TAF9B Gene
protein-coding GIFtS: 56
GCID: GC0XM077385
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TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated...(Previous names: TAF9-like RNA polymerase II, TATA box binding protein (TBP)-associated...)
(Previous symbol: TAF9L)
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Aliases
for TAF9B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TAF9B RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor,31kDa1 2 | | Neuronal Cell Death-Related Protein 72 3 | | TAF9L1 2 3 5 | | Transcription-Associated Factor TAFII31L2 3 | | DN-71 2 3 | | TBP-Associated Factor 9L2 | | TAFII31L1 2 5 | | Transcription Associated Factor TAFII31L2 | | DN71 2 | | Transcription Initiation Factor IID, 31kD Subunit2 | | TFIID-311 2 | | Transcription Initiation Factor TFIID Subunit 9B2 | | TAF9-Like RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor,31kDa1 2 | | Transcription Initiation Factor TFIID Subunit 9-Like3 |
Export aliases for TAF9B gene to outside databasesPrevious GC identifers: GC0XP9L0788 GC0XM077271 GC0XM070971 |
Summaries
for TAF9B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TAF9B:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein thatcoordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position thepolymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as achannel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarilyconserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve ascoactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complexassembly and transcription initiation. This gene encodes a protein that is similar to one of the small subunits ofTFIID, TBP-associated factor 9, and is also a subunit of TFIID. TAF9 and TAF9b share some functions but also havedistinct roles in the transcriptional regulatory process. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TAF9B_HUMAN, Q9HBM6Function: Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repressionof distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs arecomponents of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histoneacetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulationof RNA polymerase II-mediated transcription
Gene Wiki entry for TAF9B
|
Genomic Views
for TAF9B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011651.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TAF9B gene promoter:
FOXF2 Pax-2 Pax-2a Cdc5 YY1 C/EBPalpha CHOP-10 POU2F1 Pax-2b POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for TAF9B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAF9B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq13.1-q21.1 Ensembl cytogenetic band: Xq21.1 HGNC cytogenetic band: Xq13.1-q21.1TAF9B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM077385: view genomic region
(about GC identifiers)
Start:
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77,385,245 bp from pter |
End:
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77,395,203 bp from pter |
Size:
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9,959 bases |
Orientation:
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minus strand |
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Proteins
for TAF9B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TAF9B_HUMAN, Q9HBM6 (See
protein sequence)Recommended Name: Transcription initiation factor TFIID subunit 9B Size: 251 amino acids; 27622 Da
Subunit: Binds TAF5 and TAF6. Component of TFIID and the TATA-binding protein-free TAF complex (TFTC). TFIID iscomposed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Binds N-terminal domain ofp53/TP53 which is essential for transcription
Subcellular location: Nucleus (By similarity)
Secondary accessions: B2RUZ9 Q9Y2S3Explore the universe of human proteins at neXtProt for TAF9B: NX_Q9HBM6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9HBM6
TAF9B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057059.2
ENSEMBL proteins: ENSP00000339917
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TAF9B for ontologies About GeneDecksing
TAF9B Antibody Products:
Assay Products for TAF9B: |
Protein
Domains /
Families
for TAF9B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TAF9B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9HBM6ProtoNet protein and cluster: Q9HBM6 1 Blocks protein family: IPB003162 Transcription factor TAFII-31
UniProtKB/Swiss-Prot: TAF9B_HUMAN, Q9HBM6Similarity: Belongs to the TAF9 family |
Function
for TAF9B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TAF9B_HUMAN, Q9HBM6Function: Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repressionof distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs arecomponents of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histoneacetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulationof RNA polymerase II-mediated transcription
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF9B |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
TAF9B for ontologies About GeneDecksing
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Taf9b):
TAF9B for phenotypes About GeneDecksing
|
Pathways & Interactions
for TAF9B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | HIV Infection | | | 2 | Assembly of RNA Polymerase-II Initiation Complex | | | 3 | Signal transduction Activin A signaling regulation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for TAF9B
1  GeneGo (Thomson Reuters) Pathway for TAF9B
1 
Kegg Pathway (Kegg details for TAF9B):
