TAF1L Gene
protein-coding GIFtS: 54
GCID: GC09M032619
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TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated...(Previous names: TAF1-like RNA polymerase II, TATA box binding protein (TBP)-associated...)
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Aliases
for TAF1L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TAF1 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor,210kDa-Like1 2 | | TAF2A22 | | Transcription Initiation Factor TFIID 210 KDa Subunit2 3 | | TBP-Associated Factor RNA Polymerase 1-Like2 | | TAF(II)2102 3 | | Transcription Initiation Factor TFIID Subunit 1-Like2 | | TBP-Associated Factor 1-Like2 3 | | EC 2.7.118 | | TBP-Associated Factor 210 KDa2 3 | | EC 2.7.11.18 | | TAF1-Like RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor,210kDa1 | | |
Export aliases for TAF1L gene to outside databasesPrevious GC identifer: GC09M032798 |
Summaries
for TAF1L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TAF1L:
This locus is intronless, and apparently arose in the primate lineage from retrotransposition of the transcript fromthe multi-exon TAF1 locus on the X chromosome. The gene is expressed in male germ cells, and the product has beenshown to function interchangeably with the TAF1 product. (provided by RefSeq, Aug 2009)
UniProtKB/Swiss-Prot: TAF1L_HUMAN, Q8IZX4Function: May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes aretranscriptionally silenced
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Genomic Views
for TAF1L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TAF1L gene promoter:
Max1 TBP Elk-1 GATA-3 MZF-1 TFIID IRF-7A c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for TAF1L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAF1L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p21.1 Ensembl cytogenetic band: 9p21.1 HGNC cytogenetic band: 9p12TAF1L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M032619: view genomic region
(about GC identifiers)
Start:
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32,629,452 bp from pter |
End:
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32,635,667 bp from pter |
Size:
|
6,216 bases |
Orientation:
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minus strand |
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Proteins
for TAF1L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TAF1L_HUMAN, Q8IZX4 (See
protein sequence)Recommended Name: Transcription initiation factor TFIID subunit 1-like Size: 1826 amino acids; 207302 Da
Subunit: Can bind directly to TATA-box binding protein (TBP). Interacts (via bromo domains) with acetylated lysineresidues on the N-terminus of histone H1.4, H2A, H2B, H3 and H4 (in vitro)
Subcellular location: Nucleus (By similarity)
1 PDB 3D structure from  and Proteopedia  for TAF1L:3HMH (3D)
Secondary accessions: Q0VG57Explore the universe of human proteins at neXtProt for TAF1L: NX_Q8IZX4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IZX4
4/17 DME Specific Peptides for TAF1L (Q8IZX4) (see all 17)
TAF1L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_722516.1
ENSEMBL proteins: ENSP00000418379
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0005669 | transcription factor TFIID complex |
IEA | -- |
TAF1L for ontologies About GeneDecksing
TAF1L Antibody Products:
Assay Products for TAF1L: |
Protein
Domains /
Families
for TAF1L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TAF1L for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IZX4ProtoNet protein and cluster: Q8IZX4 1 Blocks protein family: IPB001487 Bromodomain signature
UniProtKB/Swiss-Prot: TAF1L_HUMAN, Q8IZX4Similarity: Belongs to the TAF1 familySimilarity: Contains 2 bromo domains |
Function
for TAF1L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TAF1L_HUMAN, Q8IZX4Function: May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes aretranscriptionally silencedEnzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.12
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAF1L
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF1L |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
TAF1L for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for TAF1L:
|
Pathways & Interactions
for TAF1L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Assembly of RNA Polymerase-II Initiation Complex | | | 2 | Apoptotic Pathways in Synovial Fibroblasts | | | 3 | GPCR Pathway | | | 4 | PEDF Induced Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TAF1L (see all 7)
1 
Kegg Pathway (Kegg details for TAF1L):
TAF1L for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TAF1L
STRING Interaction
Network Preview (showing 5 interactants - click image to see 23)
5/25 Interacting proteins for TAF1L (Q8IZX42, 3 ENSP000004183794) via UniProtKB, MINT, STRING, and/or I2D (see all 25)About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table
TAF1L for ontologies About GeneDecksing
|
Drugs & Compounds
for TAF1L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TAF1L
