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Aliases for TAF1L Gene

Aliases for TAF1L Gene

  • TATA-Box Binding Protein Associated Factor 1 Like 2 3 5
  • TAF1 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 210kDa-Like 2 3
  • Transcription Initiation Factor TFIID 210 KDa Subunit 3 4
  • TBP-Associated Factor 210 KDa 3 4
  • TBP-Associated Factor 1-Like 3 4
  • TAF(II)210 3 4
  • TAF1-Like RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 210kDa 2
  • TBP-Associated Factor RNA Polymerase 1-Like 3
  • EC 2.7.11.1 63
  • EC 2.7.11 63
  • TAF2A2 3

External Ids for TAF1L Gene

Previous GeneCards Identifiers for TAF1L Gene

  • GC09M032798

Summaries for TAF1L Gene

Entrez Gene Summary for TAF1L Gene

  • This locus is intronless, and apparently arose in the primate lineage from retrotransposition of the transcript from the multi-exon TAF1 locus on the X chromosome. The gene is expressed in male germ cells, and the product has been shown to function interchangeably with the TAF1 product. [provided by RefSeq, Aug 2015]

GeneCards Summary for TAF1L Gene

TAF1L (TATA-Box Binding Protein Associated Factor 1 Like) is a Protein Coding gene. Among its related pathways are Gene Expression and HIV Life Cycle. GO annotations related to this gene include protein serine/threonine kinase activity and TBP-class protein binding. An important paralog of this gene is TAF1.

UniProtKB/Swiss-Prot for TAF1L Gene

  • May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF1L Gene

Genomics for TAF1L Gene

Regulatory Elements for TAF1L Gene

Genomic Location for TAF1L Gene

Chromosome:
9
Start:
32,629,454 bp from pter
End:
32,635,669 bp from pter
Size:
6,216 bases
Orientation:
Minus strand

Genomic View for TAF1L Gene

Genes around TAF1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF1L Gene

Proteins for TAF1L Gene

  • Protein details for TAF1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZX4-TAF1L_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 1-like
    Protein Accession:
    Q8IZX4
    Secondary Accessions:
    • Q0VG57

    Protein attributes for TAF1L Gene

    Size:
    1826 amino acids
    Molecular mass:
    207302 Da
    Quaternary structure:
    • Can bind directly to TATA-box binding protein (TBP). Interacts (via bromo domains) with acetylated lysine residues on the N-terminus of histone H1.4, H2A, H2B, H3 and H4 (in vitro).

    Three dimensional structures from OCA and Proteopedia for TAF1L Gene

neXtProt entry for TAF1L Gene

Proteomics data for TAF1L Gene at MOPED

Post-translational modifications for TAF1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAF1L Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for TAF1L Gene

Protein Domains for TAF1L Gene

Suggested Antigen Peptide Sequences for TAF1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IZX4

UniProtKB/Swiss-Prot:

TAF1L_HUMAN :
  • Contains 2 bromo domains.
  • Belongs to the TAF1 family.
Domain:
  • Contains 2 bromo domains.
Family:
  • Belongs to the TAF1 family.
genes like me logo Genes that share domains with TAF1L: view

Function for TAF1L Gene

Molecular function for TAF1L Gene

UniProtKB/Swiss-Prot Function:
May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced.

Enzyme Numbers (IUBMB) for TAF1L Gene

Gene Ontology (GO) - Molecular Function for TAF1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity ISS 12217962
genes like me logo Genes that share ontologies with TAF1L: view
genes like me logo Genes that share phenotypes with TAF1L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TAF1L Gene

Localization for TAF1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF1L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAF1L Gene COMPARTMENTS Subcellular localization image for TAF1L gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TAF1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005669 transcription factor TFIID complex IEA --
genes like me logo Genes that share ontologies with TAF1L: view

Pathways & Interactions for TAF1L Gene

genes like me logo Genes that share pathways with TAF1L: view

Gene Ontology (GO) - Biological Process for TAF1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IDA 12217962
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0016032 viral process TAS --
genes like me logo Genes that share ontologies with TAF1L: view

