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TAF4B Gene

protein-coding   GIFtS: 58
GCID: GC18P023806

TAF4b RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated...

(Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase...)
(Previous symbol: TAF2C2)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TAF4b RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated
Factor, 105kDa1 2
     Transcription Initiation Factor TFIID 105 KDa Subunit2 3
TAF2C21 2 3 5     TAF(II)1052 3
TAFII1052 3 5     TAFII-1052 3
TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, C2,
105kD1 2
     Transcription Initiation Factor TFIID 105 KD Subunit2
TATA Box Binding Protein (TBP)-Associated Factor 4B1 2     Transcription Initiation Factor TFIID Subunit 4B2

External Ids:    HGNC: 115381   Entrez Gene: 68752   Ensembl: ENSG000001413847   OMIM: 6016895   UniProtKB: Q927503   

Export aliases for TAF4B gene to outside databases

Previous GC identifers: GC18P023722 GC18P023538 GC18P022037 GC18P022039 GC18P020657


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TAF4B Gene:
TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein
complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell
type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells.
(provided by RefSeq, Sep 2011)

GeneCards Summary for TAF4B Gene:
TAF4B (TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa) is a protein-coding gene. Diseases associated with TAF4B include retinal detachment, and premature ovarian failure. GO annotations related to this gene include NF-kappaB binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TAF4.

UniProtKB/Swiss-Prot: TAF4B_HUMAN, Q92750
Function: Cell type-specific subunit of TFIID that may function as a gene-selective coactivator in certain cells.
TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various
activators and repressors. TAFII105 is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved
in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating
folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription

Gene Wiki entry for TAF4B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TAF4B gene promoter:
         Elk-1   Pax-5   HNF-4alpha2   IRF-1   HNF-4alpha1   HNF-1A   Max   AREB6   HNF-1   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TAF4B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAF4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q11.2   Ensembl cytogenetic band:  18q11.2   HGNC cytogenetic band: 18q11.1

TAF4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAF4B gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P023806:  view genomic region     (about GC identifiers)

Start:
23,805,900 bp from pter      End:
23,971,649 bp from pter
Size:
165,750 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TAF4B_HUMAN, Q92750 (See protein sequence)
Recommended Name: Transcription initiation factor TFIID subunit 4B  
Size: 862 amino acids; 91091 Da
Subunit: TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs).
Heterodimerizes with TAF12/TFII20 via the C-terminal H2A-like histone-fold domain. This heterodimer forms a
histone-like octamer with the TAF6/TAFII70-TAF9/TAFII31 heterodimer. Interacts with P65/RELA homodimers and
P65/RELA-REL heterodimers. Interaction with POU2AF1, via its C-terminal activation domain, is required for
octamer-dependent transcription
Secondary accessions: Q29YA4 Q29YA5
Alternative splicing: 2 isoforms:  Q92750-1   Q92750-2   (May be due to exon inclusion. No experimental confirmation available. Unphosphorylated form)

Explore the universe of human proteins at neXtProt for TAF4B: NX_Q92750

Explore proteomics data for TAF4B at MOPED

Post-translational modifications: 

  • Under stimulation by forskolin, Isoform 1 is phosphorylated by protein kinase A (PKA)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TAF4B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005631.1  
    ENSEMBL proteins: 
     ENSP00000269142   ENSP00000462980   ENSP00000389365   ENSP00000383314  
    Reactome Protein details: Q92750

    TAF4B Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR007900 TAF4
     IPR003894 TAFH_NHR1
     IPR009072 Histone-fold

    Graphical View of Domain Structure for InterPro Entry Q92750

    ProtoNet protein and cluster: Q92750

    2 Blocks protein domains:
    IPB003894 TAF-like region
    IPB007900 Transcription initiation factor TFIID component TAF4


    UniProtKB/Swiss-Prot: TAF4B_HUMAN, Q92750
    Similarity: Belongs to the TAF4 family
    Similarity: Contains 1 histone-fold domain
    Similarity: Contains 1 TAFH (NHR1) domain


    TAF4B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAF4B_HUMAN, Q92750
    Function: Cell type-specific subunit of TFIID that may function as a gene-selective coactivator in certain cells.
    TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various
    activators and repressors. TAFII105 is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved
    in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating
    folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA15601843
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0046982protein heterodimerization activity IEA--
    GO:0051059NF-kappaB binding IPI10849440
         
    TAF4B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TAF4B:
     Decreased viability 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Taf4b):
     cellular  endocrine/exocrine gland  homeostasis/metabolism  mortality/aging  reproductive system 

