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Aliases for TAF3 Gene

Aliases for TAF3 Gene

  • TATA-Box Binding Protein Associated Factor 3 2 3 5
  • TAF3 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 140kDa 2 3
  • Transcription Initiation Factor TFIID 140 KDa Subunit 3 4
  • 140 KDa TATA Box-Binding Protein-Associated Factor 3 4
  • TBP-Associated Factor 3 3 4
  • TAF(II)140 3 4
  • TAFII-140 3 4
  • TAFII140 3 4
  • TAF140 3 4
  • TAF3 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 140 KD 2
  • RNA Polymerase II Transcription Factor TAFII140 3
  • Transcription Initiation Factor TFIID Subunit 3 3

External Ids for TAF3 Gene

Previous GeneCards Identifiers for TAF3 Gene

  • GC10P007805
  • GC10M007824
  • GC10P008010
  • GC10P007864
  • GC10P007898

Summaries for TAF3 Gene

Entrez Gene Summary for TAF3 Gene

  • The highly conserved RNA polymerase II transcription factor TFIID (see TAF1; MIM 313650) comprises the TATA box-binding protein (TBP; MIM 600075) and a set of TBP-associated factors (TAFs), including TAF3. TAFs contribute to promoter recognition and selectivity and act as antiapoptotic factors (Gangloff et al., 2001 [PubMed 11438666]).[supplied by OMIM, May 2009]

GeneCards Summary for TAF3 Gene

TAF3 (TATA-Box Binding Protein Associated Factor 3) is a Protein Coding gene. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Gene Expression. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and p53 binding.

UniProtKB/Swiss-Prot for TAF3 Gene

  • Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process.

Gene Wiki entry for TAF3 Gene

Additional gene information for TAF3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF3 Gene

Genomics for TAF3 Gene

GeneHancer (GH) Regulatory Elements for TAF3 Gene

Promoters and enhancers for TAF3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I007817 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.2 239 2.3 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 TAF3 ATP5F1C ITIH2 GC10M007828
GH10I008049 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 17.9 +238.6 238572 16 HDGF PKNOX1 FOXA2 MLX SIN3A FEZF1 ZNF2 ZNF213 E2F8 ZNF143 GATA3 KIN TAF3 SFMBT2 GATA3-AS1 ENSG00000232638 GC10P008092 GC10M008036 GC10M008037
GH10I007872 Enhancer 0.9 Ensembl ENCODE 10.8 +53.9 53924 0.4 CTCF ZNF384 ZNF2 RAD21 ZNF335 ZNF366 ARID2 ZNF143 SMC3 ZNF362 TAF3 KIN ATP5F1C GC10P007866 GC10M007907
GH10I008702 Enhancer 0.9 ENCODE 10.4 +884.3 884348 1.6 PKNOX1 SIN3A FEZF1 ZNF2 ZNF121 ZNF213 ZNF302 KLF7 ZNF548 FOS KIN TAF3 GC10P008711 RNA5SP299 GC10M008656 LOC105376400
GH10I007480 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 4.2 -335.0 -335034 6.5 PKNOX1 BMI1 BATF IRF4 YY1 ATF7 ETV6 BCLAF1 IKZF2 RUNX3 SFMBT2 TAF3 KIN GC10M007486 RNU6-535P LOC105376388
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TAF3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TAF3 gene promoter:

Genomic Locations for TAF3 Gene

Genomic Locations for TAF3 Gene
chr10:7,818,477-8,016,631
(GRCh38/hg38)
Size:
198,155 bases
Orientation:
Plus strand
chr10:7,860,467-8,058,590
(GRCh37/hg19)

Genomic View for TAF3 Gene

Genes around TAF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF3 Gene

Proteins for TAF3 Gene

  • Protein details for TAF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VWG9-TAF3_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 3
    Protein Accession:
    Q5VWG9
    Secondary Accessions:
    • Q05DA0
    • Q6GMS5
    • Q6P6B5
    • Q86VY6
    • Q9BQS9
    • Q9UFI8

    Protein attributes for TAF3 Gene

    Size:
    929 amino acids
    Molecular mass:
    103582 Da
    Quaternary structure:
    • Belongs to the TFIID complex which is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts with TAF10 via the histone fold. Interacts with TAF13, TBP, SAP130 and GCN5L2. Interacts with TBPL2.
    SequenceCaution:
    • Sequence=AAH45106.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH62352.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH73884.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TAF3 Gene

neXtProt entry for TAF3 Gene

Post-translational modifications for TAF3 Gene

No Post-translational modifications

Other Protein References for TAF3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAF3 Gene

Domains & Families for TAF3 Gene

Gene Families for TAF3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TAF3 Gene

Graphical View of Domain Structure for InterPro Entry

Q5VWG9

UniProtKB/Swiss-Prot:

TAF3_HUMAN :
  • The PHD-type zinc finger mediates binding to histone H3 methyllysine at position 4 (H3K4me3).
  • Belongs to the TAF3 family.
Domain:
  • The PHD-type zinc finger mediates binding to histone H3 methyllysine at position 4 (H3K4me3).
Family:
  • Belongs to the TAF3 family.
genes like me logo Genes that share domains with TAF3: view

Function for TAF3 Gene

Molecular function for TAF3 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process.

