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Aliases for TAF8 Gene

Aliases for TAF8 Gene

  • TAF8 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 43kDa 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, A, 45/50kDa 2 3
  • Transcription Initiation Factor TFIID 43 KDa Subunit 3 4
  • TBP-Associated Factor 43 KDa 3 4
  • TBP-Associated Factor 8 3 4
  • Protein Taube Nuss 3 4
  • TAFII-43 3 4
  • HTAFII43 3 4
  • TAFII43 3 4
  • TBN 3 4
  • TBP-Associated Factor, RNA Polymerase II, 43 KD 3
  • Transcription Initiation Factor TFIID Subunit 8 3
  • TBP-Associated Factor TAFII43 3
  • Taube Nuss Homolog (Mouse) 2
  • Taube Nuss Homolog 3
  • TAF(II)43 3
  • TAF 3
  • II 3
  • 43 3

External Ids for TAF8 Gene

Previous HGNC Symbols for TAF8 Gene

  • TBN

Previous GeneCards Identifiers for TAF8 Gene

  • GC00U991138
  • GC06P042127
  • GC06P042018
  • GC06P041736

Summaries for TAF8 Gene

Entrez Gene Summary for TAF8 Gene

  • This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAF8 Gene

TAF8 (TAF8 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 43kDa) is a Protein Coding gene. Among its related pathways are Assembly of RNA Polymerase-II Initiation Complex and Transcription_Ligand-Dependent Transcription of Retinoid-Target genes. GO annotations related to this gene include protein heterodimerization activity.

UniProtKB/Swiss-Prot for TAF8 Gene

  • Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity).

Gene Wiki entry for TAF8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF8 Gene

Genomics for TAF8 Gene

Regulatory Elements for TAF8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TAF8 Gene

Start:
42,050,513 bp from pter
End:
42,087,461 bp from pter
Size:
36,949 bases
Orientation:
Plus strand

Genomic View for TAF8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAF8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF8 Gene

Proteins for TAF8 Gene

  • Protein details for TAF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7C8-TAF8_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 8
    Protein Accession:
    Q7Z7C8
    Secondary Accessions:
    • Q5T0K1
    • Q8N4R9
    • Q96M52

    Protein attributes for TAF8 Gene

    Size:
    310 amino acids
    Molecular mass:
    34262 Da
    Quaternary structure:
    • TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts with TBP, TAF1, TAF6, TAF10, TAF11 and TAF13. Component also of a small TAF complex (SMAT) containing TAF8, TAF10 and SUPT7L. Forms a heterodimer with TAF10. Interaction with TAF10 is mediated mainly via its histone fold domain while interaction with SUPT7L is via its C-terminal region.
    Miscellaneous:
    • Taube nuss means "empty nut in German
    SequenceCaution:
    • Sequence=BAB71460.1; Type=Frameshift; Positions=240; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TAF8 Gene

    Alternative splice isoforms for TAF8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAF8 Gene

Proteomics data for TAF8 Gene at MOPED

Post-translational modifications for TAF8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TAF8 Gene

Domains for TAF8 Gene

Protein Domains for TAF8 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q7Z7C8

UniProtKB/Swiss-Prot:

TAF8_HUMAN :
  • Q7Z7C8
Domain:
  • Ectopic expression of the histone fold domain acts as a dominant-negative mutant resulting in differentiation inhibition
  • Contains 1 histone-fold domain.
Family:
  • Belongs to the TAF8 family.
genes like me logo Genes that share domains with TAF8: view

No data available for Gene Families for TAF8 Gene

Function for TAF8 Gene

Molecular function for TAF8 Gene

UniProtKB/Swiss-Prot Function: Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity).
UniProtKB/Swiss-Prot Induction: Induced with triglyceride accumulation

Gene Ontology (GO) - Molecular Function for TAF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15870280
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with TAF8: view

Phenotypes for TAF8 Gene

genes like me logo Genes that share phenotypes with TAF8: view

Animal Model Products

miRNA for TAF8 Gene

miRTarBase miRNAs that target TAF8

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TAF8 Gene

Localization for TAF8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF8 Gene

Nucleus. Cytoplasm. Note=Localized in the cytoplasm and transported from the cytoplasm to the nucleus in some cells, possibly depending on the functional or developmental state of the cell. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAF8 Gene COMPARTMENTS Subcellular localization image for TAF8 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TAF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005669 transcription factor TFIID complex IDA 14580349
GO:0048471 perinuclear region of cytoplasm IDA 15870280
genes like me logo Genes that share ontologies with TAF8: view

