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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAF5 Gene

protein-coding   GIFtS: 57
GCID: GC10P105117

TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated...

(Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase...)
(Previous symbol: TAF2D)
 Explore 3 diseases affiliated with
TAF5 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TAF5    

Aliases
for TAF5 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
TAF5 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor,
100kDa1 2
     TAF(II)1002 3
TAF2D1 2 3 5     TAFII-1002 3
TAFII1001 2 3 5     TATA Box Binding Protein (TBP)-Associated Factor 2D2
TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, D, 100kD1 2     Transcription Initiation Factor TFIID 100 KD Subunit2
Transcription Initiation Factor TFIID 100 KDa Subunit2 3     Transcription Initiation Factor TFIID Subunit 52

External Ids:    HGNC: 115391   Entrez Gene: 68772   Ensembl: ENSG000001488357   OMIM: 6017875   UniProtKB: Q155423   

Export aliases for TAF5 gene to outside databases

Previous GC identifers: GC10P104020 GC10P104361 GC10P105258 GC10P104792 GC10P098758


Summaries
for TAF5 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TAF5:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that
coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the
polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a
channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily
conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as
coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex
assembly and transcription initiation. This gene encodes an integral subunit of TFIID associated with all
transcriptionally competent forms of that complex. This subunit interacts strongly with two TFIID subunits that show
similarity to histones H3 and H4, and it may participate in forming a nucleosome-like core in the TFIID complex.
(provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TAF5_HUMAN, Q15542
Function: TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and
TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase
transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone H3-related
TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently weaker
interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, and TAF12/TAFII20, but not TAF7/TAFII55, also
have been observed

Gene Wiki entry for TAF5


Genomic Views
for TAF5 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAF5 gene promoter:
         HOXA9   HOXA9B   AML1a   Pax-5   YY1   Meis-1b   SEF-1 (1)   c-Myb   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TAF5 promoter sequence
   Search SABiosciences Chromatin IP Primers for TAF5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAF5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24-q25.2   Ensembl cytogenetic band:  10q24.33   HGNC cytogenetic band: 10q24-q25.2

TAF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAF5 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P105117:  view genomic region     (about GC identifiers)

Start:
 105,127,724 bp from pter      End:
 105,148,822 bp from pter
Size:
 21,099 bases      Orientation:
 plus strand

Proteins
for TAF5 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TAF5_HUMAN, Q15542 (See protein sequence)
Recommended Name: Transcription initiation factor TFIID subunit 5  
Size: 800 amino acids; 86830 Da
Subunit: TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP
is not part of TFTC. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H/SPT3,
TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, GCN5L2/GCN5, TAF10 and TRRAP. Interacts with SV40 Large T antigen
Subcellular location: Nucleus
Sequence caution: Sequence=AAC50902.1; Type=Erroneous initiation; Sequence=BAD97335.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for TAF5:
2NXP (3D)    
Secondary accessions: A8K5B4 B2RMR0 B7ZKJ6 Q53EM4 Q5SYD5 Q86UZ7 Q9Y4K5
Alternative splicing: 2 isoforms:  Q15542-1   Q15542-2   

Explore the universe of human proteins at neXtProt for TAF5: NX_Q15542

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15542

    • TAF5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_008882.2  
    ENSEMBL proteins: 
     ENSP00000358854   ENSP00000311024  
    Reactome Protein details: Q15542
    Human Recombinant Protein Products: 
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    Uscn Proteins for TAF5

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005669transcription factor TFIID complex IDA14580349
    GO:0005730NOT nucleolus IDA--
    GO:0015629actin cytoskeleton IDA--


    TAF5 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TAF5

    Protein Domains /
    Families
    for TAF5 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TAF5 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q15542

    ProtoNet protein and cluster: Q15542

    3 Blocks protein families:
    IPB001680 G-protein beta WD-40 repeat signature
    IPB006594 Lissencephaly type-1-like homology motif
    IPB007582 WD40 associated region in TFIID subunit


