Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TAF4 Gene

protein-coding   GIFtS: 65
GCID: GC20M060529

TAF4 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated...

(Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase...)
(Previous symbols: TAF4A, TAF2C1, TAF2C)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
TAF4 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated
Factor, 135kDa1 2
     TAF(II)1352 3
TAF2C1 2 3 5     TAFII-1302 3
TAF2C11 2 3 5     TAFII-1352 3
TAF4A1 2 3     TAFII1352 3
TAFII1302 3 5     RNA Polymerase II TBP-Associated Factor Subunit C2 3
TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, C1,
130kD1 2
     TBP-Associated Factor 42 3
Transcription Initiation Factor TFIID 130 KDa Subunit2 3     TAF4A RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor,
135 KD2
Transcription Initiation Factor TFIID 135 KDa Subunit2 3     Transcription Initiation Factor TFIID 135 KD Subunit2
TAF(II)1302 3     Transcription Initiation Factor TFIID Subunit 42

External Ids:    HGNC: 115371   Entrez Gene: 68742   Ensembl: ENSG000001306997   OMIM: 6017965   UniProtKB: O002683   

Export aliases for TAF4 gene to outside databases

Previous GC identifers: GC20M060313 GC20M061166 GC20M061235 GC20M059983 GC20M057327


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TAF4 Gene:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein
that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to
position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription
complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a
group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal
transcription, serve as coactivators, function in promoter recognition or modify general transcription factors
(GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits
of TFIID that has been shown to potentiate transcriptional activation by retinoic acid, thyroid hormone and
vitamin D3 receptors. In addition, this subunit interacts with the transcription factor CREB, which has a
glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions. Aberrant binding
to this subunit by proteins with expanded polyglutamine regions has been suggested as one of the pathogenetic
mechanisms underlying a group of neurodegenerative disorders referred to as polyglutamine diseases. (provided by
RefSeq, Jul 2008)

GeneCards Summary for TAF4 Gene:
TAF4 (TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa) is a protein-coding gene. Diseases associated with TAF4 include progeria, and thyroiditis. GO annotations related to this gene include transcription coactivator activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TAF4B.

UniProtKB/Swiss-Prot: TAF4_HUMAN, O00268
Function: Part of the TFIID complex, a multimeric protein complex that plays a central role in mediating promoter
responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the
retinoic acid, vitamin D3 and thyroid hormone

Gene Wiki entry for TAF4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011362.11  NT_187623.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the TAF4 gene promoter:
         Sp1   MyoD   CBF-C   CBF-A   CBF-B   CP1A   CP1C   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAF4 promoter sequence
   Search Chromatin IP Primers for TAF4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAF4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.33   Ensembl cytogenetic band:  20q13.33   HGNC cytogenetic band: 20q13.33

TAF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAF4 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M060529:  view genomic region     (about GC identifiers)

Start:
60,528,525 bp from pter      End:
60,640,866 bp from pter
Size:
112,342 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TAF4_HUMAN, O00268 (See protein sequence)
Recommended Name: Transcription initiation factor TFIID subunit 4  
Size: 1085 amino acids; 110114 Da
Subunit: TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Component
of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H, TAF2, TAF4, TAF5, GCN5L2/GCN5, TAF10
and TRRAP. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L,
HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1,
LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4,
TAF6, TAF7, TAF9 and TEX10. Interacts with ATF7; the interaction inhibits ATF7-mediated tranactivation. Interacts
with SV40 Large T antigen
2 PDB 3D structures from and Proteopedia for TAF4:
1H3O (3D)        2P6V (3D)    
Secondary accessions: A6NGD9 Q5TBP6 Q99721 Q9BR40 Q9BX42

Explore the universe of human proteins at neXtProt for TAF4: NX_O00268

Explore proteomics data for TAF4 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys611
  • Modification sites at PhosphoSitePlus

  • See TAF4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003176.2  
    ENSEMBL proteins: 
     ENSP00000476270   ENSP00000252996   ENSP00000476294  
    Reactome Protein details: O00268

