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TAF2 Gene

protein-coding   GIFtS: 60
GCID: GC08M120743

TAF2 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated...

(Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase...)
(Previous symbol: TAF2B)
  See TAF2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TAF2 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated
Factor, 150kDa1 2
     TAF(II)1502 3
TAF2B1 2 3 5     RNA Polymerase II TBP-Associated Factor Subunit B2 3
CIF1502 3 5     TBP-Associated Factor 150 KDa2 3
TAFII1502 3 5     MRT402 5
TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, B,
150kD1 2
     Cofactor Of Initiator Function, 150kD Subunit2
Transcription Initiation Factor TFIID 150 KDa Subunit2 3     Transcription Initiation Factor TFIID Subunit 22
150 KDa Cofactor Of Initiator Function2 3     TAFII-1503

External Ids:    HGNC: 115361   Entrez Gene: 68732   Ensembl: ENSG000000643137   OMIM: 6049125   UniProtKB: Q6P1X53   

Export aliases for TAF2 gene to outside databases

Previous GC identifers: GC08M119730 GC08M120749 GC08M120411 GC08M120699 GC08M120812 GC08M116063


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TAF2 Gene:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein
that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to
position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription
complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a
group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal
transcription, serve as coactivators, function in promoter recognition or modify general transcription factors
(GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits
of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of
the transcription initiation site, interactions that help determine transcription complex response to activators.
(provided by RefSeq, Jul 2008)

GeneCards Summary for TAF2 Gene:
TAF2 (TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa) is a protein-coding gene. Diseases associated with TAF2 include mental retardation, autosomal recessive 40. GO annotations related to this gene include metallopeptidase activity and transcription regulatory region DNA binding.

UniProtKB/Swiss-Prot: TAF2_HUMAN, Q6P1X5
Function: Transcription factor TFIID is one of the general factors required for accurate and regulated initiation
by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter
responses to various activators and repressors. It requires core promoter-specific cofactors for productive
transcription stimulation. TAF2 stabilizes TFIID binding to core promoter

Gene Wiki entry for TAF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TAF2 gene promoter:
         STAT1   HOXA3   AML1a   Nkx2-2   STAT1beta   Nkx2-5   GATA-1   STAT1alpha   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAF2 promoter sequence
   Search Chromatin IP Primers for TAF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.12   Ensembl cytogenetic band:  8q24.12   HGNC cytogenetic band: 8q24

TAF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAF2 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M120743:  view genomic region     (about GC identifiers)

Start:
120,743,014 bp from pter      End:
120,845,103 bp from pter
Size:
102,090 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TAF2_HUMAN, Q6P1X5 (See protein sequence)
Recommended Name: Transcription initiation factor TFIID subunit 2  
Size: 1199 amino acids; 136971 Da
Subunit: Component of transcription factor TFIID which is composed of TBP and a number of TBP-associated factors.
Interacts with TAF2C1. Component of the TFTC-HAT complex
Miscellaneous: PubMed:9418870 was unable to show an association between TAF2 and TFIID
Sequence caution: Sequence=AAC68502.1; Type=Erroneous initiation; Sequence=AAH64830.1; Type=Miscellaneous
discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Secondary accessions: B2RE82 O43487 O43604 O60668 Q86WW7 Q8IWK4

Explore the universe of human proteins at neXtProt for TAF2: NX_Q6P1X5

Explore proteomics data for TAF2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TAF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003175.1  
    ENSEMBL proteins: 
     ENSP00000367406   ENSP00000436750   ENSP00000428690   ENSP00000430832   ENSP00000428484  

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    antibodies-online proteins for TAF2 (2 products) 

     
    antibodies-online peptides for TAF2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR014782 Peptidase_M1_N
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q6P1X5

    ProtoNet protein and cluster: Q6P1X5

    1 Blocks protein domain: IPB001930 Membrane alanyl dipeptidase (M1) family signature

    UniProtKB/Swiss-Prot: TAF2_HUMAN, Q6P1X5
    Similarity: Belongs to the TAF2 family


    Find genes that share domains with TAF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAF2_HUMAN, Q6P1X5
    Function: Transcription factor TFIID is one of the general factors required for accurate and regulated initiation
    by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter
    responses to various activators and repressors. It requires core promoter-specific cofactors for productive
    transcription stimulation. TAF2 stabilizes TFIID binding to core promoter

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488binding ----
    GO:0005515protein binding IPI9418870
    GO:0008237metallopeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
    GO:0044212transcription regulatory region DNA binding IMP10409744
         
    Find genes that share ontologies with TAF2           About GenesLikeMe


    Phenotypes:
         5 GenomeRNAi human phenotypes for TAF2:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased viability 
     Decreased viability of wild-ty 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TAF2

