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TAGLN3 Gene

protein-coding   GIFtS: 53

GC03P113201
transgelin 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
NP22 1, 2, 3
NP25 1, 2, 3
Descriptions
Neuronal protein 22 3
Neuronal protein NP25 3
neuronal protein 2
transgelin 3 2
External Ids
HGNC: 298681
Entrez Gene: 291142
UniProtKB: Q9UI153
Ensembl: ENSG000001448347
Search outside databases for aliases for TAGLN3 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Gene Wiki entry for TAGLN3
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the TAGLN3 gene  

Entrez Gene cytogenetic band: 3q13.2   Ensembl cytogenetic band:  3q13.2   HGNC cytogenetic band: 3q13.2

TAGLN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P113201:     (about GC identifiers)

Start:
113,200,276 bp from pter
End:
113,215,425 bp from pter
Size:
15,150 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000003.10  NT_005612.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TAGL3_HUMAN, Q9UI15 (See protein sequence)
Recommended Name: Transgelin-3  
Size: 199 amino acids; 22473 Da
Sequence caution: Sequence=AAF17189.1; Type=Frameshift; Positions=199;
Secondary accessions: Q96A74

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (3 alternative transcripts): 
    NP_001008273.1  NP_001008274.1  NP_037391.2  


    ENSEMBL proteins: 
    ENSP00000377494 ENSP00000273368 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (TAGLN3)
    Human Recombinant Proteins from Abnova (TAGLN3)
                  OriGene Purified Recombinant Human Protein: TAGLN3 


    Antibodies for TAGLN3: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for TAGLN3
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (TAGLN3), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (TAGLN3)
    Novus Biologicals Antibody for TAGLN3

    Assays for TAGLN3: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    4 InterPro domains/families:
     IPR001061 Transgelin
     IPR001715 Calponin_act_bd
     IPR003096 SM22_calponin
     IPR000557 Calponin_repeat


       GeneDecks  TAGLN3 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9UI15

    ProtoNet protein and cluster: Q9UI15

    3 Blocks protein families:
    IPB001061 Smooth muscle protein 22-alpha (transgelin) signature
    IPB001715 Calponin-like actin-binding
    IPB003247 Calponin-like actin-binding subtype


    UniProtKB/Swiss-Prot: TAGL3_HUMAN, Q9UI15
    Similarity: Belongs to the calponin family
    Similarity: Contains 1 calponin-like repeat
    Similarity: Contains 1 CH (calponin-homology) domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (TAGLN3)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (TAGLN3)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001008272

                  Applied Biosystems Silencer® siRNAs for TAGLN3

                  Sigma-Aldrich siRNA for TAGLN3  
                         Sigma-Aldrich shRNA for TAGLN3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for TAGLN3
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001008272
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001008272
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_001008272 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001008272

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    2 Interacting proteins for TAGLN3 (ENSP000002733683) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LIM2ENSP000002219733STRING (score=.861)
    NDUFB11ENSP000002760623STRING (score=.734)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007417 central nervous system development TAS8015377
    GO:0007517 muscle development IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for TAGLN3

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (TAGLN3)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (TAGLN3)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_001008272

                  Sigma-Aldrich siRNA for TAGLN3  
                         Sigma-Aldrich shRNA for TAGLN3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001008272  NM_001008273  NM_013259  

    REFSEQ mRNAs for TAGLN3 gene (3 alternative transcripts): 

    NM_001008272.1   NM_001008273.1   NM_013259.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001008272  NM_001008273  NM_013259  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001008272
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001008272
                                     untagged cDNA clones in CMV expression vector (see all 4): NM_001008272 

    Additional cDNA sequence: 

    AF087855.1 AF112201.1 AF303058.1 AK315289.1 BC015329.1 BT007408.1 CR591700.1 CR600116.1 

    7 DOTS entries:

    DT.101981687  DT.92447519  DT.92447508  DT.100779058  DT.120900008  DT.40119930  DT.92447509 

    24/132 AceView cDNA sequences (see all 132 ):

    BC015329 R54518 H22053 AA973428 BU728809 BM669668 AI801870 CR600116 
    BQ549712 AW205010 BM894229 BQ719637 BT007408 BM894501 BF346837 BM857481 
    BM704283 AA322467 AW298406 CR591700 BX096730 BM547950 T23580 BM687917 

    highest scoring ESTs for TAGLN3:

    Z78388 AA322467 AA932793 AA973428 AF087855 AF112201 AF303058 AI002922 AI032263 AI084120 

    Unigene Cluster for TAGLN3:

    Transgelin 3
    Hs.169330  [show with all ESTs]
    Unigene Representative Sequence: NM_013259


