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Aliases for TAGLN2 Gene

Aliases for TAGLN2 Gene

  • Transgelin 2 2 3
  • SM22-Alpha Homolog 2 3 4
  • Epididymis Tissue Protein Li 7e 3 4
  • Transgelin-2 3
  • KIAA0120 4
  • HA1756 3

External Ids for TAGLN2 Gene

Previous GeneCards Identifiers for TAGLN2 Gene

  • GC01M157680
  • GC01M155620
  • GC01M156665
  • GC01M157104
  • GC01M156700
  • GC01M158108
  • GC01M158154
  • GC01M159887
  • GC01M131244

Summaries for TAGLN2 Gene

Entrez Gene Summary for TAGLN2 Gene

  • The protein encoded by this gene is similar to the protein transgelin, which is one of the earliest markers of differentiated smooth muscle. The specific function of this protein has not yet been determined, although it is thought to be a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]

GeneCards Summary for TAGLN2 Gene

TAGLN2 (Transgelin 2) is a Protein Coding gene. Diseases associated with TAGLN2 include neural tube defects. An important paralog of this gene is CNN3.

Gene Wiki entry for TAGLN2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAGLN2 Gene

Genomics for TAGLN2 Gene

Regulatory Elements for TAGLN2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TAGLN2 Gene

159,918,107 bp from pter
159,925,732 bp from pter
7,626 bases
Minus strand

Genomic View for TAGLN2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAGLN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAGLN2 Gene

Proteins for TAGLN2 Gene

  • Protein details for TAGLN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • E9KL39
    • Q5JRQ6
    • Q5JRQ7
    • Q6FGI1
    • Q9BUH5
    • Q9H4P0

    Protein attributes for TAGLN2 Gene

    199 amino acids
    Molecular mass:
    22391 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA04802.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI14604.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TAGLN2 Gene

    Alternative splice isoforms for TAGLN2 Gene


neXtProt entry for TAGLN2 Gene

Proteomics data for TAGLN2 Gene at MOPED

Post-translational modifications for TAGLN2 Gene

  • Ubiquitination at Lys79, Lys120, and Lys171
  • Modification sites at PhosphoSitePlus

Other Protein References for TAGLN2 Gene

Antibody Products

No data available for DME Specific Peptides for TAGLN2 Gene

Domains for TAGLN2 Gene

Suggested Antigen Peptide Sequences for TAGLN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P37802
  • Contains 1 CH (calponin-homology) domain.
  • Belongs to the calponin family.
  • Contains 1 calponin-like repeat.
genes like me logo Genes that share domains with TAGLN2: view

No data available for Gene Families for TAGLN2 Gene

Function for TAGLN2 Gene

Molecular function for TAGLN2 Gene

GENATLAS Biochemistry:
transgelin 2,one of the earliest markers of differentiated smooth muscle cells and adult tissues,murine 2,Sm22 alpha homolog

Gene Ontology (GO) - Molecular Function for TAGLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21577206
GO:0051015 actin filament binding IEA --
genes like me logo Genes that share ontologies with TAGLN2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TAGLN2 Gene

Localization for TAGLN2 Gene

Subcellular locations from

Jensen Localization Image for TAGLN2 Gene COMPARTMENTS Subcellular localization image for TAGLN2 gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for TAGLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031982 vesicle IDA 19190083
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TAGLN2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TAGLN2 Gene

Pathways for TAGLN2 Gene

SuperPathways for TAGLN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TAGLN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030855 epithelial cell differentiation IDA 21492153
genes like me logo Genes that share ontologies with TAGLN2: view

No data available for Pathways by source for TAGLN2 Gene

Transcripts for TAGLN2 Gene

Unigene Clusters for TAGLN2 Gene

Transgelin 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAGLN2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAGLN2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: -

Relevant External Links for TAGLN2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TAGLN2 Gene

mRNA expression in normal human tissues for TAGLN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TAGLN2 Gene

This gene is overexpressed in Whole Blood (10.5).

