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TAF6L Gene

protein-coding   GIFtS: 54
GCID: GC11P062538

TAF6-Like RNA Polymerase II, P300/CBP-Associated Factor...

(Previous names: TAF6-like RNA polymerase II, p300/CBP-associated factor...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TAF6-Like RNA Polymerase II, P300/CBP-Associated Factor
(PCAF)-Associated Factor, 65kDa1 2
     TAF6-Like RNA Polymerase II, P300/CBP-Associated Factor (PCAF)-Associated
Factor, 65 KD1
PAF65-alpha2 3     P300/CBP-Associated Factor (PCAF)-Associated Factor 652
PAF65A2 3     PCAF-Associated Factor 65 Alpha2
PCAF-Associated Factor 65-Alpha2 3     TAF6-Like RNA Polymerase II P300/CBP-Associated Factor-Associated Factor
65 KDa Subunit 6L2

External Ids:    HGNC: 173051   Entrez Gene: 106292   Ensembl: ENSG000001622277   OMIM: 6029465   UniProtKB: Q9Y6J93   

Export aliases for TAF6L gene to outside databases

Previous GC identifers: GC11P065051 GC11P064114 GC11P062790 GC11P062314 GC11P062295 GC11P058868


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TAF6L Gene:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein
that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to
position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription
complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a
group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal
transcription, serve as coactivators, function in promoter recognition or modify general transcription factors
(GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a
component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6.
The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is
required for myogenic transcription and differentiation. (provided by RefSeq, Jul 2008)

GeneCards Summary for TAF6L Gene:
TAF6L (TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa) is a protein-coding gene. Diseases associated with TAF6L include brain cancer, and herpes simplex. GO annotations related to this gene include histone acetyltransferase activity and protein heterodimerization activity. An important paralog of this gene is TAF6.

UniProtKB/Swiss-Prot: TAF6L_HUMAN, Q9Y6J9
Function: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating
histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA
complex

Gene Wiki entry for TAF6L Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TAF6L gene promoter:
         ER-alpha   RFX1   p53   p300   MyoD   FOXD1   XBP-1   E2F-1   E2F   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAF6L promoter sequence
   Search Chromatin IP Primers for TAF6L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAF6L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.3   Ensembl cytogenetic band:  11q12.3   HGNC cytogenetic band: 11q12.3

TAF6L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAF6L gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P062538:  view genomic region     (about GC identifiers)

Start:
62,538,775 bp from pter      End:
62,554,814 bp from pter
Size:
16,040 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TAF6L_HUMAN, Q9Y6J9 (See protein sequence)
Recommended Name: TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L  
Size: 622 amino acids; 67814 Da
Subunit: The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6,
TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and
SPT3. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L,
TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9
Secondary accessions: B2RAT0 Q96HA6

Explore the universe of human proteins at neXtProt for TAF6L: NX_Q9Y6J9

Explore proteomics data for TAF6L at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TAF6L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006464.1  
    ENSEMBL proteins: 
     ENSP00000294168   ENSP00000435116   ENSP00000435443   ENSP00000434662  
    Reactome Protein details: Q9Y6J9

    TAF6L Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR011442 DUF1546
     IPR009072 Histone-fold
     IPR004823 TAF_TATA-bd

    Graphical View of Domain Structure for InterPro Entry Q9Y6J9

    ProtoNet protein and cluster: Q9Y6J9

    1 Blocks protein domain: IPB011442 Protein of unknown function DUF1546

    UniProtKB/Swiss-Prot: TAF6L_HUMAN, Q9Y6J9
    Similarity: Belongs to the TAF6 family


    TAF6L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAF6L_HUMAN, Q9Y6J9
    Function: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating
    histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA
    complex

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS9674425
    GO:0003713transcription coactivator activity IDA11564863
    GO:0004402contributes to histone acetyltransferase activity IDA11564863
    GO:0005515protein binding IPI16713569
    GO:0046982protein heterodimerization activity IEA--
         
