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Aliases for TAGAP Gene

Aliases for TAGAP Gene

  • T-Cell Activation RhoGTPase Activating Protein 2 3
  • TAGAP1 3 4
  • T-Cell Activation Rho GTPase-Activating Protein 3
  • T-Cell Activation GTPase Activating Protein 2
  • T-Cell Activation GTPase-Activating Protein 4
  • ARHGAP47 3
  • FKSG15 3
  • IDDM21 3

External Ids for TAGAP Gene

Previous GeneCards Identifiers for TAGAP Gene

  • GC06M158897
  • GC06M159329
  • GC06M159365
  • GC06M159426
  • GC06M159375
  • GC06M159457
  • GC06M156926

Summaries for TAGAP Gene

Entrez Gene Summary for TAGAP Gene

  • This gene encodes a member of the Rho GTPase-activator protein superfamily. The encoded protein may function as a Rho GTPase-activating protein. Alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disease, and multiple sclerosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]

GeneCards Summary for TAGAP Gene

TAGAP (T-Cell Activation RhoGTPase Activating Protein) is a Protein Coding gene. Diseases associated with TAGAP include auditory agnosia and agnosia. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. GO annotations related to this gene include guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGAP20.

UniProtKB/Swiss-Prot for TAGAP Gene

  • May function as a GTPase-activating protein and may play important roles during T-cell activation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAGAP Gene

Genomics for TAGAP Gene

Regulatory Elements for TAGAP Gene

Genomic Location for TAGAP Gene

Start:
159,034,468 bp from pter
End:
159,045,152 bp from pter
Size:
10,685 bases
Orientation:
Minus strand

Genomic View for TAGAP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAGAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAGAP Gene

Proteins for TAGAP Gene

  • Protein details for TAGAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N103-TAGAP_HUMAN
    Recommended name:
    T-cell activation Rho GTPase-activating protein
    Protein Accession:
    Q8N103
    Secondary Accessions:
    • Q2NKM8
    • Q8NI40
    • Q96KZ2
    • Q96QA2

    Protein attributes for TAGAP Gene

    Size:
    731 amino acids
    Molecular mass:
    80703 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TAGAP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAGAP Gene

Proteomics data for TAGAP Gene at MOPED

Post-translational modifications for TAGAP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAGAP Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TAGAP Gene

Domains for TAGAP Gene

Gene Families for TAGAP Gene

HGNC:
  • ARHGAP :Rho GTPase activating proteins

Protein Domains for TAGAP Gene

Suggested Antigen Peptide Sequences for TAGAP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N103

UniProtKB/Swiss-Prot:

TAGAP_HUMAN :
  • Q8N103
Domain:
  • Contains 1 Rho-GAP domain.
genes like me logo Genes that share domains with TAGAP: view

Function for TAGAP Gene

Molecular function for TAGAP Gene

UniProtKB/Swiss-Prot Function: May function as a GTPase-activating protein and may play important roles during T-cell activation.

Gene Ontology (GO) - Molecular Function for TAGAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with TAGAP: view

Phenotypes for TAGAP Gene

MGI mutant phenotypes for TAGAP:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with TAGAP: view

Animal Models for TAGAP Gene

MGI Knock Outs for TAGAP:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAGAP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TAGAP Gene

Localization for TAGAP Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAGAP Gene COMPARTMENTS Subcellular localization image for TAGAP gene
Compartment Confidence
cytosol 4
nucleus 3
extracellular 1

Gene Ontology (GO) - Cellular Components for TAGAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TAGAP: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TAGAP Gene

Pathways for TAGAP Gene

genes like me logo Genes that share pathways with TAGAP: view

Pathways by source for TAGAP Gene

Interacting Proteins for TAGAP Gene

Gene Ontology (GO) - Biological Process for TAGAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with TAGAP: view

Transcripts for TAGAP Gene

Unigene Clusters for TAGAP Gene

T-cell activation RhoGTPase activating protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAGAP

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TAGAP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAGAP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11
SP1: - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: - - -
SP5: - - -
SP6: - - -
SP7: -
SP8:
SP9:

Relevant External Links for TAGAP Gene

GeneLoc Exon Structure for
TAGAP
ECgene alternative splicing isoforms for
TAGAP

Expression for TAGAP Gene

mRNA expression in normal human tissues for TAGAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TAGAP Gene

This gene is overexpressed in Whole Blood (27.2) and Spleen (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TAGAP Gene

SOURCE GeneReport for Unigene cluster for TAGAP Gene Hs.529984

genes like me logo Genes that share expressions with TAGAP: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TAGAP Gene

Orthologs for TAGAP Gene

This gene was present in the common ancestor of animals.

