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Aliases for TAGLN Gene

Aliases for TAGLN Gene

  • Transgelin 2 3 3 5
  • SM22-Alpha 2 3 4
  • Smooth Muscle Protein 22-Alpha 3 4
  • 22 KDa Actin-Binding Protein 3 4
  • Transgelin Variant 2 2 3
  • WS3-10 3 4
  • SM22 3 4
  • Protein WS3-10 4
  • TAGLN1 3
  • SMCC 3

External Ids for TAGLN Gene

Previous GeneCards Identifiers for TAGLN Gene

  • GC11P119422
  • GC11P118581
  • GC11P117103
  • GC11P116607
  • GC11P116575
  • GC11P117070
  • GC11P113002

Summaries for TAGLN Gene

Entrez Gene Summary for TAGLN Gene

  • This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization. [provided by RefSeq, Aug 2017]

GeneCards Summary for TAGLN Gene

TAGLN (Transgelin) is a Protein Coding gene. Diseases associated with TAGLN include Laryngeal Small Cell Carcinoma and Gastric Small Cell Carcinoma. GO annotations related to this gene include actin binding and actin filament binding. An important paralog of this gene is TAGLN3.

UniProtKB/Swiss-Prot for TAGLN Gene

  • Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.

Gene Wiki entry for TAGLN Gene

Additional gene information for TAGLN Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAGLN Gene

Genomics for TAGLN Gene

Regulatory Elements for TAGLN Gene

Enhancers for TAGLN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H117173 0.8 ENCODE dbSUPER 37.7 -24.5 -24452 1.8 ZNF362 JUND EGR1 ZSCAN4 ZNF7 TAGLN LOC653303 PAFAH1B2 ENSG00000254678 RNF214 PCSK7 ZPR1 APOA5 SIDT2
GH11H116825 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.7 -365.9 -365916 16.6 HDGF PKNOX1 FOXA2 MLX ARID4B DMAP1 ZNF2 YY1 SLC30A9 ZNF143 APOA5 APOA1 LOC653303 APOC3 TAGLN ZPR1 BUD13 ENSG00000226645 ENSG00000224077 SIK3
GH11H117070 1.6 Ensembl ENCODE dbSUPER 10.8 -126.6 -126620 3.6 PKNOX1 FOXA2 MLX ARNT ARID4B FEZF1 YY1 ZNF766 FOS SP3 SIK3 LOC653303 ENSG00000224077 TAGLN APOA1 GC11M117070
GH11H116732 1 Ensembl ENCODE 17.1 -466.6 -466648 1 HDGF CTCF PKNOX1 MAX RAD21 RELA TEAD3 EED SMC3 ZNF143 TAGLN PCSK7 BUD13 ENSG00000226645 APOA5 ZPR1 LOC653303 GC11M116662
GH11H116978 1.5 FANTOM5 Ensembl ENCODE dbSUPER 10.8 -218.5 -218477 4 CEBPB MAX ELF1 DPF2 NBN ETV6 MLLT1 ATF7 RUNX3 IKZF2 LOC653303 SIK3 APOA1 ENSG00000224077 TAGLN GC11P117017
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAGLN on UCSC Golden Path with GeneCards custom track

Promoters for TAGLN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000045484 779 2201 ELK4 CTCF MAZ CHD1 ZNF195 ZNF398 ZIC2 GLIS2 POLR2A GLIS1

Transcription factor binding sites by QIAGEN in the TAGLN gene promoter:

Genomic Locations for TAGLN Gene

Genomic Locations for TAGLN Gene
5,472 bases
Plus strand

Genomic View for TAGLN Gene

Genes around TAGLN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAGLN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAGLN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAGLN Gene

Proteins for TAGLN Gene

  • Protein details for TAGLN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • O15542

    Protein attributes for TAGLN Gene

    201 amino acids
    Molecular mass:
    22611 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TAGLN Gene

Post-translational modifications for TAGLN Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for TAGLN (Transgelin/TAGLN)