    TAF6L for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TAF6L:
     Decreased TP53 protein express  Increased HPV18 LCR reporter a 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TAF6L
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    miRNA
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    miRTarBase miRNAs that target TAF6L:
    hsa-mir-106b-5p (MIRT020438)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TAF6L_HUMAN, Q9Y6J9: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000118histone deacetylase complex TAS9674425
    GO:0005634nucleus ----
    GO:0030914STAGA complex IDA11564863

    TAF6L for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TAF6L About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Assembly of RNA Polymerase-II Initiation Complex
    Assembly of RNA Polymerase-II Initiation Complex0.91
    Basal transcription factors0.50
    Transcription of mRNA0.91
    Crosstalk Between CARM1 and ESRs0.39
    Protein Acetylation and Deacetylation0.51
    2RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34
    3Apoptotic Pathways in Synovial Fibroblasts
    Nuclear Receptor Activation by Vitamin-A0.57
    4GPCR Pathway
    Estrogen Pathway0.55
    5PEDF Induced Signaling
    Glucocorticoid Receptor Signaling0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for TAF6L
        Notch Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TAF6L (see all 7)
        Nuclear Receptor Activation by Vitamin-A
    Protein Acetylation and Deacetylation
    Assembly of RNA Polymerase-II Initiation Complex
    Glucocorticoid Receptor Signaling
    Estrogen Pathway

    1 GeneGo (Thomson Reuters) Pathway for TAF6L
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 Reactome Pathway for TAF6L
        HATs acetylate histones


    2 Kegg Pathways  (Kegg details for TAF6L):
        Basal transcription factors
    Herpes simplex infection


    TAF6L for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TAF6L
    Interactions:

        Search GeneGlobe Interaction Network for TAF6L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TAF6L (Q9Y6J91, 2, 3 ENSP000002941684) via UniProtKB, MINT, STRING, and/or I2D (see all 138)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAF9Q165941, 2, 3, ENSP000002178934EBI-743984,EBI-712521 MINT-2868626 I2D: score=5 STRING: ENSP00000370201 STRING: ENSP00000217893
    STX11O755582, 3, ENSP000003565404MINT-66418 I2D: score=5 STRING: ENSP00000356540
    KAT2AQ928303, ENSP000002259164I2D: score=2 STRING: ENSP00000225916
    TAF10Q129623, ENSP000002994244I2D: score=1 STRING: ENSP00000299424
    KAT2BQ928313, ENSP000002637544I2D: score=2 STRING: ENSP00000263754
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006325chromatin organization TAS--
    GO:0006338chromatin remodeling TAS9674425
    GO:0006352DNA-templated transcription, initiation IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9674425
    GO:0043966histone H3 acetylation IDA11564863

    TAF6L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TAF6L



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TAF6L gene: 
    NM_006473.3  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000294168(uc001nvc.3) ENST00000526261 ENST00000525405 ENST00000524976(uc009yof.3)
    ENST00000532915(uc010rmg.2) ENST00000529509 ENST00000531265 ENST00000533823

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    Selected AceView cDNA sequences (see all 200):

    AF069735 AA379451 BI019084 AI279305 AI224975 BE671838 AW271447 AI028032 
    AI813433 NM_006473 AI469854 AA973102 BQ186037 C01919 AW772493 AW517218 
    BC008785 AI524252 AI858045 BE673339 AW007474 AA416998 AI582286 AI360158 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TAF6L    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10
    SP1:                                                  -           -                       -         
    SP2:              -                                                                                 
    SP3:                                                              -                                 
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for TAF6L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TAF6L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCGGCCGTA
    TAF6L Expression
    About this image

