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Aliases for TAF6L Gene

Aliases for TAF6L Gene

  • TATA-Box Binding Protein Associated Factor 6 Like 2 3 5
  • TAF6-Like RNA Polymerase II, P300/CBP-Associated Factor (PCAF)-Associated Factor, 65kDa 2 3
  • PCAF-Associated Factor 65-Alpha 3 4
  • PAF65-Alpha 3 4
  • PAF65A 3 4
  • TAF6-Like RNA Polymerase II, P300/CBP-Associated Factor (PCAF)-Associated Factor, 65 KD 2
  • P300/CBP-Associated Factor (PCAF)-Associated Factor 65 3
  • TATA Box Binding Protein Associated Factor 6 Like 3
  • PCAF-Associated Factor 65 Alpha 3

External Ids for TAF6L Gene

Previous GeneCards Identifiers for TAF6L Gene

  • GC11P065051
  • GC11P064114
  • GC11P062790
  • GC11P062314
  • GC11P062295
  • GC11P062538
  • GC11P058868

Summaries for TAF6L Gene

Entrez Gene Summary for TAF6L Gene

  • Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAF6L Gene

TAF6L (TATA-Box Binding Protein Associated Factor 6 Like) is a Protein Coding gene. Among its related pathways are Chromatin organization and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include protein heterodimerization activity and histone acetyltransferase activity. An important paralog of this gene is TAF6.

UniProtKB/Swiss-Prot for TAF6L Gene

  • Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex.

Gene Wiki entry for TAF6L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF6L Gene

Genomics for TAF6L Gene

Regulatory Elements for TAF6L Gene

Enhancers for TAF6L Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TAF6L on UCSC Golden Path with GeneCards custom track

Promoters for TAF6L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TAF6L on UCSC Golden Path with GeneCards custom track

Genomic Location for TAF6L Gene

Chromosome:
11
Start:
62,771,303 bp from pter
End:
62,787,342 bp from pter
Size:
16,040 bases
Orientation:
Plus strand

Genomic View for TAF6L Gene

Genes around TAF6L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF6L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF6L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF6L Gene

Proteins for TAF6L Gene

  • Protein details for TAF6L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6J9-TAF6L_HUMAN
    Recommended name:
    TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
    Protein Accession:
    Q9Y6J9
    Secondary Accessions:
    • B2RAT0
    • Q96HA6

    Protein attributes for TAF6L Gene

    Size:
    622 amino acids
    Molecular mass:
    67814 Da
    Quaternary structure:
    • The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.

neXtProt entry for TAF6L Gene

Proteomics data for TAF6L Gene at MOPED

Post-translational modifications for TAF6L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAF6L Gene

No data available for DME Specific Peptides for TAF6L Gene

Domains & Families for TAF6L Gene

Gene Families for TAF6L Gene

Protein Domains for TAF6L Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y6J9

UniProtKB/Swiss-Prot:

TAF6L_HUMAN :
  • Belongs to the TAF6 family.
Family:
  • Belongs to the TAF6 family.
genes like me logo Genes that share domains with TAF6L: view

Function for TAF6L Gene

Molecular function for TAF6L Gene

UniProtKB/Swiss-Prot Function:
Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex.
genes like me logo Genes that share phenotypes with TAF6L: view

Animal Model Products

CRISPR Products

miRNA for TAF6L Gene

miRTarBase miRNAs that target TAF6L

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAF6L Gene

Localization for TAF6L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF6L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAF6L Gene COMPARTMENTS Subcellular localization image for TAF6L gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for TAF6L Gene

Pathways & Interactions for TAF6L Gene

genes like me logo Genes that share pathways with TAF6L: view

Gene Ontology (GO) - Biological Process for TAF6L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0043966 histone H3 acetylation IDA 11564863
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with TAF6L: view

No data available for SIGNOR curated interactions for TAF6L Gene

Drugs & Compounds for TAF6L Gene

No Compound Related Data Available

Transcripts for TAF6L Gene

Unigene Clusters for TAF6L Gene

TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAF6L Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10
SP1: - - -
SP2: -
SP3: -
SP4:
SP5:

Relevant External Links for TAF6L Gene

GeneLoc Exon Structure for
TAF6L
ECgene alternative splicing isoforms for
TAF6L

Expression for TAF6L Gene

mRNA expression in normal human tissues for TAF6L Gene

Protein differential expression in normal tissues from HIPED for TAF6L Gene

This gene is overexpressed in Plasma (15.7), Liver, secretome (15.5), Pancreas (12.5), and CD8 Tcells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAF6L Gene



SOURCE GeneReport for Unigene cluster for TAF6L Gene Hs.714400

genes like me logo Genes that share expression patterns with TAF6L: view

Protein tissue co-expression partners for TAF6L Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TAF6L Gene

Orthologs for TAF6L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAF6L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TAF6L 35
  • 88.75 (n)
  • 93.86 (a)
TAF6L 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAF6L 35
  • 88.51 (n)
  • 94.66 (a)
TAF6L 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taf6l 35
  • 85.66 (n)
  • 93.51 (a)
Taf6l 16
Taf6l 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TAF6L 35
  • 99.62 (n)
  • 99.84 (a)
TAF6L 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Taf6l 35
  • 85.44 (n)
  • 93.34 (a)
oppossum
(Monodelphis domestica)
Mammalia TAF6L 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAF6L 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAF6L 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11073 35
taf6l 35
  • 62.52 (n)
  • 66.9 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14337 35
zebrafish
(Danio rerio)
Actinopterygii taf6l 35
  • 64.94 (n)
  • 68.45 (a)
wufa05b10 35
taf6l 36
  • 63 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mia 36
  • 17 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea taf-6.1 36
  • 13 (a)
OneToMany
taf-6.2 36
  • 11 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF6 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToOne
Species with no ortholog for TAF6L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAF6L Gene

ENSEMBL:
Gene Tree for TAF6L (if available)
TreeFam:
Gene Tree for TAF6L (if available)

Paralogs for TAF6L Gene

Paralogs for TAF6L Gene

(1) SIMAP similar genes for TAF6L Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TAF6L: view

Variants for TAF6L Gene

Sequence variations from dbSNP and Humsavar for TAF6L Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs542242 -- 62,775,708(+) GTTGG(A/G)TCACA intron-variant
rs544315 -- 62,773,832(-) tttca(C/G)ttcaa intron-variant
rs545204 -- 62,773,741(-) GCTGG(A/G)CCCAG intron-variant
rs545371 -- 62,774,257(+) atttt(A/T)agtag intron-variant
rs566110 -- 62,774,115(+) tctgt(C/T)gccca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAF6L Gene

Variant ID Type Subtype PubMed ID
nsv897623 CNV Loss 21882294
nsv483055 CNV Loss 15286789
nsv508636 CNV Loss 20534489
nsv509416 CNV Insertion 20534489
nsv897624 CNV Loss 21882294

Variation tolerance for TAF6L Gene

Residual Variation Intolerance Score: 17.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.76; 33.39% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TAF6L Gene

Disorders for TAF6L Gene

Relevant External Links for TAF6L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAF6L

No disorders were found for TAF6L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAF6L Gene

Publications for TAF6L Gene

  1. Histone-like TAFs within the PCAF histone acetylase complex. (PMID: 9674425) Ogryzko V.V. … Nakatani Y. (Cell 1998) 2 3 4 67
  2. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for TAF6L Gene

Sources for TAF6L Gene

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