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Aliases for TAGLN2 Gene

Aliases for TAGLN2 Gene

  • Transgelin 2 2 3 5
  • SM22-Alpha Homolog 2 3 4
  • Epididymis Tissue Protein Li 7e 3 4
  • KIAA0120 4
  • HA1756 3

External Ids for TAGLN2 Gene

Previous GeneCards Identifiers for TAGLN2 Gene

  • GC01M157680
  • GC01M155620
  • GC01M156665
  • GC01M157104
  • GC01M156700
  • GC01M158108
  • GC01M158154
  • GC01M159887
  • GC01M131244

Summaries for TAGLN2 Gene

Entrez Gene Summary for TAGLN2 Gene

  • The protein encoded by this gene is similar to the protein transgelin, which is one of the earliest markers of differentiated smooth muscle. The specific function of this protein has not yet been determined, although it is thought to be a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]

GeneCards Summary for TAGLN2 Gene

TAGLN2 (Transgelin 2) is a Protein Coding gene. GO annotations related to this gene include actin filament binding. An important paralog of this gene is CNN3.

Gene Wiki entry for TAGLN2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAGLN2 Gene

Genomics for TAGLN2 Gene

Regulatory Elements for TAGLN2 Gene

Promoters for TAGLN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TAGLN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAGLN2 Gene

Chromosome:
1
Start:
159,918,107 bp from pter
End:
159,925,732 bp from pter
Size:
7,626 bases
Orientation:
Minus strand

Genomic View for TAGLN2 Gene

Genes around TAGLN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAGLN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAGLN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAGLN2 Gene

Proteins for TAGLN2 Gene

  • Protein details for TAGLN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P37802-TAGL2_HUMAN
    Recommended name:
    Transgelin-2
    Protein Accession:
    P37802
    Secondary Accessions:
    • E9KL39
    • Q5JRQ6
    • Q5JRQ7
    • Q6FGI1
    • Q9BUH5
    • Q9H4P0

    Protein attributes for TAGLN2 Gene

    Size:
    199 amino acids
    Molecular mass:
    22391 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA04802.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI14604.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TAGLN2 Gene

    Alternative splice isoforms for TAGLN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAGLN2 Gene

Proteomics data for TAGLN2 Gene at MOPED

Post-translational modifications for TAGLN2 Gene

  • Ubiquitination at Lys 79 and Lys 120
  • Modification sites at PhosphoSitePlus

Other Protein References for TAGLN2 Gene

Antibody Products

No data available for DME Specific Peptides for TAGLN2 Gene

Domains & Families for TAGLN2 Gene

Suggested Antigen Peptide Sequences for TAGLN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P37802

UniProtKB/Swiss-Prot:

TAGL2_HUMAN :
  • Contains 1 CH (calponin-homology) domain.
  • Belongs to the calponin family.
  • Contains 1 calponin-like repeat.
Domain:
  • Contains 1 CH (calponin-homology) domain.
Family:
  • Belongs to the calponin family.
Similarity:
  • Contains 1 calponin-like repeat.
genes like me logo Genes that share domains with TAGLN2: view

No data available for Gene Families for TAGLN2 Gene

Function for TAGLN2 Gene

Molecular function for TAGLN2 Gene

GENATLAS Biochemistry:
transgelin 2,one of the earliest markers of differentiated smooth muscle cells and adult tissues,murine 2,Sm22 alpha homolog
genes like me logo Genes that share phenotypes with TAGLN2: view

Animal Model Products

miRNA for TAGLN2 Gene

miRTarBase miRNAs that target TAGLN2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAGLN2 Gene

Localization for TAGLN2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAGLN2 Gene COMPARTMENTS Subcellular localization image for TAGLN2 gene
Compartment Confidence
extracellular 5
cytosol 4
cytoskeleton 3
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TAGLN2 Gene

Pathways & Interactions for TAGLN2 Gene

SuperPathways for TAGLN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TAGLN2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TAGLN2 Gene

Drugs & Compounds for TAGLN2 Gene

No Compound Related Data Available

Transcripts for TAGLN2 Gene

Unigene Clusters for TAGLN2 Gene

Transgelin 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAGLN2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2:
SP3:

Relevant External Links for TAGLN2 Gene

GeneLoc Exon Structure for
TAGLN2
ECgene alternative splicing isoforms for
TAGLN2

Expression for TAGLN2 Gene

mRNA expression in normal human tissues for TAGLN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TAGLN2 Gene

This gene is overexpressed in Whole Blood (x10.5).

