Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TAF9 Gene

Aliases for TAF9 Gene

  • TATA-Box Binding Protein Associated Factor 9 2 3 5
  • TAF9 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 32kDa 2 3
  • Transcription Initiation Factor TFIID 31 KDa Subunit 3 4
  • Transcription Initiation Factor TFIID 32 KDa Subunit 3 4
  • RNA Polymerase II TBP-Associated Factor Subunit G 3 4
  • STAF31/32 3 4
  • TAFII-31 3 4
  • TAFII-32 3 4
  • TAFII31 3 4
  • TAFII32 3 4
  • TAF2G 3 4
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, G, 32kD 2
  • Transcription Initiation Factor TFIID 31 KD Subunit 3
  • Transcription Initiation Factor TFIID Subunit 9 3
  • MGC:5067 3
  • TAFIID32 3

External Ids for TAF9 Gene

Previous HGNC Symbols for TAF9 Gene

  • TAF2G

Previous GeneCards Identifiers for TAF9 Gene

  • GC05M068800
  • GC05M070213
  • GC05M068617
  • GC05M068663
  • GC05M068683
  • GC05M065603
  • GC05M068646

Summaries for TAF9 Gene

Entrez Gene Summary for TAF9 Gene

  • Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds to the basal transcription factor GTF2B as well as to several transcriptional activators such as p53 and VP16. In human, TAF9 and AK6 (GeneID: 102157402) are two distinct genes that share 5' exons. A similar but distinct gene (TAF9L) has been found on the X chromosome and a pseudogene has been identified on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for TAF9 Gene

TAF9 (TATA-Box Binding Protein Associated Factor 9) is a Protein Coding gene. Diseases associated with TAF9 include Spinocerebellar Ataxia 7. Among its related pathways are Formation of HIV elongation complex in the absence of HIV Tat and HIV Life Cycle. GO annotations related to this gene include protein heterodimerization activity and ATPase activity. An important paralog of this gene is TAF9B.

UniProtKB/Swiss-Prot for TAF9 Gene

  • Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription.

Gene Wiki entry for TAF9 Gene

Additional gene information for TAF9 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF9 Gene

Genomics for TAF9 Gene

Regulatory Elements for TAF9 Gene

Enhancers for TAF9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H069367 1.4 Ensembl ENCODE 0.7 +0.2 163 5 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 GTF2H2C CCDC125 RAD17 OCLN AK6 TAF9
GH05H069374 0.8 ENCODE 0.7 -5.0 -4968 0 HDGF TBL1XR1 RB1 BACH1 BMI1 ZNF316 ATF7 ETV6 IKZF2 SMARCA5 MARVELD2 CDK7 TAF9 AK6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAF9 on UCSC Golden Path with GeneCards custom track

Promoters for TAF9 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000182016 413 2801 PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 SLC30A9

Transcription factor binding sites by QIAGEN in the TAF9 gene promoter:

Genomic Location for TAF9 Gene

Chromosome:
5
Start:
69,364,743 bp from pter
End:
69,370,013 bp from pter
Size:
5,271 bases
Orientation:
Minus strand

Genomic View for TAF9 Gene

Genes around TAF9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF9 Gene

Proteins for TAF9 Gene

  • Protein details for TAF9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16594-TAF9_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 9
    Protein Accession:
    Q16594
    Secondary Accessions:
    • D3DWA3
    • Q5U0D1
    • Q9BTS1

    Protein attributes for TAF9 Gene

    Size:
    264 amino acids
    Molecular mass:
    28974 Da
    Quaternary structure:
    • Component of TFIID, the TATA-binding protein-free TAF complex (TFTC), the PCAF complex and the STAGA transcription coactivator-HAT complex. The PCAF complex consists at least of TADA2L/ADA2, SUPT3H/SPT3, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP. The STAGA transcription coactivator-HAT complex consists at least of SUPT3H, GCN5L2, SUPT7L, TAF5L, TAF6L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. Binds N-terminal domain of p53/TP53 which is essential for transcription. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Binds TFIIB and the Herpes simplex virus activator VP16. Forms a heterodimer with TAF6/TAFII80 in a complex with the TAF4B/TAFII105-TAF12/TAFII20 heterodimer. Also interacts with TAF5. Binds directly DNA. Increased DNA binding when complexed with TAF6/TAFII80.

neXtProt entry for TAF9 Gene

Post-translational modifications for TAF9 Gene

  • Ubiquitination at Lys108
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TAF9 Gene

Domains & Families for TAF9 Gene

Gene Families for TAF9 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TAF9 Gene

Suggested Antigen Peptide Sequences for TAF9 Gene

Graphical View of Domain Structure for InterPro Entry

Q16594

UniProtKB/Swiss-Prot:

TAF9_HUMAN :
  • Belongs to the TAF9 family.
Family:
  • Belongs to the TAF9 family.
genes like me logo Genes that share domains with TAF9: view

Function for TAF9 Gene

Molecular function for TAF9 Gene

UniProtKB/Swiss-Prot Function:
Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription.
UniProtKB/Swiss-Prot Induction:
6 to 8-fold by apoptotic signals.

