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Aliases & Descriptions for TAGLN3
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases NP22 1 , 2 , 3 NP25 1 , 2 , 3
Descriptions Neuronal protein 22 3 Neuronal protein NP25 3 neuronal protein 2 transgelin 3 2
Search outside databases for aliases for TAGLN3 gene
Summaries for TAGLN3 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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Gene Wiki entry for TAGLN3
Genomic Location for TAGLN3
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the TAGLN3 gene Entrez Gene cytogenetic band: 3q13.2 Ensembl cytogenetic band: 3q13.2 HGNC cytogenetic band: 3q13.2 TAGLN3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03P113201:
(about GC identifiers )
Start:
113,200,276 bp from pter
End:
113,215,425 bp from pter
Size:
15,150 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000003.10 NT_005612.15 Proteins for TAGLN3
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: TAGL3_HUMAN, Q9UI15 (See
protein sequence )Recommended Name: Transgelin-3 Size : 199 amino acids; 22473 Da
Sequence caution : Sequence=AAF17189.1; Type=Frameshift; Positions=199;
Secondary accessions : Q96A74
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (3 alternative transcripts):
NP_001008273.1 NP_001008274.1 NP_037391.2 ENSEMBL proteins: ENSP00000377494 ENSP00000273368 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: TAGLN3 Antibodies for TAGLN3: Assays for TAGLN3:
Protein
Domains/ Families for TAGLN3(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9UI15 ProtoNet protein and cluster: Q9UI15
3 Blocks protein families : IPB001061 Smooth muscle protein 22-alpha (transgelin) signature IPB001715 Calponin-like actin-binding IPB003247 Calponin-like actin-binding subtype UniProtKB/Swiss-Prot: TAGL3_HUMAN, Q9UI15 Similarity : Belongs to the calponin familySimilarity : Contains 1 calponin-like repeatSimilarity : Contains 1 CH (calponin-homology) domain
Gene Function for TAGLN3
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
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Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_001008272 Applied Biosystems Silencer ® siRNAs for TAGLN3 Sigma-Aldrich siRNA for TAGLN3 Sigma-Aldrich shRNA for TAGLN3 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001008272                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001008272                                  untagged cDNA clones in CMV expression vector (see all 4 ): NM_001008272  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001008272 Pathways & Interactions for TAGLN3
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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2 Interacting proteins for TAGLN3 (ENSP00000273368 3 ) via UniProtKB, MINT, and/or STRING About this table 2 Gene Ontology (GO) biological process terms (links to tree view) :
About this table
Drugs & Compounds for TAGLN3 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for TAGLN3
Transcripts for TAGLN3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_001008272 Sigma-Aldrich siRNA for TAGLN3 Sigma-Aldrich shRNA for TAGLN3 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001008272 NM_001008273 NM_013259
REFSEQ mRNAs for TAGLN3 gene (3 alternative transcripts): NM_001008272.1 NM_001008273.1 NM_013259.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001008272 NM_001008273 NM_013259
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001008272                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001008272                                  untagged cDNA clones in CMV expression vector (see all 4 ): NM_001008272  
Additional cDNA sequence: AF087855.1 AF112201.1 AF303058.1 AK315289.1 BC015329.1 BT007408.1 CR591700.1 CR600116.1
7 DOTS entries : DT.101981687 DT.92447519 DT.92447508 DT.100779058 DT.120900008 DT.40119930 DT.92447509
24/132 AceView cDNA sequences (see all 132
):BC015329 R54518 H22053 AA973428 BU728809 BM669668 AI801870 CR600116 BQ549712 AW205010 BM894229 BQ719637 BT007408 BM894501 BF346837 BM857481 BM704283 AA322467 AW298406 CR591700 BX096730 BM547950 T23580 BM687917
highest scoring ESTs for TAGLN3 :Z78388 AA322467 AA932793 AA973428 AF087855 AF112201 AF303058 AI002922 AI032263 AI084120
Unigene Cluster for TAGLN3: Transgelin 3 Hs.169330 [show with all ESTs ] Unigene Representative Sequence: NM_013259 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for TAGLN3 ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b SP1 :       -   -               SP2 :       -   -   -             SP3 :       -                 SP4 :                      
About this scheme ECgene alternative splicing isoforms for TAGLN3 2 Ensembl transcripts including schematic representations : ENST00000393917
ENST00000273368
Expression for TAGLN3
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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TAGLN3 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for TAGLN3 1 / 2 / 3
4 probe-sets matching TAGLN3 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GTCTCTACGASOURCE GeneReport for Unigene cluster: Hs.169330 UniProtKB/Swiss-Prot: TAGL3_HUMAN, Q9UI15 Tissue specificity : Widely expressed in the brain. Expression is increased in the superior frontalcortex of alcoholics, but not in the motor cortex or cerebellum
Orthologs for TAGLN3
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for TAGLN3 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for TAGLN3 ENSEMBL Gene Tree for TAGLN3 Paralogs for TAGLN3 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for TAGLN3 gene TAGLN2 2 TAGLN 2
SNPs/Variants for TAGLN3 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for TAGLN3 (up to first 250kb)
Disorders & Mutations for TAGLN3
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 607953
Medical News for TAGLN3 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for TAGLN3 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/13 PubMed articles for TAGLN3 gene (see all 13
): Molecular cloning and characterization of hNP22: a gene up-regulated in human alcoholic brain. (PubMed id 11238712) 1, 2, 3, 4 Fan L....Wilce P.A. (2001) The identification of NP25: a novel protein that is differentially expressed by neuronal subpopulations. (PubMed id 8015377) 1, 2, 3 Ren W.Z....Liew C.C. (1994) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946) 3, 4 Hu R.-M.... Chen J.-L. (2000) Expression of human neuronal protein 22, a novel cytoskeleton-associated protein, was decreased in the anterior cingulate cortex of schizophrenia. (PubMed id 15781144) 1, 3 Ito M....Matsumoto I. (2005) Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. (PubMed id 18083107) 4 Rikova K....Comb M.J. (2007) Expression of hNP22 is altered in the frontal cortex and hippocampus of the alcoholic human brain. (PubMed id 14506410) 3 Depaz I....Wilce P.A. (2003) Expressed sequence tag analysis of human retina for the NEIBank project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. (PubMed id 12107411) 3 Wistow G.... Peterson K. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002) Neuronal protein NP25 interacts with F-actin. (PubMed id 15041197) 1 Mori K....Sakai N. (2004)
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Genome Databases showing TAGLN3
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing TAGLN3
(According to HUGE )
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Specialized Databases showing TAGLN3 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for TAGLN3 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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