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    5 qRT-PCR Assays for microRNAs that regulate TAF2:
    hsa-miR-140-3p hsa-miR-548t hsa-miR-466 hsa-miR-548n hsa-miR-3182
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TAF2_HUMAN, Q6P1X5: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005669colocalizes with transcription factor TFIID complex IDA10409744
    GO:0033276transcription factor TFTC complex IDA10373431

    Find genes that share ontologies with TAF2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TAF2 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Assembly of RNA Polymerase-II Initiation Complex
    Assembly of RNA Polymerase-II Initiation Complex0.91
    Basal transcription factors0.50
    Transcription of mRNA0.91
    Crosstalk Between CARM1 and ESRs0.39
    Protein Acetylation and Deacetylation0.51
    2Apoptotic Pathways in Synovial Fibroblasts
    Nuclear Receptor Activation by Vitamin-A0.57
    3GPCR Pathway
    Estrogen Pathway0.55
    4Androgen Signaling
    Androgen Signaling0.52
    5PEDF Induced Signaling
    Glucocorticoid Receptor Signaling0.43


    Find genes that share SuperPaths with TAF2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TAF2 (see all 8)
        Nuclear Receptor Activation by Vitamin-A
    Protein Acetylation and Deacetylation
    Androgen Signaling
    Glucocorticoid Receptor Signaling
    Estrogen Pathway

    1 GeneGo (Thomson Reuters) Pathway for TAF2
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    1 Kegg Pathway  (Kegg details for TAF2):
        Basal transcription factors

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TAF2
    Interactions:

        GeneGlobe Interaction Network for TAF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TAF2 (Q6P1X53 ENSP000003674064) via UniProtKB, MINT, STRING, and/or I2D (see all 139)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H2BCP628073I2D: score=1 
    HIST1H2BEP628073I2D: score=1 
    HIST1H2BFP628073I2D: score=1 
    HIST1H2BGP628073I2D: score=1 
    HIST1H2BIP628073I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086G2/M transition of mitotic cell cycle IMP10409744
    GO:0006367transcription initiation from RNA polymerase II promoter IDA9418870
    GO:0014070response to organic cyclic compound IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IMP10409744

    Find genes that share ontologies with TAF2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TAF2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TAF2 gene: 
    NM_003184.3  

    Unigene Cluster for TAF2:

    TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
    Hs.122752  [show with all ESTs]
    Unigene Representative Sequence: NM_003184
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378164(uc003you.3) ENST00000529653 ENST00000526969 ENST00000519355
    ENST00000523078 ENST00000523098 ENST00000523904 ENST00000523734 ENST00000521007

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    hsa-miR-140-3p hsa-miR-548t hsa-miR-466 hsa-miR-548n hsa-miR-3182
    SwitchGear 3'UTR luciferase reporter plasmidTAF2 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat TAF2

    Additional mRNA sequence: 

    AF026445.1 AF040701.1 AF057694.1 AK001618.1 AK001909.1 AK316592.1 AL137601.1 BC008473.1 
    BC018010.1 BC035673.2 BC037262.1 BC047732.1 BC064830.1 

    11 DOTS entries:

    DT.210351  DT.95172572  DT.100862526  DT.101976333  DT.120632559  DT.92039731  DT.100643486  DT.102828677 
    DT.91820931  DT.92435446  DT.95172559 

    Selected AceView cDNA sequences (see all 149):

    AI653879 BE645277 CA416456 AA594294 AI373838 BQ427717 AI420493 AK001909 
    AU098502 BF001811 BM974263 AI393239 BQ959501 BX091764 AI990807 AI358531 
    AW963035 AA768610 AL137601 NM_003184 AL040173 AU132255 BC018010 AL035967 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TAF2 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b · 19c ^
    SP1:                                                                                                                                            -               
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                -                                                                                                                           

    ExUns: 20a · 20b ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27 ^ 28a · 28b
    SP1:  -     -                 -                                   -     -                           
    SP2:                          -                                   -     -                           
    SP3:                          -                                                                     
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for TAF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TAF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCTTTAATA
    TAF2 Expression
    About this image


    TAF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             Secondary Spermatocyte Seminiferous Tubules
     
     Gonad
             Secondary Spermatocyte Seminiferous Tubules
    TAF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TAF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.122752

    UniProtKB/Swiss-Prot: TAF2_HUMAN, Q6P1X5
    Tissue specificity: Expressed in all tissues tested

