Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TAF5 Gene

protein-coding   GIFtS: 59
GCID: GC10P105117

TAF5 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated...

(Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase...)
(Previous symbol: TAF2D)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
TAF5 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated
Factor, 100kDa1 2
     TAF(II)1002 3
TAF2D1 2 3 5     TAFII-1002 3
TAFII1002 3 5     TATA Box Binding Protein (TBP)-Associated Factor 2D2
TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, D,
100kD1 2
     Transcription Initiation Factor TFIID 100 KD Subunit2
Transcription Initiation Factor TFIID 100 KDa Subunit2 3     Transcription Initiation Factor TFIID Subunit 52

External Ids:    HGNC: 115391   Entrez Gene: 68772   Ensembl: ENSG000001488357   OMIM: 6017875   UniProtKB: Q155423   

Export aliases for TAF5 gene to outside databases

Previous GC identifers: GC10P104020 GC10P104361 GC10P105258 GC10P104792 GC10P098758


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TAF5 Gene:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein
that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to
position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription
complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a
group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal
transcription, serve as coactivators, function in promoter recognition or modify general transcription factors
(GTFs) to facilitate complex assembly and transcription initiation. This gene encodes an integral subunit of
TFIID associated with all transcriptionally competent forms of that complex. This subunit interacts strongly with
two TFIID subunits that show similarity to histones H3 and H4, and it may participate in forming a
nucleosome-like core in the TFIID complex. (provided by RefSeq, Jul 2008)

GeneCards Summary for TAF5 Gene:
TAF5 (TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa) is a protein-coding gene. GO annotations related to this gene include protein dimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is WSB2.

UniProtKB/Swiss-Prot: TAF5_HUMAN, Q15542
Function: TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and
TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase
transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone
H3-related TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently
weaker interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, and TAF12/TAFII20, but not
TAF7/TAFII55, also have been observed

Gene Wiki entry for TAF5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the TAF5 gene promoter:
         HOXA9   HOXA9B   AML1a   Pax-5   YY1   Meis-1b   SEF-1 (1)   c-Myb   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAF5 promoter sequence
   Search Chromatin IP Primers for TAF5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAF5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24-q25.2   Ensembl cytogenetic band:  10q24.33   HGNC cytogenetic band: 10q24-q25.2

TAF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAF5 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P105117:  view genomic region     (about GC identifiers)

Start:
105,127,724 bp from pter      End:
105,148,822 bp from pter
Size:
21,099 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TAF5_HUMAN, Q15542 (See protein sequence)
Recommended Name: Transcription initiation factor TFIID subunit 5  
Size: 800 amino acids; 86830 Da
Subunit: Homodimer. TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated
factors (TAFs). TBP is not part of TFTC. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L,
TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, GCN5L2/GCN5, TAF10 and TRRAP. Interacts with
SV40 Large T antigen
Sequence caution: Sequence=AAC50902.1; Type=Erroneous initiation; Sequence=BAD97335.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for TAF5:
2NXP (3D)    
Secondary accessions: A8K5B4 B2RMR0 B7ZKJ6 Q53EM4 Q5SYD5 Q86UZ7 Q9Y4K5
Alternative splicing: 2 isoforms:  Q15542-1   Q15542-2   

Explore the universe of human proteins at neXtProt for TAF5: NX_Q15542

Explore proteomics data for TAF5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TAF5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008882.2  
    ENSEMBL proteins: 
     ENSP00000358854   ENSP00000311024  
    Reactome Protein details: Q15542

    TAF5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TAF5
    GenScript Custom Purified and Recombinant Proteins Services for TAF5
    Novus Biologicals TAF5 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TAF5

     
    Search eBioscience for Proteins for TAF5 

     
    antibodies-online proteins for TAF5 (2 products) 

     
    Search antibodies-online for peptides for TAF5

    TAF5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TAF5
    OriGene Custom Antibody Services for TAF5
    Novus Biologicals TAF5 Antibodies
    Search for Antibodies for TAF5 at Abcam
    Cloud-Clone Corp. Antibodies for TAF5
    Search ThermoFisher Antibodies for TAF5
    antibodies-online antibodies for TAF5 (17 products) 

    TAF5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TAF5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TAF5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TAF5
    Cloud-Clone Corp. CLIAs for TAF5
    Search eBioscience for ELISAs for TAF5 
    antibodies-online kits for TAF5 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    WDR: WD repeat domain containing

    Selected InterPro protein domains (see all 7):
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q15542

    ProtoNet protein and cluster: Q15542

    3 Blocks protein domains:
    IPB001680 G-protein beta WD-40 repeat signature
    IPB006594 Lissencephaly type-1-like homology motif
    IPB007582 WD40 associated region in TFIID subunit