    TAF4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TAF4
    GenScript Custom Purified and Recombinant Proteins Services for TAF4
    Novus Biologicals TAF4 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TAF4

    TAF4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TAF4
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TAF4
    OriGene Custom Antibody Services for TAF4
    Novus Biologicals TAF4 Antibodies
    Abcam antibodies for TAF4
    Cloud-Clone Corp. Antibodies for TAF4
    Search ThermoFisher Antibodies for TAF4
    LSBio Antibodies in human, mouse, rat for TAF4

    TAF4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TAF4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TAF4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TAF4
    Cloud-Clone Corp. CLIAs for TAF4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR007900 TAF4
     IPR003894 TAFH_NHR1
     IPR009072 Histone-fold

    Graphical View of Domain Structure for InterPro Entry O00268

    ProtoNet protein and cluster: O00268

    2 Blocks protein domains:
    IPB003894 TAF-like region
    IPB007900 Transcription initiation factor TFIID component TAF4


    UniProtKB/Swiss-Prot: TAF4_HUMAN, O00268
    Similarity: Belongs to the TAF4 family
    Similarity: Contains 1 TAFH (NHR1) domain


    TAF4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAF4_HUMAN, O00268
    Function: Part of the TFIID complex, a multimeric protein complex that plays a central role in mediating promoter
    responses to various activators and repressors. Potentiates transcriptional activation by the AF-2S of the
    retinoic acid, vitamin D3 and thyroid hormone

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA15601843
    GO:0003700contributes to sequence-specific DNA binding transcription factor activity IDA9603525
    GO:0003713transcription coactivator activity TAS9192867
    GO:0005515protein binding IPI15735663
    GO:0046982protein heterodimerization activity IEA--
         
    TAF4 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for TAF4:
     G0/1 arrest  Increased G1 DNA content  Increased homologous recombina  Upregulation of Wnt/beta-caten 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Taf4a):
     cellular  growth/size/body  homeostasis/metabolism  immune system  integument 
     limbs/digits/tail  mortality/aging  tumorigenesis 

    TAF4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Taf4atm1.1Idvd for TAF4

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TAF4
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TAF4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TAF4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TAF4

    miRNA
    Products:
        
    miRTarBase miRNAs that target TAF4:
    hsa-mir-93-5p (MIRT048812), hsa-mir-7-5p (MIRT047763), hsa-mir-19b-3p (MIRT031295)

    Block miRNA regulation of human, mouse, rat TAF4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TAF4 (see all 63):
    hsa-miR-579 hsa-miR-548j hsa-miR-429 hsa-miR-548k hsa-miR-128 hsa-miR-301a hsa-miR-3167 hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidTAF4 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TAF4
    Predesigned siRNA for gene silencing in human, mouse, rat TAF4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TAF4

    Clone
    Products:
         
    OriGene clones in human, mouse for TAF4 (see all 5)
    OriGene ORF clones in mouse, rat for TAF4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TAF4 (NM_003185)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAF4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAF4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TAF4
    Browse ESI BIO Cell Lines and PureStem Progenitors for TAF4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TAF4_HUMAN, O00268: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005669transcription factor TFIID complex IDA14580349
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--

    TAF4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TAF4 About   (see all 13)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Assembly of RNA Polymerase-II Initiation Complex
    Assembly of RNA Polymerase-II Initiation Complex0.91
    Basal transcription factors0.50
    Transcription of mRNA0.91
    Crosstalk Between CARM1 and ESRs0.39
    Protein Acetylation and Deacetylation0.51
    2Formation of RNA Pol II elongation complex
    RNA Polymerase II Pre-transcription Events0.73
    RNA Polymerase II HIV Promoter Escape0.67
    Transcription of the HIV genome0.71
    RNA Polymerase II Transcription Pre-Initiation And Promoter Opening0.67
    RNA Polymerase II Transcription Initiation And Promoter Clearance0.67
    RNA Polymerase II Transcription Initiation0.67
    RNA Polymerase II Promoter Escape0.67
    RNA Polymerase II Transcription0.60
    3HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    4Apoptotic Pathways in Synovial Fibroblasts
    Nuclear Receptor Activation by Vitamin-A0.57
    5GPCR Pathway
    Estrogen Pathway0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TAF4 (see all 8)
        Nuclear Receptor Activation by Vitamin-A
    Protein Acetylation and Deacetylation
    Glucocorticoid Receptor Signaling
    Estrogen Pathway
    Crosstalk Between CARM1 and ESRs

