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TAF4 Gene

protein-coding GIFtS: 60

GC20M059983

TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
(Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase II, C1, 130kD )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: TAF4A, TAF2C1, TAF2C)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ41943 ^²
TAF(II)135 ^³
TAF2C ^², ³, ⁵
TAF2C1 ^², ³, ⁵
TAF4A ^², ³
TAFII-130 ^³
TAFII-135 ^³
TAFII130 ^¹, ², ³, ⁵
TAFII135 ^¹, ², ³

Descriptions
RNA polymerase II TBP-associated factor subunit C ^³
TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135 kD ^²
TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa ^²
TAF4 RNA polymerase II, TATA box binding protein-associated factor, 135kDa ^¹
TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135 kD ^²
TATA box binding protein (TBP)-associated factor, RNA polymerase II, C1, 130kD ^¹, ²
TBP-associated factor 4 ^², ³
Transcription initiation factor TFIID 135 kDa subunit ^³
transcription initiation factor TFIID 135 kD subunit ^²

External Ids
HGNC: 11537¹
Entrez Gene: 6874²
UniProtKB: O00268³
Ensembl: ENSG00000130699⁷

Search outside databases for aliases for TAF4 gene

Previous GC identifers: GC20M060313 GC20M061166 GC20M061235

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TAF4:

Initiation of transcription by RNA polymerase II requires the activities of more than 70

polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID),

which binds to the core promoter to position the polymerase properly, serves as the scaffold for

assembly of the remainder of the transcription complex, and acts as a channel for regulatory

signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily

conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal

transcription, serve as coactivators, function in promoter recognition or modify general

transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This

gene encodes one of the larger subunits of TFIID that has been shown to potentiate transcriptional

activation by retinoic acid, thyroid hormone and vitamin D3 receptors. In addition, this subunit

interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and

binds to other proteins containing glutamine-rich regions. Aberrant binding to this subunit by

proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic

mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine

diseases. [provided by RefSeq]

UniProtKB/Swiss-Prot: TAF4_HUMAN, O00268

Function: Makes part of TFIID is a multimeric protein complex that plays a central role in

mediating promoter responses to various activators and repressors. Potentiates transcriptional

activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone

Gene Wiki entry for TAF4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TAF4 gene

Entrez Gene cytogenetic band: 20q13.33 Ensembl cytogenetic band: 20q13.33 HGNC cytogenetic band: 20q13.33

TAF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20M059983: (about GC identifiers)

Start:	59,983,249 bp from pter
End:	60,074,261 bp from pter
Size:	91,013 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000020.9 NT_011362.9

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TAF4_HUMAN, O00268 (See protein sequence)

Recommended Name: Transcription initiation factor TFIID subunit 4

Size: 1085 amino acids; 110114 Da

Subunit: TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors

(TAFs). Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H,

TAF2, TAF4, TAF5, GCN5L2/GCN5, TAF10 and TRRAP. Interacts with SV40 Large T antigen

Subcellular location: Nucleus

PDB structure from and Proteopedia :

1H3O (3D)

2P6V (3D)

Secondary accessions: A6NGD9 Q5TBP6 Q99721 Q9BR40 Q9BX42

REFSEQ proteins: NP_003176.2

ENSEMBL proteins:

ENSP00000252996 ENSP00000349471

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Taf4)
	Human Recombinant Proteins from Abnova (TAF4)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005669	transcription factor TFIID complex	IDA	14580349
GO:0005730	NOT nucleolus	IDA	18029348
GO:0005737	cytoplasm	IDA	18029348

About this table

Antibodies for TAF4:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for TAF4
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Taf4), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibody for TAF4

Assays for TAF4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O00268

ProtoNet protein and cluster: O00268

2 Blocks protein families:

IPB003894 TAF-like region

IPB007900 Transcription initiation factor TFIID component TAF4

UniProtKB/Swiss-Prot: TAF4_HUMAN, O00268

Similarity: Belongs to the TAF4 family

Similarity: Contains 1 TAFH (NHR1) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TAF4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TAF4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003185

Applied Biosystems Silencer® siRNAs for TAF4

Sigma-Aldrich siRNA for TAF4

Sigma-Aldrich shRNA for TAF4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_003185
Myc/DDK tagged cDNA clone in CMV expression vector: NM_003185
untagged cDNA clones in CMV expression vector (see all 2): NM_003185

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003185

UniProtKB/Swiss-Prot: TAF4_HUMAN, O00268

Function: Makes part of TFIID is a multimeric protein complex that plays a central role in

mediating promoter responses to various activators and repressors. Potentiates transcriptional

activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone

8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Taf4a):

cellular	growth/size	homeostasis/metabolism	immune system	lethality-prenatal/perinatal
limbs/digits/tail	skin/coat/nails	tumorigenesis

