TAF5L Gene
protein-coding GIFtS: 55
GCID: GC01M229728
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|
TAF5-like RNA polymerase II, p300/CBP-associated factor...(Previous names: TAF5-like RNA polymerase II, p300/CBP-associated factor...)
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Aliases
for TAF5L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TAF5-Like RNA Polymerase II, P300/CBP-Associated Factor (PCAF)-AssociatedFactor, 65kDa1 2 | | TAF5-Like RNA Polymerase II, P300/CBP-Associated Factor (PCAF)-AssociatedFactor, 65 KD1 | | PAF65B1 2 3 | | PCAF Associated Factor 65 Beta2 | | PAF65-Beta1 | | TAF5-Like RNA Polymerase II P300/CBP-Associated Factor-Associated Factor 65 KDaSubunit 5L2 | | PCAF-Associated Factor 65 Beta2 3 | | |
Export aliases for TAF5L gene to outside databasesPrevious GC identifers: GC01M228175 GC01M225423 GC01M226128 GC01M226690 GC01M226035 GC01M227795 GC01M200221 |
Summaries
for TAF5L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TAF5L:
The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is acomponent of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participatein basal transcription, serve as coactivators, function in promoter recognition or modify general transcriptionfactors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar toone of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have beenidentified for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TAF5L_HUMAN, O75529Function: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histonesin a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex
Gene Wiki entry for TAF5L
|
Genomic Views
for TAF5L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TAF5L gene promoter:
E2F-4 E2F-3a E2F-5 Olf-1 E2F-2 GATA-2 E2F E2F-1 POU2F1 POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for TAF5L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAF5L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q42.13 Ensembl cytogenetic band: 1q42.13 HGNC cytogenetic band: 1q42.11-q42.3TAF5L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M229728: view genomic region
(about GC identifiers)
Start:
|
229,728,858 bp from pter |
End:
|
229,761,794 bp from pter |
Size:
|
32,937 bases |
Orientation:
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minus strand |
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Proteins
for TAF5L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TAF5L_HUMAN, O75529 (See
protein sequence)Recommended Name: TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L Size: 589 amino acids; 66155 Da
Subunit: The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L,TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3.Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L,SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9
Subcellular location: Nucleus
Secondary accessions: Q5TDI5 Q5TDI6 Q8IW31Alternative splicing: 2 isoforms: O75529-1 O75529-2 (May be due to an intron retention. No experimental confirmation available)Explore the universe of human proteins at neXtProt for TAF5L: NX_O75529
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O75529
TAF5L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001020418.1 NP_055224.1
ENSEMBL proteins: ENSP00000355636 ENSP00000355635 ENSP00000355634 ENSP00000258281
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TAF5L for ontologies About GeneDecksing
TAF5L Antibody Products:
Assay Products for TAF5L: |
Protein
Domains /
Families
for TAF5L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TAF5L for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry O75529ProtoNet protein and cluster: O75529 2 Blocks protein families: IPB001680 G-protein beta WD-40 repeat signature IPB007582 WD40 associated region in TFIID subunit
UniProtKB/Swiss-Prot: TAF5L_HUMAN, O75529Similarity: Belongs to the WD repeat TAF5 familySimilarity: Contains 6 WD repeats |
Function
for TAF5L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TAF5L_HUMAN, O75529Function: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histonesin a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAF5L (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF5L |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
TAF5L for ontologies About GeneDecksing
|
Pathways & Interactions
for TAF5L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Assembly of RNA Polymerase-II Initiation Complex | | | 2 | HIV Infection | | | 3 | Apoptotic Pathways in Synovial Fibroblasts | | | 4 | GPCR Pathway | | | 5 | Signal transduction Activin A signaling regulation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for TAF5L
5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TAF5L (see all 7)
1  GeneGo (Thomson Reuters) Pathway for TAF5L
1 
Kegg Pathway (Kegg details for TAF5L):
TAF5L for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAF5L
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/563 Interacting proteins for TAF5L (O755292, 3 ENSP000002582814) via UniProtKB, MINT, STRING, and/or I2D (see all 563)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
