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Aliases for TAF5 Gene

Aliases for TAF5 Gene

  • TATA-Box Binding Protein Associated Factor 5 2 3 5
  • TAF5 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 100kDa 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, D, 100kD 2 3
  • Transcription Initiation Factor TFIID 100 KDa Subunit 3 4
  • TAF(II)100 3 4
  • TAFII-100 3 4
  • TAFII100 3 4
  • TAF2D 3 4
  • Transcription Initiation Factor TFIID 100 KD Subunit 3
  • TATA Box Binding Protein (TBP)-Associated Factor 2D 3
  • Transcription Initiation Factor TFIID Subunit 5 3

External Ids for TAF5 Gene

Previous HGNC Symbols for TAF5 Gene

  • TAF2D

Previous GeneCards Identifiers for TAF5 Gene

  • GC10P104020
  • GC10P104361
  • GC10P105258
  • GC10P104792
  • GC10P105117
  • GC10P098758

Summaries for TAF5 Gene

Entrez Gene Summary for TAF5 Gene

  • Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes an integral subunit of TFIID associated with all transcriptionally competent forms of that complex. This subunit interacts strongly with two TFIID subunits that show similarity to histones H3 and H4, and it may participate in forming a nucleosome-like core in the TFIID complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

GeneCards Summary for TAF5 Gene

TAF5 (TATA-Box Binding Protein Associated Factor 5) is a Protein Coding gene. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and HIV Life Cycle. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is TAF5L.

UniProtKB/Swiss-Prot for TAF5 Gene

  • TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone H3-related TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently weaker interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, and TAF12/TAFII20, but not TAF7/TAFII55, also have been observed.

Gene Wiki entry for TAF5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF5 Gene

Genomics for TAF5 Gene

Regulatory Elements for TAF5 Gene

Enhancers for TAF5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F102772 1.1 FANTOM5 ENCODE 33 -589.4 -589355 11.7 PKNOX1 ZFP64 SIN3A YY1 ZNF121 GLIS2 FOS ZNF263 ZNF202 REST PDCD11 SFXN2 TAF5 ARL3 PPRC1 GBF1 LDB1 AS3MT INA BORCS7
GH10F102449 0.6 ENCODE 33 -914.8 -914773 8.0 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 PDCD11 TAF5 GBF1 RPEL1 SFXN2 PPRC1 ARL3 RPARP-AS1 INA CALHM2
GH10F103965 0.8 ENCODE 33 +600.4 600382 5.0 PKNOX1 ZFP64 SIN3A DMAP1 YY1 GLIS2 ELK1 ZNF263 ZNF202 REST PDCD11 ENSG00000260461 TAF5 STN1 LOC105378464 LOC101927523 SORCS3-AS1 INA RPEL1 MARCKSL1P1
GH10F104219 0.8 ENCODE 10.4 +852.4 852364 2.6 ZNF680 ZFP64 ZBTB11 ZNF140 MAX ZNF518A ZNF781 ZNF623 ZNF101 RARA CFAP43 INA ENSG00000260461 PDCD11 RPEL1 TAF5 MIR609
GH10F102853 0.4 ENCODE 10.4 -513.5 -513544 1.4 HDGF ARNT CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 GBF1 PDCD11 PPRC1 HPS6 LDB1 RPEL1 TAF5 ARL3 SFXN2 WBP1L
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TAF5 on UCSC Golden Path with GeneCards custom track

Promoters for TAF5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000360948 347 2201 HDGF PKNOX1 ARNT MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1

Genomic Location for TAF5 Gene

Chromosome:
10
Start:
103,367,953 bp from pter
End:
103,389,065 bp from pter
Size:
21,113 bases
Orientation:
Plus strand

Genomic View for TAF5 Gene

Genes around TAF5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF5 Gene

Proteins for TAF5 Gene

  • Protein details for TAF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15542-TAF5_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 5
    Protein Accession:
    Q15542
    Secondary Accessions:
    • A8K5B4
    • B2RMR0
    • B7ZKJ6
    • Q53EM4
    • Q5SYD5
    • Q86UZ7
    • Q9Y4K5

    Protein attributes for TAF5 Gene

    Size:
    800 amino acids
    Molecular mass:
    86830 Da
    Quaternary structure:
    • Homodimer. TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, GCN5L2/GCN5, TAF10 and TRRAP. Interacts with SV40 Large T antigen.
    SequenceCaution:
    • Sequence=AAC50902.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD97335.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TAF5 Gene

    Alternative splice isoforms for TAF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAF5 Gene

Post-translational modifications for TAF5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAF5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAF5 Gene

Domains & Families for TAF5 Gene

Gene Families for TAF5 Gene

Suggested Antigen Peptide Sequences for TAF5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15542

UniProtKB/Swiss-Prot:

TAF5_HUMAN :
  • Distinct domains of TAF5/TAFII100 are required for functional interaction with transcription factor TFIIFB (RAP30) and incorporation into the TFIID complex.
  • Belongs to the WD repeat TAF5 family.
  • Contains 6 WD repeats.
Domain:
  • Distinct domains of TAF5/TAFII100 are required for functional interaction with transcription factor TFIIFB (RAP30) and incorporation into the TFIID complex.
  • Contains 1 LisH domain.
Family:
  • Belongs to the WD repeat TAF5 family.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with TAF5: view

Function for TAF5 Gene

Molecular function for TAF5 Gene

UniProtKB/Swiss-Prot Function:
TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone H3-related TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently weaker interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, and TAF12/TAFII20, but not TAF7/TAFII55, also have been observed.

