Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TAF8 Gene

Aliases for TAF8 Gene

  • TATA-Box Binding Protein Associated Factor 8 2 3 5
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, A, 45/50kDa 2 3
  • TAF8 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 43kDa 2 3
  • Transcription Initiation Factor TFIID 43 KDa Subunit 3 4
  • TBP-Associated Factor 43 KDa 3 4
  • TBP-Associated Factor 8 3 4
  • Protein Taube Nuss 3 4
  • TAFII-43 3 4
  • HTAFII43 3 4
  • TAFII43 3 4
  • TBN 3 4
  • TBP-Associated Factor, RNA Polymerase II, 43 KD 3
  • TATA Box Binding Protein Associated Factor 8 3
  • TBP-Associated Factor TAFII43 3
  • Taube Nuss Homolog (Mouse) 2
  • Taube Nuss Homolog 3
  • TAF(II)43 3
  • TAF 3
  • II 3

External Ids for TAF8 Gene

Previous HGNC Symbols for TAF8 Gene

  • TBN

Previous GeneCards Identifiers for TAF8 Gene

  • GC00U991138
  • GC06P042127
  • GC06P042018
  • GC06P041736

Summaries for TAF8 Gene

Entrez Gene Summary for TAF8 Gene

  • This gene encodes one of several TATA-binding protein (TBP)-associated factors (TAFs), which are integral subunits of the general transcription factor complex TFIID. TFIID recognizes the core promoter of many genes and nucleates the assembly of a transcription preinitiation complex containing RNA polymerase II and other initiation factors. The protein encoded by this gene contains an H4-like histone fold domain, and interacts with several subunits of TFIID including TBP and the histone-fold protein TAF10. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAF8 Gene

TAF8 (TATA-Box Binding Protein Associated Factor 8) is a Protein Coding gene. Among its related pathways are Gene Expression and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include protein heterodimerization activity.

UniProtKB/Swiss-Prot for TAF8 Gene

  • Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity).

Gene Wiki entry for TAF8 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF8 Gene

Genomics for TAF8 Gene

Regulatory Elements for TAF8 Gene

Promoters for TAF8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TAF8 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAF8 Gene

Chromosome:
6
Start:
42,050,513 bp from pter
End:
42,087,462 bp from pter
Size:
36,950 bases
Orientation:
Plus strand

Genomic View for TAF8 Gene

Genes around TAF8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF8 Gene

Proteins for TAF8 Gene

  • Protein details for TAF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7C8-TAF8_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 8
    Protein Accession:
    Q7Z7C8
    Secondary Accessions:
    • Q5T0K1
    • Q8N4R9
    • Q96M52

    Protein attributes for TAF8 Gene

    Size:
    310 amino acids
    Molecular mass:
    34262 Da
    Quaternary structure:
    • TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts with TBP, TAF1, TAF6, TAF10, TAF11 and TAF13. Component also of a small TAF complex (SMAT) containing TAF8, TAF10 and SUPT7L. Forms a heterodimer with TAF10. Interaction with TAF10 is mediated mainly via its histone fold domain while interaction with SUPT7L is via its C-terminal region.
    Miscellaneous:
    • Taube nuss means "empty nut in German.
    SequenceCaution:
    • Sequence=BAB71460.1; Type=Frameshift; Positions=240; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TAF8 Gene

    Alternative splice isoforms for TAF8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAF8 Gene

Proteomics data for TAF8 Gene at MOPED

Post-translational modifications for TAF8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TAF8 Gene

Domains & Families for TAF8 Gene

Protein Domains for TAF8 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q7Z7C8

UniProtKB/Swiss-Prot:

TAF8_HUMAN :
  • Ectopic expression of the histone fold domain acts as a dominant-negative mutant resulting in differentiation inhibition.
  • Belongs to the TAF8 family.
Domain:
  • Ectopic expression of the histone fold domain acts as a dominant-negative mutant resulting in differentiation inhibition.
  • Contains 1 histone-fold domain.
Family:
  • Belongs to the TAF8 family.
genes like me logo Genes that share domains with TAF8: view

No data available for Gene Families for TAF8 Gene

Function for TAF8 Gene

Molecular function for TAF8 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex. May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity).
UniProtKB/Swiss-Prot Induction:
Induced with triglyceride accumulation.
genes like me logo Genes that share phenotypes with TAF8: view

Animal Model Products

miRNA for TAF8 Gene

miRTarBase miRNAs that target TAF8

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAF8 Gene

Localization for TAF8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF8 Gene

Nucleus. Cytoplasm. Note=Localized in the cytoplasm and transported from the cytoplasm to the nucleus in some cells, possibly depending on the functional or developmental state of the cell. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAF8 Gene COMPARTMENTS Subcellular localization image for TAF8 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for TAF8 Gene

