Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TAF2 Gene

protein-coding GIFtS: 57
GCID: GC08M120812

TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated...

(Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase...)
(Previous symbol: TAF2B)

Explore 1 disease affiliated with
TAF2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
TAF2 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 150kDa¹ ²		TAF(II)150² ³
CIF150¹ ² ³		TAFII-150² ³
TAF2B¹ ² ³		RNA Polymerase II TBP-Associated Factor Subunit B² ³
TAFII150¹ ² ³		TBP-Associated Factor 150 KDa² ³
TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, B, 150kD¹ ²		Cofactor Of Initiator Function, 150kD Subunit²
Transcription Initiation Factor TFIID 150 KDa Subunit² ³		Transcription Initiation Factor TFIID Subunit 2²
150 KDa Cofactor Of Initiator Function² ³

External Ids:	HGNC: 11536¹	Entrez Gene: 6873²	Ensembl: ENSG00000064313⁷	OMIM: 604912⁵	UniProtKB: Q6P1X5³

Export aliases for TAF2 gene to outside databases

Previous GC identifers: GC08M119730 GC08M120749 GC08M120411 GC08M120699 GC08M116063

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TAF2:

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that

coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the

polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a

channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily

conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as

coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex

assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated

with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site,

interactions that help determine transcription complex response to activators. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TAF2_HUMAN, Q6P1X5

Function: Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by

RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to

various activators and repressors. It requires core promoter-specific cofactors for productive transcription

stimulation. TAF2 stabilizes TFIID binding to core promoter

Gene Wiki entry for TAF2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_008046.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TAF2 gene promoter:
STAT1 HOXA3 AML1a Nkx2-2 STAT1beta Nkx2-5 GATA-1 STAT1alpha FOXJ2 (long isoform) FOXJ2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TAF2 promoter sequence

Search SABiosciences Chromatin IP Primers for TAF2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAF2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.12 Ensembl cytogenetic band: 8q24.12 HGNC cytogenetic band: 8q24

TAF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAF2 gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M120812: view genomic region (about GC identifiers)

Start:	120,743,014 bp from pter	End:	120,845,103 bp from pter
Size:	102,090 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TAF2_HUMAN, Q6P1X5 (See protein sequence)

Recommended Name: Transcription initiation factor TFIID subunit 2

Size: 1199 amino acids; 136971 Da

Subunit: Component of transcription factor TFIID which is composed of TBP and a number of TBP-associated factors.

Interacts with TAF2C1. Component of the TFTC-HAT complex

Subcellular location: Nucleus

Miscellaneous: PubMed:9418870 was unable to show an association between TAF2 and TFIID

Sequence caution: Sequence=AAC68502.1; Type=Erroneous initiation; Sequence=AAH64830.1; Type=Miscellaneous discrepancy;

Note=Contaminating sequence. Potential poly-A sequence;

Secondary accessions: B2RE82 O43487 O43604 O60668 Q86WW7 Q8IWK4

Explore the universe of human proteins at neXtProt for TAF2: NX_Q6P1X5

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6P1X5

TAF2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003175.1

ENSEMBL proteins:

ENSP00000367406 ENSP00000436750 ENSP00000428690 ENSP00000430832 ENSP00000428484

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: TAF2 OriGene Custom Protein Services for TAF2
	GenScript Custom Purified and Recombinant Proteins Services for TAF2
	Novus Biologicals TAF2 Protein Novus Biologicals TAF2 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TAF2

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005669	colocalizes with transcription factor TFIID complex	IDA	10409744
GO:0033276	transcription factor TFTC complex	IDA	10373431

TAF2 for ontologies About GeneDecksing

TAF2 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies: TAF2 OriGene Custom Antibody Services for TAF2
	GenScript Custom Superior Antibodies Services for TAF2
	Novus Biologicals TAF2 Antibodies
	Search for Antibodies for TAF2 at Abcam
	Uscn Antibodies for TAF2
	ThermoFisher Antibody for TAF2

Assay Products for TAF2:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TAF2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TAF2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TAF2 for domains About GeneDecksing

2 InterPro domains/families:

IPR014782 Peptidase_M1_N

IPR016024 ARM-type_fold

Graphical View of Domain Structure for InterPro Entry Q6P1X5

ProtoNet protein and cluster: Q6P1X5

1 Blocks protein family: IPB001930 Membrane alanyl dipeptidase (M1) family signature

UniProtKB/Swiss-Prot: TAF2_HUMAN, Q6P1X5

Similarity: Belongs to the TAF2 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TAF2_HUMAN, Q6P1X5

