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Aliases for TAF6L Gene

Aliases for TAF6L Gene

  • TATA-Box Binding Protein Associated Factor 6 Like 2 3 5
  • TAF6-Like RNA Polymerase II, P300/CBP-Associated Factor (PCAF)-Associated Factor, 65kDa 2 3
  • PCAF-Associated Factor 65-Alpha 3 4
  • PAF65-Alpha 3 4
  • PAF65A 3 4
  • TAF6-Like RNA Polymerase II P300/CBP-Associated Factor-Associated Factor 65 KDa Subunit 6L 3
  • TAF6-Like RNA Polymerase II, P300/CBP-Associated Factor (PCAF)-Associated Factor, 65 KD 2
  • P300/CBP-Associated Factor (PCAF)-Associated Factor 65 3

External Ids for TAF6L Gene

Previous GeneCards Identifiers for TAF6L Gene

  • GC11P065051
  • GC11P064114
  • GC11P062790
  • GC11P062314
  • GC11P062295
  • GC11P062538
  • GC11P058868

Summaries for TAF6L Gene

Entrez Gene Summary for TAF6L Gene

  • Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAF6L Gene

TAF6L (TATA-Box Binding Protein Associated Factor 6 Like) is a Protein Coding gene. Among its related pathways are Chromatin organization and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include protein heterodimerization activity and histone acetyltransferase activity. An important paralog of this gene is TAF6.

UniProtKB/Swiss-Prot for TAF6L Gene

  • Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex.

Gene Wiki entry for TAF6L Gene

Additional gene information for TAF6L Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF6L Gene

Genomics for TAF6L Gene

Regulatory Elements for TAF6L Gene

Enhancers for TAF6L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H062838 1.5 ENCODE dbSUPER 40.4 +69.5 69543 4.8 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A NFYC UBXN1 METTL12 WDR74 NXF1 SNHG1 INTS5 LOC105369332 STX5 MTA2 GANAB
GH11H062551 2.1 FANTOM5 Ensembl ENCODE dbSUPER 22.4 -214.1 -214127 12.9 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF207 EML3 TUT1 MTA2 TAF6L NXF1 LOC105369332 WDR74 STX5 INTS5 TTC9C
GH11H062041 1.4 ENCODE dbSUPER 31.8 -725.9 -725876 8.1 PKNOX1 ARNT ZFP64 FEZF1 ZNF766 FOS SP3 ZC3H11A REST SREBF1 METTL12 CPSF7 SNHG1 GANAB LOC105369332 NXF1 TMEM138 TUT1 INTS5 MTA2
GH11H062887 1.5 Ensembl ENCODE dbSUPER 23.6 +118.5 118457 4 PKNOX1 MLX ARID4B DMAP1 TCF12 ZNF121 ATF7 DEK PAF1 NCOA1 BSCL2 TAF6L SNHG1 SLC3A2 SNORD28 TUT1 SNORD22 SLC22A6 AHNAK TTC9C
GH11H062852 1.7 FANTOM5 ENCODE dbSUPER 18 +84.5 84535 5.9 HNRNPUL1 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 SNHG1 METTL12 NXF1 MTA2 GANAB INTS5 UBXN1 EML3 STX5 LOC105369332
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAF6L on UCSC Golden Path with GeneCards custom track

Promoters for TAF6L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040473 297 1201 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766

Genomic Locations for TAF6L Gene

Genomic Locations for TAF6L Gene
chr11:62,771,303-62,787,342
(GRCh38/hg38)
Size:
16,040 bases
Orientation:
Plus strand
chr11:62,538,775-62,554,814
(GRCh37/hg19)

Genomic View for TAF6L Gene

Genes around TAF6L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF6L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF6L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF6L Gene

Proteins for TAF6L Gene

  • Protein details for TAF6L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6J9-TAF6L_HUMAN
    Recommended name:
    TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L
    Protein Accession:
    Q9Y6J9
    Secondary Accessions:
    • B2RAT0
    • Q96HA6

    Protein attributes for TAF6L Gene

    Size:
    622 amino acids
    Molecular mass:
    67814 Da
    Quaternary structure:
    • The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.

neXtProt entry for TAF6L Gene

Post-translational modifications for TAF6L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAF6L Gene

No data available for DME Specific Peptides for TAF6L Gene

Domains & Families for TAF6L Gene

Gene Families for TAF6L Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TAF6L Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y6J9

UniProtKB/Swiss-Prot:

TAF6L_HUMAN :
  • Belongs to the TAF6 family.
Family:
  • Belongs to the TAF6 family.
genes like me logo Genes that share domains with TAF6L: view

Function for TAF6L Gene

Molecular function for TAF6L Gene

UniProtKB/Swiss-Prot Function:
Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex.

