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Aliases for TAF4B Gene

Aliases for TAF4B Gene

  • TAF4b RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 105kDa 2 3
  • TAFII105 3 4 6
  • TAF2C2 3 4 6
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, C2, 105kD 2 3
  • Transcription Initiation Factor TFIID 105 KDa Subunit 3 4
  • TATA Box Binding Protein (TBP)-Associated Factor 4B 2 3
  • TAF(II)105 3 4
  • Transcription Initiation Factor TFIID Subunit 4B 3
  • TAFII-105 4
  • SPGF13 3

External Ids for TAF4B Gene

Previous HGNC Symbols for TAF4B Gene

  • TAF2C2

Previous GeneCards Identifiers for TAF4B Gene

  • GC18P023722
  • GC18P023538
  • GC18P022037
  • GC18P022039
  • GC18P023806
  • GC18P020657

Summaries for TAF4B Gene

Entrez Gene Summary for TAF4B Gene

  • TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

GeneCards Summary for TAF4B Gene

TAF4B (TAF4b RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 105kDa) is a Protein Coding gene. Diseases associated with TAF4B include spermatogenic failure 13. Among its related pathways are Disease and Gene Expression. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and NF-kappaB binding. An important paralog of this gene is TAF4.

UniProtKB/Swiss-Prot for TAF4B Gene

  • Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis.

Gene Wiki entry for TAF4B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF4B Gene

Genomics for TAF4B Gene

Regulatory Elements for TAF4B Gene

Genomic Location for TAF4B Gene

Start:
26,225,936 bp from pter
End:
26,391,685 bp from pter
Size:
165,750 bases
Orientation:
Plus strand

Genomic View for TAF4B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAF4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF4B Gene

Proteins for TAF4B Gene

  • Protein details for TAF4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92750-TAF4B_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 4B
    Protein Accession:
    Q92750
    Secondary Accessions:
    • Q29YA4
    • Q29YA5

    Protein attributes for TAF4B Gene

    Size:
    862 amino acids
    Molecular mass:
    91091 Da
    Quaternary structure:
    • TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Heterodimerizes with TAF12/TFII20 via the C-terminal H2A-like histone-fold domain. This heterodimer forms a histone-like octamer with the TAF6/TAFII70-TAF9/TAFII31 heterodimer. Interacts with P65/RELA homodimers and P65/RELA-REL heterodimers. Interaction with POU2AF1, via its C-terminal activation domain, is required for octamer-dependent transcription.

    Alternative splice isoforms for TAF4B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAF4B Gene

Proteomics data for TAF4B Gene at MOPED

Post-translational modifications for TAF4B Gene

  • Under stimulation by forskolin, Isoform 1 is phosphorylated by protein kinase A (PKA).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAF4B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TAF4B Gene

Domains for TAF4B Gene

Protein Domains for TAF4B Gene

Suggested Antigen Peptide Sequences for TAF4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92750

UniProtKB/Swiss-Prot:

TAF4B_HUMAN :
  • Q92750
Domain:
  • Contains 1 histone-fold domain.
  • Contains 1 TAFH (NHR1) domain.
Family:
  • Belongs to the TAF4 family.
genes like me logo Genes that share domains with TAF4B: view

No data available for Gene Families for TAF4B Gene

Function for TAF4B Gene

Molecular function for TAF4B Gene

UniProtKB/Swiss-Prot Function: Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis.

Gene Ontology (GO) - Molecular Function for TAF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 15601843
GO:0003700 sequence-specific DNA binding transcription factor activity IEA --
GO:0046982 protein heterodimerization activity IEA --
GO:0051059 NF-kappaB binding IPI 10849440
genes like me logo Genes that share ontologies with TAF4B: view
genes like me logo Genes that share phenotypes with TAF4B: view

Animal Models for TAF4B Gene

MGI Knock Outs for TAF4B:

Animal Model Products

miRNA for TAF4B Gene

miRTarBase miRNAs that target TAF4B

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAF4B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TAF4B Gene

Localization for TAF4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF4B Gene

Nucleus. Cytoplasm. Note=Export into the cytoplasm is mediated by a CRM1-independent nuclear export pathway and not by phosphorylation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAF4B Gene COMPARTMENTS Subcellular localization image for TAF4B gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TAF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex IEA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TAF4B: view

Pathways for TAF4B Gene

genes like me logo Genes that share pathways with TAF4B: view

Pathways by source for TAF4B Gene

Gene Ontology (GO) - Biological Process for TAF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006352 DNA-templated transcription, initiation --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with TAF4B: view

Transcripts for TAF4B Gene

Unigene Clusters for TAF4B Gene

TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAF4B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TAF4B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAF4B Gene

No ASD Table

Relevant External Links for TAF4B Gene

GeneLoc Exon Structure for
TAF4B
ECgene alternative splicing isoforms for
TAF4B

Expression for TAF4B Gene

mRNA expression in normal human tissues for TAF4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TAF4B Gene

SOURCE GeneReport for Unigene cluster for TAF4B Gene Hs.369519

mRNA Expression by UniProt/SwissProt for TAF4B Gene

Q92750-TAF4B_HUMAN
Tissue specificity: Preferentially expressed in ovarian granulosa cells (at protein level). Highly expressed in B-cells.
genes like me logo Genes that share expressions with TAF4B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TAF4B Gene

Orthologs for TAF4B Gene

This gene was present in the common ancestor of animals.