Function: Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by

RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to

various activators and repressors. It requires core promoter-specific cofactors for productive transcription

stimulation. TAF2 stabilizes TFIID binding to core promoter

miRNA Products:		OriGene 3'-UTR Clone: TAF2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TAF2
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate TAF2:
		hsa-miR-140-3p hsa-miR-548t hsa-miR-466 hsa-miR-548n hsa-miR-3182
		SwitchGear 3'UTR luciferase reporter plasmid: TAF2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TAF2 (see all 7) OriGene shRNA RFP: TAF2 OriGene siRNA: TAF2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAF2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TAF2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAF2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAF2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TAF2 (NM_003184)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAF2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAF2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TAF2
		Search LifeMap BioReagents cell lines for TAF2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	9418870
GO:0008237	metallopeptidase activity	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0044212	transcription regulatory region DNA binding	IMP	10409744

TAF2 for ontologies About GeneDecksing

5 GenomeRNAi human phenotypes for TAF2:

Decreased NANOG protein expres	Decreased OCT4 protein express	Decreased POU5F1-GFP protein e	Decreased viability
Decreased viability of wild-ty

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Assembly of RNA Polymerase-II Initiation Complex

Assembly of RNA Polymerase-II Initiation Complex	1.00	Basal transcription factors	0.49
Transcription of mRNA	0.91	Crosstalk Between CARM1 and ESRs	0.32
Protein Acetylation and Deacetylation	0.51

HIV Infection

Transcription_Ligand-Dependent Transcription of Retinoid-Target genes

0.28

Transcription Ligand-Dependent Transcription of Retinoid-Target genes

0.28

Androgen Signaling

Androgen Signaling

1.00

Apoptotic Pathways in Synovial Fibroblasts

Nuclear Receptor Activation by Vitamin-A

0.57

GPCR Pathway

Estrogen Pathway

0.55

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for TAF2

	Histone modification
	Transcription Ligand-Dependent Transcription of Retinoid-Target genes

5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TAF2 (see all 8)

	Nuclear Receptor Activation by Vitamin-A
	Protein Acetylation and Deacetylation
	Androgen Signaling
	Glucocorticoid Receptor Signaling
	Estrogen Pathway

1 GeneGo (Thomson Reuters) Pathway for TAF2

Transcription Ligand-Dependent Transcription of Retinoid-Target genes

1 Kegg Pathway (Kegg details for TAF2):

Basal transcription factors

TAF2 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TAF2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/97 Interacting proteins for TAF2 (Q6P1X5³ ENSP00000367406⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 97)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H2BC	P62807³	I2D: score=1
HIST1H2BE	P62807³	I2D: score=1
HIST1H2BF	P62807³	I2D: score=1
HIST1H2BG	P62807³	I2D: score=1
HIST1H2BI	P62807³	I2D: score=1

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000086	G2/M transition of mitotic cell cycle	IMP	10409744
GO:0006367	transcription initiation from RNA polymerase II promoter	IDA	9418870
GO:0014070	response to organic cyclic compound	--	--
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IMP	10409744

TAF2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TAF2
Search CenterWatch for drugs/clinical trials and news about TAF2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TAF2 gene:

NM_003184.3

Unigene Cluster for TAF2:

TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa

Hs.122752 [show with all ESTs]

Unigene Representative Sequence: NM_003184

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000378164(uc003you.3) ENST00000529653 ENST00000526969 ENST00000519355

ENST00000523078 ENST00000523098 ENST00000523904 ENST00000523734 ENST00000521007

miRNA Products:		OriGene 3'-UTR Clone: TAF2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TAF2
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate TAF2:
		hsa-miR-140-3p hsa-miR-548t hsa-miR-466 hsa-miR-548n hsa-miR-3182
		SwitchGear 3'UTR luciferase reporter plasmid: TAF2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TAF2 (see all 7) OriGene shRNA RFP: TAF2 OriGene siRNA: TAF2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAF2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAF2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAF2 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: TAF2 (NM_003184)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TAF2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAF2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAF2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TAF2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAF2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAF2

Additional cDNA sequence:

AF026445.1 AF040701.1 AF057694.1 AK001618.1 AK001909.1 AK316592.1 AL137601.1 BC008473.1

BC018010.1 BC035673.2 BC037262.1 BC047732.1 BC064830.1

11 DOTS entries:

DT.210351 DT.95172572 DT.100862526 DT.101976333 DT.120632559 DT.92039731 DT.100643486 DT.102828677

DT.91820931 DT.92435446 DT.95172559

24/149 AceView cDNA sequences (see all 149):

BE645277 AI393239 BX091764 AI373838 AL137601 BF001811 AW963035 BQ959501

BQ427717 AI653879 AU132255 AK001909 BM974263 AL040173 AA768610 AU098502

AA594294 AI358531 AI990807 CA416456 AI420493 NM_003184 CD655766 AA700638

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TAF2 (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19a	·	19b	·	19c	^
SP1:																																															-
SP2:
SP3:
SP4:
SP5:											-

