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TAL1 Gene

protein-coding   GIFtS: 61
GCID: GC01M047681

T-Cell Acute Lymphocytic Leukemia 1


(Previous symbol: TCL5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 4

Aliases
T-Cell Acute Lymphocytic Leukemia 11 2     T-Cell Leukemia/Lymphoma Protein 52 3
TCL51 2 3 5     T-Cell Acute Lymphocytic Leukemia Protein 12
SCL2 3 5     tal-12
Class A Basic Helix-Loop-Helix Protein 172 3     Tal-1 Product2
Stem Cell Protein2 3     BHLHA173
bHLHa172 3     TAL-13

External Ids:    HGNC: 115561   Entrez Gene: 68862   Ensembl: ENSG000001623677   OMIM: 1870405   UniProtKB: P175423   
ORGUL members:    fRNAdb10:FR061800 FR048180 FR139838 FR005385      
H-InvDB12:HIT000215730 HIT000215729 HIT000343060 HIT000215731    
NCBI13:S53686 S53678 DQ358744 S53691    
RNAdb15:HIV1375 HIV1374 HIV1376    

Export aliases for TAL1 gene to outside databases

Previous GC identifers: GC01M047308 GC01M046571 GC01M047040 GC01M047051 GC01M047393 GC01M047454 GC01M045798


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TAL1 Gene:
TAL1 (T-cell acute lymphocytic leukemia 1) is a protein-coding gene. Diseases associated with TAL1 include t-cell leukemia, and cd3epsilon deficiency. GO annotations related to this gene include chromatin binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is NHLH1.

UniProtKB/Swiss-Prot: TAL1_HUMAN, P17542
Function: Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic
differentiation. Serves as a positive regulator of erythroid differentiation (By similarity)

Gene Wiki entry for TAL1 Gene

fRNAdb sequence ontology for TAL1:
ncRNA - An RNA transcript that does not encode for a protein rather the RNA molecule is the gene product.

View fRNAdb secondary structures for TAL1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TAL1 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAL1 promoter sequence
   Search Chromatin IP Primers for TAL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p32   Ensembl cytogenetic band:  1p33   HGNC cytogenetic band: 1p32

TAL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAL1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M047681:  view genomic region     (about GC identifiers)

Start:
47,681,962 bp from pter      End:
47,697,892 bp from pter
Size:
15,931 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for TAL1

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TAL1_HUMAN, P17542 (See protein sequence)
Recommended Name: T-cell acute lymphocytic leukemia protein 1  
Size: 331 amino acids; 34271 Da
Subunit: Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3.
Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2.
Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3 (By similarity)
2 PDB 3D structures from and Proteopedia for TAL1:
2YPA (3D)        2YPB (3D)    
Secondary accessions: D3DQ24
Alternative splicing: 3 isoforms:  P17542-1   P17542-2   P17542-3   

Explore the universe of human proteins at neXtProt for TAL1: NX_P17542

Explore proteomics data for TAL1 at MOPED

Post-translational modifications: 

  • Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia (By similarity)1
  • Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for
    rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial
    cells, since it could not be observed in large vessel endothelial cells (By similarity)1
  • Ubiquitination2 at Lys185, Lys234, Lys241
  • Modification sites at PhosphoSitePlus

  • See TAL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001274276.1  NP_001277332.1  NP_001277333.1  NP_001277334.1  NP_001277335.1  NP_003180.1  

    ENSEMBL proteins: 
     ENSP00000360951   ENSP00000294339   ENSP00000360950  

    TAL1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for TAL1
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    Novus Biologicals TAL1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TAL1

    TAL1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TAL1
    R&D Systems Antibodies for TAL1 (SCL/Tal1)
    Cell Signaling Technology (CST) Antibodies for TAL1 
    OriGene Antibodies for TAL1
    OriGene Custom Antibody Services for TAL1
    Novus Biologicals TAL1 Antibodies
    Search for Antibodies for TAL1 at Abcam
    Cloud-Clone Corp. Antibodies for TAL1
    ThermoFisher Antibodies for TAL1
    LSBio Antibodies in human, mouse, rat for TAL1

    TAL1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for TAL1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TAL1
    Cloud-Clone Corp. CLIAs for TAL1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bHLH: Basic helix-loop-helix proteins

    1 InterPro protein domain:
     IPR011598 bHLH_dom

    Graphical View of Domain Structure for InterPro Entry P17542

    ProtoNet protein and cluster: P17542

    1 Blocks protein domain: IPB001092 Basic helix-loop-helix dimerization domain bHLH

    UniProtKB/Swiss-Prot: TAL1_HUMAN, P17542
    Domain: The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1
    Similarity: Contains 1 bHLH (basic helix-loop-helix) domain


