TAF5L Gene
protein-coding GIFtS : 59
GC01M227795
TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa (Previous names: TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65 kD )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases & Descriptions for TAF5L
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases OTTHUMP00000037470 2 OTTHUMP00000037471 2 PAF65-beta 3 PAF65B 1 , 2 , 3
Descriptions PCAF associated factor 65 beta 2 PCAF-associated factor 65 beta 3 TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65 kD 1 , 2 TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 2 TAF5-like RNA polymerase II, p300/CBP-associated factor-associated factor, 65kDa 1
Search outside databases for aliases for TAF5L genePrevious GC identifers: GC01M228175 GC01M225423 GC01M226128 GC01M226690 GC01M226035
Summaries for TAF5L (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for TAF5L : The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes aprotein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylasecomplex, which is composed of more than 20 polypeptides some of which are TAFs, is required formyogenic transcription and differentiation. TAFs may participate in basal transcription, serve ascoactivators, function in promoter recognition or modify general transcription factors tofacilitate complex assembly and transcription initiation. The encoded protein is structurallysimilar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encodingdifferent isoforms have been identified for this gene. [provided by RefSeq] UniProtKB/Swiss-Prot: TAF5L_HUMAN, O75529 Function : Functions as a component of the PCAF complex. The PCAF complex is capable of efficientlyacetylating histones in a nucleosomal context. The PCAF complex could be considered as the humanversion of the yeast SAGA complex
Gene Wiki entry for TAF5L
Genomic Location for TAF5L
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the TAF5L gene Entrez Gene cytogenetic band: 1q42.13 Ensembl cytogenetic band: 1q42.13 HGNC cytogenetic band: 1q42.11-q42.3 TAF5L Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M227795:
(about GC identifiers )
Start:
227,795,481 bp from pter
End:
227,828,417 bp from pter
Size:
32,937 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000001.9 NT_004559.13 Proteins for TAF5L
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: TAF5L_HUMAN, O75529 (See
protein sequence )Recommended Name: TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDasubunit 5L Size : 589 amino acids; 66155 Da
Subunit : The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5,TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such asTADA2L/ADA2, TADA3L/ADA3 and SPT3. Component of the STAGA transcription coactivator-HAT complex,at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP andTAF9
Subcellular location : Nucleus
Secondary accessions : Q5TDI6 Q8IW31Alternative splicing : 2 isoforms : O75529-1 O75529-2
REFSEQ proteins (2 alternative transcripts):
NP_001020418.1 NP_055224.1 ENSEMBL proteins: ENSP00000258281 ENSP00000355636 ENSP00000355635 ENSP00000355634 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: TAF5L 1 Gene Ontology (GO) cellular component term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
About this table Antibodies for TAF5L: Assays for TAF5L:
Protein
Domains/ Families for TAF5L(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry O75529 ProtoNet protein and cluster: O75529
2 Blocks protein families : IPB001680 G-protein beta WD-40 repeat signature IPB007582 WD40 associated region in TFIID subunit UniProtKB/Swiss-Prot: TAF5L_HUMAN, O75529 Similarity : Belongs to the WD repeat TAF5 familySimilarity : Contains 6 WD repeats
Gene Function for TAF5L
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_014409 Applied Biosystems Silencer ® siRNAs for TAF5L Sigma-Aldrich siRNA for TAF5L Sigma-Aldrich shRNA for TAF5L Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001025247                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001025247                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001025247  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014409 UniProtKB/Swiss-Prot: TAF5L_HUMAN, O75529 Function : Functions as a component of the PCAF complex. The PCAF complex is capable of efficientlyacetylating histones in a nucleosomal context. The PCAF complex could be considered as the humanversion of the yeast SAGA complex
1 Gene Ontology (GO) molecular function term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0003700 transcription factor activity
TAS 9674425
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Pathways & Interactions for TAF5L
