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Aliases for TAF3 Gene

Aliases for TAF3 Gene

  • TAF3 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 140kDa 2 3
  • TAFII140 3 4 6
  • Transcription Initiation Factor TFIID 140 KDa Subunit 3 4
  • 140 KDa TATA Box-Binding Protein-Associated Factor 3 4
  • TBP-Associated Factor 3 3 4
  • TAF(II)140 3 4
  • TAFII-140 3 4
  • TAF140 3 4
  • TAF3 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 140 KD 2
  • RNA Polymerase II Transcription Factor TAFII140 3
  • Transcription Initiation Factor TFIID Subunit 3 3

External Ids for TAF3 Gene

Summaries for TAF3 Gene

Entrez Gene Summary for TAF3 Gene

  • The highly conserved RNA polymerase II transcription factor TFIID (see TAF1; MIM 313650) comprises the TATA box-binding protein (TBP; MIM 600075) and a set of TBP-associated factors (TAFs), including TAF3. TAFs contribute to promoter recognition and selectivity and act as antiapoptotic factors (Gangloff et al., 2001 [PubMed 11438666]).[supplied by OMIM, May 2009]

GeneCards Summary for TAF3 Gene

TAF3 (TAF3 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 140kDa) is a Protein Coding gene. Among its related pathways are Influenza A and Assembly of RNA Polymerase-II Initiation Complex. GO annotations related to this gene include p53 binding.

UniProtKB/Swiss-Prot for TAF3 Gene

  • Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process

Gene Wiki entry for TAF3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF3 Gene

Genomics for TAF3 Gene

Genomic Location for TAF3 Gene

Start:
7,818,504 bp from pter
End:
8,016,627 bp from pter
Size:
198,124 bases
Orientation:
Plus strand

Genomic View for TAF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF3 Gene

Regulatory Elements for TAF3 Gene

Proteins for TAF3 Gene

  • Protein details for TAF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VWG9-TAF3_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 3
    Protein Accession:
    Q5VWG9
    Secondary Accessions:
    • Q05DA0
    • Q6GMS5
    • Q6P6B5
    • Q86VY6
    • Q9BQS9
    • Q9UFI8

    Protein attributes for TAF3 Gene

    Size:
    929 amino acids
    Molecular mass:
    103582 Da
    Quaternary structure:
    • Belongs to the TFIID complex which is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts with TAF10 via the histone fold. Interacts with TAF13, TBP, SAP130 and GCN5L2. Interacts with TBPL2.
    SequenceCaution:
    • Sequence=AAH45106.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH62352.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH73884.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TAF3 Gene

Proteomics data for TAF3 Gene at MOPED

Post-translational modifications for TAF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAF3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAF3 Gene

Domains for TAF3 Gene

Gene Families for TAF3 Gene

HGNC:
  • PHF :Zinc fingers, PHD-type

UniProtKB/Swiss-Prot:

TAF3_HUMAN
Domain:
  • The PHD-type zinc finger mediates binding to histone H3 methyllysine at position 4 (H3K4me3).:
    • Q5VWG9
Family:
  • Belongs to the TAF3 family.:
    • Q5VWG9
Similarity:
  • Contains 1 PHD-type zinc finger.:
    • Q5VWG9
genes like me logo Genes that share domains with TAF3: view

Function for TAF3 Gene

Molecular function for TAF3 Gene

UniProtKB/Swiss-Prot Function: Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Required in complex with TBPL2 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process

Gene Ontology (GO) - Molecular Function for TAF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IEA --
GO:0005515 protein binding IPI 11438666
GO:0008270 zinc ion binding IEA --
GO:0046982 protein heterodimerization activity --
genes like me logo Genes that share ontologies with TAF3: view

Phenotypes for TAF3 Gene

genes like me logo Genes that share phenotypes with TAF3: view

miRNA for TAF3 Gene

miRTarBase miRNAs that target TAF3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TAF3 Gene

Localization for TAF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAF3 Gene COMPARTMENTS Subcellular localization image for TAF3 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2

Gene Ontology (GO) - Cellular Components for TAF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15870280
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex IDA 11438666
genes like me logo Genes that share ontologies with TAF3: view

