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Aliases for TAGLN2 Gene

Aliases for TAGLN2 Gene

  • Transgelin 2 2 3 5
  • SM22-Alpha Homolog 2 3 4
  • Epididymis Tissue Protein Li 7e 3 4
  • Transgelin-2 3
  • KIAA0120 4
  • HA1756 3

External Ids for TAGLN2 Gene

Previous GeneCards Identifiers for TAGLN2 Gene

  • GC01M157680
  • GC01M155620
  • GC01M156665
  • GC01M157104
  • GC01M156700
  • GC01M158108
  • GC01M158154
  • GC01M159887
  • GC01M131244

Summaries for TAGLN2 Gene

Entrez Gene Summary for TAGLN2 Gene

  • The protein encoded by this gene is similar to the protein transgelin, which is one of the earliest markers of differentiated smooth muscle. The specific function of this protein has not yet been determined, although it is thought to be a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]

GeneCards Summary for TAGLN2 Gene

TAGLN2 (Transgelin 2) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+. GO annotations related to this gene include actin filament binding. An important paralog of this gene is TAGLN3.

Gene Wiki entry for TAGLN2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAGLN2 Gene

Genomics for TAGLN2 Gene

Regulatory Elements for TAGLN2 Gene

Enhancers for TAGLN2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G159908 2.1 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +8.2 8249 18.5 FEZF1 YBX1 YY1 ZNF143 ZNF263 SP3 TBX21 MEF2D ZNF610 GLIS1 SNHG28 ENSG00000272668 RPSAP18 ENSG00000228606 VSIG8 PIGM SLAMF8 CADM3 TAGLN2 FCRL6
GH01G159888 1.9 FANTOM5 Ensembl ENCODE dbSUPER 2.8 +35.2 35249 3.0 HDGF ATF1 SIN3A ZNF2 GLIS2 GATA2 ZNF207 ZNF143 FOS DEK ENSG00000272668 SLAMF8 SNHG28 FCRL6 VSIG8 ENSG00000212161 IGSF9 DUSP23 PIGM SLAMF9
GH01G159881 1.8 FANTOM5 Ensembl ENCODE dbSUPER 2 +43.6 43597 1.7 PKNOX1 SIN3A FOS DEK ZNF491 ZNF518A ZNF592 MAFF SMARCA4 GLIS1 ENSG00000272668 RPSAP18 SNHG28 ENSG00000228606 SLAMF8 PIGM CADM3 VSIG8 SLAMF9 TAGLN2
GH01G160346 1.3 FANTOM5 Ensembl ENCODE 2.5 -421.2 -421169 1.8 HDGF MXI1 USF1 MAX ARID4B ZNF384 EBF1 ZBTB40 ARID3A RELB NCSTN IGSF8 COPA TAGLN2 CD48 SLAMF7 GC01P160354
GH01G159848 1.4 FANTOM5 Ensembl ENCODE dbSUPER 1.3 +76.2 76205 1.9 ZNF589 HLF CEBPB FOS ZNF24 ENSG00000272668 SLAMF9 SLAMF8 TAGLN2 GC01M159852 GC01M159841 ENSG00000212161
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAGLN2 on UCSC Golden Path with GeneCards custom track

Promoters for TAGLN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000014472 1032 2601 HDGF PKNOX1 FOXA2 WRNIP1 SIN3A FEZF1 YBX1 ZNF2 ZNF143 ZNF207

Genomic Location for TAGLN2 Gene

Chromosome:
1
Start:
159,918,107 bp from pter
End:
159,925,732 bp from pter
Size:
7,626 bases
Orientation:
Minus strand

Genomic View for TAGLN2 Gene

Genes around TAGLN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAGLN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAGLN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAGLN2 Gene

Proteins for TAGLN2 Gene

  • Protein details for TAGLN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P37802-TAGL2_HUMAN
    Recommended name:
    Transgelin-2
    Protein Accession:
    P37802
    Secondary Accessions:
    • E9KL39
    • Q5JRQ6
    • Q5JRQ7
    • Q6FGI1
    • Q9BUH5
    • Q9H4P0

    Protein attributes for TAGLN2 Gene

    Size:
    199 amino acids
    Molecular mass:
    22391 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA04802.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI14604.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TAGLN2 Gene

    Alternative splice isoforms for TAGLN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAGLN2 Gene

Post-translational modifications for TAGLN2 Gene

  • Ubiquitination at posLast=7979 and Lys120
  • Modification sites at PhosphoSitePlus

Other Protein References for TAGLN2 Gene

No data available for DME Specific Peptides for TAGLN2 Gene

Domains & Families for TAGLN2 Gene

Suggested Antigen Peptide Sequences for TAGLN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P37802

UniProtKB/Swiss-Prot:

TAGL2_HUMAN :
  • Belongs to the calponin family.
Family:
  • Belongs to the calponin family.
genes like me logo Genes that share domains with TAGLN2: view

No data available for Gene Families for TAGLN2 Gene

Function for TAGLN2 Gene

Molecular function for TAGLN2 Gene

GENATLAS Biochemistry:
transgelin 2,one of the earliest markers of differentiated smooth muscle cells and adult tissues,murine 2,Sm22 alpha homolog

Gene Ontology (GO) - Molecular Function for TAGLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21577206
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with TAGLN2: view
genes like me logo Genes that share phenotypes with TAGLN2: view

Animal Model Products

miRNA for TAGLN2 Gene

miRTarBase miRNAs that target TAGLN2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAGLN2 Gene

Localization for TAGLN2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAGLN2 gene
Compartment Confidence
extracellular 5
cytosol 5
cytoskeleton 3
nucleus 2

