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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAF9 Gene

protein-coding   GIFtS: 67
GCID: GC05M068646

TAF9 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated...

(Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase...)
(Previous symbol: TAF2G)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TAF9 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated
Factor, 32kDa1 2
     MGC:50672
TAF2G1 2 3 5     TAFIID322
TAFII322 3 5     Transcription Initiation Factor TFIID 31 KD Subunit2
Transcription Initiation Factor TFIID 31 KDa Subunit2 3     Transcription Initiation Factor TFIID Subunit 92
Transcription Initiation Factor TFIID 32 KDa Subunit2 3     AK/ATPase3
STAF31/322 3     AK63
TAFII-312 3     CINAP3
TAFII-322 3     Adrenal Gland Protein AD-0043
TAFII312 3     Coilin-Interacting Nuclear ATPase Protein3
RNA Polymerase II TBP-Associated Factor Subunit G2 3     Dual Activity Adenylate Kinase/ATPase3
EC 2.7.4.33 8     hCINAP3
TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, G,
32kD1
     

External Ids:    HGNC: 115421   Entrez Gene: 68802   Ensembl: ENSG000000852317   OMIM: 6008225   UniProtKB: Q9Y3D83   
UniProtKB: Q165943   

Export aliases for TAF9 gene to outside databases

Previous GC identifers: GC05M068800 GC05M070213 GC05M068617 GC05M068663 GC05M068683 GC05M065603


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TAF9 Gene:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein
that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to
position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription
complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a
group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal
transcription, serve as coactivators, function in promoter recognition or modify general transcription factors
(GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits
of TFIID that binds to the basal transcription factor GTF2B as well as to several transcriptional activators such
as p53 and VP16. In human, TAF9 and AK6 (GeneID: 102157402) are two distinct genes that share 5' exons. A similar
but distinct gene (TAF9L) has been found on the X chromosome and a pseudogene has been identified on chromosome
19. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Sep 2013)

GeneCards Summary for TAF9 Gene: 
TAF9 (TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa) is a protein-coding gene. Diseases associated with TAF9 include bare lymphocyte syndrome, and spinal muscular atrophy, and among its related super-pathways are RNA Polymerase II Pre-transcription Events and Assembly of RNA Polymerase-II Initiation Complex. GO annotations related to this gene include protein heterodimerization activity and transcription regulatory region DNA binding. An important paralog of this gene is TAF9B.

UniProtKB/Swiss-Prot: TAF9_HUMAN, Q16594
Function: Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as
repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with
apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex
(TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are
essential for the regulation of RNA polymerase II-mediated transcription

Gene Wiki entry for TAF9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAF9 gene promoter:
         ATF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAF9 promoter sequence
   Search SABiosciences Chromatin IP Primers for TAF9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAF9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.2   Ensembl cytogenetic band:  5q13.2   HGNC cytogenetic band: 5q13.2

TAF9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAF9 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M068646:  view genomic region     (about GC identifiers)

Start:
68,646,811 bp from pter      End:
68,665,840 bp from pter
Size:
19,030 bases      Orientation:
minus strand

1 alternative location:
Chr5-,NW_003315917.2 134,919-153,209     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KAD6_HUMAN, Q9Y3D8 (See protein sequence)
Recommended Name: Adenylate kinase isoenzyme 6  
Size: 172 amino acids; 20061 Da
Subunit: Monomer and homodimer (By similarity). Interacts with COIL (via C-terminus)
Subcellular location: Nucleus, nucleoplasm. Nucleus, Cajal body. Note=Displays widespread diffuse nucleoplasmic
distribution but not detected in nucleoli. Detected in Cajal bodies but not in all cells
5 PDB 3D structures from and Proteopedia for TAF9:
1RKB (3D)        3IIJ (3D)        3IIK (3D)        3IIL (3D)        3IIM (3D)    
Secondary accessions: A8MSZ6 Q5F2S9
Alternative splicing: 3 isoforms:  Q9Y3D8-1   Q16594-1   Q9Y3D8-2   

