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TAGLN Gene

protein-coding   GIFtS: 66
GCID: GC11P117070

Transgelin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
transgelin1 2     22 KDa Actin-Binding Protein2 3
SM22-alpha1 2 3     WS3-102 3
SM222 3 5     SMCC2 5
Transgelin Variant 21 2     TAGLN12
Smooth Muscle Protein 22-Alpha2 3     Protein WS3-103

External Ids:    HGNC: 115531   Entrez Gene: 68762   Ensembl: ENSG000001495917   OMIM: 6008185   UniProtKB: Q019953   
ORGUL members:         

Export aliases for TAGLN gene to outside databases

Previous GC identifers: GC11P119422 GC11P118581 GC11P117103 GC11P116607 GC11P116575 GC11P113002


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TAGLN Gene:
The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling
protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this
down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this
protein is unclear. Two transcript variants encoding the same protein have been found for this gene. (provided by
RefSeq, Jul 2008)

GeneCards Summary for TAGLN Gene:
TAGLN (transgelin) is a protein-coding gene. Diseases associated with TAGLN include peyronie's disease, and peyronies disease. GO annotations related to this gene include actin binding. An important paralog of this gene is TAGLN2.

UniProtKB/Swiss-Prot: TAGL_HUMAN, Q01995
Function: Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile
properties of the cell that may contribute to replicative senescence

Gene Wiki entry for TAGLN Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the TAGLN gene promoter:
         Sp1   Nkx2-5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAGLN promoter sequence
   Search Chromatin IP Primers for TAGLN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAGLN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.2   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.2

TAGLN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAGLN gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P117070:  view genomic region     (about GC identifiers)

Start:
117,070,037 bp from pter      End:
117,075,508 bp from pter
Size:
5,472 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TAGL_HUMAN, Q01995 (See protein sequence)
Recommended Name: Transgelin  
Size: 201 amino acids; 22611 Da
Secondary accessions: O15542

Explore the universe of human proteins at neXtProt for TAGLN: NX_Q01995

Explore proteomics data for TAGLN at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TAGLN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001001522.1  NP_003177.2  

    ENSEMBL proteins: 
     ENSP00000376678   ENSP00000432054   ENSP00000278968   ENSP00000431862   ENSP00000431941  
     ENSP00000432282   ENSP00000432380  

    TAGLN Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals TAGLN Proteins
    Novus Biologicals TAGLN Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TAGLN
    Cloud-Clone Corp. Proteins for TAGLN

    TAGLN Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TAGLN
    R&D Systems Antibodies for TAGLN (Transgelin/TAGLN)
    OriGene Antibodies for TAGLN
    OriGene Custom Antibody Services for TAGLN
    Novus Biologicals TAGLN Antibodies
    Abcam antibodies for TAGLN
    Cloud-Clone Corp. Antibodies for TAGLN
    ThermoFisher Antibody for TAGLN
    LSBio Antibodies in human, mouse, rat for TAGLN

    TAGLN Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TAGLN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TAGLN
    Cloud-Clone Corp. CLIAs for TAGLN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001715 CH-domain
     IPR003096 SM22_calponin
     IPR000557 Calponin_repeat

    Graphical View of Domain Structure for InterPro Entry Q01995

    ProtoNet protein and cluster: Q01995

    3 Blocks protein domains:
    IPB001061 Smooth muscle protein 22-alpha (transgelin) signature
    IPB001715 Calponin-like actin-binding
    IPB003247 Calponin-like actin-binding subtype


    UniProtKB/Swiss-Prot: TAGL_HUMAN, Q01995
    Similarity: Belongs to the calponin family
    Similarity: Contains 1 calponin-like repeat
    Similarity: Contains 1 CH (calponin-homology) domain


    TAGLN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAGL_HUMAN, Q01995
    Function: Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile
    properties of the cell that may contribute to replicative senescence
    Induction: Overexpressed in senescent human fibroblasts

         Genatlas biochemistry entry for TAGLN:
    transgelin,22kDa,cytoplasmic,one of the earliest markers of differentiated smooth muscle cells and adult
    tissues,murine Sm22 alpha homolog,highly expressed in senescent fibroblasts and in fibroblasts from patients with
    Werner syndrome

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI--
         
    TAGLN for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TAGLN:
     Decreased viability with carbo 

         13 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Tagln):
     behavior/neurological  cardiovascular system  digestive/alimentary  growth/size/body  immune system 
     mortality/aging  muscle  nervous system  normal  renal/urinary system 
     reproductive system  skeleton  tumorigenesis 

    TAGLN for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TAGLN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TAGLN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TAGLN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TAGLN

    miRNA
    Products:
        
    miRTarBase miRNAs that target TAGLN:
    hsa-mir-26b-5p (MIRT030313), hsa-mir-128-3p (MIRT022018), hsa-mir-9-5p (MIRT021406), hsa-mir-7-5p (MIRT025891)

