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Aliases for TAF6 Gene

Aliases for TAF6 Gene

  • TAF6 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 80kDa 2 3
  • TAFII80 3 4 6
  • TAF2E 3 4 6
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, E, 70/85kD 2 3
  • Transcription Initiation Factor TFIID 70 KDa Subunit 3 4
  • RNA Polymerase II TBP-Associated Factor Subunit E 3 4
  • TAF(II)70 3 4
  • TAF(II)80 3 4
  • TAFII-70 3 4
  • TAFII-80 3 4
  • TAFII70 3 4
  • Transcription Initiation Factor TFIID 80 KDa Subunit 4
  • Transcription Initiation Factor TFIID 70 KD Subunit 2
  • TATA Box Binding Protein (TBP)-Associated Factor 2
  • Transcription Initiation Factor TFIID Subunit 6 3
  • TAF6 RNA Polymerase II 2
  • MGC:8964 3
  • TAFII85 3
  • 80 KD 2

External Ids for TAF6 Gene

Previous Symbols for TAF6 Gene

  • TAF2E

Summaries for TAF6 Gene

Entrez Gene Summary for TAF6 Gene

  • Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

GeneCards Summary for TAF6 Gene

TAF6 (TAF6 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 80kDa) is a Protein Coding gene. Among its related pathways are Disease and GPCR Pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is TAF6L.

UniProtKB/Swiss-Prot for TAF6 Gene

  • TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors

Gene Wiki entry for TAF6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF6 Gene

Genomics for TAF6 Gene

Genomic Location for TAF6 Gene

Start:
100,107,070 bp from pter
End:
100,119,858 bp from pter
Size:
12,789 bases
Orientation:
Minus strand

Genomic View for TAF6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF6 Gene

Regulatory Elements for TAF6 Gene

Proteins for TAF6 Gene

  • Protein details for TAF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49848-TAF6_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 6
    Protein Accession:
    P49848
    Secondary Accessions:
    • A4D2B2
    • A4D2B3
    • B4DT11
    • D6W5U2
    • Q6AI29

    Protein attributes for TAF6 Gene

    Size:
    677 amino acids
    Molecular mass:
    72668 Da
    Quaternary structure:
    • TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC. Interacts directly with TBP, TAF1/TAFII250, TAF9/TAFII31 AND TAF12/TAFII20. The TAF6/TAFII70-TAF9/TAFII31 heterodimer forms an octamer complex with the TAF4B/TFII105-TAF12/TFIID20 heterodimer. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Also interacts with the GTFs, TFIIEalpha/GTF2E1 and TFIIFalpha/GTF2F1. Component of the TFTC-HAT complex.

    Alternative splice isoforms for TAF6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAF6 Gene

Proteomics data for TAF6 Gene at MOPED

Post-translational modifications for TAF6 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys78

No data available for DME Specific Peptides for TAF6 Gene

Domains for TAF6 Gene

UniProtKB/Swiss-Prot:

TAF6_HUMAN
Family:
  • Belongs to the TAF6 family.:
    • P49848
genes like me logo Genes that share domains with TAF6: view

No data available for Gene Families for TAF6 Gene

Function for TAF6 Gene

Molecular function for TAF6 Gene

UniProtKB/Swiss-Prot Function: TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors

Gene Ontology (GO) - Molecular Function for TAF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 15601843
GO:0003700 contributes_to sequence-specific DNA binding transcription factor activity IDA 9603525
GO:0005488 binding --
GO:0005515 protein binding IPI 15328371
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with TAF6: view

Phenotypes for TAF6 Gene

GenomeRNAi human phenotypes for TAF6:
genes like me logo Genes that share phenotypes with TAF6: view

miRNA for TAF6 Gene

miRTarBase miRNAs that target TAF6

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TAF6 Gene

Localization for TAF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAF6 Gene COMPARTMENTS Subcellular localization image for TAF6 gene
Compartment Confidence
nucleus 5
cytosol 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for TAF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex IDA 14580349
GO:0005737 cytoplasm IDA --
GO:0033276 transcription factor TFTC complex IDA 9603525
genes like me logo Genes that share ontologies with TAF6: view

Pathways for TAF6 Gene

genes like me logo Genes that share pathways with TAF6: view

Gene Ontology (GO) - Biological Process for TAF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006352 DNA-templated transcription, initiation IDA 9603525
GO:0006355 regulation of transcription, DNA-templated IDA 15328371
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with TAF6: view

Transcripts for TAF6 Gene

Unigene Clusters for TAF6 Gene

TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAF6 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b ^ 11a · 11b · 11c ·
SP1: -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - -
SP8: - - - - - - - - - -
SP9: - - - - - - -
SP10: - - - - -
SP11: - - - -
SP12: - -
SP13:
SP14: - - - - - - - - - - -
SP15: - - - - - -
SP16: - - -
SP17: - - -
SP18:
SP19: - - - -
SP20:

ExUns: 11d ^ 12 ^ 13 ^ 14 ^ 15
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:

Relevant External Links for TAF6 Gene

GeneLoc Exon Structure for
TAF6
ECgene alternative splicing isoforms for
TAF6

Expression for TAF6 Gene

mRNA expression in normal human tissues for TAF6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAF6 Gene

SOURCE GeneReport for Unigene cluster for TAF6 Gene Hs.489309

genes like me logo Genes that share expressions with TAF6: view

Orthologs for TAF6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAF6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF6 36
  • 99.3 (n)
  • 99.86 (a)
TAF6 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAF6 36
  • 89.56 (n)
  • 97.49 (a)
TAF6 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAF6 36
  • 90.25 (n)
  • 98.23 (a)
TAF6 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taf6 36
  • 87.33 (n)
  • 97.78 (a)
Taf6 16
Taf6 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAF6 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAF6 37
  • 47 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Taf6 36
  • 87.92 (n)
  • 98.91 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC397724 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4679 36
taf6 36
  • 77.31 (n)
  • 86.15 (a)
zebrafish
(Danio rerio)
Actinopterygii taf6 36
  • 68.25 (n)
  • 76.95 (a)
taf6 37
  • 72 (a)
OneToOne
wufb83e08 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004254 36
  • 58.24 (n)
  • 55.88 (a)
fruit fly
(Drosophila melanogaster)
Insecta Taf6 36
  • 61.5 (n)
  • 56.18 (a)
Taf6 37
  • 45 (a)
OneToOne
Taf6 38
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea taf-6.1 36
  • 41.55 (n)
  • 28.33 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL020W 36
  • 45.05 (n)
  • 33.11 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF6 36
  • 42.97 (n)
  • 35.68 (a)
TAF6 37
  • 25 (a)
OneToMany
TAF6 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F10659g 36
  • 44.27 (n)
  • 34.93 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU07757 36
  • 49.86 (n)
  • 37.46 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes taf6 36
  • 46.32 (n)
  • 40 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9313 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 62 (a)
OneToOne
Species with no ortholog for TAF6:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAF6 Gene

ENSEMBL:
Gene Tree for TAF6 (if available)
TreeFam:
Gene Tree for TAF6 (if available)

Paralogs for TAF6 Gene

Paralogs for TAF6 Gene

genes like me logo Genes that share paralogs with TAF6: view

Variants for TAF6 Gene

Sequence variations from dbSNP and Humsavar for TAF6 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs2272338 -- 100,110,089(-) TGTCC(C/T)TTTCC intron-variant
rs3837088 -- 100,109,643(+) GACAC(-/AT)GTCAC intron-variant
rs4134887 -- 100,116,597(-) aatga(C/T)acaga intron-variant
rs4134888 -- 100,116,427(-) tcctg(A/C)cctca intron-variant
rs4134889 -- 100,116,307(-) taagc(C/T)caagc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAF6 Gene

Variant ID Type Subtype PubMed ID
nsv469687 CNV Loss 16826518
esv2734888 CNV Deletion 23290073
nsv824235 CNV Gain 20364138

Relevant External Links for TAF6 Gene

HapMap Linkage Disequilibrium report
TAF6
Human Gene Mutation Database (HGMD)
TAF6

Disorders for TAF6 Gene

(1) University of Copenhagen DISEASES for TAF6 Gene

genes like me logo Genes that share disorders with TAF6: view

No data available for UniProtKB/Swiss-Prot for TAF6 Gene

Publications for TAF6 Gene

  1. Evolutionary conservation of human TATA-binding-polypeptide- associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors. (PMID: 7667268) Hisatake K. … Roeder R.G. (Proc. Natl. Acad. Sci. U.S.A. 1995) 3 4 23
  2. TAFII70 isoform-specific growth suppression correlates with its ability to complex with the GADD45a protein. (PMID: 15328371) Wang W. … Marks J.R. (Mol. Cancer Res. 2004) 3 23
  3. Induced alpha-helix structure in the aryl hydrocarbon receptor transactivation domain modulates protein-protein interactions. (PMID: 15641800) Watt K. … McEwan I.J. (Biochemistry 2005) 3 23
  4. Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one- dimensional gel electrophoresis. (PMID: 12601814) Cavusoglu N. … van Dorsselaer A. (Proteomics 2003) 3 4
  5. Discussion paper: experimental and clinical immunopharmacology data applicable to cancer immunotherapy. (PMID: 826207) MathAc G. … Simmler M.C. (Ann. N. Y. Acad. Sci. 1976) 2 3

Products for TAF6 Gene

Sources for TAF6 Gene

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