Orthologs for TAGAP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAGAP 35
  • 99.45 (n)
  • 99.45 (a)
TAGAP 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAGAP 35
  • 73.82 (n)
  • 67.18 (a)
TAGAP 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAGAP 35
  • 79.35 (n)
  • 74.27 (a)
TAGAP 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700006A11Rik 36
  • 22 (a)
OneToMany
Gm1527 36
  • 15 (a)
OneToMany
Tagap 35
  • 75.94 (n)
  • 69.24 (a)
Tagap 16
Tagap 36
  • 68 (a)
OneToMany
Tagap1 36
  • 53 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia TAGAP 36
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAGAP 36
  • 50 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tagap 35
  • 75.94 (n)
  • 69.94 (a)
chicken
(Gallus gallus)
Aves TAGAP 35
  • 59.21 (n)
  • 49.56 (a)
TAGAP 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAGAP 36
  • 43 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tagap 35
  • 54.29 (n)
  • 46.35 (a)
zebrafish
(Danio rerio)
Actinopterygii arhgap20 36
  • 16 (a)
OneToMany
tagapa 36
  • 28 (a)
OneToMany
tagapb 35
  • 46.09 (n)
  • 36.14 (a)
tagapb 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rga-2 36
  • 8 (a)
OneToMany
Species with no ortholog for TAGAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAGAP Gene

ENSEMBL:
Gene Tree for TAGAP (if available)
TreeFam:
Gene Tree for TAGAP (if available)

Paralogs for TAGAP Gene

Paralogs for TAGAP Gene

Selected SIMAP similar genes for TAGAP Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TAGAP: view

Variants for TAGAP Gene

Sequence variations from dbSNP and Humsavar for TAGAP Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs365512 -- 159,038,294(-) TCCTC(A/C)CCTCC intron-variant
rs380885 -- 159,046,319(+) TAACT(C/T)AGCGG upstream-variant-2KB
rs441555 -- 159,038,301(+) AGGAA(A/G)AATGG intron-variant
rs926657 -- 159,042,420(-) GGTTG(A/G)TTTTT upstream-variant-2KB, intron-variant
rs1054751 -- 159,034,745(-) AGAAA(A/G)ATGTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TAGAP Gene

Variant ID Type Subtype PubMed ID
nsv886798 CNV Gain 21882294

Relevant External Links for TAGAP Gene

HapMap Linkage Disequilibrium report
TAGAP
Human Gene Mutation Database (HGMD)
TAGAP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAGAP Gene

Disorders for TAGAP Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for TAGAP Gene including...

Search for TAGAP Gene in MalaCards »

(2) University of Copenhagen DISEASES for TAGAP Gene

Relevant External Links for TAGAP

Genetic Association Database (GAD)
TAGAP
Human Genome Epidemiology (HuGE) Navigator
TAGAP
genes like me logo Genes that share disorders with TAGAP: view

No data available for UniProtKB/Swiss-Prot for TAGAP Gene

Publications for TAGAP Gene

  1. Newly identified genetic risk variants for celiac disease related to the immune response. (PMID: 18311140) Hunt K.A. … van Heel D.A. (Nat. Genet. 2008) 2 3 48
  2. Identification of dysregulated genes in lymphocytes from children with Down syndrome. (PMID: 18356936) Sommer C.A. … Henrique-Silva F. (Genome 2008) 2 3
  3. Six new coeliac disease loci replicated in an Italian population confirm association with coeliac disease. (PMID: 18805825) Romanos J. … Wijmenga C. (J. Med. Genet. 2009) 3 48
  4. Shared and distinct genetic variants in type 1 diabetes and celiac disease. (PMID: 19073967) Smyth D.J. … Todd J.A. (N. Engl. J. Med. 2008) 3 48
  5. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48

Products for TAGAP Gene

Sources for TAGAP Gene

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