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TAGLN2 Gene

protein-coding   GIFtS: 59

GC01M158154
transgelin 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
HA1756 1, 2
KIAA0120 1, 2, 3
OTTHUMP00000024407 2
OTTHUMP00000024409 2
Descriptions
SM22-alpha homolog 2, 3
transgelin 2 2
External Ids
HGNC: 115541
Entrez Gene: 84072
UniProtKB: P378023
Ensembl: ENSG000001587107
Search outside databases for aliases for TAGLN2 gene

Previous GC identifers: GC01M157680 GC01M155620 GC01M156665 GC01M157104 GC01M156700 GC01M158108

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TAGLN2:
The protein encoded by this gene is a homolog of the protein transgelin, which is one of the
earliest markers of differentiated smooth muscle. The function of this protein has not yet been
determined. [provided by RefSeq]

Gene Wiki entry for TAGLN2
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the TAGLN2 gene  

Entrez Gene cytogenetic band: 1q21-q25   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q21-q25

TAGLN2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M158154:     (about GC identifiers)

Start:
158,154,521 bp from pter
End:
158,161,908 bp from pter
Size:
7,388 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000001.9  NT_004487.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TAGL2_HUMAN, P37802 (See protein sequence)
Recommended Name: Transgelin-2  
Size: 199 amino acids; 22391 Da
PDB structures from and Proteopedia :
1WYM (3D)    
Secondary accessions: Q5JRQ6 Q5JRQ7 Q6FGI1 Q9BUH5 Q9H4P0

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_003555.1  

    ENSEMBL proteins: 
    ENSP00000357076 ENSP00000357077 ENSP00000357075 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (SM22 alpha)
    Browse Abnova for Human Recombinant Proteins
                  OriGene Purified Recombinant Human Protein: TAGLN2 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005856 cytoskeleton IDA18029348
    GO:0005886 plasma membrane IDA10942595
    GO:0031965 nuclear membrane IDA10942595
    About this table

    Antibodies for TAGLN2: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for TAGLN2
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (SM22 alpha), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for TAGLN2

    Assays for TAGLN2: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    4 InterPro domains/families:
     IPR001061 Transgelin
     IPR001715 Calponin_act_bd
     IPR003096 SM22_calponin
     IPR000557 Calponin_repeat


       GeneDecks  TAGLN2 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P37802

    ProtoNet protein and cluster: P37802

    3 Blocks protein families:
    IPB001061 Smooth muscle protein 22-alpha (transgelin) signature
    IPB001715 Calponin-like actin-binding
    IPB003247 Calponin-like actin-binding subtype


    UniProtKB/Swiss-Prot: TAGL2_HUMAN, P37802
    Similarity: Belongs to the calponin family
    Similarity: Contains 1 calponin-like repeat
    Similarity: Contains 1 CH (calponin-homology) domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (TAGLN2)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003564

                  Applied Biosystems Silencer® siRNAs for TAGLN2

                  Sigma-Aldrich siRNA for TAGLN2  
                         Sigma-Aldrich shRNA for TAGLN2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for TAGLN2
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_003564
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_003564
                                     untagged cDNA clone in CMV expression vector: NM_003564 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_003564

    Genatlas biochemistry entry for TAGLN2:
    transgelin 2,one of the earliest markers of differentiated smooth muscle cells and adult
    tissues,murine 2,Sm22 alpha homolog

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI17353931
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    3 Interacting proteins for TAGLN2 (P378021) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF1BO607391EBI-1056740, EBI-1043343
    EPB41P111711EBI-1056740, EBI-1050906
    VHLP403371EBI-1056740, EBI-301246
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007517 muscle development IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for TAGLN2

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (TAGLN2)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003564

                  Sigma-Aldrich siRNA for TAGLN2  
                         Sigma-Aldrich shRNA for TAGLN2  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_003564  

    REFSEQ mRNAs for TAGLN2 gene: 

    NM_003564.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_003564  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_003564
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_003564
                                     untagged cDNA clone in CMV expression vector: NM_003564 

    Additional cDNA sequence: 

    AJ844623.2 AJ844624.2 AK291562.1 AK298654.1 AY007127.1 BC002616.1 BC009357.2 CR542126.1 
    CR542136.1 CR590131.1 CR590142.1 CR591926.1 CR592747.1 CR592851.1 CR594260.1 CR599010.1 
    CR601283.1 CR602105.1 CR603278.1 CR604118.1 CR604476.1 CR606060.1 CR607405.1 CR607855.1 
    CR608199.1 CR608276.1 CR608575.1 CR609407.1 CR609748.1 CR609777.1 CR610006.1 CR611080.1 
    CR611788.1 CR612553.1 CR613098.1 CR613520.1 CR614100.1 CR616442.1 CR617101.1 CR618095.1 
    CR618563.1 CR618634.1 CR620277.1 CR620855.1 CR621323.1 CR621369.1 CR621718.1 CR621820.1 
    CR622397.1 CR623124.1 CR623657.1 CR624026.1 CR624984.1 CR625445.1 CR626596.1 D21261.1 

    24/62 DOTS entries (see all 62 ):

    DT.75136829  DT.91777498  DT.95278374  DT.91777509  DT.100689339  DT.100689341  DT.100689358  DT.121405748 
    DT.121405845  DT.97846764  DT.95278792  DT.121405853  DT.92019602  DT.95278523  DT.100849499  DT.95278718 
    DT.92002510  DT.100689338  DT.100689340  DT.100689327  DT.100689360  DT.121405920  DT.91777494  DT.95278685 