    TAF4B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Taf4btm1Rtj for TAF4B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TAF4B
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    Selected qRT-PCR Assays for microRNAs that regulate TAF4B (see all 45):
    hsa-miR-2052 hsa-miR-3607-3p hsa-miR-300 hsa-miR-374a hsa-miR-30d hsa-miR-301a hsa-miR-449a hsa-miR-30a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TAF4B_HUMAN, Q92750: Nucleus. Cytoplasm. Note=Export into the cytoplasm is mediated by a CRM1-independent nuclear
    export pathway and not by phosphorylation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005669transcription factor TFIID complex IEA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--

    TAF4B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TAF4B About   (see all 9)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    RNA Polymerase II Pre-transcription Events0.73
    RNA Polymerase II HIV Promoter Escape0.67
    Transcription of the HIV genome0.71
    RNA Polymerase II Transcription Pre-Initiation And Promoter Opening0.67
    RNA Polymerase II Transcription Initiation And Promoter Clearance0.67
    RNA Polymerase II Transcription Initiation0.67
    RNA Polymerase II Promoter Escape0.67
    RNA Polymerase II Transcription0.60
    2HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    3Assembly of RNA Polymerase-II Initiation Complex
    Basal transcription factors0.50
    4Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Huntington's disease0.45
    5Gene Expression
    Gene Expression0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for TAF4B
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 BioSystems Pathway for TAF4B
        Validated targets of C-MYC transcriptional activation

    Selected Reactome Pathways for TAF4B (see all 8)
        RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
    RNA Polymerase II Transcription Initiation And Promoter Clearance
    RNA Polymerase II Promoter Escape
    RNA Polymerase II Transcription Initiation
    Transcription of the HIV genome


    3 Kegg Pathways  (Kegg details for TAF4B):
        Basal transcription factors
    Huntington's disease
    Herpes simplex infection


    TAF4B for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TAF4B
    Interactions:

        GeneGlobe Interaction Network for TAF4B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TAF4B (Q927503 ENSP000002691424) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GTF2A1P526553, ENSP000002981734I2D: score=1 STRING: ENSP00000298173
    TAF1P216753, ENSP000002760724I2D: score=1 STRING: ENSP00000276072
    TBPP202263, ENSP000002303544I2D: score=1 STRING: ENSP00000230354
    TAF12Q165143, ENSP000002639744I2D: score=2 STRING: ENSP00000263974
    RELAQ042063, ENSP000003842734I2D: score=2 STRING: ENSP00000384273
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006352DNA-templated transcription, initiation ----
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--

    TAF4B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TAF4B



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TAF4B gene: 
    NM_005640.1  

    Unigene Cluster for TAF4B:

    TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
    Hs.369519  [show with all ESTs]
    Unigene Representative Sequence: NM_005640
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000269142(uc002kvu.4 uc002kvs.4 uc002kvt.4) ENST00000578121
    ENST00000418698 ENST00000400466
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    hsa-miR-2052 hsa-miR-3607-3p hsa-miR-300 hsa-miR-374a hsa-miR-30d hsa-miR-301a hsa-miR-449a hsa-miR-30a
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    Additional mRNA sequence: 

    AB234096.1 AK302593.1 AY888048.1 BC016360.1 BC032791.1 Y09321.1 

    3 DOTS entries:

    DT.442127  DT.101966187  DT.92420195 

    Selected AceView cDNA sequences (see all 41):

    BX952140 AA412656 BC016360 BX952116 AA458814 AA721195 AA287057 AA287145 
    BM853763 R24013 AA976562 AA252384 BG213757 BQ012407 AA825151 BC032791 
    AA976985 AL121204 BG217524 BI517527 W72761 Y09321 BM973282 AI366784 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TAF4B expression in normal human tissues (normalized intensities)      TAF4B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGCACATT
    TAF4B Expression
    About this image


    TAF4B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Spermatogonial Stem Cells Seminiferous Tubules
     
     Gonad
             Spermatogonial Stem Cells Seminiferous Tubules
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Granulosa Cells Primary Follicle
             oocyte   
    TAF4B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TAF4B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.369519

    UniProtKB/Swiss-Prot: TAF4B_HUMAN, Q92750
    Tissue specificity: Preferentially expressed in ovarian granulosa cells (at protein level). Highly expressed in
    B-cells

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF4B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TAF4B gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Taf4b1 , 5 TAF4B RNA polymerase II, TATA box binding protein (TBP)-associated more1, 5 85.02(n)1
    79.81(a)1
      18 (8.28 cM)5
    725041  NM_001100449.11  NP_001093919.11 
     147832455 
    chicken
    (Gallus gallus)
    Aves TAF4B1 TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated more 67.68(n)
    61.59(a)
      421086  XM_419170.4  XP_419170.4 
    lizard
    (Anolis carolinensis)
    Reptilia TAF4B6
    TAF4b RNA polymerase II, TATA box binding protein ...
    46(a)
    1 ↔ 1
    4(36730138-36808152)
    zebrafish
    (Danio rerio)
    Actinopterygii taf4b1 TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated more 55.44(n)
    52.16(a)
      100150678  XM_001920930.4  XP_001920965.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta Taf43 regulation of transcription,
    DNA-dependent general more
    47(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea taf-46
    Protein TAF-4 (taf-4) mRNA, complete cds
    23(a)
    1 → many
    I(382833-388847) WBGene00006385


