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Aliases for TAF7 Gene

Aliases for TAF7 Gene

  • TATA-Box Binding Protein Associated Factor 7 2 3 5
  • TAF7 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 55kDa 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, F, 55kD 2 3
  • RNA Polymerase II TBP-Associated Factor Subunit F 3 4
  • TAF(II)55 3 4
  • TAFII-55 3 4
  • TAFII55 3 4
  • TAF2F 3 4
  • Transcription Initiation Factor TFIID, 55 KDa Subunit 3
  • Transcription Initiation Factor TFIID 55 KDa Subunit 4
  • Transcription Initiation Factor TFIID Subunit 7 3
  • Transcription Factor IID Subunit TAFII55 3
  • TBP-Associated Factor F 3

External Ids for TAF7 Gene

Previous HGNC Symbols for TAF7 Gene

  • TAF2F

Previous GeneCards Identifiers for TAF7 Gene

  • GC05M140514
  • GC05M141281
  • GC05M140681
  • GC05M140726
  • GC05M140678
  • GC05M135843

Summaries for TAF7 Gene

Entrez Gene Summary for TAF7 Gene

  • The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene clusters on chromosome 5. The protein encoded by this gene is a component of the TFIID protein complex, a complex which binds to the TATA box in class II promoters and recruits RNA polymerase II and other factors. This particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators. The protein is required for transcription by promoters targeted by RNA polymerase II. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAF7 Gene

TAF7 (TATA-Box Binding Protein Associated Factor 7) is a Protein Coding gene. Diseases associated with TAF7 include Gestational Choriocarcinoma. Among its related pathways are Formation of HIV elongation complex in the absence of HIV Tat and HIV Life Cycle. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription coactivator activity. An important paralog of this gene is TAF7L.

UniProtKB/Swiss-Prot for TAF7 Gene

  • Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively).

Gene Wiki entry for TAF7 Gene

Additional gene information for TAF7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF7 Gene

Genomics for TAF7 Gene

Regulatory Elements for TAF7 Gene

Enhancers for TAF7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H140344 1.6 FANTOM5 ENCODE dbSUPER 10.9 +973.7 973720 5 PKNOX1 SIN3A ZNF2 GLIS2 ZNF143 FOS ATF7 RUNX3 SP3 TSHZ1 SRA1 APBB3 HARS2 HARS IK PFDN1 TAF7 HBEGF CD14 PCDHA7
GH05H141563 1.6 Ensembl ENCODE dbSUPER 10.5 -243.6 -243592 1 FOXA2 PKNOX1 ARNT DMAP1 ZNF2 YY1 ZNF143 ZNF207 FOS SP3 HARS2 IK PCDHB8 PCDHB3 PCDHA6 PCDHB9 PCDHB7 ENSG00000272108 PCDHB15 PCDHGC3
GH05H142104 1.3 ENCODE dbSUPER 10.9 -786.6 -786583 6 PKNOX1 ARID4B SIN3A FEZF1 ZNF2 YY1 CBX5 JUNB REST ZNF592 NDFIP1 GNPDA1 TAF7 PCDHGA6 ENSG00000271871 PCDHB18P GC05P142103
GH05H141506 2 FANTOM5 Ensembl ENCODE dbSUPER 6 -195.7 -195658 20 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF207 PCDHGC4 DIAPH1 PCDHGB6 PCDHGA2 PCDHGC5 PCDHGA11 RN7SL68P PCDHGC3 PCDHGB7 PCDHGA10
GH05H141674 0.8 FANTOM5 ENCODE 5.2 -354.3 -354307 1 ZFHX2 POLR2A POU5F1 PRDM10 EGR2 PCDH1 RNF14 PCDH12 KIAA0141 PCDHGB6 TAF7 HDAC3 PCDHGC4 PCDHGA9 PCDHGB7
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAF7 on UCSC Golden Path with GeneCards custom track

Promoters for TAF7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000187846 21 1600 PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF143 ZNF207 SP3

Genomic Location for TAF7 Gene

Chromosome:
5
Start:
141,260,225 bp from pter
End:
141,320,821 bp from pter
Size:
60,597 bases
Orientation:
Minus strand

Genomic View for TAF7 Gene

Genes around TAF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF7 Gene

Proteins for TAF7 Gene

  • Protein details for TAF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15545-TAF7_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 7
    Protein Accession:
    Q15545
    Secondary Accessions:
    • B2RBV9
    • Q13036