Pathways for TAF3 Gene

genes like me logo Genes that share pathways with TAF3: view

Pathways by source for TAF3 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for TAF3 Gene

Gene Ontology (GO) - Biological Process for TAF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 18549481
GO:0006351 transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with TAF3: view

Transcripts for TAF3 Gene

mRNA/cDNA for TAF3 Gene

Unigene Clusters for TAF3 Gene

TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAF3 Gene

No ASD Table

Relevant External Links for TAF3 Gene

GeneLoc Exon Structure for
TAF3
ECgene alternative splicing isoforms for
TAF3

Expression for TAF3 Gene

mRNA expression in normal human tissues for TAF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAF3 Gene

SOURCE GeneReport for Unigene cluster for TAF3 Gene Hs.527688

genes like me logo Genes that share expressions with TAF3: view

Orthologs for TAF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TAF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF3 36
  • 99.03 (n)
  • 98.92 (a)
TAF3 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC506674 36
  • 82.49 (n)
  • 87.75 (a)
TAF3 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAF3 36
  • 85.72 (n)
  • 88.81 (a)
TAF3 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taf3 36
  • 83.39 (n)
  • 85.29 (a)
Taf3 16
Taf3 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TAF3 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAF3 37
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Taf3 36
  • 83.57 (n)
  • 86.39 (a)
chicken
(Gallus gallus)
Aves TAF3 36
  • 75.59 (n)
  • 78.29 (a)
TAF3 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAF3 37
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13976 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.8912 36
taf3 36
  • 67.29 (n)
  • 66.41 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6361 36
zebrafish
(Danio rerio)
Actinopterygii taf3 37
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta bip2 37
  • 17 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea taf-3 37
  • 20 (a)
OneToOne
Species with no ortholog for TAF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAF3 Gene

ENSEMBL:
Gene Tree for TAF3 (if available)
TreeFam:
Gene Tree for TAF3 (if available)

Paralogs for TAF3 Gene

No data available for Paralogs for TAF3 Gene

Variants for TAF3 Gene

Sequence variations from dbSNP and Humsavar for TAF3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1246 -- 7,859,920(-) TGAGA(C/T)GGATT intron-variant
rs155415 -- 7,936,996(-) gatac(A/G)gagga intron-variant
rs166411 -- 8,010,210(-) ATGCA(C/T)CTTgg intron-variant
rs174498 -- 7,969,830(-) TTCCA(C/G)CCCGG intron-variant
rs187821 -- 7,939,559(-) TTCCT(A/G)CATTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAF3 Gene

Variant ID Type Subtype PubMed ID
esv1001263 CNV Insertion 20482838
esv2732428 CNV Deletion 23290073
esv24837 CNV Loss 19812545
dgv103e201 CNV Deletion 23290073
dgv104e201 CNV Deletion 23290073
esv26156 CNV Gain 19812545
nsv526356 CNV Gain 19592680
nsv894851 CNV Loss 21882294
nsv526540 CNV Loss 19592680

Relevant External Links for TAF3 Gene

HapMap Linkage Disequilibrium report
TAF3
Human Gene Mutation Database (HGMD)
TAF3

Disorders for TAF3 Gene

Relevant External Links for TAF3

Genetic Association Database (GAD)
TAF3
Human Genome Epidemiology (HuGE) Navigator
TAF3
genes like me logo Genes that share disorders with TAF3: view

No data available for UniProtKB/Swiss-Prot for TAF3 Gene

Publications for TAF3 Gene

  1. The TFIID components human TAFII140 and Drosophila BIP2 (TAFII155) are novel metazoan homologues of yeast TAFII47 containing a histone fold and a PHD finger. (PMID: 11438666) Gangloff Y.G. … Davidson I. (Mol. Cell. Biol. 2001) 2 3 4
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  4. Novel association strategy with copy number variation for identifying new risk Loci of human diseases. (PMID: 20808825) Chen X. … Kong X. (PLoS ONE 2010) 3 49
  5. Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PMID: 17975119) Shiffman D. … Psaty B.M. (Arterioscler. Thromb. Vasc. Biol. 2008) 3 49

Products for TAF3 Gene

Sources for TAF3 Gene

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