Phenotypes From GWAS Catalog for TAF6L Gene

Gene Ontology (GO) - Molecular Function for TAF6L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 9674425
GO:0003713 transcription coactivator activity IDA 11564863
GO:0004402 contributes_to histone acetyltransferase activity IDA 11564863
GO:0005515 protein binding IPI 9674425
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with TAF6L: view
genes like me logo Genes that share phenotypes with TAF6L: view

Animal Model Products

miRNA for TAF6L Gene

miRTarBase miRNAs that target TAF6L

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAF6L Gene

Localization for TAF6L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF6L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAF6L gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TAF6L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000118 histone deacetylase complex TAS 9674425
GO:0005634 nucleus IDA 11564863
GO:0005654 nucleoplasm IDA --
GO:0030914 STAGA complex IDA 11564863
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with TAF6L: view

Pathways & Interactions for TAF6L Gene

genes like me logo Genes that share pathways with TAF6L: view

Gene Ontology (GO) - Biological Process for TAF6L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006338 chromatin remodeling TAS 9674425
GO:0006351 transcription, DNA-templated IEA --
GO:0006352 DNA-templated transcription, initiation IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9674425
genes like me logo Genes that share ontologies with TAF6L: view

No data available for SIGNOR curated interactions for TAF6L Gene

Drugs & Compounds for TAF6L Gene

(1) Drugs for TAF6L Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
C646 Pharma HAT p300-CBP inhibitor,cell-permeable 0

(1) ApexBio Compounds for TAF6L Gene

Compound Action Cas Number
C646 HAT p300-CBP inhibitor,cell-permeable 328968-36-1
genes like me logo Genes that share compounds with TAF6L: view

Drug Products

Transcripts for TAF6L Gene

Unigene Clusters for TAF6L Gene

TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAF6L Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10
SP1: - - -
SP2: -
SP3: -
SP4:
SP5:

Relevant External Links for TAF6L Gene

GeneLoc Exon Structure for
TAF6L
ECgene alternative splicing isoforms for
TAF6L

Expression for TAF6L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAF6L Gene

Protein differential expression in normal tissues from HIPED for TAF6L Gene

This gene is overexpressed in Plasma (15.7), Liver, secretome (15.5), Pancreas (12.5), and CD8 Tcells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TAF6L Gene



Protein tissue co-expression partners for TAF6L Gene

NURSA nuclear receptor signaling pathways regulating expression of TAF6L Gene:

TAF6L

SOURCE GeneReport for Unigene cluster for TAF6L Gene:

Hs.714400

Evidence on tissue expression from TISSUES for TAF6L Gene

  • Nervous system(3.9)
  • Lung(3.2)
genes like me logo Genes that share expression patterns with TAF6L: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAF6L Gene

Orthologs for TAF6L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAF6L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF6L 33 34
  • 99.62 (n)
cow
(Bos Taurus)
Mammalia TAF6L 33 34
  • 88.75 (n)
dog
(Canis familiaris)
Mammalia TAF6L 33 34
  • 88.51 (n)
oppossum
(Monodelphis domestica)
Mammalia TAF6L 34
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taf6l 33 16 34
  • 85.66 (n)
rat
(Rattus norvegicus)
Mammalia Taf6l 33
  • 85.44 (n)
chicken
(Gallus gallus)
Aves TAF6L 34
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAF6L 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia taf6l 33
  • 62.52 (n)
Str.11073 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.14337 33
zebrafish
(Danio rerio)
Actinopterygii taf6l 33 34
  • 64.94 (n)
wufa05b10 33
fruit fly
(Drosophila melanogaster)
Insecta mia 34
  • 17 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea taf-6.1 34
  • 13 (a)
OneToMany
taf-6.2 34
  • 11 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF6 34
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
OneToOne
Species where no ortholog for TAF6L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAF6L Gene

ENSEMBL:
Gene Tree for TAF6L (if available)
TreeFam:
Gene Tree for TAF6L (if available)

Paralogs for TAF6L Gene

Paralogs for TAF6L Gene

(1) SIMAP similar genes for TAF6L Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TAF6L: view

Variants for TAF6L Gene

Sequence variations from dbSNP and Humsavar for TAF6L Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000009827 -- 62,780,240(+) TTGAA(C/T)CCAGG intron-variant
rs1000011074 -- 62,780,484(+) CCAGC(C/T)TGGGC intron-variant, upstream-variant-2KB
rs1000067794 -- 62,786,746(+) CGACA(C/T)CTACC upstream-variant-2KB, reference, missense
rs1000081793 -- 62,786,984(+) GCCTC(C/T)GAGAG upstream-variant-2KB, reference, synonymous-codon
rs1000506168 -- 62,775,232(+) GGAAA(A/G)GCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAF6L Gene

Variant ID Type Subtype PubMed ID
nsv555175 CNV loss 21841781
nsv509416 CNV insertion 20534489
nsv508636 CNV deletion 20534489
nsv478847 CNV novel sequence insertion 20440878

Variation tolerance for TAF6L Gene

Residual Variation Intolerance Score: 17.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.76; 33.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAF6L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAF6L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF6L Gene

Disorders for TAF6L Gene

Relevant External Links for TAF6L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAF6L

No disorders were found for TAF6L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAF6L Gene

Publications for TAF6L Gene

  1. Histone-like TAFs within the PCAF histone acetylase complex. (PMID: 9674425) Ogryzko VV … Nakatani Y (Cell 1998) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis. (PMID: 12601814) Cavusoglu N … Van Dorsselaer A (Proteomics 2003) 3 4 60
  4. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. (PMID: 11564863) Martinez E … Roeder RG (Molecular and cellular biology 2001) 3 4 60
  5. The TAFs in the HAT. (PMID: 9674419) Struhl K … Moqtaderi Z (Cell 1998) 3 4 60

Products for TAF6L Gene

Sources for TAF6L Gene

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