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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAGLN Gene

protein-coding   GIFtS: 61
GCID: GC11P117070

transgelin
 Explore 40 diseases affiliated with
TAGLN via
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 Human Malady Compendium 
Biological research products
for TAGLN    

Aliases
for TAGLN gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Transgelin1     22 KDa Actin-Binding Protein2 3
SM221 2 3 5     SM22-Alpha1
WS3-101 2 3     DKFZp686P111281
SMCC1 2 5     Transgelin Variant 22
TAGLN11 2     Protein WS3-103
Smooth Muscle Protein 22-Alpha2 3     

External Ids:    HGNC: 115531   Entrez Gene: 68762   Ensembl: ENSG000001495917   OMIM: 6008185   UniProtKB: Q019953   

Export aliases for TAGLN gene to outside databases

Previous GC identifers: GC11P119422 GC11P118581 GC11P117103 GC11P116607 GC11P116575 GC11P113002


Summaries
for TAGLN gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TAGLN:
The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein
found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation
may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear.
Two transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TAGL_HUMAN, Q01995
Function: Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile
properties of the cell that may contribute to replicative senescence

Gene Wiki entry for TAGLN


Genomic Views
for TAGLN gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAGLN gene promoter:
         Sp1   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TAGLN promoter sequence
   Search SABiosciences Chromatin IP Primers for TAGLN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAGLN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.2   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.2

TAGLN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAGLN gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P117070:  view genomic region     (about GC identifiers)

Start:
 117,070,037 bp from pter      End:
 117,075,508 bp from pter
Size:
 5,472 bases      Orientation:
 plus strand

Proteins
for TAGLN gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TAGL_HUMAN, Q01995 (See protein sequence)
Recommended Name: Transgelin  
Size: 201 amino acids; 22611 Da
Subcellular location: Cytoplasm (Probable)
Secondary accessions: O15542

Explore the universe of human proteins at neXtProt for TAGLN: NX_Q01995

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q01995

    • TAGLN Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001001522.1  NP_003177.2  

    ENSEMBL proteins: 
     ENSP00000376678   ENSP00000432054   ENSP00000278968   ENSP00000431862   ENSP00000431941  
     ENSP00000432282   ENSP00000432380  

    Human Recombinant Protein Products: 
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    OriGene Purified Proteins (see all 2): TAGLN
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    Novus Biologicals TAGLN Proteins
    Novus Biologicals TAGLN Lysates
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    ProSpec Recombinant Protein for TAGLN
    Uscn Proteins for TAGLN

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--


    TAGLN for ontologies           About GeneDecksing



    TAGLN Antibody Products: 
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    R&D Systems Antibodies for TAGLN (Transgelin/TAGLN)
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    Uscn ELISAs and CLIAs for TAGLN

    Protein Domains /
    Families
    for TAGLN gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TAGLN for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001061 TAGLN
     IPR001715 CH-domain
     IPR003096 SM22_calponin
     IPR000557 Calponin_repeat

    Graphical View of Domain Structure for InterPro Entry Q01995

    ProtoNet protein and cluster: Q01995

    3 Blocks protein families:
    IPB001061 Smooth muscle protein 22-alpha (transgelin) signature
    IPB001715 Calponin-like actin-binding
    IPB003247 Calponin-like actin-binding subtype


    UniProtKB/Swiss-Prot: TAGL_HUMAN, Q01995
    Similarity: Belongs to the calponin family
    Similarity: Contains 1 calponin-like repeat
    Similarity: Contains 1 CH (calponin-homology) domain


    Function
    for TAGLN gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TAGL_HUMAN, Q01995
    Function: Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile
    properties of the cell that may contribute to replicative senescence
    Induction: Overexpressed in senescent human fibroblasts

         Genatlas biochemistry entry for TAGLN:
    transgelin,22kDa,cytoplasmic,one of the earliest markers of differentiated smooth muscle cells and adult tissues,murine
    Sm22 alpha homolog,highly expressed in senescent fibroblasts and in fibroblasts from patients with Werner syndrome

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): TAGLN
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TAGLN
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate TAGLN:
    hsa-miR-485-5p hsa-miR-22 hsa-miR-4316 hsa-miR-100* hsa-miR-539 hsa-miR-558 hsa-miR-143* hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmid: TAGLN 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TAGLN (see all 7)
    OriGene shRNA RFP: TAGLN
    OriGene siRNA: TAGLN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAGLN

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TAGLN

    Clone
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    Cell Line
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    LifeMap BioReagents: cell lines associated with TAGLN: PureStem ES-210, Ecto-ntu Progenitor,
    PureStem Z11, Meso Progenitor