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IEA	--
GO:0003713	transcription coactivator activity	TAS	9192867
GO:0005515	protein binding	TAS	8942982
GO:0016251	general RNA polymerase II transcription factor activity	TAS	8942982
GO:0016986	transcription initiation factor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

4 Sigma-Aldrich "Your Favorite Gene" Pathways for TAF4 (Your Favorite Gene powered by Ingenuity)

Glucocorticoid Receptor Signaling
Estrogen Receptor Signaling
Huntington's Disease Signaling
RAR Activation

GeneDecks TAF4 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for TAF4

5/96 Interacting proteins for TAF4 (ENSP00000252996³ O00268²) via UniProtKB, MINT, and/or STRING (see all 96 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDK8	P49336²	STRING (score=.906) MINT-6744616
KAT2A	Q92830²	STRING (score=.851) MINT-6744616
MED1	Q15648²	STRING (score=.899) MINT-6744616
HTT	P42858²	MINT-16025 MINT-16026
MED15	Q96RN5²	MINT-6744616

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006352	transcription initiation	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TAF4

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TAF4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TAF4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_003185

Sigma-Aldrich siRNA for TAF4

Sigma-Aldrich shRNA for TAF4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_003185

REFSEQ mRNAs for TAF4 gene:

NM_003185.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_003185

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_003185
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_003185
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_003185

Additional cDNA sequence:

AK097268.1 AK097744.1 AK123937.1 U75308.1 Y11354.1

10 DOTS entries:

DT.100801110 DT.100689087 DT.316603 DT.95135507 DT.100035104 DT.92422521 DT.95103674 DT.95117734

DT.97784750 DT.91896877

24/98 AceView cDNA sequences (see all 98 ):

H01461 AA487148 AA430176 BQ690529 AA810715 AI886593 BE349938 BU528666

BE465382 AA331385 BQ025239 AA937227 BM665879 BM718673 BE302229 AA994049

W32194 AA630360 R72727 BQ575177 BU742345 BQ684840 AA996280 BQ025504

highest scoring ESTs for TAF4:

U75308 Y11354 AA053537 AA148415 AA322472 AA331385 AA360405 AA430176 AA446484 AA487148

Unigene Cluster for TAF4:

TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa

Hs.18857 [show with all ESTs]

Unigene Representative Sequence: NM_003185

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for TAF4

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20a	·	20b	·	20c
SP1:									-		-								-																				-		-
SP2:																																							-		-
SP3:
SP4:

About this scheme

ECgene alternative splicing isoforms for TAF4

2 Ensembl transcripts including schematic representations:

ENST00000252996 ENST00000356981

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TAF4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TAF4

¹ / ² / ³

5 probe-sets matching TAF4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
142_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U75308	1.00	1.00	1.00	1
208545_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003185	0.60	1.00	0.82	1
213090_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI744029	0.60	1.00	0.82	1
208545_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
213090_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TAAATTTTGC

SOURCE GeneReport for Unigene cluster: Hs.18857
Expression variation in blood from EXPOLDB for TAF4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TAF4 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	TAF4¹	--	TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated more	99.53(n) 99.8(a)	458381 XM_514759.2 XP_514759.2
mouse (Mus musculus)	Taf4a^{1, 5}	2⁵	TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated more^{1, 5}	86.05(n)¹ 88.79(a)¹	228980¹ NM_001081092.1¹ NP_001074561.1¹ AA541869⁵ AI450312⁵ (see all 13)
chicken (Gallus gallus)	TAF4¹	--	TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated more	70.59(n) 74.57(a)	419223 XM_417400.2 XP_417400.2
zebrafish (Danio rerio)	LOC100149942¹	--	similar to TAF4 RNA polymerase II, TATA box binding more	58.06(n) 58.31(a)	100149942 XM_001920909.1 XP_001920944.1
fruit fly (Drosophila melanogaster)	Taf4³	3 72D7--8	regulation of transcription, DNA-dependent general more	52(a)	--

About this table Species with no ortholog for TAF4

ENSEMBL Gene Tree for TAF4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TAF4 gene

TAF4B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/761 NCBI SNPs in TAF4 are shown (see all 761 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 339)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1046137^1,2	C,F	59983477(-)	`GAGCGC/TGTGTG`	1	--	ut3¹ ese³		8	MN NS	1008
	rs7266262^1,2	F,H	60076117(+)	`AGTCGG/AGGCAG`	1	--	ng3¹		4	EU EA WA	412
	rs28382133^1,2	F	59982891(-)	`GTGGCG/AAGAGA`	1	--	ng5¹		1	NS	156
	rs6142914^1,2	H	60006609(+)	`TCAGCC/TTTAAC`	1	R/K	mis¹ ese³		4	EU EA WA	420
	rs4414752^1,2	H	60016024(+)	`AGGTTG/AAGGTG`	1	X/Q	non¹ ese³		4	EU EA WA	420
	rs6061949^1,2	H	60012214(+)	`GCTGAG/AGCGTG`	1	L/P	mis¹ ese³		4	EU EA WA	420
	rs28382134^1,2	F	59982768(-)	`GGAGAG/ACCTTT`	1	--	ng5¹		1	NS	156
	rs6061950^1,2	H	60012241(+)	`TGTGAG/AGCTGC`	1	L/P	mis¹ ese³		4	EU EA WA	420
	rs8120120^1,2	H	59983718(+)	`CATTTC/TTATGT`	1	--	ut3¹		4	EU EA WA	418
	rs28381990^1,2	F	60075954(-)	`AGATTT/AAATCA`	1	--	ng3¹		1	NS	170

