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TAF5L Gene

protein-coding   GIFtS: 57
GCID: GC01M229728

TAF5-Like RNA Polymerase II, P300/CBP-Associated Factor...

(Previous names: TAF5-like RNA polymerase II, p300/CBP-associated factor...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TAF5-Like RNA Polymerase II, P300/CBP-Associated Factor
(PCAF)-Associated Factor, 65kDa1 2
     PCAF-Associated Factor 65 Beta2 3
PCAF Associated Factor 65 Beta1 2     TAF5-Like RNA Polymerase II, P300/CBP-Associated Factor (PCAF)-Associated
Factor, 65 KD1
PAF65-beta2 3     TAF5-Like RNA Polymerase II P300/CBP-Associated Factor-Associated Factor
65 KDa Subunit 5L2
PAF65B2 3     

External Ids:    HGNC: 173041   Entrez Gene: 270972   Ensembl: ENSG000001358017   UniProtKB: O755293   

Export aliases for TAF5L gene to outside databases

Previous GC identifers: GC01M228175 GC01M225423 GC01M226128 GC01M226690 GC01M226035 GC01M227795 GC01M200221


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TAF5L Gene:
The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a
component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more
than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may
participate in basal transcription, serve as coactivators, function in promoter recognition or modify general
transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is
structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding
different isoforms have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for TAF5L Gene:
TAF5L (TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa) is a protein-coding gene. Diseases associated with TAF5L include retinal degeneration, and retinitis. GO annotations related to this gene include histone acetyltransferase activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TAF5.

UniProtKB/Swiss-Prot: TAF5L_HUMAN, O75529
Function: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating
histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA
complex

Gene Wiki entry for TAF5L Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_167186.2  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TAF5L gene promoter:
         E2F-4   E2F-3a   E2F-5   Olf-1   E2F-2   GATA-2   E2F   E2F-1   POU2F1   POU2F1a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TAF5L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAF5L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.13   Ensembl cytogenetic band:  1q42.13   HGNC cytogenetic band: 1q42.11-q42.3

TAF5L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAF5L gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M229728:  view genomic region     (about GC identifiers)

Start:
229,728,858 bp from pter      End:
229,761,794 bp from pter
Size:
32,937 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TAF5L_HUMAN, O75529 (See protein sequence)
Recommended Name: TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L  
Size: 589 amino acids; 66155 Da
Subunit: The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6,
TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and
SPT3. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L,
TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9
Secondary accessions: Q5TDI5 Q5TDI6 Q8IW31
Alternative splicing: 2 isoforms:  O75529-1   O75529-2   (May be due to an intron retention. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TAF5L: NX_O75529

Explore proteomics data for TAF5L at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys293, Lys481
  • Modification sites at PhosphoSitePlus

  • See TAF5L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001020418.1  NP_055224.1  

    ENSEMBL proteins: 
     ENSP00000355636   ENSP00000355635   ENSP00000355634   ENSP00000258281  
    Reactome Protein details: O75529

    TAF5L Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 6):
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry O75529

    ProtoNet protein and cluster: O75529

    2 Blocks protein domains:
    IPB001680 G-protein beta WD-40 repeat signature
    IPB007582 WD40 associated region in TFIID subunit


    UniProtKB/Swiss-Prot: TAF5L_HUMAN, O75529
    Similarity: Belongs to the WD repeat TAF5 family
    Similarity: Contains 6 WD repeats


    TAF5L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAF5L_HUMAN, O75529
    Function: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating
    histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA
    complex

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9674425
    GO:0003713transcription coactivator activity IDA11564863
    GO:0004402contributes to histone acetyltransferase activity IDA11564863
    GO:0005515protein binding ----
         
    TAF5L for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TAF5L
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    miRNA
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    miRTarBase miRNAs that target TAF5L:
    hsa-let-7c-5p (MIRT051804), hsa-mir-181b-5p (MIRT047279), hsa-let-7a-5p (MIRT052518), hsa-mir-155-5p (MIRT020642), hsa-mir-877-3p (MIRT037149), hsa-mir-98-5p (MIRT027492)