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAGLN

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--


    TAGLN for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for TAGLN:
     Decreased viability with carbo 

    Animal Models:
         13 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Tagln):
     behavior/neurological  cardiovascular system  digestive/alimentary  growth/size  immune system 
     mortality/aging  muscle  nervous system  normal  renal/urinary system 
     reproductive system  skeleton  tumorigenesis 

    TAGLN for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TAGLN gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TAGLN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    5/17 Interacting proteins for TAGLN (Q019952, 3 ENSP000002789684) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IGF1RP080692, ENSP000002680354MINT-8301962 MINT-8301951 STRING: ENSP00000268035
    PRKCDQ056553, ENSP000003316024I2D: score=2 STRING: ENSP00000331602
    ACTA1P681333, ENSP000003556454I2D: score=3 STRING: ENSP00000355645
    AGR2O959943, ENSP000003914904I2D: score=1 STRING: ENSP00000391490
    CFL1P235283, ENSP000003096294I2D: score=2 STRING: ENSP00000309629
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007517muscle organ development IEA--


    TAGLN for ontologies           About GeneDecksing



    Drugs & Compounds
    for TAGLN gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TAGLN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TAGLN

    1 HMDB Compound for TAGLN    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    10/12 Novoseek chemical compound relationships for TAGLN gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tgf beta1 39.8 9 16876108 (3), 15217807 (2), 20368328 (1)
    glyceraldehyde 3-phosphate 31.7 5 15986332 (1), 19767541 (1), 17332923 (1), 11904414 (1)
    retinoic acid 10.7 4 18511453 (1), 19486889 (1)
    pyruvate 6.86 1 19767541 (1)
    phosphatidylinositol 3.65 1 16310342 (1)
    superoxide 1.94 4 16035116 (1), 19288589 (1), 15986332 (1), 17332923 (1)
    calcium 0 2 1520290 (1)
    tyrosine 0 1 14630650 (1)
    fatty acid 0 3 11716502 (1), 11904414 (1), 19082487 (1)
    arginine 0 1 12829429 (1)

    Search CenterWatch for drugs/clinical trials and news about TAGLN / TAGL 

    Transcripts
    for TAGLN gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TAGLN gene (2 alternative transcripts): 
    NM_001001522.1  NM_003186.3  

    Unigene Cluster for TAGLN:

    Transgelin
    Hs.410977  [show with all ESTs]
    Unigene Representative Sequence: AB209555
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392951 ENST00000525531 ENST00000278968(uc001pql.1 uc001pqm.3 uc001pqn.3)
    ENST00000529792 ENST00000533863 ENST00000530649(uc001pqo.3) ENST00000532870(uc001pqp.3)
    ENST00000529622

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TAGLN
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate TAGLN:
    hsa-miR-485-5p hsa-miR-22 hsa-miR-4316 hsa-miR-100* hsa-miR-539 hsa-miR-558 hsa-miR-143* hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmid: TAGLN 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TAGLN (see all 7)
    OriGene shRNA RFP: TAGLN
    OriGene siRNA: TAGLN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAGLN
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): TAGLN (NM_003186)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAGLN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAGLN 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAGLN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAGLN

    Additional cDNA sequence: 

    AB209555.1 AK223002.1 AK314043.1 BC004927.1 BC010946.1 BC065829.1 BC092415.1 BC093050.1 
    BT019648.1 BT019649.1 BX640723.1 CR536484.1 CR541681.1 D17409.1 M83106.1 M95787.1 

    24/49 DOTS entries (see all 49):

    DT.450977  DT.92461872  DT.100688943  DT.102840249  DT.100688949  DT.100664339  DT.95332543  DT.95333302 
    DT.92461860  DT.100688951  DT.100805934  DT.95162555  DT.100688936  DT.100041913  DT.100805938  DT.95073168 
    DT.421136  DT.120753112  DT.100871648  DT.120753132  DT.95207334  DT.100805943  DT.40278703  DT.95162477 

    24/889 AceView cDNA sequences (see all 889):

    CA420508 BM835984 CA414788 BG680357 CF131075 BI768805 BG742579 BI760162 
    CA390245 AK075137 BU150482 AI598015 BM718768 CA412584 BF434280 BM672802 
    CR594882 BQ010011 AI686113 BQ004206 AI459431 BM694221 CA412363 BQ010086 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for TAGLN (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e · 11f
    SP1:                    -     -     -     -     -     -           -                                                               
    SP2:                    -     -     -     -     -     -                                                                           
    SP3:                          -     -     -     -     -                                                                           
    SP4:                          -     -     -     -     -                                                                           
    SP5:                                            -     -                                                                           