    1 GeneGo (Thomson Reuters) Pathway for TAF4
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    Selected Reactome Pathways for TAF4 (see all 8)
        RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
    RNA Polymerase II Transcription Initiation And Promoter Clearance
    RNA Polymerase II Promoter Escape
    RNA Polymerase II Transcription Initiation
    Transcription of the HIV genome


    3 Kegg Pathways  (Kegg details for TAF4):
        Basal transcription factors
    Huntington's disease
    Herpes simplex infection


    TAF4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TAF4
    Interactions:

        GeneGlobe Interaction Network for TAF4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TAF4 (O002682, 3 ENSP000002529964) via UniProtKB, MINT, STRING, and/or I2D (see all 136)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HTTP428582, 3, ENSP000003471844MINT-16025 MINT-16026 I2D: score=3 STRING: ENSP00000347184
    KAT2AQ928302, 3, ENSP000002259164MINT-6744616 I2D: score=2 STRING: ENSP00000225916
    TAF9Q165943, ENSP000002178934I2D: score=3 STRING: ENSP00000370201 STRING: ENSP00000217893
    AHRP358693, ENSP000002420574I2D: score=3 STRING: ENSP00000242057
    CREMQ030603, ENSP000002653724I2D: score=3 STRING: ENSP00000265372
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001541ovarian follicle development IEA--
    GO:0006352DNA-templated transcription, initiation IDA9603525
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter ----
    GO:0006366transcription from RNA polymerase II promoter TAS--

    TAF4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TAF4

    1 HMDB Compound for TAF4    About this table
    CompoundSynonyms CAS #PubMed Ids
    Vitamin D3(+)-Vitamin D3 (see all 32)67-97-0--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TAF4 gene: 
    NM_003185.3  

    Unigene Cluster for TAF4:

    TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
    Hs.18857  [show with all ESTs]
    Unigene Representative Sequence: NM_003185
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000474089 ENST00000252996(uc002ybs.3) ENST00000436129 ENST00000608458
    ENST00000488539 ENST00000609041 ENST00000486599 ENST00000609045 ENST00000608887

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TAF4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TAF4 (see all 63):
    hsa-miR-579 hsa-miR-548j hsa-miR-429 hsa-miR-548k hsa-miR-128 hsa-miR-301a hsa-miR-3167 hsa-miR-4275
    SwitchGear 3'UTR luciferase reporter plasmidTAF4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TAF4
    Predesigned siRNA for gene silencing in human, mouse, rat TAF4
    Clone
    Products:
         
    OriGene clones in human, mouse for TAF4 (see all 5)
    OriGene ORF clones in mouse, rat for TAF4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TAF4 (NM_003185)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAF4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAF4
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TAF4
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TAF4
      QuantiTect SYBR Green Assays in human, mouse, rat TAF4
      QuantiFast Probe-based Assays in human, mouse, rat TAF4

    Additional mRNA sequence: 

    AK097268.1 AK097744.1 AK123937.1 U75308.1 Y11354.1 

    9 DOTS entries:

    DT.100801110  DT.100689087  DT.316603  DT.100035104  DT.92422521  DT.95135507  DT.95117734  DT.97784750 
    DT.95103674 

    Selected AceView cDNA sequences (see all 98):

    AA430176 AI032467 BQ685051 AA996280 BM718673 BE465382 BE302229 BQ025504 
    BE349938 AA630360 AA810715 BQ575177 W32194 BM665879 BU742345 R72727 
    H01461 BU528666 BQ684840 AA994049 AA331385 BQ025239 AI886593 BQ690529 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TAF4    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c
    SP1:                          -     -                       -                                                           -     -                     
    SP2:                                                                                                                    -     -                     
    SP3:                                                                                                                                                
    SP4:                                                                                                                                                


