Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAF4B Gene

protein-coding   GIFtS: 59
GCID: GC18P023806

TAF4b RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated...

(Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase...)
(Previous symbol: TAF2C2)
Microbiology & Infectious Diseases Congress
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TAF4b RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated
Factor, 105kDa1 2
     Transcription Initiation Factor TFIID 105 KDa Subunit2 3
TAF2C21 2 3 5     TAF(II)1052 3
TAFII1052 3 5     TAFII-1052 3
TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, C2,
105kD1 2
     Transcription Initiation Factor TFIID 105 KD Subunit2
TATA Box Binding Protein (TBP)-Associated Factor 4B1 2     Transcription Initiation Factor TFIID Subunit 4B2

External Ids:    HGNC: 115381   Entrez Gene: 68752   Ensembl: ENSG000001413847   OMIM: 6016895   UniProtKB: Q927503   

Export aliases for TAF4B gene to outside databases

Previous GC identifers: GC18P023722 GC18P023538 GC18P022037 GC18P022039 GC18P020657


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TAF4B Gene:
TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein
complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell
type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells.
(provided by RefSeq, Sep 2011)

GeneCards Summary for TAF4B Gene: 
TAF4B (TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa) is a protein-coding gene. Diseases associated with TAF4B include huntington's disease, and among its related super-pathways are RNA Polymerase II Pre-transcription Events and HIV Life Cycle. GO annotations related to this gene include NF-kappaB binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TAF4.

UniProtKB/Swiss-Prot: TAF4B_HUMAN, Q92750
Function: Cell type-specific subunit of TFIID that may function as a gene-selective coactivator in certain cells.
TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various
activators and repressors. TAFII105 is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved
in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating
folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription

Gene Wiki entry for TAF4B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NT_010966.14  NC_018929.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAF4B gene promoter:
         Elk-1   Pax-5   HNF-4alpha2   IRF-1   HNF-4alpha1   HNF-1A   Max   AREB6   HNF-1   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TAF4B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAF4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q11.2   Ensembl cytogenetic band:  18q11.2   HGNC cytogenetic band: 18q11.1

TAF4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAF4B gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P023806:  view genomic region     (about GC identifiers)

Start:
23,805,900 bp from pter      End:
23,971,649 bp from pter
Size:
165,750 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TAF4B_HUMAN, Q92750 (See protein sequence)
Recommended Name: Transcription initiation factor TFIID subunit 4B  
Size: 862 amino acids; 91091 Da
Subunit: TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs).
Heterodimerizes with TAF12/TFII20 via the C-terminal H2A-like histone-fold domain. This heterodimer forms a
histone-like octamer with the TAF6/TAFII70-TAF9/TAFII31 heterodimer. Interacts with P65/RELA homodimers and
P65/RELA-REL heterodimers. Interaction with POU2AF1, via its C-terminal activation domain, is required for
octamer-dependent transcription
Subcellular location: Nucleus. Cytoplasm. Note=Export into the cytoplasm is mediated by a CRM1-independent nuclear
export pathway and not by phosphorylation
Secondary accessions: Q29YA4 Q29YA5
Alternative splicing: 2 isoforms:  Q92750-1   Q92750-2   (May be due to exon inclusion. No experimental confirmation available. Unphosphorylated form)

Explore the universe of human proteins at neXtProt for TAF4B: NX_Q92750

Explore proteomics data for TAF4B at MOPED 

Post-translational modifications:

  • UniProtKB: Under stimulation by forskolin, Isoform 1 is phosphorylated by protein kinase A (PKA)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92750

  • TAF4B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TAF4B Protein Expression
    REFSEQ proteins: NP_005631.1  
    ENSEMBL proteins: 
     ENSP00000269142   ENSP00000462980   ENSP00000389365   ENSP00000383314  
    Reactome Protein details: Q92750
    Human Recombinant Protein Products for TAF4B: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TAF4B
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TAF4B
    GenScript Custom Purified and Recombinant Proteins Services for TAF4B
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TAF4B 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS--
    GO:0005654nucleoplasm TAS--
    GO:0005669transcription factor TFIID complex IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--

    TAF4B for ontologies           About GeneDecksing



    TAF4B Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TAF4B
    GenScript Custom Superior Antibodies Services for TAF4B
    Novus Biologicals TAF4B Antibody
    Abcam antibodies for TAF4B
    Cloud-Clone Corp. Antibodies for TAF4B 
    Search ThermoFisher Antibodies for TAF4B
    LSBio Antibodies in human, mouse, rat for TAF4B 

    Assay Products for TAF4B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TAF4B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TAF4B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TAF4B 
    Cloud-Clone Corp. CLIAs for TAF4B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR007900 TAF4
     IPR003894 TAFH_NHR1
     IPR009072 Histone-fold

