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TAF7 Gene

protein-coding   GIFtS: 62
GCID: GC05M140678

TAF7 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated...

(Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase...)
(Previous symbol: TAF2F)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TAF7 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated
Factor, 55kDa1 2
     TAFII-552 3
TAF2F1 2 3 5     RNA Polymerase II TBP-Associated Factor Subunit F2 3
TAFII552 3 5     TBP-Associated Factor F2
TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, F,
55kD1 2
     Transcription Factor IID Subunit TAFII552
Transcription Initiation Factor TFIID 55 KDa Subunit2 3     Transcription Initiation Factor TFIID Subunit 72
TAF(II)552 3     Transcription Initiation Factor TFIID, 55 KDa Subunit2

External Ids:    HGNC: 115411   Entrez Gene: 68792   Ensembl: ENSG000001789137   OMIM: 6005735   UniProtKB: Q155453   

Export aliases for TAF7 gene to outside databases

Previous GC identifers: GC05M140514 GC05M141281 GC05M140681 GC05M140726 GC05M135843


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TAF7 Gene:
The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene
clusters on chromosome 5. The protein encoded by this gene is a component of the TFIID protein complex, a complex
which binds to the TATA box in class II promoters and recruits RNA polymerase II and other factors. This
particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators. The
protein is required for transcription by promoters targeted by RNA polymerase II. (provided by RefSeq, Jul 2008)

GeneCards Summary for TAF7 Gene:
TAF7 (TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa) is a protein-coding gene. Diseases associated with TAF7 include gestational choriocarcinoma, and epidermodysplasia verruciformis. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TAF7L.

UniProtKB/Swiss-Prot: TAF7_HUMAN, Q15545
Function: Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric
protein complex that plays a central role in mediating promoter responses to various activators and repressors.
Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and
TFIID beta respectively)

Gene Wiki entry for TAF7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_029289.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the TAF7 gene promoter:
         AREB6   Sp1   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAF7 promoter sequence
   Search Chromatin IP Primers for TAF7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAF7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q31.3   HGNC cytogenetic band: 5q31

TAF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAF7 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M140678:  view genomic region     (about GC identifiers)

Start:
140,698,057 bp from pter      End:
140,700,351 bp from pter
Size:
2,295 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TAF7_HUMAN, Q15545 (See protein sequence)
Recommended Name: Transcription initiation factor TFIID subunit 7  
Size: 349 amino acids; 40259 Da
Subunit: TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts
with TAFII250, TAFII100, TAFII28, TAFII20, and TAFII18, but not with TAFII30 or TBP. Component of some MLL1/MLL
complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the
facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20,
PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10
Secondary accessions: B2RBV9 Q13036

Explore the universe of human proteins at neXtProt for TAF7: NX_Q15545

Explore proteomics data for TAF7 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys66, Lys141
  • Modification sites at PhosphoSitePlus

  • See TAF7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005633.2  
    ENSEMBL proteins: 
     ENSP00000312709  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR006751 TAFII55_prot_cons_reg

    Graphical View of Domain Structure for InterPro Entry Q15545

    ProtoNet protein and cluster: Q15545

    1 Blocks protein domain: IPB006751 TAFII55 protein conserved region

    UniProtKB/Swiss-Prot: TAF7_HUMAN, Q15545
    Domain: The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase, which methylates Lys-5
    in vitro (By similarity)
    Similarity: Belongs to the TAF7 family


    TAF7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAF7_HUMAN, Q15545
    Function: Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric
    protein complex that plays a central role in mediating promoter responses to various activators and repressors.
    Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and
    TFIID beta respectively)

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700contributes to sequence-specific DNA binding transcription factor activity IDA9603525
    GO:0003713transcription coactivator activity IDA7824954
    GO:0005515protein binding IPI7824954
    GO:0008134transcription factor binding IPI11005381
    GO:0035035histone acetyltransferase binding IPI11592977
         
    TAF7 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TAF7:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Taf7):
     embryogenesis  hematopoietic system  immune system  mortality/aging 

    TAF7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Taf7tm1.1Dss for TAF7

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TAF7
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TAF7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TAF7

    miRNA
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    miRTarBase miRNAs that target TAF7:
    hsa-mir-374b-5p (MIRT016037)

    Block miRNA regulation of human, mouse, rat TAF7 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate TAF7:
    hsa-miR-3685 hsa-miR-3140-3p hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmidTAF7 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TAF7

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    Sino Biological Human cDNA Clone for TAF7
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAF7

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TAF7_HUMAN, Q15545: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    golgi apparatus4
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005669transcription factor TFIID complex IDA14580349
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus IDA--