No data available for DME Specific Peptides for TAGLN Gene

Domains & Families for TAGLN Gene

Gene Families for TAGLN Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the calponin family.
  • Belongs to the calponin family.
genes like me logo Genes that share domains with TAGLN: view

Function for TAGLN Gene

Molecular function for TAGLN Gene

GENATLAS Biochemistry:
transgelin,22kDa,cytoplasmic,one of the earliest markers of differentiated smooth muscle cells and adult tissues,murine Sm22 alpha homolog,highly expressed in senescent fibroblasts and in fibroblasts from patients with Werner syndrome
UniProtKB/Swiss-Prot Function:
Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.
UniProtKB/Swiss-Prot Induction:
Overexpressed in senescent human fibroblasts.

Phenotypes From GWAS Catalog for TAGLN Gene

Gene Ontology (GO) - Molecular Function for TAGLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21044950
GO:0051015 actin filament binding IEA --
genes like me logo Genes that share ontologies with TAGLN: view
genes like me logo Genes that share phenotypes with TAGLN: view

Animal Models for TAGLN Gene

MGI Knock Outs for TAGLN:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAGLN Gene

Localization for TAGLN Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAGLN Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAGLN gene
Compartment Confidence
cytosol 4
cytoskeleton 3
extracellular 2
nucleus 2
plasma membrane 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Microtubules (2)
  • Mitochondria (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TAGLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TAGLN: view

Pathways & Interactions for TAGLN Gene

SuperPathways for TAGLN Gene

No Data Available

SIGNOR curated interactions for TAGLN Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TAGLN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007517 muscle organ development TAS 9615232
GO:0030855 epithelial cell differentiation IDA 21492153
genes like me logo Genes that share ontologies with TAGLN: view

No data available for Pathways by source for TAGLN Gene

Drugs & Compounds for TAGLN Gene

(6) Drugs for TAGLN Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(6) Additional Compounds for TAGLN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TAGLN: view

Transcripts for TAGLN Gene

Unigene Clusters for TAGLN Gene

Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAGLN Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c · 11d · 11e · 11f
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - -
SP6: -
SP7: - - - - - - - -
SP9: - - - -

Relevant External Links for TAGLN Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TAGLN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAGLN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TAGLN Gene

This gene is overexpressed in Artery - Tibial (x6.0), Artery - Coronary (x5.5), Artery - Aorta (x5.1), Esophagus - Muscularis (x4.4), and Colon - Sigmoid (x4.4).

Protein differential expression in normal tissues from HIPED for TAGLN Gene

This gene is overexpressed in Seminal vesicle (10.8), Cardia (10.3), Colon muscle (7.6), and Prostate (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TAGLN Gene

Protein tissue co-expression partners for TAGLN Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TAGLN Gene:


SOURCE GeneReport for Unigene cluster for TAGLN Gene:


Evidence on tissue expression from TISSUES for TAGLN Gene

  • Liver(4.5)
  • Lung(4.5)
  • Nervous system(4.5)
  • Intestine(4.4)
  • Blood(4.3)
  • Muscle(4)
  • Eye(3.9)
  • Pancreas(3.9)
  • Skin(3.9)
  • Bone(3.7)
  • Stomach(3.4)
  • Heart(3.3)
  • Kidney(3.1)
  • Gall bladder(2.8)
  • Lymph node(2.7)
  • Adrenal gland(2.4)
  • Spleen(2.2)
genes like me logo Genes that share expression patterns with TAGLN: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAGLN Gene

