TAF7L Gene
protein-coding GIFtS : 53
GC0XM100409
TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa (Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase II, Q )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbol: TAF2Q )
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Aliases & Descriptions for TAF7L
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases CT40 1 , 2 , 3 FLJ23157 2 OTTHUMP00000023675 2 TAF2Q 2 , 3 , 5 dJ738A13.1 2
Descriptions Cancer/testis antigen 40 2 , 3 RNA polymerase II TBP-associated factor subunit Q 3 TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50 kD 2 TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2 TAF7-like RNA polymerase II, TATA box binding protein-associated factor, 50kDa 1 TATA box binding protein (TBP)-associated factor, RNA polymerase II, Q 1 , 2 TATA box binding protein-associated factor, RNA polymerase II, Q 2 TATA box-binding protein-associated factor 50 kDa 3 TBP-associated factor, RNA polymerase II, Q 2 Transcription initiation factor TFIID 50 kDa subunit 3
Search outside databases for aliases for TAF7L genePrevious GC identifers: GC0XM095804 GC0XM097484 GC0XM098558 GC0XM099295 GC0XM100329
Summaries for TAF7L (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for TAF7L : This gene is similar to a mouse gene that encodes a TATA box binding protein-associated factor, andshows testis-specific expression. [provided by RefSeq] UniProtKB/Swiss-Prot: TAF7L_HUMAN, Q5H9L4 Function : Probably functions as a spermatogensis-specific component of the DNA-binding generaltranscription factor complex TFIID, a multimeric protein complex that plays a central role inmediating promoter responses to various activators and repressors. May play a role inspermatogenesis (By similarity)
Genomic Location for TAF7L
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the TAF7L gene Entrez Gene cytogenetic band: Xq22.1 Ensembl cytogenetic band: Xq22.1 HGNC cytogenetic band: Xq22.1 TAF7L Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XM100409:
(about GC identifiers )
Start:
100,409,897 bp from pter
End:
100,434,701 bp from pter
Size:
24,805 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000023.9 NT_011651.16 Proteins for TAF7L
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: TAF7L_HUMAN, Q5H9L4 (See
protein sequence )Recommended Name: Transcription initiation factor TFIID subunit 7-like Size : 462 amino acids; 52588 Da
Subunit : TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors(TAFs). TAF7L may replace TAF7 in a spermatogenensis-specific form of TFIID. Interacts with TBP;the interaction occurs in a sub-population of cells (pachytene and haploid round spermatids) andis developmentally regulated through differential intracellular localization of the two proteins.Interacts with TAF1 (By similarity)
Subcellular location : Nucleus (By similarity). Cytoplasm (By similarity). Note=Cytoplasmic inspermatogonia and early spermatocytes (preleptotene, leptotene, and zygotene); translocates intothe nuclei of pachytene spermatocytes and round spermatids (By similarity)
Secondary accessions : Q5H9L6 Q86XI4 Q9BXU5 Q9H5R0Alternative splicing : 3 isoforms : Q5H9L4-1 Q5H9L4-2 Q5H9L4-3
REFSEQ proteins: NP_079161.2 ENSEMBL proteins: ENSP00000349235 ENSP00000361998 ENSP00000361996 ENSP00000320283 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 4 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for TAF7L: Assays for TAF7L:
Protein
Domains/ Families for TAF7L(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q5H9L4 ProtoNet protein and cluster: Q5H9L4
1 Blocks protein family : IPB006751 TAFII55 protein conserved region UniProtKB/Swiss-Prot: TAF7L_HUMAN, Q5H9L4 Similarity : Belongs to the TAF7 family
Gene Function for TAF7L
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
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Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024885 Applied Biosystems Silencer ® siRNAs for TAF7L Sigma-Aldrich siRNA for TAF7L Sigma-Aldrich shRNA for TAF7L Explore Sigma-Aldrich super-pooled esiRNAs               OriGene GFP tagged cDNA clone in CMV expression vector: NM_024885                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_024885                                  untagged cDNA clone in CMV expression vector: NM_024885  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_024885 UniProtKB/Swiss-Prot: TAF7L_HUMAN, Q5H9L4 Function : Probably functions as a spermatogensis-specific component of the DNA-binding generaltranscription factor complex TFIID, a multimeric protein complex that plays a central role inmediating promoter responses to various activators and repressors. May play a role inspermatogenesis (By similarity)
2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Taf7l) :1 Gene Ontology (GO) molecular function term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0016251 general RNA polymerase II transcription factor activity
IEA --
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Pathways & Interactions for TAF7L
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for TAF7L (Your Favorite Gene powered by Ingenuity) Gene Network CentralTM Interacting Genes and Proteins Network for TAF7L 3 Interacting proteins for TAF7L (ENSP00000361998 3 ) via UniProtKB, MINT, and/or STRING About this table 5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6