    Block miRNA regulation of human, mouse, rat TAGLN using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate TAGLN:
    hsa-miR-485-5p hsa-miR-22 hsa-miR-4316 hsa-miR-100* hsa-miR-539 hsa-miR-558 hsa-miR-143* hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmidTAGLN 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TAGLN
    Predesigned siRNA for gene silencing in human, mouse, rat TAGLN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TAGLN

    Clone
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    OriGene clones in human, mouse for TAGLN (see all 11)
    OriGene ORF clones in mouse, rat for TAGLN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TAGLN (NM_003186)
    Sino Biological Human cDNA Clone for TAGLN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAGLN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAGLN

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TAGLN
    ESI BIO PureStem Progenitors for TAGLN: 
    PureStem ES-210, Ecto-ntu Progenitor, PureStem Z11, Meso Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAGLN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TAGL_HUMAN, Q01995: Cytoplasm (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton3
    cytosol3
    extracellular2
    nucleus2
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    TAGLN for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including TAGLN: 
              Terminal Differentiation Markers in human mouse rat
              Wound Healing in human mouse rat
              Hepatotoxicity in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TAGLN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TAGLN (Q019951, 2, 3 ENSP000002789684) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IGF1RP080691, 2, ENSP000002680354EBI-1054248,EBI-475981 MINT-8301962 MINT-8301951 STRING: ENSP00000268035
    PRKCDQ056553, ENSP000003316024I2D: score=2 STRING: ENSP00000331602
    ACTA1P681333, ENSP000003556454I2D: score=3 STRING: ENSP00000355645
    AGR2O959943, ENSP000003914904I2D: score=1 STRING: ENSP00000391490
    CFL1P235283, ENSP000003096294I2D: score=2 STRING: ENSP00000309629
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007517muscle organ development TAS9615232
    GO:0030855epithelial cell differentiation IDA--

    TAGLN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TAGLN (TAGL)

    1 HMDB Compound for TAGLN    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected Novoseek inferred chemical compound relationships for TAGLN gene (see all 12)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tgf beta1 39.8 9 16876108 (3), 15217807 (2), 20368328 (1)
    glyceraldehyde 3-phosphate 31.7 5 15986332 (1), 19767541 (1), 17332923 (1), 11904414 (1)
    retinoic acid 10.7 4 18511453 (1), 19486889 (1)
    pyruvate 6.86 1 19767541 (1)
    phosphatidylinositol 3.65 1 16310342 (1)
    superoxide 1.94 4 16035116 (1), 19288589 (1), 15986332 (1), 17332923 (1)
    calcium 0 2 1520290 (1)
    tyrosine 0 1 14630650 (1)
    fatty acid 0 3 11716502 (1), 11904414 (1), 19082487 (1)
    arginine 0 1 12829429 (1)



    TAGLN for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TAGLN gene (2 alternative transcripts): 
    NM_001001522.1  NM_003186.3  

    Unigene Cluster for TAGLN:

    Transgelin
    Hs.410977  [show with all ESTs]
    Unigene Representative Sequence: AB209555
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392951 ENST00000525531 ENST00000278968(uc001pql.1 uc001pqm.3 uc001pqn.3)
    ENST00000529792 ENST00000533863 ENST00000530649(uc001pqo.3) ENST00000532870(uc001pqp.3)
    ENST00000529622
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TAGLN using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate TAGLN:
    hsa-miR-485-5p hsa-miR-22 hsa-miR-4316 hsa-miR-100* hsa-miR-539 hsa-miR-558 hsa-miR-143* hsa-miR-1827
    SwitchGear 3'UTR luciferase reporter plasmidTAGLN 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TAGLN
    Predesigned siRNA for gene silencing in human, mouse, rat TAGLN
    Clone
    Products:
         
    OriGene clones in human, mouse for TAGLN (see all 11)
    OriGene ORF clones in mouse, rat for TAGLN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TAGLN (NM_003186)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAGLN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAGLN
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TAGLN
    OriGene qSTAR qPCR primer pairs in human, mouse for TAGLN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TAGLN
      QuantiTect SYBR Green Assays in human, mouse, rat TAGLN
      QuantiFast Probe-based Assays in human, mouse, rat TAGLN

    Additional mRNA sequence: 

    AB209555.1 AK223002.1 AK314043.1 BC004927.1 BC010946.1 BC065829.1 BC092415.1 BC093050.1 
    BT019648.1 BT019649.1 BX640723.1 CR536484.1 CR541681.1 D17409.1 M83106.1 M95787.1 

    Selected DOTS entries (see all 51):

