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Aliases for TAF9B Gene

Aliases for TAF9B Gene

  • TATA-Box Binding Protein Associated Factor 9b 2 3 5
  • TAF9-Like RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 31kDa 2 3
  • TAF9B RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 31kDa 2 3
  • Transcription-Associated Factor TAFII31L 3 4
  • Neuronal Cell Death-Related Protein 7 3 4
  • TAF9L 3 4
  • DN-7 3 4
  • Transcription Initiation Factor TFIID Subunit 9-Like 4
  • Transcription Initiation Factor IID, 31kD Subunit 3
  • Transcription Initiation Factor TFIID Subunit 9B 3
  • TBP-Associated Factor 9L 3
  • TAFII31L 3
  • TFIID-31 3
  • DN7 3

External Ids for TAF9B Gene

Previous HGNC Symbols for TAF9B Gene

  • TAF9L

Previous GeneCards Identifiers for TAF9B Gene

  • GC0XP9L0788
  • GC0XM077271
  • GC0XM077385
  • GC0XM070971

Summaries for TAF9B Gene

Entrez Gene Summary for TAF9B Gene

  • Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is similar to one of the small subunits of TFIID, TBP-associated factor 9, and is also a subunit of TFIID. TAF9 and TAF9b share some functions but also have distinct roles in the transcriptional regulatory process. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAF9B Gene

TAF9B (TATA-Box Binding Protein Associated Factor 9b) is a Protein Coding gene. Diseases associated with TAF9B include Usher Syndrome, Type 1B. Among its related pathways are Formation of HIV elongation complex in the absence of HIV Tat and HIV Life Cycle. GO annotations related to this gene include protein heterodimerization activity and transcription corepressor activity. An important paralog of this gene is TAF9.

UniProtKB/Swiss-Prot for TAF9B Gene

  • Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription.

Gene Wiki entry for TAF9B Gene

Additional gene information for TAF9B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF9B Gene

Genomics for TAF9B Gene

Regulatory Elements for TAF9B Gene

Enhancers for TAF9B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH078102 1.1 ENCODE 26.1 +34.7 34652 4 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 FOS TAF9B CYSLTR1 FGF16 GC0XP078105 GC0XP078104 GC0XM078132 GC0XM078131 GC0XM078130
GH0XH078064 1.1 Ensembl ENCODE 19.3 +74.1 74078 2 TBL1XR1 INSM2 BMI1 GLI4 BATF ATF7 FOS ETV6 RUNX3 CREM TAF9B PGK1 GC0XM078066
GH0XH077784 1.2 Ensembl ENCODE 12.2 +352.9 352865 4 PKNOX1 FOXA2 ATF1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 GLIS2 TAF9B ATRX GC0XP077838
GH0XH078325 0.6 ENCODE 22.3 -188.7 -188724 5 NR2F1 IKZF1 JUNB EBF1 RUNX3 BATF TAF9B CYSLTR1 FGF16 HMGN1P34
GH0XH078321 0.8 Ensembl ENCODE 15.6 -183.2 -183193 2 IKZF1 ELF1 ETV6 DPF2 RUNX3 SPI1 TAF9B CYSLTR1 GC0XP078309
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAF9B on UCSC Golden Path with GeneCards custom track

Promoters for TAF9B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247343 305 1599 ATF1 SIN3A ZNF2 YY1 GLIS2 ELK1 PAF1 SP3 SP5 YY2

Genomic Location for TAF9B Gene

Chromosome:
X
Start:
78,129,748 bp from pter
End:
78,139,706 bp from pter
Size:
9,959 bases
Orientation:
Minus strand

Genomic View for TAF9B Gene

Genes around TAF9B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF9B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF9B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF9B Gene

Proteins for TAF9B Gene

  • Protein details for TAF9B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HBM6-TAF9B_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 9B
    Protein Accession:
    Q9HBM6
    Secondary Accessions:
    • B2RUZ9
    • Q9Y2S3

    Protein attributes for TAF9B Gene

    Size:
    251 amino acids
    Molecular mass:
    27622 Da
    Quaternary structure:
    • Binds TAF5 and TAF6. Component of TFIID and the TATA-binding protein-free TAF complex (TFTC). TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Binds N-terminal domain of p53/TP53 which is essential for transcription.

neXtProt entry for TAF9B Gene

Post-translational modifications for TAF9B Gene

  • Ubiquitination at Lys24
  • Modification sites at PhosphoSitePlus

Other Protein References for TAF9B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAF9B Gene

Domains & Families for TAF9B Gene

Gene Families for TAF9B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TAF9B Gene

Suggested Antigen Peptide Sequences for TAF9B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9HBM6

UniProtKB/Swiss-Prot:

TAF9B_HUMAN :
  • Belongs to the TAF9 family.
Family:
  • Belongs to the TAF9 family.
genes like me logo Genes that share domains with TAF9B: view

Function for TAF9B Gene

Molecular function for TAF9B Gene

UniProtKB/Swiss-Prot Function:
Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription.

