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Aliases for TAF7L Gene

Aliases for TAF7L Gene

  • TATA-Box Binding Protein Associated Factor 7 Like 2 3 5
  • Cancer/Testis Antigen 40 2 3 4
  • TAF7-Like RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 50kDa 2 3
  • Transcription Initiation Factor TFIID 50 KDa Subunit 3 4
  • RNA Polymerase II TBP-Associated Factor Subunit Q 3 4
  • TATA Box-Binding Protein-Associated Factor 50 KDa 3 4
  • TAF2Q 3 4
  • CT40 3 4
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, Q 2
  • TATA Box Binding Protein Associated Factor 7 Like 3
  • TBP-Associated Factor, RNA Polymerase II, Q 3

External Ids for TAF7L Gene

Previous HGNC Symbols for TAF7L Gene

  • TAF2Q

Previous GeneCards Identifiers for TAF7L Gene

  • GC0XM095804
  • GC0XM097484
  • GC0XM098558
  • GC0XM099295
  • GC0XM100329
  • GC0XM100409
  • GC0XM100523
  • GC0XM090326

Summaries for TAF7L Gene

Entrez Gene Summary for TAF7L Gene

  • This gene is similar to a mouse gene that encodes a TATA box binding protein-associated factor, and shows testis-specific expression. The encoded protein could be a spermatogenesis-specific component of the DNA-binding general transcription factor complex TFIID. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

GeneCards Summary for TAF7L Gene

TAF7L (TATA-Box Binding Protein Associated Factor 7 Like) is a Protein Coding gene. Diseases associated with TAF7L include mohr-tranebjaerg syndrome. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Assembly of RNA Polymerase-II Initiation Complex. GO annotations related to this gene include transcription factor binding and transcription regulatory region DNA binding. An important paralog of this gene is TAF7.

UniProtKB/Swiss-Prot for TAF7L Gene

  • Probably functions as a spermatogensis-specific component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. May play a role in spermatogenesis (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF7L Gene

Genomics for TAF7L Gene

Regulatory Elements for TAF7L Gene

Enhancers for TAF7L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TAF7L on UCSC Golden Path with GeneCards custom track

Genomic Location for TAF7L Gene

Chromosome:
X
Start:
101,268,253 bp from pter
End:
101,293,071 bp from pter
Size:
24,819 bases
Orientation:
Minus strand

Genomic View for TAF7L Gene

Genes around TAF7L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF7L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF7L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF7L Gene

Proteins for TAF7L Gene

  • Protein details for TAF7L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5H9L4-TAF7L_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 7-like
    Protein Accession:
    Q5H9L4
    Secondary Accessions:
    • Q5H9L6
    • Q86XI4
    • Q9BXU5
    • Q9H5R0

    Protein attributes for TAF7L Gene

    Size:
    462 amino acids
    Molecular mass:
    52588 Da
    Quaternary structure:
    • TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TAF7L may replace TAF7 in a spermatogenesis-specific form of TFIID. Interacts with TBP; the interaction occurs in a sub-population of cells (pachytene and haploid round spermatids) and is developmentally regulated through differential intracellular localization of the two proteins. Interacts with TAF1 (By similarity).

    Alternative splice isoforms for TAF7L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAF7L Gene

Proteomics data for TAF7L Gene at MOPED

Post-translational modifications for TAF7L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAF7L Gene

No data available for DME Specific Peptides for TAF7L Gene

Domains & Families for TAF7L Gene

Protein Domains for TAF7L Gene

Suggested Antigen Peptide Sequences for TAF7L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5H9L4

UniProtKB/Swiss-Prot:

TAF7L_HUMAN :
  • Belongs to the TAF7 family.
Family:
  • Belongs to the TAF7 family.
genes like me logo Genes that share domains with TAF7L: view

No data available for Gene Families for TAF7L Gene

Function for TAF7L Gene

Molecular function for TAF7L Gene

UniProtKB/Swiss-Prot Function:
Probably functions as a spermatogensis-specific component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. May play a role in spermatogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for TAF7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035035 histone acetyltransferase binding IBA --
GO:0044212 transcription regulatory region DNA binding IBA --
genes like me logo Genes that share ontologies with TAF7L: view
genes like me logo Genes that share phenotypes with TAF7L: view

Animal Models for TAF7L Gene

MGI Knock Outs for TAF7L:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TAF7L Gene

Localization for TAF7L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF7L Gene

Nucleus. Cytoplasm. Note=Cytoplasmic in spermatogonia and early spermatocytes (preleptotene, leptotene, and zygotene); translocates into the nuclei of pachytene spermatocytes and round spermatids. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAF7L Gene COMPARTMENTS Subcellular localization image for TAF7L gene
Compartment Confidence
nucleus 5
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for TAF7L Gene

Pathways & Interactions for TAF7L Gene

genes like me logo Genes that share pathways with TAF7L: view

Gene Ontology (GO) - Biological Process for TAF7L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter IEA --
GO:0007275 multicellular organism development IEA --
GO:0008150 biological_process ND --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TAF7L: view

No data available for SIGNOR curated interactions for TAF7L Gene

Drugs & Compounds for TAF7L Gene

No Compound Related Data Available

Transcripts for TAF7L Gene

Unigene Clusters for TAF7L Gene

TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAF7L Gene

No ASD Table

Relevant External Links for TAF7L Gene

GeneLoc Exon Structure for
TAF7L
ECgene alternative splicing isoforms for
TAF7L

Expression for TAF7L Gene

mRNA expression in normal human tissues for TAF7L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TAF7L Gene

This gene is overexpressed in Testis (x31.9).

