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TAGLN Gene

protein-coding GIFtS: 57

GC11P116575

transgelin
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZp686B01212 ^²
DKFZp686P11128 ^¹, ²
SM22 ^¹, ², ³, ⁵
SM22-alpha ^², ³
SMCC ^¹, ², ⁵
TAGLN1 ^¹, ²
WS3-10 ^¹, ², ³
transgelin ^²

Descriptions
22 kDa actin-binding protein ^³
Smooth muscle protein 22-alpha ^³
transgelin variant 2 ^²

External Ids
HGNC: 11553¹
Entrez Gene: 6876²
UniProtKB: Q01995³
Ensembl: ENSG00000149591⁷

Search outside databases for aliases for TAGLN gene

Previous GC identifers: GC11P119422 GC11P118581 GC11P117103 GC11P116607

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TAGLN:

The protein encoded by this gene is a transformation and shape-change sensitive actin

cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is

down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker

for the onset of transformation. A functional role of this protein is unclear. Two transcript

variants encoding the same protein have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: TAGL_HUMAN, Q01995

Function: Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and

contractile properties of the cell that may contribute to replicative senescence

Gene Wiki entry for TAGLN

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TAGLN gene

Entrez Gene cytogenetic band: 11q23.2 Ensembl cytogenetic band: 11q23.3 HGNC cytogenetic band: 11q23.2

TAGLN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P116575: (about GC identifiers)

Start:	116,575,250 bp from pter
End:	116,580,718 bp from pter
Size:	5,469 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_033899.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TAGL_HUMAN, Q01995 (See protein sequence)

Recommended Name: Transgelin

Size: 201 amino acids; 22611 Da

Subcellular location: Cytoplasm (Probable)

Secondary accessions: O15542

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001001522.1 NP_003177.2

ENSEMBL proteins:

ENSP00000364427 ENSP00000278968 ENSP00000376678

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (SM22 alpha)
	Human Recombinant Proteins from Abnova (TAGLN)

OriGene Purified Recombinant Human Proteins (see all 2): TAGLN

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--

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Antibodies for TAGLN:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for TAGLN
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (SM22 alpha), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TAGLN)
	Novus Biologicals Antibodies for TAGLN

Assays for TAGLN:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q01995

ProtoNet protein and cluster: Q01995

3 Blocks protein families:

IPB001061 Smooth muscle protein 22-alpha (transgelin) signature

IPB001715 Calponin-like actin-binding

IPB003247 Calponin-like actin-binding subtype

UniProtKB/Swiss-Prot: TAGL_HUMAN, Q01995

Similarity: Belongs to the calponin family

Similarity: Contains 1 calponin-like repeat

Similarity: Contains 1 CH (calponin-homology) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TAGLN)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003186

Applied Biosystems Silencer® siRNAs for TAGLN

Sigma-Aldrich siRNA for TAGLN

Sigma-Aldrich shRNA for TAGLN

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for TAGLN
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001001522
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001001522
untagged cDNA clones in CMV expression vector (see all 2): NM_001001522

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003186

UniProtKB/Swiss-Prot: TAGL_HUMAN, Q01995

Function: Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and

contractile properties of the cell that may contribute to replicative senescence

Induction: Overexpressed in senescent human fibroblasts

Genatlas biochemistry entry for TAGLN:

transgelin,22kDa,cytoplasmic,one of the earliest markers of differentiated smooth muscle cells and

adult tissues,murine Sm22 alpha homolog,highly expressed in senescent fibroblasts and in

fibroblasts from patients with Werner syndrome

11 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Tagln):

	behavior/neurological	digestive/alimentary	growth/size	immune system
life span-post-weaning/aging	normal	renal/urinary system	reproductive system	skeleton
tumorigenesis

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--
GO:0005515	protein binding	IPI	17353931