Gene Ontology (GO) - Molecular Function for TAF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding IMP 9045704
GO:0004402 contributes_to histone acetyltransferase activity IDA 10373431
GO:0005515 protein binding IPI 9045704
GO:0044212 transcription regulatory region DNA binding IDA 17996705
GO:0046983 protein dimerization activity IDA 17227857
genes like me logo Genes that share ontologies with TAF5: view
genes like me logo Genes that share phenotypes with TAF5: view

Animal Model Products

miRNA for TAF5 Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TAF5

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAF5 Gene

Localization for TAF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAF5 Gene COMPARTMENTS Subcellular localization image for TAF5 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TAF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 24289924
GO:0005634 nucleus IEA,IDA 15637059
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex IDA 9045704
GO:0005730 NOT nucleolus IDA 15637059
genes like me logo Genes that share ontologies with TAF5: view

Pathways & Interactions for TAF5 Gene

genes like me logo Genes that share pathways with TAF5: view

Gene Ontology (GO) - Biological Process for TAF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization IC 10373431
GO:0006351 transcription, DNA-templated IEA --
GO:0006352 DNA-templated transcription, initiation IDA 9603525
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with TAF5: view

No data available for SIGNOR curated interactions for TAF5 Gene

Transcripts for TAF5 Gene

mRNA/cDNA for TAF5 Gene

(2) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(41) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAF5 Gene

TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TAF5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAF5 Gene

No ASD Table

Relevant External Links for TAF5 Gene

GeneLoc Exon Structure for
TAF5
ECgene alternative splicing isoforms for
TAF5

Expression for TAF5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAF5 Gene

Protein differential expression in normal tissues from HIPED for TAF5 Gene

This gene is overexpressed in Liver, secretome (18.3) and Lymph node (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TAF5 Gene



Protein tissue co-expression partners for TAF5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TAF5 Gene:

TAF5

SOURCE GeneReport for Unigene cluster for TAF5 Gene:

Hs.96103
genes like me logo Genes that share expression patterns with TAF5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TAF5 Gene

Orthologs for TAF5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TAF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF5 34 35
  • 99.71 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 95 (a)
OneToMany
-- 35
  • 94 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TAF5 34 35
  • 94.08 (n)
cow
(Bos Taurus)
Mammalia TAF5 34 35
  • 93.92 (n)
rat
(Rattus norvegicus)
Mammalia Taf5 34
  • 91.85 (n)
mouse
(Mus musculus)
Mammalia Taf5 34 16 35
  • 91.33 (n)
oppossum
(Monodelphis domestica)
Mammalia TAF5 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAF5 34 35
  • 78.69 (n)
lizard
(Anolis carolinensis)
Reptilia TAF5 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia taf5 34
  • 75.41 (n)
zebrafish
(Danio rerio)
Actinopterygii taf5 34 35
  • 72.12 (n)
wufc38g05 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13815 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011678 34
  • 54.53 (n)
fruit fly
(Drosophila melanogaster)
Insecta Taf5 36 34 35
  • 52.37 (n)
CG4448 36
  • 40 (a)
can 36
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea taf-5 34
  • 48.49 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E23453g 34
  • 50.67 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL246C 34
  • 47.67 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF5 34 35 37
  • 42.13 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons TAF5 34
  • 48.85 (n)
rice
(Oryza sativa)
Liliopsida Os06g0649500 34
  • 49.41 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.7323 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2112 35
  • 52 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes taf5 34
  • 46.73 (n)
Species where no ortholog for TAF5 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for TAF5 Gene

ENSEMBL:
Gene Tree for TAF5 (if available)
TreeFam:
Gene Tree for TAF5 (if available)

Paralogs for TAF5 Gene

Paralogs for TAF5 Gene

(1) SIMAP similar genes for TAF5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TAF5: view

Variants for TAF5 Gene

Sequence variations from dbSNP and Humsavar for TAF5 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1052182 -- 103,368,365(+) AGGAG(A/G)CAGTG reference, missense
rs1052183 -- 103,378,337(+) GATTT(G/T)CGAAC reference, missense
rs1052184 -- 103,379,969(+) TTGGG(C/T)CGGAC reference, missense
rs10883856 -- 103,366,171(+) ACAAG(G/T)TTCCA upstream-variant-2KB
rs10883857 -- 103,367,830(+) GCTCG(G/T)TTTTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TAF5 Gene

Variant ID Type Subtype PubMed ID
dgv965n100 CNV gain 25217958
dgv966n100 CNV gain 25217958

Variation tolerance for TAF5 Gene

Residual Variation Intolerance Score: 19% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.97; 87.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAF5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF5 Gene

Disorders for TAF5 Gene

Relevant External Links for TAF5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAF5

No disorders were found for TAF5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAF5 Gene

Publications for TAF5 Gene

  1. Molecular cloning and analysis of two subunits of the human TFIID complex: hTAFII130 and hTAFII100. (PMID: 8942982) Tanese N. … Admon A. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4 64
  2. Structural analysis and dimerization potential of the human TAF5 subunit of TFIID. (PMID: 17227857) Bhattacharya S. … Jacobson R.H. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one- dimensional gel electrophoresis. (PMID: 12601814) Cavusoglu N. … van Dorsselaer A. (Proteomics 2003) 3 4 64
  5. Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction. (PMID: 10373431) Brand M. … Tora L. (J. Biol. Chem. 1999) 3 4 64

Products for TAF5 Gene

Sources for TAF5 Gene

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