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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAF5 Gene

protein-coding   GIFtS: 60
GCID: GC10P105117

TAF5 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated...

(Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase...)
(Previous symbol: TAF2D)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TAF5 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated
Factor, 100kDa1 2
     TAF(II)1002 3
TAF2D1 2 3 5     TAFII-1002 3
TAFII1002 3 5     TATA Box Binding Protein (TBP)-Associated Factor 2D2
TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, D,
100kD1 2
     Transcription Initiation Factor TFIID 100 KD Subunit2
Transcription Initiation Factor TFIID 100 KDa Subunit2 3     Transcription Initiation Factor TFIID Subunit 52

External Ids:    HGNC: 115391   Entrez Gene: 68772   Ensembl: ENSG000001488357   OMIM: 6017875   UniProtKB: Q155423   

Export aliases for TAF5 gene to outside databases

Previous GC identifers: GC10P104020 GC10P104361 GC10P105258 GC10P104792 GC10P098758


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TAF5 Gene:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein
that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to
position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription
complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a
group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal
transcription, serve as coactivators, function in promoter recognition or modify general transcription factors
(GTFs) to facilitate complex assembly and transcription initiation. This gene encodes an integral subunit of
TFIID associated with all transcriptionally competent forms of that complex. This subunit interacts strongly with
two TFIID subunits that show similarity to histones H3 and H4, and it may participate in forming a
nucleosome-like core in the TFIID complex. (provided by RefSeq, Jul 2008)

GeneCards Summary for TAF5 Gene: 
TAF5 (TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa) is a protein-coding gene. Diseases associated with TAF5 include epidermodysplasia verruciformis, and lissencephaly, and among its related super-pathways are RNA Polymerase II Pre-transcription Events and Assembly of RNA Polymerase-II Initiation Complex. GO annotations related to this gene include protein dimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is WDR61.

UniProtKB/Swiss-Prot: TAF5_HUMAN, Q15542
Function: TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and
TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase
transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone
H3-related TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently
weaker interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, and TAF12/TAFII20, but not
TAF7/TAFII55, also have been observed

Gene Wiki entry for TAF5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAF5 gene promoter:
         HOXA9   HOXA9B   AML1a   Pax-5   YY1   Meis-1b   SEF-1 (1)   c-Myb   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAF5 promoter sequence
   Search SABiosciences Chromatin IP Primers for TAF5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAF5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24-q25.2   Ensembl cytogenetic band:  10q24.33   HGNC cytogenetic band: 10q24-q25.2

TAF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAF5 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P105117:  view genomic region     (about GC identifiers)

Start:
105,127,724 bp from pter      End:
105,148,822 bp from pter
Size:
21,099 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TAF5_HUMAN, Q15542 (See protein sequence)
Recommended Name: Transcription initiation factor TFIID subunit 5  
Size: 800 amino acids; 86830 Da
Subunit: TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs).
TBP is not part of TFTC. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L,
SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, GCN5L2/GCN5, TAF10 and TRRAP. Interacts with SV40 Large
T antigen
Subcellular location: Nucleus
Sequence caution: Sequence=AAC50902.1; Type=Erroneous initiation; Sequence=BAD97335.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for TAF5:
2NXP (3D)    
Secondary accessions: A8K5B4 B2RMR0 B7ZKJ6 Q53EM4 Q5SYD5 Q86UZ7 Q9Y4K5
Alternative splicing: 2 isoforms:  Q15542-1   Q15542-2   

Explore the universe of human proteins at neXtProt for TAF5: NX_Q15542

Explore proteomics data for TAF5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15542

  • TAF5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TAF5 Protein Expression
    REFSEQ proteins: NP_008882.2  
    ENSEMBL proteins: 
     ENSP00000358854   ENSP00000311024  
    Reactome Protein details: Q15542
    Human Recombinant Protein Products for TAF5: 
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    Cloud-Clone Corp. Proteins for TAF5 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005669transcription factor TFIID complex IDA14580349
    GO:0005730NOT nucleolus IDA--
    GO:0015629actin cytoskeleton IDA--

    TAF5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    WDR: WD repeat domain containing

    5/7 InterPro protein domains (see all 7):
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q15542

    ProtoNet protein and cluster: Q15542

    3 Blocks protein domains:
    IPB001680 G-protein beta WD-40 repeat signature
    IPB006594 Lissencephaly type-1-like homology motif
    IPB007582 WD40 associated region in TFIID subunit


    UniProtKB/Swiss-Prot: TAF5_HUMAN, Q15542
    Domain: Distinct domains of TAF5/TAFII100 are required for functional interaction with transcription factor TFIIFB
    (RAP30) and incorporation into the TFIID complex
    Similarity: Belongs to the WD repeat TAF5 family
    Similarity: Contains 1 LisH domain
    Similarity: Contains 6 WD repeats


    TAF5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAF5_HUMAN, Q15542
    Function: TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and
    TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase
    transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone
    H3-related TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently
    weaker interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, and TAF12/TAFII20, but not
    TAF7/TAFII55, also have been observed