    UniProtKB/Swiss-Prot: TAF5_HUMAN, Q15542
    Domain: Distinct domains of TAF5/TAFII100 are required for functional interaction with transcription factor TFIIFB
    (RAP30) and incorporation into the TFIID complex
    Similarity: Belongs to the WD repeat TAF5 family
    Similarity: Contains 1 LisH domain
    Similarity: Contains 6 WD repeats


    Find genes that share domains with TAF5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAF5_HUMAN, Q15542
    Function: TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and
    TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase
    transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone
    H3-related TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently
    weaker interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, and TAF12/TAFII20, but not
    TAF7/TAFII55, also have been observed

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IMP9045704
    GO:0004402contributes to histone acetyltransferase activity IDA10373431
    GO:0005515protein binding IPI15899866
    GO:0044212transcription regulatory region DNA binding IDA17996705
         
    Find genes that share ontologies with TAF5           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TAF5:
     Increased S DNA content  Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TAF5

    miRNA
    Products:
        
    miRTarBase miRNAs that target TAF5:
    hsa-let-7a-5p (MIRT052580), hsa-let-7c-5p (MIRT051848), hsa-mir-98-5p (MIRT027509), hsa-mir-21-5p (MIRT030707)

    Block miRNA regulation of human, mouse, rat TAF5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TAF5 (see all 18):
    hsa-miR-4272 hsa-miR-202 hsa-miR-449a hsa-miR-3692 hsa-miR-511 hsa-miR-548a-3p hsa-miR-548g hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmidTAF5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TAF5
    Predesigned siRNA for gene silencing in human, mouse, rat TAF5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TAF5

    Clone
    Products:
         
    OriGene clones in human, mouse for TAF5 (see all 6)
    OriGene ORF clones in mouse, rat for TAF5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TAF5 (NM_006951)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAF5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAF5
    Addgene plasmids for TAF5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TAF5
    Browse ESI BIO Cell Lines and PureStem Progenitors for TAF5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TAF5_HUMAN, Q15542: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton4
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005669transcription factor TFIID complex IDA14580349
    GO:0005730NOT nucleolus IDA--
    GO:0015629actin cytoskeleton IDA--

    Find genes that share ontologies with TAF5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TAF5 About   (see all 11)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    RNA Polymerase II Pre-transcription Events0.73
    RNA Polymerase II HIV Promoter Escape0.67
    Transcription of the HIV genome0.71
    RNA Polymerase II Transcription Pre-Initiation And Promoter Opening0.67
    RNA Polymerase II Transcription Initiation And Promoter Clearance0.67
    RNA Polymerase II Transcription Initiation0.67
    RNA Polymerase II Promoter Escape0.67
    RNA Polymerase II Transcription0.60
    2Assembly of RNA Polymerase-II Initiation Complex
    Assembly of RNA Polymerase-II Initiation Complex0.91
    Basal transcription factors0.50
    Transcription of mRNA0.91
    Crosstalk Between CARM1 and ESRs0.39
    Protein Acetylation and Deacetylation0.51
    3HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    4Apoptotic Pathways in Synovial Fibroblasts
    Nuclear Receptor Activation by Vitamin-A0.57
    5GPCR Pathway
    Estrogen Pathway0.55


    Find genes that share SuperPaths with TAF5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TAF5 (see all 7)
        Nuclear Receptor Activation by Vitamin-A
    Protein Acetylation and Deacetylation
    Assembly of RNA Polymerase-II Initiation Complex
    Glucocorticoid Receptor Signaling
    Estrogen Pathway

    1 GeneGo (Thomson Reuters) Pathway for TAF5
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 BioSystems Pathway for TAF5
        Eukaryotic Transcription Initiation

    Selected Reactome Pathways for TAF5 (see all 8)
        RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
    RNA Polymerase II Transcription Initiation And Promoter Clearance
    RNA Polymerase II Promoter Escape
    RNA Polymerase II Transcription Initiation
    Transcription of the HIV genome


    2 Kegg Pathways  (Kegg details for TAF5):
        Basal transcription factors
    Herpes simplex infection

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TAF5
    Interactions:

        GeneGlobe Interaction Network for TAF5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TAF5 (Q155422, 3 ENSP000003588544) via UniProtKB, MINT, STRING, and/or I2D (see all 161)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAF6P498482, 3, ENSP000003445374MINT-8088939 I2D: score=4 STRING: ENSP00000344537
    TAF9Q165943, ENSP000002178934I2D: score=3 STRING: ENSP00000370201 STRING: ENSP00000217893
    TAF3Q5VWG92, 3, ENSP000003402714MINT-8089065 I2D: score=1 STRING: ENSP00000340271
    TAF1P216753, ENSP000002760724I2D: score=4 STRING: ENSP00000276072
    CPSF1Q105703, ENSP000003393534I2D: score=3 STRING: ENSP00000339353
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006352DNA-templated transcription, initiation IDA9603525
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--