Phenotypes From GWAS Catalog for TAF3 Gene

Gene Ontology (GO) - Molecular Function for TAF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IEA --
GO:0005515 protein binding IPI 11438666
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TAF3: view
genes like me logo Genes that share phenotypes with TAF3: view

miRNA for TAF3 Gene

miRTarBase miRNAs that target TAF3

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAF3 Gene

Localization for TAF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAF3 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TAF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15870280
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex IDA 11438666
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with TAF3: view

Pathways & Interactions for TAF3 Gene

genes like me logo Genes that share pathways with TAF3: view

Pathways by source for TAF3 Gene

Gene Ontology (GO) - Biological Process for TAF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 18549481
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with TAF3: view

No data available for SIGNOR curated interactions for TAF3 Gene

Drugs & Compounds for TAF3 Gene

No Compound Related Data Available

Transcripts for TAF3 Gene

mRNA/cDNA for TAF3 Gene

Unigene Clusters for TAF3 Gene

TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAF3 Gene

No ASD Table

Relevant External Links for TAF3 Gene

GeneLoc Exon Structure for
TAF3
ECgene alternative splicing isoforms for
TAF3

Expression for TAF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TAF3 Gene

This gene is overexpressed in Testis (10.3), Lung (10.2), Tlymphocyte (8.8), Fetal Liver (8.3), Pancreas (8.1), and Stomach (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TAF3 Gene



NURSA nuclear receptor signaling pathways regulating expression of TAF3 Gene:

TAF3

SOURCE GeneReport for Unigene cluster for TAF3 Gene:

Hs.527688

Evidence on tissue expression from TISSUES for TAF3 Gene

  • Liver(4.2)
  • Skin(4.1)
  • Bone(4)
genes like me logo Genes that share expression patterns with TAF3: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAF3 Gene

Orthologs for TAF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TAF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF3 33 34
  • 99.03 (n)
cow
(Bos Taurus)
Mammalia TAF3 34
  • 89 (a)
OneToOne
LOC506674 33
  • 82.49 (n)
dog
(Canis familiaris)
Mammalia TAF3 33 34
  • 85.72 (n)
rat
(Rattus norvegicus)
Mammalia Taf3 33
  • 83.57 (n)
mouse
(Mus musculus)
Mammalia Taf3 33 16 34
  • 83.39 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TAF3 34
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAF3 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAF3 33 34
  • 75.59 (n)
lizard
(Anolis carolinensis)
Reptilia TAF3 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia taf3 33
  • 67.29 (n)
Str.8912 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.13976 33
zebrafish
(Danio rerio)
Actinopterygii taf3 34
  • 52 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6361 33
fruit fly
(Drosophila melanogaster)
Insecta bip2 34
  • 17 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea taf-3 34
  • 20 (a)
OneToOne
Species where no ortholog for TAF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAF3 Gene

ENSEMBL:
Gene Tree for TAF3 (if available)
TreeFam:
Gene Tree for TAF3 (if available)

Paralogs for TAF3 Gene

No data available for Paralogs for TAF3 Gene

Variants for TAF3 Gene

Sequence variations from dbSNP and Humsavar for TAF3 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000025050 -- 7,901,498(+) A/G intron_variant
rs1000044105 -- 7,906,541(+) A/G intron_variant
rs1000047604 -- 7,989,753(+) G/A intron_variant
rs1000056059 -- 7,901,230(+) TTT/TT intron_variant
rs1000058139 -- 7,985,068(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TAF3 Gene

Variant ID Type Subtype PubMed ID
dgv91e201 CNV deletion 23290073
dgv92e201 CNV deletion 23290073
dgv953n54 CNV loss 21841781
esv1001263 CNV insertion 20482838
esv24837 CNV loss 19812545
esv26156 CNV gain 19812545
esv2732428 CNV deletion 23290073
esv3545867 CNV deletion 23714750
esv3545868 CNV deletion 23714750
esv3578606 CNV loss 25503493
esv3622278 CNV loss 21293372
nsv1041904 CNV loss 25217958
nsv1145425 CNV deletion 24896259
nsv526356 CNV gain 19592680
nsv526540 CNV loss 19592680
nsv549933 CNV gain 21841781
nsv549945 CNV loss 21841781
nsv549948 CNV loss 21841781

Variation tolerance for TAF3 Gene

Residual Variation Intolerance Score: 11.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.23; 52.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAF3 Gene

Human Gene Mutation Database (HGMD)
TAF3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAF3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF3 Gene

Disorders for TAF3 Gene

Additional Disease Information for TAF3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TAF3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAF3 Gene

Publications for TAF3 Gene

  1. The TFIID components human TAF(II)140 and Drosophila BIP2 (TAF(II)155) are novel metazoan homologues of yeast TAF(II)47 containing a histone fold and a PHD finger. (PMID: 11438666) Gangloff YG … Davidson I (Molecular and cellular biology 2001) 2 3 4 58
  2. Novel association strategy with copy number variation for identifying new risk Loci of human diseases. (PMID: 20808825) Chen X … Kong X (PloS one 2010) 3 44 58
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 44 58
  4. Gene variants associated with ischemic stroke: the cardiovascular health study. (PMID: 19023099) Luke MM … Psaty BM (Stroke 2009) 3 44 58
  5. TATA binding protein associated factor 3 (TAF3) interacts with p53 and inhibits its function. (PMID: 18549481) Bereczki O … Balint E (BMC molecular biology 2008) 2 3 58

Products for TAF3 Gene

  • Addgene plasmids for TAF3

Sources for TAF3 Gene

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