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Aliases for TAF5L Gene

Aliases for TAF5L Gene

  • TATA-Box Binding Protein Associated Factor 5 Like 2 3 5
  • TAF5-Like RNA Polymerase II, P300/CBP-Associated Factor (PCAF)-Associated Factor, 65kDa 2 3
  • PCAF-Associated Factor 65 Beta 3 4
  • PAF65-Beta 3 4
  • PAF65B 3 4
  • TAF5-Like RNA Polymerase II P300/CBP-Associated Factor-Associated Factor 65 KDa Subunit 5L 3
  • TAF5-Like RNA Polymerase II, P300/CBP-Associated Factor (PCAF)-Associated Factor, 65 KD 2
  • PCAF Associated Factor 65 Beta 2

External Ids for TAF5L Gene

Previous GeneCards Identifiers for TAF5L Gene

  • GC01M228175
  • GC01M225423
  • GC01M226128
  • GC01M226690
  • GC01M226035
  • GC01M227795
  • GC01M229728
  • GC01M200221

Summaries for TAF5L Gene

Entrez Gene Summary for TAF5L Gene

  • The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAF5L Gene

TAF5L (TATA-Box Binding Protein Associated Factor 5 Like) is a Protein Coding gene. Among its related pathways are Chromatin organization and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and histone acetyltransferase activity. An important paralog of this gene is TAF5.

UniProtKB/Swiss-Prot for TAF5L Gene

  • Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex.

Gene Wiki entry for TAF5L Gene

Additional gene information for TAF5L Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF5L Gene

Genomics for TAF5L Gene

Regulatory Elements for TAF5L Gene

Enhancers for TAF5L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H228781 1.9 FANTOM5 Ensembl ENCODE dbSUPER 36.9 +843.0 842985 3 FEZF1 ZNF2 ZNF302 ZNF416 FOS REST KAT8 MIER3 ZNF610 ZSCAN16 NUP133 CICP26 C1orf35 ENSG00000269890 HMGN2P19 HIST3H3 TAF5L ABCB10 PRSS38 URB2
GH01H229219 2 FANTOM5 Ensembl ENCODE dbSUPER 20.4 +404.1 404101 4 HDGF PKNOX1 FOXA2 ARNT ARID4B YBX1 FEZF1 DMAP1 ZNF2 YY1 NUP133 ENSG00000269890 URB2 HMGN2P19 HIST3H3 LOC105373158 TAF5L ENSG00000233920 ENSG00000226920 LOC100421842
GH01H230121 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -498.7 -498744 5 HDGF PKNOX1 ARNT YBX1 ZNF766 CBX5 ZNF143 JUNB REST SMARCB1 NUP133 TAF5L URB2 ABCB10 COG2 GALNT2 GC01P230113 GC01M230200
GH01H230082 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11 -461.7 -461720 10 PKNOX1 FOXA2 SIN3A FEZF1 GLI4 ZNF2 TCF12 GLIS2 FOS DEK NUP133 HMGN2P19 TAF5L ENSG00000224407 GC01P230113 GALNT2
GH01H228840 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +784.0 784016 2 PKNOX1 ATF1 ZNF2 ZNF548 ATF7 FOS DEK REST TSHZ1 ZNF518A CICP26 ENSG00000269890 HMGN2P19 NUP133 TAF5L BTNL10 ABCB10 HIST3H3 ENSG00000271399 URB2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAF5L on UCSC Golden Path with GeneCards custom track

Promoters for TAF5L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000021503 -53 2201 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207

Genomic Location for TAF5L Gene

Chromosome:
1
Start:
229,593,111 bp from pter
End:
229,626,047 bp from pter
Size:
32,937 bases
Orientation:
Minus strand

Genomic View for TAF5L Gene

Genes around TAF5L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF5L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF5L Gene

Proteins for TAF5L Gene

  • Protein details for TAF5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75529-TAF5L_HUMAN
    Recommended name:
    TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
    Protein Accession:
    O75529
    Secondary Accessions:
    • Q5TDI5
    • Q5TDI6
    • Q8IW31

    Protein attributes for TAF5L Gene

    Size:
    589 amino acids
    Molecular mass:
    66155 Da
    Quaternary structure:
    • The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.

    Alternative splice isoforms for TAF5L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAF5L Gene

Post-translational modifications for TAF5L Gene

  • Ubiquitination at posLast=293293 and posLast=481481
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TAF5L Gene

Domains & Families for TAF5L Gene

Gene Families for TAF5L Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TAF5L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75529

UniProtKB/Swiss-Prot:

TAF5L_HUMAN :
  • Belongs to the WD repeat TAF5 family.
Family:
  • Belongs to the WD repeat TAF5 family.
genes like me logo Genes that share domains with TAF5L: view

Function for TAF5L Gene

Molecular function for TAF5L Gene

UniProtKB/Swiss-Prot Function:
Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex.