Pathways & Interactions for TAF8 Gene

genes like me logo Genes that share pathways with TAF8: view

Pathways by source for TAF8 Gene

1 KEGG pathway for TAF8 Gene
1 GeneGo (Thomson Reuters) pathway for TAF8 Gene

Gene Ontology (GO) - Biological Process for TAF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001833 inner cell mass cell proliferation IEA --
GO:0042795 snRNA transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with TAF8: view

No data available for SIGNOR curated interactions for TAF8 Gene

Drugs & Compounds for TAF8 Gene

No Compound Related Data Available

Transcripts for TAF8 Gene

Unigene Clusters for TAF8 Gene

TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAF8 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5: - -
SP6: -
SP7: -
SP8: - -

Relevant External Links for TAF8 Gene

GeneLoc Exon Structure for
TAF8
ECgene alternative splicing isoforms for
TAF8

Expression for TAF8 Gene

mRNA expression in normal human tissues for TAF8 Gene

Protein differential expression in normal tissues from HIPED for TAF8 Gene

This gene is overexpressed in Plasma (38.4) and Blymphocyte (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAF8 Gene



SOURCE GeneReport for Unigene cluster for TAF8 Gene Hs.520122

genes like me logo Genes that share expression patterns with TAF8: view

Protein tissue co-expression partners for TAF8 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TAF8 Gene

Orthologs for TAF8 Gene

This gene was present in the common ancestor of animals.

Orthologs for TAF8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TAF8 35
  • 92.58 (n)
  • 98.39 (a)
TAF8 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAF8 35
  • 91.72 (n)
  • 98.06 (a)
TAF8 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taf8 35
  • 89.86 (n)
  • 95.61 (a)
Taf8 16
Taf8 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TAF8 35
  • 99.57 (n)
  • 100 (a)
TAF8 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Taf8 35
  • 89.19 (n)
  • 96.62 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 87 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TAF8 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAF8 35
  • 82.38 (n)
  • 94.26 (a)
TAF8 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAF8 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5817 35
taf8 35
  • 73.14 (n)
  • 86.45 (a)
African clawed frog
(Xenopus laevis)
Amphibia tbn-prov 35
zebrafish
(Danio rerio)
Actinopterygii taf8 35
  • 69.05 (n)
  • 76.98 (a)
zgc56401 35
taf8 36
  • 74 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2307 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012105 35
  • 55.45 (n)
  • 53.96 (a)
fruit fly
(Drosophila melanogaster)
Insecta Taf8 35
  • 51.77 (n)
  • 44.7 (a)
sa 36
  • 24 (a)
OneToMany
Taf8 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea taf-8 36
  • 13 (a)
OneToOne
Species with no ortholog for TAF8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAF8 Gene

ENSEMBL:
Gene Tree for TAF8 (if available)
TreeFam:
Gene Tree for TAF8 (if available)

Paralogs for TAF8 Gene

No data available for Paralogs for TAF8 Gene

Variants for TAF8 Gene

Sequence variations from dbSNP and Humsavar for TAF8 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1134218 -- 42,057,664(+) CCTGT(A/G)ATCCC intron-variant
rs2492918 -- 42,066,671(+) CTGGC(C/T)GCTTG intron-variant
rs2492925 -- 42,068,189(+) GCTGC(C/T)TGAGT intron-variant
rs2492926 -- 42,068,657(+) CGCAC(A/C)CTGCC intron-variant, downstream-variant-500B
rs2492927 -- 42,071,928(+) GCAAC(C/T)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAF8 Gene

Variant ID Type Subtype PubMed ID
nsv830646 CNV Loss 17160897
nsv830649 CNV Loss 17160897
esv2731983 CNV Deletion 23290073

Variation tolerance for TAF8 Gene

Residual Variation Intolerance Score: 26.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.71; 15.11% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAF8 Gene

HapMap Linkage Disequilibrium report
TAF8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF8 Gene

Disorders for TAF8 Gene

Relevant External Links for TAF8

Genetic Association Database (GAD)
TAF8
Human Genome Epidemiology (HuGE) Navigator
TAF8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAF8

No disorders were found for TAF8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAF8 Gene

Publications for TAF8 Gene

  1. Identification of a small TAF complex and its role in the assembly of TAF-containing complexes. (PMID: 17375202) Demeny M.A. … Tora L. (PLoS ONE 2007) 3 4 23 67
  2. The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis. (PMID: 14580349) Guermah M. … Roeder R.G. (Mol. Cell 2003) 3 23
  3. Genomics and transcription analysis of human TFIID. (PMID: 9569032) Purrello M. … Roeder R. (Oncogene 1998) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3

Products for TAF8 Gene

Sources for TAF8 Gene

Back to Top

Content