    Block miRNA regulation of human, mouse, rat TAF5L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TAF5L (see all 32):
    hsa-miR-124* hsa-miR-125a-5p hsa-miR-513a-5p hsa-miR-1260b hsa-miR-128 hsa-miR-374a hsa-miR-500a hsa-miR-373*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF5L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TAF5L_HUMAN, O75529: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0030914STAGA complex IDA11564863
    GO:0033276transcription factor TFTC complex IDA10373431

    TAF5L for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TAF5L About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Assembly of RNA Polymerase-II Initiation Complex
    Assembly of RNA Polymerase-II Initiation Complex0.91
    Basal transcription factors0.50
    Transcription of mRNA0.91
    Crosstalk Between CARM1 and ESRs0.39
    Protein Acetylation and Deacetylation0.51
    2RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34
    3Apoptotic Pathways in Synovial Fibroblasts
    Nuclear Receptor Activation by Vitamin-A0.57
    4GPCR Pathway
    Estrogen Pathway0.55
    5PEDF Induced Signaling
    Glucocorticoid Receptor Signaling0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TAF5L (see all 7)
        Nuclear Receptor Activation by Vitamin-A
    Protein Acetylation and Deacetylation
    Assembly of RNA Polymerase-II Initiation Complex
    Glucocorticoid Receptor Signaling
    Estrogen Pathway

    1 GeneGo (Thomson Reuters) Pathway for TAF5L
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 Reactome Pathway for TAF5L
        HATs acetylate histones


    2 Kegg Pathways  (Kegg details for TAF5L):
        Basal transcription factors
    Herpes simplex infection


    TAF5L for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TAF5L
    Interactions:

        Search GeneGlobe Interaction Network for TAF5L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TAF5L (O755292, 3 ENSP000002582814) via UniProtKB, MINT, STRING, and/or I2D (see all 627)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANXA7P200732, 3MINT-8248757 I2D: score=2 
    CDKN1AP389362, 3MINT-8252296 I2D: score=2 
    H2AFXP161042, 3MINT-8257977 I2D: score=2 
    TSC22D1Q157142, 3MINT-8275545 I2D: score=2 
    TTRP027662, 3MINT-8275971 I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006325chromatin organization TAS--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter TAS9674425
    GO:0043966histone H3 acetylation IDA11564863

    TAF5L for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TAF5L



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TAF5L gene (2 alternative transcripts): 
    NM_001025247.1  NM_014409.3  

    Unigene Cluster for TAF5L:

    TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
    Hs.270621  [show with all ESTs]
    Unigene Representative Sequence: NM_001025247
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366676 ENST00000366675(uc001htr.3) ENST00000477957 ENST00000366674
    ENST00000258281(uc001htq.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TAF5L (see all 32):
    hsa-miR-124* hsa-miR-125a-5p hsa-miR-513a-5p hsa-miR-1260b hsa-miR-128 hsa-miR-374a hsa-miR-500a hsa-miR-373*
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    Additional mRNA sequence: 

    AF069736.1 AJ009770.1 BC001569.1 BC041094.1 

    5 DOTS entries:

    DT.85102616  DT.434299  DT.91830511  DT.97817838  DT.91992393 

    Selected AceView cDNA sequences (see all 98):

    AA524094 BM090850 NM_014409 AA055932 AJ009770 BC001569 AA055381 D31141 
    AA902634 AI475890 AI479619 AL041448 AI590283 BE646579 AA913241 BF431473 
    AV660159 AI251746 AV656444 AI356285 AW105033 BE869039 AW070931 AA282682 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TAF5L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGAACTTG
    TAF5L Expression
    About this image

    TAF5L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TAF5L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.270621
        Custom PCR Arrays for TAF5L
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF5L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TAF5L gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Taf5l1 , 5 TAF5-like RNA polymerase II, p300/CBP-associated factor more1, 5 86.7(n)1
    93.38(a)1
      8 (72.31 cM)5
    1021621  NM_133966.21  NP_598727.11 
     1239963185 
    chicken
    (Gallus gallus)
    Aves TAF5L1 TAF5-like RNA polymerase II, p300/CBP-associated factor more 82(n)
    92.53(a)
      421538  XM_419579.4  XP_419579.2 
    lizard
    (Anolis carolinensis)
    Reptilia TAF5L6
    TAF5-like RNA polymerase II, p300/CBP-associated f...
    92(a)
    1 ↔ 1
    1(222315969-222329619)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.151752 Xenopus laevis transcribed sequence with moderate similarity more 75.87(n)    CA982850.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi28g022 wufi28g02 73.04(n)   334055  BC056820.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG44483 microtubule severing 25(a)   94E9   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TAF56
    Subunit (90 kDa) of TFIID and SAGA complexes, invo...
    24(a)
    1 → many
    II(616127-618523) YBR198C