):
GO ID Qualified GO term Evidence PubMed IDs GO:0006350 transcription
IEA -- GO:0006355 regulation of transcription, DNA-dependent
IEA -- GO:0006367 transcription initiation from RNA polymerase II promoter
IEA -- GO:0007275 multicellular organismal development
IEA -- GO:0007283 spermatogenesis
IEA --
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Drugs & Compounds for TAF7L (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Transcripts for TAF7L(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
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shRNA from
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_024885 Sigma-Aldrich siRNA for TAF7L Sigma-Aldrich shRNA for TAF7L Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_024885
REFSEQ mRNAs for TAF7L gene: NM_024885.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_024885
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_024885                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_024885                                  untagged cDNA clone in CMV expression vector: NM_024885  
Additional cDNA sequence: AF285595.1 AK026810.1 AK308261.1 BC043391.1
3 DOTS entries : DT.95341214 DT.121312664 DT.95351052
23 AceView cDNA sequences :BC043391 AI699474 AA902216 AI962851 AW590415 AI220545 AW236846 NM_024885 AI190862 AA885108 AW117310 AK026810 AW183175 AI950228 AA401392 BE504739 AA405087 BX100254 AA401416 AF285595 AI025202 BF508107 AW235517
highest scoring ESTs for TAF7L :BC043391 AA401416 AA405087 AK026810 NM_024885 AA401392 AA885108 AA902216 AI025202 AI190862
Unigene Cluster for TAF7L: TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa Hs.223806 [show with all ESTs ] Unigene Representative Sequence: BC043391 GeneLoc Exon Structure 4 Ensembl transcripts including schematic representations : ENST00000356784
ENST00000372907
ENST00000372905
ENST00000324762
Expression for TAF7L
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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TAF7L expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for TAF7L 1 / 2 / 3
5 probe-sets matching TAF7L gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CTTCTAAAGGSOURCE GeneReport for Unigene cluster: Hs.223806 UniProtKB/Swiss-Prot: TAF7L_HUMAN, Q5H9L4 Tissue specificity : Testis-specific
Orthologs for TAF7L
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for TAF7L gene from 5/6 species (see all 6
)
About this table Species with no ortholog for TAF7L ENSEMBL Gene Tree for TAF7L Paralogs for TAF7L (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for TAF7L gene TAF7 2
SNPs/Variants for TAF7L (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for TAF7L (up to first 250kb)
Disorders & Mutations for TAF7L
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 300314 Human Gene Mutation Database : TAF7L
Medical News for TAF7L (Possibly Related Articles in
Doctor's Guide )
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Publications for TAF7L (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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9 PubMed articles for TAF7L gene : An abundance of X-linked genes expressed in spermatogonia. (PubMed id 11279525) 2, 3, 4 Wang P.J....Page D.C. (2001) Mutation analysis of the X-chromosome linked, testis-specific TAF7L gene in spermatogenic failure. (PubMed id 17714218) 3, 4 Akinloye O.... Simoni M. (2007) The role of the testis-specific gene hTAF7L in the aetiology of male infertility. (PubMed id 16597641) 3, 4 Stouffs K....Liebaers I. (2006) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 3 Barbe L....Andersson-Svahn H. (2008) The DNA sequence of the human X chromosome. (PubMed id 15772651) 4 Ross M.T.... Bentley D.R. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 4 Ota T....Sugano S. (2004) The intracellular localisation of TAF7L, a paralogue of transcription factor TFIID subunit TAF7, is developmentally regulated during male germ-cell differentiation. (PubMed id 12665565) 3 Pointud J.C....Davidson I. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002)
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Aliases
TAF7L (Gene Symbol) CT40 FLJ23157 OTTHUMP00000023675 TAF2Q dJ738A13.1 Cancer/testis antigen 40 RNA polymerase II TBP-associated factor subunit Q TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50 kD TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa TAF7-like RNA polymerase II, TATA box binding protein-associated factor, 50kDa TATA box binding protein (TBP)-associated factor, RNA polymerase II, Q TATA box binding protein-associated factor, RNA polymerase II, Q TATA box-binding protein-associated factor 50 kDa TBP-associated factor, RNA polymerase II, Q Transcription initiation factor TFIID 50 kDa subunit
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Genome Databases showing TAF7L
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing TAF7L
(According to HUGE )
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Specialized Databases showing TAF7L (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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