Protein differential expression in normal tissues from HIPED for TAF7L Gene

This gene is overexpressed in Testis (67.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAF7L Gene



SOURCE GeneReport for Unigene cluster for TAF7L Gene Hs.223806

mRNA Expression by UniProt/SwissProt for TAF7L Gene

Q5H9L4-TAF7L_HUMAN
Tissue specificity: Testis-specific.
genes like me logo Genes that share expression patterns with TAF7L: view

Protein tissue co-expression partners for TAF7L Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for TAF7L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAF7L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TAF7L 35
  • 79 (n)
  • 62.76 (a)
TAF7L 36
  • 56 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAF7L 35
  • 80.01 (n)
  • 67.32 (a)
TAF7L 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taf7l 35
  • 68.46 (n)
  • 52.13 (a)
Taf7l 16
4933416C03Rik 36
  • 58 (a)
OneToMany
Taf7l 36
  • 48 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia TAF7L 35
  • 99.25 (n)
  • 98.08 (a)
TAF7L 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Taf7l 35
  • 69.66 (n)
  • 54.61 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 37 (a)
OneToMany
-- 36
  • 46 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Taf7 36
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea taf-7.1 36
  • 26 (a)
ManyToMany
taf-7.2 36
  • 29 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF7 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.8232 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 38 (a)
OneToMany
Species with no ortholog for TAF7L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TAF7L Gene

ENSEMBL:
Gene Tree for TAF7L (if available)
TreeFam:
Gene Tree for TAF7L (if available)

Paralogs for TAF7L Gene

Paralogs for TAF7L Gene

(1) SIMAP similar genes for TAF7L Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TAF7L: view

Variants for TAF7L Gene

Sequence variations from dbSNP and Humsavar for TAF7L Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs5951328 - 101,292,945(+) CGACA(A/G)GAATT upstream-variant-2KB, reference, missense
rs147493489 - 101,292,865(+) GTCCT(C/T)GTCGG upstream-variant-2KB, reference, missense
rs35899692 - 101,277,633(+) GTGGC(C/T)GCTCA reference, missense
rs41310729 - 101,269,209(+) GAAAA(C/T)GCTGC reference, missense
rs747747414 -- 101,292,937(+) CCCAC(A/G)GTCGA upstream-variant-2KB, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TAF7L Gene

Variant ID Type Subtype PubMed ID
nsv524411 CNV Loss 19592680

Variation tolerance for TAF7L Gene

Residual Variation Intolerance Score: 25% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.02; 75.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAF7L Gene

HapMap Linkage Disequilibrium report
TAF7L
Human Gene Mutation Database (HGMD)
TAF7L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF7L Gene

Disorders for TAF7L Gene

MalaCards: The human disease database

(1) MalaCards diseases for TAF7L Gene - From: DISEASES

Disorder Aliases PubMed IDs
mohr-tranebjaerg syndrome
  • jensen syndrome
- elite association - COSMIC cancer census association via MalaCards
Search TAF7L in MalaCards View complete list of genes associated with diseases

Relevant External Links for TAF7L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAF7L
genes like me logo Genes that share disorders with TAF7L: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAF7L Gene

Publications for TAF7L Gene

  1. An abundance of X-linked genes expressed in spermatogonia. (PMID: 11279525) Wang P.J. … Page D.C. (Nat. Genet. 2001) 2 3 4 67
  2. Cancer/Testis OIP5 and TAF7L Genes are Up-Regulated in Breast Cancer. (PMID: 26107214) Mobasheri M.B. … Modarressi M.H. (Asian Pac. J. Cancer Prev. 2015) 3
  3. Frameshift mutations of TAF7L gene, a core component for transcription by RNA polymerase II, in colorectal cancers. (PMID: 25098277) Oh H.R. … Lee S.H. (Pathol. Oncol. Res. 2015) 3
  4. Expression analysis of four testis-specific genes AURKC, OIP5, PIWIL2 and TAF7L in acute myeloid leukemia: a gender-dependent expression pattern. (PMID: 23292864) Yazarloo F. … Modarressi M.H. (Med. Oncol. 2013) 3
  5. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3

Products for TAF7L Gene

Sources for TAF7L Gene

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