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HapMap Linkage Disequilibrium images for TAF4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601796

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/40 PubMed articles for TAF4 gene (see all 40 ):

Human TAF(II)135 potentiates transcriptional activation by the AF-2s of the retinoic acid, vitamin D3, and thyroid hormone receptors in mammalian cells. (PubMed id 9192867)^{2, 3, 4} Mengus G....Davidson I. (1997)
Molecular cloning and analysis of two subunits of the human TFIID complex: hTAFII130 and hTAFII100. (PubMed id 8942982)^{2, 3, 4} Tanese N....Admon A. (1996)
The human TFIID components TAF(II)135 and TAF(II)20 and the yeast SAGA components ADA1 and TAF(II)68 heterodimerize to form histone-like pairs. (PubMed id 10594036)^{1, 3, 4} Gangloff Y.-G....Davidson I. (2000)
Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis. (PubMed id 12601814)^{3, 4} Cavusoglu N....Van Dorsselaer A. (2003)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{3, 4} Deloukas P....Rogers J. (2001)
Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction. (PubMed id 10373431)^{3, 4} Brand M.... Tora L. (1999)
Induced alpha-helix structure in the aryl hydrocarbon receptor transactivation domain modulates protein-protein interactions. (PubMed id 15641800)^{1, 3} Watt K....McEwan I.J. (2005)
Structural changes in TAF4b-TFIID correlate with promoter selectivity. (PubMed id 18206971)³ Liu W.L....Tjian R. (2008)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)³ Barbe L....Andersson-Svahn H. (2008)
A functional interaction between ATF7 and TAF12 that is modulated by TAF4. (PubMed id 15735663)³ Hamard P.J....Chatton B. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6874	HGNC: 11537	AceView: TAF4	Ensembl:ENSG00000130699	euGenes: HUgn6874
ECgene: TAF4	H-InvDB: TAF4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
NIEHS-SNPs	http://egp.gs.washington.edu/data/taf4/

Licensable Technologies for TAF4
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for TAF4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TAF4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TAF4		Antibodies for TAF4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for TAF4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Antibodies for TAF4

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TAF4 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for TAF4

Summaries
for TAF4

Genomic Location
for TAF4

Proteins
for TAF4

Protein Domains/
Families
for TAF4

Gene Function
for TAF4

Pathways & Interactions
for TAF4

Drugs & Compounds
for TAF4

Transcripts
for TAF4

Expression
for TAF4

Orthologs
for TAF4

Paralogs
for TAF4

SNPs/Variants
for TAF4

Disorders & Mutations
for TAF4

Medical News
for TAF4

Publications
for TAF4

Search for TAF4

Genome Databases showing TAF4

Other Databases showing TAF4

Specialized Databases showing TAF4

Licensable Technologies
for TAF4

Services
for TAF4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TAF4 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor TAF4

Summariesfor TAF4

Genomic Locationfor TAF4

Proteinsfor TAF4

Protein Domains/Familiesfor TAF4

Gene Functionfor TAF4

Pathways & Interactionsfor TAF4

Drugs & Compoundsfor TAF4

Transcriptsfor TAF4

Expression for TAF4

Orthologsfor TAF4

Paralogsfor TAF4

SNPs/Variantsfor TAF4

Disorders & Mutationsfor TAF4

Medical Newsfor TAF4

Publicationsfor TAF4

Search for TAF4

Genome Databases showing TAF4

Other Databases showing TAF4

Specialized Databases showing TAF4

Licensable Technologiesfor TAF4

Servicesfor TAF4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TAF4

Summaries
for TAF4

Genomic Location
for TAF4

Proteins
for TAF4

Protein Domains/
Families
for TAF4

Gene Function
for TAF4

Pathways & Interactions
for TAF4

Drugs & Compounds
for TAF4

Transcripts
for TAF4

Expression
for TAF4

Orthologs
for TAF4

Paralogs
for TAF4

SNPs/Variants
for TAF4

Disorders & Mutations
for TAF4

Medical News
for TAF4

Publications
for TAF4

Licensable Technologies
for TAF4

Services
for TAF4