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TAF2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Taf21 , 5 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated more1, 5 88.65(n)1
    95.74(a)1
      15 (21.96 cM)5
    3199441  NM_001081288.11  NP_001074757.11 
     550151295 
    chicken
    (Gallus gallus)
    Aves TAF21 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated more 82.58(n)
    93.64(a)
      428389  XM_003640856.2  XP_003640904.2 
    lizard
    (Anolis carolinensis)
    Reptilia TAF26
    TAF2 RNA polymerase II, TATA box binding protein (...
    90(a)
    1 ↔ 1
    GL343269.1(1045853-1095419)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.323722 Xenopus laevis transcribed sequence with moderate similarity more 78.73(n)    BJ615523.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BU710501.12   -- 76.28(n)   325123  BU710501.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Taf21 , 3 transcription initiation from Pol II
    promoter more3
    TBP-associated factor 21
    52(a)3
    53.75(n)1
    53.68(a)1
      3 67D13
    391641  NM_168387.31  NP_729571.11 
    worm
    (Caenorhabditis elegans)
    Secernentea taf-21 , 3 TATA binding protein associated factor3
    taf-21
    32(a)3
    45.32(n)1
    34.49(a)1
      IV(3584735-3593599)3
    1920511  NM_067977.31  NP_500378.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TAF26
    TFIID subunit (150 kDa), involved in RNA polymeras...
    19(a)
    1 ↔ 1
    III(201174-205397) YCR042C


    ENSEMBL Gene Tree for TAF2 (if available)
    TreeFam Gene Tree for TAF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TAF2 gene
    Selected SIMAP similar genes for TAF2 using alignment to 5 protein entries:     TAF2_HUMAN (see all proteins) (see all similar genes):
    C1orf143    EIF3K    CALCOCO2    DUSP3    HINFP    GALK2
    IK    EEF1E1    EIF3G    SLC35E3    ARL6IP5    PUS1
    LSM12    NDUFS3    SLC24A1    ABI2    PFKFB3    SH2B3

    Find genes that share paralogs with TAF2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for TAF2 (see all 1958)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1491829271,2
    --120742673(+) AAATAA/GTTTCA 1 -- ds50010--------
    rs1837777041,2
    --120742795(+) ATTCCC/TGAATA 1 -- ds50010--------
    rs793795051,2
    F--120742894(+) CTAGTG/CAGGCC 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs1887587581,2
    --120742898(+) TGAGGC/GCAGCT 1 -- ds50010--------
    rs1932922281,2
    --120743127(+) AAAAAC/TTGAAC 1 -- ut310--------
    rs1849556471,2
    --120743224(+) ATTTCA/GTATGT 1 -- ut310--------
    rs1433544511,2
    C--120743363(+) GGTGTA/GTAAAT 1 -- ut310--------
    rs1881054601,2
    --120743516(+) TAACCA/GCCGAA 1 -- ut310--------
    rs1915157301,2
    C--120743537(+) AAAGAC/TAGTTA 1 -- ut310--------
    rs1840318091,2
    --120743663(+) AAAATC/GGTGCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TAF2 (120743014 - 120845103 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for TAF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2310118CNV Deletion18987734
    esv2485427CNV Deletion19546169
    esv2678251CNV Deletion23128226
    esv268830CNV Insertion20981092
    esv273446CNV Insertion20981092
    nsv510171CNV Loss20534489
    esv25627CNV Loss19812545
    nsv891418CNV Gain21882294

    Human Gene Mutation Database (HGMD): TAF2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TAF2
    DNA2.0 Custom Variant and Variant Library Synthesis for TAF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604912   
    OMIM disorders: 615599  
    1 disease for TAF2:    
    About MalaCards
    mental retardation, autosomal recessive 40


    Find genes that share disorders with TAF2           About GenesLikeMe


    Export disorders for TAF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TAF2 gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with TAF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel cofactors and TFIIA mediate functional core promoter selectivity by the human TAFII150-containing TFIID complex. (PubMed id 9774672)1, 2, 3 Martinez E.... Roeder R.G. (Mol. Cell. Biol. 1998)
    2. CIF150, a human cofactor for transcription factor IID-dependent initiator function. (PubMed id 9418870)1, 2, 3 Kaufmann J.... Muller R. (Mol. Cell. Biol. 1998)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one- dimensional gel electrophoresis. (PubMed id 12601814)1, 2 Cavusoglu N.... van Dorsselaer A. (Proteomics 2003)
    6. The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells. (PubMed id 23667531)1 Cox J.L....Rizzino A. (PLoS ONE 2013)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    8. Human mediator subunit MED26 functions as a docking site for transcription elongation factors. (PubMed id 21729782)1 Takahashi H....Conaway J.W. (Cell 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6873 HGNC: 11536 AceView: TAF2 Ensembl:ENSG00000064313 euGenes: HUgn6873
    ECgene: TAF2 Kegg: 6873 H-InvDB: TAF2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TAF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TAF2 gene:
    Search GeneIP for patents involving TAF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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