ExUns:	20a	·	20b	^	21a	·	21b	·	21c	^	22	^	23a	·	23b	^	24a	·	24b	^	25a	·	25b	^	26	^	27	^	28a	·	28b
SP1:	-		-						-												-		-
SP2:									-												-		-
SP3:									-
SP4:
SP5:

ECgene alternative splicing isoforms for TAF2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TAF2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCTTTAATA

About this image
See TAF2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TAF2

SOURCE GeneReport for Unigene cluster: Hs.122752

UniProtKB/Swiss-Prot: TAF2_HUMAN, Q6P1X5

Tissue specificity: Expressed in all tissues tested

SABiosciences Custom PCR Arrays for TAF2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAF2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TAF2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAF2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAF2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TAF2 gene from 9/28 species (see all 28) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Taf2^{1 , 5}	TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated more^{1, 5}	88.65(n)¹ 95.74(a)¹		15 (21.96 cM)⁵ 319944¹ NM_001081288.1¹ NP_001074757.1¹ 55015129⁵
chicken (Gallus gallus)	Aves	TAF2¹	TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated more	83.54(n) 95.38(a)		428389 XM_003640856.1 XP_003640904.1
lizard (Anolis carolinensis)	Reptilia	TAF2⁶	--	89(a)	1 ↔ 1	GL343269.1(1045853-1095419)
African clawed frog (Xenopus laevis)	Amphibia	Xl.32372²	Xenopus laevis transcribed sequence with moderate similarity more	78.73(n)		BJ615523.1
zebrafish (Danio rerio)	Actinopterygii	BU710501.1²	--	76.28(n)		325123 BU710501.1
fruit fly (Drosophila melanogaster)	Insecta	Taf2^{1 , 3}	transcription initiation from Pol II promoter more³ TBP-associated factor 2¹	52(a)³ 52.58(n)¹ 50.22(a)¹		3 67D1³ 39164¹ NM_168387.2¹ NP_729571.1¹
worm (Caenorhabditis elegans)	Secernentea	taf-2^{1 , 3}	TATA binding protein associated factor³ Protein TAF-2¹	32(a)³ 45.28(n)¹ 34.28(a)¹		IV(3584735-3593599)³ 192051¹ NM_067977.2¹ NP_500378.1¹
thale cress (Arabidopsis thaliana)	eudicotyledons	TAF2¹	TBP-associated factor 2	45.83(n) 31(a)		843733 NM_001036202.1 NP_001031279.1
rice (Oryza sativa)	Liliopsida	--	expressed protein	17(a)	1 ↔ 1	9(14530189-14546559)

ENSEMBL Gene Tree for TAF2 (if available)
TreeFam Gene Tree for TAF2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs149182927^1,2		--	120742673(+)	`AAATAA/GTTTCA`	1	--	ds500¹		0	--	--	--	--
rs183777704^1,2		--	120742795(+)	`ATTCCC/TGAATA`	1	--	ds500¹		0	--	--	--	--
rs79379505^1,2	F,	--	120742894(+)	`CTAGTG/CAGGCC`	1	--	ds500¹		1		WA	118
rs188758758^1,2		--	120742898(+)	`TGAGGC/GCAGCT`	1	--	ds500¹		0	--	--	--	--
rs193292228^1,2		--	120743127(+)	`AAAAAC/TTGAAC`	1	--	ut3¹		0	--	--	--	--
rs184955647^1,2		--	120743224(+)	`ATTTCA/GTATGT`	1	--	ut3¹		0	--	--	--	--
rs143354451^1,2		--	120743363(+)	`GGTGTA/GTAAAT`	1	--	ut3¹		0	--	--	--	--
rs188105460^1,2		--	120743516(+)	`TAACCA/GCCGAA`	1	--	ut3¹		0	--	--	--	--
rs191515730^1,2		--	120743537(+)	`AAAGAC/TAGTTA`	1	--	ut3¹		0	--	--	--	--
rs184031809^1,2		--	120743663(+)	`AAAATC/GGTGCA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TAF2 (120743014 - 120845103 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TAF2
1 CNV: 100487
2 Indels: 65250 47449
Human Gene Mutation Database (HGMD): TAF2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAF2

DNA2.0 Custom Variant and Variant Library Synthesis for TAF2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TAF2 for disorders           About GeneDecksing

OMIM gene information: 604912    OMIM disorders: --

1 disease for TAF2:    About MalaCards

immunodeficiency

Export disorders for TAF2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TAF2 gene, integrated from 9 sources (see all 46):
(articles sorted by number of sources associating them with TAF2)

