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TAF8 Gene

protein-coding   GIFtS: 54
GCID: GC06P042018

TAF8 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated...

(Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase...)
(Previous symbol: TBN)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TAF8 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated
Factor, 43kDa1 2
     Taube Nuss Homolog (Mouse)1
TBN1 2 3     432
TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, A,
45/50kDa1 2
     II2
Protein Taube Nuss2 3     TAF2
Transcription Initiation Factor TFIID 43 KDa Subunit2 3     TAF(II)432
TAFII-432 3     Taube Nuss Homolog2
TAFII432 3     TBP-Associated Factor TAFII432
hTAFII432 3     TBP-Associated Factor, RNA Polymerase II, 43 KD2
TBP-Associated Factor 43 KDa2 3     Transcription Initiation Factor TFIID Subunit 82
TBP-Associated Factor 82 3     

External Ids:    HGNC: 173001   Entrez Gene: 1296852   Ensembl: ENSG000001374137   OMIM: 6095145   UniProtKB: Q7Z7C83   

Export aliases for TAF8 gene to outside databases

Previous GC identifers: GC00U991138 GC06P042127 GC06P041736


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TAF8 Gene:
This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits
of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates
the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors.
The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of
TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been
described, but their biological validity has not been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for TAF8 Gene:
TAF8 (TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa) is a protein-coding gene. Diseases associated with TAF8 include hiv-1, and alzheimer's disease. GO annotations related to this gene include protein heterodimerization activity.

UniProtKB/Swiss-Prot: TAF8_HUMAN, Q7Z7C8
Function: Transcription factor TFIID is one of the general factors required for accurate and regulated initiation
by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the
differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in
differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for
survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By
similarity)

Gene Wiki entry for TAF8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TAF8 gene promoter:
         c-Fos   TBP   AP-1   TFIID   ATF-2   c-Jun   AP-2gamma   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAF8 promoter sequence
   Search Chromatin IP Primers for TAF8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAF8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.1   Ensembl cytogenetic band:  6p21.1   HGNC cytogenetic band: 6p21.1

TAF8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAF8 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P042018:  view genomic region     (about GC identifiers)

Start:
42,018,251 bp from pter      End:
42,055,199 bp from pter
Size:
36,949 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TAF8_HUMAN, Q7Z7C8 (See protein sequence)
Recommended Name: Transcription initiation factor TFIID subunit 8  
Size: 310 amino acids; 34262 Da
Subunit: TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts
with TBP, TAF1, TAF6, TAF10, TAF11 and TAF13. Component also of a small TAF complex (SMAT) containing TAF8, TAF10
and SUPT7L. Forms a heterodimer with TAF10. Interaction with TAF10 is mediated mainly via its histone fold domain
while interaction with SUPT7L is via its C-terminal region
Miscellaneous: 'Taube nuss' means "empty nut' in German
Sequence caution: Sequence=BAB71460.1; Type=Frameshift; Positions=240;
Secondary accessions: Q5T0K1 Q8N4R9 Q96M52
Alternative splicing: 3 isoforms:  Q7Z7C8-1   Q7Z7C8-2   Q7Z7C8-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TAF8: NX_Q7Z7C8

Explore proteomics data for TAF8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TAF8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_612639.2  
    ENSEMBL proteins: 
     ENSP00000362069   ENSP00000417867   ENSP00000411900   ENSP00000362073   ENSP00000417760  
     ENSP00000362068   ENSP00000418029   ENSP00000417738  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR006565 BTP
     IPR019473 TFIID_su8_C
     IPR009072 Histone-fold

    Graphical View of Domain Structure for InterPro Entry Q7Z7C8

    ProtoNet protein and cluster: Q7Z7C8

    UniProtKB/Swiss-Prot: TAF8_HUMAN, Q7Z7C8
    Domain: Ectopic expression of the histone fold domain acts as a dominant-negative mutant resulting in
    differentiation inhibition
    Similarity: Belongs to the TAF8 family
    Similarity: Contains 1 histone-fold domain


    TAF8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAF8_HUMAN, Q7Z7C8
    Function: Transcription factor TFIID is one of the general factors required for accurate and regulated initiation
    by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the
    differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in
    differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for
    survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By
    similarity)
    Induction: Induced with triglyceride accumulation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI15870280
    GO:0046982protein heterodimerization activity IEA--
         
    TAF8 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Taf8):
     embryogenesis  mortality/aging 

    TAF8 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TAF8
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    miRNA
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    hsa-mir-335-5p (MIRT017151), hsa-mir-93-5p (MIRT048755)