    ECgene alternative splicing isoforms for TAGLN

    Expression
    for TAGLN gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TAGLN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACAGGCTACG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TAGLN expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/23 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 23) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EndotheliumVeinsVascular Smooth Muscle CellsSmooth Muscle
    HeartAortic Arch ArteriesVascular Smooth Muscle CellsMyocardium, Neural Crest, Smooth Muscle
    HeartEndocardiumVascular Smooth Muscle CellsSmooth Muscle
    Extraembryonic MesodermExtraembryonic MesodermExtraembryonic Mural CellsExtraembryonic Tissues
    HeartCoronary Capillary PlexusVascular Smooth Muscle CellsEpicardium, Smooth Muscle
    Lateral Plate MesodermSplanchnic MesodermMural CellsPericytes, Smooth Muscle
    Gut TubeHindgutHindgut Endoderm CellsEndoderm
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    BoneRostral Endochondral Facial BonesBone
    BoneRostral Skull Membranous BonesBone
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/19 LifeMap Cells (see all 19) 
    NameCategory
    PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)Heart, Myocardium, Smooth Muscle
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    Neuroectoderm-derived smooth muscle cells (Generation of human ...)
    Lateral plate mesoderm-derived smooth muscle cells (Generation of human ...)

    See TAGLN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TAGLN

    SOURCE GeneReport for Unigene cluster: Hs.410977
        SABiosciences Expression via Pathway-Focused PCR Arrays including TAGLN: 
              Terminal Differentiation Markers in human mouse rat
              Wound Healing in human mouse rat
              Hepatotoxicity in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAGLN

    Orthologs
    for TAGLN gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TAGLN gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TAGLN1 transgelin 82.83(n)
    86.5(a)    		   396490  NM_205494.1  NP_990825.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TAGLN6
    		 --
    		 72(a)
    		 1 ↔ 1
    		 GL343949.1(98102-104039)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC685502 hypothetical protein MGC68550 78.23(n)    BC061650.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.206022 Transcribed sequence with moderate similarity to protein more 74.57(n)    BI846015.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Mp206
    Chd646
    (see all 3)    		 Chd64
    (see all 3)    		 40(a)
    38(a)
    (see all 3)    		 possible ortholog
    possible ortholog
    (see all 3)    		 2R(9134175-9135264)
    3L(4114289-4122388)
    worm
    (Caenorhabditis elegans)    		 Secernentea cpn-26
    cpn-16
    (see all 4)    		 CalPoNin family member (cpn-1)
    (see all 4)    		 38(a)
    36(a)
    (see all 4)    		 1 ↔ many
    possible ortholog
    (see all 4)    		 II(337339-339248)
    I(8636114-8637955)


    ENSEMBL Gene Tree for TAGLN (if available)
    TreeFam Gene Tree for TAGLN (if available) 

    Paralogs
    for TAGLN gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TAGLN gene
    TAGLN22  CNN12  CNN32  TAGLN32  CNN22  
    5 SIMAP similar genes for TAGLN using alignment to 6 protein entries:     TAGL_HUMAN (see all proteins):
    TAGLN2    TAGLN3    CNN3    CNN1    CNN2

    TAGLN for paralogs           About GeneDecksing



    Genomic Variants
    for TAGLN gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/183 NCBI SNPs in TAGLN are shown (see all 183)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1807112151,2
    		--117068336(+) TTACCA/GGGGCA 4 -- int1 us2k1 ds50010--------
    rs1458858031,2
    		--117068429(+) CAGCAA/GTCTCT 4 -- ds5001 int1 us2k10--------
    rs1394358541,2
    		--117068432(+) CAGTCG/TCTGCC 4 -- ds5001 int1 us2k10--------
    rs735786961,2
    		C,--117068441(+) CCCACC/GTGGCC 4 -- us2k1 int1 ds50012Minor allele frequency- G:0.06WA 120
    rs743859341,2
    		C,--117068444(+) ACCTGG/ACCCCG 4 -- int1 us2k1 ds50013Minor allele frequency- A:0.12CSA WA EA 240
    rs1450550771,2
    		--117068447(+) TGGCCC/TCGCCC 4 -- us2k1 int1 ds50010--------
    rs1861060351,2
    		--117068449(+) GCCCCA/GCCCAC 4 -- ds5001 int1 us2k10--------
    rs5885341,2
    		C,F,H,--117068504(-) GTGGCC/TTGGTG 4 -- ds5001 us2k1 nc-transcript-variant19Minor allele frequency- T:0.44MN EA NA NS WA CSA 2449
    rs20755471,2
    		C,F,H,--117068534(+) TGATGC/AGGCGT 4 -- nc-transcript-variantus2k1 ds500119Minor allele frequency- A:0.10EA NS NA WA 3642
    rs1475818411,2
    		--117068645(+) GACTTC/TAGTCG 4 -- ds5001 us2k1 int10--------

