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Aliases for TAGLN Gene

Aliases for TAGLN Gene

  • Transgelin 2 3 5
  • SM22-Alpha 2 3 4
  • Smooth Muscle Protein 22-Alpha 3 4
  • 22 KDa Actin-Binding Protein 3 4
  • Transgelin Variant 2 2 3
  • WS3-10 3 4
  • SM22 3 4
  • Protein WS3-10 4
  • TAGLN1 3
  • SMCC 3

External Ids for TAGLN Gene

Previous GeneCards Identifiers for TAGLN Gene

  • GC11P119422
  • GC11P118581
  • GC11P117103
  • GC11P116607
  • GC11P116575
  • GC11P117070
  • GC11P113002

Summaries for TAGLN Gene

Entrez Gene Summary for TAGLN Gene

  • The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAGLN Gene

TAGLN (Transgelin) is a Protein Coding gene. Diseases associated with TAGLN include laryngeal small cell carcinoma and gastric small cell carcinoma. GO annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is CNN3.

UniProtKB/Swiss-Prot for TAGLN Gene

  • Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.

Gene Wiki entry for TAGLN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAGLN Gene

Genomics for TAGLN Gene

Regulatory Elements for TAGLN Gene

Promoters for TAGLN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TAGLN on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TAGLN gene promoter:

Genomic Location for TAGLN Gene

Chromosome:
11
Start:
117,199,321 bp from pter
End:
117,204,792 bp from pter
Size:
5,472 bases
Orientation:
Plus strand

Genomic View for TAGLN Gene

Genes around TAGLN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAGLN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAGLN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAGLN Gene

Proteins for TAGLN Gene

  • Protein details for TAGLN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01995-TAGL_HUMAN
    Recommended name:
    Transgelin
    Protein Accession:
    Q01995
    Secondary Accessions:
    • O15542

    Protein attributes for TAGLN Gene

    Size:
    201 amino acids
    Molecular mass:
    22611 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TAGLN Gene

Proteomics data for TAGLN Gene at MOPED

Post-translational modifications for TAGLN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for TAGLN (Transgelin/TAGLN)

No data available for DME Specific Peptides for TAGLN Gene

Domains & Families for TAGLN Gene

Graphical View of Domain Structure for InterPro Entry

Q01995

UniProtKB/Swiss-Prot:

TAGL_HUMAN :
  • Contains 1 CH (calponin-homology) domain.
  • Belongs to the calponin family.
  • Contains 1 calponin-like repeat.
Domain:
  • Contains 1 CH (calponin-homology) domain.
Family:
  • Belongs to the calponin family.
Similarity:
  • Contains 1 calponin-like repeat.
genes like me logo Genes that share domains with TAGLN: view

No data available for Gene Families for TAGLN Gene

Function for TAGLN Gene

Molecular function for TAGLN Gene

GENATLAS Biochemistry:
transgelin,22kDa,cytoplasmic,one of the earliest markers of differentiated smooth muscle cells and adult tissues,murine Sm22 alpha homolog,highly expressed in senescent fibroblasts and in fibroblasts from patients with Werner syndrome
UniProtKB/Swiss-Prot Function:
Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.
UniProtKB/Swiss-Prot Induction:
Overexpressed in senescent human fibroblasts.

Gene Ontology (GO) - Molecular Function for TAGLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
genes like me logo Genes that share ontologies with TAGLN: view
genes like me logo Genes that share phenotypes with TAGLN: view

Animal Models for TAGLN Gene

MGI Knock Outs for TAGLN:

Animal Model Products

  • Taconic Biosciences Mouse Models for TAGLN

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAGLN Gene

Localization for TAGLN Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAGLN Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAGLN Gene COMPARTMENTS Subcellular localization image for TAGLN gene
Compartment Confidence
cytosol 4
cytoskeleton 2
extracellular 2
nucleus 2
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for TAGLN Gene

Pathways & Interactions for TAGLN Gene

SuperPathways for TAGLN Gene

No Data Available

SIGNOR curated interactions for TAGLN Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TAGLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030855 epithelial cell differentiation IDA 21492153
genes like me logo Genes that share ontologies with TAGLN: view

No data available for Pathways by source for TAGLN Gene

Drugs & Compounds for TAGLN Gene

(6) Drugs for TAGLN Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(6) Additional Compounds for TAGLN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TAGLN: view

Transcripts for TAGLN Gene

Unigene Clusters for TAGLN Gene

Transgelin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAGLN Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e · 11f
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - -
SP6: -
SP7: - - - - - - - -
SP8:
SP9: - - - -
SP10:

Relevant External Links for TAGLN Gene

GeneLoc Exon Structure for
TAGLN
ECgene alternative splicing isoforms for
TAGLN

Expression for TAGLN Gene

mRNA expression in normal human tissues for TAGLN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TAGLN Gene

This gene is overexpressed in Artery - Tibial (x6.0), Artery - Coronary (x5.5), Artery - Aorta (x5.1), Esophagus - Muscularis (x4.4), and Colon - Sigmoid (x4.4).

Protein differential expression in normal tissues from HIPED for TAGLN Gene

This gene is overexpressed in Seminal vesicle (10.8), Cardia (10.3), Colon muscle (7.6), and Prostate (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAGLN Gene



SOURCE GeneReport for Unigene cluster for TAGLN Gene Hs.410977

genes like me logo Genes that share expression patterns with TAGLN: view

Protein tissue co-expression partners for TAGLN Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TAGLN Gene

Orthologs for TAGLN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAGLN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAGLN 35
  • 99.67 (n)
  • 100 (a)
TAGLN 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAGLN 36
  • 98 (a)
OneToOne
TAGLN 35
  • 93.7 (n)
  • 98.01 (a)
dog
(Canis familiaris)
Mammalia TAGLN 35
  • 92.7 (n)
  • 97.01 (a)
TAGLN 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tagln 36
  • 97 (a)
OneToOne
Tagln 16
Tagln 35
  • 91.04 (n)
  • 97.01 (a)
oppossum
(Monodelphis domestica)
Mammalia TAGLN 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tagln 35
  • 91.71 (n)
  • 97.01 (a)
chicken
(Gallus gallus)
Aves TAGLN 36
  • 87 (a)
OneToOne
TAGLN 35
  • 82.83 (n)
  • 86.5 (a)
lizard
(Anolis carolinensis)
Reptilia TAGLN 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68550 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5784 35
tagln 35
  • 73.96 (n)
  • 80.6 (a)
zebrafish
(Danio rerio)
Actinopterygii tagln 36
  • 73 (a)
OneToMany
tagln2 36
  • 69 (a)
OneToMany
Dr.20602 35
tagln 35
  • 73.23 (n)
  • 73.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5023 36
  • 34 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea cpn-2 36
  • 37 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCP1 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
CSA.10356 36
  • 36 (a)
ManyToMany
Species with no ortholog for TAGLN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAGLN Gene

ENSEMBL:
Gene Tree for TAGLN (if available)
TreeFam:
Gene Tree for TAGLN (if available)

Paralogs for TAGLN Gene

Paralogs for TAGLN Gene

(5) SIMAP similar genes for TAGLN Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TAGLN: view

Variants for TAGLN Gene

Sequence variations from dbSNP and Humsavar for TAGLN Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs12284316 - 117,204,298(+) CAGCA(A/G)CAGAG reference, missense
rs1804915 -- 117,204,483(+) TCTGT(C/T)ACTGA utr-variant-3-prime
rs113278237 -- 117,204,109(+) AAGTG(A/C)AACAG intron-variant
rs143022570 -- 117,204,287(+) CTTCA(G/T)ATGGG reference, missense
rs112876883 -- 117,204,214(+) TTCTA(A/G)GAAAG splice-acceptor-variant

Structural Variations from Database of Genomic Variants (DGV) for TAGLN Gene

Variant ID Type Subtype PubMed ID
nsv7223 OTHER Inversion 18451855
nsv524270 CNV Loss 19592680

Variation tolerance for TAGLN Gene

Residual Variation Intolerance Score: 57.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.09; 38.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAGLN Gene

HapMap Linkage Disequilibrium report
TAGLN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAGLN Gene

Disorders for TAGLN Gene

MalaCards: The human disease database

(4) MalaCards diseases for TAGLN Gene - From: DISEASES

Disorder Aliases PubMed IDs
laryngeal small cell carcinoma
  • small cell carcinoma of larynx
gastric small cell carcinoma
  • small cell carcinoma of stomach
malignant fibrous histiocytoma of bone
  • malignant fibrous histiocytoma of the bone
cervix small cell carcinoma
  • small cell carcinoma of the cervix
- elite association - COSMIC cancer census association via MalaCards
Search TAGLN in MalaCards View complete list of genes associated with diseases

Relevant External Links for TAGLN

Genetic Association Database (GAD)
TAGLN
Human Genome Epidemiology (HuGE) Navigator
TAGLN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAGLN
genes like me logo Genes that share disorders with TAGLN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAGLN Gene

Publications for TAGLN Gene

  1. A novel gene encoding a smooth muscle protein is overexpressed in senescent human fibroblasts. (PMID: 1520290) Thweatt R. … Goldstein S. (Biochem. Biophys. Res. Commun. 1992) 2 3 4 23 67
  2. Expression of the actin-associated protein transgelin (SM22) is decreased in prostate cancer. (PMID: 20012321) Prasad P.D. … Assinder S.J. (Cell Tissue Res. 2010) 3 23
  3. Transgelin induces apoptosis of human prostate LNCaP cells through its interaction with p53. (PMID: 20098441) Zhang Z.W. … Chen Z.D. (Asian J. Androl. 2010) 3 23
  4. Myosin, transgelin, and myosin light chain kinase: expression and function in asthma. (PMID: 19011151) Leguillette R. … Lauzon A.-M. (Am. J. Respir. Crit. Care Med. 2009) 3 23
  5. Up-regulation of two actin-associated proteins prompts pulmonary artery smooth muscle cell migration under hypoxia. (PMID: 19188659) Zhang R. … Wan H. (Am. J. Respir. Cell Mol. Biol. 2009) 3 23

Products for TAGLN Gene

Sources for TAGLN Gene

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