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IMP9045704
    GO:0004402contributes to histone acetyltransferase activity IDA10373431
    GO:0005515protein binding IPI15899866
    GO:0044212transcription regulatory region DNA binding IDA17996705
         
    TAF5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TAF5:
     Increased S DNA content  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TAF5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TAF5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TAF5 
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    SwitchGear 3'UTR luciferase reporter plasmidTAF5 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TAF5 About   (see all 12)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    RNA Polymerase II Pre-transcription Events0.72
    RNA Polymerase II Transcription Pre-Initiation And Promoter Opening0.67
    Transcription of the HIV genome0.70
    HIV Transcription Initiation0.67
    RNA Polymerase II Transcription Initiation And Promoter Clearance0.67
    RNA Polymerase II Transcription Initiation0.67
    RNA Polymerase II Promoter Escape0.67
    Eukaryotic Transcription Initiation0.60
    2Assembly of RNA Polymerase-II Initiation Complex
    Assembly of RNA Polymerase-II Initiation Complex0.91
    Basal transcription factors0.50
    Transcription of mRNA0.91
    Crosstalk Between CARM1 and ESRs0.39
    Protein Acetylation and Deacetylation0.51
    3HIV Life Cycle
    HIV Life Cycle0.92
    HIV Infection0.61
    Late Phase of HIV Life Cycle0.92
    4Transcription
    Transcription0.69
    RNA Polymerase II Transcription0.69
    5Apoptotic Pathways in Synovial Fibroblasts
    Nuclear Receptor Activation by Vitamin-A0.57

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for TAF5
        Histone modification
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TAF5 (see all 7)
        Nuclear Receptor Activation by Vitamin-A
    Protein Acetylation and Deacetylation
    Assembly of RNA Polymerase-II Initiation Complex
    Glucocorticoid Receptor Signaling
    Estrogen Pathway

    1 GeneGo (Thomson Reuters) Pathway for TAF5
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 BioSystems Pathway for TAF5
        Eukaryotic Transcription Initiation

    5/15        Reactome Pathways for TAF5 (see all 15)
        RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
    Late Phase of HIV Life Cycle
    RNA Polymerase II Transcription
    Transcription
    RNA Polymerase II Transcription Initiation And Promoter Clearance


    2         Kegg Pathways  (Kegg details for TAF5):
        Basal transcription factors
    Herpes simplex infection


    TAF5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TAF5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/95 Interacting proteins for TAF5 (Q155422, 3 ENSP000003588544) via UniProtKB, MINT, STRING, and/or I2D (see all 95)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TAF9Q165943, ENSP000002178934I2D: score=3 STRING: ENSP00000370201 STRING: ENSP00000217893
    TAF6P498482, 3, ENSP000003445374MINT-8088939 I2D: score=4 STRING: ENSP00000344537
    TAF3Q5VWG92, 3, ENSP000003402714MINT-8089065 I2D: score=1 STRING: ENSP00000340271
    TAF1P216753, ENSP000002760724I2D: score=4 STRING: ENSP00000276072
    AK6Q165943I2D: score=3 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006352DNA-dependent transcription, initiation IDA9603525
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--

    TAF5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TAF5

    Search CenterWatch for drugs/clinical trials and news about TAF5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TAF5 gene: 
    NM_006951.3  

    Unigene Cluster for TAF5:

    TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
    Hs.96103  [show with all ESTs]
    Unigene Representative Sequence: NM_006951
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369839(uc001kwv.3 uc010qqq.2) ENST00000351396
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK223615.1 AK291229.1 AL137373.1 BC052268.1 BC136340.1 BC136348.1 U75309.1 U80191.1 
    X95525.1 

    3 DOTS entries:

    DT.121272508  DT.442101  DT.121272568 

    24/41 AceView cDNA sequences (see all 41):

    AA827897 CR610839 AA761844 BF056948 BE503231 AA251738 AW241461 AA322411 
    BC052268 U80191 AL524839 NM_006951 AA977222 U75309 BX113246 AI269393 
    BE778147 AI470331 BU193699 BG533689 BU158731 X95525 BG290312 AL515577 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TAF5 expression in normal human tissues (normalized intensities)      TAF5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTACTTCA
    TAF5 Expression
    About this image


    TAF5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See TAF5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TAF5

