Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAGLN3 Gene

protein-coding   GIFtS: 50
GCID: GC03P111717

transgelin 3
 Explore 7 diseases affiliated with
TAGLN3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TAGLN3    

Aliases
for TAGLN3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Transgelin 31 2
NP221 2 3
NP251 2 3
Neuronal Protein 222 3
Neuronal Protein NP252 3
Transgelin-31

External Ids:    HGNC: 298681   Entrez Gene: 291142   Ensembl: ENSG000001448347   OMIM: 6079535   UniProtKB: Q9UI153   

Export aliases for TAGLN3 gene to outside databases

Previous GC identifers: GC03P113201 GC03P109092


Summaries
for TAGLN3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Gene Wiki entry for TAGLN3


Genomic Views
for TAGLN3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAGLN3 gene promoter:
         GR   AP-1   GR-alpha   STAT5A   Ik-3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TAGLN3 promoter sequence
   Search SABiosciences Chromatin IP Primers for TAGLN3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAGLN3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.2   Ensembl cytogenetic band:  3q13.2   HGNC cytogenetic band: 3q13.2

TAGLN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAGLN3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P111717:  view genomic region     (about GC identifiers)

Start:
 111,717,511 bp from pter      End:
 111,732,735 bp from pter
Size:
 15,225 bases      Orientation:
 plus strand

Proteins
for TAGLN3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TAGL3_HUMAN, Q9UI15 (See protein sequence)
Recommended Name: Transgelin-3  
Size: 199 amino acids; 22473 Da
Sequence caution: Sequence=AAF17189.1; Type=Frameshift; Positions=199;
Secondary accessions: D3DN64 Q96A74

Explore the universe of human proteins at neXtProt for TAGLN3: NX_Q9UI15

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UI15

    • TAGLN3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001008273.1  NP_001008274.1  NP_037391.2  

    ENSEMBL proteins: 
     ENSP00000419105   ENSP00000273368   ENSP00000391160   ENSP00000420675   ENSP00000417904  
     ENSP00000420346   ENSP00000377494  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 3): TAGLN3
    OriGene Protein Over-expression Lysate (see all 5): TAGLN3
    OriGene Custom Protein Services for TAGLN3 
    GenScript Custom Purified and Recombinant Proteins Services for TAGLN3
    Novus Biologicals TAGLN3 Proteins
    Novus Biologicals TAGLN3 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for TAGLN3
    Uscn Proteins for TAGLN3

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    TAGLN3 for ontologies           About GeneDecksing



    TAGLN3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TAGLN3 
    GenScript Custom Superior Antibodies Services for TAGLN3
    Novus Biologicals TAGLN3 Antibodies
    Search for Antibodies for TAGLN3 at Abcam  
    Uscn Antibodies for TAGLN3
    Search ThermoFisher Antibodies for TAGLN3

    Assay Products for TAGLN3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TAGLN3
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TAGLN3

    Protein Domains /
    Families
    for TAGLN3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TAGLN3 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001061 TAGLN
     IPR001715 CH-domain
     IPR003096 SM22_calponin
     IPR000557 Calponin_repeat

    Graphical View of Domain Structure for InterPro Entry Q9UI15

    ProtoNet protein and cluster: Q9UI15

    3 Blocks protein families:
    IPB001061 Smooth muscle protein 22-alpha (transgelin) signature
    IPB001715 Calponin-like actin-binding
    IPB003247 Calponin-like actin-binding subtype


    UniProtKB/Swiss-Prot: TAGL3_HUMAN, Q9UI15
    Similarity: Belongs to the calponin family
    Similarity: Contains 1 calponin-like repeat
    Similarity: Contains 1 CH (calponin-homology) domain


    Function
    for TAGLN3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 3): TAGLN3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TAGLN3
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate TAGLN3:
    hsa-miR-153 hsa-miR-182 hsa-miR-448 hsa-miR-3168 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmid: TAGLN3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TAGLN3 (see all 7)
    OriGene shRNA RFP: TAGLN3
    OriGene siRNA: TAGLN3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAGLN3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TAGLN3

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAGLN3 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAGLN3 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): TAGLN3 (NM_001008272)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAGLN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAGLN3 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TAGLN3
    LifeMap BioReagents: cell line associated with TAGLN3: PureStem Progenitor E68

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAGLN3

    2 GenomeRNAi human phenotypes for TAGLN3:
     Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for TAGLN3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAGLN3

    4 Interacting proteins for TAGLN3 (Q9UI153) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SARS2Q9NP813I2D: score=5 
    SLC25A37Q9NYZ23I2D: score=5 
    CRYABP025113I2D: score=1 
    DLG4P783523I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0007417central nervous system development TAS8015377
    GO:0007517muscle organ development IEA--