    UniProtKB/Swiss-Prot: TAF5_HUMAN, Q15542
    Domain: Distinct domains of TAF5/TAFII100 are required for functional interaction with transcription factor TFIIFB
    (RAP30) and incorporation into the TFIID complex
    Similarity: Belongs to the WD repeat TAF5 family
    Similarity: Contains 1 LisH domain
    Similarity: Contains 6 WD repeats


    Function
    for TAF5 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TAF5_HUMAN, Q15542
    Function: TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and
    TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase
    transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone H3-related
    TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently weaker
    interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, and TAF12/TAFII20, but not TAF7/TAFII55, also
    have been observed

    miRNA
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    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate TAF5 (see all 18):
    hsa-miR-4272 hsa-miR-202 hsa-miR-449a hsa-miR-3692 hsa-miR-511 hsa-miR-548a-3p hsa-miR-548g hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmid: TAF5 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: TAF5
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for TAF5

    In Situ Assay
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    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IMP9045704
    GO:0004402contributes to histone acetyltransferase activity IDA10373431
    GO:0005515protein binding IPI9045704
    GO:0044212transcription regulatory region DNA binding IDA17996705


    TAF5 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for TAF5:
     Increased S DNA content  Synthetic lethal with Ras 


    Pathways & Interactions
    for TAF5 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Formation of RNA Pol II elongation complex
    8/13 pathways (see all 13)
    		RNA Polymerase II Pre-transcription Events0.72
    		RNA Polymerase II Promoter Escape0.40
    		Transcription of the HIV genome0.70
    		RNA Polymerase II Transcription Initiation0.40
    		RNA Polymerase II Transcription Initiation And Promoter Clearance0.40
    		Addition of the fourth nucleotide on the Nascent Transcript: Second Transition0.40
    		HIV-1 Transcription Initiation0.40
    		RNA Polymerase II Transcription Pre-Initiation And Promoter Opening0.40
    2Assembly of RNA Polymerase-II Initiation Complex
    		Assembly of RNA Polymerase-II Initiation Complex1.00
    		Basal transcription factors0.49
    		Transcription of mRNA0.91
    		Crosstalk Between CARM1 and ESRs0.32
    		Protein Acetylation and Deacetylation0.51
    3HIV Infection
    		HIV Infection1.00
    		Transcription Ligand-Dependent Transcription of Retinoid-Target genes0.28
    		Transcription_Ligand-Dependent Transcription of Retinoid-Target genes0.28
    4Late Phase of HIV Life Cycle
    		Late Phase of HIV Life Cycle1.00
    		HIV Life Cycle0.90
    5Transcription
    		Transcription1.00
    		RNA Polymerase II Transcription0.69

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    2 EMD Millipore Pathways for TAF5
        Histone modification
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TAF5 (see all 7)
        Nuclear Receptor Activation by Vitamin-A
    Protein Acetylation and Deacetylation
    Assembly of RNA Polymerase-II Initiation Complex
    Glucocorticoid Receptor Signaling
    Estrogen Pathway

    1 GeneGo (Thomson Reuters) Pathway for TAF5
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 BioSystems Pathway for TAF5 
        Eukaryotic Transcription Initiation

    5/19        Reactome Pathways for TAF5 (see all 19)
        Late Phase of HIV Life Cycle
    RNA Polymerase II Transcription
    RNA Polymerase II Transcription Initiation And Promoter Clearance
    Disease
    HIV Infection


