TAF4B Gene
protein-coding GIFtS : 54
GC18P022039
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa (Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase II, C2, 105kD )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbol: TAF2C2 )
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Aliases & Descriptions for TAF4B
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases TAF2C2 2 , 3 , 5 TAFII-105 3 TAFII105 1 , 2 , 3 , 5
Descriptions TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa 2 TAF4b RNA polymerase II, TATA box binding protein-associated factor, 105kDa 1 TATA box binding protein (TBP)-associated factor 4B 2 TATA box binding protein (TBP)-associated factor, RNA polymerase II, C2, 105kD 1 , 2 Transcription initiation factor TFIID 105 kDa subunit 3 transcription initiation factor TFIID 105 kD subunit 2
Search outside databases for aliases for TAF4B genePrevious GC identifers: GC18P023722 GC18P023538 GC18P022037
Summaries for TAF4B (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for TAF4B : TATA-binding protein associated factors (TAFs) participate, with TATA binding protein (TBP; MIM600075), in the formation of the TFIID protein complex (see MIM 313650), which is involved in theinitiation of gene transcription by RNA polymerase II (see MIM 180660).[supplied by OMIM] UniProtKB/Swiss-Prot: TAF4B_HUMAN, Q92750 Function : Cell type-specific subunit of TFIID that may function as a gene-selective coactivator incertain cells. TFIID is a multimeric protein complex that plays a central role in mediatingpromoter responses to various activators and repressors. TAFII105 is a transcriptional coactivatorof the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genesincluding TNFAIP3. May be involved in regulating folliculogenesis. Through interaction withOCBA/POU2AF1, acts as a coactivator of B cell-specific transcription
Gene Wiki entry for TAF4B
Genomic Location for TAF4B
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the TAF4B gene Entrez Gene cytogenetic band: 18q11.2 Ensembl cytogenetic band: 18q11.2 HGNC cytogenetic band: 18q11.1 TAF4B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure
GeneLoc location for GC18P022039:
(about GC identifiers )
Start:
22,060,407 bp from pter
End:
22,225,647 bp from pter
Size:
165,241 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000018.8 NT_010966.13 Proteins for TAF4B
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: TAF4B_HUMAN, Q92750 (See
protein sequence )Recommended Name: Transcription initiation factor TFIID subunit 4B Size : 862 amino acids; 91091 Da
Subunit : TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors(TAFs). Heterodimerizes with TAF12/TFII20 via the C-terminal H2A-like histone-fold domain. Thisheterodimer forms a histone-like octamer with the TAF6/TAFII70-TAF9/TAFII31 heterodimer. Interactswith P65/RELA homodimers and P65/RELA-REL heterodimers. Interaction with POU2AF1, via itsC-terminal activation domain, is required for octamer-dependent transcription
Subcellular location : Nucleus. Cytoplasm. Note=Export into the cytoplasm is mediated by aCRM1-independent nuclear export pathway and not by phosphorylation
Secondary accessions : Q29YA4 Q29YA5Alternative splicing : 2 isoforms : Q92750-1 Q92750-2
Post-translational modifications:
Under stimulation by forskolin, Isoform 1 is phosphorylated by protein kinase A (PKA)1
REFSEQ proteins: NP_005631.1 ENSEMBL proteins: ENSP00000383314 ENSP00000269142 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 4 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for TAF4B: Assays for TAF4B:
Protein
Domains/ Families for TAF4B(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q92750 ProtoNet protein and cluster: Q92750
2 Blocks protein families : IPB003894 TAF-like region IPB007900 Transcription initiation factor TFIID component TAF4 UniProtKB/Swiss-Prot: TAF4B_HUMAN, Q92750 Similarity : Belongs to the TAF4 familySimilarity : Contains 1 histone-fold domainSimilarity : Contains 1 TAFH (NHR1) domain
Gene Function for TAF4B
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
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RNAi Products ,
Clones , and
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_005640 Applied Biosystems Silencer ® siRNAs for TAF4B Sigma-Aldrich siRNA for TAF4B Sigma-Aldrich shRNA for TAF4B Explore Sigma-Aldrich super-pooled esiRNAs               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005640                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005640                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_005640  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005640 UniProtKB/Swiss-Prot: TAF4B_HUMAN, Q92750 Function : Cell type-specific subunit of TFIID that may function as a gene-selective coactivator incertain cells. TFIID is a multimeric protein complex that plays a central role in mediatingpromoter responses to various activators and repressors. TAFII105 is a transcriptional coactivatorof the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genesincluding TNFAIP3. May be involved in regulating folliculogenesis. Through interaction withOCBA/POU2AF1, acts as a coactivator of B cell-specific transcription