    TAGLN3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TAGLN3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TAGLN3
    Search CenterWatch for drugs/clinical trials and news about TAGLN3 / TAGL3 

    Transcripts
    for TAGLN3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TAGLN3 gene (3 alternative transcripts): 
    NM_001008272.1  NM_001008273.1  NM_013259.2  

    Unigene Cluster for TAGLN3:

    Transgelin 3
    Hs.169330  [show with all ESTs]
    Unigene Representative Sequence: NM_013259
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000478951 ENST00000273368 ENST00000455401(uc003dyo.3) ENST00000494932
    ENST00000486460 ENST00000469385 ENST00000393917(uc003dym.3 uc003dyl.3 uc003dyn.3)


    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 3): TAGLN3
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TAGLN3
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate TAGLN3:
    hsa-miR-153 hsa-miR-182 hsa-miR-448 hsa-miR-3168 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmid: TAGLN3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TAGLN3 (see all 7)
    OriGene shRNA RFP: TAGLN3
    OriGene siRNA: TAGLN3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAGLN3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAGLN3 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAGLN3 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): TAGLN3 (NM_001008272)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAGLN3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAGLN3 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAGLN3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TAGLN3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAGLN3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAGLN3

    Additional cDNA sequence: 

    AF087855.1 AF112201.1 AF303058.1 AK315289.1 BC015329.1 BT007408.1 

    7 DOTS entries:

    DT.101981687  DT.92447519  DT.92447508  DT.100779058  DT.120900008  DT.40119930  DT.92447509 

    24/132 AceView cDNA sequences (see all 132):

    AA973428 AI801870 BM894501 CR591700 BF346837 BM669668 AA322467 BM894229 
    BC015329 BU728809 BM857481 AW205010 AW298406 BM704283 BQ549712 CR600116 
    BT007408 BQ719637 H22053 R54518 BM691560 T33516 CK003985 BM547950 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TAGLN3    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b
    SP1:                    -     -                                       
    SP2:                    -     -     -                                 
    SP3:                    -                                             
    SP4:                                                                  


    ECgene alternative splicing isoforms for TAGLN3

    Expression
    for TAGLN3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TAGLN3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTCTCTACGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TAGLN3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    EyeInner Nuclear LayerMature Horizontal CellsHorizontal, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 6 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)
    Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

    See TAGLN3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TAGLN3

    SOURCE GeneReport for Unigene cluster: Hs.169330

    UniProtKB/Swiss-Prot: TAGL3_HUMAN, Q9UI15
    Tissue specificity: Widely expressed in the brain. Expression is increased in the superior frontal cortex of
    alcoholics, but not in the motor cortex or cerebellum

        SABiosciences Custom PCR Arrays for TAGLN3
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAGLN3
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TAGLN3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAGLN3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAGLN3
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAGLN3

    Orthologs
    for TAGLN3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TAGLN3 gene from 5/20 species (see all 20)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TAGLN31 transgelin 3 80.74(n)
    88.44(a)    		   418420  XM_416634.3  XP_416634.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TAGLN36
    		 --
    		 87(a)
    		 1 ↔ 1
    		 3(167697308-167708598)
    zebrafish
    (Danio rerio)    		 Actinopterygii wufc80d072 wufc80d07 77.73(n)   325474  BC062382.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Chd646
    Mp206
    (see all 3)    		 Muscle protein 20
    (see all 3)    		 45(a)
    43(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 3L(4114289-4122388)
    2R(9134175-9135264)
    worm
    (Caenorhabditis elegans)    		 Secernentea cpn-21 Protein CPN-2 46.22(n)
    42.27(a)    		   173424  NM_061312.2  NP_493713.2 


    ENSEMBL Gene Tree for TAGLN3 (if available)
    TreeFam Gene Tree for TAGLN3 (if available) 

    Paralogs
    for TAGLN3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TAGLN3 gene
    TAGLN22  TAGLN2  CNN12  CNN32  CNN22  
    5 SIMAP similar genes for TAGLN3 using alignment to 4 protein entries:     TAGL3_HUMAN (see all proteins):
    TAGLN2    TAGLN    CNN3    CNN2    CNN1