Phenotypes From GWAS Catalog for TAF5L Gene

Gene Ontology (GO) - Molecular Function for TAF5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 9674425
GO:0003713 transcription coactivator activity IDA 11564863
GO:0004402 contributes_to histone acetyltransferase activity IDA 11564863
GO:0005515 protein binding IPI 25609649
genes like me logo Genes that share ontologies with TAF5L: view
genes like me logo Genes that share phenotypes with TAF5L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TAF5L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAF5L Gene

Localization for TAF5L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF5L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAF5L gene
Compartment Confidence
nucleus 5
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (3)
  • Cytoplasmic bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TAF5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 11564863
GO:0016607 nuclear speck IDA --
GO:0030914 STAGA complex IDA 11564863
GO:0033276 transcription factor TFTC complex IDA 10373431
GO:0036464 cytoplasmic ribonucleoprotein granule IDA --
genes like me logo Genes that share ontologies with TAF5L: view

Pathways & Interactions for TAF5L Gene

genes like me logo Genes that share pathways with TAF5L: view

Gene Ontology (GO) - Biological Process for TAF5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 9674425
GO:0043966 histone H3 acetylation IDA 11564863
genes like me logo Genes that share ontologies with TAF5L: view

No data available for SIGNOR curated interactions for TAF5L Gene

Drugs & Compounds for TAF5L Gene

No Compound Related Data Available

Transcripts for TAF5L Gene

Unigene Clusters for TAF5L Gene

TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TAF5L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TAF5L Gene

No ASD Table

Relevant External Links for TAF5L Gene

GeneLoc Exon Structure for
TAF5L
ECgene alternative splicing isoforms for
TAF5L

Expression for TAF5L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAF5L Gene

Protein differential expression in normal tissues from HIPED for TAF5L Gene

This gene is overexpressed in Lung (32.7), Bone marrow mesenchymal stem cell (16.2), and NK cells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TAF5L Gene



NURSA nuclear receptor signaling pathways regulating expression of TAF5L Gene:

TAF5L

SOURCE GeneReport for Unigene cluster for TAF5L Gene:

Hs.270621

Evidence on tissue expression from TISSUES for TAF5L Gene

  • Lung(4.3)
  • Nervous system(4.3)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with TAF5L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAF5L Gene

Orthologs for TAF5L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAF5L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF5L 33 34
  • 99.6 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 94 (a)
OneToMany
TAF5L 33
  • 86.7 (n)
-- 34
  • 80 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TAF5L 33 34
  • 93.38 (n)
mouse
(Mus musculus)
Mammalia Taf5l 33 16 34
  • 86.7 (n)
rat
(Rattus norvegicus)
Mammalia Taf5l 33
  • 86.19 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TAF5L 34
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAF5L 34
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAF5L 33 34
  • 82 (n)
lizard
(Anolis carolinensis)
Reptilia TAF5L 34
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia taf5l 33
  • 72.97 (n)
Str.15877 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.15175 33
zebrafish
(Danio rerio)
Actinopterygii taf5l 33 34
  • 66.27 (n)
wufi28g02 33
fruit fly
(Drosophila melanogaster)
Insecta CG4448 35
  • 25 (a)
wda 34
  • 22 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF5 34
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2457 34
  • 34 (a)
OneToOne
Species where no ortholog for TAF5L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAF5L Gene

ENSEMBL:
Gene Tree for TAF5L (if available)
TreeFam:
Gene Tree for TAF5L (if available)

Paralogs for TAF5L Gene

Paralogs for TAF5L Gene

(1) SIMAP similar genes for TAF5L Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TAF5L Gene

genes like me logo Genes that share paralogs with TAF5L: view

Variants for TAF5L Gene

Sequence variations from dbSNP and Humsavar for TAF5L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000024481 -- 229,620,845(+) TAGGA(C/T)GTCCT intron-variant
rs1000166517 -- 229,603,452(+) GTTTT(C/G)TGATT intron-variant
rs1000313113 -- 229,615,319(+) CCTGA(C/T)ATTGT intron-variant
rs1000349076 -- 229,620,635(+) GAGAG(C/T)TTATT intron-variant
rs1000455566 -- 229,609,147(+) TGGAG(C/T)ATATA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TAF5L Gene

Variant ID Type Subtype PubMed ID
esv22567 CNV loss 19812545
nsv549301 CNV gain+loss 21841781

Variation tolerance for TAF5L Gene

Residual Variation Intolerance Score: 11.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAF5L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAF5L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF5L Gene

Disorders for TAF5L Gene

Relevant External Links for TAF5L

Genetic Association Database (GAD)
TAF5L
Human Genome Epidemiology (HuGE) Navigator
TAF5L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAF5L

No disorders were found for TAF5L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAF5L Gene

Publications for TAF5L Gene

  1. The TAF5L gene on chromosome 1q42 is associated with type 1 diabetes in Russian affected patients. (PMID: 16206511) Chistiakov DA … Nosikov VV (Autoimmunity 2005) 3 22 45 60
  2. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PMID: 11124703) Stanchi F … Valle G (Yeast (Chichester, England) 2001) 2 3 4 60
  3. Histone-like TAFs within the PCAF histone acetylase complex. (PMID: 9674425) Ogryzko VV … Nakatani Y (Cell 1998) 2 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis. (PMID: 12601814) Cavusoglu N … Van Dorsselaer A (Proteomics 2003) 3 4 60

Products for TAF5L Gene

Sources for TAF5L Gene

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