    TAL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAL1_HUMAN, P17542
    Function: Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic
    differentiation. Serves as a positive regulator of erythroid differentiation (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding ----
    GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding IEA--
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IEA--
    GO:0001085RNA polymerase II transcription factor binding IPI15920471
    GO:0003677DNA binding ----
         
    TAL1 for ontologies           About GeneDecksing


    Phenotypes:
         13 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Tal1):
     cardiovascular system  cellular  embryogenesis  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  mortality/aging  nervous system 
     pigmentation  renal/urinary system  skeleton 

    TAL1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TAL1: Tal1tm1Sho Tal1tm1Wehi

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TAL1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TAL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TAL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TAL1

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for TAL1 (see all 546):
    ABCA7,  ADAM8,  ADAT3,  ADCY2,  ADO,  AGAP1,  AGBL2,  AGFG2,  AIM1,  ANKRD40

    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  ANCAGCTG 

    miRNA
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    Block miRNA regulation of human, mouse, rat TAL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TAL1 (see all 82):
    hsa-miR-3678-3p hsa-miR-549 hsa-miR-4254 hsa-miR-520e hsa-miR-106a hsa-miR-128 hsa-miR-938 hsa-miR-1260b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TAL1
    Predesigned siRNA for gene silencing in human, mouse, rat TAL1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TAL1

    Clone
    Products:
         
    OriGene clones in human, mouse for TAL1 (see all 6)
    OriGene ORF clones in mouse, rat for TAL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TAL1 (NM_003189)
    Sino Biological Human cDNA Clone for TAL1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAL1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TAL1
    Browse ESI BIO Cell Lines and PureStem Progenitors for TAL1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TAL1_HUMAN, P17542: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000118colocalizes with histone deacetylase complex IDA19497860
    GO:0000790nuclear chromatin IDA--
    GO:0005634nucleus IDA19497860
    GO:0005667transcription factor complex IDA15920471
    GO:0033193colocalizes with Lsd1/2 complex IDA19497860

    TAL1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TAL1 About    
    See pathways by source

    SuperPathContained pathways About
    1Lymphocyte Signaling
    Lymphocyte Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for TAL1
        Lymphocyte Signaling




    TAL1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TAL1: 
              Leukemia in human mouse rat
              Hematopoiesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TAL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TAL1 (P175421, 2, 3 ENSP000002943394) via UniProtKB, MINT, STRING, and/or I2D (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GATA3P237712, 3, ENSP000003686324MINT-8142126 I2D: score=3 STRING: ENSP00000368632
    TCF12Q990812, 3, ENSP000003310574MINT-8142126 I2D: score=3 STRING: ENSP00000331057
    ENSG00000215641P143733I2D: score=2 
    ENSG00000229006P143733I2D: score=2 
    ENSG00000234495P143733I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 33):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001525angiogenesis IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter ISS--
    GO:0006366transcription from RNA polymerase II promoter ----
    GO:0007626locomotory behavior IEA--

    TAL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TAL1

    6 Novoseek inferred chemical compound relationships for TAL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tal 2 88.9 10 1763056 (3), 8142619 (3), 7957052 (3), 14975618 (1)
    retinoic acid 7.55 13 15380350 (3), 19230972 (2), 9665825 (1), 9111367 (1)
    etoposide 5.68 1 16778171 (1)
    oligonucleotide 0 1 16621969 (1)
    serine 0 4 8895560 (2), 7970731 (1), 9111058 (1)
    vegf 0 1 15708566 (1)



    TAL1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    4 fRNAdb Secondary structures:


    REFSEQ mRNAs for TAL1 gene (6 alternative transcripts): 
    NM_001287347.2  NM_001290403.1  NM_001290404.1  NM_001290405.1  NM_001290406.1  NM_003189.5  

    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371884(uc009vyq.2 uc001cqy.2 uc001cra.1 uc001cqz.1)
    ENST00000294339 ENST00000459729 ENST00000464796(uc001crb.1) ENST00000481091
    ENST00000465912 ENST00000371883(uc001cqx.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat TAL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TAL1 (see all 82):
    hsa-miR-3678-3p hsa-miR-549 hsa-miR-4254 hsa-miR-520e hsa-miR-106a hsa-miR-128 hsa-miR-938 hsa-miR-1260b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TAL1
    Clone
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    OriGene clones in human, mouse for TAL1 (see all 6)
    OriGene ORF clones in mouse, rat for TAL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TAL1 (NM_003189)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAL1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TAL1
    OriGene qSTAR qPCR primer pairs in human, mouse for TAL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TAL1
      QuantiTect SYBR Green Assays in human, mouse, rat TAL1
      QuantiFast Probe-based Assays in human, mouse, rat TAL1

