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Aliases for TAF5L Gene

Aliases for TAF5L Gene

  • TAF5-Like RNA Polymerase II, P300/CBP-Associated Factor (PCAF)-Associated Factor, 65kDa 2 3
  • PCAF Associated Factor 65 Beta 2 3
  • PCAF-Associated Factor 65 Beta 3 4
  • PAF65-Beta 3 4
  • PAF65B 3 4
  • TAF5-Like RNA Polymerase II P300/CBP-Associated Factor-Associated Factor 65 KDa Subunit 5L 3
  • TAF5-Like RNA Polymerase II, P300/CBP-Associated Factor (PCAF)-Associated Factor, 65 KD 2

External Ids for TAF5L Gene

Previous GeneCards Identifiers for TAF5L Gene

  • GC01M228175
  • GC01M225423
  • GC01M226128
  • GC01M226690
  • GC01M226035
  • GC01M227795
  • GC01M229728
  • GC01M200221

Summaries for TAF5L Gene

Entrez Gene Summary for TAF5L Gene

  • The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAF5L Gene

TAF5L (TAF5-Like RNA Polymerase II, P300/CBP-Associated Factor (PCAF)-Associated Factor, 65kDa) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and histone acetyltransferase activity. An important paralog of this gene is WDSUB1.

UniProtKB/Swiss-Prot for TAF5L Gene

  • Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex

Gene Wiki entry for TAF5L Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF5L Gene

Genomics for TAF5L Gene

Regulatory Elements for TAF5L Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TAF5L Gene

Start:
229,593,111 bp from pter
End:
229,626,047 bp from pter
Size:
32,937 bases
Orientation:
Minus strand

Genomic View for TAF5L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAF5L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF5L Gene

Proteins for TAF5L Gene

  • Protein details for TAF5L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75529-TAF5L_HUMAN
    Recommended name:
    TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
    Protein Accession:
    O75529
    Secondary Accessions:
    • Q5TDI5
    • Q5TDI6
    • Q8IW31

    Protein attributes for TAF5L Gene

    Size:
    589 amino acids
    Molecular mass:
    66155 Da
    Quaternary structure:
    • The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.

    Alternative splice isoforms for TAF5L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAF5L Gene

Proteomics data for TAF5L Gene at MOPED

Post-translational modifications for TAF5L Gene

  • Ubiquitination at Lys293 and Lys481
  • Modification sites at PhosphoSitePlus

Other Protein References for TAF5L Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TAF5L Gene

Domains for TAF5L Gene

Gene Families for TAF5L Gene

HGNC:
  • WDR :WD repeat domain containing

Suggested Antigen Peptide Sequences for TAF5L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75529

UniProtKB/Swiss-Prot:

TAF5L_HUMAN :
  • O75529
Family:
  • Belongs to the WD repeat TAF5 family.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with TAF5L: view

Function for TAF5L Gene

Molecular function for TAF5L Gene

UniProtKB/Swiss-Prot Function: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex

Gene Ontology (GO) - Molecular Function for TAF5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 9674425
GO:0003713 transcription coactivator activity IDA 11564863
GO:0004402 contributes_to histone acetyltransferase activity IDA 11564863
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TAF5L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAF5L

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TAF5L Gene

Localization for TAF5L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF5L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAF5L Gene COMPARTMENTS Subcellular localization image for TAF5L gene
Compartment Confidence
nucleus 5
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TAF5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0030914 STAGA complex IDA 11564863
GO:0033276 transcription factor TFTC complex IDA 10373431
genes like me logo Genes that share ontologies with TAF5L: view

Pathways for TAF5L Gene

genes like me logo Genes that share pathways with TAF5L: view

Gene Ontology (GO) - Biological Process for TAF5L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 9674425
GO:0043966 histone H3 acetylation IDA 11564863
genes like me logo Genes that share ontologies with TAF5L: view