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TAGLN3

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b
    SP1:                    -     -                                       
    SP2:                    -     -     -                                 
    SP3:                    -                                             
    SP4:                                                                  

    About this scheme

    ECgene alternative splicing isoforms for TAGLN3

    2 Ensembl transcripts including schematic representations:
    ENST00000393917  ENST00000273368  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    TAGLN3 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for TAGLN3

    1 / 2 / 3

    4 probe-sets matching TAGLN3 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    32650_at2, 3 U95-A 1 1.00 1.00 0.98 1.32 Z78388 1.00 1.00 1.00 1
    32652_g_at2, 3 U95-A 1 1.00 1.00 0.99 0.75 W28770 0.40 1.00 0.76 1

    204743_at2, 3 U133-A 1 1.00 1.00 -- -- NM_013259 0.60 1.00 0.82 1

    204743_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  TAGLN3 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GTCTCTACGA

    SOURCE GeneReport for Unigene cluster: Hs.169330

    UniProtKB/Swiss-Prot: TAGL3_HUMAN, Q9UI15
    Tissue specificity: Widely expressed in the brain. Expression is increased in the superior frontal
    cortex of alcoholics, but not in the motor cortex or cerebellum

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for TAGLN3 gene from 5/10 species (see all 10 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    TAGLN31   -- transgelin 3 92.8(n)
    98.49(a)
    478562  XM_535738.2  XP_535738.1 
    chimpanzee
    (Pan troglodytes)
    TAGLN31   -- transgelin 3 99.5(n)
    100(a)
    460579  XM_001154213.1  XP_001154213.1 
    cow
    (Bos taurus)
    TAGLN31   -- transgelin 3 94.3(n)
    99.5(a)
    515562  NM_001034499.1  NP_001029671.1 
    rat
    (Rattus norvegicus)
    Tagln31   -- transgelin 3 92.96(n)
    98.99(a)
    63837  NM_001035236.1  NP_001030313.1 
    mouse
    (Mus musculus)
    Tagln31, 5 165
    transgelin 31, 5 93.63(n)1
    99.5(a)1
    563701  NM_019754.31  NP_062728.11 
     AB0312915  AI4260075  (see all 8)
    About this table        Species with no ortholog for TAGLN3

    ENSEMBL Gene Tree for TAGLN3
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for TAGLN3 gene
    TAGLN22  TAGLN2  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/139 NCBI SNPs in TAGLN3 are shown (see all 139 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 101)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 3 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs80701,2
    A,C,F,H,O113215298(+) CTTCCG/ATTTTC 3 -- ut31 ese314Minor allele frequency- A:0.29MN EU EA WA 1628
    rs10580621,2
    A,C,F,H,O113200596(+) AGAAGG/CGGGAA 3 -- ut51 ng51 trp36Minor allele frequency- C:0.25EA MN EU WA 2098
    rs28953891,2
    A,C,F,H,O113199125(+) AGGCAT/CCAGCC 3 -- ng5112Minor allele frequency- C:0.33EU EA WA NA 1046
    rs38117051,2
    A,C,F,H113198885(-) GGACAC/TTTGGA 3 -- ng518Minor allele frequency- T:0.30EU EA WA 804
    rs19947331,2
    C,F,H113215452(-) AGTCCC/TTAAGA 3 -- ng318Minor allele frequency- T:0.05EU EA WA 832
    rs119201391,2
    C,F,H113199046(+) GCCTTC/TAACGA 3 -- ng514Minor allele frequency- T:0.04EU EA WA 406
    rs23994011,2
    C,F,O113199221(+) CATCAT/ACCCAT 3 -- ng513Minor allele frequency- A:0.30NA 140
    rs119243541,2
    C,F,H113199414(+) AGAATT/CACACA 3 -- ng514Minor allele frequency- C:0.01EU EA WA 418
    --
    rs76277441,2
    A,C113198325(+) attgcA/Gcccca 2 -- ng510--------
    rs22806811,2
    C,F113200716(-) tccagG/CGGGGC 3 -- int1 ut511Minor allele frequency- C:0.29EA 1500
    About this table

    HapMap Linkage Disequilibrium images for TAGLN3 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 607953

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/13 PubMed articles for TAGLN3 gene (see all 13 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 29114 HGNC: 29868 AceView: NP25 Ensembl:ENSG00000144834 euGenes: HUgn29114
    ECgene: TAGLN3 H-InvDB: TAGLN3
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for TAGLN3:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for TAGLN3-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for TAGLN3 Antibodies for TAGLN3
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for TAGLN3 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant Proteins
    (TAGLN3)
     Antibodies (TAGLN3)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for TAGLN3




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for TAGLN3

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