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Aliases & Descriptions for TAGLN2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| HA1756 1, 2 | | KIAA0120 1, 2, 3 | | OTTHUMP00000024407 2 | | OTTHUMP00000024409 2 |
| | | Descriptions |
|---|
| SM22-alpha homolog 2, 3 | | transgelin 2 2 |
|
| | Search outside databases for aliases for TAGLN2 genePrevious GC identifers: GC01M157680 GC01M155620 GC01M156665 GC01M157104 GC01M156700 GC01M158108 |
Summaries for TAGLN2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for TAGLN2: The protein encoded by this gene is a homolog of the protein transgelin, which is one of the earliest markers of differentiated smooth muscle. The function of this protein has not yet been determined. [provided by RefSeq] Gene Wiki entry for TAGLN2 |
Genomic Location for TAGLN2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the TAGLN2 gene 
Entrez Gene cytogenetic band: 1q21-q25 Ensembl cytogenetic band: 1q23.2 HGNC cytogenetic band: 1q21-q25TAGLN2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M158154:
(about GC identifiers)
Start:
|
158,154,521 bp from pter |
End:
|
158,161,908 bp from pter |
Size:
|
7,388 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000001.9 NT_004487.18
| Proteins for TAGLN2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: TAGL2_HUMAN, P37802 (See
protein sequence)Recommended Name: Transgelin-2 Size: 199 amino acids; 22391 Da
PDB structures from and Proteopedia :1WYM (3D)
 
Secondary accessions: Q5JRQ6 Q5JRQ7 Q6FGI1 Q9BUH5 Q9H4P0Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_003555.1
ENSEMBL proteins: ENSP00000357076 ENSP00000357077 ENSP00000357075
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: TAGLN2 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for TAGLN2: Assays for TAGLN2: | Protein
Domains/ Families for TAGLN2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P37802
ProtoNet protein and cluster: P37802 3 Blocks protein families: IPB001061 Smooth muscle protein 22-alpha (transgelin) signature IPB001715 Calponin-like actin-binding IPB003247 Calponin-like actin-binding subtype
UniProtKB/Swiss-Prot: TAGL2_HUMAN, P37802Similarity: Belongs to the calponin familySimilarity: Contains 1 calponin-like repeatSimilarity: Contains 1 CH (calponin-homology) domain | Gene Function for TAGLN2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003564
Applied Biosystems Silencer® siRNAs for TAGLN2
Sigma-Aldrich siRNA for TAGLN2  Sigma-Aldrich shRNA for TAGLN2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003564                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003564                                  untagged cDNA clone in CMV expression vector: NM_003564 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_003564
Genatlas biochemistry entry for TAGLN2:transgelin 2,one of the earliest markers of differentiated smooth muscle cells and adult tissues,murine 2,Sm22 alpha homolog1 Gene Ontology (GO) molecular function term (links to tree view): About this table | Pathways & Interactions for TAGLN2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
3 Interacting proteins for TAGLN2 (P378021) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007517 | muscle development |
IEA | -- | About this table
|
Drugs & Compounds for TAGLN2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for TAGLN2
|
Transcripts for TAGLN2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003564
Sigma-Aldrich siRNA for TAGLN2  Sigma-Aldrich shRNA for TAGLN2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_003564 REFSEQ mRNAs for TAGLN2 gene: NM_003564.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_003564               OriGene GFP tagged cDNA clone in CMV expression vector: NM_003564                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_003564                                  untagged cDNA clone in CMV expression vector: NM_003564  Additional cDNA sequence: AJ844623.2 AJ844624.2 AK291562.1 AK298654.1 AY007127.1 BC002616.1 BC009357.2 CR542126.1 CR542136.1 CR590131.1 CR590142.1 CR591926.1 CR592747.1 CR592851.1 CR594260.1 CR599010.1 CR601283.1 CR602105.1 CR603278.1 CR604118.1 CR604476.1 CR606060.1 CR607405.1 CR607855.1 CR608199.1 CR608276.1 CR608575.1 CR609407.1 CR609748.1 CR609777.1 CR610006.1 CR611080.1 CR611788.1 CR612553.1 CR613098.1 CR613520.1 CR614100.1 CR616442.1 CR617101.1 CR618095.1 CR618563.1 CR618634.1 CR620277.1 CR620855.1 CR621323.1 CR621369.1 CR621718.1 CR621820.1 CR622397.1 CR623124.1 CR623657.1 CR624026.1 CR624984.1 CR625445.1 CR626596.1 D21261.1 24/62 DOTS entries (see all 62
): DT.75136829 DT.91777498 DT.95278374 DT.91777509 DT.100689339 DT.100689341 DT.100689358 DT.121405748 DT.121405845 DT.97846764 DT.95278792 DT.121405853 DT.92019602 DT.95278523 DT.100849499 DT.95278718 DT.92002510 DT.100689338 DT.100689340 DT.100689327 DT.100689360 DT.121405920 DT.91777494 DT.95278685 24/1765 AceView cDNA sequences (see all 1765
):BM915429 BU751876 BM049354 AI696411 BG424460 BM829749 BU164676 CB306374 CF128526 BE273877 BM849199 BQ935711 CR609748 CR622397 CR623657 BP340014 BX332839 BP340453 BM917558 CR607405 CR617101 BG285162 BM043982 BQ707593
highest scoring ESTs for TAGLN2:D21261 BC002616 BC009357 BI226169 BI861515 AA248323 AA459529 AA513797 AA584234 AA604533 Unigene Cluster for TAGLN2: Transgelin 2 Hs.517168 [show with all ESTs]Unigene Representative Sequence: CR620277
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for TAGLN2
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | |
| SP1: | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for TAGLN2
3 Ensembl transcripts including schematic representations: ENST00000368096
ENST00000368097
ENST00000320307
|
Expression for TAGLN2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| TAGLN2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for TAGLN2
1 / 2 / 3 5 probe-sets matching TAGLN2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GTCTGGGGCT
SOURCE GeneReport for Unigene cluster: Hs.517168
Expression variation in blood from EXPOLDB for TAGLN2 |
Orthologs for TAGLN2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TAGLN2 gene from 5/11 species (see all 11
)
About this table Species with no ortholog for TAGLN2
ENSEMBL Gene Tree for TAGLN2 | Paralogs for TAGLN2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for TAGLN2 gene
- TAGLN2 TAGLN32
Pseudogenes
- 2 related pseudogenes
|
SNPs/Variants for TAGLN2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for TAGLN2 (up to first 250kb)
|
Disorders & Mutations for TAGLN2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 604634
1 Novoseek disease relationship for TAGLN2 gene
About this table
|
Medical News for TAGLN2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for TAGLN2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/31 PubMed articles for TAGLN2 gene (see all 31
): |
Search for TAGLN2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TAGLN2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing TAGLN2
(According to HUGE)
About This Section
| |
Specialized Databases showing TAGLN2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for TAGLN2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for TAGLN2:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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