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Aliases for TAF5L Gene

Aliases for TAF5L Gene

  • TATA-Box Binding Protein Associated Factor 5 Like 2 3 5
  • TAF5-Like RNA Polymerase II, P300/CBP-Associated Factor (PCAF)-Associated Factor, 65kDa 2 3
  • PCAF-Associated Factor 65 Beta 3 4
  • PAF65-Beta 3 4
  • PAF65B 3 4
  • TAF5-Like RNA Polymerase II P300/CBP-Associated Factor-Associated Factor 65 KDa Subunit 5L 3
  • TAF5-Like RNA Polymerase II, P300/CBP-Associated Factor (PCAF)-Associated Factor, 65 KD 2
  • PCAF Associated Factor 65 Beta 2

External Ids for TAF5L Gene

Previous GeneCards Identifiers for TAF5L Gene

  • GC01M228175
  • GC01M225423
  • GC01M226128
  • GC01M226690
  • GC01M226035
  • GC01M227795
  • GC01M229728
  • GC01M200221

Summaries for TAF5L Gene

Entrez Gene Summary for TAF5L Gene

  • The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAF5L Gene

TAF5L (TATA-Box Binding Protein Associated Factor 5 Like) is a Protein Coding gene. Among its related pathways are Chromatin organization and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and histone acetyltransferase activity. An important paralog of this gene is TAF5.

UniProtKB/Swiss-Prot for TAF5L Gene

  • Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex.

Gene Wiki entry for TAF5L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF5L Gene

Genomics for TAF5L Gene

Regulatory Elements for TAF5L Gene

Enhancers for TAF5L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F228781 1.7 FANTOM5 Ensembl ENCODE 19.3 +843.0 842985 3.7 ARID4B FEZF1 ZNF2 ZNF302 ZNF416 FOS ZNF263 REST KAT8 MIER3 NUP133 CICP26 C1orf35 ENSG00000269890 PRSS38 TAF5L ABCB10 LOC100421842 ENSG00000233920 HMGB1P26
GH01F228646 1.6 FANTOM5 ENCODE 19.3 +978.0 978010 2.8 ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 ZNF302 ZNF416 ZNF207 FOS CICP26 NUP133 ENSG00000269890 C1orf35 HMGN2P19 HIST3H3 PRSS38 TAF5L ABCB10 LOC100421842
GH01F229248 1.5 FANTOM5 Ensembl ENCODE 19.9 +374.2 374246 6.8 ATF1 ARID4B GLI4 FEZF1 ZNF2 ZNF121 ZNF548 FOS DEK SP5 NUP133 ENSG00000269890 TAF5L ABCB10 URB2 ACTA1 HMGN2P19 LOC105373158 RAB4A CCSAP
GH01F229219 1.7 FANTOM5 Ensembl ENCODE 11.1 +404.1 404101 4.5 HDGF PKNOX1 ARID4B YBX1 FEZF1 DMAP1 ZNF2 YY1 ZNF302 ZNF416 NUP133 ENSG00000269890 LOC105373158 URB2 HMGN2P19 ENSG00000233920 LOC100421842 HMGB1P26 LINC01682 TAF5L
GH01F230152 1.6 FANTOM5 Ensembl ENCODE 11.1 -528.4 -528400 4.1 HDGF PKNOX1 ATF1 MLX ARID4B DMAP1 ZNF48 ELK1 ZNF548 MCM3 NUP133 TAF5L ENSG00000224407 ABCB10 HMGN2P19 URB2 GC01P230113 GC01M230200
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAF5L on UCSC Golden Path with GeneCards custom track

Promoters for TAF5L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000554640 -153 2801 HDGF CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207 KLF13

Genomic Location for TAF5L Gene

Chromosome:
1
Start:
229,593,111 bp from pter
End:
229,626,047 bp from pter
Size:
32,937 bases
Orientation:
Minus strand

Genomic View for TAF5L Gene

Genes around TAF5L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF5L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF5L Gene

Proteins for TAF5L Gene

  • Protein details for TAF5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75529-TAF5L_HUMAN
    Recommended name:
    TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
    Protein Accession:
    O75529
    Secondary Accessions:
    • Q5TDI5
    • Q5TDI6
    • Q8IW31

    Protein attributes for TAF5L Gene

    Size:
    589 amino acids
    Molecular mass:
    66155 Da
    Quaternary structure:
    • The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.

    Alternative splice isoforms for TAF5L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAF5L Gene

Post-translational modifications for TAF5L Gene

  • Ubiquitination at Lys 293 and Lys 481
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TAF5L Gene

Domains & Families for TAF5L Gene

Gene Families for TAF5L Gene

Suggested Antigen Peptide Sequences for TAF5L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75529

UniProtKB/Swiss-Prot:

TAF5L_HUMAN :
  • Belongs to the WD repeat TAF5 family.
  • Contains 6 WD repeats.
Family:
  • Belongs to the WD repeat TAF5 family.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with TAF5L: view

Function for TAF5L Gene

Molecular function for TAF5L Gene

UniProtKB/Swiss-Prot Function:
Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex.