    DT.450977  DT.92461872  DT.100688943  DT.102840249  DT.100688949  DT.95332543  DT.100664339  DT.95333302 
    DT.92461860  DT.100688951  DT.100805934  DT.95162555  DT.100041913  DT.100688936  DT.100805938  DT.100871648 
    DT.421136  DT.95073168  DT.120753112  DT.120753132  DT.95207334  DT.100805943  DT.40278703  DT.95162477 

    Selected AceView cDNA sequences (see all 889):

    CA397259 BM970447 AI753691 BI754694 AI753279 CA420508 CR594882 AA374758 
    BU628758 BE673549 CR605812 BU844387 BX377865 AI066437 AI865746 BI826644 
    BU855466 BQ005936 AL560426 NM_001001522 AI082237 F05615 BU151707 BQ643590 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TAGLN (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e · 11f
    SP1:                    -     -     -     -     -     -           -                                                               
    SP2:                    -     -     -     -     -     -                                                                           
    SP3:                          -     -     -     -     -                                                                           
    SP4:                          -     -     -     -     -                                                                           
    SP5:                                            -     -                                                                           


    ECgene alternative splicing isoforms for TAGLN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TAGLN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACAGGCTACG
    TAGLN Expression
    About this image


    TAGLN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 37) fully expand
     
     Smooth Muscle (Muscoskeletal System)    fully expand to see all 23 entries
             Vascular Smooth Muscle Cells Aortic Arch Arteries
             Neo-Urinary Conduit
             Neuroectoderm-derived smooth muscle cells
             Coronary Artery Smooth Muscle Cells (CASMC)   
     
     Heart (Cardiovascular System)    fully expand to see all 8 entries
             Vascular Smooth Muscle Cells Aortic Arch Arteries
             Heart Tube
             Cardiomyocytes-like cells
             Coronary Artery Smooth Muscle Cells (CASMC)   
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Vascular Smooth Muscle Cells Splanchnic Mesoderm
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 4 entries
             Umbilical cord-derived mesenchymal stem cells (family)
             Human Umbillical Artery Smooth Muscle Cells (HUASMC)   
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Vascular Smooth Muscle Cells Veins
             Endothelial-like cells
    TAGLN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TAGLN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.410977
        Pathway & Disease-focused RT2 Profiler PCR Arrays including TAGLN: 
              Terminal Differentiation Markers in human mouse rat
              Wound Healing in human mouse rat
              Hepatotoxicity in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TAGLN
    OriGene qSTAR qPCR primer pairs in human, mouse for TAGLN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TAGLN
    QuantiTect SYBR Green Assays in human, mouse, rat TAGLN
    QuantiFast Probe-based Assays in human, mouse, rat TAGLN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAGLN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TAGLN gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tagln1 , 5 transgelin1, 5 91.04(n)1
    97.01(a)1
      9 (25.36 cM)5
    213451  NM_011526.51  NP_035656.11 
     459296285 
    chicken
    (Gallus gallus)
    Aves TAGLN1 transgelin 82.83(n)
    86.5(a)
      396490  NM_205494.1  NP_990825.1 
    lizard
    (Anolis carolinensis)
    Reptilia TAGLN6
    transgelin
    72(a)
    1 ↔ 1
    GL343949.1(98090-104039)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC685502 hypothetical protein MGC68550 78.23(n)    BC061650.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.206022 Transcribed sequence with moderate similarity to protein more 74.57(n)    BI846015.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG50236
    --
    34(a)
    many ↔ many
    3R(15995158-16000597)
    worm
    (Caenorhabditis elegans)
    Secernentea cpn-26
    Protein CPN-2 (cpn-2) mRNA, complete cds
    37(a)
    1 → many
    II(337339-339248) WBGene00000778
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SCP16
    Component of yeast cortical actin cytoskeleton, bi...
    24(a)
    1 → many
    XV(1026007-1026609) YOR367W


    ENSEMBL Gene Tree for TAGLN (if available)
    TreeFam Gene Tree for TAGLN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TAGLN gene
    TAGLN22  CNN12  CNN32  TAGLN32  CNN22  
    5 SIMAP similar genes for TAGLN using alignment to 6 protein entries:     TAGL_HUMAN (see all proteins):
    TAGLN2    TAGLN3    CNN3    CNN1    CNN2