No data available for SIGNOR curated interactions for TAF1L Gene

Drugs & Compounds for TAF1L Gene

No Compound Related Data Available

Transcripts for TAF1L Gene

mRNA/cDNA for TAF1L Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAF1L Gene

TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAF1L Gene

No ASD Table

Relevant External Links for TAF1L Gene

GeneLoc Exon Structure for
TAF1L
ECgene alternative splicing isoforms for
TAF1L

Expression for TAF1L Gene

mRNA expression in normal human tissues for TAF1L Gene

mRNA differential expression in normal tissues according to GTEx for TAF1L Gene

This gene is overexpressed in Testis (x22.1).

Protein differential expression in normal tissues from HIPED for TAF1L Gene

This gene is overexpressed in Heart (34.9), Urine (18.5), and Peripheral blood mononuclear cells (15.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAF1L Gene



SOURCE GeneReport for Unigene cluster for TAF1L Gene Hs.591086

mRNA Expression by UniProt/SwissProt for TAF1L Gene

Q8IZX4-TAF1L_HUMAN
Tissue specificity: Testis specific, expressed apparently in germ cells.
genes like me logo Genes that share expression patterns with TAF1L: view

Protein tissue co-expression partners for TAF1L Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TAF1L Gene

Orthologs for TAF1L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAF1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF1L 35
  • 99.03 (n)
  • 98.36 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 88 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 88 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Taf1 36
  • 85 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 79 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 81 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 78 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii taf1 36
  • 71 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Taf1 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea taf-1 36
  • 35 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF1 36
  • 26 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2050 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 63 (a)
OneToMany
Species with no ortholog for TAF1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TAF1L Gene

ENSEMBL:
Gene Tree for TAF1L (if available)
TreeFam:
Gene Tree for TAF1L (if available)

Paralogs for TAF1L Gene

Paralogs for TAF1L Gene

(1) SIMAP similar genes for TAF1L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TAF1L: view

Variants for TAF1L Gene

Sequence variations from dbSNP and Humsavar for TAF1L Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_041934 A lung small cell carcinoma sample
rs56352331 - 32,635,069(+) ATCTT(A/C/G)GTCCT reference, missense
rs55991718 - 32,634,813(+) CTTTT(C/G)CAGGT reference, missense
rs17219559 - 32,634,469(+) CAGCA(C/T)ATCAT reference, missense
rs56128445 - 32,633,985(+) CAGGA(A/T)TTTCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TAF1L Gene

Variant ID Type Subtype PubMed ID
nsv831540 CNV Gain 17160897
nsv893012 CNV Gain 21882294
esv24966 CNV Gain 19812545

Variation tolerance for TAF1L Gene

Residual Variation Intolerance Score: 90.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.05; 68.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAF1L Gene

HapMap Linkage Disequilibrium report
TAF1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF1L Gene

Disorders for TAF1L Gene

Relevant External Links for TAF1L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAF1L

No disorders were found for TAF1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAF1L Gene

Publications for TAF1L Gene

  1. Functional substitution for TAF(II)250 by a retroposed homolog that is expressed in human spermatogenesis. (PMID: 12217962) Wang P.J. … Page D.C. (Hum. Mol. Genet. 2002) 2 3 4 23 67
  2. A meta-analysis of somatic mutations from next generation sequencing of 241 melanomas: a road map for the study of genes with potential clinical relevance. (PMID: 24755198) Xia J. … Zhao Z. (Mol. Cancer Ther. 2014) 3
  3. Whole transcriptome sequencing identifies tumor-specific mutations in human oral squamous cell carcinoma. (PMID: 24007313) Zhang Q. … Sheng S. (BMC Med Genomics 2013) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed. (PMID: 22658931) Pajewski N.M. … Kaslow R.A. (Vaccine 2012) 3

Products for TAF1L Gene

Sources for TAF1L Gene

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