    Selected AceView cDNA sequences (see all 61):

    CR624822 S53678 S53691 S53686 W04962 NM_003189 CB044957 H43303 
    AW300901 BV177080 AA252051 BU687269 AI333301 CK300042 W01051 N76947 
    M61108 BV199247 BX449186 AA699603 AI123881 AI076543 S53245 N71056 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TAL1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7
    SP1:              -                             -         
    SP2:                                            -         
    SP3:        -     -     -     -                 -         
    SP4:                                                      


    ECgene alternative splicing isoforms for TAL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TAL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGTGATGAT
    TAL1 Expression
    About this image


    TAL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 9 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             Peripheral blood-derived hematopoietic stem cells (family)
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Angioblasts Embryonic Blood Islands
     
     Extraembryonic Mesoderm (Extraembryonic Tissues)    fully expand to see all 2 entries
             Extraembryonic Angioblasts Extraembryonic Blood Islands
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Angioblasts Embryonic Blood Islands
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Liver Bud
    TAL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TAL1 Protein Expression

    UniProtKB/Swiss-Prot: TAL1_HUMAN, P17542
    Tissue specificity: Leukemic stem cell

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TAL1: 
              Leukemia in human mouse rat
              Hematopoiesis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TAL1
    OriGene qSTAR qPCR primer pairs in human, mouse for TAL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TAL1
    QuantiTect SYBR Green Assays in human, mouse, rat TAL1
    QuantiFast Probe-based Assays in human, mouse, rat TAL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TAL1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tal11 , 5 T cell acute lymphocytic leukemia 11, 5 88.75(n)1
    93.31(a)1
      4 (52.73 cM)5
    213491  NM_011527.21  NP_035657.11 
     1150564265 
    chicken
    (Gallus gallus)
    Aves TAL11 T-cell acute lymphocytic leukemia 1 72.46(n)
    70.57(a)
      396298  NM_205352.1  NP_990683.1 
    lizard
    (Anolis carolinensis)
    Reptilia TAL16
    T-cell acute lymphocytic leukemia 1
    79(a)
    1 ↔ 1
    GL343249.1(1715052-1730096)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3980282 stem cell leukemia protein SCL 75.87(n)    AF060151.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tal12 T-cell acute lymphocytic leukemia 1 77.3(n)   30766  AF045432.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta HLH3B6
    Helix loop helix protein 3B
    19(a)
    1 → many
    X(2574232-2575756)


    ENSEMBL Gene Tree for TAL1 (if available)
    TreeFam Gene Tree for TAL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TAL1 gene
    NHLH12  TWIST12  TWIST22  HAND22  NHLH22  LYL12  TAL22  TCF152  
    SCXB2  HAND12  SCXA2  
    4 SIMAP similar genes for TAL1 using alignment to 3 protein entries:     TAL1_HUMAN (see all proteins):
    tal-1    SCL    TAL2    NHLH1

    TAL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TAL1 (see all 316)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs781324471,2
    C,F--47681523(+) CCCCAA/GTCCTT 1 -- int11Minor allele frequency- G:0.04EA 120
    rs27983551,2
    C,F--47681726(-) CCCCTC/TGGCTT 1 -- int115Minor allele frequency- N:0.00EA NA WA CSA 588
    rs66958981,2
    C,F--47681761(+) GGAGAG/AAAAGA 1 -- int17Minor allele frequency- A:0.32NA WA 248
    rs27587421,2
    C,F--47681779(-) CCTCCA/CCAGGG 1 -- int115Minor allele frequency- C:0.26EA NA WA CSA 1896
    rs1909081491,2
    --47681798(+) CTCCTC/TCCCAC 1 -- int10--------
    rs758474141,2
    F--47681851(+) GACTAC/TAGCTG 1 -- int11Minor allele frequency- T:0.03WA 118
    rs1834792231,2
    --47681902(+) CCATGA/GCTTTT 1 -- int10--------
    rs1405298591,2
    C--47681997(+) TTCCCA/GATACA 1 -- ut310--------
    rs76641,2
    C,F,A,H--47682017(-) TGTGTA/CTATAT 1 -- ut31 ese327Minor allele frequency- C:0.25MN EA NA NS CSA WA 4420
    rs1876925591,2
    --47682019(+) ATATAC/GACATC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TAL1 (47681962 - 47697892 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TAL1: --
    Human Gene Mutation Database (HGMD): TAL1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TAL1
    DNA2.0 Custom Variant and Variant Library Synthesis for TAL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 187040OMIM information: 115665 116600 121800 155600 211420 600975 605225 605606 606788 606852 606928 607317 607671 608446 608543 608553 608995 181590    
    UniProtKB/Swiss-Prot: TAL1_HUMAN, P17542
  • Note=A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias
    (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes

  • Selected diseases for TAL1 (see all 30):    
    About MalaCards
    t-cell leukemia    cd3epsilon deficiency    leukemia-1, t-cell acute lymphocytic    acute lymphoblastic leukemia, childhood
    lymphoblastic lymphoma    precursor t-cell acute lymphoblastic leukemia    acute lymphocytic leukemia    acute leukemia
    lymphoblastic leukemia    diamond-blackfan anemia    leukemia    erythrocytosis
    human t-cell leukemia virus type 1    protein s deficiency    non-hodgkin lymphoma    hodgkin's lymphoma
    acute myeloid leukemia    anaplastic large cell lymphoma    myeloid leukemia    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for TAL1:
    Leukemia

    TAL1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for TAL1 gene (see all 19)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    t-all 95.2 188 9695959 (7), 8208530 (6), 7605997 (5), 9020185 (5) (see all 68)
    t-cell childhood acute lymphoblastic leukemia 82.4 4 9597892 (1), 9950206 (1), 8471769 (1), 8321044 (1)
    leukemia t-cell 73.9 18 16778171 (2), 10625632 (2), 1382561 (1), 9931488 (1) (see all 13)
    leukemogenesis 70.5 9 8437851 (1), 8289805 (1), 7774592 (1), 9020185 (1) (see all 7)
    erythroleukemia 68.3 12 10688671 (2), 1453013 (1), 8943307 (1), 9699481 (1) (see all 6)
    minimal residual disease 66.9 6 10049045 (2), 9950206 (1), 11243385 (1), 11839375 (1)
    leukemia 61.4 27 2040693 (2), 8778337 (2), 7824274 (2), 15917481 (1) (see all 20)
    acute leukemia 58.7 11 10049045 (2), 1311214 (1), 15917481 (1), 8142619 (1) (see all 8)
    leukaemia lymphocytic 55.2 5 19571616 (1), 2000219 (1), 11839375 (1), 8547631 (1) (see all 5)
    lymphoma lymphoblastic 45 4 9116269 (1), 9171354 (1)

    Genatlas disease: TAL1
    acute lymphoblastic leukemia (T cell) with interstitial deletion 5' to TAL1 (stem-cell leukemia) or with
    translocations t(1;14)(p32;q11),t(1;7)(p32;p35),t(1;3)(p34;p21),t(1;5)(p32;q31),see SCL,SIL,TCTA

    Genetic Association Database (GAD): TAL1
    Human Genome Epidemiology (HuGE) Navigator: TAL1 (6 documents)
    Tumor Gene Database (TGDB): TAL1

    Export disorders for TAL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TAL1 gene, integrated from 10 sources (see all 230):
    (articles sorted by number of sources associating them with TAL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The SCL gene product: a positive regulator of erythroid differentiation. (PubMed id 1396592)1, 2, 9 Aplan P.D.... Kirsch I.R. (EMBO J. 1992)
    2. Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia. (PubMed id 2230650)1, 2, 9 Chen Q.... Baer R. (J. Exp. Med. 1990)
    3. Products of the TAL1 oncogene: basic helix-loop-helix proteins phosphorylated at serine residues. (PubMed id 8437851)1, 2, 9 Cheng J.-T.... Baer R. (Oncogene 1993)
    4. Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias. (PubMed id 19865112)1, 4 Carbuccia N....Mozziconacci M.J. (Leukemia 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. The SCL gene is formed from a transcriptionally complex locus. (PubMed id 2247063)1, 2 Aplan P.D.... Kirsch I.R. (Mol. Cell. Biol. 1990)
    8. The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein. (PubMed id 2303035)1, 2 Chen Q.... Baer R. (EMBO J. 1990)
    9. The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motif. (PubMed id 2602361)1, 2 Begley C.G....Kirsch I.R. (Proc. Natl. Acad. Sci. U.S.A. 1989)
    10. Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma. (PubMed id 2740341)1, 3 Finger L.R....Croce C.M. (Proc. Natl. Acad. Sci. U.S.A. 1989)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6886 HGNC: 11556 AceView: TAL1 Ensembl:ENSG00000162367 euGenes: HUgn6886
    ECgene: TAL1 H-InvDB: TAL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TAL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TAL1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TAL1 gene:
    Search GeneIP for patents involving TAL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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