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Aliases for TAGAP Gene

Aliases for TAGAP Gene

  • T-Cell Activation RhoGTPase Activating Protein 2 3 5
  • TAGAP1 3 4
  • T-Cell Activation GTPase Activating Protein 2
  • T-Cell Activation GTPase-Activating Protein 4
  • ARHGAP47 3
  • FKSG15 3
  • IDDM21 3

External Ids for TAGAP Gene

Previous GeneCards Identifiers for TAGAP Gene

  • GC06M158897
  • GC06M159329
  • GC06M159365
  • GC06M159426
  • GC06M159375
  • GC06M159457
  • GC06M156926

Summaries for TAGAP Gene

Entrez Gene Summary for TAGAP Gene

  • This gene encodes a member of the Rho GTPase-activator protein superfamily. The encoded protein may function as a Rho GTPase-activating protein. Alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disease, and multiple sclerosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]

GeneCards Summary for TAGAP Gene

TAGAP (T-Cell Activation RhoGTPase Activating Protein) is a Protein Coding gene. Diseases associated with TAGAP include Diabetes Mellitus, Insulin-Dependent, 21 and Auditory Agnosia. Among its related pathways are Signaling by Rho GTPases and Signaling by GPCR. GO annotations related to this gene include guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGAP20.

UniProtKB/Swiss-Prot for TAGAP Gene

  • May function as a GTPase-activating protein and may play important roles during T-cell activation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAGAP Gene

Genomics for TAGAP Gene

Regulatory Elements for TAGAP Gene

Enhancers for TAGAP Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TAGAP on UCSC Golden Path with GeneCards custom track

Promoters for TAGAP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TAGAP on UCSC Golden Path with GeneCards custom track

Genomic Location for TAGAP Gene

159,034,468 bp from pter
159,045,152 bp from pter
10,685 bases
Minus strand

Genomic View for TAGAP Gene

Genes around TAGAP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAGAP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAGAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAGAP Gene

Proteins for TAGAP Gene

  • Protein details for TAGAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    T-cell activation Rho GTPase-activating protein
    Protein Accession:
    Secondary Accessions:
    • Q2NKM8
    • Q8NI40
    • Q96KZ2
    • Q96QA2

    Protein attributes for TAGAP Gene

    731 amino acids
    Molecular mass:
    80703 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TAGAP Gene


neXtProt entry for TAGAP Gene

Proteomics data for TAGAP Gene at MOPED

Post-translational modifications for TAGAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAGAP Gene

Antibody Products

  • Abcam antibodies for TAGAP

No data available for DME Specific Peptides for TAGAP Gene

Domains & Families for TAGAP Gene

Gene Families for TAGAP Gene

Protein Domains for TAGAP Gene

Suggested Antigen Peptide Sequences for TAGAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Rho-GAP domain.
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with TAGAP: view

Function for TAGAP Gene

Molecular function for TAGAP Gene

UniProtKB/Swiss-Prot Function:
May function as a GTPase-activating protein and may play important roles during T-cell activation.
genes like me logo Genes that share phenotypes with TAGAP: view

Animal Models for TAGAP Gene

MGI Knock Outs for TAGAP:

Animal Model Products

miRNA for TAGAP Gene

miRTarBase miRNAs that target TAGAP

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAGAP Gene

Localization for TAGAP Gene

Subcellular locations from

Jensen Localization Image for TAGAP Gene COMPARTMENTS Subcellular localization image for TAGAP gene
Compartment Confidence
cytosol 5
nucleus 3
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TAGAP Gene

Pathways & Interactions for TAGAP Gene

genes like me logo Genes that share pathways with TAGAP: view

Pathways by source for TAGAP Gene

Interacting Proteins for TAGAP Gene

Gene Ontology (GO) - Biological Process for TAGAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with TAGAP: view

No data available for SIGNOR curated interactions for TAGAP Gene

Drugs & Compounds for TAGAP Gene

No Compound Related Data Available

Transcripts for TAGAP Gene

Unigene Clusters for TAGAP Gene

T-cell activation RhoGTPase activating protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAGAP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - -
SP6: - - -
SP7: -

Relevant External Links for TAGAP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TAGAP Gene

mRNA expression in normal human tissues for TAGAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TAGAP Gene

This gene is overexpressed in Whole Blood (x27.2) and Spleen (x4.4).