    TAF6L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TAF6L Protein Expression
        Custom PCR Arrays for TAF6L
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF6L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TAF6L gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Taf6l1 , 5 TAF6-like RNA polymerase II, p300/CBP-associated factor more1, 5 85.66(n)1
    93.51(a)1
      19 (5.56 cM)5
    2258951  NM_146092.21  NP_666204.21 
     87743545 
    chicken
    (Gallus gallus)
    Aves TAF6L6
    TAF6-like RNA polymerase II, p300/CBP-associated f...
    76(a)
    1 ↔ 1
    JH375637.1(9182-10876)
    lizard
    (Anolis carolinensis)
    Reptilia TAF6L6
    TAF6-like RNA polymerase II, p300/CBP-associated f...
    71(a)
    1 ↔ 1
    GL344077.1(5429-20957)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.143372 Xenopus laevis transcribed sequence with weak similarity more 75.55(n)    48035604 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa05b102 wufa05b10 81.54(n)   334849  57097137 
    fruit fly
    (Drosophila melanogaster)
    Insecta mia6
    meiosis I arrest
    17(a)
    1 ↔ 1
    3R(1374048-1376889)
    worm
    (Caenorhabditis elegans)
    Secernentea taf-6.16
    taf-6.26
    --
    13(a)
    11(a)
    1 ↔ many
    1 ↔ many
    II(1127976-1132347) WBGene00006387
    IV(3687383-3694743) WBGene00021363
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TAF66
    Subunit (60 kDa) of TFIID and SAGA complexes, invo...
    18(a)
    1 → many
    VII(298178-299728) YGL112C


    ENSEMBL Gene Tree for TAF6L (if available)
    TreeFam Gene Tree for TAF6L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TAF6L gene
    TAF62  
    1 SIMAP similar gene for TAF6L using alignment to 5 protein entries:     TAF6L_HUMAN (see all proteins):
    TAF6

    TAF6L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TAF6L (see all 361)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1844129481,2
    --62537110(+) TCCCAG/TCTGTG 1 -- us2k10--------
    rs1895163561,2
    --62537251(+) ATCTTC/TTAGTG 1 -- us2k10--------
    rs1817853831,2
    --62537529(+) TCGGGG/TCCCAG 1 -- us2k10--------
    rs1860894821,2
    --62537576(+) TGAGAA/GGGGGA 1 -- us2k10--------
    rs1505628441,2
    --62537654(+) CCCCAC/TCTTGG 1 -- us2k10--------
    rs1487905971,2
    C--62537687(+) ATGCC-/TTTGTG 1 -- us2k10--------
    rs5933341,2
    C,F,A--62537847(-) TAATCG/CCAGCT 1 -- us2k12Minor allele frequency- C:0.50WA CSA 4
    rs1891667551,2
    --62537872(+) CACACA/CCGGCT 1 -- us2k10--------
    rs1815767791,2
    --62537954(+) GTGATC/TCCCCG 1 -- us2k10--------
    rs710565621,2
    C--62538005(+) CCGCG-/CCCGGC 1 -- us2k12Minor allele frequency- C:0.25NA 4

    HapMap Linkage Disequilibrium report for TAF6L (62538775 - 62554814 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TAF6L:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509416CNV Insertion20534489
    nsv897624CNV Loss21882294
    nsv483055CNV Loss15286789
    nsv508636CNV Loss20534489
    nsv897623CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 602946    OMIM disorders: --

    3 diseases for TAF6L:    
    About MalaCards
    brain cancer    herpes simplex    ataxia


    TAF6L for disorders           About GeneDecksing


    Export disorders for TAF6L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TAF6L gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with TAF6L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Histone-like TAFs within the PCAF histone acetylase complex. (PubMed id 9674425)1, 2, 3 Ogryzko V.V.... Nakatani Y. (Cell 1998)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one- dimensional gel electrophoresis. (PubMed id 12601814)1, 2 Cavusoglu N.... van Dorsselaer A. (Proteomics 2003)
    4. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage- binding factors in vivo. (PubMed id 11564863)1, 2 Martinez E.... Roeder R.G. (Mol. Cell. Biol. 2001)
    5. The TAFs in the HAT. (PubMed id 9674419)1, 2 Struhl K. and Moqtaderi Z. (Cell 1998)
    6. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    7. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 10629 HGNC: 17305 AceView: TAF6L Ensembl:ENSG00000162227 euGenes: HUgn10629
    ECgene: TAF6L Kegg: 10629 H-InvDB: TAF6L

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TAF6L Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TAF6L Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TAF6L gene:
    Search GeneIP for patents involving TAF6L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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