Gene Ontology (GO) - Molecular Function for TAF9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001075 contributes_to transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly IBA --
GO:0003714 transcription corepressor activity IC 12837753
GO:0004402 contributes_to histone acetyltransferase activity IBA --
GO:0005515 protein binding IPI 15899866
GO:0008134 transcription factor binding IBA --
genes like me logo Genes that share ontologies with TAF9B: view

Phenotypes for TAF9B Gene

genes like me logo Genes that share phenotypes with TAF9B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TAF9B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAF9B Gene

Localization for TAF9B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF9B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAF9B gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TAF9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000124 SAGA complex IBA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex IDA 15899866
GO:0033276 transcription factor TFTC complex IDA 15899866
genes like me logo Genes that share ontologies with TAF9B: view

Pathways & Interactions for TAF9B Gene

genes like me logo Genes that share pathways with TAF9B: view

Gene Ontology (GO) - Biological Process for TAF9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 12837753
GO:0006351 transcription, DNA-templated IEA --
GO:0006352 DNA-templated transcription, initiation IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with TAF9B: view

No data available for SIGNOR curated interactions for TAF9B Gene

Drugs & Compounds for TAF9B Gene

No Compound Related Data Available

Transcripts for TAF9B Gene

mRNA/cDNA for TAF9B Gene

Unigene Clusters for TAF9B Gene

TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TAF9B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TAF9B Gene

No ASD Table

Relevant External Links for TAF9B Gene

GeneLoc Exon Structure for
TAF9B
ECgene alternative splicing isoforms for
TAF9B

Expression for TAF9B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAF9B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TAF9B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (48.2), Placenta (9.8), and Fetal ovary (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TAF9B Gene



Protein tissue co-expression partners for TAF9B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TAF9B Gene:

TAF9B

SOURCE GeneReport for Unigene cluster for TAF9B Gene:

Hs.592248

Evidence on tissue expression from TISSUES for TAF9B Gene

  • Nervous system(3.3)
genes like me logo Genes that share expression patterns with TAF9B: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAF9B Gene

Orthologs for TAF9B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAF9B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF9B 33 34
  • 99.47 (n)
dog
(Canis familiaris)
Mammalia TAF9B 33 34
  • 94.38 (n)
cow
(Bos Taurus)
Mammalia TAF9B 33 34
  • 93.89 (n)
rat
(Rattus norvegicus)
Mammalia Taf9b 33
  • 91.8 (n)
mouse
(Mus musculus)
Mammalia Taf9b 33 16 34
  • 91.3 (n)
oppossum
(Monodelphis domestica)
Mammalia TAF9B 34
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 58 (a)
OneToMany
chicken
(Gallus gallus)
Aves TAF9 34
  • 80 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 76 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii taf9 34
  • 75 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta e(y)1 34
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea taf-9 34
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF9 34
  • 29 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
OneToMany
Species where no ortholog for TAF9B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TAF9B Gene

ENSEMBL:
Gene Tree for TAF9B (if available)
TreeFam:
Gene Tree for TAF9B (if available)

Paralogs for TAF9B Gene

Paralogs for TAF9B Gene

(1) SIMAP similar genes for TAF9B Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TAF9B Gene

genes like me logo Genes that share paralogs with TAF9B: view

Variants for TAF9B Gene

Sequence variations from dbSNP and Humsavar for TAF9B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs875989809 Uncertain significance 78,136,913(-) TACTA(AA/TAGGT)AAGTG splice-donor-variant
rs1000285906 -- 78,131,872(+) AATTC(A/T)AATAC intron-variant
rs1000672975 -- 78,138,400(+) TCCCC(C/T)AGCTT intron-variant
rs1001377763 -- 78,140,716(+) TCCAT(C/T)CAGTG upstream-variant-2KB
rs1001852250 -- 78,139,205(+) CAGCT(G/T)GTTGT intron-variant

Variation tolerance for TAF9B Gene

Residual Variation Intolerance Score: 42.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAF9B Gene

Human Gene Mutation Database (HGMD)
TAF9B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAF9B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TAF9B Gene

Disorders for TAF9B Gene

MalaCards: The human disease database

(1) MalaCards diseases for TAF9B Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
usher syndrome, type 1b
  • usher syndrome type 1
- elite association - COSMIC cancer census association via MalaCards
Search TAF9B in MalaCards View complete list of genes associated with diseases

Relevant External Links for TAF9B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAF9B
genes like me logo Genes that share disorders with TAF9B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAF9B Gene

Publications for TAF9B Gene

  1. TAF9b (formerly TAF9L) is a bona fide TAF that has unique and overlapping roles with TAF9. (PMID: 15899866) Frontini M … Tora L (Molecular and cellular biology 2005) 2 3 4 60
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. In vivo functional analysis of the histone 3-like TAF9 and a TAF9-related factor, TAF9L. (PMID: 12837753) Chen Z … Manley JL (The Journal of biological chemistry 2003) 3 22 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for TAF9B Gene

Sources for TAF9B Gene

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