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Aliases for TAL1 Gene

Aliases for TAL1 Gene

  • TAL BHLH Transcription Factor 1, Erythroid Differentiation Factor 2 3 5
  • Class A Basic Helix-Loop-Helix Protein 17 3 4
  • T-Cell Acute Lymphocytic Leukemia 1 2 3
  • T-Cell Leukemia/Lymphoma Protein 5 3 4
  • Stem Cell Protein 3 4
  • BHLHa17 3 4
  • Tal-1 3 4
  • TCL5 3 4
  • SCL 3 4
  • T-Cell Acute Lymphocytic Leukemia Protein 1 3
  • Tal-1 Product 3

External Ids for TAL1 Gene

Previous HGNC Symbols for TAL1 Gene

  • TCL5

Previous GeneCards Identifiers for TAL1 Gene

  • GC01M047308
  • GC01M046571
  • GC01M047040
  • GC01M047051
  • GC01M047393
  • GC01M047454
  • GC01M047681
  • GC01M045798

Summaries for TAL1 Gene

GeneCards Summary for TAL1 Gene

TAL1 (TAL BHLH Transcription Factor 1, Erythroid Differentiation Factor) is a Protein Coding gene. Diseases associated with TAL1 include Leukemia, Acute Lymphoblastic and Precursor T-Cell Acute Lymphoblastic Leukemia. Among its related pathways are MAPK-Erk Pathway and NF-kappaB Signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is LYL1.

UniProtKB/Swiss-Prot for TAL1 Gene

  • Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).

Gene Wiki entry for TAL1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAL1 Gene

Genomics for TAL1 Gene

Regulatory Elements for TAL1 Gene

Enhancers for TAL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F047178 1.2 ENCODE 16.2 +51.5 51511 4.5 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 YBX1 ZNF143 FOS EFCAB14-AS1 PDZK1IP1 TAL1 ENSG00000226252 CYP4B1 LINC00853 CYP4A22 CYP4A22-AS1
GH01F047188 1.3 Ensembl ENCODE 12.9 +41.1 41139 4.5 HDGF PKNOX1 MLX ARID4B DMAP1 ZNF48 ZNF2 ZNF143 ZNF263 SP5 PDZK1IP1 ENSG00000226252 TAL1 FOXE3 LINC01389 FOXD2 FOXD2-AS1 GC01M047220
GH01F047332 1.4 FANTOM5 ENCODE 11.5 -101.9 -101916 4.2 HDGF ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 SP3 SP5 ENSG00000226252 FOXE3 EFCAB14-AS1 CMPK1 SKINT1L TRABD2B TAL1 LOC105378702 ENSG00000272491 LINC01389
GH01F047224 1 FANTOM5 13.6 +7.4 7383 0.2 INSM2 KLF17 FEZF1 ZNF2 ZEB1 ZNF121 GLIS2 ZNF366 GATA2 SCRT2 TAL1 PDZK1IP1 ENSG00000226252 GC01M047220
GH01F047211 1.5 FANTOM5 Ensembl ENCODE 6.6 +19.7 19700 2.7 HDGF NFXL1 ZBTB40 GATA2 SCRT2 CREM SMARCA5 ZNF263 ZBTB2 ZEB2 PDZK1IP1 TAL1 CMPK1 GC01M047220
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAL1 on UCSC Golden Path with GeneCards custom track

Promoters for TAL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000282273 1873 3801 HDGF ARNT CREB3L1 SIN3A YY1 FOS KLF13 JUNB REST SMARCB1

Genomic Location for TAL1 Gene

Chromosome:
1
Start:
47,216,290 bp from pter
End:
47,232,373 bp from pter
Size:
16,084 bases
Orientation:
Minus strand

Genomic View for TAL1 Gene

Genes around TAL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAL1 Gene

Proteins for TAL1 Gene

  • Protein details for TAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17542-TAL1_HUMAN
    Recommended name:
    T-cell acute lymphocytic leukemia protein 1
    Protein Accession:
    P17542
    Secondary Accessions:
    • D3DQ24

    Protein attributes for TAL1 Gene

    Size:
    331 amino acids
    Molecular mass:
    34271 Da
    Quaternary structure:
    • Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3. Interacts with SBNO2; this interaction inhibits TAL1 occupancy of the DCSTAMP promoter, leading to the activation of the DCSTAMP promoter by the transcription factor MITF.

