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Aliases for TAGLN Gene

Aliases for TAGLN Gene

  • Transgelin 2 3
  • SM22-Alpha 2 3 4
  • SM22 3 4 6
  • Smooth Muscle Protein 22-Alpha 3 4
  • 22 KDa Actin-Binding Protein 3 4
  • Transgelin Variant 2 2 3
  • WS3-10 3 4
  • SMCC 3 6
  • Protein WS3-10 4
  • TAGLN1 3

External Ids for TAGLN Gene

Previous GeneCards Identifiers for TAGLN Gene

  • GC11P119422
  • GC11P118581
  • GC11P117103
  • GC11P116607
  • GC11P116575
  • GC11P117070
  • GC11P113002

Summaries for TAGLN Gene

Entrez Gene Summary for TAGLN Gene

  • The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAGLN Gene

TAGLN (Transgelin) is a Protein Coding gene. GO annotations related to this gene include actin binding. An important paralog of this gene is CNN3.

UniProtKB/Swiss-Prot for TAGLN Gene

  • Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.

Gene Wiki entry for TAGLN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAGLN Gene

Genomics for TAGLN Gene

Regulatory Elements for TAGLN Gene

Transcription factor binding sites by QIAGEN in the TAGLN gene promoter:

Genomic Location for TAGLN Gene

Start:
117,199,321 bp from pter
End:
117,204,792 bp from pter
Size:
5,472 bases
Orientation:
Plus strand

Genomic View for TAGLN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAGLN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAGLN Gene

Proteins for TAGLN Gene

  • Protein details for TAGLN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01995-TAGL_HUMAN
    Recommended name:
    Transgelin
    Protein Accession:
    Q01995
    Secondary Accessions:
    • O15542

    Protein attributes for TAGLN Gene

    Size:
    201 amino acids
    Molecular mass:
    22611 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TAGLN Gene

Proteomics data for TAGLN Gene at MOPED

Post-translational modifications for TAGLN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for TAGLN (Transgelin/TAGLN)

No data available for DME Specific Peptides for TAGLN Gene

Domains for TAGLN Gene

Graphical View of Domain Structure for InterPro Entry

Q01995

UniProtKB/Swiss-Prot:

TAGL_HUMAN :
  • Q01995
Domain:
  • Contains 1 CH (calponin-homology) domain.
Family:
  • Belongs to the calponin family.
Similarity:
  • Contains 1 calponin-like repeat.
genes like me logo Genes that share domains with TAGLN: view

No data available for Gene Families for TAGLN Gene

Function for TAGLN Gene

Molecular function for TAGLN Gene

GENATLAS Biochemistry:
transgelin,22kDa,cytoplasmic,one of the earliest markers of differentiated smooth muscle cells and adult tissues,murine Sm22 alpha homolog,highly expressed in senescent fibroblasts and in fibroblasts from patients with Werner syndrome
UniProtKB/Swiss-Prot Function:
Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.
UniProtKB/Swiss-Prot Induction:
Overexpressed in senescent human fibroblasts

Gene Ontology (GO) - Molecular Function for TAGLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding --
GO:0005515 protein binding IPI 22245152
GO:0051015 actin filament binding IEA --
genes like me logo Genes that share ontologies with TAGLN: view
genes like me logo Genes that share phenotypes with TAGLN: view

miRNA for TAGLN Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAGLN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TAGLN Gene

Localization for TAGLN Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAGLN Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAGLN Gene COMPARTMENTS Subcellular localization image for TAGLN gene
Compartment Confidence
cytoskeleton 3
cytosol 3
extracellular 2
nucleus 2
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TAGLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TAGLN: view

Pathways for TAGLN Gene

SuperPathways for TAGLN Gene

No Data Available

PCR Array Products

Gene Ontology (GO) - Biological Process for TAGLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007517 muscle organ development TAS 9615232
GO:0030855 epithelial cell differentiation IDA 21492153
genes like me logo Genes that share ontologies with TAGLN: view

No data available for Pathways by source for TAGLN Gene

Compounds for TAGLN Gene

(1) HMDB Compounds for TAGLN Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(12) Novoseek inferred chemical compound relationships for TAGLN Gene

Compound -log(P) Hits PubMed IDs
tgf beta1 39.8 6
glyceraldehyde 3-phosphate 31.7 4
retinoic acid 10.7 2
pyruvate 6.86 1
phosphatidylinositol 3.65 1
genes like me logo Genes that share compounds with TAGLN: view

Transcripts for TAGLN Gene

Unigene Clusters for TAGLN Gene

Transgelin:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAGLN

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAGLN Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e · 11f
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - -
SP6: -
SP7: - - - - - - - -
SP8:
SP9: - - - -
SP10:

Relevant External Links for TAGLN Gene

GeneLoc Exon Structure for
TAGLN
ECgene alternative splicing isoforms for
TAGLN

Expression for TAGLN Gene

mRNA expression in normal human tissues for TAGLN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TAGLN Gene

This gene is overexpressed in Artery - Tibial (6.0), Artery - Coronary (5.5), Artery - Aorta (5.1), Esophagus - Muscularis (4.4), and Colon - Sigmoid (4.4).