    Protein attributes for TAF7 Gene

    Size:
    349 amino acids
    Molecular mass:
    40259 Da
    Quaternary structure:
    • TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs) (PubMed:27007846, PubMed:10438527). Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:27007846). Interacts with TAF1; the interaction is direct (PubMed:25412659). Interacts with TAFII250, TAFII100, TAFII28, TAFII20, and TAFII18, but not with TAFII30 or TBP (PubMed:8702684, PubMed:10438527). Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10 (PubMed:15960975). Binds to CIITA and TAF1 and inhibits their acetyltransferase activity, thereby repressing activated transcription and behaving as a repressor at these promoters.
    Miscellaneous:
    • Overexpression of TAF7 in HeLa cells inhibits cyclin D1 and cyclin A gene transcription and causes the cells to accumulate in early S phase. In contrast, depletion of TAF7 from TFIID complexes by siRNAs increases histone H3 acetylation at both cyclin promoters and stimulates cyclins CCND1 and CCNA gene transcription.

    Three dimensional structures from OCA and Proteopedia for TAF7 Gene

neXtProt entry for TAF7 Gene

Post-translational modifications for TAF7 Gene

  • Phosphorylated by CIITA. Phosphorylation at Ser-264 by TAF1 in early G1 phase disrupts binding to TAF1.
  • Ubiquitination at Lys66 and posLast=141141
  • Modification sites at PhosphoSitePlus

Other Protein References for TAF7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAF7 Gene

Domains & Families for TAF7 Gene

Gene Families for TAF7 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TAF7 Gene

Suggested Antigen Peptide Sequences for TAF7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15545

UniProtKB/Swiss-Prot:

TAF7_HUMAN :
  • The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase, which methylates Lys-5 in vitro.
  • Belongs to the TAF7 family.
Domain:
  • The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase, which methylates Lys-5 in vitro.
Family:
  • Belongs to the TAF7 family.
genes like me logo Genes that share domains with TAF7: view

Function for TAF7 Gene

Molecular function for TAF7 Gene

UniProtKB/Swiss-Prot Function:
Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively).

Phenotypes From GWAS Catalog for TAF7 Gene

Gene Ontology (GO) - Molecular Function for TAF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 contributes_to transcription factor activity, sequence-specific DNA binding IDA 9603525
GO:0003713 transcription coactivator activity IDA 7824954
GO:0005515 protein binding IPI 7824954
GO:0008134 transcription factor binding IPI 7824954
GO:0035035 histone acetyltransferase binding IPI,IEA 11592977
genes like me logo Genes that share ontologies with TAF7: view
genes like me logo Genes that share phenotypes with TAF7: view

Animal Models for TAF7 Gene

MGI Knock Outs for TAF7:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TAF7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAF7 Gene

Localization for TAF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAF7 gene
Compartment Confidence
nucleus 5
golgi apparatus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TAF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005667 transcription factor complex IPI 25412659
GO:0005669 transcription factor TFIID complex IEA,IDA 7824954
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TAF7: view

Pathways & Interactions for TAF7 Gene

genes like me logo Genes that share pathways with TAF7: view

Gene Ontology (GO) - Biological Process for TAF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 11592977
GO:0000296 spermine transport ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006352 DNA-templated transcription, initiation IDA 9603525
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TAF7: view

No data available for SIGNOR curated interactions for TAF7 Gene

Drugs & Compounds for TAF7 Gene

No Compound Related Data Available

Transcripts for TAF7 Gene

mRNA/cDNA for TAF7 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAF7 Gene

TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TAF7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TAF7 Gene

No ASD Table

Relevant External Links for TAF7 Gene

GeneLoc Exon Structure for
TAF7
ECgene alternative splicing isoforms for
TAF7

Expression for TAF7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAF7 Gene

Protein differential expression in normal tissues from HIPED for TAF7 Gene

This gene is overexpressed in Retina (14.1), Fetal Brain (11.5), and Blymphocyte (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TAF7 Gene



Protein tissue co-expression partners for TAF7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TAF7 Gene:

TAF7

SOURCE GeneReport for Unigene cluster for TAF7 Gene:

Hs.438838

mRNA Expression by UniProt/SwissProt for TAF7 Gene:

Q15545-TAF7_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for TAF7 Gene

  • Nervous system(4.9)
  • Skin(4.6)
  • Liver(4.5)
  • Kidney(2.4)
  • Heart(2.3)
  • Muscle(2.3)
  • Spleen(2.3)
genes like me logo Genes that share expression patterns with TAF7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAF7 Gene

Orthologs for TAF7 Gene

This gene was present in the common ancestor of animals.

Orthologs for TAF7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF7 33 34
  • 99.62 (n)
dog
(Canis familiaris)
Mammalia TAF7 33 34
  • 92.74 (n)
cow
(Bos Taurus)
Mammalia TAF7 33 34
  • 90.89 (n)
rat
(Rattus norvegicus)
Mammalia Taf7 33
  • 89.44 (n)
mouse
(Mus musculus)
Mammalia Taf7 33 16 34
  • 88.82 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 84 (a)
OneToMany
-- 34
  • 80 (a)
OneToMany
-- 34
  • 77 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TAF7 34
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAF7 33 34
  • 78.38 (n)
lizard
(Anolis carolinensis)
Reptilia TAF7 34
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia taf7 33
  • 72.9 (n)
Str.11144 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.1684 33
zebrafish
(Danio rerio)
Actinopterygii taf7 33 33 34
  • 70.62 (n)
fruit fly
(Drosophila melanogaster)
Insecta Taf7 34
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea taf-7.2 34
  • 31 (a)
ManyToMany
taf-7.1 34
  • 28 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
OneToMany
Species where no ortholog for TAF7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAF7 Gene

ENSEMBL:
Gene Tree for TAF7 (if available)
TreeFam:
Gene Tree for TAF7 (if available)

Paralogs for TAF7 Gene

Paralogs for TAF7 Gene

(1) SIMAP similar genes for TAF7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TAF7: view

Variants for TAF7 Gene

Sequence variations from dbSNP and Humsavar for TAF7 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000278832 -- 141,318,805(+) CTTCT(C/T)ATAGG utr-variant-3-prime
rs1001002787 -- 141,322,489(+) GATAA(C/T)GGTAA upstream-variant-2KB
rs1001638442 -- 141,318,207(+) TTTAA(A/G)AAAGG downstream-variant-500B
rs1002930624 -- 141,318,566(+) AAGCT(C/G)CTTTG utr-variant-3-prime
rs1003295342 -- 141,318,293(+) GATCA(A/G)ATAGA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TAF7 Gene

Variant ID Type Subtype PubMed ID
esv2759382 CNV gain 17122850
nsv428127 CNV loss 18775914
nsv477099 CNV novel sequence insertion 20440878

Variation tolerance for TAF7 Gene

Residual Variation Intolerance Score: 47.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.35; 7.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAF7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAF7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF7 Gene

Disorders for TAF7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TAF7 Gene - From: DISEASES

Disorder Aliases PubMed IDs
gestational choriocarcinoma
  • gestational chorionepithelioma
- elite association - COSMIC cancer census association via MalaCards
Search TAF7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TAF7

Genetic Association Database (GAD)
TAF7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAF7
genes like me logo Genes that share disorders with TAF7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAF7 Gene

Publications for TAF7 Gene

  1. Cloning of an intrinsic human TFIID subunit that interacts with multiple transcriptional activators. (PMID: 7824954) Chiang CM … Roeder RG (Science (New York, N.Y.) 1995) 2 3 4 60
  2. Structure of promoter-bound TFIID and model of human pre-initiation complex assembly. (PMID: 27007846) Louder RK … Nogales E (Nature 2016) 3 4 60
  3. Crystal structure of a TAF1-TAF7 complex in human transcription factor IID reveals a promoter binding module. (PMID: 25412659) Wang H … Zheng N (Cell research 2014) 3 4 60
  4. Phosphorylation-dependent regulation of cyclin D1 and cyclin A gene transcription by TFIID subunits TAF1 and TAF7. (PMID: 22711989) Kloet SL … Wang EH (Molecular and cellular biology 2012) 3 4 60
  5. Genome-wide association study of lung function decline in adults with and without asthma. (PMID: 22424883) Imboden M … Probst-Hensch NM (The Journal of allergy and clinical immunology 2012) 3 45 60

Products for TAF7 Gene

Sources for TAF7 Gene

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