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Aliases for TAGLN3 Gene

Aliases for TAGLN3 Gene

  • Transgelin 3 2 3
  • NP22 3 4 6
  • Neuronal Protein NP25 3 4
  • Neuronal Protein 22 3 4
  • NP24 3 6
  • NP25 3 4
  • Transgelin-3 3

External Ids for TAGLN3 Gene

Summaries for TAGLN3 Gene

GeneCards Summary for TAGLN3 Gene

TAGLN3 (Transgelin 3) is a Protein Coding gene. An important paralog of this gene is CNN3.

Gene Wiki entry for TAGLN3 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAGLN3 Gene

Genomics for TAGLN3 Gene

Genomic Location for TAGLN3 Gene

Start:
111,998,664 bp from pter
End:
112,013,888 bp from pter
Size:
15,225 bases
Orientation:
Plus strand

Genomic View for TAGLN3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAGLN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAGLN3 Gene

Regulatory Elements for TAGLN3 Gene

Proteins for TAGLN3 Gene

  • Protein details for TAGLN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UI15-TAGL3_HUMAN
    Recommended name:
    Transgelin-3
    Protein Accession:
    Q9UI15
    Secondary Accessions:
    • D3DN64
    • Q96A74

    Protein attributes for TAGLN3 Gene

    Size:
    199 amino acids
    Molecular mass:
    22473 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF17189.1; Type=Frameshift; Positions=199; Evidence={ECO:0000305};

neXtProt entry for TAGLN3 Gene

Proteomics data for TAGLN3 Gene at MOPED

Post-translational modifications for TAGLN3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TAGLN3 Gene

Domains for TAGLN3 Gene

Suggested Antigen Peptide Sequences for TAGLN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UI15

UniProtKB/Swiss-Prot:

TAGL3_HUMAN
Domain:
  • Contains 1 CH (calponin-homology) domain.:
    • Q9UI15
Family:
  • Belongs to the calponin family.:
    • Q9UI15
Similarity:
  • Contains 1 calponin-like repeat.:
    • Q9UI15
genes like me logo Genes that share domains with TAGLN3: view

No data available for Gene Families for TAGLN3 Gene

Function for TAGLN3 Gene

Gene Ontology (GO) - Molecular Function for TAGLN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0051015 actin filament binding IEA --
genes like me logo Genes that share ontologies with TAGLN3: view

Phenotypes for TAGLN3 Gene

genes like me logo Genes that share phenotypes with TAGLN3: view

miRNA for TAGLN3 Gene

miRTarBase miRNAs that target TAGLN3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TAGLN3 Gene

Localization for TAGLN3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAGLN3 Gene COMPARTMENTS Subcellular localization image for TAGLN3 gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TAGLN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TAGLN3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TAGLN3 Gene

Pathways for TAGLN3 Gene

SuperPathways for TAGLN3 Gene

No Data Available

Interacting Proteins for TAGLN3 Gene

Gene Ontology (GO) - Biological Process for TAGLN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0007417 central nervous system development TAS 8015377
genes like me logo Genes that share ontologies with TAGLN3: view

No data available for Pathways by source for TAGLN3 Gene

Transcripts for TAGLN3 Gene

Unigene Clusters for TAGLN3 Gene

Transgelin 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAGLN3 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b
SP1: - -
SP2: - - -
SP3: -
SP4:

Relevant External Links for TAGLN3 Gene

GeneLoc Exon Structure for
TAGLN3
ECgene alternative splicing isoforms for
TAGLN3

Expression for TAGLN3 Gene

mRNA expression in normal human tissues for TAGLN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TAGLN3 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (6.8), Brain - Frontal Cortex (BA9) (6.6), Brain - Cortex (6.0), and Brain - Amygdala (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAGLN3 Gene

SOURCE GeneReport for Unigene cluster for TAGLN3 Gene Hs.169330

mRNA Expression by UniProt/SwissProt for TAGLN3 Gene

Q9UI15-TAGL3_HUMAN
Tissue specificity: Widely expressed in the brain. Expression is increased in the superior frontal cortex of alcoholics, but not in the motor cortex or cerebellum
genes like me logo Genes that share expressions with TAGLN3: view

Orthologs for TAGLN3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAGLN3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAGLN3 35
  • 99.5 (n)
  • 100 (a)
TAGLN3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAGLN3 35
  • 94.3 (n)
  • 99.5 (a)
TAGLN3 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAGLN3 35
  • 92.8 (n)
  • 98.49 (a)
TAGLN3 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tagln3 35
  • 93.63 (n)
  • 99.5 (a)
Tagln3 16
Tagln3 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAGLN3 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAGLN3 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tagln3 35
  • 92.96 (n)
  • 98.99 (a)
chicken
(Gallus gallus)
Aves TAGLN3 35
  • 80.74 (n)
  • 88.44 (a)
TAGLN3 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAGLN3 36
  • 87 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tagln3a 36
  • 71 (a)
OneToMany
tagln3b 35
  • 71.52 (n)
  • 79.9 (a)
tagln3b 36
  • 80 (a)
OneToMany
wufc80d07 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000748 35
  • 54.07 (n)
  • 43.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta Chd64 36
  • 44 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea cpn-2 35
  • 46.05 (n)
  • 42.27 (a)
cpn-2 36
  • 40 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCP1 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
ManyToMany
CSA.10356 36
  • 42 (a)
ManyToMany
Species with no ortholog for TAGLN3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TAGLN3 Gene

ENSEMBL:
Gene Tree for TAGLN3 (if available)
TreeFam:
Gene Tree for TAGLN3 (if available)

Paralogs for TAGLN3 Gene

Paralogs for TAGLN3 Gene

Selected SIMAP similar genes for TAGLN3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TAGLN3: view

Variants for TAGLN3 Gene

Sequence variations from dbSNP and Humsavar for TAGLN3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs8070 -- 112,013,761(+) CTTCC(A/G)TTTTC utr-variant-3-prime
rs774752 -- 112,006,876(-) TCTGC(A/T)TTGTA intron-variant
rs774753 -- 112,006,599(+) ATATA(C/T)AATAG intron-variant
rs774754 -- 112,006,587(+) GAGTC(A/C)AGACT intron-variant
rs774755 -- 112,005,824(+) CCTCC(C/T)GAGTA intron-variant

Relevant External Links for TAGLN3 Gene

HapMap Linkage Disequilibrium report
TAGLN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TAGLN3 Gene

Disorders for TAGLN3 Gene

No disorders were found for TAGLN3 Gene.

No data available for UniProtKB/Swiss-Prot for TAGLN3 Gene

Publications for TAGLN3 Gene

  1. Molecular cloning and characterization of hNP22: a gene up-regulated in human alcoholic brain. (PMID: 11238712) Fan L. … Wilce P.A. (J. Neurochem. 2001) 2 3 4 23
  2. The identification of NP25: a novel protein that is differentially expressed by neuronal subpopulations. (PMID: 8015377) Ren W.Z. … Liew C.C. (Brain Res. Mol. Brain Res. 1994) 2 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Expression of human neuronal protein 22, a novel cytoskeleton-associated protein, was decreased in the anterior cingulate cortex of schizophrenia. (PMID: 15781144) Ito M. … Matsumoto I. (Neurosci. Lett. 2005) 3 23
  5. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4

Products for TAGLN3 Gene

Sources for TAGLN3 Gene

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