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Aliases for TAF7 Gene

Aliases for TAF7 Gene

  • TATA-Box Binding Protein Associated Factor 7 2 3 5
  • TAF7 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 55kDa 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, F, 55kD 2 3
  • Transcription Initiation Factor TFIID 55 KDa Subunit 3 4
  • RNA Polymerase II TBP-Associated Factor Subunit F 3 4
  • TAF(II)55 3 4
  • TAFII-55 3 4
  • TAFII55 3 4
  • TAF2F 3 4
  • Transcription Initiation Factor TFIID, 55 KDa Subunit 3
  • TATA Box Binding Protein Associated Factor 7 3
  • Transcription Factor IID Subunit TAFII55 3
  • TBP-Associated Factor F 3

External Ids for TAF7 Gene

Previous HGNC Symbols for TAF7 Gene

  • TAF2F

Previous GeneCards Identifiers for TAF7 Gene

  • GC05M140514
  • GC05M141281
  • GC05M140681
  • GC05M140726
  • GC05M140678
  • GC05M135843

Summaries for TAF7 Gene

Entrez Gene Summary for TAF7 Gene

  • The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on chromosome 5. The protein encoded by this gene is a component of the TFIID protein complex, a complex which binds to the TATA box in class II promoters and recruits RNA polymerase II and other factors. This particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators. The protein is required for transcription by promoters targeted by RNA polymerase II. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAF7 Gene

TAF7 (TATA-Box Binding Protein Associated Factor 7) is a Protein Coding gene. Diseases associated with TAF7 include Gestational Choriocarcinoma. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Assembly of RNA Polymerase-II Initiation Complex. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription coactivator activity. An important paralog of this gene is TAF7L.

UniProtKB/Swiss-Prot for TAF7 Gene

  • Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively).

Gene Wiki entry for TAF7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF7 Gene

Genomics for TAF7 Gene

Regulatory Elements for TAF7 Gene

Enhancers for TAF7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TAF7 on UCSC Golden Path with GeneCards custom track

Promoters for TAF7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TAF7 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAF7 Gene

Chromosome:
5
Start:
141,260,225 bp from pter
End:
141,320,821 bp from pter
Size:
60,597 bases
Orientation:
Minus strand

Genomic View for TAF7 Gene

Genes around TAF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF7 Gene

Proteins for TAF7 Gene

  • Protein details for TAF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15545-TAF7_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 7
    Protein Accession:
    Q15545
    Secondary Accessions:
    • B2RBV9
    • Q13036

    Protein attributes for TAF7 Gene

    Size:
    349 amino acids
    Molecular mass:
    40259 Da
    Quaternary structure:
    • TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts with TAFII250, TAFII100, TAFII28, TAFII20, and TAFII18, but not with TAFII30 or TBP. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Binds to CIITA and TAF1 and inhibits their acetyltransferase activity, thereby repressing activated transcription and behaving as a repressor at these promoters.
    Miscellaneous:
    • Overexpression of TAF7 in HeLa cells inhibits cyclin D1 and cyclin A gene transcription and causes the cells to accumulate in early S phase. In contrast, depletion of TAF7 from TFIID complexes by siRNAs increases histone H3 acetylation at both cyclin promoters and stimulates cyclins CCND1 and CCNA gene transcription.

    Three dimensional structures from OCA and Proteopedia for TAF7 Gene

neXtProt entry for TAF7 Gene

Proteomics data for TAF7 Gene at MOPED

Post-translational modifications for TAF7 Gene

  • Phosphorylated by CIITA. Phosphorylation at Ser-264 by TAF1 in early G1 phase disrupts binding to TAF1.
  • Ubiquitination at Lys 66 and Lys 141
  • Modification sites at PhosphoSitePlus

Other Protein References for TAF7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAF7 Gene

Domains & Families for TAF7 Gene

Protein Domains for TAF7 Gene

Suggested Antigen Peptide Sequences for TAF7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15545

UniProtKB/Swiss-Prot:

TAF7_HUMAN :
  • The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase, which methylates Lys-5 in vitro.
  • Belongs to the TAF7 family.
Domain:
  • The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase, which methylates Lys-5 in vitro.
Family:
  • Belongs to the TAF7 family.
genes like me logo Genes that share domains with TAF7: view

No data available for Gene Families for TAF7 Gene

Function for TAF7 Gene

Molecular function for TAF7 Gene

UniProtKB/Swiss-Prot Function:
Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively).