    Three dimensional structures from OCA and Proteopedia for TAL1 Gene

    Alternative splice isoforms for TAL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAL1 Gene

Post-translational modifications for TAL1 Gene

  • Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia (By similarity).
  • Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells (By similarity).
  • Ubiquitination at Lys 185, Lys 234, and Lys 241
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TAL1 Gene

Domains & Families for TAL1 Gene

Gene Families for TAL1 Gene

Protein Domains for TAL1 Gene

Suggested Antigen Peptide Sequences for TAL1 Gene

Graphical View of Domain Structure for InterPro Entry

P17542

UniProtKB/Swiss-Prot:

TAL1_HUMAN :
  • The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.
Domain:
  • The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.
  • Contains 1 bHLH (basic helix-loop-helix) domain.
genes like me logo Genes that share domains with TAL1: view

Function for TAL1 Gene

Molecular function for TAL1 Gene

UniProtKB/Swiss-Prot Function:
Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).

Gene Ontology (GO) - Molecular Function for TAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IEA --
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA --
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with TAL1: view
genes like me logo Genes that share phenotypes with TAL1: view

Human Phenotype Ontology for TAL1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TAL1 Gene

MGI Knock Outs for TAL1:

Animal Model Products

Transcription Factor Targets for TAL1 Gene

Selected GeneGlobe predicted Target genes for TAL1
Targeted motifs for TAL1 Gene
HOMER Transcription Factor Regulatory Elements motif TAL1
  • Consensus sequence: ANCAGCTG Submotif: canonical Cell Type: HPC7 GEO ID: GSE13511

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) for TAL1 Gene

Localization for TAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAL1 gene
Compartment Confidence
nucleus 5
plasma membrane 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 colocalizes_with histone deacetylase complex IDA 19497860
GO:0000790 nuclear chromatin IDA 20855495
GO:0005634 nucleus IEA,IDA 19497860
GO:0005667 transcription factor complex IEA,IDA 15920471
GO:0033193 colocalizes_with Lsd1/2 complex IDA 19497860
genes like me logo Genes that share ontologies with TAL1: view

Pathways & Interactions for TAL1 Gene

genes like me logo Genes that share pathways with TAL1: view

Pathways by source for TAL1 Gene

1 Sino Biological pathway for TAL1 Gene
1 Cell Signaling Technology pathway for TAL1 Gene

SIGNOR curated interactions for TAL1 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001525 angiogenesis IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter ISS --
genes like me logo Genes that share ontologies with TAL1: view

Drugs & Compounds for TAL1 Gene

(2) Drugs for TAL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for TAL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TAL1: view

Transcripts for TAL1 Gene

Unigene Clusters for TAL1 Gene

T-cell acute lymphocytic leukemia 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAL1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: - -
SP2: -
SP3: - - - - -
SP4:

Relevant External Links for TAL1 Gene

GeneLoc Exon Structure for
TAL1
ECgene alternative splicing isoforms for
TAL1

Expression for TAL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TAL1 Gene

This gene is overexpressed in Whole Blood (x4.6).

Protein differential expression in normal tissues from HIPED for TAL1 Gene

This gene is overexpressed in Liver (62.4) and Fetal Liver (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TAL1 Gene



Protein tissue co-expression partners for TAL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TAL1 Gene:

TAL1

SOURCE GeneReport for Unigene cluster for TAL1 Gene:

Hs.705618

mRNA Expression by UniProt/SwissProt for TAL1 Gene:

P17542-TAL1_HUMAN
Tissue specificity: Leukemic stem cell.
genes like me logo Genes that share expression patterns with TAL1: view