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    Selected qRT-PCR Assays for microRNAs that regulate TAF8 (see all 17):
    hsa-miR-520d-5p hsa-miR-340 hsa-miR-29b-1* hsa-miR-105 hsa-miR-3150b-3p hsa-miR-3121-3p hsa-miR-580 hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidTAF8 3' UTR sequence
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TAF8_HUMAN, Q7Z7C8: Nucleus. Cytoplasm (By similarity). Note=Localized in the cytoplasm and transported from the
    cytoplasm to the nucleus in some cells, possibly depending on the functional or developmental state of the cell
    (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005669transcription factor TFIID complex IDA14580349
    GO:0005730NOT nucleolus IDA--
    GO:0048471perinuclear region of cytoplasm IDA15870280

    TAF8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TAF8 About    
    See pathways by source

    SuperPathContained pathways About
    1Assembly of RNA Polymerase-II Initiation Complex
    Basal transcription factors0.50
    2Transcription Ligand Dependent Transcription of Retinoid Target genes
    Transcription Ligand Dependent Transcription of Retinoid Target genes

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for TAF8
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    1 Kegg Pathway  (Kegg details for TAF8):
        Basal transcription factors


    TAF8 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TAF8
    Interactions:

        GeneGlobe Interaction Network for TAF8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TAF8 (Q7Z7C83 ENSP000003620684) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAF9Q165943, ENSP000002178934I2D: score=2 STRING: ENSP00000370201 STRING: ENSP00000217893
    TAF5Q155423, ENSP000003588544I2D: score=3 STRING: ENSP00000358854
    TAF1P216753, ENSP000002760724I2D: score=2 STRING: ENSP00000276072
    TAF11Q155443, ENSP000003546334I2D: score=2 STRING: ENSP00000354633
    TAF2Q6P1X53, ENSP000003674064I2D: score=2 STRING: ENSP00000367406
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001833inner cell mass cell proliferation IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0030154cell differentiation IEA--
    GO:0045598regulation of fat cell differentiation IDA14580349
    GO:0045893positive regulation of transcription, DNA-templated IDA14580349

    TAF8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for TAF8



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TAF8 gene: 
    NM_138572.2  

    Unigene Cluster for TAF8:

    TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
    Hs.520122  [show with all ESTs]
    Unigene Representative Sequence: NM_138572
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372978(uc003orr.3) ENST00000494547 ENST00000456846 ENST00000372982(uc003oru.1 uc003orv.1)
    ENST00000472818 ENST00000372977(uc003ors.3 uc003ort.3 uc011dun.2)
    ENST00000486070 ENST00000482926 ENST00000465926 ENST00000482432
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TAF8 (see all 17):
    hsa-miR-520d-5p hsa-miR-340 hsa-miR-29b-1* hsa-miR-105 hsa-miR-3150b-3p hsa-miR-3121-3p hsa-miR-580 hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidTAF8 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TAF8
      QuantiFast Probe-based Assays in human, mouse, rat TAF8

    Additional mRNA sequence: 

    AF086309.1 AF465841.1 AK057383.1 AK303097.1 AL833401.1 BC119678.1 BC119679.1 

    16 DOTS entries:

    DT.100773233  DT.421486  DT.121342217  DT.108065  DT.97795211  DT.97846170  DT.40292936  DT.75145214 
    DT.95150036  DT.97846169  DT.121342110  DT.92036337  DT.95357755  DT.97812883  DT.97846168  DT.121342254 

    Selected AceView cDNA sequences (see all 128):

    BM758180 CD636440 BM758732 BM758910 BM741104 BM746812 BM749804 BI260232 
    CD514233 BM785433 BQ437299 BM755747 BM758091 CA430966 BM757582 BM758051 
    BM758085 BM756275 BU189966 CD636453 BF432334 BM741109 BM758728 AW815571 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TAF8 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                          -           -                 -                 -     -           -                                 
    SP2:                          -           -                 -                 -                                                   
    SP3:                          -           -                 -                                                                     
    SP4:                                      -                 -                                                                     
    SP5:                          -           -                                                                                       


    ECgene alternative splicing isoforms for TAF8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TAF8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGATTAAAA
    TAF8 Expression
    About this image


    TAF8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells
     
     Inner Cell Mass (Early Embryonic Tissues)
             Inner Cell Mass Cells Inner Cell Mass
     