    Graphical View of Domain Structure for InterPro Entry Q92750

    ProtoNet protein and cluster: Q92750

    2 Blocks protein domains:
    IPB003894 TAF-like region
    IPB007900 Transcription initiation factor TFIID component TAF4


    UniProtKB/Swiss-Prot: TAF4B_HUMAN, Q92750
    Similarity: Belongs to the TAF4 family
    Similarity: Contains 1 histone-fold domain
    Similarity: Contains 1 TAFH (NHR1) domain


    TAF4B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAF4B_HUMAN, Q92750
    Function: Cell type-specific subunit of TFIID that may function as a gene-selective coactivator in certain cells.
    TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various
    activators and repressors. TAFII105 is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved
    in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating
    folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA15601843
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0046982protein heterodimerization activity IEA--
    GO:0051059NF-kappaB binding IPI10849440
         
    TAF4B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TAF4B:
     Decreased viability 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Taf4b):
     cellular  endocrine/exocrine gland  homeostasis/metabolism  mortality/aging  reproductive system 

    TAF4B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Taf4btm1Rtj for TAF4B

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TAF4B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TAF4B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TAF4B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TAF4B 

    miRNA
    Products:
        
    miRTarBase miRNAs that target TAF4B:
    hsa-mir-197 (MIRT004175)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TAF4B
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate TAF4B (see all 45):
    hsa-miR-2052 hsa-miR-3607-3p hsa-miR-300 hsa-miR-374a hsa-miR-30d hsa-miR-301a hsa-miR-449a hsa-miR-30a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TAF4B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAF4B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TAF4B
    Sirion Biotech Customized adenovirus for overexpression of TAF4B

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TAF4B (see all 7)
    OriGene ORF clones in mouse, rat for TAF4B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TAF4B (NM_005640)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAF4B
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TAF4B
    Sirion Biotech Customized lentivirus for stable overexpression of TAF4B 
                         Customized lentivirus expression plasmids for stable overexpression of TAF4B 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TAF4B
    Search LifeMap BioReagents cell lines for TAF4B
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF4B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TAF4B About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Formation of RNA Pol II elongation complex
    RNA Polymerase II Pre-transcription Events0.72
    RNA Polymerase II HIV Promoter Escape0.67
    Transcription of the HIV genome0.70
    RNA Polymerase II Transcription Pre-Initiation And Promoter Opening0.67
    RNA Polymerase II Transcription Initiation And Promoter Clearance0.67
    HIV Transcription Initiation0.67
    RNA Polymerase II Promoter Escape0.67
    RNA Polymerase II Transcription Initiation0.67
    2HIV Life Cycle
    HIV Life Cycle0.92
    HIV Infection0.61
    Late Phase of HIV Life Cycle0.92
    3Transcription
    Transcription0.69
    RNA Polymerase II Transcription0.69
    4Assembly of RNA Polymerase-II Initiation Complex
    Basal transcription factors0.50
    5Transcription Ligand-Dependent Transcription of Retinoid-Target genes
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes1.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TAF4B
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    1 GeneGo (Thomson Reuters) Pathway for TAF4B
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 BioSystems Pathway for TAF4B
        Validated targets of C-MYC transcriptional activation

    5/15        Reactome Pathways for TAF4B (see all 15)
        RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
    Late Phase of HIV Life Cycle
    RNA Polymerase II Transcription
    Transcription
    RNA Polymerase II Transcription Initiation And Promoter Clearance


    3         Kegg Pathways  (Kegg details for TAF4B):
        Basal transcription factors
    Huntington's disease
    Herpes simplex infection


    TAF4B for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TAF4B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/23 Interacting proteins for TAF4B (Q927503 ENSP000002691424) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GTF2A1P526553, ENSP000002981734I2D: score=1 STRING: ENSP00000298173
    TAF1P216753, ENSP000002760724I2D: score=1 STRING: ENSP00000276072
    TBPP202263, ENSP000002303544I2D: score=1 STRING: ENSP00000230354
    TAF12Q165143, ENSP000002639744I2D: score=2 STRING: ENSP00000263974
    RELAQ042063, ENSP000003842734I2D: score=2 STRING: ENSP00000384273
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006352DNA-dependent transcription, initiation NAS--
    GO:0006355regulation of transcription, DNA-dependent NAS--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--

    TAF4B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TAF4B

    Search CenterWatch for drugs/clinical trials and news about TAF4B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TAF4B gene: 
    NM_005640.1  

    Unigene Cluster for TAF4B:

    TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
    Hs.369519  [show with all ESTs]
    Unigene Representative Sequence: NM_005640
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000269142(uc002kvu.4 uc002kvs.4 uc002kvt.4) ENST00000578121
    ENST00000418698 ENST00000400466
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TAF4B
    8/45 QIAGEN miScript miRNA Assays for microRNAs that regulate TAF4B (see all 45):
    hsa-miR-2052 hsa-miR-3607-3p hsa-miR-300 hsa-miR-374a hsa-miR-30d hsa-miR-301a hsa-miR-449a hsa-miR-30a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TAF4B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAF4B
    Clone
    Products:
         
    OriGene clones in human, mouse for TAF4B (see all 7)
    OriGene ORF clones in mouse, rat for TAF4B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TAF4B (NM_005640)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAF4B
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TAF4B
    Sirion Biotech Customized lentivirus for stable overexpression of TAF4B 
                         Customized lentivirus expression plasmids for stable overexpression of TAF4B 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TAF4B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TAF4B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAF4B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAF4B

    Additional mRNA sequence: 

    AB234096.1 AK302593.1 AY888048.1 BC016360.1 BC032791.1 Y09321.1 

    3 DOTS entries:

    DT.442127  DT.101966187  DT.92420195 

    24/41 AceView cDNA sequences (see all 41):

    AA412656 BC016360 BX952116 AA721195 AA287057 BX952140 AA287145 AA458814 
    BI517527 BQ012407 Y09321 BM973282 AA976985 W77893 AW297262 BM853763 
    AA252384 W72761 BG217524 AL121204 BG213757 AA976562 AA252510 AA825151 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TAF4B expression in normal human tissues (normalized intensities)      TAF4B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGCACATT
    TAF4B Expression
    About this image


    TAF4B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Granulosa Cells Primary Follicle
             oocyte   
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Spermatogonial Stem Cells Seminiferous Tubules
     
     Gonad
             Spermatogonial Stem Cells Seminiferous Tubules

    See TAF4B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TAF4B

    SOURCE GeneReport for Unigene cluster: Hs.369519

    UniProtKB/Swiss-Prot: TAF4B_HUMAN, Q92750
    Tissue specificity: Preferentially expressed in ovarian granulosa cells (at protein level). Highly expressed in
    B-cells

        SABiosciences Custom PCR Arrays for TAF4B
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TAF4B
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TAF4B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAF4B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAF4B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF4B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TAF4B gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Taf4b1 , 5 TAF4B RNA polymerase II, TATA box binding protein (TBP)-associated more1, 5 85.02(n)1
    79.81(a)1
      18 (8.28 cM)5
    725041  NM_001100449.11  NP_001093919.11 
     147832455 
    chicken
    (Gallus gallus)
    Aves TAF4B1 TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated more 69.22(n)
    64.02(a)
      421086  XM_419170.3  XP_419170.3 
    lizard
    (Anolis carolinensis)
    Reptilia TAF4B6
    TAF4b RNA polymerase II, TATA box binding protein ...
    46(a)
    1 ↔ 1
    4(36730138-36808152)
    zebrafish
    (Danio rerio)
    Actinopterygii taf4b6
    TAF4b RNA polymerase II, TATA box binding protein ...
    34(a)
    1 ↔ 1
    20(18306330-18342154)
    fruit fly
    (Drosophila melanogaster)
    Insecta Taf43 regulation of transcription,
    DNA-dependent general more
    47(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea taf-46
    Protein TAF-4
    22(a)
    1 → many
    I(382833-388847)


    ENSEMBL Gene Tree for TAF4B (if available)
    TreeFam Gene Tree for TAF4B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TAF4B gene
    TAF42  
    2 SIMAP similar genes for TAF4B using alignment to 3 protein entries:     TAF4B_HUMAN (see all proteins):
    taf4b    TAF4

    TAF4B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TAF4B
    PGOHUM00000246038


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3260 SNPs in TAF4B are shown (see all 3260)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1447630131,2
    --23804503(+) AGTTTC/TTAAGT 1 -- us2k10--------
    rs1485406011,2
    --23804542(+) AATGCA/GTCTCT 1 -- us2k10--------
    rs99463861,2
    C,F--23804568(+) AGGAGG/ATGCTC 1 -- us2k12Minor allele frequency- A:0.15WA 120
    rs754122651,2
    C,F--23804578(+) CAATAA/CATTGA 1 -- us2k12Minor allele frequency- C:0.04WA 120
    rs578510151,2
    C,F--23804580(+) ATAAAT/GTGAGT 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1161198891,2
    F--23804584(+) ATTGAG/ATTTTT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs752013531,2
    F--23804599(+) CCCCAA/GCTCCA 1 -- us2k11Minor allele frequency- G:0.01EA 120
    rs1932925031,2
    --23804637(+) GATCAA/GGGAAT 1 -- us2k10--------
    rs1838452641,2
    --23804723(+) AGGTAA/GTAAGT 1 -- us2k10--------
    rs1418760451,2
    --23804884(+) AGCTTA/GTAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TAF4B (23805900 - 23971649 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TAF4B:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2459954CNV Deletion19546169
    esv1519371CNV Insertion17803354
    nsv909471CNV Loss21882294
    nsv512522CNV Loss21212237