    ECgene alternative splicing isoforms for TAF4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TAF4 expression in normal human tissues (normalized intensities)      TAF4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAAATTTTGC
    TAF4 Expression
    About this image


    TAF4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    TAF4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TAF4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.18857
        Custom PCR Arrays for TAF4
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TAF4
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TAF4
    QuantiTect SYBR Green Assays in human, mouse, rat TAF4
    QuantiFast Probe-based Assays in human, mouse, rat TAF4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TAF4 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Taf4a1 , 5 TAF4A RNA polymerase II, TATA box binding protein (TBP)-associated more1, 5 83.74(n)1
    86.5(a)1
      2 (102.42 cM)5
    2289801  NM_001081092.11  NP_001074561.11 
     1799121525 
    chicken
    (Gallus gallus)
    Aves TAF41 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated more 77.51(n)
    87.31(a)
      419223  XM_417400.4  XP_417400.2 
    lizard
    (Anolis carolinensis)
    Reptilia TAF46
    TAF4 RNA polymerase II, TATA box binding protein (...
    56(a)
    1 ↔ 1
    4(150442267-150548065)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.343622 Xenopus laevis transcribed sequence with moderate similarity more 82.41(n)    BG514288.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001499421 transcription initiation factor TFIID subunit 4-like 63.99(n)
    68.26(a)
      100149942  XM_005172888.1  XP_005172945.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Taf43 regulation of transcription,
    DNA-dependent general more
    52(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea taf-46
    Protein TAF-4 (taf-4) mRNA, complete cds
    25(a)
    1 → many
    I(382833-388847) WBGene00006385
    rice
    (Oryza sativa)
    Liliopsida AK099989.12   -- 72.56(n)    AK099989.1 


    ENSEMBL Gene Tree for TAF4 (if available)
    TreeFam Gene Tree for TAF4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TAF4 gene
    TAF4B2  
    2 SIMAP similar genes for TAF4 using alignment to 3 protein entries:     TAF4_HUMAN (see all proteins):
    TAF4B    taf4b

    TAF4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TAF4 (see all 2480)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs283821341,2
    C,F--60549373(-) GGAGAG/ACCTTT 1 -- ds50015Minor allele frequency- A:0.09NS WA CSA 278
    rs283821331,2
    C,F--60549496(-) GTGGCG/AAGAGA 1 -- ds50012Minor allele frequency- A:0.05NS WA 274
    rs283821321,2
    C,F--60549595(-) GCGGCG/AGGAGG 1 -- ds50013Minor allele frequency- A:0.02NS CSA WA 276
    rs283821311,2
    C,F--60549612(-) GGGCAC/TAGCTA 1 -- ds50013Minor allele frequency- T:0.03NS WA 276
    rs283821301,2
    C,F--60549661(-) GCTGGC/TGGCTG 1 -- ds50011Minor allele frequency- T:0.01NS 156
    rs747584891,2
    F--60549727(+) TCTCCC/TGGCTC 1 -- ds50011Minor allele frequency- T:0.01NA 120
    rs1407826751,2
    --60549759(+) TCCAAC/GAGGTG 1 -- ds50010--------
    rs10461371,2
    C,F,H--60550082(-) GAGCGC/TGTGTG 1 -- ut31 ese316Minor allele frequency- T:0.02MN NS NA 2066
    rs1497048111,2
    --60550084(+) CACGCA/GCTCGA 1 -- ut310--------
    rs791331781,2
    C--60550087(+) GCGCTA/CGAATT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TAF4 (60528525 - 60640866 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TAF4 (see all 38):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1640297CNV Deletion17803354
    esv2722774CNV Deletion23290073
    esv2375011CNV Deletion18987734
    esv2722762CNV Deletion23290073
    esv2722773CNV Deletion23290073
    esv2662438CNV Deletion23128226
    dgv710e201CNV Deletion23290073
    esv2550695CNV Deletion19546169
    nsv821030CNV Deletion20802225
    esv4304CNV Deletion18987735