Utopia: connect your pdf to the dynamic
world of online information

Novel cofactors and TFIIA mediate functional core promoter selectivity by the human TAFII150-containing TFIID complex. (PubMed id 9774672)^{1, 2, 3} Martinez E.... Roeder R.G. (1998)
CIF150, a human cofactor for transcription factor IID-dependent initiator function. (PubMed id 9418870)^{1, 2, 3} Kaufmann J....Muller R. (1998)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one- dimensional gel electrophoresis. (PubMed id 12601814)^{1, 2} Cavusoglu N.... van Dorsselaer A. (2003)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)
The protein network surrounding the human telomere re peat binding factors TRF1, TRF2, and POT1. (PubMed id 20811636)¹ Giannone R.J....Liu Y. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 6873	HGNC: 11536	AceView: TAF2	Ensembl:ENSG00000064313	euGenes: HUgn6873
ECgene: TAF2	Kegg: 6873	H-InvDB: TAF2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TAF2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TAF2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TAF2 gene:
Search GeneIP for patents involving TAF2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for TAF2		OriGene shRNA RFP for TAF2
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TAF2		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAF2
	OriGene Protein Over-expression Lysate for TAF2		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for TAF2		OriGene 3'-UTR Clone for TAF2
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAF2		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAF2
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TAF2		OriGene Custom Protein Services for TAF2
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TAF2
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAF2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAF2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAF2
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAF2
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAF2

	GenScript Custom Purified and Recombinant Proteins Services for TAF2		GenScript cDNA clones with any tag delivered in your preferred vector for TAF2
	GenScript Custom Assay Services for TAF2		GenScript Custom Superior Antibodies Services for TAF2
	GenScript Custom overexpressing Cell Line Services for TAF2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in TAF2 promoter
	Search Chromatin IP Primers for TAF2
	RT² qPCR Primer Assay in human, mouse, rat TAF2
	GNC Network for TAF2
	SABiosciences PCR Arrays including human, mouse, rat TAF2

Search Tocris compounds for TAF2

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	TAF2 antibodies
	TAF2 proteins
	TAF2 lysates

	Search for Antibodies for TAF2 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for TAF2
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

TAF2 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for TAF2

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF2

	SwitchGear 3'UTR luciferase reporter plasmids for TAF2
	SwitchGear Promoter luciferase reporter plasmids for TAF2

ThermoFisher Antibody for TAF2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAF2

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TAF2 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

TAF2 Gene

TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated...

Aliases
for TAF2 gene

Summaries
for TAF2 gene

Genomic Views
for TAF2 gene

Proteins
for TAF2 gene

Protein Domains /
Families
for TAF2 gene

Function
for TAF2 gene

Pathways & Interactions
for TAF2 gene

Drugs & Compounds
for TAF2 gene

Transcripts
for TAF2 gene

Expression
for TAF2 gene

Orthologs
for TAF2 gene

Paralogs
for TAF2 gene

Genomic Variants
for TAF2 gene

Disorders / Diseases
for TAF2 gene

Publications
for TAF2 gene

External Searches for TAF2 gene

Genome Databases showing TAF2 gene

Other Databases showing TAF2 gene

Specialized Databases showing TAF2 gene

Intellectual Property
for TAF2 gene

Products
for TAF2 gene

View Random Gene

Advanced Search

Export list of displayed genes

TAF2 Gene

TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated...

Aliasesfor TAF2 gene

Summariesfor TAF2 gene

Genomic Viewsfor TAF2 gene

Proteinsfor TAF2 gene

Protein Domains /Familiesfor TAF2 gene

Functionfor TAF2 gene

Pathways & Interactionsfor TAF2 gene

Drugs & Compoundsfor TAF2 gene

Transcriptsfor TAF2 gene

Expression for TAF2 gene

Orthologsfor TAF2 gene

Paralogsfor TAF2 gene

Genomic Variantsfor TAF2 gene

Disorders / Diseasesfor TAF2 gene

Publicationsfor TAF2 gene

External Searches for TAF2 gene

Genome Databases showing TAF2 gene

Other Databases showing TAF2 gene

Specialized Databases showing TAF2 gene

Intellectual Propertyfor TAF2 gene

Productsfor TAF2 gene

View Random Gene

Aliases
for TAF2 gene

Summaries
for TAF2 gene

Genomic Views
for TAF2 gene

Proteins
for TAF2 gene

Protein Domains /
Families
for TAF2 gene

Function
for TAF2 gene

Pathways & Interactions
for TAF2 gene

Drugs & Compounds
for TAF2 gene

Transcripts
for TAF2 gene

Expression
for TAF2 gene

Orthologs
for TAF2 gene

Paralogs
for TAF2 gene

Genomic Variants
for TAF2 gene

Disorders / Diseases
for TAF2 gene

Publications
for TAF2 gene

Intellectual Property
for TAF2 gene

Products
for TAF2 gene