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TAF4B
    DNA2.0 Custom Variant and Variant Library Synthesis for TAF4B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601689    OMIM disorders: --

    2 diseases for TAF4B:    About MalaCards
    huntington's disease    


    TAF4B for disorders           About GeneDecksing

    Genetic Association Database (GAD): TAF4B
    Human Genome Epidemiology (HuGE) Navigator: TAF4B (1 document)

    Export disorders for TAF4B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TAF4B gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with TAF4B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interaction of TAFII105 with selected p65/RelA dimers is associated with activation of subset of NF-kappa B genes. (PubMed id 10849440)1, 2, 3 Yamit-Hezi A.... Dikstein R. (2000)
    2. Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130. (PubMed id 8858156)1, 2, 3 Dikstein R.... Tjian R. (1996)
    3. A composite nuclear export signal in the TBP-associated factor TAFII105. (PubMed id 11567023)1, 2, 9 Rashevsky-Finkel A.... Dikstein R. (2001)
    4. Cyclic AMP-dependent modification of gonad-selective TAF(II)105 in a human ovarian granulosa cell line. (PubMed id 16088961)1, 2, 9 Wu Y.... Li R. (2005)
    5. Specific interaction of TAFII105 with OCA-B is involved in activation of octamer-dependent transcription. (PubMed id 10828057)1, 2, 9 Wolstein O.... Dikstein R. (2000)
    6. Genome-wide association study in premature ovarian fa ilure patients suggests ADAMTS19 as a possible candidate gene. (PubMed id 19508998)1, 4 Knauff E.A....Fauser B.C. (2009)
    7. Core promoter binding by histone-like TAF complexes. (PubMed id 15601843)1, 2 Shao H.... Dikstein R. (2005)
    8. TAF4/4b x TAF12 displays a unique mode of DNA binding and is required for core promoter function of a subset of genes. (PubMed id 19635797)1, 9 Gazit K....Dikstein R. (2009)
    9. Genome-wide association study identifies genetic risk underlying primary rhegmatogenous retinal detachment. (PubMed id 23585552)1 Kirin M....Mitry D. (2013)
    10. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6875 HGNC: 11538 AceView: TAF4B Ensembl:ENSG00000141384 euGenes: HUgn6875
    ECgene: TAF4B Kegg: 6875 H-InvDB: TAF4B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TAF4B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TAF4B gene:
    Search GeneIP for patents involving TAF4B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TAF4B  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for TAF4B  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TAF4B  
     OriGene qSTAR qPCR primer pairs in human, mouse for TAF4B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TAF4B   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TAF4B   OriGene Custom Protein Services for TAF4B  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TAF4B
     QIAGEN SeqTarget long-range PCR primers for resequencing TAF4B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAF4B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAF4B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAF4B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAF4B
     GenScript Custom Purified and Recombinant Proteins Services for TAF4B GenScript cDNA clones with any tag delivered in your preferred vector for TAF4B
     GenScript Custom Assay Services for TAF4B GenScript Custom Superior Antibodies Services for TAF4B
     GenScript Custom overexpressing Cell Line Services for TAF4B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TAF4B promoter
     Search Chromatin IP Primers for TAF4B
     RT2 qPCR Primer Assay in human, mouse, rat TAF4B
     GNC Network for TAF4B
     SABiosciences Custom PCR Arrays for TAF4B
     Search Tocris compounds for TAF4B
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TAF4B antibodies
     Antibodies for TAF4B
     See all of Abcam's Antibodies, Kits and Proteins for TAF4B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TAF4B
     Antibodies for TAF4B
     ELISAs for TAF4B
     CLIAs for TAF4B
     Search LifeMap BioReagents cell lines for TAF4B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF4B
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TAF4B
     Browse SwitchGear Promoter luciferase reporter plasmids for TAF4B
     Search ThermoFisher Antibodies for TAF4B
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TAF4B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TAF4B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TAF4B
    Customized:
     lentivirus for stable overexpression of TAF4B
     lentivirus expression plasmids for stable overexpression of TAF4B
     adenovirus for overexpression of TAF4B
     LSBio Antibodies in human, mouse, rat for TAF4B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TAF4B gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4