Primer Products

Orthologs for TAL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TAL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAL1 34 35
  • 99.9 (n)
cow
(Bos Taurus)
Mammalia TAL1 34 35
  • 90.52 (n)
dog
(Canis familiaris)
Mammalia TAL1 34 35
  • 90.42 (n)
mouse
(Mus musculus)
Mammalia Tal1 34 16 35
  • 88.75 (n)
rat
(Rattus norvegicus)
Mammalia Tal1 34
  • 88.05 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TAL1 35
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAL1 35
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCL 35
  • 82 (a)
OneToOne
TAL1 34
  • 72.46 (n)
lizard
(Anolis carolinensis)
Reptilia TAL1 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tal1 34
  • 68.45 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398028 34
zebrafish
(Danio rerio)
Actinopterygii tal1 34 35
  • 68.73 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12172 34
fruit fly
(Drosophila melanogaster)
Insecta HLH3B 35
  • 19 (a)
OneToMany
Species where no ortholog for TAL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAL1 Gene

ENSEMBL:
Gene Tree for TAL1 (if available)
TreeFam:
Gene Tree for TAL1 (if available)

Paralogs for TAL1 Gene

Paralogs for TAL1 Gene

(4) SIMAP similar genes for TAL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TAL1: view

Variants for TAL1 Gene

Sequence variations from dbSNP and Humsavar for TAL1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1010812 -- 47,218,494(-) CTGGG(A/G)GGTTG utr-variant-3-prime
rs1049075 -- 47,216,631(-) CAACT(A/C)TTTCG utr-variant-3-prime
rs111472404 -- 47,230,773(+) GCATT(-/AGCAA)TTACA intron-variant, utr-variant-5-prime
rs112017348 -- 47,217,387(+) GTCTC(A/T)CACAC utr-variant-3-prime
rs11211480 -- 47,227,548(+) ACTAG(A/G)CACCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAL1 Gene

Variant ID Type Subtype PubMed ID
nsv475889 CNV novel sequence insertion 20440878
nsv475925 CNV novel sequence insertion 20440878

Variation tolerance for TAL1 Gene

Residual Variation Intolerance Score: 64.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.46; 43.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAL1 Gene

Human Gene Mutation Database (HGMD)
TAL1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAL1 Gene

Disorders for TAL1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for TAL1 Gene - From: OMIM, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
leukemia, acute lymphoblastic
  • leukemia, t-cell acute lymphocytic, somatic
precursor t-cell acute lymphoblastic leukemia
  • t-all
t-cell acute lymphocytic leukemia-1
  • leukemia-1, t-cell acute lymphocytic
acute lymphocytic leukemia
  • acute lymphoblastic leukemia
leukemia
- elite association - COSMIC cancer census association via MalaCards
Search TAL1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TAL1_HUMAN
  • Note=A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes. {ECO:0000269 PubMed:2303035}.

Genatlas disease for TAL1 Gene

acute lymphoblastic leukemia (T cell) with interstitial deletion 5 to TAL1 (stem-cell leukemia) or with translocations t(1;14)(p32;q11),t(1;7)(p32;p35),t(1;3)(p34;p21),t(1;5)(p32;q31),see SCL,SIL,TCTA

Relevant External Links for TAL1

Genetic Association Database (GAD)
TAL1
Human Genome Epidemiology (HuGE) Navigator
TAL1
Tumor Gene Database (TGDB):
TAL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAL1
genes like me logo Genes that share disorders with TAL1: view

Publications for TAL1 Gene

  1. Products of the TAL1 oncogene: basic helix-loop-helix proteins phosphorylated at serine residues. (PMID: 8437851) Cheng J.-T. … Baer R. (Oncogene 1993) 3 4 22 64
  2. The SCL gene product: a positive regulator of erythroid differentiation. (PMID: 1396592) Aplan P.D. … Kirsch I.R. (EMBO J. 1992) 3 4 22 64
  3. Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia. (PMID: 2230650) Chen Q. … Baer R. (J. Exp. Med. 1990) 3 4 22 64
  4. Genomic approaches uncover increasing complexities in the regulatory landscape at the human SCL (TAL1) locus. (PMID: 20140202) Dhami P. … Vetrie D. (PLoS ONE 2010) 3 22 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for TAL1 Gene

Sources for TAL1 Gene

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