    1         Kegg Pathway  (Kegg details for TAF5):
        Basal transcription factors


    TAF5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TAF5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/94 Interacting proteins for TAF5 (Q155422, 3 ENSP000003588544) via UniProtKB, MINT, STRING, and/or I2D (see all 94)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAF6P498482, 3, ENSP000003445374MINT-8088939 I2D: score=4 STRING: ENSP00000344537
    TAF9Q165943, ENSP000002178934I2D: score=3 STRING: ENSP00000370201 STRING: ENSP00000217893
    TAF3Q5VWG92, 3, ENSP000003402714MINT-8089065 I2D: score=1 STRING: ENSP00000340271
    TAF1P216753, ENSP000002760724I2D: score=4 STRING: ENSP00000276072
    CPSF1Q105703, ENSP000003393534I2D: score=3 STRING: ENSP00000339353
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006352DNA-dependent transcription, initiation IDA9603525
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--


    TAF5 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TAF5 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TAF5
    Search CenterWatch for drugs/clinical trials and news about TAF5 

    Transcripts
    for TAF5 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TAF5 gene: 
    NM_006951.3  

    Unigene Cluster for TAF5:

    TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
    Hs.96103  [show with all ESTs]
    Unigene Representative Sequence: NM_006951
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369839(uc001kwv.3 uc010qqq.2) ENST00000351396

    miRNA
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    hsa-miR-4272 hsa-miR-202 hsa-miR-449a hsa-miR-3692 hsa-miR-511 hsa-miR-548a-3p hsa-miR-548g hsa-miR-548x
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AK223615.1 AK291229.1 AL137373.1 BC052268.1 BC136340.1 BC136348.1 U75309.1 U80191.1 
    X95525.1 

    3 DOTS entries:

    DT.121272508  DT.442101  DT.121272568 

    24/41 AceView cDNA sequences (see all 41):

    CR610839 AA322411 AL524839 NM_006951 BX113246 AA977222 U80191 AA251738 
    BE503231 U75309 AA827897 BF056948 BC052268 AA761844 AW241461 BG533689 
    AI590915 AI269393 BE778147 BU158731 BU193699 AI452991 BG290312 AI470331 

    GeneLoc Exon Structure


    Expression
    for TAF5 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TAF5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTCTACTTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See TAF5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TAF5

    SOURCE GeneReport for Unigene cluster: Hs.96103
        SABiosciences Custom PCR Arrays for TAF5
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF5

    Orthologs
    for TAF5 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TAF5 gene from 9/35 species (see all 35)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TAF51 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa less 79.97(n)
    86.96(a)    		   423872  NM_001031235.1  NP_001026406.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TAF56
    		 --
    		 80(a)
    		 1 ↔ 1
    		 3(40630006-40643584)
    African clawed frog
    (Xenopus laevis)    		 Amphibia 480357692   -- 77.08(n)    48035769 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufc38g052 Transcribed sequence with weak similarity to protein refNP_008882.1 (H.sapiens) TATA box binding protein (TBP)-associated factor, RNA polymerase II, D, 100kD; TATA box binding protein (TBP)-associated factor, RNA polymerase II, [Homo sapiens] less 74.16(n)    CD754146.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Taf51 , 3 transcription initiation from Pol II
    promoter general RNA polymerase II
    transcription factor less3
    TBP-associated factor 51    		 41(a)
    (best of 3)3
    52.23(n)1
    44.77(a)1    		   47C33
    479001  NM_057609.51  NP_476957.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea taf-51 Protein TAF-5 47.92(n)
    36.35(a)    		   172552  NM_059768.4  NP_492169.2 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes TAF5(YBR198C)4
    TAF51    		 Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification less4
    Taf5p1    		 47.06(n)1
    37.62(a)1    		   2(618523-616127)4
    8524971, 4  NP_009757.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons TAF51 transcription initiation factor TFIID subunit D4 49.58(n)
    41.65(a)    		   832586  NM_122424.3  NP_197897.3 
    rice
    (Oryza sativa)    		 Liliopsida Os06g06495001 hypothetical protein 49.94(n)
    43.13(a)    		   4341679  NM_001064752.1  NP_001058217.1 


    ENSEMBL Gene Tree for TAF5 (if available)
    TreeFam Gene Tree for TAF5 (if available) 