TAF5L for ontologies About GeneDecksing
|
Drugs & Compounds
for TAF5L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TAF5L
Search CenterWatch for drugs/clinical trials and news about TAF5L
|
Transcripts
for TAF5L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TAF5L gene (2 alternative transcripts): NM_001025247.1 NM_014409.3 Unigene Cluster for TAF5L: TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa Hs.270621 [show with all ESTs]Unigene Representative Sequence: NM_0010252475 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000366676 ENST00000366675(uc001htr.3) ENST00000477957 ENST00000366674
ENST00000258281(uc001htq.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAF5L (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAF5L (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TAF5L (NM_014409) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAF5L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAF5L |
Additional cDNA sequence: AF069736.1 AJ009770.1 BC001569.1 BC041094.1 5 DOTS entries: DT.85102616 DT.434299 DT.91830511 DT.97817838 DT.91992393 24/98 AceView cDNA sequences (see all 98): AI475890 AA902634 AI479619 BF431473 AA055932 AA913241 AA055381 AJ009770 AV660159 AV656444 BC001569 AI251746 AI590283 NM_014409 AA524094 D31141 BM090850 AI356285 BE646579 AL041448 BI496327 AA282682 BI060804 AA328301
GeneLoc Exon Structure
|
Expression
for TAF5L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TAF5L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATGAACTTG
About this image
See TAF5L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TAF5L
SOURCE GeneReport for Unigene cluster: Hs.270621
SABiosciences Custom PCR Arrays for TAF5L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAF5L
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF5L |
Orthologs
for TAF5L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TAF5L gene from 5/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TAF5L1 |
TAF5-like RNA polymerase II, p300/CBP-associated factor more |
82(n)
92.53(a) |
|
421538 XM_419579.3 XP_419579.2 |
lizard
(Anolis carolinensis) |
Reptilia |
TAF5L6 |
-- |
92(a) |
1 ↔ 1 |
1(222319026-222329616) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.151752 |
Xenopus laevis transcribed sequence with moderate similarity more |
75.87(n) |
|
CA982850.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufi28g022 |
wufi28g02 |
73.04(n) |
|
334055 BC056820.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG44483 |
microtubule severing |
25(a) |
|
94E9 -- |
ENSEMBL Gene Tree for TAF5L (if available)
TreeFam Gene Tree for TAF5L (if available) |
Paralogs
for TAF5L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TAF5L gene
- PHIP2 TAF52 BRWD12 BRWD32
1 SIMAP similar gene for TAF5L using alignment to 2 protein entries: TAF5L_HUMAN (see all proteins):TAF5
TAF5L for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TAF5L
PGOHUM00000237366
|
Genomic Variants
for TAF5L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TAF5L (229728858 - 229761794 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TAF5L
1 Indel: 71379 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAF5L |
|
Disorders
/ Diseases
for TAF5L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TAF5L for disorders About GeneDecksing
2  diseases for TAF5L: About MalaCardsretinal degeneration retinitis
Genetic Association Database (GAD): TAF5L
Human Genome Epidemiology (HuGE) Navigator: TAF5L (2 documents)
Export disorders for TAF5L gene to outside databases
|
Publications
for TAF5L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TAF5L gene, integrated from 9 sources (see all 32):
(articles sorted by number of sources associating them with TAF5L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of 16 novel human genes showing high similarity to yeast sequences. (PubMed id 11124703)1, 2, 3 Stanchi F.... Valle G. (2001)
- Histone-like TAFs within the PCAF histone acetylase complex. (PubMed id 9674425)1, 2, 3 Ogryzko V.V.... Nakatani Y. (1998)
- The TAF5L gene on chromosome 1q42 is associated with type 1 diabetes in Russian affected patients. (PubMed id 16206511)1, 4, 9 Chistiakov D.A....Nosikov V.V. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one- dimensional gel electrophoresis. (PubMed id 12601814)1, 2 Cavusoglu N.... van Dorsselaer A. (2003)
- Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage- binding factors in vivo. (PubMed id 11564863)1, 2 Martinez E.... Roeder R.G. (2001)
- The TAFs in the HAT. (PubMed id 9674419)1, 2 Struhl K. and Moqtaderi Z. (1998)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for TAF5L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TAF5L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TAF5L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TAF5L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TAF5L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TAF5L gene:
Search GeneIP for patents involving TAF5L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TAF5L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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