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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAF6 Gene

protein-coding   GIFtS: 63
GCID: GC07M099704

TAF6 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated...

(Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase...)
(Previous symbol: TAF2E)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
TAF6 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated
Factor, 80kDa1 2
     RNA Polymerase II TBP-Associated Factor Subunit E2 3
TAF2E1 2 3 5     80 KD1
TAFII802 3 5     TAF6 RNA Polymerase II1
TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, E,
70/85kD1 2
     TATA Box Binding Protein (TBP)-Associated Factor1
Transcription Initiation Factor TFIID 70 KDa Subunit2 3     Transcription Initiation Factor TFIID 70 KD Subunit1
TAF(II)702 3     MGC:89642
TAF(II)802 3     TAFII852
TAFII-702 3     Transcription Initiation Factor TFIID Subunit 62
TAFII-802 3     Transcription Initiation Factor TFIID 80 KDa Subunit3
TAFII702 3     

External Ids:    HGNC: 115401   Entrez Gene: 68782   Ensembl: ENSG000001062907   OMIM: 6029555   UniProtKB: P498483   
ORGUL members:         
NONCODE14:n409395 n337262      

Export aliases for TAF6 gene to outside databases

Previous GC identifers: GC07M098239 GC07M099302 GC07M099316 GC07M099351 GC07M099542 GC07M094340


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TAF6 Gene:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein
that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to
position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription
complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a
group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal
transcription, serve as coactivators, function in promoter recognition or modify general transcription factors
(GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits
of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing
results in multiple transcript variants. (provided by RefSeq, Jun 2010)

GeneCards Summary for TAF6 Gene: 
TAF6 (TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with TAF6 include bare lymphocyte syndrome, and progeria, and among its related super-pathways are RNA Polymerase II Pre-transcription Events and Assembly of RNA Polymerase-II Initiation Complex. GO annotations related to this gene include protein heterodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TAF6L.

UniProtKB/Swiss-Prot: TAF6_HUMAN, P49848
Function: TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and
TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating
promoter responses to various activators and repressors

Gene Wiki entry for TAF6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAF6 gene promoter:
         NRSF form 1   NRSF form 2   Tal-1beta   HNF-1A   Arnt   E47   CREB   FAC1   HNF-1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAF6 promoter sequence
   Search SABiosciences Chromatin IP Primers for TAF6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAF6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q

TAF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAF6 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M099704:  view genomic region     (about GC identifiers)

Start:
99,704,693 bp from pter      End:
99,717,481 bp from pter
Size:
12,789 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 99,064,811-99,077,600     
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for TAF6

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TAF6_HUMAN, P49848 (See protein sequence)
Recommended Name: Transcription initiation factor TFIID subunit 6  
Size: 677 amino acids; 72668 Da
Subunit: TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs).
TBP is not part of TFTC. Interacts directly with TBP, TAF1/TAFII250, TAF9/TAFII31 AND TAF12/TAFII20. The
TAF6/TAFII70-TAF9/TAFII31 heterodimer forms an octamer complex with the TAF4B/TFII105-TAF12/TFIID20 heterodimer.
Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5
and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1,
MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and
TEX10. Also interacts with the GTFs, TFIIEalpha/GTF2E1 and TFIIFalpha/GTF2F1. Component of the TFTC-HAT complex
Subcellular location: Nucleus
Secondary accessions: A4D2B2 A4D2B3 B4DT11 D6W5U2 Q6AI29
Alternative splicing: 3 isoforms:  P49848-1   P49848-2   P49848-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TAF6: NX_P49848

Explore proteomics data for TAF6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P49848

  • TAF6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TAF6 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001177344.1  NP_005632.1  NP_647476.1  

    ENSEMBL proteins: 
     ENSP00000413614   ENSP00000389575   ENSP00000419760   ENSP00000416396   ENSP00000344537  
     ENSP00000399982   ENSP00000419555   ENSP00000410012   ENSP00000412346   ENSP00000428639  
     ENSP00000390073   ENSP00000428071   ENSP00000406315   ENSP00000390220   ENSP00000395627  
     ENSP00000427710   ENSP00000407980  
    Reactome Protein details: P49848
    Human Recombinant Protein Products for TAF6: 
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    Cloud-Clone Corp. Proteins for TAF6 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005669transcription factor TFIID complex IDA14580349
    GO:0005737cytoplasm IDA--
    GO:0033276transcription factor TFTC complex IDA9603525

    TAF6 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR011442 DUF1546
     IPR011989 ARM-like
     IPR009072 Histone-fold
     IPR004823 TAF_TATA-bd

    Graphical View of Domain Structure for InterPro Entry P49848

    ProtoNet protein and cluster: P49848

    2 Blocks protein domains:
    IPB004823 TATA box binding protein associated factor (TAF)
    IPB011442 Protein of unknown function DUF1546


    UniProtKB/Swiss-Prot: TAF6_HUMAN, P49848
    Similarity: Belongs to the TAF6 family


    TAF6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAF6_HUMAN, P49848
    Function: TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and
    TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating
    promoter responses to various activators and repressors

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA15601843
    GO:0003700contributes to sequence-specific DNA binding transcription factor activity IDA9603525
    GO:0005488binding ----
    GO:0005515protein binding IPI15328371
    GO:0046982protein heterodimerization activity IEA--
         
    TAF6 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TAF6:
     Synthetic lethal with Ras 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidTAF6 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TAF6 About   (see all 12)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    RNA Polymerase II Pre-transcription Events0.72
    RNA Polymerase II Transcription Pre-Initiation And Promoter Opening0.67
    Transcription of the HIV genome0.70
    HIV Transcription Initiation0.67
    RNA Polymerase II Transcription Initiation And Promoter Clearance0.67
    RNA Polymerase II Transcription Initiation0.67
    RNA Polymerase II Promoter Escape0.67
    Eukaryotic Transcription Initiation0.60
    2Assembly of RNA Polymerase-II Initiation Complex
    Assembly of RNA Polymerase-II Initiation Complex0.91
    Basal transcription factors0.50
    Transcription of mRNA0.91
    Crosstalk Between CARM1 and ESRs0.39
    Protein Acetylation and Deacetylation0.51
    3HIV Life Cycle
    HIV Life Cycle0.92
    HIV Infection0.61
    Late Phase of HIV Life Cycle0.92
    4Transcription
    Transcription0.69
    RNA Polymerase II Transcription0.69
    5Apoptotic Pathways in Synovial Fibroblasts
    Nuclear Receptor Activation by Vitamin-A0.57

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for TAF6
        Histone modification
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TAF6 (see all 7)
        Nuclear Receptor Activation by Vitamin-A
    Protein Acetylation and Deacetylation
    Assembly of RNA Polymerase-II Initiation Complex
    Glucocorticoid Receptor Signaling
    Estrogen Pathway

    1 GeneGo (Thomson Reuters) Pathway for TAF6
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 BioSystems Pathway for TAF6
        Eukaryotic Transcription Initiation

    5/15        Reactome Pathways for TAF6 (see all 15)
        RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
    Late Phase of HIV Life Cycle
    RNA Polymerase II Transcription
    Transcription
    RNA Polymerase II Transcription Initiation And Promoter Clearance


    2         Kegg Pathways  (Kegg details for TAF6):
        Basal transcription factors
    Herpes simplex infection


    TAF6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TAF6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/233 Interacting proteins for TAF6 (P498482, 3 ENSP000003445374) via UniProtKB, MINT, STRING, and/or I2D (see all 233)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=2 
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    HIST1H4EP628053I2D: score=2 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006352DNA-dependent transcription, initiation IDA9603525
    GO:0006355regulation of transcription, DNA-dependent IDA15328371
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--

    TAF6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

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    Search CenterWatch for drugs/clinical trials and news about TAF6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TAF6 gene (5 alternative transcripts): 
    NM_001190415.1  NM_005641.3  NM_139315.2  NM_139122.1  NM_139123.1  

    Unigene Cluster for TAF6:

    TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
    Hs.489309  [show with all ESTs]
    Unigene Representative Sequence: NM_005641
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000421980 ENST00000453269(uc003utg.3 uc003uti.3 uc003utk.3)
    ENST00000472509(uc003uth.3) ENST00000452041 ENST00000344095(uc003utm.3)
    ENST00000437822(uc011kji.2) ENST00000487115 ENST00000487288 ENST00000493322
    ENST00000440225 ENST00000452438 ENST00000523306 ENST00000449571 ENST00000520135
    ENST00000451699 ENST00000417349 ENST00000431404 ENST00000460673
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK097781.1 AK300005.1 AK314428.1 AK315077.1 BC018115.1 BC127819.1 CR627390.1 L25444.1 
    NR_033792.1 U31659.1 

    24/28 DOTS entries (see all 28):

    DT.450124  DT.100723809  DT.92468297  DT.100044202  DT.100645712  DT.100723786  DT.100767792  DT.100059866 
    DT.100723768  DT.100723802  DT.100723777  DT.97774211  DT.100059865  DT.100723773  DT.40255906  DT.95273993 
    DT.100876224  DT.121080631  DT.92468307  DT.100051569  DT.121080669  DT.121080706  DT.92468322  DT.92468328 

    24/175 AceView cDNA sequences (see all 175):

    AW385317 CD636888 BQ962884 BQ440506 F02888 BX396535 BU508273 NM_139123 
    F01478 BM557210 BM806299 NM_005641 AK097781 BM458212 CF243183 NM_139122 
    L25444 BQ223742 BQ672390 CR624352 BU169243 BQ072075 NM_139315 AU124861 

    GeneLoc Exon Structure

    5/20 Alternative Splicing Database (ASD) splice patterns (SP) for TAF6 (see all 20)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d · 9e ^ 10a · 10b ^ 11a · 11b · 11c ·
    SP1:                                                                                                                                -                           
    SP2:                                            -     -     -     -     -     -                                                     -                           
    SP3:                                            -     -     -     -     -                                                           -                           
    SP4:                                            -     -           -     -                                                           -                           
    SP5:                                            -     -     -     -     -                                                           -     -                     