    Paralogs
    for TAF5 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TAF5 gene
    PHIP2  BRWD12  TAF5L2  BRWD32  
    1 SIMAP similar gene for TAF5 using alignment to 1 protein entry:     TAF5_HUMAN:
    TAF5L

    TAF5 for paralogs           About GeneDecksing



    Genomic Variants
    for TAF5 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/326 NCBI SNPs in TAF5 are shown (see all 326)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1903425451,2
    		--105125857(+) TTGAAC/GGGCTG 1 -- us2k10--------
    rs108838561,2
    		C,F,H,--105125928(+) ACAAGG/TTTCCA 1 -- us2k115Minor allele frequency- T:0.01NS EA NA WA CSA 778
    rs127765441,2
    		C,--105126028(+) tgagaC/Tggagt 1 -- us2k12Minor allele frequency- T:0.08NA 122
    rs1828774381,2
    		--105126174(+) GCTAAA/GTTTTT 1 -- us2k10--------
    rs1874780371,2
    		--105126374(+) ATAACA/GTACAT 1 -- us2k10--------
    rs1917677421,2
    		--105126439(+) TCGTAC/TTGTCG 1 -- us2k10--------
    rs78931681,2
    		C,--105126446(+) gtcgcG/Tcaggc 1 -- us2k10--------
    rs1382764281,2
    		--105126529(+) CCTCCC/TGAGTA 1 -- us2k10--------
    rs1137757601,2
    		C,--105126583(+) GTATTG/TTTAGT 1 -- us2k10--------
    rs1496120021,2
    		--105126651(+) CGCCCA/GCCTCG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TAF5 (105127724 - 105148822 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TAF5: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAF5
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    Disorders / Diseases
    for TAF5 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TAF5 for disorders           About GeneDecksing

    OMIM gene information: 601787    OMIM disorders: --

    3 diseases for TAF5:    About MalaCards
    epidermodysplasia verruciformis    lissencephaly    immunodeficiency


    Export disorders for TAF5 gene to outside databases

    Publications
    for TAF5 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TAF5 gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with TAF5)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and analysis of two subunits of the human TFIID complex: hTAFII130 and hTAFII100. (PubMed id 8942982)1, 2, 3 Tanese N.... Admon A. (1996)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one- dimensional gel electrophoresis. (PubMed id 12601814)1, 2 Cavusoglu N.... van Dorsselaer A. (2003)
    4. Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction. (PubMed id 10373431)1, 2 Brand M.... Tora L. (1999)
    5. Specific interactions and potential functions of human TAFII100. (PubMed id 9045704)1, 2 Tao Y.... Roeder R.G. (1997)
    6. Distinct domains of hTAFII100 are required for functional interaction with transcription factor TFIIF beta (RAP30) and incorporation into the TFIID complex. (PubMed id 8758937)1, 2 Dubrovskaya V....Tora L. (1996)
    7. Localization of the gene (TAF2D) encoding the 100-kDa subunit (hTAFII100) of the human TFIID complex to chromosome 10 band q24-q25.2. (PubMed id 8884287)1, 3 Dubrovskaya V....Tora L. (1996)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. CTGC motifs within the HIV core promoter specify Tat-r esponsive pre-initiation complexes. (PubMed id 22834489)1 Wilhelm E....Bell B. (2012)
    10. Defective transcription initiation causes postnatal gr owth failure in a mouse model of nucleotide excision repair (NER) progeria. (PubMed id 22323595)1 Kamileri I....Garinis G.A. (2012)

    External Searches for TAF5 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
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    Genome Databases showing TAF5 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6877 HGNC: 11539 AceView: TAF5 Ensembl:ENSG00000148835 euGenes: HUgn6877
    ECgene: TAF5 Kegg: 6877 H-InvDB: TAF5

    Other Databases showing TAF5 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TAF5 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TAF5 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TAF5 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TAF5 gene:
    Search GeneIP for patents involving TAF5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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