    TAGLN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TAGLN (see all 31)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1475149011,2
    --117074760(+) CCTCCC/TTTTCC 2 -- int10--------
    rs1904064531,2
    --117074815(+) TAGGGA/GAAAAA 2 -- int10--------
    rs1132782371,2
    C,F--117074825(+) AAGTGC/AAACAG 2 -- int12Minor allele frequency- A:0.04CSA WA 119
    rs1385164211,2
    --117074876(+) GAAAAC/TGGGTG 2 -- int10--------
    rs1126760201,2
    C--117074928(+) TCTTCG/TAGGAA 2 -- int10--------
    rs1128768831,2
    C--117074930(+) TTCTAA/GGAAAG 2 -- spa10--------
    rs2012433441,2
    --117074945(+) GGAGCA/GTAAGA 4 H R mis10--------
    rs1430225701,2
    C,F--117075003(+) CTTCAG/TATGGG 4 Q H mis12Minor allele frequency- T:0.00NA EU 5871
    rs1995611581,2
    C--117075008(+) GATGGG/ACAGCA 4 /D /G mis11Minor allele frequency- A:0.00EU 1321
    rs122843161,2,,4
    C,F,H--117075014(+) CAGCAA/GCAGAG 4 N S mis1 ese38Minor allele frequency- G:0.00NS NA 5400

    HapMap Linkage Disequilibrium report for TAGLN (117070037 - 117075508 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TAGLN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv524270CNV Loss19592680
    nsv7223OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TAGLN
    DNA2.0 Custom Variant and Variant Library Synthesis for TAGLN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600818    OMIM disorders: --

    Selected diseases for TAGLN (see all 40):    
    About MalaCards
    peyronie's disease    peyronies disease    barrett's adenocarcinoma    werner syndrome
    t cell deficiency    schistosomiasis    keloids    rheumatic disease
    small cell carcinoma    gastric adenocarcinoma    liver cirrhosis    endometriosis
    glomerulonephritis    aortic aneurysm    ulcerative colitis    osteoarthritis
    sinusitis    asthma    colorectal cancer    retinoblastoma

    1 disease from the University of Copenhagen DISEASES database for TAGLN:
    Small cell carcinoma

    TAGLN for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for TAGLN gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon tumor 18.7 3 16402363 (2), 11773051 (1)
    colorectal cancer 17.1 9 19329940 (5)
    cancer 9.63 10 18446369 (3), 19711377 (1), 19848416 (1), 15547752 (1)
    colon cancer 8.84 1 16402363 (1)
    asthma 6.81 2 19011151 (2)
    prostate cancer 6.56 10 20012321 (5), 17082327 (3), 17267660 (1)
    tumors 5.14 9 19329940 (1), 11503213 (1), 16645950 (1), 19771267 (1) (see all 7)
    shock 4.01 5 12923326 (1), 15378762 (1), 16035116 (1), 19771267 (1) (see all 5)
    carcinoma squamous cell 0 2 19771267 (1), 16051329 (1)
    cancer lung 0 1 15378762 (1)

    Genetic Association Database (GAD): TAGLN
    Human Genome Epidemiology (HuGE) Navigator: TAGLN (6 documents)

    Export disorders for TAGLN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TAGLN gene, integrated from 10 sources (see all 169):
    (articles sorted by number of sources associating them with TAGLN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel gene encoding a smooth muscle protein is overexpressed in senescent human fibroblasts. (PubMed id 1520290)1, 2, 3, 9 Thweatt R.... Goldstein S. (Biochem. Biophys. Res. Commun. 1992)
    2. Expression and cytogenetic localization of the human SM22 gene (TAGLN). (PubMed id 9615232)1, 2, 9 Camoretti-Mercado B....Solway J. (Genomics 1998)
    3. Screening the single nucleotide polymorphisms in patients with internal carotid artery stenosis by oligonucleotide-based custom DNA array. (PubMed id 20066125)1, 4, 9 Nakai K....Ogawa A. (Bioinform Biol Insights 2009)
    4. Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits. (PubMed id 21943158)1, 4 Middelberg R.P....Whitfield J.B. (BMC Med. Genet. 2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. [A study of the single nucleotide polymorphism in seven genes (GHR, IGFBP3, IGFR1, IRS1, FMN1, ANXA2, TaGLN) in ethnic Russians and in patients with prostate cancer]. (PubMed id 20540360)1, 4 Lisitskaia K.V....Shishkin S.S. (Mol. Gen. Mikrobiol. Virusol. 2010)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Structure and expression of the human SM22alpha gene, assignment of the gene to chromosome 11, and repression of the promoter activity by cytosine DNA methylation. (PubMed id 9276683)1, 2 Yamamura H.... Takahashi K. (J. Biochem. 1997)
    10. Purification, characterization, and partial sequence analysis of a new 25-kDa actin-binding protein from bovine aorta: a SM22 homolog. (PubMed id 8117285)1, 3 Kobayashi R....Hidaka H. (Biochem. Biophys. Res. Commun. 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6876 HGNC: 11553 AceView: TAGLNandSIDT2 Ensembl:ENSG00000149591 euGenes: HUgn6876
    ECgene: TAGLN H-InvDB: TAGLN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TAGLN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TAGLN Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TAGLN gene:
    Search GeneIP for patents involving TAGLN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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