UniProtKB/Swiss-Prot: TAF9_HUMAN, Q16594 (See protein sequence)

Recommended Name: Transcription initiation factor TFIID subunit 9  
Size: 264 amino acids; 28974 Da
Subunit: Component of TFIID, the TATA-binding protein-free TAF complex (TFTC), the PCAF complex and the STAGA
transcription coactivator-HAT complex. The PCAF complex consists at least of TADA2L/ADA2, SUPT3H/SPT3,
TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP. The STAGA
transcription coactivator-HAT complex consists at least of SUPT3H, GCN5L2, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L,
TAF10, TAF12, TRRAP and TAF9. Binds N-terminal domain of p53/TP53 which is essential for transcription. Component
of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5,
as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA,
MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10.
Binds TFIIB and the Herpes simplex virus activator VP16. Forms a heterodimer with TAF6/TAFII80 in a complex with
the TAF4B/TAFII105-TAF12/TAFII20 heterodimer. Also interacts with TAF5. Binds directly DNA. Increased DNA binding
when complexed with TAF6/TAFII80
Subcellular location: Nucleus
Secondary accessions: D3DWA3 Q5U0D1 Q9BTS1
Alternative splicing: 3 isoforms:  Q16594-1   Q9Y3D8-1   Q9Y3D8-2   

Explore the universe of human proteins at neXtProt for TAF9: NX_Q16594

Explore proteomics data for TAF9 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16594

  • 4/5 DME Specific Peptides for TAF9 (Q9Y3D8) (see all 5)
     VDYHGCD  TGTPGVGK  NVGDLARE  CPILDEDRV 

    TAF9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TAF9 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001015892.1  NP_003178.1  

    ENSEMBL proteins: 
     ENSP00000370201   ENSP00000370197   ENSP00000420947   ENSP00000421873   ENSP00000217893  
     ENSP00000425944   ENSP00000427343   ENSP00000426283   ENSP00000425798   ENSP00000427617  
     ENSP00000370193  
    Reactome Protein details: Q16594
    Human Recombinant Protein Products for TAF9: 
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    ProSpec Recombinant Protein for TAF9
    Cloud-Clone Corp. Proteins for TAF9 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000125PCAF complex IDA9674425
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005669transcription factor TFIID complex IDA14580349
    GO:0015030Cajal body ----

    TAF9 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR003162 TFIID-31
     IPR027417 P-loop_NTPase
     IPR009072 Histone-fold

    Graphical View of Domain Structure for InterPro Entry Q9Y3D8
    Graphical View of Domain Structure for InterPro Entry Q16594

    ProtoNet protein and cluster: Q9Y3D8

    UniProtKB/Swiss-Prot: KAD6_HUMAN, Q9Y3D8
    Similarity: Belongs to the adenylate kinase family. AK6 subfamily

    UniProtKB/Swiss-Prot: TAF9_HUMAN, Q16594
    Similarity: Belongs to the TAF9 family


    TAF9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KAD6_HUMAN, Q9Y3D8
    Function: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the
    terminal phosphate group between nucleoside triphosphates and monophosphates. AMP and dAMP are the preferred
    substrates, but CMP and dCMP are also good substrates. IMP is phosphorylated to a much lesser extent. All
    nucleoside triphosphates ATP, GTP, UTP, CTP, dATP, dCTP, dGTP, and TTP are accepted as phosphate donors. CTP is
    the best phosphate donor, followed by UTP, ATP, GTP and dCTP. May have a role in nuclear energy homeostasis. Has
    also ATPase activity. May be involved in regulation of Cajal body (CB) formation
    Catalytic activity: ATP + AMP = 2 ADP
    Biophysicochemical properties: Kinetic parameters: KM=192 uM for AMP; KM=45 uM for ATP (for adenylate kinase
    activity); KM=332 uM for ATP (for ATPase activity); Vmax=1.27 umol/min/mg enzyme for ATPase activity; Vmax=982
    nmol/min/mg enzyme for the forward adenylate kinase reaction; Vmax=955 nmol/min/mg enzyme for the reverse
    adenylate kinase reaction; Note=kcat is 6.3 sec(-1) for adenylate kinase activity. kcat is 4.8 sec(-1) for ATPase
    activity;

