Aliases for TAF9 Gene
- TAF9 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 32kDa 2 3
- TAFII32 3 4 6
- TAF2G 3 4 6
- Transcription Initiation Factor TFIID 31 KDa Subunit 3 4
- Transcription Initiation Factor TFIID 32 KDa Subunit 3 4
- RNA Polymerase II TBP-Associated Factor Subunit G 3 4
- STAF31/32 3 4
- TAFII-31 3 4
External Ids for TAF9 Gene
Previous Symbols for TAF9 Gene
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds to the basal transcription factor GTF2B as well as to several transcriptional activators such as p53 and VP16. In human, TAF9 and AK6 (GeneID: 102157402) are two distinct genes that share 5' exons. A similar but distinct gene (TAF9L) has been found on the X chromosome and a pseudogene has been identified on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
GeneCards Summary for TAF9 Gene
TAF9 (TAF9 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 32kDa) is a Protein Coding gene. Among its related pathways are Disease and GPCR Pathway. GO annotations related to this gene include protein heterodimerization activity and transcription regulatory region DNA binding. An important paralog of this gene is TAF9B.
UniProtKB/Swiss-Prot for TAF9 Gene
Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription.