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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAF7 Gene

protein-coding   GIFtS: 61
GCID: GC05M140678

TAF7 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated...

(Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase...)
(Previous symbol: TAF2F)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TAF7 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated
Factor, 55kDa1 2
     TAFII-552 3
TAF2F1 2 3 5     RNA Polymerase II TBP-Associated Factor Subunit F2 3
TAFII552 3 5     TBP-Associated Factor F2
TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, F,
55kD1 2
     Transcription Factor IID Subunit TAFII552
Transcription Initiation Factor TFIID 55 KDa Subunit2 3     Transcription Initiation Factor TFIID Subunit 72
TAF(II)552 3     Transcription Initiation Factor TFIID, 55 KDa Subunit2

External Ids:    HGNC: 115411   Entrez Gene: 68792   Ensembl: ENSG000001789137   OMIM: 6005735   UniProtKB: Q155453   

Export aliases for TAF7 gene to outside databases

Previous GC identifers: GC05M140514 GC05M141281 GC05M140681 GC05M140726 GC05M135843


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TAF7 Gene:
The intronless gene for this transcription coactivator is located between the protocadherin beta and gamma gene
clusters on chromosome 5. The protein encoded by this gene is a component of the TFIID protein complex, a complex
which binds to the TATA box in class II promoters and recruits RNA polymerase II and other factors. This
particular subunit interacts with the largest TFIID subunit, as well as multiple transcription activators. The
protein is required for transcription by promoters targeted by RNA polymerase II. (provided by RefSeq, Jul 2008)

GeneCards Summary for TAF7 Gene: 
TAF7 (TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa) is a protein-coding gene. Diseases associated with TAF7 include gestational choriocarcinoma, and epidermodysplasia verruciformis, and among its related super-pathways are Assembly of RNA Polymerase-II Initiation Complex and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TAF7L.

UniProtKB/Swiss-Prot: TAF7_HUMAN, Q15545
Function: Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric
protein complex that plays a central role in mediating promoter responses to various activators and repressors.
Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and
TFIID beta respectively)

Gene Wiki entry for TAF7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_029289.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAF7 gene promoter:
         AREB6   Sp1   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAF7 promoter sequence
   Search SABiosciences Chromatin IP Primers for TAF7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAF7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q31.3   HGNC cytogenetic band: 5q31

TAF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAF7 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M140678:  view genomic region     (about GC identifiers)

Start:
140,698,057 bp from pter      End:
140,700,351 bp from pter
Size:
2,295 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TAF7_HUMAN, Q15545 (See protein sequence)
Recommended Name: Transcription initiation factor TFIID subunit 7  
Size: 349 amino acids; 40259 Da
Subunit: TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts
with TAFII250, TAFII100, TAFII28, TAFII20, and TAFII18, but not with TAFII30 or TBP. Component of some MLL1/MLL
complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the
facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20,
PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10
Subcellular location: Nucleus
Secondary accessions: B2RBV9 Q13036

Explore the universe of human proteins at neXtProt for TAF7: NX_Q15545

Explore proteomics data for TAF7 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15545

  • TAF7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TAF7 Protein Expression
    REFSEQ proteins: NP_005633.2  
    ENSEMBL proteins: 
     ENSP00000312709  

    Human Recombinant Protein Products for TAF7: 
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    Cloud-Clone Corp. Proteins for TAF7 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005669transcription factor TFIID complex IDA14580349
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm ----
    GO:0005794Golgi apparatus IDA--

    TAF7 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR006751 TAFII55_prot_cons_reg

    Graphical View of Domain Structure for InterPro Entry Q15545

    ProtoNet protein and cluster: Q15545

    1 Blocks protein domain: IPB006751 TAFII55 protein conserved region

    UniProtKB/Swiss-Prot: TAF7_HUMAN, Q15545
    Domain: The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase, which methylates Lys-5
    in vitro (By similarity)
    Similarity: Belongs to the TAF7 family


    TAF7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAF7_HUMAN, Q15545
    Function: Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric
    protein complex that plays a central role in mediating promoter responses to various activators and repressors.
    Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and
    TFIID beta respectively)

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700contributes to sequence-specific DNA binding transcription factor activity IDA9603525
    GO:0003713transcription coactivator activity IDA7824954
    GO:0005515protein binding IPI7824954
    GO:0008134transcription factor binding IPI11005381
    GO:0035035histone acetyltransferase binding IPI11592977
         
    TAF7 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TAF7:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Taf7):
     cellular  embryogenesis  hematopoietic system  immune system  mortality/aging 

    TAF7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Taf7tm1.1Dss for TAF7

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TAF7 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TAF7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TAF7 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TAF7 

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate TAF7:
    hsa-miR-3685 hsa-miR-3140-3p hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmidTAF7 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF7


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TAF7 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Assembly of RNA Polymerase-II Initiation Complex
    Assembly of RNA Polymerase-II Initiation Complex0.91
    Basal transcription factors0.50
    Transcription of mRNA0.91
    Crosstalk Between CARM1 and ESRs0.39
    Protein Acetylation and Deacetylation0.51
    2Formation of RNA Pol II elongation complex
    Eukaryotic Transcription Initiation0.60
    3Apoptotic Pathways in Synovial Fibroblasts
    Nuclear Receptor Activation by Vitamin-A0.57
    4GPCR Pathway
    Estrogen Pathway0.55
    5Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes1.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for TAF7
        Histone modification
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TAF7 (see all 7)
        Nuclear Receptor Activation by Vitamin-A
    Protein Acetylation and Deacetylation
    Assembly of RNA Polymerase-II Initiation Complex
    Glucocorticoid Receptor Signaling
    Estrogen Pathway

    1 GeneGo (Thomson Reuters) Pathway for TAF7
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 BioSystems Pathway for TAF7
        Eukaryotic Transcription Initiation


    1         Kegg Pathway  (Kegg details for TAF7):
        Basal transcription factors


    TAF7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TAF7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/87 Interacting proteins for TAF7 (Q155452, 3 ENSP000003127094) via UniProtKB, MINT, STRING, and/or I2D (see all 87)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAF9Q165943, ENSP000002178934I2D: score=3 STRING: ENSP00000370201 STRING: ENSP00000217893
    MAP1LC3BQ9GZQ82, 3, ENSP000002686074MINT-8259800 I2D: score=2 STRING: ENSP00000268607
    AK6Q165943I2D: score=3 
    CPSF1Q105703, ENSP000003393534I2D: score=3 STRING: ENSP00000339353
    TAF1P216753, ENSP000002760724I2D: score=3 STRING: ENSP00000276072
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA11592977
    GO:0000296spermine transport ISS--
    GO:0006352DNA-dependent transcription, initiation IDA9603525
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0006366transcription from RNA polymerase II promoter IDA7824954

    TAF7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TAF7

    Search CenterWatch for drugs/clinical trials and news about TAF7

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TAF7 gene: 
    NM_005642.2  

    Unigene Cluster for TAF7:

    TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
    Hs.438838  [show with all ESTs]
    Unigene Representative Sequence: NM_005642
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000313368(uc003ljg.3)
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidTAF7 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK314837.1 BC013397.2 BC022798.1 BC032737.1 U18062.1 X97999.1 

    17 DOTS entries:

    DT.87017021  DT.95316543  DT.91766955  DT.120808887  DT.120808871  DT.95136133  DT.100826252  DT.87017022 
    DT.120808882  DT.120808886  DT.120808893  DT.120808895  DT.418489  DT.91766950  DT.95316499  DT.95316545 
    DT.100826256 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TAF7 expression in normal human tissues (normalized intensities)      TAF7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAGTGGAAA
    TAF7 Expression
    About this image


    TAF7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/29 selected tissues (see all 29) fully expand
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Uterus (Reproductive System)    fully expand to see all 4 entries
             uterus, post-menopause ; glandular cells   
     
     Epithelium
             oral mucosa ; squamous epithelial cells   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex

    See TAF7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TAF7

    SOURCE GeneReport for Unigene cluster: Hs.438838

    UniProtKB/Swiss-Prot: TAF7_HUMAN, Q15545
    Tissue specificity: Ubiquitous

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TAF7 gene from 8/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Taf71 , 5 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated more1, 5 88.66(n)1
    95.01(a)1
      18 (19.54 cM)5
    240741  NM_175770.41  NP_786964.11 
     376409025 
    chicken
    (Gallus gallus)
    Aves TAF71 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated more 78.03(n)
    86.82(a)
      422192  XM_420187.2  XP_420187.1 
    lizard
    (Anolis carolinensis)
    Reptilia TAF76
    TAF7 RNA polymerase II, TATA box binding protein (...
    73(a)
    1 ↔ 1
    GL343451.1(210232-221694)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.16842 Xenopus laevis transcribed sequence with moderate similarity more 78.11(n)    CA788309.1 
    zebrafish
    (Danio rerio)
    Actinopterygii taf72 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated more 75.54(n)   192342  AF506232.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Taf71 TBP-associated factor 7 54.57(n)
    50.44(a)
      40934  NM_141491.2  NP_649748.1 
    worm
    (Caenorhabditis elegans)
    Secernentea taf-7.21 Protein TAF-7.2 50.89(n)
    41.06(a)
      176686  NM_067246.2  NP_499647.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TAF71 Taf7p 46.19(n)
    28.21(a)
      855267   NP_013954.1 