    Find genes that share ontologies with TAF5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TAF5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TAF5 gene: 
    NM_006951.3  

    Unigene Cluster for TAF5:

    TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
    Hs.96103  [show with all ESTs]
    Unigene Representative Sequence: NM_006951
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369839(uc001kwv.3 uc010qqq.2) ENST00000351396
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TAF5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TAF5 (see all 18):
    hsa-miR-4272 hsa-miR-202 hsa-miR-449a hsa-miR-3692 hsa-miR-511 hsa-miR-548a-3p hsa-miR-548g hsa-miR-548x
    SwitchGear 3'UTR luciferase reporter plasmidTAF5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TAF5
    Predesigned siRNA for gene silencing in human, mouse, rat TAF5
    Clone
    Products:
         
    OriGene clones in human, mouse for TAF5 (see all 6)
    OriGene ORF clones in mouse, rat for TAF5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TAF5 (NM_006951)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAF5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAF5
    Addgene plasmids for TAF5 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TAF5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TAF5
      QuantiTect SYBR Green Assays in human, mouse, rat TAF5
      QuantiFast Probe-based Assays in human, mouse, rat TAF5

    Additional mRNA sequence: 

    AK223615.1 AK291229.1 AL137373.1 BC052268.1 BC136340.1 BC136348.1 U75309.1 U80191.1 
    X95525.1 

    3 DOTS entries:

    DT.121272508  DT.442101  DT.121272568 

    Selected AceView cDNA sequences (see all 41):

    CR610839 AA322411 AW241461 U75309 AL524839 BX113246 AA977222 AA251738 
    BC052268 BF056948 U80191 AA761844 BE503231 AA827897 NM_006951 X95525 
    BG290312 AI470331 AI452991 AI590915 BU158731 BU193699 AL515577 AI269393 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TAF5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTACTTCA
    TAF5 Expression
    About this image


    TAF5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    TAF5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TAF5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.96103
        Custom PCR Arrays for TAF5
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TAF5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TAF5
    QuantiTect SYBR Green Assays in human, mouse, rat TAF5
    QuantiFast Probe-based Assays in human, mouse, rat TAF5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TAF5 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Taf51 , 5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor less1, 5 91.33(n)1
    96.62(a)1
      19 (39.19 cM)5
    2261821  NM_177342.31  NP_796316.21 
     470677485 
    chicken
    (Gallus gallus)
    Aves TAF51 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa less 78.69(n)
    83.76(a)
      423872  NM_001031235.1  NP_001026406.1 
    lizard
    (Anolis carolinensis)
    Reptilia TAF56
    TAF5 RNA polymerase II, TATA box binding protein (...
    80(a)
    1 ↔ 1
    3(40630006-40643584)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480357692   -- 77.08(n)    48035769 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc38g052 Transcribed sequence with weak similarity to protein refNP_008882.1 (H.sapiens) TATA box binding protein (TBP)-associated factor, RNA polymerase II, D, 100kD; TATA box binding protein (TBP)-associated factor, RNA polymerase II, [Homo sapiens] less 74.16(n)    CD754146.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Taf51 , 3 transcription initiation from Pol II
    promoter general RNA polymerase II
    transcription factor less3
    TBP-associated factor 51
    41(a)
    (best of 3)3
    52.37(n)1
    45.56(a)1
      47C33
    479001  NM_057609.51  NP_476957.11 
    worm
    (Caenorhabditis elegans)
    Secernentea taf-51 taf-5 48.49(n)
    36.23(a)
      172552  NM_059768.5  NP_492169.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TAF5(YBR198C)4
    TAF51
    Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification less4
    TAF51
    42.13(n)1
    27.78(a)1
      2(618523-616127)4
    8524971, 4  NP_009757.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TAF51 TAF5 48.85(n)
    40.98(a)
      832586  NM_122424.3  NP_197897.3 
    rice
    (Oryza sativa)
    Liliopsida Os06g06495001 Os06g0649500 49.41(n)
    43.64(a)
      4341679  NM_001064752.1  NP_001058217.1 


    ENSEMBL Gene Tree for TAF5 (if available)
    TreeFam Gene Tree for TAF5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TAF5 gene
    WSB22  WSB12  TAF5L2  WDSUB12  
    1 SIMAP similar gene for TAF5 using alignment to 1 protein entry:     TAF5_HUMAN:
    TAF5L