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for TAGLN

5/19 Interacting proteins for TAGLN (ENSP00000278968³ Q01995¹) via UniProtKB, MINT, and/or STRING (see all 19 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CFL1	P23528¹	EBI-1054248, EBI-352733
GIPC1	O14908¹	EBI-1054248, EBI-373132
S100A9	P06702¹	EBI-1054248, EBI-1055001
MYOCD	ENSP00000348415³	STRING (score=.992)
SRF	ENSP00000265354³	STRING (score=.936)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007517	muscle development	TAS	9615232

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TAGLN
7 Novoseek chemical compound relationships for TAGLN gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tgf beta1	32.17	7	16876108 (3), 15217807 (2)
glyceraldehyde 3-phosphate	26.98	4	15986332 (1), 17332923 (1), 11904414 (1)
phosphatidylinositol	7.94	1	16310342 (1)
superoxide	0.00	4	16035116 (1), 19288589 (1), 15986332 (1), 17332923 (1)
calcium	0.00	2	1520290 (1)
tyrosine	0.00	1	14630650 (1)
fatty acid	0.00	3	11716502 (1), 11904414 (1), 19082487 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TAGLN)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_003186

Sigma-Aldrich siRNA for TAGLN

Sigma-Aldrich shRNA for TAGLN

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001001522 NM_003186

REFSEQ mRNAs for TAGLN gene (2 alternative transcripts):

NM_001001522.1 NM_003186.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001001522 NM_003186

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001001522
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001001522
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001001522

Additional cDNA sequence:

AB209555.1 AK223002.1 AK314043.1 BC004927.1 BC010946.1 BC065829.1 BC092415.1 BC093050.1

BT019648.1 BT019649.1 BX640723.1 CR536484.1 CR541681.1 CR592460.1 CR594443.1 CR594882.1

CR597887.1 CR600882.1 CR605812.1 CR606909.1 CR611459.1 CR612359.1 CR615909.1 CR626280.1

D17409.1 M83106.1 M95787.1

24/51 DOTS entries (see all 51 ):

DT.450977 DT.92461872 DT.100688943 DT.102840249 DT.95332543 DT.100688949 DT.100664339 DT.95333302

DT.92461860 DT.100688951 DT.100805934 DT.100805938 DT.95162555 DT.100041913 DT.100688936 DT.421136

DT.100871648 DT.95073168 DT.120753112 DT.120753132 DT.95207334 DT.100805943 DT.40278703 DT.91757737

24/889 AceView cDNA sequences (see all 889 ):

AI754513 CD616561 BM694262 BC041624 AK075137 AI753279 Z39199 BU627814

CA414910 CA488955 CA412584 AI754472 BE907538 BQ004206 AI446240 BQ777879

BQ027112 BU682453 BM988481 F05615 BF002907 BF222699 BM788990 CR605812

highest scoring ESTs for TAGLN:

D17409 AA160872 AA291505 AA320531 AA363326 AA365766 AA367378 AA371322 AA374465 AA385898

Unigene Cluster for TAGLN:

Transgelin

Hs.410977 [show with all ESTs]

Unigene Representative Sequence: AB209555

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for TAGLN (see all 10 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	^	7	^	8	^	9	^	10	^	11a	·	11b	·	11c	·	11d	·	11e	·	11f
SP1:							-		-		-		-		-		-				-
SP2:							-		-		-		-		-		-
SP3:									-		-		-		-		-
SP4:									-		-		-		-		-
SP5:															-		-

About this scheme

ECgene alternative splicing isoforms for TAGLN

3 Ensembl transcripts including schematic representations:

ENST00000375278 ENST00000278968 ENST00000392951

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TAGLN expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TAGLN

¹ / ² / ³

8 probe-sets matching TAGLN gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36931_at²^{, 3}	U95-A	1	1.00	1.00	0.96	1.19	D17409	1.00	0.90	0.95	1
78547_at²^{, 3}	U95-E	1	0.94	1.00	0.92	1.01	AI082237	0.40	0.38	0.39	2
82657_f_at²^{, 3}	U95-D	2	0.46	0.50	0.83	0.81	W48800	0.20	0.12	0.17	2
226523_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI082237	0.40	0.38	0.39	2
205547_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003186	0.60	0.83	0.73	1
226523_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205547_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555724_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks TAGLN for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ACAGGCTACG

