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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAGLN2 Gene

protein-coding   GIFtS: 58
GCID: GC01M159887

Transgelin 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transgelin 21 2
SM22-Alpha Homolog1 2 3
Epididymis Tissue Protein Li 7e2 3
HA17562
transgelin-22
KIAA01203

External Ids:    HGNC: 115541   Entrez Gene: 84072   Ensembl: ENSG000001587107   OMIM: 6046345   UniProtKB: P378023   

Export aliases for TAGLN2 gene to outside databases

Previous GC identifers: GC01M157680 GC01M155620 GC01M156665 GC01M157104 GC01M156700 GC01M158108 GC01M158154 GC01M131244


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TAGLN2 Gene:
The protein encoded by this gene is similar to the protein transgelin, which is one of the earliest markers of
differentiated smooth muscle. The specific function of this protein has not yet been determined, although it is
thought to be a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Mar 2013)

GeneCards Summary for TAGLN2 Gene: 
TAGLN2 (transgelin 2) is a protein-coding gene. Diseases associated with TAGLN2 include neural tube defects, and epididymitis. GO annotations related to this gene include protein binding. An important paralog of this gene is TAGLN.

Gene Wiki entry for TAGLN2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAGLN2 gene promoter:
         Pax-2   Pax-2a   Nkx2-5   Tal-1beta   GATA-1   AREB6   PPAR-gamma1   PPAR-gamma2   ITF-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAGLN2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TAGLN2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAGLN2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21-q25   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q21-q25

TAGLN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAGLN2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M159887:  view genomic region     (about GC identifiers)

Start:
159,887,897 bp from pter      End:
159,895,522 bp from pter
Size:
7,626 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TAGL2_HUMAN, P37802 (See protein sequence)
Recommended Name: Transgelin-2  
Size: 199 amino acids; 22391 Da
Sequence caution: Sequence=AAG01993.1; Type=Erroneous initiation; Sequence=BAA04802.2; Type=Erroneous initiation;
Sequence=CAI14604.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for TAGLN2:
1WYM (3D)    
Secondary accessions: E9KL39 Q5JRQ6 Q5JRQ7 Q6FGI1 Q9BUH5 Q9H4P0

Explore the universe of human proteins at neXtProt for TAGLN2: NX_P37802

Explore proteomics data for TAGLN2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P37802

  • TAGLN2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TAGLN2 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001264152.1  NP_001264153.1  NP_003555.1  

    ENSEMBL proteins: 
     ENSP00000357076   ENSP00000357077   ENSP00000357075   ENSP00000412429  

    Human Recombinant Protein Products for TAGLN2: 
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    OriGene MassSpec for TAGLN2 
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    Novus Biologicals TAGLN2 Proteins
    Novus Biologicals TAGLN2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for TAGLN2
    Cloud-Clone Corp. Proteins for TAGLN2 


    TAGLN2 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for TAGLN2 

    Assay Products for TAGLN2: 
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    Cloud-Clone Corp. ELISAs for TAGLN2 
    Cloud-Clone Corp. CLIAs for TAGLN2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR001061 TAGLN
     IPR001715 CH-domain
     IPR003096 SM22_calponin
     IPR000557 Calponin_repeat

    Graphical View of Domain Structure for InterPro Entry P37802

    ProtoNet protein and cluster: P37802

    3 Blocks protein domains:
    IPB001061 Smooth muscle protein 22-alpha (transgelin) signature
    IPB001715 Calponin-like actin-binding
    IPB003247 Calponin-like actin-binding subtype


    UniProtKB/Swiss-Prot: TAGL2_HUMAN, P37802
    Similarity: Belongs to the calponin family
    Similarity: Contains 1 calponin-like repeat
    Similarity: Contains 1 CH (calponin-homology) domain


    TAGLN2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for TAGLN2:
    transgelin 2,one of the earliest markers of differentiated smooth muscle cells and adult tissues,murine 2,Sm22
    alpha homolog

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    TAGLN2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TAGLN2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TAGLN2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TAGLN2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TAGLN2 

    miRNA
    Products:
        
    miRTarBase miRNAs that target TAGLN2:
    hsa-mir-1 (MIRT002788), hsa-mir-133a (MIRT005604)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TAGLN2
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate TAGLN2 (see all 13):
    hsa-miR-206 hsa-miR-3688-3p hsa-miR-4328 hsa-miR-147 hsa-miR-133b hsa-miR-1 hsa-miR-454* hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmidTAGLN2 3' UTR sequence
    Inhib. RNA
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of TAGLN2 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAGLN2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAGLN2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/36 Interacting proteins for TAGLN2 (P378021, 3 ENSP000003570754) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP1O947823, ENSP000003435264I2D: score=2 STRING: ENSP00000343526
    CDK2P249413, ENSP000002669704I2D: score=1 STRING: ENSP00000266970
    H2AFXP161043, ENSP000003643104I2D: score=1 STRING: ENSP00000364310
    PSMD6Q150083, ENSP000002959014I2D: score=1 STRING: ENSP00000295901
    ACTR6Q9GZN13, ENSP000001883124I2D: score=1 STRING: ENSP00000188312
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007517muscle organ development IEA--

