease relationships for TAL1 gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    t-all 95.2 188 9695959 (7), 8208530 (6), 7605997 (5), 9020185 (5) (see all 68)
    t-cell childhood acute lymphoblastic leukemia 82.4 4 9597892 (1), 9950206 (1), 8471769 (1), 8321044 (1)
    leukemia t-cell 73.9 18 16778171 (2), 10625632 (2), 1382561 (1), 9931488 (1) (see all 13)
    leukemogenesis 70.5 9 8437851 (1), 8289805 (1), 7774592 (1), 9020185 (1) (see all 7)
    erythroleukemia 68.3 12 10688671 (2), 1453013 (1), 8943307 (1), 9699481 (1) (see all 6)
    minimal residual disease 66.9 6 10049045 (2), 9950206 (1), 11243385 (1), 11839375 (1)
    leukemia 61.4 27 2040693 (2), 8778337 (2), 7824274 (2), 15917481 (1) (see all 20)
    acute leukemia 58.7 11 10049045 (2), 1311214 (1), 15917481 (1), 8142619 (1) (see all 8)
    leukaemia lymphocytic 55.2 5 19571616 (1), 2000219 (1), 11839375 (1), 8547631 (1) (see all 5)
    lymphoma lymphoblastic 45 4 9116269 (1), 9171354 (1)

    Genatlas disease: TAL1
    acute lymphoblastic leukemia (T cell) with interstitial deletion 5' to TAL1 (stem-cell leukemia) or with
    translocations t(1;14)(p32;q11),t(1;7)(p32;p35),t(1;3)(p34;p21),t(1;5)(p32;q31),see SCL,SIL,TCTA

    Human Genome Epidemiology (HuGE) Navigator: TAL1 (6 documents)
    Tumor Gene Database (TGDB): TAL1

    Export disorders for TAL1 gene to outside databases

    Publications
    for TAL1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TAL1 gene, integrated from 9 sources (see all 221):
    (articles sorted by number of sources associating them with TAL1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The SCL gene product: a positive regulator of erythroid differentiation. (PubMed id 1396592)1, 2, 9 Aplan P.D.... Kirsch I.R. (1992)
    2. Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia. (PubMed id 2230650)1, 2, 9 Chen Q.... Baer R. (1990)
    3. Products of the TAL1 oncogene: basic helix-loop-helix proteins phosphorylated at serine residues. (PubMed id 8437851)1, 2, 9 Cheng J.-T.... Baer R. (1993)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. The SCL gene is formed from a transcriptionally complex locus. (PubMed id 2247063)1, 2 Aplan P.D.... Kirsch I.R. (1990)
    6. The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein. (PubMed id 2303035)1, 2 Chen Q.... Baer R. (1990)
    7. The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif. (PubMed id 2602361)1, 2 Begley C.G....Kirsch I.R. (1989)
    8. Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma. (PubMed id 2740341)1, 3 Finger L.R....Croce C.M. (1989)
    9. An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice. (PubMed id 9171354)1, 9 Aplan P.D....Gross K.W. (1997)
    10. mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor. (PubMed id 10688671)1, 9 Huang S. and Brandt S.J. (2000)

    External Searches for TAL1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing TAL1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6886 HGNC: 11556 AceView: TAL1 Ensembl:ENSG00000162367 euGenes: HUgn6886
    ECgene: TAL1 H-InvDB: TAL1

    Other Databases showing TAL1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TAL1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TAL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TAL1 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TAL1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TAL1 gene:
    Search GeneIP for patents involving TAL1

    GeneCards and IP:
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    About This Section

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