    ENSEMBL Gene Tree for TAF4B (if available)
    TreeFam Gene Tree for TAF4B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TAF4B gene
    TAF42  
    2 SIMAP similar genes for TAF4B using alignment to 3 protein entries:     TAF4B_HUMAN (see all proteins):
    taf4b    TAF4

    TAF4B for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TAF4B
    PGOHUM00000246038


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TAF4B (see all 3260)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1447630131,2
    --23804503(+) AGTTTC/TTAAGT 1 -- us2k10--------
    rs1485406011,2
    --23804542(+) AATGCA/GTCTCT 1 -- us2k10--------
    rs99463861,2
    C,F--23804568(+) AGGAGG/ATGCTC 1 -- us2k12Minor allele frequency- A:0.15WA 120
    rs754122651,2
    C,F--23804578(+) CAATAA/CATTGA 1 -- us2k12Minor allele frequency- C:0.04WA 120
    rs578510151,2
    C,F--23804580(+) ATAAAT/GTGAGT 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs1161198891,2
    F--23804584(+) ATTGAG/ATTTTT 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs752013531,2
    F--23804599(+) CCCCAA/GCTCCA 1 -- us2k11Minor allele frequency- G:0.01EA 120
    rs1932925031,2
    --23804637(+) GATCAA/GGGAAT 1 -- us2k10--------
    rs1838452641,2
    --23804723(+) AGGTAA/GTAAGT 1 -- us2k10--------
    rs1418760451,2
    --23804884(+) AGCTTA/GTAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TAF4B (23805900 - 23971649 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TAF4B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2459954CNV Deletion19546169
    esv1519371CNV Insertion17803354
    nsv909471CNV Loss21882294
    nsv512522CNV Loss21212237

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for TAF4B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601689    OMIM disorders: --

    5 diseases for TAF4B:    About MalaCards
    retinal detachment    premature ovarian failure    huntington's disease    herpes simplex
    retinitis


    TAF4B for disorders           About GeneDecksing

    Genetic Association Database (GAD): TAF4B
    Human Genome Epidemiology (HuGE) Navigator: TAF4B (1 document)

    Export disorders for TAF4B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TAF4B gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with TAF4B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Interaction of TAFII105 with selected p65/RelA dimers is associated with activation of subset of NF-kappa B genes. (PubMed id 10849440)1, 2, 3 Yamit-Hezi A.... Dikstein R. (J. Biol. Chem. 2000)
    2. Human TAFII 105 is a cell type-specific TFIID subunit related to hTAFII130. (PubMed id 8858156)1, 2, 3 Dikstein R.... Tjian R. (Cell 1996)
    3. A composite nuclear export signal in the TBP-associated factor TAFII105. (PubMed id 11567023)1, 2, 9 Rashevsky-Finkel A.... Dikstein R. (J. Biol. Chem. 2001)
    4. Cyclic AMP-dependent modification of gonad-selective TAF(II)105 in a human ovarian granulosa cell line. (PubMed id 16088961)1, 2, 9 Wu Y.... Li R. (J. Cell. Biochem. 2005)
    5. Specific interaction of TAFII105 with OCA-B is involved in activation of octamer-dependent transcription. (PubMed id 10828057)1, 2, 9 Wolstein O.... Dikstein R. (J. Biol. Chem. 2000)
    6. Genome-wide association study in premature ovarian failure patients suggests ADAMTS19 as a possible candidate gene. (PubMed id 19508998)1, 4 Knauff E.A....Fauser B.C. (Hum. Reprod. 2009)
    7. Core promoter binding by histone-like TAF complexes. (PubMed id 15601843)1, 2 Shao H.... Dikstein R. (Mol. Cell. Biol. 2005)
    8. TAF4/4b x TAF12 displays a unique mode of DNA binding and is required for core promoter function of a subset of genes. (PubMed id 19635797)1, 9 Gazit K....Dikstein R. (J. Biol. Chem. 2009)
    9. Genome-wide association study identifies genetic risk underlying primary rhegmatogenous retinal detachment. (PubMed id 23585552)1 Kirin M....Mitry D. (Hum. Mol. Genet. 2013)
    10. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (PLoS Genet. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6875 HGNC: 11538 AceView: TAF4B Ensembl:ENSG00000141384 euGenes: HUgn6875
    ECgene: TAF4B Kegg: 6875 H-InvDB: TAF4B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TAF4B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TAF4B gene:
    Search GeneIP for patents involving TAF4B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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