    TAGLN2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TAGLN2 (TAGL2)

    Search CenterWatch for drugs/clinical trials and news about TAGLN2 / TAGL2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TAGLN2 gene (3 alternative transcripts): 
    NM_001277223.1  NM_001277224.1  NM_003564.2  

    Unigene Cluster for TAGLN2:

    Transgelin 2
    Hs.517168  [show with all ESTs]
    Unigene Representative Sequence: AY007127
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368096 ENST00000368097(uc001fun.1 uc010piy.1) ENST00000478033
    ENST00000320307 ENST00000397334
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TAGLN2
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate TAGLN2 (see all 13):
    hsa-miR-206 hsa-miR-3688-3p hsa-miR-4328 hsa-miR-147 hsa-miR-133b hsa-miR-1 hsa-miR-454* hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmidTAGLN2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TAGLN2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAGLN2
    Clone
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    OriGene ORF clones in mouse, rat for TAGLN2
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    GenScript: all cDNA clones in your preferred vector: TAGLN2 (NM_003564)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAGLN2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAGLN2
    Sirion Biotech Customized lentivirus for stable overexpression of TAGLN2 
                         Customized lentivirus expression plasmids for stable overexpression of TAGLN2 
    Primer
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    OriGene qPCR primer pairs and template standards for TAGLN2
    OriGene qSTAR qPCR primer pairs in human, mouse for TAGLN2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TAGLN2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAGLN2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAGLN2

    Additional mRNA sequence: 

    AJ844623.2 AJ844624.2 AK291562.1 AK298654.1 AY007127.1 BC002616.1 BC009357.2 CR542126.1 
    CR542136.1 D21261.1 GU727636.1 

    24/62 DOTS entries (see all 62):

    DT.75136829  DT.91777498  DT.95278374  DT.91777509  DT.100689339  DT.100689341  DT.100689358  DT.121405748 
    DT.121405845  DT.97846764  DT.95278792  DT.121405853  DT.92019602  DT.95278523  DT.100849499  DT.95278718 
    DT.100689338  DT.100689340  DT.100689327  DT.100689360  DT.121405920  DT.91777494  DT.92002510  DT.95278685 

    24/1765 AceView cDNA sequences (see all 1765):

    R72048 CR609748 AL547597 BQ962344 BM832133 AL544512 BF914953 BG424747 
    BE408544 BQ877154 CR607405 BP368128 BQ066807 BE743566 AA359323 BU196771 
    BM987932 BU527353 BF218499 AL551487 CA406210 BM917558 BU528246 BM695091 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TAGLN2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:              -                                                                                 
    SP2:                                                                                                
    SP3:                                                                                                


    ECgene alternative splicing isoforms for TAGLN2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TAGLN2 expression in normal human tissues (normalized intensities)      TAGLN2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTGGGGCT
    TAGLN2 Expression
    About this image


    TAGLN2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Adipose (Muscoskeletal System)
             Visceral White Adipose
     
     Intestine (Gastrointestinal Tract)
             visceral organ/gut/large intestine   
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Bone (Muscoskeletal System)
             Mandibular Condyle
     
     Endoderm (Gastrulation Derivatives)
             Definitive endoderm-like cells ( Generation of mesendoderm and definitive endoderm...

    See TAGLN2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TAGLN2

    SOURCE GeneReport for Unigene cluster: Hs.517168

    UniProtKB/Swiss-Prot: TAGL2_HUMAN, P37802
    Tissue specificity: Expressed in epididymis (at protein level)

        SABiosciences Custom PCR Arrays for TAGLN2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAGLN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TAGLN2 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tagln21 , 5 transgelin 21, 5 90.45(n)1
    96.48(a)1
      1 (79.89 cM)5
    213461  NM_178598.21  NP_848713.11 
     1725000475 
    chicken
    (Gallus gallus)
    Aves LOC1008572911 transgelin-2-like 76.21(n)
    80.81(a)
      100857291  XM_003643853.1  XP_003643901.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia tagln2-prov2 transgelin 2 81.32(n)    BC046722.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tagln1 transgelin 70.05(n)
    70.05(a)
      751758  NM_001045467.1  NP_001038932.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Chd643 actin binding 42(a)   64A7   --
    worm
    (Caenorhabditis elegans)
    Secernentea cpn-16
    cpn-26
    (see all 4)
    Protein CPN-2
    (see all 4)
    37(a)
    36(a)
    (see all 4)
    possible ortholog
    1 ↔ many
    (see all 4)
    I(8636120-8637961)
    II(337339-339248)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SCP1(YOR367W)4 Component of yeast cortical actin cytoskeleton, binds more   --   15(1026007-1026609) 854549  NP_015012.1 