    ENSEMBL Gene Tree for TAF7 (if available)
    TreeFam Gene Tree for TAF7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TAF7 gene
    TAF7L2  
    1 SIMAP similar gene for TAF7 using alignment to 1 protein entry:     TAF7_HUMAN:
    TAF7L

    TAF7 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/93 SNPs in TAF7 are shown (see all 93)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0056294
    ----see VAR_0056292 S R mis40--------
    rs1154371831,2
    --140697661(+) CTCAAC/TTGAAG 1 -- ds50010--------
    rs1506460791,2
    C--140697672(+) AAAATG/TAGAAA 1 -- ds50010--------
    rs759609561,2
    C,F--140697833(+) TATCTA/GATGTT 1 -- ds50012Minor allele frequency- G:0.03NA 122
    rs802546661,2
    F--140697836(+) CTAATG/ATTTCC 1 -- ds50011Minor allele frequency- A:0.04WA 118
    rs790502221,2
    F--140697858(+) TAGATC/GAAATA 1 -- ds50011Minor allele frequency- G:0.06WA 118
    rs170971521,2
    C,F--140697870(+) AATTGG/AAATCT 1 -- ds50019Minor allele frequency- A:0.16NA CSA WA EA 506
    rs1435480981,2
    C--140698077(+) ATGCT-/TTTA  
            
    TTTAT
    1 -- ut310--------
    rs1408429821,2
    C--140698118(+) ATCTCA/TACATA 1 -- ut310--------
    rs24293491,2
    C--140698156(+) AACAAC/G/TTATTG 2 -- ut3113NA WA CSA EA 376

    HapMap Linkage Disequilibrium report for TAF7 (140698057 - 140700351 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TAF7:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv428127CNV Loss18775914
    dgv6351n71CNV Loss21882294
    dgv6352n71CNV Loss21882294
    dgv1858e1CNV Complex17122850
    dgv1857e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600573    OMIM disorders: --

    5 diseases for TAF7:    About MalaCards
    gestational choriocarcinoma    epidermodysplasia verruciformis    progeria    choriocarcinoma
    thyroiditis

    2 diseases from the University of Copenhagen DISEASES database for TAF7:
    Epidermodysplasia verruciformis     Gestational choriocarcinoma

    TAF7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TAF7

    Export disorders for TAF7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TAF7 gene, integrated from 9 sources (see all 66):
    (articles sorted by number of sources associating them with TAF7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of an intrinsic human TFIID subunit that interacts with multiple transcriptional activators. (PubMed id 7824954)1, 2, 3 Chiang C.-M. and Roeder R.G. (1995)
    2. Genome-wide association study of lung function decline in adults with and without asthma. (PubMed id 22424883)1, 4 Imboden M....Probst-Hensch N.M. (2012)
    3. Structural basis for the methylation site specificity of SET7/9. (PubMed id 16415881)1, 2 Couture J.-F.... Trievel R.C. (2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PubMed id 15960975)1, 2 Dou Y.... Roeder R.G. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The intronless and TATA-less human TAFII55 gene contains a functional initiator and a downstream promoter element. (PubMed id 11340078)1, 2 Zhou T. and Chiang C.-M. (2001)
    8. Multiple interactions between hTAFII55 and other TFIID subunits. Requirements for the formation of stable ternary complexes between hTAFII55 and the TATA-binding protein. (PubMed id 8702684)1, 2 Lavigne A.C.... Davidson I. (1996)
    9. TAF7: a possible transcription initiation check-point regulator. (PubMed id 16407123)1, 9 Gegonne A....Singer D.S. (2006)
    10. TFIID component TAF7 functionally interacts with both TFIIH and P-TEFb. (PubMed id 18391197)1, 9 Gegonne A....Singer D.S. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6879 HGNC: 11541 Ensembl:ENSG00000178913 euGenes: HUgn6879 ECgene: TAF7 Kegg: 6879
    H-InvDB: TAF7

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TAF7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TAF7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TAF7 gene:
    Search GeneIP for patents involving TAF7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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