Protein differential expression in normal tissues for TAGLN2 Gene

This gene is overexpressed in Platelet (10.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAGLN2 Gene

SOURCE GeneReport for Unigene cluster for TAGLN2 Gene Hs.517168

mRNA Expression by UniProt/SwissProt for TAGLN2 Gene

Tissue specificity: Expressed in epididymis (at protein level).
genes like me logo Genes that share expressions with TAGLN2: view

Expression partners for TAGLN2 Gene

In Situ Assay Products

Orthologs for TAGLN2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAGLN2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TAGLN2 35
  • 93.63 (n)
  • 98.99 (a)
  • 99 (a)
(Canis familiaris)
Mammalia TAGLN2 35
  • 92.63 (n)
  • 99.5 (a)
  • 99 (a)
(Mus musculus)
Mammalia Tagln2 35
  • 90.62 (n)
  • 96.48 (a)
Tagln2 16
Tagln2 36
  • 96 (a)
(Pan troglodytes)
Mammalia TAGLN2 35
  • 99.39 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Tagln2 35
  • 91.29 (n)
  • 96.98 (a)
(Monodelphis domestica)
Mammalia TAGLN2 36
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia TAGLN2 36
  • 80 (a)
(Gallus gallus)
Aves LOC100857291 35
  • 76.38 (n)
  • 80.81 (a)
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75598 35
tagln2 35
  • 69.56 (n)
  • 70.41 (a)
African clawed frog
(Xenopus laevis)
Amphibia tagln2-prov 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11293 35
(Danio rerio)
Actinopterygii cnn3a 36
  • 25 (a)
fruit fly
(Drosophila melanogaster)
Insecta Chd64 37
  • 42 (a)
Mp20 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea cpn-2 36
  • 38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCP1 36
  • 27 (a)
SCP1 38
SCP1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
CSA.10356 36
  • 41 (a)
Species with no ortholog for TAGLN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAGLN2 Gene

Gene Tree for TAGLN2 (if available)
Gene Tree for TAGLN2 (if available)

Paralogs for TAGLN2 Gene

Paralogs for TAGLN2 Gene

Selected SIMAP similar genes for TAGLN2 Gene using alignment to 2 proteins: Pseudogenes for TAGLN2 Gene

genes like me logo Genes that share paralogs with TAGLN2: view

Variants for TAGLN2 Gene

Sequence variations from dbSNP and Humsavar for TAGLN2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1049905 -- 159,918,278(-) CACAT(C/T)TGGGG utr-variant-3-prime
rs1049974 -- 159,918,167(-) ATGGT(C/T)TGGGG utr-variant-3-prime
rs1317846 -- 159,925,169(-) CCATC(G/T)CTGAG upstream-variant-2KB, intron-variant
rs1317847 -- 159,925,056(-) GCTTT(C/T)CCGCG upstream-variant-2KB, intron-variant
rs1934075 -- 159,926,189(-) TTTCT(C/T)CACCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TAGLN2 Gene

Variant ID Type Subtype PubMed ID
nsv872489 CNV Loss 21882294
nsv464150 CNV Gain 19166990
nsv524006 CNV Gain 19592680
nsv516637 CNV Loss 19592680

Relevant External Links for TAGLN2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAGLN2 Gene

Disorders for TAGLN2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TAGLN2 Gene in MalaCards »

(1) Diseases for TAGLN2 Gene including...

(1) Novoseek inferred disease relationships for TAGLN2 Gene

Disease -log(P) Hits PubMed IDs
neural tube defects 49.2 1
genes like me logo Genes that share disorders with TAGLN2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Genatlas and External Links for TAGLN2 Gene

Publications for TAGLN2 Gene

  1. Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins. (PMID: 20736409) Li J. … Liu Y. (Mol. Cell. Proteomics 2010) 3 4
  2. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7788527) Nagase T. … Nomura N. (DNA Res. 1995) 3 4
  3. Tissue proteomics reveals differential and compartment-specific expression of the homologs transgelin and transgelin-2 in lung adenocarcinoma and its stroma. (PMID: 19848416) Rho J.H. … Wang J.Y. (J. Proteome Res. 2009) 3 23
  4. Paralogous sm22alpha (Tagln) genes map to mouse chromosomes 1 and 9: further evidence for a paralogous relationship. (PMID: 9693045) Stanier P. … Copp A.J. (Genomics 1998) 2 3
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for TAGLN2 Gene

Sources for TAGLN2 Gene

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