Gene Ontology (GO) - Molecular Function for TAF5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 9674425
GO:0003713 transcription coactivator activity IDA 11564863
GO:0004402 contributes_to histone acetyltransferase activity IDA 11564863
GO:0005515 protein binding IPI 25609649
genes like me logo Genes that share ontologies with TAF5L: view
genes like me logo Genes that share phenotypes with TAF5L: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAF5L Gene

Localization for TAF5L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF5L Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAF5L gene
Compartment Confidence
nucleus 5
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TAF5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0030914 STAGA complex IDA 11564863
GO:0033276 transcription factor TFTC complex IDA 10373431
genes like me logo Genes that share ontologies with TAF5L: view

Pathways & Interactions for TAF5L Gene

genes like me logo Genes that share pathways with TAF5L: view

Gene Ontology (GO) - Biological Process for TAF5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 9674425
GO:0043966 histone H3 acetylation IDA 11564863
genes like me logo Genes that share ontologies with TAF5L: view

No data available for SIGNOR curated interactions for TAF5L Gene

Transcripts for TAF5L Gene

Unigene Clusters for TAF5L Gene

TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAF5L Gene

No ASD Table

Relevant External Links for TAF5L Gene

GeneLoc Exon Structure for
TAF5L
ECgene alternative splicing isoforms for
TAF5L

Expression for TAF5L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAF5L Gene

Protein differential expression in normal tissues from HIPED for TAF5L Gene

This gene is overexpressed in Lung (32.7), Bone marrow mesenchymal stem cell (16.2), and NK cells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TAF5L Gene



NURSA nuclear receptor signaling pathways regulating expression of TAF5L Gene:

TAF5L

SOURCE GeneReport for Unigene cluster for TAF5L Gene:

Hs.270621
genes like me logo Genes that share expression patterns with TAF5L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TAF5L Gene

Orthologs for TAF5L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAF5L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF5L 34 35
  • 99.6 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 94 (a)
OneToMany
TAF5L 34
  • 86.7 (n)
-- 35
  • 80 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TAF5L 34 35
  • 93.38 (n)
mouse
(Mus musculus)
Mammalia Taf5l 34 16 35
  • 86.7 (n)
rat
(Rattus norvegicus)
Mammalia Taf5l 34
  • 86.19 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TAF5L 35
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAF5L 35
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAF5L 34 35
  • 82 (n)
lizard
(Anolis carolinensis)
Reptilia TAF5L 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia taf5l 34
  • 72.97 (n)
Str.15877 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15175 34
zebrafish
(Danio rerio)
Actinopterygii taf5l 34 35
  • 66.27 (n)
wufi28g02 34
fruit fly
(Drosophila melanogaster)
Insecta CG4448 36
  • 25 (a)
wda 35
  • 22 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF5 35
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2457 35
  • 34 (a)
OneToOne
Species where no ortholog for TAF5L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAF5L Gene

ENSEMBL:
Gene Tree for TAF5L (if available)
TreeFam:
Gene Tree for TAF5L (if available)

Paralogs for TAF5L Gene

Paralogs for TAF5L Gene

(1) SIMAP similar genes for TAF5L Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TAF5L Gene

genes like me logo Genes that share paralogs with TAF5L: view

Variants for TAF5L Gene

Sequence variations from dbSNP and Humsavar for TAF5L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10218432 -- 229,595,047(+) CAGTG(A/G)CCCCG reference, synonymous-codon
rs10578192 -- 229,622,061(+) TCTAT(-/CTATCTAT)ACAGA intron-variant
rs10649912 -- 229,613,169(+) CAAGC(-/A)AAAAA intron-variant
rs10651663 -- 229,604,173(+) TAGCA(-/T/TT/TTT)TTTTT intron-variant
rs1077954 -- 229,626,572(-) AGCAG(C/G)TAGGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TAF5L Gene

Variant ID Type Subtype PubMed ID
esv22567 CNV loss 19812545
nsv549301 CNV gain+loss 21841781

Variation tolerance for TAF5L Gene

Residual Variation Intolerance Score: 11.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAF5L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAF5L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF5L Gene

Disorders for TAF5L Gene

Relevant External Links for TAF5L

Genetic Association Database (GAD)
TAF5L
Human Genome Epidemiology (HuGE) Navigator
TAF5L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAF5L

No disorders were found for TAF5L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAF5L Gene

Publications for TAF5L Gene

  1. The TAF5L gene on chromosome 1q42 is associated with type 1 diabetes in Russian affected patients. (PMID: 16206511) Chistiakov D.A. … Nosikov V.V. (Autoimmunity 2005) 3 22 46 64
  2. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PMID: 11124703) Stanchi F. … Valle G. (Yeast 2001) 2 3 4 64
  3. Histone-like TAFs within the PCAF histone acetylase complex. (PMID: 9674425) Ogryzko V.V. … Nakatani Y. (Cell 1998) 2 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one- dimensional gel electrophoresis. (PMID: 12601814) Cavusoglu N. … van Dorsselaer A. (Proteomics 2003) 3 4 64

Products for TAF5L Gene

Sources for TAF5L Gene

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