TAF9B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAF9B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/51 Interacting proteins for TAF9B (Q9HBM62, 3 ENSP000003399174) via UniProtKB, MINT, STRING, and/or I2D (see all 51)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter |
IMP | 12837753 | | GO:0006352 | DNA-dependent transcription, initiation |
IEA | -- | | GO:0012501 | programmed cell death |
IEA | -- | | GO:0014070 | response to organic cyclic compound |
IEA | -- | | GO:0030307 | positive regulation of cell growth |
IMP | 15899866 |
TAF9B for ontologies About GeneDecksing
|
Drugs & Compounds
for TAF9B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TAF9B
Search CenterWatch for drugs/clinical trials and news about TAF9B
|
Transcripts
for TAF9B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TAF9B gene: NM_015975.4 Unigene Cluster for TAF9B: TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa Hs.592248 [show with all ESTs]Unigene Representative Sequence: NM_0159752 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000341864(uc004eda.3) ENST00000480681
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAF9B (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAF9B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TAF9B (NM_015975) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAF9B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAF9B |
Additional cDNA sequence: AF220509.1 AK312579.1 BC009566.1 BC010350.1 BC071649.1 BC146952.1 BC146960.1 13 DOTS entries: DT.416459 DT.100653206 DT.100787148 DT.100787153 DT.100787156 DT.100695458 DT.121302495 DT.100787155 DT.100800948 DT.100787152 DT.121302496 DT.121302600 DT.91744754 24/133 AceView cDNA sequences (see all 133): Z40547 AW511468 BM709654 AL559343 CD697666 AA688236 AA811522 BI489913 CR608622 BU160638 AF220509 AL525008 BM055369 BI756467 AL521603 CD243174 AA503204 BX115964 BX324310 BM561697 AU279555 AA730103 BM800571 BU156819
GeneLoc Exon Structure
|
Expression
for TAF9B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TAF9B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTGATAAG
About this image
See TAF9B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TAF9B
SOURCE GeneReport for Unigene cluster: Hs.592248
SABiosciences Custom PCR Arrays for TAF9B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAF9B
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF9B |
Orthologs
for TAF9B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TAF9B gene from 7/24 species (see all 24) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TAF96 |
Uncharacterized protein |
82(a) |
1 → many |
4(1269659-1272886) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
77(a) |
1 → many |
GL343400.1(393367-398156) |
zebrafish
(Danio rerio) |
Actinopterygii |
taf96 |
TAF9 RNA polymerase II, TATA box binding protein (... |
76(a) |
1 → many |
21(37684305-37690900) |
fruit fly
(Drosophila melanogaster) |
Insecta |
e(y)16 |
enhancer of yellow 1 |
31(a) |
1 → many |
X(17736208-17737381) |
worm
(Caenorhabditis elegans) |
Secernentea |
taf-96 |
TAF (TBP-associated transcription factor) family m... |
28(a) |
1 → many |
III(13624173-13625840) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
TAFII216 |
transcription initiation factor TFIID subunit D7 |
34(a) |
1 → many |
1(20213967-20215223) |
rice
(Oryza sativa) |
Liliopsida |
---- |
transcription initiation factor IID, putative |
30(a)14(a) |
many ↔ manymany ↔ many |
3(16793108-16798360) 7(25218515-25222059) |
ENSEMBL Gene Tree for TAF9B (if available)
TreeFam Gene Tree for TAF9B (if available) |
Paralogs
for TAF9B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TAF9B gene
- TAF92
1 SIMAP similar gene for TAF9B using alignment to 1 protein entry: TAF9B_HUMAN:TAF9
TAF9B for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for TAF9B
PGOHUM00000238928 PGOHUM00000237966
|
Genomic Variants
for TAF9B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TAF9B (77385245 - 77395203 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TAF9B
1 CNV: 0245
Locus Specific Mutation Databases (LSDB): TAF9B
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TAF9B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TAF9B for disorders About GeneDecksing
OMIM gene information: 300754
OMIM disorders: --
1  disease for TAF9B: About MalaCardsneuronitis
Export disorders for TAF9B gene to outside databases
|
Publications
for TAF9B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TAF9B gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with TAF9B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- TAF9b (formerly TAF9L) is a bona fide TAF that has unique and overlapping roles with TAF9. (PubMed id 15899866)1, 2, 3 Frontini M.... Tora L. (2005)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- In vivo functional analysis of the histone 3-like TAF9 and a TAF9-related factor, TAF9L. (PubMed id 12837753)1, 9 Chen Z. and Manley J.L. (2003)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
|
External Searches for TAF9B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TAF9B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TAF9B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TAF9B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TAF9B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TAF9B gene:
Search GeneIP for patents involving TAF9B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TAF9B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |  |  |  |  | | | | |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF9B |
|  |  |  | | | | Search ThermoFisher Antibodies for TAF9B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAF9B |
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