    ExUns: 11d ^ 12 ^ 13 ^ 14 ^ 15
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for TAF6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TAF6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCACTTTCTT
    TAF6 Expression
    About this image


    See TAF6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TAF6

    SOURCE GeneReport for Unigene cluster: Hs.489309
        SABiosciences Custom PCR Arrays for TAF6
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TAF6 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Taf61 , 5 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated more1, 5 87.33(n)1
    97.78(a)1
      5 (76.98 cM)5
    213431  NM_009315.31  NP_033341.11 
     1381786175 
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3977242 TFIID subunit 74.58(n)    D50054.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb83e082 Transcribed sequence with weak similarity to protein more 73.96(n)    CK024464.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Taf61 , 3 transcription initiation from Pol II
    promoter more3
    TBP-associated factor 61
    48(a)3
    57.8(n)1
    50.27(a)1
      3 76B93
    401341  NM_079437.31  NP_524161.21 
    worm
    (Caenorhabditis elegans)
    Secernentea taf-6.11 Protein TAF-6.1 40.89(n)
    27.84(a)
      173498  NM_061518.4  NP_493919.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TAF6(YGL112C)4 Subunit (60 kDa) of TFIID and SAGA complexes, involved more   --   7(299728-298178) 852766  NP_011403.1 


    ENSEMBL Gene Tree for TAF6 (if available)
    TreeFam Gene Tree for TAF6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TAF6 gene
    TAF6L2  
    1 SIMAP similar gene for TAF6 using alignment to 15 protein entries:     TAF6_HUMAN (see all proteins):
    TAF6L

    TAF6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/471 SNPs in TAF6 are shown (see all 471)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs119748141,2
    C,F,H--94355045(+) ctgtcC/Tctact 1 -- us2k13Minor allele frequency- T:0.50NA WA 6
    rs1841142021,2
    --94355072(+) TAGCCC/GGGCGT 1 -- us2k10--------
    rs102257231,2
    C--94355108(+) tactcA/Gggaga 1 -- us2k10--------
    rs1138211981,2
    F--99066936(+) GGCGCG/ATGCCT 4 -- int11Minor allele frequency- A:0.50CSA 2
    rs2002193901,2
    --99068737(+) AAAAA-/AAGGTATT 4 -- int10--------
    rs41349041,2
    C,F--99070704(-) TTTTCC/-TACTA 4 -- int14Minor allele frequency- -:0.32NS NA CSA 174
    rs711263051,2
    C--99075796(-) TTTTTT/-TTTTT 4 -- int11Minor allele frequency- -:0.00NA 2
    rs556923701,2
    C--99075804(+) AAAAAA/CAAAAA 4 -- int10--------
    rs38370881,2
    C,F--99707266(+) GACACAT/-GTCAC 4 -- int12Minor allele frequency- -:0.13NS CSA 160
    rs113670151,2
    C,F--99708603(+) ATCTC-/AAAAAA 4 -- int1 trp32Minor allele frequency- A:0.50NA CSA 4

    HapMap Linkage Disequilibrium report for TAF6 (99704693 - 99717481 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TAF6:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2734888CNV Deletion23290073
    nsv469687CNV Loss16826518
    nsv824235CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602955    OMIM disorders: --

    3 diseases for TAF6:    About MalaCards
    bare lymphocyte syndrome    progeria    maturity-onset diabetes of the young

    1 disease from the University of Copenhagen DISEASES database for TAF6:
    maturity-onset diabetes of the young

    TAF6 for disorders           About GeneDecksing


    Export disorders for TAF6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TAF6 gene, integrated from 9 sources (see all 86):
    (articles sorted by number of sources associating them with TAF6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Evolutionary conservation of human TATA-binding-polypeptide- associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors. (PubMed id 7667268)1, 2, 9 Hisatake K.... Roeder R.G. (1995)
    2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    3. Core promoter binding by histone-like TAF complexes. (PubMed id 15601843)1, 2 Shao H.... Dikstein R. (2005)
    4. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PubMed id 15960975)1, 2 Dou Y.... Roeder R.G. (2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    8. Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one- dimensional gel electrophoresis. (PubMed id 12601814)1, 2 Cavusoglu N.... van Dorsselaer A. (2003)
    9. Cloning and expression of Drosophila TAFII60 and human TAFII70 reveal conserved interactions with other subunits of TFIID. (PubMed id 8262073)1, 2 Weinzierl R.O.... Tjian R. (1993)
    10. Discussion paper: experimental and clinical immunopharmacology data applicable to cancer immunotherapy. (PubMed id 826207)1, 3 Mathe G....Simmler M.C. (1976)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6878 HGNC: 11540 AceView: TAF6 Ensembl:ENSG00000106290 euGenes: HUgn6878
    ECgene: TAF6 Kegg: 6878 H-InvDB: TAF6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TAF6 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/taf6/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TAF6 gene:
    Search GeneIP for patents involving TAF6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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