     Brain (Nervous System)
             Neural progenitor cells
    TAF8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TAF8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.520122
        Custom PCR Arrays for TAF8
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TAF8 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Taf81 , 5 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated more1, 5 89.86(n)1
    95.61(a)1
      17 (23.33 cM)5
    638561  NM_022015.31  NP_071298.11 
     474880505 
    chicken
    (Gallus gallus)
    Aves TAF81 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated more 82.38(n)
    94.26(a)
      419929  NM_001030923.1  NP_001026094.1 
    lizard
    (Anolis carolinensis)
    Reptilia TAF86
    TAF8 RNA polymerase II, TATA box binding protein (...
    91(a)
    1 ↔ 1
    4(119140502-119150508)
    African clawed frog
    (Xenopus laevis)
    Amphibia tbn-prov2 taube nuss 77.06(n)    BC043877.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc564012 similar to taube nuss 74.7(n)   393256  BC049422.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Taf81 TBP-associated factor 8 51.77(n)
    44.7(a)
      32792  NM_078673.4  NP_523397.1 
    worm
    (Caenorhabditis elegans)
    Secernentea taf-86
    Protein TAF-8, isoform b (taf-8) mRNA, complete cd...
    13(a)
    1 ↔ 1
    II(9669324-9671499) WBGene00006390


    ENSEMBL Gene Tree for TAF8 (if available)
    TreeFam Gene Tree for TAF8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TAF8 (see all 718)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs606281721,2
    C--41766853(+) GTGTG-/GCGC/GT
    GC
    /TG/TGCG
    CGTGT
    1 -- ds50010--------
    rs624158931,2
    C--42018640(+) ATATTT/GAGCTT 1 -- int13Minor allele frequency- G:0.18NA EA 242
    rs77658901,2
    C,F,H--42018653(+) TTACTT/GTTTTG 1 -- int14Minor allele frequency- G:0.00NS EA 522
    rs77701491,2
    C,H--42018878(+) GGGACC/TGTACG 1 -- int112Minor allele frequency- T:0.02NA WA CSA EA 374
    rs119673781,2
    C,F,A,H--42018883(+) TGTACG/TTTTTA 1 -- int119Minor allele frequency- T:0.24NS EA NA WA 2522
    rs1826124491,2
    --42018906(+) AGTGGG/TCTCTG 1 -- int10--------
    rs1380167371,2
    --42018929(+) CTTGGA/GTGCTC 1 -- int10--------
    rs1495157141,2
    --42018936(+) GCTCAA/GTTTTT 1 -- int10--------
    rs2015853101,2
    F--42019037(+) CACGTA/GTGAAC 1 -- int11Minor allele frequency- G:0.00EU 593
    rs747104241,2
    C--42019120(+) CACTAA/CCCCTG 2 N T mis10--------

    HapMap Linkage Disequilibrium report for TAF8 (42018251 - 42055199 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TAF8:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731983CNV Deletion23290073
    nsv830646CNV Loss17160897
    nsv830649CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TAF8
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609514    OMIM disorders: --

    3 diseases for TAF8:    
    About MalaCards
    hiv-1    alzheimer's disease    malaria


    TAF8 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TAF8
    Human Genome Epidemiology (HuGE) Navigator: TAF8 (1 document)

    Export disorders for TAF8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TAF8 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with TAF8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a small TAF complex and its role in the assembly of TAF-containing complexes. (PubMed id 17375202)1, 2, 9 Demeny M.A.... Tora L. (PLoS ONE 2007)
    2. The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis. (PubMed id 14580349)1, 2, 9 Guermah M.... Roeder R.G. (Mol. Cell 2003)
    3. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)1, 4 Chapuis J....Lambert J.C. (Mol. Psychiatry 2009)
    4. The nuclear import of TAF10 is regulated by one of its three histone fold domain-containing interaction partners. (PubMed id 15870280)1, 2 Soutoglou E....Tora L. (Mol. Cell. Biol. 2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Genomics and transcription analysis of human TFIID. (PubMed id 9569032)1, 9 Purrello M....Roeder R. (Oncogene 1998)
    7. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    8. Human mediator subunit MED26 functions as a docking site for transcription elongation factors. (PubMed id 21729782)1 Takahashi H....Conaway J.W. (Cell 2011)
    9. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)
    10. STAGA recruits Mediator to the MYC oncoprotein to stimulate transcription and cell proliferation. (PubMed id 17967894)1 Liu X....Martinez E. (Mol. Cell. Biol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 129685 HGNC: 17300 AceView: TBN Ensembl:ENSG00000137413 euGenes: HUgn129685
    ECgene: TAF8 Kegg: 129685 H-InvDB: TAF8

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TAF8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TAF8 gene:
    Search GeneIP for patents involving TAF8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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