Transcripts for TAF5L Gene

Unigene Clusters for TAF5L Gene

TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAF5L

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TAF5L

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAF5L Gene

No ASD Table

Relevant External Links for TAF5L Gene

GeneLoc Exon Structure for
TAF5L
ECgene alternative splicing isoforms for
TAF5L

Expression for TAF5L Gene

mRNA expression in normal human tissues for TAF5L Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAF5L Gene

SOURCE GeneReport for Unigene cluster for TAF5L Gene Hs.270621

genes like me logo Genes that share expressions with TAF5L: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TAF5L Gene

Orthologs for TAF5L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAF5L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF5L 35
  • 99.6 (n)
  • 100 (a)
TAF5L 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 94 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
TAF5L 35
  • 86.7 (n)
  • 93.21 (a)
dog
(Canis familiaris)
Mammalia TAF5L 35
  • 93.38 (n)
  • 98.98 (a)
TAF5L 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taf5l 35
  • 86.7 (n)
  • 93.38 (a)
Taf5l 16
Taf5l 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAF5L 36
  • 47 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAF5L 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Taf5l 35
  • 86.19 (n)
  • 91.59 (a)
chicken
(Gallus gallus)
Aves TAF5L 35
  • 82 (n)
  • 92.53 (a)
TAF5L 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAF5L 36
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15175 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15877 35
taf5l 35
  • 72.97 (n)
  • 81.77 (a)
zebrafish
(Danio rerio)
Actinopterygii taf5l 35
  • 66.27 (n)
  • 69.22 (a)
taf5l 36
  • 68 (a)
OneToOne
wufi28g02 35
fruit fly
(Drosophila melanogaster)
Insecta wda 36
  • 22 (a)
OneToOne
CG4448 37
  • 25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF5 36
  • 24 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2457 36
  • 34 (a)
OneToOne
Species with no ortholog for TAF5L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAF5L Gene

ENSEMBL:
Gene Tree for TAF5L (if available)
TreeFam:
Gene Tree for TAF5L (if available)

Paralogs for TAF5L Gene

Paralogs for TAF5L Gene

Selected SIMAP similar genes for TAF5L Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TAF5L Gene

genes like me logo Genes that share paralogs with TAF5L: view

Variants for TAF5L Gene

Sequence variations from dbSNP and Humsavar for TAF5L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs168347 -- 229,619,405(-) CCATT(C/T)TATTT intron-variant
rs348336 -- 229,598,220(-) tcatt(A/C)atgaa intron-variant
rs442099 -- 229,613,397(-) ATGTT(G/T)TTATG intron-variant
rs768578 -- 229,620,357(+) CCCGA(A/C)TCTAC intron-variant
rs997125 -- 229,622,805(+) AGACG(G/T)AGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAF5L Gene

Variant ID Type Subtype PubMed ID
esv22567 CNV Loss 19812545

Relevant External Links for TAF5L Gene

HapMap Linkage Disequilibrium report
TAF5L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF5L Gene

Disorders for TAF5L Gene

Relevant External Links for TAF5L

Genetic Association Database (GAD)
TAF5L
Human Genome Epidemiology (HuGE) Navigator
TAF5L
genes like me logo Genes that share disorders with TAF5L: view

No data available for UniProtKB/Swiss-Prot for TAF5L Gene

Publications for TAF5L Gene

  1. The TAF5L gene on chromosome 1q42 is associated with type 1 diabetes in Russian affected patients. (PMID: 16206511) Chistiakov D.A. … Nosikov V.V. (Autoimmunity 2005) 3 23 48
  2. Histone-like TAFs within the PCAF histone acetylase complex. (PMID: 9674425) Ogryzko V.V. … Nakatani Y. (Cell 1998) 2 3 4
  3. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PMID: 11124703) Stanchi F. … Valle G. (Yeast 2001) 2 3 4
  4. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage- binding factors in vivo. (PMID: 11564863) Martinez E. … Roeder R.G. (Mol. Cell. Biol. 2001) 3 4
  5. The TAFs in the HAT. (PMID: 9674419) Struhl K. … Moqtaderi Z. (Cell 1998) 3 4

Products for TAF5L Gene

Sources for TAF5L Gene

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