SOURCE GeneReport for Unigene cluster: Hs.410977
Expression variation in blood from EXPOLDB for TAGLN

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TAGLN gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TAGLN¹	--	transgelin	92.7(n) 97.01(a)	479424 XM_536561.2 XP_536561.2
cow (Bos taurus)	TAGLN¹	--	transgelin	93.7(n) 98.01(a)	513463 NM_001046149.1 NP_001039614.1
rat (Rattus norvegicus)	Tagln¹	--	transgelin	91.71(n) 97.01(a)	25123 NM_031549.1 NP_113737.1
mouse (Mus musculus)	Tagln^{1, 5}	9 (27.00 cM)⁵	transgelin^{1, 5}	91.04(n)¹ 97.01(a)¹	21345¹ NM_011526.3¹ NP_035656.1¹ AK002880⁵ AK028131⁵ (see all 15)
chicken (Gallus gallus)	TAGLN¹	--	transgelin	82.83(n) 86.5(a)	396490 NM_205494.1 NP_990825.1

About this table Species with no ortholog for TAGLN

ENSEMBL Gene Tree for TAGLN

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TAGLN gene

TAGLN2² TAGLN3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/53 NCBI SNPs in TAGLN are shown (see all 53 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 56)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs585849^1,2	A,C,F	116574271(-)	`GGATCC/TTGGGG`	2	--	ng5¹		2		MN NS	224
	rs474488^1,2	A,C,F	116574187(-)	`GGGCAC/TCTGGT`	2	--	ng5¹		6		EA NA MN NS	374
	rs12284316^1,2	C,F	116580224(+)	`CAGCAA/GCAGAG`	2	N/S	mis¹ ese³		5		NA EU EA WA	476
	rs2269398^1,2	C	116574998(-)	`TGCCCA/GGACTT`	2	--	ng5¹		0	--	--	--	--
--	rs7104286^1,2	A	116575541(+)	`CTAGCA/GTCCTG`	2	--	ut5¹ int¹ ese³		0	--	--	--	--
--	rs11547375^1,2	H	116579291(+)	`GGTGCC/GCGAGA`	2	P/R	mis¹ ese³		4		EU EA WA	356
--	rs45481399^1,2	F	116574260(+)	`CTCTTA/CTCTCT`	2	--	ng5¹		1		NS	40
--	rs1050490^1,2	A	116580472(+)	`AACTTC/TTTACC`	2	--	ut3¹		1		MN	184
	rs7112573^1,2	A	116574233(+)	`CCCACC/TGTTAG`	2	--	ng5¹		0	--	--	--	--
--	rs17523113^1,2	F	116575111(+)	`GCCCCG/AGTAGA`	2	--	ng5¹		2		MN EA	356

About this table

HapMap Linkage Disequilibrium images for TAGLN (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600818

9 Novoseek disease relationships for TAGLN gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
colon tumor	22.66	3	16402363 (2), 11773051 (1)
colon cancer	13.67	1	16402363 (1)
cancer	7.03	5	18446369 (3), 15547752 (1)
asthma	6.29	2	19011151 (2)
tumors	3.31	4	11503213 (1), 16645950 (1), 16051329 (1), 11773051 (1)
shock	0.00	4	12923326 (1), 15378762 (1), 16035116 (1), 16051329 (1)
cancer lung	0.00	1	15378762 (1)
prostate cancer	0.00	5	17082327 (3), 17267660 (1)
carcinoma squamous cell	0.00	1	16051329 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/127 PubMed articles for TAGLN gene (see all 127 ):