Protein differential expression in normal tissues from HIPED for TAGLN2 Gene

This gene is overexpressed in Platelet (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAGLN2 Gene



SOURCE GeneReport for Unigene cluster for TAGLN2 Gene Hs.517168

mRNA Expression by UniProt/SwissProt for TAGLN2 Gene

P37802-TAGL2_HUMAN
Tissue specificity: Expressed in epididymis (at protein level).
genes like me logo Genes that share expression patterns with TAGLN2: view

Protein tissue co-expression partners for TAGLN2 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for TAGLN2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAGLN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAGLN2 35
  • 99.39 (n)
  • 100 (a)
TAGLN2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAGLN2 36
  • 99 (a)
OneToOne
TAGLN2 35
  • 93.63 (n)
  • 98.99 (a)
dog
(Canis familiaris)
Mammalia TAGLN2 35
  • 92.63 (n)
  • 99.5 (a)
TAGLN2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tagln2 36
  • 96 (a)
OneToOne
Tagln2 16
Tagln2 35
  • 90.62 (n)
  • 96.48 (a)
oppossum
(Monodelphis domestica)
Mammalia TAGLN2 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAGLN2 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tagln2 35
  • 91.29 (n)
  • 96.98 (a)
chicken
(Gallus gallus)
Aves TAGLN2 36
  • 52 (a)
OneToOne
LOC100857291 35
  • 76.38 (n)
  • 80.81 (a)
African clawed frog
(Xenopus laevis)
Amphibia tagln2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75598 35
tagln2 35
  • 69.56 (n)
  • 70.41 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11293 35
zebrafish
(Danio rerio)
Actinopterygii cnn3a 36
  • 25 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Chd64 37
  • 42 (a)
Mp20 36
  • 37 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea cpn-2 36
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCP1 36
  • 27 (a)
OneToMany
SCP1 38
SCP1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
ManyToMany
CSA.10356 36
  • 41 (a)
ManyToMany
Species with no ortholog for TAGLN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAGLN2 Gene

ENSEMBL:
Gene Tree for TAGLN2 (if available)
TreeFam:
Gene Tree for TAGLN2 (if available)

Paralogs for TAGLN2 Gene

Paralogs for TAGLN2 Gene

(5) SIMAP similar genes for TAGLN2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TAGLN2 Gene

genes like me logo Genes that share paralogs with TAGLN2: view

Variants for TAGLN2 Gene

Sequence variations from dbSNP and Humsavar for TAGLN2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs17849636 - 159,919,810(+) GGTAC(A/T)GTGCA reference, missense
rs1049905 -- 159,918,278(-) CACAT(C/T)TGGGG utr-variant-3-prime
rs1934075 -- 159,926,189(-) TTTCT(C/T)CACCC upstream-variant-2KB
rs2252815 -- 159,919,896(-) TGGTG(C/T)ACGCT intron-variant
rs2185211 -- 159,924,046(-) TCCTG(A/C)GTCCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TAGLN2 Gene

Variant ID Type Subtype PubMed ID
nsv872489 CNV Loss 21882294
nsv464150 CNV Gain 19166990
nsv524006 CNV Gain 19592680
nsv516637 CNV Loss 19592680

Variation tolerance for TAGLN2 Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.28; 53.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAGLN2 Gene

HapMap Linkage Disequilibrium report
TAGLN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAGLN2 Gene

Disorders for TAGLN2 Gene

Relevant External Links for TAGLN2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAGLN2

No disorders were found for TAGLN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAGLN2 Gene

Publications for TAGLN2 Gene

  1. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PMID: 20736409) Li J. … Liu Y. (Mol. Cell. Proteomics 2010) 3 4 67
  2. Tissue proteomics reveals differential and compartment-specific expression of the homologs transgelin and transgelin-2 in lung adenocarcinoma and its stroma. (PMID: 19848416) Rho J.H. … Wang J.Y. (J. Proteome Res. 2009) 3 23
  3. Paralogous sm22alpha (Tagln) genes map to mouse chromosomes 1 and 9: further evidence for a paralogous relationship. (PMID: 9693045) Stanier P. … Copp A.J. (Genomics 1998) 2 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. miR-133a mediates the hypoxia-induced apoptosis by inhibiting TAGLN2 expression in cardiac myocytes. (PMID: 25421410) Li A.Y. … Yang K. (Mol. Cell. Biochem. 2015) 3

Products for TAGLN2 Gene

Sources for TAGLN2 Gene

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