Pathways for TAF8 Gene

genes like me logo Genes that share pathways with TAF8: view

Pathways by source for TAF8 Gene

1 KEGG pathway for TAF8 Gene
1 GeneGo (Thomson Reuters) pathway for TAF8 Gene

Gene Ontology (GO) - Biological Process for TAF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001833 inner cell mass cell proliferation IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0030154 cell differentiation IEA --
GO:0045598 regulation of fat cell differentiation IDA 14580349
GO:0045893 positive regulation of transcription, DNA-templated IDA 14580349
genes like me logo Genes that share ontologies with TAF8: view

Transcripts for TAF8 Gene

Unigene Clusters for TAF8 Gene

TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAF8

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TAF8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAF8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: - -
SP6: -
SP7: -
SP8: - -

Relevant External Links for TAF8 Gene

GeneLoc Exon Structure for
TAF8
ECgene alternative splicing isoforms for
TAF8

Expression for TAF8 Gene

mRNA expression in normal human tissues for TAF8 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAF8 Gene

SOURCE GeneReport for Unigene cluster for TAF8 Gene Hs.520122

genes like me logo Genes that share expressions with TAF8: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TAF8 Gene

Orthologs for TAF8 Gene

This gene was present in the common ancestor of animals.

Orthologs for TAF8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF8 35
  • 99.57 (n)
  • 100 (a)
TAF8 36
  • 80 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAF8 35
  • 92.58 (n)
  • 98.39 (a)
TAF8 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAF8 35
  • 91.72 (n)
  • 98.06 (a)
TAF8 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taf8 35
  • 89.86 (n)
  • 95.61 (a)
Taf8 16
Taf8 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 87 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TAF8 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Taf8 35
  • 89.19 (n)
  • 96.62 (a)
chicken
(Gallus gallus)
Aves TAF8 35
  • 82.38 (n)
  • 94.26 (a)
TAF8 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAF8 36
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia tbn-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5817 35
taf8 35
  • 73.14 (n)
  • 86.45 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2307 35
zebrafish
(Danio rerio)
Actinopterygii taf8 35
  • 69.05 (n)
  • 76.98 (a)
taf8 36
  • 74 (a)
OneToOne
zgc56401 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012105 35
  • 55.45 (n)
  • 53.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta sa 36
  • 24 (a)
OneToMany
Taf8 35
  • 51.77 (n)
  • 44.7 (a)
Taf8 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea taf-8 36
  • 13 (a)
OneToOne
Species with no ortholog for TAF8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAF8 Gene

ENSEMBL:
Gene Tree for TAF8 (if available)
TreeFam:
Gene Tree for TAF8 (if available)

Paralogs for TAF8 Gene

No data available for Paralogs for TAF8 Gene

Variants for TAF8 Gene

Sequence variations from dbSNP and Humsavar for TAF8 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1134218 -- 42,057,664(+) CCTGT(A/G)ATCCC intron-variant
rs2492918 -- 42,066,671(+) CTGGC(C/T)GCTTG intron-variant
rs2492925 -- 42,068,189(+) GCTGC(C/T)TGAGT intron-variant
rs2492926 -- 42,068,657(+) CGCAC(A/C)CTGCC intron-variant, downstream-variant-500B
rs2492927 -- 42,071,928(+) GCAAC(C/T)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAF8 Gene

Variant ID Type Subtype PubMed ID
nsv830646 CNV Loss 17160897
nsv830649 CNV Loss 17160897
esv2731983 CNV Deletion 23290073

Relevant External Links for TAF8 Gene

HapMap Linkage Disequilibrium report
TAF8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF8 Gene

Disorders for TAF8 Gene

Relevant External Links for TAF8

Genetic Association Database (GAD)
TAF8
Human Genome Epidemiology (HuGE) Navigator
TAF8
genes like me logo Genes that share disorders with TAF8: view

No data available for UniProtKB/Swiss-Prot for TAF8 Gene

Publications for TAF8 Gene

  1. The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis. (PMID: 14580349) Guermah M. … Roeder R.G. (Mol. Cell 2003) 3 4 23
  2. Identification of a small TAF complex and its role in the assembly of TAF-containing complexes. (PMID: 17375202) Demeny M.A. … Tora L. (PLoS ONE 2007) 3 4 23
  3. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PMID: 19204726) Chapuis J. … Lambert J.C. (Mol. Psychiatry 2009) 3 48
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The nuclear import of TAF10 is regulated by one of its three histone fold domain-containing interaction partners. (PMID: 15870280) Soutoglou E. … Tora L. (Mol. Cell. Biol. 2005) 3 4

Products for TAF8 Gene

Sources for TAF8 Gene

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