Search CenterWatch for drugs/clinical trials and news about TAF1L
|
Transcripts
for TAF1L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TAF1L gene: NM_153809.2 Unigene Cluster for TAF1L: TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like Hs.591086 [show with all ESTs]Unigene Representative Sequence: AF3905621 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000242310(uc003zrg.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAF1L
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAF1L
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TAF1L (NM_153809) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAF1L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAF1L |
Additional cDNA sequence: AF390562.1 AK091653.1 BC116181.1 BC116182.1 6 DOTS entries: DT.100813410 DT.99934064 DT.97839287 DT.100813411 DT.121285810 DT.208635 2 AceView cDNA sequences: NM_153809 AF390562
GeneLoc Exon Structure
|
Expression
for TAF1L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TAF1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTATCATCTC
About this image
See TAF1L Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TAF1L
SOURCE GeneReport for Unigene cluster: Hs.591086
UniProtKB/Swiss-Prot: TAF1L_HUMAN, Q8IZX4Tissue specificity: Testis specific, expressed apparently in germ cells
SABiosciences Custom PCR Arrays for TAF1L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAF1L
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF1L |
Orthologs
for TAF1L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TAF1L gene from 7/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TAF16 |
Uncharacterized protein |
81(a) |
1 → many |
4(2201431-2229775) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
79(a) |
possible ortholog |
GL343599.1(27628-60414) |
zebrafish
(Danio rerio) |
Actinopterygii |
taf16 |
TAF1 RNA polymerase II, TATA box binding protein (... |
70(a) |
1 → many |
5(38151633-38192557) |
fruit fly
(Drosophila melanogaster) |
Insecta |
Taf16 |
TBP-associated factor 1 |
39(a) |
1 → many |
3R(2472611-2481770) |
worm
(Caenorhabditis elegans) |
Secernentea |
taf-16 |
TAF (TBP-associated transcription factor) family m... |
33(a) |
1 → many |
I(13861456-13887641) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
HAF016TAF1B6 |
transcription initiation factor TFIID subunit 1-B |
18(a)17(a) |
many ↔ manymany ↔ many |
1(11846247-11856765) 3(6567157-6575282) |
rice
(Oryza sativa) |
Liliopsida |
-- |
transcription initiation factor TFIID subunit 1, p... |
19(a) |
1 → many |
6(26359284-26373493) |
Species with no ortholog for TAF1L
ENSEMBL Gene Tree for TAF1L (if available)
TreeFam Gene Tree for TAF1L (if available) |
Paralogs
for TAF1L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TAF1L gene
- TAF12
3 SIMAP similar genes for TAF1L using alignment to 1 protein entry: TAF1L_HUMAN:DYT3 N-TAF1 TAF1
TAF1L for paralogs About GeneDecksing
|
Genomic Variants
for TAF1L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TAF1L (32629452 - 32635667 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TAF1L
1 CNV: 70536
Human Gene Mutation Database (HGMD): TAF1L
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAF1L |
|
Disorders
/ Diseases
for TAF1L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TAF1L for disorders About GeneDecksing
OMIM gene information: 607798
OMIM disorders: --
1  disease for TAF1L: About MalaCardsfamilial dystonia
1 disease from the University of Copenhagen DISEASES database for TAF1L:Familial dystonia Export disorders for TAF1L gene to outside databases
|
Publications
for TAF1L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TAF1L gene integrated from 9 sources:
(articles sorted by number of sources associating them with TAF1L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Functional substitution for TAF(II)250 by a retroposed homolog that is expressed in human spermatogenesis. (PubMed id 12217962)1, 2, 3, 9 Wang P.J. and Page D.C. (2002)
- A genome-wide association study of host genetic determ inants of the antibody response to Anthrax Vaccine Adsorbed. (PubMed id 22658931)1 Pajewski N.M....Kaslow R.A. (2012)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Histone recognition and large-scale structural analysis of the human bromodomain family. (PubMed id 22464331)2 Filippakopoulos P.... Knapp S. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. (PubMed id 17643375)1 Jeronimo C.... Coulombe B. (2007)
- Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TAF1L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TAF1L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TAF1L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TAF1L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TAF1L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TAF1L gene:
Search GeneIP for patents involving TAF1L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TAF1L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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