Gene Ontology (GO) - Molecular Function for TAF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 7824954
GO:0035035 histone acetyltransferase binding IEA,IPI 11592977
genes like me logo Genes that share ontologies with TAF7: view
genes like me logo Genes that share phenotypes with TAF7: view

Animal Models for TAF7 Gene

MGI Knock Outs for TAF7:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAF7 Gene

Localization for TAF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAF7 Gene COMPARTMENTS Subcellular localization image for TAF7 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TAF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TAF7: view

Pathways & Interactions for TAF7 Gene

genes like me logo Genes that share pathways with TAF7: view

Gene Ontology (GO) - Biological Process for TAF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 11592977
GO:0000296 spermine transport ISS --
GO:0006367 transcription initiation from RNA polymerase II promoter IEA,IDA 9603525
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 12676957
genes like me logo Genes that share ontologies with TAF7: view

No data available for SIGNOR curated interactions for TAF7 Gene

Drugs & Compounds for TAF7 Gene

No Compound Related Data Available

Transcripts for TAF7 Gene

mRNA/cDNA for TAF7 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAF7 Gene

TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAF7 Gene

No ASD Table

Relevant External Links for TAF7 Gene

GeneLoc Exon Structure for
TAF7
ECgene alternative splicing isoforms for
TAF7

Expression for TAF7 Gene

mRNA expression in normal human tissues for TAF7 Gene

Protein differential expression in normal tissues from HIPED for TAF7 Gene

This gene is overexpressed in Retina (14.1), Fetal Brain (11.5), and Blymphocyte (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAF7 Gene



SOURCE GeneReport for Unigene cluster for TAF7 Gene Hs.438838

mRNA Expression by UniProt/SwissProt for TAF7 Gene

Q15545-TAF7_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with TAF7: view

Protein tissue co-expression partners for TAF7 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TAF7 Gene

Orthologs for TAF7 Gene

This gene was present in the common ancestor of animals.

Orthologs for TAF7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TAF7 35
  • 90.89 (n)
  • 97.6 (a)
TAF7 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAF7 35
  • 92.74 (n)
  • 98.85 (a)
TAF7 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taf7 35
  • 88.82 (n)
  • 94.77 (a)
Taf7 16
Taf7 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TAF7 35
  • 99.62 (n)
  • 100 (a)
TAF7 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Taf7 35
  • 89.44 (n)
  • 96.31 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 77 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TAF7 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAF7 35
  • 78.38 (n)
  • 87.69 (a)
TAF7 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAF7 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11144 35
taf7 35
  • 72.9 (n)
  • 76.95 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1684 35
zebrafish
(Danio rerio)
Actinopterygii taf7 35
  • 70.62 (n)
  • 72.95 (a)
taf7 35
taf7 36
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Taf7 36
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea taf-7.1 36
  • 28 (a)
ManyToMany
taf-7.2 36
  • 31 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for TAF7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAF7 Gene

ENSEMBL:
Gene Tree for TAF7 (if available)
TreeFam:
Gene Tree for TAF7 (if available)

Paralogs for TAF7 Gene

Paralogs for TAF7 Gene

(1) SIMAP similar genes for TAF7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TAF7: view

Variants for TAF7 Gene

Sequence variations from dbSNP and Humsavar for TAF7 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_005629 -
rs7730 -- 141,318,598(-) TTTCC(C/T)ATGCA utr-variant-3-prime
rs10310 -- 141,318,833(-) AATTT(A/G)TATTG utr-variant-3-prime
rs1056935 -- 141,320,660(-) TAATC(A/G)GTAGT utr-variant-5-prime
rs1802728 -- 141,319,580(-) AAGAA(A/T)TATAT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TAF7 Gene

Variant ID Type Subtype PubMed ID
dgv1857e1 CNV Complex 17122850
nsv428127 CNV Loss 18775914
dgv1858e1 CNV Complex 17122850
dgv6351n71 CNV Loss 21882294
dgv6352n71 CNV Loss 21882294

Variation tolerance for TAF7 Gene

Residual Variation Intolerance Score: 47.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.76% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TAF7 Gene

Disorders for TAF7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TAF7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
gestational choriocarcinoma
  • gestational chorionepithelioma
- elite association - COSMIC cancer census association via MalaCards
Search TAF7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TAF7

Genetic Association Database (GAD)
TAF7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAF7
genes like me logo Genes that share disorders with TAF7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAF7 Gene

Publications for TAF7 Gene

  1. Cloning of an intrinsic human TFIID subunit that interacts with multiple transcriptional activators. (PMID: 7824954) Chiang C.-M. … Roeder R.G. (Science 1995) 2 3 4 67
  2. TFIID component TAF7 functionally interacts with both TFIIH and P-TEFb. (PMID: 18391197) Gegonne A. … Singer D.S. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 23
  3. TAF7: a possible transcription initiation check-point regulator. (PMID: 16407123) Gegonne A. … Singer D.S. (Proc. Natl. Acad. Sci. U.S.A. 2006) 3 23
  4. TATA-binding protein-associated factor 7 regulates polyamine transport activity and polyamine analog-induced apoptosis. (PMID: 15078871) Fukuchi J. … Liao S. (J. Biol. Chem. 2004) 3 23
  5. MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex. (PMID: 25575120) Takahashi H. … Hatakeyama S. (Nat Commun 2015) 3

Products for TAF7 Gene

Sources for TAF7 Gene

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