Gene Ontology (GO) - Molecular Function for TAF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001075 contributes_to transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly IBA --
GO:0002039 p53 binding IPI 11278372
GO:0003677 DNA binding IEA,IDA 15601843
GO:0003713 transcription coactivator activity IMP 11278372
GO:0004402 contributes_to histone acetyltransferase activity IDA 9674425
genes like me logo Genes that share ontologies with TAF9: view

Phenotypes for TAF9 Gene

genes like me logo Genes that share phenotypes with TAF9: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TAF9
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAF9 Gene

Localization for TAF9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAF9 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
mitochondrion 2
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TAF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000124 SAGA complex IBA --
GO:0000125 PCAF complex IDA 9674425
GO:0005634 nucleus IDA,IEA 11564863
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex IDA 14580349
genes like me logo Genes that share ontologies with TAF9: view

Pathways & Interactions for TAF9 Gene

genes like me logo Genes that share pathways with TAF9: view

Gene Ontology (GO) - Biological Process for TAF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000492 box C/D snoRNP assembly IDA 17636026
GO:0006351 transcription, DNA-templated IEA --
GO:0006352 DNA-templated transcription, initiation IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with TAF9: view

No data available for SIGNOR curated interactions for TAF9 Gene

Drugs & Compounds for TAF9 Gene

(2) Drugs for TAF9 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
ATP Nutra Agonist 0

(1) Additional Compounds for TAF9 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with TAF9: view

Transcripts for TAF9 Gene

Unigene Clusters for TAF9 Gene

TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TAF9
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TAF9 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g ^ 8 ^ 9a · 9b ^ 10
SP1: - - - - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - -
SP6: - - -
SP7: - -
SP8: -
SP9: - - - - - - -
SP10:

Relevant External Links for TAF9 Gene

GeneLoc Exon Structure for
TAF9
ECgene alternative splicing isoforms for
TAF9

Expression for TAF9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAF9 Gene

Protein differential expression in normal tissues from HIPED for TAF9 Gene

This gene is overexpressed in Bone (23.4), Kidney (17.1), and Colon (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TAF9 Gene



Protein tissue co-expression partners for TAF9 Gene

NURSA nuclear receptor signaling pathways regulating expression of TAF9 Gene:

TAF9

SOURCE GeneReport for Unigene cluster for TAF9 Gene:

Hs.653163

Evidence on tissue expression from TISSUES for TAF9 Gene

  • Nervous system(4.3)
  • Adrenal gland(4.1)
genes like me logo Genes that share expression patterns with TAF9: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAF9 Gene

Orthologs for TAF9 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAF9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF9 33
  • 99.6 (n)
cow
(Bos Taurus)
Mammalia TAF9 33
  • 93.55 (n)
rat
(Rattus norvegicus)
Mammalia Taf9 33
  • 92.74 (n)
dog
(Canis familiaris)
Mammalia TAF9 33
  • 92.64 (n)
mouse
(Mus musculus)
Mammalia Taf9 33 16
  • 91.09 (n)
chicken
(Gallus gallus)
Aves TAF9 33
  • 73.28 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia taf9b 33
  • 75.2 (n)
zebrafish
(Danio rerio)
Actinopterygii taf9 33
  • 71.69 (n)
wufb16h03 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3586 33
fruit fly
(Drosophila melanogaster)
Insecta e(y)1 35
  • 56 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F25003g 33
  • 47.09 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR527W 33
  • 46.72 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF9 33 36
  • 44.96 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes taf9 33
  • 55.94 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7568 33
Species where no ortholog for TAF9 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAF9 Gene

ENSEMBL:
Gene Tree for TAF9 (if available)
TreeFam:
Gene Tree for TAF9 (if available)

Paralogs for TAF9 Gene

Paralogs for TAF9 Gene

(2) SIMAP similar genes for TAF9 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for TAF9 Gene

genes like me logo Genes that share paralogs with TAF9: view

Variants for TAF9 Gene

Sequence variations from dbSNP and Humsavar for TAF9 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs11542580 --
rs138054935 -- 69,371,437(+) TTCTT(-/CCC)CCCCC intron-variant, upstream-variant-2KB
rs34070239 -- 69,367,504(+) ATCTC(-/A/AA/AAA)AAAAA intron-variant, upstream-variant-2KB
rs4252233 --
rs751283583 -- 69,369,451(+) CGGCC(A/G)CGCGC intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TAF9 Gene

Variant ID Type Subtype PubMed ID
dgv5694n100 CNV gain 25217958
nsv428117 CNV gain+loss 18775914
nsv821643 CNV loss 15273396
nsv980655 CNV duplication 23825009

Variation tolerance for TAF9 Gene

Residual Variation Intolerance Score: 30.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.67; 31.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAF9 Gene

Human Gene Mutation Database (HGMD)
TAF9
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAF9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF9 Gene

Disorders for TAF9 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TAF9 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
spinocerebellar ataxia 7
  • spinocerebellar ataxia type 7
- elite association - COSMIC cancer census association via MalaCards
Search TAF9 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TAF9

Genetic Association Database (GAD)
TAF9
Human Genome Epidemiology (HuGE) Navigator
TAF9
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAF9
genes like me logo Genes that share disorders with TAF9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAF9 Gene

Publications for TAF9 Gene

  1. Characterization of hCINAP, a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus. (PMID: 16079131) Santama N … Lamond AI (The Journal of biological chemistry 2005) 2 3 4 22 60
  2. Evolutionary conservation of human TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors. (PMID: 7667268) Hisatake K … Roeder RG (Proceedings of the National Academy of Sciences of the United States of America 1995) 3 4 22 60
  3. STAGA recruits Mediator to the MYC oncoprotein to stimulate transcription and cell proliferation. (PMID: 17967894) Liu X … Martinez E (Molecular and cellular biology 2008) 3 22 60
  4. Multivalent binding of p53 to the STAGA complex mediates coactivator recruitment after UV damage. (PMID: 18250150) Gamper AM … Roeder RG (Molecular and cellular biology 2008) 3 22 60
  5. Core promoter binding by histone-like TAF complexes. (PMID: 15601843) Shao H … Dikstein R (Molecular and cellular biology 2005) 3 4 60

Products for TAF9 Gene

Sources for TAF9 Gene

Content
Loading form....