TAF7 Gene
protein-coding GIFtS : 57
GC05M140678
TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa (Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase II, F, 55kD )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbol: TAF2F )
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Aliases & Descriptions for TAF7
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases OTTHUMP00000160028 2 TAF(II)55 3 TAF2F 2 , 3 , 5 TAFII-55 3 TAFII55 1 , 2 , 3 , 5
Descriptions RNA polymerase II TBP-associated factor subunit F 3 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55 kD 2 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa 2 TAF7 RNA polymerase II, TATA box binding protein-associated factor, 55kDa 1 TATA box binding protein (TBP)-associated factor, RNA polymerase II, F, 55kD 1 , 2 TATA box-binding protein-associated factor 2F 2 TBP-associated factor F 2 Transcription initiation factor TFIID 55 kDa subunit 3 transcription factor IID subunit TAFII55 2 transcription initiation factor TFIID, 55 kDa subunit 2
Search outside databases for aliases for TAF7 genePrevious GC identifers: GC05M140514 GC05M141281 GC05M140681 GC05M140726
Summaries for TAF7 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for TAF7 : The intronless gene for this transcription coactivator is located between the protocadherin betaand gamma gene clusters on chromosome 5. The protein encoded by this gene is a component of theTFIID protein complex, a complex which binds to the TATA box in class II promoters and recruitsRNA polymerase II and other factors. This particular subunit interacts with the largest TFIIDsubunit, as well as multiple transcription activators. The protein is required for transcriptionby promoters targeted by RNA polymerase II. [provided by RefSeq] UniProtKB/Swiss-Prot: TAF7_HUMAN, Q15545 Function : Functions as a component of the DNA-binding general transcription factor complex TFIID, amultimeric protein complex that plays a central role in mediating promoter responses to variousactivators and repressors. Present in both of the previously described TFIID species which eitherlack or contain TAFII30 (TFIID alpha and TFIID beta respectively)
Gene Wiki entry for TAF7
Genomic Location for TAF7
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the TAF7 gene Entrez Gene cytogenetic band: 5q31 Ensembl cytogenetic band: 5q31.3 HGNC cytogenetic band: 5q31 TAF7 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure
GeneLoc location for GC05M140678:
(about GC identifiers )
Start:
140,678,239 bp from pter
End:
140,680,571 bp from pter
Size:
2,333 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000005.8 NT_029289.10 Proteins for TAF7
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: TAF7_HUMAN, Q15545 (See
protein sequence )Recommended Name: Transcription initiation factor TFIID subunit 7 Size : 349 amino acids; 40259 Da
Subunit : TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors(TAFs). Interacts with TAFII250, TAFII100, TAFII28, TAFII20, and TAFII18, but not with TAFII30 orTBP
Subcellular location : Nucleus
Secondary accessions : Q13036
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins: NP_005633.2 ENSEMBL proteins: ENSP00000312709 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: TAF7 5 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for TAF7: Assays for TAF7:
Protein
Domains/ Families for TAF7(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q15545 ProtoNet protein and cluster: Q15545
1 Blocks protein family : IPB006751 TAFII55 protein conserved region UniProtKB/Swiss-Prot: TAF7_HUMAN, Q15545 Domain : The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase, whichmethylates Lys-5 in vitro (By similarity) Similarity : Belongs to the TAF7 family
Gene Function for TAF7
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
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Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005642 Applied Biosystems Silencer ® siRNAs for TAF7 Sigma-Aldrich siRNA for TAF7 Sigma-Aldrich shRNA for TAF7 Explore Sigma-Aldrich super-pooled esiRNAs               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005642                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005642                                  untagged cDNA clone in CMV expression vector: NM_005642  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005642 UniProtKB/Swiss-Prot: TAF7_HUMAN, Q15545 Function : Functions as a component of the DNA-binding general transcription factor complex TFIID, amultimeric protein complex that plays a central role in mediating promoter responses to variousactivators and repressors. Present in both of the previously described TFIID species which eitherlack or contain TAFII30 (TFIID alpha and TFIID beta respectively)
3 Gene Ontology (GO) molecular function terms (links to tree view) :
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Pathways & Interactions for TAF7
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for TAF7 (Your Favorite Gene powered by Ingenuity) Gene Network CentralTM Interacting Genes and Proteins Network for TAF7 5/76 Interacting proteins for TAF7 (ENSP00000312709 3 ) via UniProtKB, MINT, and/or STRING (see all 76