    Find genes that share paralogs with TAF5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TAF5 (see all 430)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1810220631,2
    --98756915(+) ATTAAA/GTAACT 1 -- us2k10--------
    rs1855806361,2
    --98756929(+) TCCAGA/GTTATT 1 -- us2k10--------
    rs1903425451,2
    --105125857(+) TTGAAC/GGGCTG 1 -- us2k10--------
    rs108838561,2
    C,F,H--105125928(+) ACAAGG/TTTCCA 1 -- us2k115Minor allele frequency- T:0.01NS EA NA WA CSA 778
    rs127765441,2
    C,F--105126028(+) tgagaC/Tggagt 1 -- us2k12Minor allele frequency- T:0.08NA 122
    rs1828774381,2
    C--105126174(+) GCTAAA/GTTTTT 1 -- us2k10--------
    rs1874780371,2
    --105126374(+) ATAACA/GTACAT 1 -- us2k10--------
    rs1917677421,2
    --105126439(+) TCGTAC/TTGTCG 1 -- us2k10--------
    rs78931681,2
    C--105126446(+) gtcgcG/Tcaggc 1 -- us2k10--------
    rs1382764281,2
    --105126529(+) CCTCCC/TGAGTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TAF5 (105127724 - 105148822 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TAF5: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TAF5
    DNA2.0 Custom Variant and Variant Library Synthesis for TAF5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601787    OMIM disorders: --


    Find genes that share disorders with TAF5           About GenesLikeMe


    Export disorders for TAF5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TAF5 gene, integrated from 10 sources (see all 64):
    (articles sorted by number of sources associating them with TAF5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and analysis of two subunits of the human TFIID complex: hTAFII130 and hTAFII100. (PubMed id 8942982)1, 2, 3 Tanese N.... Admon A. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    2. Structural analysis and dimerization potential of the human TAF5 subunit of TFIID. (PubMed id 17227857)1, 2 Bhattacharya S....Jacobson R.H. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one- dimensional gel electrophoresis. (PubMed id 12601814)1, 2 Cavusoglu N.... van Dorsselaer A. (Proteomics 2003)
    5. Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction. (PubMed id 10373431)1, 2 Brand M.... Tora L. (J. Biol. Chem. 1999)
    6. Specific interactions and potential functions of human TAFII100. (PubMed id 9045704)1, 2 Tao Y.... Roeder R.G. (J. Biol. Chem. 1997)
    7. Distinct domains of hTAFII100 are required for functional interaction with transcription factor TFIIF beta (RAP30) and incorporation into the TFIID complex. (PubMed id 8758937)1, 2 Dubrovskaya V....Tora L. (EMBO J. 1996)
    8. Localization of the gene (TAF2D) encoding the 100-kDa subunit (hTAFII100) of the human TFIID complex to chromosome 10 band q24-q25.2. (PubMed id 8884287)1, 3 Dubrovskaya V....Tora L. (Genomics 1996)
    9. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    10. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PubMed id 23974872)1 Ripke S....Sullivan P.F. (Nat. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6877 HGNC: 11539 AceView: TAF5 Ensembl:ENSG00000148835 euGenes: HUgn6877
    ECgene: TAF5 Kegg: 6877 H-InvDB: TAF5

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TAF5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TAF5 gene:
    Search GeneIP for patents involving TAF5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TAF5   OriGene RNAi products in human, mouse, rat for TAF5  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TAF5  
     OriGene qSTAR qPCR primer pairs in human, mouse for TAF5   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TAF5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TAF5   OriGene Custom Protein Services for TAF5  

     
     
     Block miRNA regulation of human, mouse, rat TAF5 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TAF5
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAF5 Predesigned siRNA for gene silencing in human, mouse, rat TAF5
     QuantiFast Probe-based Assays in human, mouse, rat TAF5 QuantiTect SYBR Green Assays in human, mouse, rat TAF5
     Custom PCR Arrays for TAF5 Search Chromatin IP Primers for TAF5
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TAF5  GeneGlobe Interaction Network for TAF5
     Regulatory tfbs in TAF5 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TAF5 GenScript cDNA clones with any tag delivered in your preferred vector for TAF5
     GenScript Custom Assay Services for TAF5 GenScript Custom overexpressing Cell Line Services for TAF5
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TAF5
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TAF5 antibodies
     TAF5 proteins
     Search for Antibodies for TAF5 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for TAF5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TAF5
     Antibodies for TAF5
     ELISAs for TAF5
     CLIAs for TAF5



     Browse ESI BIO Cell Lines and PureStem Progenitors for TAF5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF5
     SwitchGear 3'UTR luciferase reporter plasmids for TAF5
     SwitchGear Promoter luciferase reporter plasmids for TAF5
     Search ThermoFisher Antibodies for TAF5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAF5
     Browse compounds at ApexBio
     Addgene plasmids for TAF5
      Search eBioscience for proteins for TAF5
      Search eBioscience for elisas for TAF5
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for TAF5
     antibodies-online antibodies for TAF5 (17 products)
     antibodies-online kits for TAF5 (4 products)
      Search antibodies-online for peptides for TAF5
     antibodies-online proteins for TAF5 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TAF5 gene at Home site.
    Version: 3.12.264 25 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4