    TAGLN3 for paralogs           About GeneDecksing



    Genomic Variants
    for TAGLN3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/360 NCBI SNPs in TAGLN3 are shown (see all 360)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs76277441,2
    		C,F,A,H,--111715635(+) ATTGCG/ACCCCA 2 -- us2k18Minor allele frequency- A:0.34WA NA CSA EA 368
    rs113568871,2
    		C,--111715669(+) GAATC-/AAAAAA 2 -- us2k1 trp31Minor allele frequency- A:0.50CSA 2
    rs1166717981,2
    		--111715700(+) AAAACA/GTTAAC 2 -- us2k11Minor allele frequency- G:0.01WA 118
    rs779819341,2
    		C,--111715760(+) TGTCAC/ACCCTG 2 -- us2k13Minor allele frequency- A:0.03CSA NA EA 242
    rs1894769101,2
    		--111715811(+) TTCTGA/GACACT 2 -- us2k10--------
    rs1819576001,2
    		--111715885(+) ATTCAA/CTTAAA 2 -- us2k10--------
    rs1407196351,2
    		--111715904(+) GCTACG/TCTGTT 2 -- us2k10--------
    rs1142541091,2
    		F,--111715994(+) GAATTG/CTTTCA 2 -- us2k11Minor allele frequency- C:0.08WA 118
    rs1501024851,2
    		--111716044(+) CCAGCC/TATGGA 3 -- us2k10--------
    rs38117051,2
    		C,F,A,H,--111716195(-) GGACAC/TTTGGA 3 -- us2k123Minor allele frequency- T:0.34NS EA WA NA CSA 2352

    HapMap Linkage Disequilibrium report for TAGLN3 (111717511 - 111732735 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TAGLN3: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAGLN3
    DNA2.0 Custom Variant and Variant Library Synthesis for TAGLN3

    Disorders / Diseases
    for TAGLN3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TAGLN3 for disorders           About GeneDecksing

    OMIM gene information: 607953    OMIM disorders: --

    7 diseases for TAGLN3:    About MalaCards
    neuronitis    alcohol dependence    pick's disease    down syndrome
    alcoholism    retinitis    schizophrenia


    Export disorders for TAGLN3 gene to outside databases

    Publications
    for TAGLN3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TAGLN3 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with TAGLN3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of hNP22: a gene up-regulated in human alcoholic brain. (PubMed id 11238712)1, 2, 3, 9 Fan L.... Wilce P.A. (2001)
    2. The identification of NP25: a novel protein that is differentially expressed by neuronal subpopulations. (PubMed id 8015377)1, 3, 9 Ren W.Z....Liew C.C. (1994)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    5. Expression of human neuronal protein 22, a novel cytoskeleton-associated protein, was decreased in the anterior cingulate cortex of schizophrenia. (PubMed id 15781144)1, 9 Ito M....Matsumoto I. (2005)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    9. Expression of hNP22 is altered in the frontal cortex and hippocampus of the alcoholic human brain. (PubMed id 14506410)1 Depaz I....Wilce P.A. (2003)
    10. Expressed sequence tag analysis of human retina for the NEIBank project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. (PubMed id 12107411)1 Wistow G.... Peterson K. (2002)

    External Searches for TAGLN3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TAGLN3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 29114 HGNC: 29868 AceView: NP25 Ensembl:ENSG00000144834 euGenes: HUgn29114
    ECgene: TAGLN3 H-InvDB: TAGLN3

    Other Databases showing TAGLN3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TAGLN3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TAGLN3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TAGLN3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TAGLN3 gene:
    Search GeneIP for patents involving TAGLN3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for TAGLN3 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for TAGLN3  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TAGLN3   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAGLN3  
     OriGene Protein Over-expression Lysate for TAGLN3   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for TAGLN3   OriGene 3'-UTR Clone for TAGLN3  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAGLN3   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAGLN3  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for TAGLN3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TAGLN3   OriGene Custom Protein Services for TAGLN3  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TAGLN3
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAGLN3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAGLN3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAGLN3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAGLN3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAGLN3
     GenScript Custom Purified and Recombinant Proteins Services for TAGLN3 GenScript cDNA clones with any tag delivered in your preferred vector for TAGLN3
     GenScript Custom Assay Services for TAGLN3 GenScript Custom Superior Antibodies Services for TAGLN3
     GenScript Custom overexpressing Cell Line Services for TAGLN3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TAGLN3 promoter
     Search Chromatin IP Primers for TAGLN3
     RT2 qPCR Primer Assay in human, mouse, rat TAGLN3
     Search GNC Networks for TAGLN3
     SABiosciences Custom PCR Arrays for TAGLN3
     Search Tocris compounds for TAGLN3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TAGLN3 antibodies
     TAGLN3 proteins
     TAGLN3 lysates
     Search for Antibodies for TAGLN3 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for TAGLN3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for TAGLN3




     TAGLN3 Proteins, Antibodies, CLIAs, and ELISAs
     Cell Line associated with TAGLN3: PureStem Progenitor E68
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAGLN3
     SwitchGear 3'UTR luciferase reporter plasmids for TAGLN3
     SwitchGear Promoter luciferase reporter plasmids for TAGLN3
     Search ThermoFisher Antibodies for TAGLN3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAGLN3
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      TAGLN3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4