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TAF4
    DNA2.0 Custom Variant and Variant Library Synthesis for TAF4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601796    OMIM disorders: --

    11 diseases for TAF4:    About MalaCards
    progeria    thyroiditis    huntington's disease    herpes simplex
    hiv-1    tonsillitis    hypertension    retinitis
    cerebritis    endotheliitis    prostatitis


    TAF4 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): TAF4
    Human Genome Epidemiology (HuGE) Navigator: TAF4 (3 documents)

    Export disorders for TAF4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TAF4 gene, integrated from 10 sources (see all 72):
    (articles sorted by number of sources associating them with TAF4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human TAF(II)135 potentiates transcriptional activation by the AF-2s of the retinoic acid, vitamin D3, and thyroid hormone receptors in mammalian cells. (PubMed id 9192867)1, 2, 3 Mengus G.... Davidson I. (Genes Dev. 1997)
    2. Molecular cloning and analysis of two subunits of the human TFIID complex: hTAFII130 and hTAFII100. (PubMed id 8942982)1, 2, 3 Tanese N.... Admon A. (Proc. Natl. Acad. Sci. U.S.A. 1996)
    3. The human TFIID components TAF(II)135 and TAF(II)20 and the yeast SAGA components ADA1 and TAF(II)68 heterodimerize to form histone-like pairs. (PubMed id 10594036)1, 2, 9 Gangloff Y.-G....Davidson I. (Mol. Cell. Biol. 2000)
    4. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PubMed id 20198315)1, 4 Yoshida T....Yamada Y. (Int. J. Mol. Med. 2010)
    5. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PubMed id 19851296)1, 4 Oguri M....Yamada Y. (Am. J. Hypertens. 2010)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    7. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. (PubMed id 15960975)1, 2 Dou Y.... Roeder R.G. (Cell 2005)
    8. A functional interaction between ATF7 and TAF12 that is modulated by TAF4. (PubMed id 15735663)1, 2 Hamard P.J....Chatton B. (Oncogene 2005)
    9. Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one- dimensional gel electrophoresis. (PubMed id 12601814)1, 2 Cavusoglu N.... van Dorsselaer A. (Proteomics 2003)
    10. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 6874 HGNC: 11537 AceView: TAF4 Ensembl:ENSG00000130699 euGenes: HUgn6874
    ECgene: TAF4 Kegg: 6874 H-InvDB: TAF4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TAF4 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/taf4/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TAF4 gene:
    Search GeneIP for patents involving TAF4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of TAF4
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TAF4   OriGene RNAi products in human, mouse, rat for TAF4  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TAF4  
     OriGene qSTAR qPCR primer pairs in human, mouse for TAF4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TAF4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TAF4   OriGene Custom Protein Services for TAF4  

     
     
     Block miRNA regulation of human, mouse, rat TAF4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TAF4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAF4 Predesigned siRNA for gene silencing in human, mouse, rat TAF4
     QuantiFast Probe-based Assays in human, mouse, rat TAF4 QuantiTect SYBR Green Assays in human, mouse, rat TAF4
     Custom PCR Arrays for TAF4 Search Chromatin IP Primers for TAF4
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TAF4  GeneGlobe Interaction Network for TAF4
     Regulatory tfbs in TAF4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TAF4 GenScript cDNA clones with any tag delivered in your preferred vector for TAF4
     GenScript Custom Assay Services for TAF4 GenScript Custom overexpressing Cell Line Services for TAF4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TAF4
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TAF4 antibodies
     TAF4 proteins
     Antibodies for TAF4
     See all of Abcam's Antibodies, Kits and Proteins for TAF4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TAF4
     Antibodies for TAF4
     ELISAs for TAF4
     CLIAs for TAF4



     Browse ESI BIO Cell Lines and PureStem Progenitors for TAF4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF4
     SwitchGear 3'UTR luciferase reporter plasmids for TAF4
     SwitchGear Promoter luciferase reporter plasmids for TAF4
     Search ThermoFisher Antibodies for TAF4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAF4
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TAF4
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TAF4
     LSBio Antibodies in human, mouse, rat for TAF4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TAF4 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4