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for TAF5L (Your Favorite Gene powered by Ingenuity) 3 Interacting proteins for TAF5L (ENSP00000355636 3 ) via UniProtKB, MINT, and/or STRING About this table 2 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006355 regulation of transcription, DNA-dependent
IEA -- GO:0006366 transcription from RNA polymerase II promoter
TAS 9674425
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Drugs & Compounds for TAF5L (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Transcripts for TAF5L(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_014409 Sigma-Aldrich siRNA for TAF5L Sigma-Aldrich shRNA for TAF5L Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001025247 NM_014409
REFSEQ mRNAs for TAF5L gene (2 alternative transcripts): NM_001025247.1 NM_014409.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001025247 NM_014409
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001025247                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001025247                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001025247  
Additional cDNA sequence: AF069736.1 AJ009770.1 BC001569.1 BC041094.1
5 DOTS entries : DT.85102616 DT.434299 DT.91830511 DT.97817838 DT.91992393
24/98 AceView cDNA sequences (see all 98
):AA055381 AA055932 BE646579 AL041448 AV656444 AJ009770 D31141 AI356285 AA902634 AA524094 AI590283 AV660159 NM_014409 AA913241 BF431473 BC001569 AI479619 BM090850 AI251746 AI475890 AI075086 AA302683 AA557305 AW070931
highest scoring ESTs for TAF5L :AJ009770 AW105033 BC041094 BE646579 BM559120 AA055381 AA055932 AA282026 AA282682 AA302683
Unigene Cluster for TAF5L: TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa Hs.270621 [show with all ESTs ] Unigene Representative Sequence: NM_001025247 GeneLoc Exon Structure 4 Ensembl transcripts including schematic representations : ENST00000258281
ENST00000366676
ENST00000366675
ENST00000366674
Expression for TAF5L
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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TAF5L expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for TAF5L 1 / 2 / 3
5 probe-sets matching TAF5L gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GATGAACTTGSOURCE GeneReport for Unigene cluster: Hs.270621 Expression variation in blood from EXPOLDB for TAF5L
Orthologs for TAF5L
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for TAF5L gene from 5/9 species (see all 9
)
About this table Species with no ortholog for TAF5L ENSEMBL Gene Tree for TAF5L Paralogs for TAF5L (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for TAF5L gene TAF5 2
SNPs/Variants for TAF5L (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for TAF5L (up to first 250kb)
Disorders & Mutations for TAF5L
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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Genetic Association Database: TAF5L Human Genome Epidemiology Navigator: TAF5L (2 documents)
Medical News for TAF5L (Possibly Related Articles in
Doctor's Guide )
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--
Publications for TAF5L (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/16 PubMed articles for TAF5L gene (see all 16
): Characterization of 16 novel human genes showing high similarity to yeast sequences. (PubMed id 11124703) 2, 3, 4 Stanchi F....Valle G. (2001) Histone-like TAFs within the PCAF histone acetylase complex. (PubMed id 9674425) 2, 3, 4 Ogryzko V.V.... Nakatani Y. (1998) The TAF5L gene on chromosome 1q42 is associated with type 1 diabetes in Russian affected patients. (PubMed id 16206511) 1, 3, 6 Chistiakov D.A....Nosikov V.V. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis. (PubMed id 12601814) 3, 4 Cavusoglu N....Van Dorsselaer A. (2003) Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. (PubMed id 11564863) 3, 4 Martinez E....Roeder R.G. (2001) The TAFs in the HAT. (PubMed id 9674419) 3, 4 Struhl K. and Moqtaderi Z. (1998) Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression. (PubMed id 17476304) 3 Ravnskjaer K....Montminy M. (2007) Muscle cell survival mediated by the transcriptional coactivators p300 and PCAF displays different requirements for acetyltransferase activity. (PubMed id 16672693) 3 Kuninger D....Rotwein P. (2006) PCAF modulates PTEN activity. (PubMed id 16829519) 3 Okumura K....Furnari F.B. (2006)
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Genome Databases showing TAF5L
(According to
Entrez Gene ,
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AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing TAF5L
(According to HUGE )
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Specialized Databases showing TAF5L (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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