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TAF9B Gene

protein-coding   GIFtS: 54

GC0XM077271
TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
(Previous names: TAF9-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31 kD, TAF9-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: TAF9L)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
DN-7 1, 2, 3
DN7 1, 2
OTTHUMP00000023594 2
TAF9L 2, 3, 5
TAFII31L 1, 2, 5
TFIID-31 1, 2
Descriptions
Neuronal cell death-related protein 7 3
TAF9-like RNA polymerase II, TATA box binding protein
(TBP)-associated factor, 31 kD 1, 2
TAF9-like RNA polymerase II, TATA box binding protein
(TBP)-associated factor, 31kDa 1, 2
TAF9B RNA polymerase II, TATA box binding protein
(TBP)-associated factor, 31kDa 2
TAF9B RNA polymerase II, TATA box binding
protein-associated factor, 31kDa 1
TBP-associated factor 9L 2
Transcription initiation factor TFIID subunit 9-like 3
Transcription-associated factor TAFII31L 3
neuronal cell death-related protein 2
transcription associated factor 9B 2
transcription associated factor TAFII31L 2
transcription initiation factor IID, 31kD subunit 2
External Ids
HGNC: 173061
Entrez Gene: 516162
UniProtKB: Q9HBM63
Ensembl: ENSG000001873257
Search outside databases for aliases for TAF9B gene

Previous GC identifer: GC0XP9L0788

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TAF9B:
Initiation of transcription by RNA polymerase II requires the activities of more than 70
polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID),
which binds to the core promoter to position the polymerase properly, serves as the scaffold for
assembly of the remainder of the transcription complex, and acts as a channel for regulatory
signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily
conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal
transcription, serve as coactivators, function in promoter recognition or modify general
transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This
gene encodes a protein that is similar to one of the small subunits of TFIID, TBP-associated
factor 9, and is also a subunit of TFIID. TAF9 and TAF9b share some functions but also have
distinct roles in the transcriptional regulatory process. [provided by RefSeq]

UniProtKB/Swiss-Prot: TAF9B_HUMAN, Q9HBM6
Function: Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation
as well as repression of distinct but overlapping sets of genes. May have a role in gene
regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID)
complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA
transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA
polymerase II-mediated transcription

Gene Wiki entry for TAF9B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the TAF9B gene  

Entrez Gene cytogenetic band: Xq13.1-q21.1   Ensembl cytogenetic band:  Xq21.1   HGNC cytogenetic band: Xq13.1-q21.1

TAF9B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM077271:     (about GC identifiers)

Start:
77,271,901 bp from pter
End:
77,281,835 bp from pter
Size:
9,935 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000023.9  NT_011651.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TAF9B_HUMAN, Q9HBM6 (See protein sequence)
Recommended Name: Transcription initiation factor TFIID subunit 9B  
Size: 251 amino acids; 27622 Da
Subunit: Binds TAF5 and TAF6. Component of TFIID and the TATA-binding protein-free TAF complex
(TFTC). TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors
(TAFs). Binds N-terminal domain of TP53/p53 which is essential for transcription
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q9Y2S3

REFSEQ proteins: NP_057059.2  

ENSEMBL proteins: 
ENSP00000339917 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (TAF9b, TAF9 + TAF9b)
Human Recombinant Proteins from Abnova (TAF9B)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus IEA--
GO:0005669 transcription factor TFIID complex IEA--
About this table

Antibodies for TAF9B: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Antibodies from Abcam (TAF9b, TAF9 + TAF9b), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (TAF9B)
Novus Biologicals Antibodies for TAF9B

Assays for TAF9B: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro domains/families:
 IPR003162 TFIID-31
 IPR009072 Histone-fold


   GeneDecks  TAF9B for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q9HBM6

ProtoNet protein and cluster: Q9HBM6

1 Blocks protein family: IPB003162 Transcription factor TAFII-31

UniProtKB/Swiss-Prot: TAF9B_HUMAN, Q9HBM6
Similarity: Belongs to the TAF9 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (TAF9B)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (TAF9B)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015975

              Applied Biosystems Silencer® siRNAs for TAF9B

              Sigma-Aldrich siRNA for TAF9B  
                     Sigma-Aldrich shRNA for TAF9B  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015975
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_015975
                                 untagged cDNA clone in CMV expression vector: NM_015975 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_015975

UniProtKB/Swiss-Prot: TAF9B_HUMAN, Q9HBM6
Function: Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation
as well as repression of distinct but overlapping sets of genes. May have a role in gene
regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID)
complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA
transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA
polymerase II-mediated transcription

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003677 DNA binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Invitrogen iPath™ Online BioAtlas - Pathway for TAF9B (Maps provided by GeneGo):
 Ligand-Dependent Transcription of Retinoid-Target genes

   GeneDecks  TAF9B for the pathways selected above  
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2 Millipore Pathways for TAF9B
 Histone modification
 Transcription Ligand-Dependent Transcription of Retinoid-Target genes

   GeneDecks  TAF9B for the pathways selected above  
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for  TAF9B  (Your Favorite Gene powered by Ingenuity) 
 Estrogen Receptor Signaling
 Glucocorticoid Receptor Signaling
 Huntington's Disease Signaling

   GeneDecks  TAF9B for the pathways selected above  
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1 Kegg Pathway  (Kegg details for TAF9B):
 hsa03022 Basal transcription factors