    ENSEMBL Gene Tree for TAGLN2 (if available)
    TreeFam Gene Tree for TAGLN2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TAGLN2 gene
    TAGLN2  CNN12  CNN32  TAGLN32  CNN22  
    5 SIMAP similar genes for TAGLN2 using alignment to 2 protein entries:     TAGL2_HUMAN (see all proteins):
    TAGLN3    TAGLN    CNN1    CNN3    CNN2

    TAGLN2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TAGLN2
    PGOHUM00000249282 PGOHUM00000249475


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/198 SNPs in TAGLN2 are shown (see all 198)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1501921961,2
    --159887429(+) TCCACA/GTTTCC 3 -- ds50010--------
    rs1902194271,2
    --159887492(+) AGCCCA/GCCTGA 3 -- ds50010--------
    rs1142794681,2
    C,F--159887653(+) AGAAAG/AGGCCT 3 -- ds50011Minor allele frequency- A:0.03WA 118
    rs1494196191,2
    --159887678(+) CACTGC/GCTACA 3 -- ds50010--------
    rs1448475211,2
    --159887728(+) TCCAAC/TCTACA 3 -- ds50010--------
    rs1136335071,2
    F--159887865(+) CCCCAC/TAGTGG 3 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs10499741,2
    C--159887957(-) ATGGTC/TTGGGG 3 -- ut311Minor allele frequency- T:0.00NA 2
    rs1461326061,2
    --159888178(+) CTTGTA/GGAAGC 3 -- ut310--------
    rs1150703911,2
    C--159888253(+) GGACAC/TAGAGC 3 -- ut311Minor allele frequency- T:0.01WA 118
    rs1817518681,2
    --159888361(+) AGGAAA/GAGGCC 3 -- ut310--------

    HapMap Linkage Disequilibrium report for TAGLN2 (159887897 - 159895522 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TAGLN2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv516637CNV Loss19592680
    nsv872489CNV Loss21882294
    nsv524006CNV Gain19592680
    nsv464150CNV Gain19166990

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TAGLN2
    DNA2.0 Custom Variant and Variant Library Synthesis for TAGLN2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604634    OMIM disorders: --

    14 diseases for TAGLN2:    About MalaCards
    neural tube defects    epididymitis    peritonitis    endometriosis
    acute myeloid leukemia    myeloid leukemia    hypoxia    neuroblastoma
    hepatitis b    hepatocellular carcinoma    leukemia    squamous cell carcinoma
    hepatitis    neuronitis


    TAGLN2 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for TAGLN2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    neural tube defects 49.2 1 11990753 (1)


    Export disorders for TAGLN2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TAGLN2 gene, integrated from 9 sources (see all 68):
    (articles sorted by number of sources associating them with TAGLN2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PubMed id 20736409)1, 2 Li J.... Liu Y. (2010)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    5. Paralogous sm22alpha (Tagln) genes map to mouse chromosomes 1 and 9: further evidence for a paralogous relationship. (PubMed id 9693045)1, 3 Stanier P....Copp A.J. (1998)
    6. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527)1, 2 Nagase T....Kotani H. (1995)
    7. Tissue proteomics reveals differential and compartmen t-specific expression of the homologs transgelin and transgelin-2 in lung adeno carcinoma and its stroma. (PubMed id 19848416)1, 9 Rho J.H....Wang J.Y. (2009)
    8. Proteomic analysis of differential protein expression by brain metastases of gynecological malignancies. (PubMed id 23504277)1 Yoshida A....Suzuki N. (2013)
    9. Clinical significance of pituitary tumor transforming gene 1 and transgelin-2 in pancreatic cancer. (PubMed id 23527717)1 Lin H....Su L.D. (2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8407 HGNC: 11554 AceView: TAGLN2andNESG1andIGSF9 Ensembl:ENSG00000158710 euGenes: HUgn8407
    ECgene: TAGLN2 H-InvDB: TAGLN2

    (According to HUGE)
    About This Section
    HUGE: KIAA0120

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TAGLN2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TAGLN2 gene:
    Search GeneIP for patents involving TAGLN2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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