Protein differential expression in normal tissues for TAGLN Gene

This gene is overexpressed in Seminal vesicle (10.8), Cardia (10.3), Colon muscle (7.6), and Prostate (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAGLN Gene

SOURCE GeneReport for Unigene cluster for TAGLN Gene Hs.410977

genes like me logo Genes that share expressions with TAGLN: view

Expression partners for TAGLN Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TAGLN Gene

Orthologs for TAGLN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAGLN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TAGLN 35
  • 93.7 (n)
  • 98.01 (a)
TAGLN 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAGLN 35
  • 92.7 (n)
  • 97.01 (a)
TAGLN 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tagln 35
  • 91.04 (n)
  • 97.01 (a)
Tagln 16
Tagln 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TAGLN 35
  • 99.67 (n)
  • 100 (a)
TAGLN 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tagln 35
  • 91.71 (n)
  • 97.01 (a)
oppossum
(Monodelphis domestica)
Mammalia TAGLN 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAGLN 35
  • 82.83 (n)
  • 86.5 (a)
TAGLN 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAGLN 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5784 35
tagln 35
  • 73.96 (n)
  • 80.6 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68550 35
zebrafish
(Danio rerio)
Actinopterygii Dr.20602 35
tagln 35
  • 73.23 (n)
  • 73.74 (a)
tagln 36
  • 73 (a)
OneToMany
tagln2 36
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG5023 36
  • 34 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea cpn-2 36
  • 37 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCP1 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
CSA.10356 36
  • 36 (a)
ManyToMany
Species with no ortholog for TAGLN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAGLN Gene

ENSEMBL:
Gene Tree for TAGLN (if available)
TreeFam:
Gene Tree for TAGLN (if available)

Paralogs for TAGLN Gene

Paralogs for TAGLN Gene

Selected SIMAP similar genes for TAGLN Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TAGLN: view

Variants for TAGLN Gene

Sequence variations from dbSNP and Humsavar for TAGLN Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
VAR_048670 -

Structural Variations from Database of Genomic Variants (DGV) for TAGLN Gene

Variant ID Type Subtype PubMed ID
nsv7223 OTHER Inversion 18451855
nsv524270 CNV Loss 19592680

Relevant External Links for TAGLN Gene

HapMap Linkage Disequilibrium report
TAGLN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAGLN Gene

Disorders for TAGLN Gene

(1) University of Copenhagen DISEASES for TAGLN Gene

(11) Novoseek inferred disease relationships for TAGLN Gene

Disease -log(P) Hits PubMed IDs
colon tumor 18.7 3
colorectal cancer 17.1 5
cancer 9.63 6
colon cancer 8.84 1
asthma 6.81 2

Relevant External Links for TAGLN

Genetic Association Database (GAD)
TAGLN
Human Genome Epidemiology (HuGE) Navigator
TAGLN
genes like me logo Genes that share disorders with TAGLN: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot and Genatlas for TAGLN Gene

Publications for TAGLN Gene

  1. A novel gene encoding a smooth muscle protein is overexpressed in senescent human fibroblasts. (PMID: 1520290) Thweatt R. … Goldstein S. (Biochem. Biophys. Res. Commun. 1992) 2 3 4 23
  2. Expression and cytogenetic localization of the human SM22 gene (TAGLN). (PMID: 9615232) Camoretti-Mercado B. … Solway J. (Genomics 1998) 3 4 23
  3. Screening the single nucleotide polymorphisms in patients with internal carotid artery stenosis by oligonucleotide-based custom DNA array. (PMID: 20066125) Nakai K. … Ogawa A. (Bioinform Biol Insights 2009) 3 23 48
  4. Transgelin induces apoptosis of human prostate LNCaP cells through its interaction with p53. (PMID: 20098441) Zhang Z.W. … Chen Z.D. (Asian J. Androl. 2010) 3 23
  5. Gene cloning and nucleotide sequence of SM22 alpha from the chicken gizzard smooth muscle. (PMID: 1872880) Nishida W. … Kiwada K. (Biochem. Int. 1991) 3 4

Products for TAGLN Gene

Sources for TAGLN Gene

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