A novel gene encoding a smooth muscle protein is overexpressed in senescent human fibroblasts. (PubMed id 1520290)^{1, 2, 3, 4} Thweatt R....Goldstein S. (1992)
Expression and cytogenetic localization of the human SM22 gene (TAGLN). (PubMed id 9615232)^{1, 3, 4} Camoretti-Mercado B....Solway J. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Structure and expression of the human SM22alpha gene, assignment of the gene to chromosome 11, and repression of the promoter activity by cytosine DNA methylation. (PubMed id 9276683)^{3, 4} Yamamura H.... Takahashi K. (1997)
Purification, characterization, and partial sequence analysis of a new 25-kDa actin-binding protein from bovine aorta: a SM22 homolog. (PubMed id 8117285)^{2, 3} Kobayashi R....Hidaka H. (1994)
Gene cloning and nucleotide sequence of SM22 alpha from the chicken gizzard smooth muscle. (PubMed id 1872880)^{3, 4} Nishida W.... Kiwada K. (1991)
Mutagenesis analysis of human SM22: characterization of actin binding. (PubMed id 11053353)^{1, 3} Fu Y....Solway J. (2000)
Transgelin functions as a suppressor via inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth. (PubMed id 17082327)^{1, 3} Yang Z....Chang C. (2007)
Identification of transgelin as a potential novel biomarker for gastric adenocarcinoma based on proteomics technology. (PubMed id 18446369)^{1, 3} Huang Q....Lin X. (2008)
Crystal structure of human transgelin. (PubMed id 18291675)^{1, 3} Li M....Rao Z. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6876	HGNC: 11553	AceView: TAGLNandSIDT2	Ensembl:ENSG00000149591	euGenes: HUgn6876
ECgene: TAGLN	H-InvDB: TAGLN

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for TAGLN
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TAGLN:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TAGLN-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TAGLN		Antibodies for TAGLN
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TAGLN		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TAGLN)
	Antibodies (TAGLN)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (SM22 alpha)
	Antibodies (SM22 alpha)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for TAGLN

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TAGLN

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TAGLN Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for TAGLN

Summaries
for TAGLN

Genomic Location
for TAGLN

Proteins
for TAGLN

Protein Domains/
Families
for TAGLN

Gene Function
for TAGLN

Pathways & Interactions
for TAGLN

Drugs & Compounds
for TAGLN

Transcripts
for TAGLN

Expression
for TAGLN

Orthologs
for TAGLN

Paralogs
for TAGLN

SNPs/Variants
for TAGLN

Disorders & Mutations
for TAGLN

Medical News
for TAGLN

Publications
for TAGLN

Search for TAGLN

Genome Databases showing TAGLN

Other Databases showing TAGLN

Specialized Databases showing TAGLN

Licensable Technologies
for TAGLN

Services
for TAGLN

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TAGLN Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor TAGLN

Summariesfor TAGLN

Genomic Locationfor TAGLN

Proteinsfor TAGLN

Protein Domains/Familiesfor TAGLN

Gene Functionfor TAGLN

Pathways & Interactionsfor TAGLN

Drugs & Compoundsfor TAGLN

Transcriptsfor TAGLN

Expression for TAGLN

Orthologsfor TAGLN

Paralogsfor TAGLN

SNPs/Variantsfor TAGLN

Disorders & Mutationsfor TAGLN

Medical Newsfor TAGLN

Publicationsfor TAGLN

Search for TAGLN

Genome Databases showing TAGLN

Other Databases showing TAGLN

Specialized Databases showing TAGLN

Licensable Technologiesfor TAGLN

Servicesfor TAGLN

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TAGLN

Summaries
for TAGLN

Genomic Location
for TAGLN

Proteins
for TAGLN

Protein Domains/
Families
for TAGLN

Gene Function
for TAGLN

Pathways & Interactions
for TAGLN

Drugs & Compounds
for TAGLN

Transcripts
for TAGLN

Expression
for TAGLN

Orthologs
for TAGLN

Paralogs
for TAGLN

SNPs/Variants
for TAGLN

Disorders & Mutations
for TAGLN

Medical News
for TAGLN

Publications
for TAGLN

Licensable Technologies
for TAGLN

Services
for TAGLN