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Aliases for TAF9 Gene

Aliases for TAF9 Gene

  • TAF9 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 32kDa 2 3
  • TAFII32 3 4 6
  • TAF2G 3 4 6
  • Transcription Initiation Factor TFIID 31 KDa Subunit 3 4
  • Transcription Initiation Factor TFIID 32 KDa Subunit 3 4
  • RNA Polymerase II TBP-Associated Factor Subunit G 3 4
  • STAF31/32 3 4
  • TAFII-31 3 4
  • TAFII-32 3 4
  • TAFII31 3 4
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, G, 32kD 2
  • Transcription Initiation Factor TFIID 31 KD Subunit 3
  • Transcription Initiation Factor TFIID Subunit 9 3
  • MGC:5067 3
  • TAFIID32 3

External Ids for TAF9 Gene

Previous HGNC Symbols for TAF9 Gene

  • TAF2G

Previous GeneCards Identifiers for TAF9 Gene

  • GC05M068800
  • GC05M070213
  • GC05M068617
  • GC05M068663
  • GC05M068683
  • GC05M065603
  • GC05M068646

Summaries for TAF9 Gene

Entrez Gene Summary for TAF9 Gene

  • Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds to the basal transcription factor GTF2B as well as to several transcriptional activators such as p53 and VP16. In human, TAF9 and AK6 (GeneID: 102157402) are two distinct genes that share 5' exons. A similar but distinct gene (TAF9L) has been found on the X chromosome and a pseudogene has been identified on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for TAF9 Gene

TAF9 (TAF9 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 32kDa) is a Protein Coding gene. Among its related pathways are Disease and GPCR Pathway. GO annotations related to this gene include protein heterodimerization activity and transcription regulatory region DNA binding. An important paralog of this gene is TAF9B.

UniProtKB/Swiss-Prot for TAF9 Gene

  • Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription.

Gene Wiki entry for TAF9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF9 Gene

Genomics for TAF9 Gene

Regulatory Elements for TAF9 Gene

Transcription factor binding sites by QIAGEN in the TAF9 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TAF9 Gene

Start:
69,350,984 bp from pter
End:
69,370,013 bp from pter
Size:
19,030 bases
Orientation:
Minus strand

Genomic View for TAF9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAF9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF9 Gene

Proteins for TAF9 Gene

  • Protein details for TAF9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16594-TAF9_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 9
    Protein Accession:
    Q16594
    Secondary Accessions:
    • D3DWA3
    • Q5U0D1
    • Q9BTS1

    Protein attributes for TAF9 Gene

    Size:
    264 amino acids
    Molecular mass:
    28974 Da
    Quaternary structure:
    • Component of TFIID, the TATA-binding protein-free TAF complex (TFTC), the PCAF complex and the STAGA transcription coactivator-HAT complex. The PCAF complex consists at least of TADA2L/ADA2, SUPT3H/SPT3, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP. The STAGA transcription coactivator-HAT complex consists at least of SUPT3H, GCN5L2, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. Binds N-terminal domain of p53/TP53 which is essential for transcription. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Binds TFIIB and the Herpes simplex virus activator VP16. Forms a heterodimer with TAF6/TAFII80 in a complex with the TAF4B/TAFII105-TAF12/TAFII20 heterodimer. Also interacts with TAF5. Binds directly DNA. Increased DNA binding when complexed with TAF6/TAFII80.

neXtProt entry for TAF9 Gene

Proteomics data for TAF9 Gene at MOPED

Post-translational modifications for TAF9 Gene

  • Ubiquitination at Lys55 and Lys108
  • Modification sites at PhosphoSitePlus

Other Protein References for TAF9 Gene

No data available for DME Specific Peptides for TAF9 Gene

Domains for TAF9 Gene

Protein Domains for TAF9 Gene

Suggested Antigen Peptide Sequences for TAF9 Gene

Graphical View of Domain Structure for InterPro Entry

Q16594

UniProtKB/Swiss-Prot:

TAF9_HUMAN :
  • Q16594
Family:
  • Belongs to the TAF9 family.
genes like me logo Genes that share domains with TAF9: view

No data available for Gene Families for TAF9 Gene

Function for TAF9 Gene

Molecular function for TAF9 Gene

UniProtKB/Swiss-Prot Function: Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription.
UniProtKB/Swiss-Prot Induction: 6 to 8-fold by apoptotic signals.

