TAF9B Gene
protein-coding GIFtS : 54
GC0XM077271
TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa (Previous names: TAF9-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31 kD, TAF9-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbol: TAF9L )
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Aliases & Descriptions for TAF9B
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases DN-7 1 , 2 , 3 DN7 1 , 2 OTTHUMP00000023594 2 TAF9L 2 , 3 , 5 TAFII31L 1 , 2 , 5 TFIID-31 1 , 2
Descriptions Neuronal cell death-related protein 7 3 TAF9-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31 kD 1 , 2 TAF9-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 1 , 2 TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2 TAF9B RNA polymerase II, TATA box binding protein-associated factor, 31kDa 1 TBP-associated factor 9L 2 Transcription initiation factor TFIID subunit 9-like 3 Transcription-associated factor TAFII31L 3 neuronal cell death-related protein 2 transcription associated factor 9B 2 transcription associated factor TAFII31L 2 transcription initiation factor IID, 31kD subunit 2
Search outside databases for aliases for TAF9B genePrevious GC identifer: GC0XP9L0788
Summaries for TAF9B (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for TAF9B : Initiation of transcription by RNA polymerase II requires the activities of more than 70polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID),which binds to the core promoter to position the polymerase properly, serves as the scaffold forassembly of the remainder of the transcription complex, and acts as a channel for regulatorysignals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarilyconserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basaltranscription, serve as coactivators, function in promoter recognition or modify generaltranscription factors (GTFs) to facilitate complex assembly and transcription initiation. Thisgene encodes a protein that is similar to one of the small subunits of TFIID, TBP-associatedfactor 9, and is also a subunit of TFIID. TAF9 and TAF9b share some functions but also havedistinct roles in the transcriptional regulatory process. [provided by RefSeq] UniProtKB/Swiss-Prot: TAF9B_HUMAN, Q9HBM6 Function : Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activationas well as repression of distinct but overlapping sets of genes. May have a role in generegulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID)complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGAtranscription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNApolymerase II-mediated transcription
Gene Wiki entry for TAF9B
Genomic Location for TAF9B
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the TAF9B gene Entrez Gene cytogenetic band: Xq13.1-q21.1 Ensembl cytogenetic band: Xq21.1 HGNC cytogenetic band: Xq13.1-q21.1 TAF9B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XM077271:
(about GC identifiers )
Start:
77,271,901 bp from pter
End:
77,281,835 bp from pter
Size:
9,935 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000023.9 NT_011651.16 Proteins for TAF9B
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: TAF9B_HUMAN, Q9HBM6 (See
protein sequence )Recommended Name: Transcription initiation factor TFIID subunit 9B Size : 251 amino acids; 27622 Da
Subunit : Binds TAF5 and TAF6. Component of TFIID and the TATA-binding protein-free TAF complex(TFTC). TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors(TAFs). Binds N-terminal domain of TP53/p53 which is essential for transcription
Subcellular location : Nucleus (By similarity)
Secondary accessions : Q9Y2S3
REFSEQ proteins: NP_057059.2 ENSEMBL proteins: ENSP00000339917 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA -- GO:0005669 transcription factor TFIID complex
IEA --
About this table Antibodies for TAF9B: Assays for TAF9B:
Protein
Domains/ Families for TAF9B(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q9HBM6 ProtoNet protein and cluster: Q9HBM6
1 Blocks protein family : IPB003162 Transcription factor TAFII-31 UniProtKB/Swiss-Prot: TAF9B_HUMAN, Q9HBM6 Similarity : Belongs to the TAF9 family
Gene Function for TAF9B
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015975 Applied Biosystems Silencer ® siRNAs for TAF9B Sigma-Aldrich siRNA for TAF9B Sigma-Aldrich shRNA for TAF9B Explore Sigma-Aldrich super-pooled esiRNAs               OriGene GFP tagged cDNA clone in CMV expression vector: NM_015975                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015975                                  untagged cDNA clone in CMV expression vector: NM_015975  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_015975 UniProtKB/Swiss-Prot: TAF9B_HUMAN, Q9HBM6 Function : Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activationas well as repression of distinct but overlapping sets of genes. May have a role in generegulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID)complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGAtranscription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNApolymerase II-mediated transcription
1 Gene Ontology (GO) molecular function term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0003677 DNA binding
IEA --
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Pathways & Interactions for TAF9B
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for TAF9B (Your Favorite Gene powered by Ingenuity) 5/10 Interacting proteins for TAF9B (ENSP00000339917 3 Q9HBM6 2 ) via UniProtKB, MINT, and/or STRING (see all 10
)About this table 3 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006350 transcription
IEA -- GO:0006352 transcription initiation
IEA -- GO:0006355 regulation of transcription, DNA-dependent
IEA --
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Drugs & Compounds for TAF9B (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Transcripts for TAF9B(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015975 Sigma-Aldrich siRNA for TAF9B Sigma-Aldrich shRNA for TAF9B Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_015975
REFSEQ mRNAs for TAF9B gene: NM_015975.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_015975
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015975                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_015975                                  untagged cDNA clone in CMV expression vector: NM_015975  
Additional cDNA sequence: AF220509.1 AK312579.1 BC009566.1 BC010350.1 BC071649.1 BC146952.1 BC146960.1 CR624765.1 CR625261.1 XM_001126120.2
9 DOTS entries : DT.416459 DT.100653206 DT.100787148 DT.100787153 DT.100787156 DT.100787152 DT.120715052 DT.121302638 DT.91968505
24/133 AceView cDNA sequences (see all 133
):BE017993 CK904926 N27532 BM055369 CR624765 H06850 BX324310 AA053385 BM709654 BM800571 BI489913 CD697666 AA730103 BC071649 BI756467 AU279555 BI824030 AA480061 Z40547 CR608622 AL559343 CR625261 BX115964 AA503204
highest scoring ESTs for TAF9B :AA204916 AA346718 AF220509 AL598675 BC009566 BC010350 BC071649 BE813621 BF664913 BG569325
Unigene Cluster for TAF9B: TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa Hs.592248 [show with all ESTs ] Unigene Representative Sequence: XM_001126120 GeneLoc Exon Structure 1 Ensembl transcript including schematic representation : ENST00000341864
Expression for TAF9B
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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TAF9B expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for TAF9B 1 / 2 / 3
11 probe-sets matching TAF9B gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.592248
Orthologs for TAF9B
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for TAF9B gene from 5/7 species (see all 7
)
Organism
Gene
Locus
Description
Human Similarity
NCBI accessions
dog (Canis familiaris)
TAF9B1
--
TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated more
94.13(n) 95.08(a)
480965 XM_538086.2 XP_538086.2
chimpanzee (Pan troglodytes)
TAF9B1
--
TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated more
99.47(n) 99.6(a)
473679 XM_529052.2 XP_529052.2
cow (Bos taurus)
TAF9B1
--
TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated more
94.11(n) 95.98(a)
538983 XM_584087.3 XP_584087.1
rat (Rattus norvegicus)
Taf9b1
--
TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated more
91.8(n) 90.57(a)
171152 NM_133615.1 NP_598299.1
mouse (Mus musculus)
Taf9b1
--
TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated more
91.16(n) 90.36(a)
407786 NM_001001176.1 NP_001001176.1
About this table Species with no ortholog for TAF9B ENSEMBL Gene Tree for TAF9B Paralogs for TAF9B (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for TAF9B gene LOC728198 1 ENSG00000215760 2 TAF9 2 Pseudogenes 1 related pseudogene
SNPs/Variants for TAF9B (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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The following additional 1 SNP(s) have been
found in Applied Biosystems data source:(Click
for
Applied Biosystems TaqMan ® Genotyping Assay ) HapMap Linkage Disequilibrium images for TAF9B (up to first 250kb)
Disorders & Mutations for TAF9B
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 300754
Medical News for TAF9B (Possibly Related Articles in
Doctor's Guide )
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--
Publications for TAF9B (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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9 PubMed articles for TAF9B gene :
Search for TAF9B
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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AND OR
Aliases
TAF9B (Gene Symbol) DN-7 DN7 OTTHUMP00000023594 TAF9L TAFII31L TFIID-31 Neuronal cell death-related protein 7 TAF9-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31 kD TAF9-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa TAF9B RNA polymerase II, TATA box binding protein-associated factor, 31kDa TBP-associated factor 9L Transcription initiation factor TFIID subunit 9-like Transcription-associated factor TAFII31L neuronal cell death-related protein transcription associated factor 9B transcription associated factor TAFII31L transcription initiation factor IID, 31kD subunit
Free Text
Query String
PubMed
OMIM
NCBI Bookshelf
(Note: In FireFox, select the above section and copy using Ctrl-C)
Genome Databases showing TAF9B
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing TAF9B
(According to HUGE )
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--
Specialized Databases showing TAF9B (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for TAF9B (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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