Gene Ontology (GO) - Cellular Components for TAGLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005829 cytosol TAS --
GO:0031982 vesicle IDA 19190083
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TAGLN2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TAGLN2 Gene

Pathways & Interactions for TAGLN2 Gene

genes like me logo Genes that share pathways with TAGLN2: view

Gene Ontology (GO) - Biological Process for TAGLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0030855 epithelial cell differentiation IDA 21492153
genes like me logo Genes that share ontologies with TAGLN2: view

No data available for SIGNOR curated interactions for TAGLN2 Gene

Drugs & Compounds for TAGLN2 Gene

No Compound Related Data Available

Transcripts for TAGLN2 Gene

Unigene Clusters for TAGLN2 Gene

Transgelin 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAGLN2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2:
SP3:

Relevant External Links for TAGLN2 Gene

GeneLoc Exon Structure for
TAGLN2
ECgene alternative splicing isoforms for
TAGLN2

Expression for TAGLN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAGLN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TAGLN2 Gene

This gene is overexpressed in Whole Blood (x10.5).

Protein differential expression in normal tissues from HIPED for TAGLN2 Gene

This gene is overexpressed in Platelet (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TAGLN2 Gene



Protein tissue co-expression partners for TAGLN2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TAGLN2 Gene:

TAGLN2

SOURCE GeneReport for Unigene cluster for TAGLN2 Gene:

Hs.517168

mRNA Expression by UniProt/SwissProt for TAGLN2 Gene:

P37802-TAGL2_HUMAN
Tissue specificity: Expressed in epididymis (at protein level).

Evidence on tissue expression from TISSUES for TAGLN2 Gene

  • Blood(4.6)
  • Bone marrow(4.4)
  • Skin(4.4)
  • Liver(4.3)
  • Lung(4.2)
  • Nervous system(4.1)
  • Pancreas(3.8)
  • Intestine(3.2)
  • Eye(2.9)
  • Kidney(2.7)
  • Lymph node(2.6)
  • Stomach(2.3)
  • Spleen(2.2)
  • Gall bladder(2.1)
genes like me logo Genes that share expression patterns with TAGLN2: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TAGLN2 Gene

Orthologs for TAGLN2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAGLN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAGLN2 34 35
  • 99.39 (n)
oppossum
(Monodelphis domestica)
Mammalia TAGLN2 35
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAGLN2 34 35
  • 93.63 (n)
dog
(Canis familiaris)
Mammalia TAGLN2 34 35
  • 92.63 (n)
rat
(Rattus norvegicus)
Mammalia Tagln2 34
  • 91.29 (n)
mouse
(Mus musculus)
Mammalia Tagln2 34 16 35
  • 90.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TAGLN2 35
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857291 34
  • 76.38 (n)
TAGLN2 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tagln2 34
  • 69.56 (n)
MGC75598 34
African clawed frog
(Xenopus laevis)
Amphibia tagln2-prov 34
zebrafish
(Danio rerio)
Actinopterygii cnn3a 35
  • 25 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11293 34
fruit fly
(Drosophila melanogaster)
Insecta Chd64 36
  • 42 (a)
Mp20 35
  • 37 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea cpn-2 35
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCP1 35 37 37
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 42 (a)
ManyToMany
CSA.10356 35
  • 41 (a)
ManyToMany
Species where no ortholog for TAGLN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAGLN2 Gene

ENSEMBL:
Gene Tree for TAGLN2 (if available)
TreeFam:
Gene Tree for TAGLN2 (if available)

Paralogs for TAGLN2 Gene

Paralogs for TAGLN2 Gene

(5) SIMAP similar genes for TAGLN2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TAGLN2 Gene

genes like me logo Genes that share paralogs with TAGLN2: view

Variants for TAGLN2 Gene

Sequence variations from dbSNP and Humsavar for TAGLN2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000474536 -- 159,921,560(+) CTGTA(A/C)GATGC intron-variant
rs1000695898 -- 159,917,796(+) AGCTG(C/T)TCCAA downstream-variant-500B
rs1000891252 -- 159,924,596(+) CGCCG(-/C)CCCCC intron-variant, upstream-variant-2KB
rs1001755834 -- 159,920,958(+) GATTG(C/T)ACACA intron-variant
rs1001856821 -- 159,926,129(+) AGCGC(A/G)AGGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TAGLN2 Gene

Variant ID Type Subtype PubMed ID
nsv1005195 CNV gain 25217958
nsv464150 CNV gain 19166990
nsv516637 CNV loss 19592680
nsv524006 CNV gain 19592680
nsv548052 CNV gain 21841781
nsv548053 CNV loss 21841781
nsv946451 CNV duplication 23825009

Variation tolerance for TAGLN2 Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.28; 53.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAGLN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAGLN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAGLN2 Gene

Disorders for TAGLN2 Gene

Relevant External Links for TAGLN2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAGLN2

No disorders were found for TAGLN2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAGLN2 Gene

Publications for TAGLN2 Gene

  1. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PMID: 20736409) Li J. … Liu Y. (Mol. Cell. Proteomics 2010) 3 4 64
  2. Tissue proteomics reveals differential and compartment-specific expression of the homologs transgelin and transgelin-2 in lung adenocarcinoma and its stroma. (PMID: 19848416) Rho J.H. … Wang J.Y. (J. Proteome Res. 2009) 3 22 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K. … Vandekerckhove J. (Nat. Biotechnol. 2003) 3 4 64

Products for TAGLN2 Gene

Sources for TAGLN2 Gene

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