         UniProtKB/Swiss-Prot: TAF9_HUMAN, Q16594
    Function: Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as
    repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with
    apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex
    (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are
    essential for the regulation of RNA polymerase II-mediated transcription
    Induction: 6 to 8-fold by apoptotic signals

         Enzyme Number (IUBMB): EC 2.7.4.31 2

         Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IPI11278372
    GO:0003677DNA binding IDA15601843
    GO:0003713transcription coactivator activity IMP11278372
    GO:0004017adenylate kinase activity ----
    GO:0004402contributes to histone acetyltransferase activity IDA11564863
         
    TAF9 for ontologies           About GeneDecksing


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    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate TAF9:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TAF9 About   (see all 16)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    RNA Polymerase II Pre-transcription Events0.72
    RNA Polymerase II Transcription Pre-Initiation And Promoter Opening0.67
    Transcription of the HIV genome0.70
    HIV Transcription Initiation0.67
    RNA Polymerase II Transcription Initiation And Promoter Clearance0.67
    RNA Polymerase II Transcription Initiation0.67
    RNA Polymerase II Promoter Escape0.67
    Eukaryotic Transcription Initiation0.60
    2Assembly of RNA Polymerase-II Initiation Complex
    Assembly of RNA Polymerase-II Initiation Complex0.91
    Basal transcription factors0.50
    Transcription of mRNA0.91
    Crosstalk Between CARM1 and ESRs0.39
    Protein Acetylation and Deacetylation0.51
    3HIV Life Cycle
    HIV Life Cycle0.92
    HIV Infection0.61
    Late Phase of HIV Life Cycle0.92
    4Transcription
    Transcription0.69
    RNA Polymerase II Transcription0.69
    5Apoptotic Pathways in Synovial Fibroblasts
    Nuclear Receptor Activation by Vitamin-A0.57

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for TAF9
        Histone modification
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    ATP/ITP metabolism

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TAF9 (see all 7)
        Nuclear Receptor Activation by Vitamin-A
    Protein Acetylation and Deacetylation
    Assembly of RNA Polymerase-II Initiation Complex
    Glucocorticoid Receptor Signaling
    Estrogen Pathway

    2 GeneGo (Thomson Reuters) Pathways for TAF9
        ATP/ITP metabolism
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    4 BioSystems Pathways for TAF9
        Eukaryotic Transcription Initiation
    Direct p53 effectors
    C-MYC pathway
    Validated targets of C-MYC transcriptional activation

    5/15        Reactome Pathways for TAF9 (see all 15)
        RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
    Late Phase of HIV Life Cycle
    RNA Polymerase II Transcription
    Transcription
    RNA Polymerase II Transcription Initiation And Promoter Clearance


    2         Kegg Pathways  (Kegg details for TAF9):
        Ribosome biogenesis in eukaryotes
    Basal transcription factors


    TAF9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TAF9

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/596 Interacting proteins for TAF9 (Q165941, 2, 3 ENSP000002178934 Q9Y3D81, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 596)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    COILP384321, 2EBI-2896123,EBI-945751 MINT-2863455
    TAF6LQ9Y6J91, 2EBI-712521,EBI-743984 MINT-2868626
    KPNA1P522942MINT-2860217 MINT-7945693
    ABCF1Q8NE712MINT-7945693
    ABCF3Q9NUQ82MINT-7945693
    About this table

    Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006352DNA-dependent transcription, initiation ----
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--
    GO:0006974response to DNA damage stimulus IC11278372

    TAF9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TAF9

    Search CenterWatch for drugs/clinical trials and news about TAF9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TAF9 gene (2 alternative transcripts): 
    NM_001015892.1  NM_003187.4  

    Unigene Cluster for TAF9:

    TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
    Hs.653163  [show with all ESTs]
    Unigene Representative Sequence: BC033320
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380822(uc003jwa.3) ENST00000502819 ENST00000380818(uc003jwb.3)
    ENST00000512561 ENST00000506736(uc003jwc.1) ENST00000217893(uc003jwe.1)
    ENST00000503245 ENST00000509462 ENST00000504109 ENST00000512152 ENST00000508954
    ENST00000328663(uc003jwf.1)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AF110777.1 AF151895.1 AJ878880.1 AJ878881.1 BC003400.1 BC007349.2 BC007426.2 BC033320.1 
    BT019652.1 U21858.1 U25112.1 U30504.1 

    24/28 DOTS entries (see all 28):

    DT.100819169  DT.100801079  DT.452110  DT.120842325  DT.95258926  DT.120842183  DT.443071  DT.70103909 
    DT.422686  DT.120842396  DT.40307992  DT.419165  DT.121504121  DT.100703220  DT.100819170  DT.120842191 
    DT.97862317  DT.100685961  DT.100819171  DT.65286751  DT.95192818  DT.95193472  DT.120842176  DT.120842177 

    24/450 AceView cDNA sequences (see all 450):

    T08172 AA321648 AA186668 BI913284 BG942858 BM807509 BI829299 CB112296 
    BQ272160 AA743298 BQ015047 AA807382 AU098495 AA877372 U30504 BM831200 
    BC007349 BQ772517 BM994191 BC007426 CN478625 CB157872 BE467269 BU608283 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for TAF9 (see all 10)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8 ^ 9a · 9b ^ 10
    SP1:                          -     -     -     -     -     -     -           -     -     -     -     -     -     -                 -         
    SP2:        -     -     -     -     -     -     -     -     -     -                                                                           
    SP3:                          -     -     -     -     -     -     -                                                                           
    SP4:                                -     -     -     -     -     -                                                                           
    SP5:                                            -     -     -     -                                                                           


    ECgene alternative splicing isoforms for TAF9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TAF9 expression in normal human tissues (normalized intensities)      TAF9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGATGTTT
    TAF9 Expression
    About this image


    TAF9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/28 selected tissues (see all 28) fully expand
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             testis ; cells in seminiferus ducts   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   

    See TAF9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TAF9

    SOURCE GeneReport for Unigene cluster: Hs.653163
        SABiosciences Custom PCR Arrays for TAF9
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TAF9 gene from 10/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Taf91 , 5 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated more1, 5 91.09(n)1
    96.18(a)1
      13 (53.23 cM)5
    1081431  NM_001015889.21  NP_001015889.11 
     1006513435 
    chicken
    (Gallus gallus)
    Aves TAF91 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated more 73.86(n)
    86.27(a)
      422152  XM_420153.3  XP_420153.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    84(a)
    1 → many
    GL343400.1(391936-398343)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480119002   -- 74.15(n)    48011900 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb16h032 Transcribed sequence with moderate similarity to protein more 74.12(n)    BM141601.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta e(y)11 , 3 transcription initiation from Pol II
    promoter more3
    enhancer of yellow 11
    56(a)3
    53.09(n)1
    57.78(a)1
      1 16E13
    327621  NM_078667.31  NP_523391.31 
    worm
    (Caenorhabditis elegans)
    Secernentea taf-96
    Protein TAF-9
    30(a)
    1 → many
    III(13624274-13625941)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes FAP7(YDL166C)4
    TAF91
    Essential NTPase required for small ribosome subunit more4
    Taf9p1
    44.96(n)1
    34.11(a)1
      4(164042-163449)4
    8552761  NP_013963.11  8513884 
     NP_010115.14 
    soybean
    (Glycine max)
    eudicotyledons 467666932   -- 70.65(n)  
    barley
    (Hordeum vulgare)
    Liliopsida BI957056.12   -- 72.44(n)    BI957056.1 


    ENSEMBL Gene Tree for TAF9 (if available)
    TreeFam Gene Tree for TAF9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TAF9 gene
    TAF9B2  
    1 SIMAP similar gene for TAF9 using alignment to 8 protein entries:     KAD6_HUMAN (see all proteins):
    TAF9B