   GeneDecks  TAF9B for the pathways selected above  
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5/10 Interacting proteins for TAF9B (ENSP000003399173 Q9HBM62) via UniProtKB, MINT, and/or STRING (see all 10 )
InteractantInteraction Details
GeneCardExternal ID(s)
DRAP1Q149192MINT-68182
TAF6ENSP000003445373STRING (score=.857)
TAF10ENSP000002994243STRING (score=.801)
TBPENSP000002303543STRING (score=.78)
TP53ENSP000002693053STRING (score=.774)
About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006350 transcription IEA--
GO:0006352 transcription initiation IEA--
GO:0006355 regulation of transcription, DNA-dependent IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TAF9B

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (TAF9B)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (TAF9B)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015975

              Sigma-Aldrich siRNA for TAF9B  
                     Sigma-Aldrich shRNA for TAF9B  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_015975  

REFSEQ mRNAs for TAF9B gene: 

NM_015975.4   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_015975  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015975
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_015975
                                 untagged cDNA clone in CMV expression vector: NM_015975 

Additional cDNA sequence: 

AF220509.1 AK312579.1 BC009566.1 BC010350.1 BC071649.1 BC146952.1 BC146960.1 CR624765.1 
CR625261.1 XM_001126120.2 

9 DOTS entries:

DT.416459  DT.100653206  DT.100787148  DT.100787153  DT.100787156  DT.100787152  DT.120715052  DT.121302638 
DT.91968505 

24/133 AceView cDNA sequences (see all 133 ):

BE017993 CK904926 N27532 BM055369 CR624765 H06850 BX324310 AA053385 
BM709654 BM800571 BI489913 CD697666 AA730103 BC071649 BI756467 AU279555 
BI824030 AA480061 Z40547 CR608622 AL559343 CR625261 BX115964 AA503204 

highest scoring ESTs for TAF9B:

AA204916 AA346718 AF220509 AL598675 BC009566 BC010350 BC071649 BE813621 BF664913 BG569325 

Unigene Cluster for TAF9B:

TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
Hs.592248  [show with all ESTs]
Unigene Representative Sequence: XM_001126120


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000341864  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TAF9B expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for TAF9B

1 / 2 / 3

11 probe-sets matching TAF9B gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
65487_at2, 3 U95-C 3 1.00 0.33 1.00 1.00 W61008 0.80 0.88 0.84 1

228483_s_at2, 3 U133-B 1 1.00 1.00 -- -- BE856250 0.40 0.67 0.55 1

226037_s_at2 U133-B 3 1.00 0.33 -- -- -- -- -- -- --

221618_s_at2, 3 U133-A 4 1.00 0.33 -- -- AF220509 0.80 1.00 0.91 1

221617_at*2, 3 U133-A NULL 0.00 0.00 -- -- AF077053 0.60 1.00 0.82 1

221616_s_at*2, 3 U133-A NULL 0.00 0.00 -- -- AF077053 0.60 1.00 0.82 1

228483_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

226037_s_at2 U133Plus2 3 1.00 0.33 -- -- -- -- -- -- --

221618_s_at2 U133Plus2 4 1.00 0.33 -- -- -- -- -- -- --

221617_at*2 U133Plus2 NULL 0.00 0.00 -- -- -- -- -- -- --

221616_s_at*2 U133Plus2 NULL 0.00 0.00 -- -- -- -- -- -- --
GeneDecks  TAF9B for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.592248
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for TAF9B gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
TAF9B1   -- TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated more 94.13(n)
95.08(a)
480965  XM_538086.2  XP_538086.2 
chimpanzee
(Pan troglodytes)
TAF9B1   -- TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated more 99.47(n)
99.6(a)
473679  XM_529052.2  XP_529052.2 
cow
(Bos taurus)
TAF9B1   -- TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated more 94.11(n)
95.98(a)
538983  XM_584087.3  XP_584087.1 
rat
(Rattus norvegicus)
Taf9b1   -- TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated more 91.8(n)
90.57(a)
171152  NM_133615.1  NP_598299.1 
mouse
(Mus musculus)
Taf9b1   -- TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated more 91.16(n)
90.36(a)
407786  NM_001001176.1  NP_001001176.1 
About this table        Species with no ortholog for TAF9B

ENSEMBL Gene Tree for TAF9B
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for TAF9B gene
LOC7281981  ENSG000002157602  TAF92  

Pseudogenes
1 related pseudogene


(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


2 NCBI SNPs in TAF9B are shown
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr X posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs26435811,2
A,C,F77282556(+) ACACCC/TTTCCC 1 -- ng313Minor allele frequency- T:0.26NA 115
--
rs563267541,2
--77272404(+) TGATAC/TGAACA 1 -- ut310--------
About this table
The following additional 1 SNP(s) have been found in Applied Biosystems data source:
(Click for Applied Biosystems TaqMan ® Genotyping Assay)


 rs16978765

HapMap Linkage Disequilibrium images for TAF9B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300754

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

9 PubMed articles for TAF9B gene:
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 51616 HGNC: 17306 AceView: TAF9L Ensembl:ENSG00000187325 euGenes: HUgn51616
ECgene: TAF9B H-InvDB: TAF9B
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for TAF9B:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for TAF9B-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


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 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for TAF9B Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant & Natural Proteins  

 Recombinant Proteins (TAF9B)
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 Recombinant Proteins
(TAF9b, TAF9 + TAF9b)
 Antibodies (TAF9b, TAF9 + TAF9b)
 Search OriGene for TAF9B
 Search Tocris compounds for TAF9B




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for TAF9B

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