Protein differential expression in normal tissues from HIPED for TAGAP Gene

This gene is overexpressed in Heart (30.8), Peripheral blood mononuclear cells (21.3), Blymphocyte (6.6), and Platelet (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TAGAP Gene

SOURCE GeneReport for Unigene cluster for TAGAP Gene Hs.529984

genes like me logo Genes that share expression patterns with TAGAP: view

Protein tissue co-expression partners for TAGAP Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TAGAP Gene

Orthologs for TAGAP Gene

This gene was present in the common ancestor of animals.

Orthologs for TAGAP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TAGAP 35
  • 73.82 (n)
  • 67.18 (a)
  • 67 (a)
(Canis familiaris)
Mammalia TAGAP 35
  • 79.35 (n)
  • 74.27 (a)
  • 75 (a)
(Mus musculus)
Mammalia Tagap 35
  • 75.94 (n)
  • 69.24 (a)
Tagap 16
1700006A11Rik 36
  • 22 (a)
Gm1527 36
  • 15 (a)
Tagap 36
  • 68 (a)
Tagap1 36
  • 53 (a)
(Pan troglodytes)
Mammalia TAGAP 35
  • 99.45 (n)
  • 99.45 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Tagap 35
  • 75.94 (n)
  • 69.94 (a)
(Monodelphis domestica)
Mammalia TAGAP 36
  • 42 (a)
(Ornithorhynchus anatinus)
Mammalia TAGAP 36
  • 50 (a)
(Gallus gallus)
Aves TAGAP 35
  • 59.21 (n)
  • 49.56 (a)
  • 46 (a)
(Anolis carolinensis)
Reptilia TAGAP 36
  • 43 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tagap 35
  • 54.29 (n)
  • 46.35 (a)
(Danio rerio)
Actinopterygii tagapb 35
  • 46.09 (n)
  • 36.14 (a)
arhgap20 36
  • 16 (a)
tagapa 36
  • 28 (a)
tagapb 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea rga-2 36
  • 8 (a)
Species with no ortholog for TAGAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAGAP Gene

Gene Tree for TAGAP (if available)
Gene Tree for TAGAP (if available)

Paralogs for TAGAP Gene

Paralogs for TAGAP Gene

(1) SIMAP similar genes for TAGAP Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TAGAP: view

Variants for TAGAP Gene

Sequence variations from dbSNP and Humsavar for TAGAP Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_049146 -

Structural Variations from Database of Genomic Variants (DGV) for TAGAP Gene

Variant ID Type Subtype PubMed ID
nsv886798 CNV Gain 21882294

Variation tolerance for TAGAP Gene

Residual Variation Intolerance Score: 50.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.65; 45.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAGAP Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAGAP Gene

Disorders for TAGAP Gene

MalaCards: The human disease database

(5) MalaCards diseases for TAGAP Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
diabetes mellitus, insulin-dependent, 21
auditory agnosia
celiac disease
  • celiac sprue
anus disease
  • anal disease
rheumatoid arthritis
  • rheumatoid arthritis, progression of
- elite association - COSMIC cancer census association via MalaCards
Search TAGAP in MalaCards View complete list of genes associated with diseases

Relevant External Links for TAGAP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TAGAP: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAGAP Gene

Publications for TAGAP Gene

  1. Newly identified genetic risk variants for celiac disease related to the immune response. (PMID: 18311140) Hunt K.A. … van Heel D.A. (Nat. Genet. 2008) 2 3 48 67
  2. Identification of dysregulated genes in lymphocytes from children with Down syndrome. (PMID: 18356936) Sommer C.A. … Henrique-Silva F. (Genome 2008) 2 3
  3. Induction of RhoGAP and pathological changes characteristic of Alzheimer's disease by UAHFEMF discharge in rat brain. (PMID: 16375659) Chang I.F. … Hsiao H.Y. (Curr Alzheimer Res 2005) 2 3
  4. T-cell activation Rho GTPase-activating protein expression varies with inflammation location and severity in Crohn's disease. (PMID: 24582067) Connelly T.M. … Koltun W.A. (J. Surg. Res. 2014) 3
  5. Genome-wide interaction study of smoking and bladder cancer risk. (PMID: 24662972) Figueroa J.D. … Silverman D.T. (Carcinogenesis 2014) 3

Products for TAGAP Gene

Sources for TAGAP Gene