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Aliases for TAF6L Gene

Aliases for TAF6L Gene

  • TAF6-Like RNA Polymerase II, P300/CBP-Associated Factor (PCAF)-Associated Factor, 65kDa 2 3
  • PCAF-Associated Factor 65-Alpha 3 4
  • PAF65-Alpha 3 4
  • PAF65A 3 4
  • TAF6-Like RNA Polymerase II P300/CBP-Associated Factor-Associated Factor 65 KDa Subunit 6L 3
  • TAF6-Like RNA Polymerase II, P300/CBP-Associated Factor (PCAF)-Associated Factor, 65 KD 2
  • P300/CBP-Associated Factor (PCAF)-Associated Factor 65 3
  • PCAF-Associated Factor 65 Alpha 3

External Ids for TAF6L Gene

Summaries for TAF6L Gene

Entrez Gene Summary for TAF6L Gene

  • Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAF6L Gene

TAF6L (TAF6-Like RNA Polymerase II, P300/CBP-Associated Factor (PCAF)-Associated Factor, 65kDa) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include protein heterodimerization activity and histone acetyltransferase activity. An important paralog of this gene is TAF6.

UniProtKB/Swiss-Prot for TAF6L Gene

  • Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex

Gene Wiki entry for TAF6L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF6L Gene

Genomics for TAF6L Gene

Genomic Location for TAF6L Gene

Start:
62,771,303 bp from pter
End:
62,787,342 bp from pter
Size:
16,040 bases
Orientation:
Plus strand

Genomic View for TAF6L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAF6L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF6L Gene

Regulatory Elements for TAF6L Gene

Proteins for TAF6L Gene

  • Protein details for TAF6L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6J9-TAF6L_HUMAN
    Recommended name:
    TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
    Protein Accession:
    Q9Y6J9
    Secondary Accessions:
    • B2RAT0
    • Q96HA6

    Protein attributes for TAF6L Gene

    Size:
    622 amino acids
    Molecular mass:
    67814 Da
    Quaternary structure:
    • The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.

neXtProt entry for TAF6L Gene

Proteomics data for TAF6L Gene at MOPED

Post-translational modifications for TAF6L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAF6L Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TAF6L Gene

Domains for TAF6L Gene

Protein Domains for TAF6L Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y6J9

UniProtKB/Swiss-Prot:

TAF6L_HUMAN
Family:
  • Belongs to the TAF6 family.:
    • Q9Y6J9
genes like me logo Genes that share domains with TAF6L: view

No data available for Gene Families for TAF6L Gene

Function for TAF6L Gene

Molecular function for TAF6L Gene

UniProtKB/Swiss-Prot Function: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex

Gene Ontology (GO) - Molecular Function for TAF6L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 9674425
GO:0003713 transcription coactivator activity IDA 11564863
GO:0004402 contributes_to histone acetyltransferase activity IDA 11564863
GO:0005515 protein binding IPI 16713569
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with TAF6L: view
genes like me logo Genes that share phenotypes with TAF6L: view

miRNA for TAF6L Gene

miRTarBase miRNAs that target TAF6L

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TAF6L Gene

Localization for TAF6L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF6L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAF6L Gene COMPARTMENTS Subcellular localization image for TAF6L gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TAF6L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex TAS 9674425
GO:0005634 nucleus --
GO:0030914 STAGA complex IDA 11564863
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with TAF6L: view

Pathways for TAF6L Gene

genes like me logo Genes that share pathways with TAF6L: view

Gene Ontology (GO) - Biological Process for TAF6L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006338 chromatin remodeling TAS 9674425
GO:0006352 DNA-templated transcription, initiation IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9674425
GO:0043966 histone H3 acetylation IDA 11564863
genes like me logo Genes that share ontologies with TAF6L: view

Transcripts for TAF6L Gene

Unigene Clusters for TAF6L Gene

TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAF6L Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10
SP1: - - -
SP2: -
SP3: -
SP4:
SP5:

Relevant External Links for TAF6L Gene

GeneLoc Exon Structure for
TAF6L
ECgene alternative splicing isoforms for
TAF6L

Expression for TAF6L Gene

mRNA expression in normal human tissues for TAF6L Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAF6L Gene

SOURCE GeneReport for Unigene cluster for TAF6L Gene Hs.714400

genes like me logo Genes that share expressions with TAF6L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TAF6L Gene

Orthologs for TAF6L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAF6L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF6L 35
  • 99.62 (n)
  • 99.84 (a)
TAF6L 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAF6L 35
  • 88.75 (n)
  • 93.86 (a)
TAF6L 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAF6L 35
  • 88.51 (n)
  • 94.66 (a)
TAF6L 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taf6l 35
  • 85.66 (n)
  • 93.51 (a)
Taf6l 16
Taf6l 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAF6L 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Taf6l 35
  • 85.44 (n)
  • 93.34 (a)
chicken
(Gallus gallus)
Aves TAF6L 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAF6L 36
  • 71 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14337 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11073 35
taf6l 35
  • 62.52 (n)
  • 66.9 (a)
zebrafish
(Danio rerio)
Actinopterygii taf6l 35
  • 64.94 (n)
  • 68.45 (a)
taf6l 36
  • 63 (a)
OneToOne
wufa05b10 35
fruit fly
(Drosophila melanogaster)
Insecta mia 36
  • 17 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea taf-6.1 36
  • 13 (a)
OneToMany
taf-6.2 36
  • 11 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF6 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
OneToOne
Species with no ortholog for TAF6L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAF6L Gene

ENSEMBL:
Gene Tree for TAF6L (if available)
TreeFam:
Gene Tree for TAF6L (if available)

Paralogs for TAF6L Gene

Paralogs for TAF6L Gene

Selected SIMAP similar genes for TAF6L Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TAF6L: view

Variants for TAF6L Gene

Sequence variations from dbSNP and Humsavar for TAF6L Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs518668 -- 62,773,604(+) CACCA(C/T)ACCTG intron-variant
rs518780 -- 62,773,648(+) TTTCT(A/G)TGTTG intron-variant
rs544315 -- 62,773,832(-) tttca(C/G)ttcaa intron-variant
rs545204 -- 62,773,741(-) GCTGG(A/G)CCCAG intron-variant
rs545371 -- 62,774,257(+) atttt(A/T)agtag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAF6L Gene

Variant ID Type Subtype PubMed ID
nsv897623 CNV Loss 21882294
nsv483055 CNV Loss 15286789
nsv508636 CNV Loss 20534489
nsv509416 CNV Insertion 20534489
nsv897624 CNV Loss 21882294

Relevant External Links for TAF6L Gene

HapMap Linkage Disequilibrium report
TAF6L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF6L Gene

Disorders for TAF6L Gene

No disorders were found for TAF6L Gene.

No data available for UniProtKB/Swiss-Prot for TAF6L Gene

Publications for TAF6L Gene

  1. Histone-like TAFs within the PCAF histone acetylase complex. (PMID: 9674425) Ogryzko V.V. … Nakatani Y. (Cell 1998) 2 3 4
  2. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage- binding factors in vivo. (PMID: 11564863) Martinez E. … Roeder R.G. (Mol. Cell. Biol. 2001) 3 4
  3. Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one- dimensional gel electrophoresis. (PMID: 12601814) Cavusoglu N. … van Dorsselaer A. (Proteomics 2003) 3 4
  4. The TAFs in the HAT. (PMID: 9674419) Struhl K. … Moqtaderi Z. (Cell 1998) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for TAF6L Gene

Sources for TAF6L Gene

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