    TAF9 for paralogs           About GeneDecksing


    5/11 Pseudogenes.org Pseudogenes for TAF9 (see all 11)
    PGOHUM00000239409 PGOHUM00000251003 PGOHUM00000239738 PGOHUM00000234652 PGOHUM00000234653


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/329 SNPs in TAF9 are shown (see all 329)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs345258961,2
    C--65608284(+) GCCCAG/-TACGA 2 -- int11Minor allele frequency- -:0.00CSA 2
    rs1460616821,2
    C--68647084(+) CTCCT-/GC    
       CTCAA
    GCGAT
    2 -- ds50010--------
    rs610135751,2
    C--68647086(+) CCTGC-/CT    
       CAAGC
    GATTC
    2 -- ds50010--------
    rs563424531,2
    C--68647359(+) GCATAA/GAACCT 2 -- ds50010--------
    rs1122142341,2
    F--68647380(+) ATATAG/AGAAAC 2 -- ds50012Minor allele frequency- A:0.50CSA 4
    rs737725411,2
    C--68647579(+) TTTAAG/AAGATC 2 -- ut311Minor allele frequency- A:0.50WA 2
    rs1924994851,2
    --68647610(+) TAAACC/TTAAAA 2 -- ut310--------
    rs1424222311,2
    --68647727(+) TTTAGC/GTTTCT 2 -- ut310--------
    rs1477919131,2
    C--68647728(+) TTAGCA/TTTCTC 2 -- ut310--------
    rs1833789221,2
    C--68647745(+) AAAAAA/GAAACA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for TAF9 (68646811 - 68665840 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TAF9:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv881767CNV Loss21882294
    nsv881768CNV Loss21882294
    nsv821643CNV Loss15273396
    nsv428117CNV Gain+Loss18775914

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600822    OMIM disorders: --

    6 diseases for TAF9:    About MalaCards
    bare lymphocyte syndrome    spinal muscular atrophy    muscular atrophy    retinal degeneration
    retinitis    herpes simplex

    1 disease from the University of Copenhagen DISEASES database for TAF9:
    Spinal muscular atrophy

    TAF9 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TAF9
    Human Genome Epidemiology (HuGE) Navigator: TAF9 (1 document)

    Export disorders for TAF9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TAF9 gene, integrated from 9 sources (see all 91):
    (articles sorted by number of sources associating them with TAF9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of hCINAP, a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus. (PubMed id 16079131)1, 2, 3, 9 Santama N....Lamond A.I. (2005)
    2. Evolutionary conservation of human TATA-binding-polypeptide- associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors. (PubMed id 7667268)1, 2, 9 Hisatake K.... Roeder R.G. (1995)
    3. Core promoter binding by histone-like TAF complexes. (PubMed id 15601843)1, 2 Shao H.... Dikstein R. (2005)
    4. TAF9b (formerly TAF9L) is a bona fide TAF that has unique and overlapping roles with TAF9. (PubMed id 15899866)1, 2 Frontini M.... Tora L. (2005)
    5. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PubMed id 15960975)1, 2 Dou Y.... Roeder R.G. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage- binding factors in vivo. (PubMed id 11564863)1, 2 Martinez E.... Roeder R.G. (2001)
    8. Mapping and mutational analysis of the human TAF2G gene encoding a p53 cofactor. (PubMed id 10191103)1, 3 Evans S.C....Lozano G. (1999)
    9. Histone-like TAFs within the PCAF histone acetylase complex. (PubMed id 9674425)1, 2 Ogryzko V.V.... Nakatani Y. (1998)
    10. The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily. (PubMed id 9885574)1, 2 Vassilev A....Nakatani Y. (1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6880 HGNC: 11542 AceView: TAF9 Ensembl:ENSG00000085231 euGenes: HUgn6880
    ECgene: TAF9 Kegg: 6880 H-InvDB: TAF9

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TAF9 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TAF9 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/taf9/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TAF9 gene:
    Search GeneIP for patents involving TAF9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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