Gene Ontology (GO) - Molecular Function for TAF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IPI 11278372
GO:0003677 DNA binding IDA 15601843
GO:0003713 transcription coactivator activity IMP 11278372
GO:0004017 adenylate kinase activity --
GO:0004402 contributes_to histone acetyltransferase activity IDA 11564863
genes like me logo Genes that share ontologies with TAF9: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAF9

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TAF9 Gene

Localization for TAF9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF9 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAF9 Gene COMPARTMENTS Subcellular localization image for TAF9 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for TAF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000125 PCAF complex IDA 9674425
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex IDA 14580349
GO:0015030 Cajal body --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with TAF9: view

Pathways for TAF9 Gene

genes like me logo Genes that share pathways with TAF9: view

Gene Ontology (GO) - Biological Process for TAF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0006325 chromatin organization TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with TAF9: view

Transcripts for TAF9 Gene

Unigene Clusters for TAF9 Gene

TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAF9

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAF9 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8 ^ 9a · 9b ^ 10
SP1: - - - - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - -
SP7: - -
SP8: -
SP9: - - - - - - -
SP10:

Relevant External Links for TAF9 Gene

GeneLoc Exon Structure for
TAF9
ECgene alternative splicing isoforms for
TAF9

Expression for TAF9 Gene

mRNA expression in normal human tissues for TAF9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TAF9 Gene

SOURCE GeneReport for Unigene cluster for TAF9 Gene Hs.653163

genes like me logo Genes that share expressions with TAF9: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TAF9 Gene

Orthologs for TAF9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAF9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF9 35
  • 99.6 (n)
  • 99.2 (a)
cow
(Bos Taurus)
Mammalia TAF9 35
  • 93.55 (n)
  • 96.77 (a)
TAF9 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAF9 35
  • 92.64 (n)
  • 98.39 (a)
TAF9 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taf9 35
  • 91.09 (n)
  • 96.36 (a)
Taf9 16
Taf9 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Taf9 35
  • 92.74 (n)
  • 95.97 (a)
chicken
(Gallus gallus)
Aves TAF9 35
  • 73.28 (n)
  • 85.83 (a)
TAF9 36
  • 86 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 85 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia taf9b 35
  • 75.2 (n)
  • 84.55 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3586 35
zebrafish
(Danio rerio)
Actinopterygii taf9 35
  • 71.69 (n)
  • 82.43 (a)
taf9 36
  • 81 (a)
OneToMany
wufb16h03 35
fruit fly
(Drosophila melanogaster)
Insecta e(y)1 36
  • 34 (a)
OneToMany
e(y)1 37
  • 56 (a)
worm
(Caenorhabditis elegans)
Secernentea taf-9 36
  • 31 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR527W 35
  • 46.72 (n)
  • 40.17 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FAP7 38
TAF9 35
  • 44.96 (n)
  • 34.11 (a)
TAF9 36
  • 29 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F25003g 35
  • 47.09 (n)
  • 34.92 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes taf9 35
  • 55.94 (n)
  • 44.35 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7568 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for TAF9:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAF9 Gene

ENSEMBL:
Gene Tree for TAF9 (if available)
TreeFam:
Gene Tree for TAF9 (if available)

Paralogs for TAF9 Gene

Paralogs for TAF9 Gene

Selected SIMAP similar genes for TAF9 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TAF9: view

Variants for TAF9 Gene

Sequence variations from dbSNP and Humsavar for TAF9 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_016279 -
VAR_052260 -

Structural Variations from Database of Genomic Variants (DGV) for TAF9 Gene

Variant ID Type Subtype PubMed ID
nsv821643 CNV Loss 15273396
nsv881767 CNV Loss 21882294
nsv881768 CNV Loss 21882294
nsv428117 CNV Gain+Loss 18775914

Relevant External Links for TAF9 Gene

HapMap Linkage Disequilibrium report
TAF9
Human Gene Mutation Database (HGMD)
TAF9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF9 Gene

Disorders for TAF9 Gene

(1) University of Copenhagen DISEASES for TAF9 Gene

Relevant External Links for TAF9

Genetic Association Database (GAD)
TAF9
Human Genome Epidemiology (HuGE) Navigator
TAF9
genes like me logo Genes that share disorders with TAF9: view

No data available for UniProtKB/Swiss-Prot for TAF9 Gene

Publications for TAF9 Gene

  1. Characterization of hCINAP, a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus. (PMID: 16079131) Santama N. … Lamond A.I. (J. Biol. Chem. 2005) 2 3 4 23
  2. Evolutionary conservation of human TATA-binding-polypeptide- associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors. (PMID: 7667268) Hisatake K. … Roeder R.G. (Proc. Natl. Acad. Sci. U.S.A. 1995) 3 4 23
  3. Potential targets for HSF1 within the preinitiation complex. (PMID: 11005381) Yuan C.X. … Gurley W.B. (Cell Stress Chaperones 2000) 3 23
  4. Stabilization and activation of p53 by the coactivator protein TAFII31. (PMID: 11278372) Buschmann T. … Wu X. (J. Biol. Chem. 2001) 3 23
  5. Quantitative assessment of in vitro interactions implicates TATA-binding protein as a target of the VP16C transcriptional activation region. (PMID: 15081896) Nedialkov Y.A. … Triezenberg S.J. (Arch. Biochem. Biophys. 2004) 3 23

Products for TAF9 Gene

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