Aliases for TAGLN Gene
External Ids for TAGLN Gene
Previous GeneCards Identifiers for TAGLN Gene
The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for TAGLN Gene
TAGLN (Transgelin) is a Protein Coding gene. Diseases associated with TAGLN include laryngeal small cell carcinoma and malignant fibrous histiocytoma of bone. GO annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is CNN3.
UniProtKB/Swiss-Prot for TAGLN Gene
Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.