    TAF7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TAF7 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Assembly of RNA Polymerase-II Initiation Complex
    Assembly of RNA Polymerase-II Initiation Complex0.91
    Basal transcription factors0.50
    Transcription of mRNA0.91
    Crosstalk Between CARM1 and ESRs0.39
    Protein Acetylation and Deacetylation0.51
    2Formation of RNA Pol II elongation complex
    Eukaryotic Transcription Initiation0.59
    3Apoptotic Pathways in Synovial Fibroblasts
    Nuclear Receptor Activation by Vitamin-A0.57
    4GPCR Pathway
    Estrogen Pathway0.55
    5PEDF Induced Signaling
    Glucocorticoid Receptor Signaling0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TAF7 (see all 7)
        Nuclear Receptor Activation by Vitamin-A
    Protein Acetylation and Deacetylation
    Assembly of RNA Polymerase-II Initiation Complex
    Glucocorticoid Receptor Signaling
    Estrogen Pathway

    1 GeneGo (Thomson Reuters) Pathway for TAF7
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 BioSystems Pathway for TAF7
        Eukaryotic Transcription Initiation



    1 Kegg Pathway  (Kegg details for TAF7):
        Basal transcription factors


    TAF7 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TAF7
    Interactions:

        GeneGlobe Interaction Network for TAF7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TAF7 (Q155452, 3 ENSP000003127094) via UniProtKB, MINT, STRING, and/or I2D (see all 115)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAF9Q165943, ENSP000002178934I2D: score=3 STRING: ENSP00000370201 STRING: ENSP00000217893
    MAP1LC3BQ9GZQ82, 3, ENSP000002686074MINT-8259800 I2D: score=2 STRING: ENSP00000268607
    CPSF1Q105703, ENSP000003393534I2D: score=3 STRING: ENSP00000339353
    TAF1P216753, ENSP000002760724I2D: score=3 STRING: ENSP00000276072
    TAF15Q928043, ENSP000003095584I2D: score=3 STRING: ENSP00000309558
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA11592977
    GO:0000296spermine transport ISS--
    GO:0006352DNA-templated transcription, initiation IDA9603525
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0006366transcription from RNA polymerase II promoter IDA7824954

    TAF7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TAF7



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TAF7 gene: 
    NM_005642.2  

    Unigene Cluster for TAF7:

    TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
    Hs.438838  [show with all ESTs]
    Unigene Representative Sequence: NM_005642
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000313368(uc003ljg.3)
    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate TAF7:
    hsa-miR-3685 hsa-miR-3140-3p hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmidTAF7 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TAF7
      QuantiFast Probe-based Assays in human, mouse, rat TAF7

    Additional mRNA sequence: 

    AK314837.1 BC013397.2 BC022798.1 BC032737.1 U18062.1 X97999.1 

    17 DOTS entries:

    DT.87017021  DT.95316543  DT.91766955  DT.120808887  DT.120808871  DT.95136133  DT.100826252  DT.87017022 
    DT.120808882  DT.120808886  DT.120808893  DT.120808895  DT.418489  DT.91766950  DT.95316499  DT.95316545 
    DT.100826256 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TAF7 expression in normal human tissues (normalized intensities)      TAF7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGTGGAAA
    TAF7 Expression
    About this image


    TAF7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    TAF7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TAF7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.438838

    UniProtKB/Swiss-Prot: TAF7_HUMAN, Q15545
    Tissue specificity: Ubiquitous

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TAF7 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Taf71 , 5 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated more1, 5 88.82(n)1
    94.77(a)1
      18 (19.54 cM)5
    240741  NM_175770.41  NP_786964.11 
     376409025 
    chicken
    (Gallus gallus)
    Aves TAF71 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated more 78.38(n)
    87.69(a)
      422192  NM_001277886.1  NP_001264815.1 
    lizard
    (Anolis carolinensis)
    Reptilia TAF76
    TAF7 RNA polymerase II, TATA box binding protein (...
    74(a)
    1 ↔ 1
    GL343451.1(210232-221694)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.16842 Xenopus laevis transcribed sequence with moderate similarity more 78.11(n)    CA788309.1 
    zebrafish
    (Danio rerio)
    Actinopterygii taf72 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated more 75.54(n)   192342  AF506232.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Taf76
    TBP-associated factor 7
    26(a)
    1 → many
    3R(3733055-3735445)
    worm
    (Caenorhabditis elegans)
    Secernentea taf-7.26
    taf-7.16
    Protein TAF-7.1 (taf-7.1) mRNA, complete cds
    31(a)
    28(a)
    many ↔ many
    many ↔ many
    III(12671394-12673423) WBGene00006389
    X(11836197-11837476) WBGene00006388