)About this table 4 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006350 transcription
IEA -- GO:0006355 regulation of transcription, DNA-dependent
IEA -- GO:0006367 transcription initiation from RNA polymerase II promoter
IEA -- GO:0030520 estrogen receptor signaling pathway
IEA --
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Drugs & Compounds for TAF7 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Transcripts for TAF7(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005642 Sigma-Aldrich siRNA for TAF7 Sigma-Aldrich shRNA for TAF7 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_005642
REFSEQ mRNAs for TAF7 gene: NM_005642.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005642
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005642                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005642                                  untagged cDNA clone in CMV expression vector: NM_005642  
Additional cDNA sequence: AK314837.1 BC013397.2 BC022798.1 BC032737.1 U18062.1 X97999.1
16 DOTS entries : DT.95316543 DT.87017021 DT.91766955 DT.120808887 DT.120808871 DT.95136133 DT.100826252 DT.87017022 DT.120808882 DT.120808893 DT.120808895 DT.418489 DT.91766950 DT.95316545 DT.120808886 DT.95316499
highest scoring ESTs for TAF7 :U18062 AA036649 AA252724 AA278660 AA312894 AA326994 AA328618 AA336858 AA369696 AA372836
Unigene Cluster for TAF7: TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa Hs.438838 [show with all ESTs ] Unigene Representative Sequence: NM_005642 GeneLoc Exon Structure 1 Ensembl transcript including schematic representation : ENST00000313368
Expression for TAF7
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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TAF7 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for TAF7 1 / 2 / 3
3 probe-sets matching TAF7 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: AAAGTGGAAASOURCE GeneReport for Unigene cluster: Hs.438838 Expression variation in blood from EXPOLDB for TAF7
UniProtKB/Swiss-Prot: TAF7_HUMAN, Q15545 Tissue specificity : Ubiquitous
Orthologs for TAF7
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for TAF7 gene from 5/15 species (see all 15
)
About this table Species with no ortholog for TAF7 ENSEMBL Gene Tree for TAF7 Paralogs for TAF7 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for TAF7 gene TAF7L 2
SNPs/Variants for TAF7 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for TAF7 (up to first 250kb)
Disorders & Mutations for TAF7
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 600573
Medical News for TAF7 (Possibly Related Articles in
Doctor's Guide )
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Publications for TAF7 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/40 PubMed articles for TAF7 gene (see all 40
): Cloning of an intrinsic human TFIID subunit that interacts with multiple transcriptional activators. (PubMed id 7824954) 2, 3, 4 Chiang C.-M. and Roeder R.G. (1995) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 3, 4 Olsen J.V....Mann M. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) The intronless and TATA-less human TAFII55 gene contains a functional initiator and a downstream promoter element. (PubMed id 11340078) 3, 4 Zhou T. and Chiang C.-M. (2001) Multiple interactions between hTAFII55 and other TFIID subunits. Requirements for the formation of stable ternary complexes between hTAFII55 and the TATA-binding protein. (PubMed id 8702684) 3, 4 Lavigne A.C.... Davidson I. (1996) TAF7: a possible transcription initiation check-point regulator. (PubMed id 16407123) 1, 3 Gegonne A....Singer D.S. (2006) TFIID component TAF7 functionally interacts with both TFIIH and P-TEFb. (PubMed id 18391197) 1, 3 Gegonne A....Singer D.S. (2008) TATA-binding protein-associated factor 7 regulates polyamine transport activity and polyamine analog-induced apoptosis. (PubMed id 15078871) 1, 3 Fukuchi J....Liao S. (2004) Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976) 4 Daub H.... Mann M. (2008) A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648) 4 Dephoure N.... Gygi S.P. (2008)
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Aliases
TAF7 (Gene Symbol) OTTHUMP00000160028 TAF(II)55 TAF2F TAFII-55 TAFII55 RNA polymerase II TBP-associated factor subunit F TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55 kD TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa TAF7 RNA polymerase II, TATA box binding protein-associated factor, 55kDa TATA box binding protein (TBP)-associated factor, RNA polymerase II, F, 55kD TATA box-binding protein-associated factor 2F TBP-associated factor F Transcription initiation factor TFIID 55 kDa subunit transcription factor IID subunit TAFII55 transcription initiation factor TFIID, 55 kDa subunit
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Genome Databases showing TAF7
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing TAF7
(According to HUGE )
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Specialized Databases showing TAF7 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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