    HapMap Linkage Disequilibrium report for TAGLN (117070037 - 117075508 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TAGLN: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAGLN
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    Disorders / Diseases
    for TAGLN gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TAGLN for disorders           About GeneDecksing

    OMIM gene information: 600818    OMIM disorders: --

    20/40 diseases for TAGLN (see all 40):    About MalaCards
    muscle hypertrophy    esophageal squamous cell carcinoma    squamous cell carcinoma    aortic aneurysm
    peyronie's disease    peyronies disease    megakaryoblastic leukemia    werner syndrome
    ulcerative colitis    liver cirrhosis    renal cell carcinoma    schistosomiasis
    keloids    colorectal cancer    carcinoma    gastric adenocarcinoma
    prostate cancer    liver cancer    hepatocellular carcinoma    cervical cancer

    1 disease from the University of Copenhagen DISEASES database for TAGLN:
    Small cell carcinoma

    10/11 Novoseek disease relationships for TAGLN gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon tumor 18.7 3 16402363 (2), 11773051 (1)
    colorectal cancer 17.1 9 19329940 (5)
    cancer 9.63 10 18446369 (3), 19711377 (1), 19848416 (1), 15547752 (1)
    colon cancer 8.84 1 16402363 (1)
    asthma 6.81 2 19011151 (2)
    prostate cancer 6.56 10 20012321 (5), 17082327 (3), 17267660 (1)
    tumors 5.14 9 19329940 (1), 11503213 (1), 16645950 (1), 19771267 (1) (see all 7)
    shock 4.01 5 12923326 (1), 15378762 (1), 16035116 (1), 19771267 (1) (see all 5)
    carcinoma squamous cell 0 2 19771267 (1), 16051329 (1)
    cancer lung 0 1 15378762 (1)

    Human Genome Epidemiology (HuGE) Navigator: TAGLN (6 documents)

    Export disorders for TAGLN gene to outside databases

    Publications
    for TAGLN gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TAGLN gene, integrated from 9 sources (see all 163):
    (articles sorted by number of sources associating them with TAGLN)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel gene encoding a smooth muscle protein is overexpressed in senescent human fibroblasts. (PubMed id 1520290)1, 2, 3, 9 Thweatt R....Goldstein S. (1992)
    2. Expression and cytogenetic localization of the human SM22 gene (TAGLN). (PubMed id 9615232)1, 2, 9 Camoretti-Mercado B....Solway J. (1998)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Structure and expression of the human SM22alpha gene, assignment of the gene to chromosome 11, and repression of the promoter activity by cytosine DNA methylation. (PubMed id 9276683)1, 2 Yamamura H.... Takahashi K. (1997)
    5. Purification, characterization, and partial sequence analysis of a new 25-kDa actin-binding protein from bovine aorta: a SM22 homolog. (PubMed id 8117285)1, 3 Kobayashi R....Hidaka H. (1994)
    6. Gene cloning and nucleotide sequence of SM22 alpha from the chicken gizzard smooth muscle. (PubMed id 1872880)1, 2 Nishida W.... Kiwada K. (1991)
    7. Transgelin as a suppressor is associated with poor pr ognosis in colorectal carcinoma patients. (PubMed id 19329940)1, 9 Zhao L....Ding Y.Q. (2009)
    8. Expression of the actin-associated protein transgelin (SM22) is decreased in prostate cancer. (PubMed id 20012321)1, 9 Prasad P.D....Assinder S.J. (2010)
    9. Transgelin induces apoptosis of human prostate LNCaP cells through its interaction with p53. (PubMed id 20098441)1, 9 Zhang Z.W....Chen Z.D. (2010)
    10. Mutagenesis analysis of human SM22: characterization of actin binding. (PubMed id 11053353)1, 9 Fu Y....Solway J. (2000)

    External Searches for TAGLN gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TAGLN gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6876 HGNC: 11553 AceView: TAGLNandSIDT2 Ensembl:ENSG00000149591 euGenes: HUgn6876
    ECgene: TAGLN H-InvDB: TAGLN

    Other Databases showing TAGLN gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TAGLN gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TAGLN Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TAGLN gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TAGLN gene:
    Search GeneIP for patents involving TAGLN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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     TAGLN Proteins, Antibodies, CLIAs, and ELISAs
     Cell Lines associated with TAGLN: PureStem ES-210, Ecto-ntu Progenitor,
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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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