    24/1765 AceView cDNA sequences (see all 1765 ):

    BM915429 BU751876 BM049354 AI696411 BG424460 BM829749 BU164676 CB306374 
    CF128526 BE273877 BM849199 BQ935711 CR609748 CR622397 CR623657 BP340014 
    BX332839 BP340453 BM917558 CR607405 CR617101 BG285162 BM043982 BQ707593 

    highest scoring ESTs for TAGLN2:

    D21261 BC002616 BC009357 BI226169 BI861515 AA248323 AA459529 AA513797 AA584234 AA604533 

    Unigene Cluster for TAGLN2:

    Transgelin 2
    Hs.517168  [show with all ESTs]
    Unigene Representative Sequence: CR620277


    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for TAGLN2

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:              -                                                                                 
    SP2:                                                                                                
    SP3:                                                                                                

    About this scheme

    ECgene alternative splicing isoforms for TAGLN2

    3 Ensembl transcripts including schematic representations:
    ENST00000368096  ENST00000368097  ENST00000320307  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    TAGLN2 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for TAGLN2

    1 / 2 / 3

    5 probe-sets matching TAGLN2 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    36678_at2, 3 U95-A 2 1.00 0.97 1.00 1.00 D21261 1.00 0.80 0.91 1

    200916_at2, 3 U133-A 1 1.00 1.00 -- -- NM_003564 0.60 0.83 0.73 1

    210978_s_at2, 3 U133-A 1 1.00 1.00 -- -- BC002616 0.80 0.88 0.84 1

    200916_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    210978_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GTCTGGGGCT

    SOURCE GeneReport for Unigene cluster: Hs.517168

    Expression variation in blood from EXPOLDB for TAGLN2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for TAGLN2 gene from 5/11 species (see all 11 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    TAGLN21   -- transgelin 2 92.63(n)
    99.5(a)
    610210  XM_847648.1  XP_852741.1 
    chimpanzee
    (Pan troglodytes)
    TAGLN21   -- transgelin 2 99.33(n)
    100(a)
    469546  XM_524929.2  XP_524929.2 
    cow
    (Bos taurus)
    TAGLN21   -- transgelin 2 93.47(n)
    98.99(a)
    282379  NM_001013599.1  NP_001013617.1 
    rat
    (Rattus norvegicus)
    Tagln21   -- transgelin 2 91.12(n)
    96.98(a)
    304983  NM_001013127.1  NP_001013145.1 
    mouse
    (Mus musculus)
    Tagln21, 5 1 (94.20 cM)5
    transgelin 21, 5 90.45(n)1
    96.48(a)1
    213461  NM_178598.21  NP_848713.11 
     AA4097435  AF1492915  (see all 19)
    About this table        Species with no ortholog for TAGLN2

    ENSEMBL Gene Tree for TAGLN2
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for TAGLN2 gene
    TAGLN2  TAGLN32  

    Pseudogenes
    2 related pseudogenes


    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/43 NCBI SNPs in TAGLN2 are shown (see all 43 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 56)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    --
    rs75133261,2
    A,C,F,H158162160(+) CCGTAG/AACTTG 1 -- ng313Minor allele frequency- A:0.45MN EA WA 454
    rs19340751,2
    A,C,F,H158162603(-) TTTCTC/TCACCC 1 -- ng31 trp38Minor allele frequency- T:0.47NA EA EU WA 2144
    --
    rs107526331,2
    A,C,F,H158162918(+) ATTCTA/GTGCTT 1 -- ng314Minor allele frequency- G:0.45EU EA WA 420
    rs168428261,2
    F,H158161885(+) AGAGCG/AGCGCA 1 -- ut51 ese37Minor allele frequency- A:0.07NA EU EA WA 556
    --
    rs115569571,2
    H158155219(-) AGATCC/TTTCTG 1 / mis1 ese32Minor allele frequency- T:0.00EU WA 208
    rs112652971,2
    A,C,F,H158157083(+) AACTGC/TTACCA 1 -- int112Minor allele frequency- N:0.01EA NA EU WA 1052
    rs22528151,2
    A,C,F,H158156310(-) TGGTGT/CACGCT 1 -- int113Minor allele frequency- C:0.45EA EU WA NA 1942
    rs124051831,2
    H158155528(+) catttG/Cccatc 1 -- int14Minor allele frequency- C:0.00EU EA WA 420
    --
    rs178496361,2
    --158156224(+) GGTACA/TGTGCA 1 L/Q mis10--------
    --
    rs38334361,2
    --158154909(+) GGGAA-/GAAGGAGA 1 -- ut310--------
    About this table

    HapMap Linkage Disequilibrium images for TAGLN2 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 604634

    1 Novoseek disease relationship for TAGLN2 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    neural tube defects 51.45 1 11990753 (1)
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/31 PubMed articles for TAGLN2 gene (see all 31 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 8407 HGNC: 11554 AceView: TAGLN2andNESG1andIGSF9 Ensembl:ENSG00000158710 euGenes: HUgn8407
    ECgene: TAGLN2 H-InvDB: TAGLN2
    (According to HUGE)
    About This Section

    HUGE: KIAA0120
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for TAGLN2:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for TAGLN2-related products

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     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for TAGLN2 Antibodies for TAGLN2
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for TAGLN2 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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    (SM22 alpha)
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     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for TAGLN2




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for TAGLN2

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