Orthologs for TAGLN Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAGLN Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TAGLN 33 34
  • 99.67 (n)
(Monodelphis domestica)
Mammalia TAGLN 34
  • 97 (a)
(Bos Taurus)
Mammalia TAGLN 33 34
  • 93.7 (n)
(Canis familiaris)
Mammalia TAGLN 33 34
  • 92.7 (n)
(Rattus norvegicus)
Mammalia Tagln 33
  • 91.71 (n)
(Mus musculus)
Mammalia Tagln 33 16 34
  • 91.04 (n)
(Gallus gallus)
Aves TAGLN 33 34
  • 82.83 (n)
(Anolis carolinensis)
Reptilia TAGLN 34
  • 72 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tagln 33
  • 73.96 (n)
Str.5784 33
African clawed frog
(Xenopus laevis)
Amphibia MGC68550 33
(Danio rerio)
Actinopterygii tagln 33 34
  • 73.23 (n)
tagln2 34
  • 69 (a)
Dr.20602 33
fruit fly
(Drosophila melanogaster)
Insecta CG5023 34
  • 34 (a)
(Caenorhabditis elegans)
Secernentea cpn-2 34
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCP1 34
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
CSA.10356 34
  • 36 (a)
-- 34
  • 34 (a)
Species where no ortholog for TAGLN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAGLN Gene

Gene Tree for TAGLN (if available)
Gene Tree for TAGLN (if available)

Paralogs for TAGLN Gene

Paralogs for TAGLN Gene

(5) SIMAP similar genes for TAGLN Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TAGLN: view

Variants for TAGLN Gene

Sequence variations from dbSNP and Humsavar for TAGLN Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000988515 -- 117,204,965(+) AGGCC(A/G)TAGAA downstream-variant-500B
rs1000992923 -- 117,200,462(+) CATGC(C/T)TGTCC intron-variant
rs1002998544 -- 117,198,526(+) CTCTT(A/G)TTGAC intron-variant, upstream-variant-2KB
rs1003024284 -- 117,201,730(+) TCCCG(C/T)GGGTG intron-variant
rs1003877206 -- 117,201,818(+) TCCCT(C/T)CCAAC intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for TAGLN Gene

Variant ID Type Subtype PubMed ID
nsv7223 OTHER inversion 18451855
nsv524270 CNV loss 19592680
nsv1078301 OTHER inversion 25765185
dgv730n106 OTHER inversion 24896259
dgv2186n54 CNV loss 21841781

Variation tolerance for TAGLN Gene

Residual Variation Intolerance Score: 57.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.09; 38.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAGLN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAGLN Gene

Disorders for TAGLN Gene

MalaCards: The human disease database

(5) MalaCards diseases for TAGLN Gene - From: DISEASES

Disorder Aliases PubMed IDs
laryngeal small cell carcinoma
  • small cell carcinoma of larynx
gastric small cell carcinoma
  • small cell carcinoma of stomach
cervix small cell carcinoma
  • small cell carcinoma of the cervix
retinitis pigmentosa 26
  • rp26
malignant fibrous histiocytoma of bone
  • malignant fibrous histiocytoma of the bone
- elite association - COSMIC cancer census association via MalaCards
Search TAGLN in MalaCards View complete list of genes associated with diseases

Relevant External Links for TAGLN

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TAGLN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAGLN Gene

Publications for TAGLN Gene

  1. A novel gene encoding a smooth muscle protein is overexpressed in senescent human fibroblasts. (PMID: 1520290) Thweatt R … Goldstein S (Biochemical and biophysical research communications 1992) 2 3 4 22 60
  2. Screening the single nucleotide polymorphisms in patients with internal carotid artery stenosis by oligonucleotide-based custom DNA array. (PMID: 20066125) Nakai K … Ogawa A (Bioinformatics and biology insights 2009) 3 22 45 60
  3. Expression and cytogenetic localization of the human SM22 gene (TAGLN). (PMID: 9615232) Camoretti-Mercado B … Solway J (Genomics 1998) 3 4 22 60
  4. Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits. (PMID: 21943158) Middelberg RP … Whitfield JB (BMC medical genetics 2011) 3 45 60
  5. Expression of the actin-associated protein transgelin (SM22) is decreased in prostate cancer. (PMID: 20012321) Prasad PD … Assinder SJ (Cell and tissue research 2010) 3 22 60

Products for TAGLN Gene

Sources for TAGLN Gene

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