Orthologs for TAF4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF4B 35
  • 99.47 (n)
  • 99.34 (a)
TAF4B 36
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAF4B 35
  • 87.5 (n)
  • 86.53 (a)
TAF4B 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAF4B 35
  • 90.16 (n)
  • 88.49 (a)
TAF4B 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taf4b 35
  • 85.02 (n)
  • 79.81 (a)
Taf4b 16
Taf4b 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAF4B 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAF4B 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1562997 35
  • 84.3 (n)
  • 77.62 (a)
chicken
(Gallus gallus)
Aves TAF4B 35
  • 67.68 (n)
  • 61.59 (a)
TAF4B 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAF4B 36
  • 46 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5624 35
zebrafish
(Danio rerio)
Actinopterygii taf4b 35
  • 55.44 (n)
  • 52.16 (a)
taf4b 36
  • 33 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Taf4 36
  • 20 (a)
OneToMany
Taf4 37
  • 47 (a)
worm
(Caenorhabditis elegans)
Secernentea taf-4 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8870 36
  • 37 (a)
OneToMany
Species with no ortholog for TAF4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TAF4B Gene

ENSEMBL:
Gene Tree for TAF4B (if available)
TreeFam:
Gene Tree for TAF4B (if available)

Paralogs for TAF4B Gene

Paralogs for TAF4B Gene

Selected SIMAP similar genes for TAF4B Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for TAF4B Gene

genes like me logo Genes that share paralogs with TAF4B: view

Variants for TAF4B Gene

Sequence variations from dbSNP and Humsavar for TAF4B Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs8820 -- 26,390,983(+) TTATA(G/T)TTCCT utr-variant-3-prime, nc-transcript-variant
rs13855 -- 26,390,753(+) TGAGG(A/G)GAATG utr-variant-3-prime, nc-transcript-variant
rs507613 -- 26,391,286(-) CTGTA(A/T)GTGAT utr-variant-3-prime, nc-transcript-variant
rs728203 -- 26,295,026(+) ggaaa(A/G)tattt intron-variant
rs936522 -- 26,344,879(+) gggta(C/T)ctagc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAF4B Gene

Variant ID Type Subtype PubMed ID
nsv909471 CNV Loss 21882294
nsv512522 CNV Loss 21212237
esv2459954 CNV Deletion 19546169
esv1519371 CNV Insertion 17803354

Relevant External Links for TAF4B Gene

HapMap Linkage Disequilibrium report
TAF4B
Human Gene Mutation Database (HGMD)
TAF4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF4B Gene

Disorders for TAF4B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TAF4B Gene including...

Search for TAF4B Gene in MalaCards »

UniProtKB/Swiss-Prot

TAF4B_HUMAN
  • Spermatogenic failure 13 (SPGF13) [MIM:615841]: A disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. {ECO:0000269 PubMed:24431330}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TAF4B

Genetic Association Database (GAD)
TAF4B
Human Genome Epidemiology (HuGE) Navigator
TAF4B
genes like me logo Genes that share disorders with TAF4B: view

Publications for TAF4B Gene

  1. A composite nuclear export signal in the TBP-associated factor TAFII105. (PMID: 11567023) Rashevsky-Finkel A. … Dikstein R. (J. Biol. Chem. 2001) 3 4 23
  2. Cyclic AMP-dependent modification of gonad-selective TAF(II)105 in a human ovarian granulosa cell line. (PMID: 16088961) Wu Y. … Li R. (J. Cell. Biochem. 2005) 3 4 23
  3. Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130. (PMID: 8858156) Dikstein R. … Tjian R. (Cell 1996) 2 3 4
  4. Specific interaction of TAFII105 with OCA-B is involved in activation of octamer-dependent transcription. (PMID: 10828057) Wolstein O. … Dikstein R. (J. Biol. Chem. 2000) 3 4 23
  5. Interaction of TAFII105 with selected p65/RelA dimers is associated with activation of subset of NF-kappa B genes. (PMID: 10849440) Yamit-Hezi A. … Dikstein R. (J. Biol. Chem. 2000) 2 3 4

Products for TAF4B Gene

Sources for TAF4B Gene

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