    ENSEMBL Gene Tree for TAF5L (if available)
    TreeFam Gene Tree for TAF5L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TAF5L gene
    TAF52  WSB22  WSB12  WDSUB12  
    1 SIMAP similar gene for TAF5L using alignment to 2 protein entries:     TAF5L_HUMAN (see all proteins):
    TAF5

    TAF5L for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TAF5L
    PGOHUM00000237366


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TAF5L (see all 693)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1438597401,2
    --229728379(+) CAAAGC/TGCTGG 1 -- ds50010--------
    rs1486236021,2
    --229728484(+) CATAGC/TTTGAG 1 -- ds50010--------
    rs1913796001,2
    --229728734(+) CCTTCA/GTTGGG 1 -- ds50010--------
    rs731017631,2
    C,F--229728819(+) ACACTC/TACCCG 1 -- ds50012Minor allele frequency- T:0.13WA 120
    rs1424650781,2
    C--229728858(+) AACAC-/TTTTTT 1 -- ut310--------
    rs1159868841,2
    C,F--229729030(+) TCATTA/CGACTG 1 -- ut311Minor allele frequency- C:0.05WA 118
    rs586343161,2
    C--229729275(+) TCTCAA/GTCAAA 1 -- ut312Minor allele frequency- G:0.15WA 120
    rs1826414451,2
    --229729287(+) CCACCA/CACCCA 1 -- ut310--------
    rs1123370321,2
    C--229729334(+) CACCCG/AAAATT 1 -- ut312Minor allele frequency- A:0.04CSA WA 120
    rs2019091841,2
    --229729487(+) ATGTC-/AATAATAA 1 -- cds10--------

    HapMap Linkage Disequilibrium report for TAF5L (229728858 - 229761794 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TAF5L:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv22567CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TAF5L
    DNA2.0 Custom Variant and Variant Library Synthesis for TAF5L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    4 diseases for TAF5L:    About MalaCards
    retinal degeneration    retinitis    type 1 diabetes    herpes simplex


    TAF5L for disorders           About GeneDecksing

    Genetic Association Database (GAD): TAF5L
    Human Genome Epidemiology (HuGE) Navigator: TAF5L (2 documents)

    Export disorders for TAF5L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TAF5L gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with TAF5L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PubMed id 11124703)1, 2, 3 Stanchi F.... Valle G. (Yeast 2001)
    2. Histone-like TAFs within the PCAF histone acetylase complex. (PubMed id 9674425)1, 2, 3 Ogryzko V.V.... Nakatani Y. (Cell 1998)
    3. The TAF5L gene on chromosome 1q42 is associated with type 1 diabetes in Russian affected patients. (PubMed id 16206511)1, 4, 9 Chistiakov D.A....Nosikov V.V. (Autoimmunity 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one- dimensional gel electrophoresis. (PubMed id 12601814)1, 2 Cavusoglu N.... van Dorsselaer A. (Proteomics 2003)
    6. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage- binding factors in vivo. (PubMed id 11564863)1, 2 Martinez E.... Roeder R.G. (Mol. Cell. Biol. 2001)
    7. The TAFs in the HAT. (PubMed id 9674419)1, 2 Struhl K. and Moqtaderi Z. (Cell 1998)
    8. Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia. (PubMed id 23620142)1 Reiner A.P....Allayee H. (Hum. Mol. Genet. 2013)
    9. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 27097 HGNC: 17304 AceView: TAF5L Ensembl:ENSG00000135801 euGenes: HUgn27097
    ECgene: TAF5L Kegg: 27097 H-InvDB: TAF5L

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TAF5L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TAF5L gene:
    Search GeneIP for patents involving TAF5L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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