    ENSEMBL Gene Tree for TAF7 (if available)
    TreeFam Gene Tree for TAF7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TAF7 gene
    TAF7L2  
    1 SIMAP similar gene for TAF7 using alignment to 1 protein entry:     TAF7_HUMAN:
    TAF7L

    TAF7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TAF7 (see all 93)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1154371831,2
    --140697661(+) CTCAAC/TTGAAG 1 -- ds50010--------
    rs1506460791,2
    C--140697672(+) AAAATG/TAGAAA 1 -- ds50010--------
    rs759609561,2
    C,F--140697833(+) TATCTA/GATGTT 1 -- ds50012Minor allele frequency- G:0.03NA 122
    rs802546661,2
    F--140697836(+) CTAATG/ATTTCC 1 -- ds50011Minor allele frequency- A:0.04WA 118
    rs790502221,2
    F--140697858(+) TAGATC/GAAATA 1 -- ds50011Minor allele frequency- G:0.06WA 118
    rs170971521,2
    C,F--140697870(+) AATTGG/AAATCT 1 -- ds50019Minor allele frequency- A:0.16NA CSA WA EA 506
    rs1435480981,2
    C--140698077(+) ATGCT-/TTTA  
            
    TTTAT
    1 -- ut310--------
    rs1408429821,2
    C--140698118(+) ATCTCA/TACATA 1 -- ut310--------
    rs24293491,2
    C--140698156(+) AACAAC/G/TTATTG 2 -- ut3113NA WA CSA EA 376
    rs77301,2
    C,F,O,A,H--140698165(-) TTTCCT/CATGCA 1 -- ut3124Minor allele frequency- C:0.27MN NA NS EA CSA WA 2835

    HapMap Linkage Disequilibrium report for TAF7 (140698057 - 140700351 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TAF7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv428127CNV Loss18775914
    dgv6351n71CNV Loss21882294
    dgv6352n71CNV Loss21882294
    dgv1858e1CNV Complex17122850
    dgv1857e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600573    OMIM disorders: --

    11 diseases for TAF7:    About MalaCards
    gestational choriocarcinoma    epidermodysplasia verruciformis    progeria    choriocarcinoma
    tonsillitis    hiv-1    thyroiditis    asthma
    malaria    cerebritis    endotheliitis

    2 diseases from the University of Copenhagen DISEASES database for TAF7:
    Epidermodysplasia verruciformis     Gestational choriocarcinoma

    TAF7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TAF7

    Export disorders for TAF7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TAF7 gene, integrated from 10 sources (see all 67):
    (articles sorted by number of sources associating them with TAF7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of an intrinsic human TFIID subunit that interacts with multiple transcriptional activators. (PubMed id 7824954)1, 2, 3 Chiang C.-M. and Roeder R.G. (Science 1995)
    2. Genome-wide association study of lung function decline in adults with and without asthma. (PubMed id 22424883)1, 4 Imboden M....Probst-Hensch N.M. (J. Allergy Clin. Immunol. 2012)
    3. Structural basis for the methylation site specificity of SET7/9. (PubMed id 16415881)1, 2 Couture J.-F.... Trievel R.C. (Nat. Struct. Mol. Biol. 2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PubMed id 15960975)1, 2 Dou Y.... Roeder R.G. (Cell 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. The intronless and TATA-less human TAFII55 gene contains a functional initiator and a downstream promoter element. (PubMed id 11340078)1, 2 Zhou T. and Chiang C.-M. (J. Biol. Chem. 2001)
    8. Multiple interactions between hTAFII55 and other TFIID subunits. Requirements for the formation of stable ternary complexes between hTAFII55 and the TATA-binding protein. (PubMed id 8702684)1, 2 Lavigne A.C.... Davidson I. (J. Biol. Chem. 1996)
    9. TAF7: a possible transcription initiation check-point regulator. (PubMed id 16407123)1, 9 Gegonne A....Singer D.S. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    10. TFIID component TAF7 functionally interacts with both TFIIH and P-TEFb. (PubMed id 18391197)1, 9 Gegonne A....Singer D.S. (Proc. Natl. Acad. Sci. U.S.A. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6879 HGNC: 11541 Ensembl:ENSG00000178913 euGenes: HUgn6879 ECgene: TAF7 Kegg: 6879
    H-InvDB: TAF7

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TAF7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TAF7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TAF7 gene:
    Search GeneIP for patents involving TAF7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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