    SOURCE GeneReport for Unigene cluster: Hs.96103
        SABiosciences Custom PCR Arrays for TAF5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TAF5 gene from 10/25 species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Taf51 , 5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated more1, 5 91.46(n)1
    96.87(a)1
      19 (39.19 cM)5
    2261821  NM_177342.31  NP_796316.21 
     470677485 
    chicken
    (Gallus gallus)
    Aves TAF51 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated more 79.97(n)
    86.96(a)
      423872  NM_001031235.1  NP_001026406.1 
    lizard
    (Anolis carolinensis)
    Reptilia TAF56
    Uncharacterized protein
    79(a)
    1 ↔ 1
    3(40630006-40643584)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480357692   -- 77.08(n)    48035769 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc38g052 Transcribed sequence with weak similarity to protein more 74.16(n)    CD754146.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Taf51 , 3 transcription initiation from Pol II
    promoter more3
    TBP-associated factor 51
    41(a)
    (best of 3)3
    52.23(n)1
    44.77(a)1
      47C33
    479001  NM_057609.51  NP_476957.11 
    worm
    (Caenorhabditis elegans)
    Secernentea taf-51 Protein TAF-5 47.92(n)
    36.35(a)
      172552  NM_059768.4  NP_492169.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TAF5(YBR198C)4
    TAF51
    Subunit (90 kDa) of TFIID and SAGA complexes, involved more4
    Taf5p1
    47.06(n)1
    37.62(a)1
      2(618523-616127)4
    8524971, 4  NP_009757.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TAF51 transcription initiation factor TFIID subunit D4 49.58(n)
    41.65(a)
      832586  NM_122424.3  NP_197897.3 
    rice
    (Oryza sativa)
    Liliopsida Os06g06495001 hypothetical protein 49.94(n)
    43.13(a)
      4341679  NM_001064752.1  NP_001058217.1 


    ENSEMBL Gene Tree for TAF5 (if available)
    TreeFam Gene Tree for TAF5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TAF5 gene
    WDR612  WSB22  WSB12  TAF5L2  
    1 SIMAP similar gene for TAF5 using alignment to 1 protein entry:     TAF5_HUMAN:
    TAF5L

    TAF5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/430 SNPs in TAF5 are shown (see all 430)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1810220631,2
    --98756915(+) ATTAAA/GTAACT 1 -- us2k10--------
    rs1855806361,2
    --98756929(+) TCCAGA/GTTATT 1 -- us2k10--------
    rs1903425451,2
    --105125857(+) TTGAAC/GGGCTG 1 -- us2k10--------
    rs108838561,2
    C,F,H--105125928(+) ACAAGG/TTTCCA 1 -- us2k115Minor allele frequency- T:0.01NS EA NA WA CSA 778
    rs127765441,2
    C,F--105126028(+) tgagaC/Tggagt 1 -- us2k12Minor allele frequency- T:0.08NA 122
    rs1828774381,2
    C--105126174(+) GCTAAA/GTTTTT 1 -- us2k10--------
    rs1874780371,2
    --105126374(+) ATAACA/GTACAT 1 -- us2k10--------
    rs1917677421,2
    --105126439(+) TCGTAC/TTGTCG 1 -- us2k10--------
    rs78931681,2
    C--105126446(+) gtcgcG/Tcaggc 1 -- us2k10--------
    rs1382764281,2
    --105126529(+) CCTCCC/TGAGTA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TAF5 (105127724 - 105148822 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TAF5: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TAF5
    DNA2.0 Custom Variant and Variant Library Synthesis for TAF5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601787    OMIM disorders: --

    3 diseases for TAF5:    About MalaCards
    epidermodysplasia verruciformis    lissencephaly    progeria


    TAF5 for disorders           About GeneDecksing


    Export disorders for TAF5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TAF5 gene, integrated from 9 sources (see all 62):
    (articles sorted by number of sources associating them with TAF5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and analysis of two subunits of the human TFIID complex: hTAFII130 and hTAFII100. (PubMed id 8942982)1, 2, 3 Tanese N.... Admon A. (1996)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one- dimensional gel electrophoresis. (PubMed id 12601814)1, 2 Cavusoglu N.... van Dorsselaer A. (2003)
    4. Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction. (PubMed id 10373431)1, 2 Brand M.... Tora L. (1999)
    5. Specific interactions and potential functions of human TAFII100. (PubMed id 9045704)1, 2 Tao Y.... Roeder R.G. (1997)
    6. Distinct domains of hTAFII100 are required for functional interaction with transcription factor TFIIF beta (RAP30) and incorporation into the TFIID complex. (PubMed id 8758937)1, 2 Dubrovskaya V....Tora L. (1996)
    7. Localization of the gene (TAF2D) encoding the 100-kDa subunit (hTAFII100) of the human TFIID complex to chromosome 10 band q24-q25.2. (PubMed id 8884287)1, 3 Dubrovskaya V....Tora L. (1996)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. CTGC motifs within the HIV core promoter specify Tat-r esponsive pre-initiation complexes. (PubMed id 22834489)1 Wilhelm E....Bell B. (2012)
    10. Defective transcription initiation causes postnatal gr owth failure in a mouse model of nucleotide excision repair (NER) progeria. (PubMed id 22323595)1 Kamileri I....Garinis G.A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6877 HGNC: 11539 AceView: TAF5 Ensembl:ENSG00000148835 euGenes: HUgn6877
    ECgene: TAF5 Kegg: 6877 H-InvDB: TAF5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TAF5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TAF5 gene:
    Search GeneIP for patents involving TAF5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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