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Taf4b) :3 Gene Ontology (GO) molecular function terms (links to tree view) :
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Pathways & Interactions for TAF4B
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for TAF4B (Your Favorite Gene powered by Ingenuity) Gene Network CentralTM Interacting Genes and Proteins Network for TAF4B 5/49 Interacting proteins for TAF4B (ENSP00000269142 3 ) via UniProtKB, MINT, and/or STRING (see all 49
)About this table 4 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006350 transcription
IEA -- GO:0006355 regulation of transcription, DNA-dependent
NAS -- GO:0006367 transcription initiation from RNA polymerase II promoter
EXP 8946909 GO:0006368 RNA elongation from RNA polymerase II promoter
EXP 9405375
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Drugs & Compounds for TAF4B (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Transcripts for TAF4B(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_005640 Sigma-Aldrich siRNA for TAF4B Sigma-Aldrich shRNA for TAF4B Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_005640
REFSEQ mRNAs for TAF4B gene: NM_005640.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005640
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005640                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005640                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_005640  
Additional cDNA sequence: AB234096.1 AK302593.1 AY888048.1 BC016360.1 BC032791.1 Y09321.1
3 DOTS entries : DT.442127 DT.101966187 DT.92420195
24/41 AceView cDNA sequences (see all 41
):AA287145 BC016360 AA412656 AA458814 AA721195 BX952140 BX952116 AA287057 W77893 BC032791 BM973282 R24013 AA825151 AL121204 AA976985 BM853763 W72761 BQ012407 BG213757 Y09321 AA252510 AA976562 BG217524 AA252384
highest scoring ESTs for TAF4B :Y09321 AA252384 AA252510 AA287145 AA412656 AA458814 AA825151 AA976562 AA976985 AL079947
Unigene Cluster for TAF4B: TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa Hs.369519 [show with all ESTs ] Unigene Representative Sequence: NM_005640 GeneLoc Exon Structure 2 Ensembl transcripts including schematic representations : ENST00000400466
ENST00000269142
Expression for TAF4B
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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TAF4B expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for TAF4B 1 / 2 / 3
6 probe-sets matching TAF4B gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TTGGCACATTSOURCE GeneReport for Unigene cluster: Hs.369519 Expression variation in blood from EXPOLDB for TAF4B
UniProtKB/Swiss-Prot: TAF4B_HUMAN, Q92750 Tissue specificity : Preferentially expressed in ovarian granulosa cells (at protein level). Highlyexpressed in B cells
Orthologs for TAF4B
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for TAF4B gene from 5/8 species (see all 8
)
About this table Species with no ortholog for TAF4B ENSEMBL Gene Tree for TAF4B Paralogs for TAF4B (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for TAF4B gene TAF4 2
SNPs/Variants for TAF4B (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for TAF4B (up to first 250kb)
Disorders & Mutations for TAF4B
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 601689
Medical News for TAF4B (Possibly Related Articles in
Doctor's Guide )
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--
Publications for TAF4B (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/15 PubMed articles for TAF4B gene (see all 15
): Interaction of TAFII105 with selected p65/RelA dimers is associated with activation of subset of NF-kappa B genes. (PubMed id 10849440) 2, 3, 4 Yamit-Hezi A....Dikstein R. (2000) Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130. (PubMed id 8858156) 2, 3, 4 Dikstein R.... Tjian R. (1996) A composite nuclear export signal in the TBP-associated factor TAFII105. (PubMed id 11567023) 1, 3, 4 Rashevsky-Finkel A.... Dikstein R. (2001) Cyclic AMP-dependent modification of gonad-selective TAF(II)105 in a human ovarian granulosa cell line. (PubMed id 16088961) 1, 3, 4 Wu Y.... Li R. (2005) Specific interaction of TAFII105 with OCA-B is involved in activation of octamer-dependent transcription. (PubMed id 10828057) 1, 3, 4 Wolstein O.... Dikstein R. (2000) Core promoter binding by histone-like TAF complexes. (PubMed id 15601843) 3, 4 Shao H.... Dikstein R. (2005) Structural changes in TAF4b-TFIID correlate with promoter selectivity. (PubMed id 18206971) 3 Liu W.L....Tjian R. (2008) Expression of the TAF4b gene is induced by MYC through a non-canonical, but not canonical, E-box which contributes to its specific response to MYC. (PubMed id 19020761) 3 Teye K....Tsuneoka M. (2008) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002) TAFII105 mediates activation of anti-apoptotic genes by NF-kappaB. (PubMed id 9724652) 3 Yamit-Hezi A. and Dikstein R. (1998)
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Genome Databases showing TAF4B
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing TAF4B
(According to HUGE )
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Specialized Databases showing TAF4B (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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