V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

TAF1L Gene

protein-coding GIFtS: 51

GC09M032619

TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like
(Previous names: TAF1-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGC134910 ^²
TAF(II)210 ^³
TAF2A2 ^²

Descriptions
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like ^²
TAF1 RNA polymerase II, TATA box binding protein-associated factor, 210kDa-like ^¹
TAF1-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210 kD ^²
TAF1-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa ^¹, ²
TBP-associated factor 1-like ^³
TBP-associated factor 210 kDa ^³
TBP-associated factor RNA polymerase 1-like ^²

External Ids
HGNC: 18056¹
Entrez Gene: 138474²
UniProtKB: Q8IZX4³
Ensembl: ENSG00000122728⁷

Search outside databases for aliases for TAF1L gene

Previous GC identifer: GC09M032798

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: TAF1L_HUMAN, Q8IZX4

Function: May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex

chromosomes are transcriptionally silenced

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TAF1L gene

Entrez Gene cytogenetic band: 9p21.1 Ensembl cytogenetic band: 9p21.1 HGNC cytogenetic band: 9p12

TAF1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M032619: (about GC identifiers)

Start:	32,619,452 bp from pter
End:	32,625,667 bp from pter
Size:	6,216 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000009.10 NT_008413.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TAF1L_HUMAN, Q8IZX4 (See protein sequence)

Recommended Name: Transcription initiation factor TFIID 210 kDa subunit

Size: 1826 amino acids; 207302 Da

Subunit: Can bind directly to TATA-box binding protein (TBP)

Subcellular location: Nucleus (By similarity)

Secondary accessions: Q0VG57

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_722516.1

ENSEMBL proteins:

ENSP00000242310

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich AQUA Peptides for TAF1L
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (TAF1L)
	Human Recombinant Proteins from Abnova (TAF1L)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005669	transcription factor TFIID complex	IEA	--

About this table

Antibodies for TAF1L:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for TAF1L
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (TAF1L), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TAF1L)
	Novus Biologicals Antibody for TAF1L

Assays for TAF1L:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8IZX4

ProtoNet protein and cluster: Q8IZX4

1 Blocks protein family: IPB001487 Bromodomain signature

UniProtKB/Swiss-Prot: TAF1L_HUMAN, Q8IZX4

Similarity: Belongs to the TAF1 family

Similarity: Contains 2 bromo domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TAF1L)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TAF1L)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_153809

Applied Biosystems Silencer® siRNAs for TAF1L

Sigma-Aldrich siRNA and siRNA Panels for TAF1L

Sigma-Aldrich shRNA Panels and shRNA for TAF1L

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_153809
Myc/DDK tagged cDNA clone in CMV expression vector: NM_153809
untagged cDNA clone in CMV expression vector: NM_153809

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_153809

UniProtKB/Swiss-Prot: TAF1L_HUMAN, Q8IZX4

Function: May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex

chromosomes are transcriptionally silenced

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0004402	histone acetyltransferase activity	ISS	12217962
GO:0004674	protein serine/threonine kinase activity	ISS	12217962
GO:0016563	transcription activator activity	IDA	12217962
GO:0017025	TATA-binding protein binding	IPI	12217962

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for TAF1L (Your Favorite Gene powered by Ingenuity)

Estrogen Receptor Signaling
Glucocorticoid Receptor Signaling

GeneDecks TAF1L for the pathways selected above

About GeneDecksing

1 Interacting protein for TAF1L (ENSP00000242310³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TBP	ENSP00000230354³	STRING (score=.984)

About this table

5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006350	transcription	IEA	--
GO:0006352	transcription initiation	IEA	--
GO:0006357	regulation of transcription from RNA polymerase II promoter	IDA	12217962
GO:0007049	cell cycle	IEA	--
GO:0007140	male meiosis	IEP	12217962

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TAF1L

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TAF1L)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TAF1L)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_153809

Sigma-Aldrich siRNA and siRNA Panels for TAF1L

Sigma-Aldrich shRNA Panels and shRNA for TAF1L

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_153809

REFSEQ mRNAs for TAF1L gene:

NM_153809.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_153809

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_153809
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_153809
                                 untagged cDNA clone in CMV expression vector: NM_153809

Additional cDNA sequence:

AF390562.1 AK091653.1 BC116181.1 BC116182.1

5 DOTS entries:

DT.100813410 DT.99934064 DT.97839287 DT.100813411 DT.208635

2 AceView cDNA sequences:

NM_153809 AF390562

highest scoring ESTs for TAF1L:

AF390562 NM_153809 BC116181 BC116182 DA519710 AI150283 AK091653 AW882952 BF765488

Unigene Cluster for TAF1L:

TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like

Hs.591086 [show with all ESTs]

Unigene Representative Sequence: AF390562

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000242310

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TAF1L expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TAF1L

¹ / ² / ³

2 probe-sets matching TAF1L gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
112_g_at²^{, 3}	U95-A	2	0.94	0.47	1.00	1.00	X07024	0.20	0.17	0.18	2
1553011_at²	U133Plus2	2	1.00	0.82	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTATCATCTC

SOURCE GeneReport for Unigene cluster: Hs.591086
UniProtKB/Swiss-Prot: TAF1L_HUMAN, Q8IZX4
Tissue specificity: Testis specific, expressed apparently in germ cells

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for TAF1L gene from 1 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
sea squirt (Ciona intestinalis)	Cin.2050²	--	Ciona intestinalis transcribed sequence with weak more	77.76(n)	BW203877.1

About this table Species with no ortholog for TAF1L

ENSEMBL Gene Tree for TAF1L

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for TAF1L gene

TAF1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/54 NCBI SNPs in TAF1L are shown (see all 54 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 23)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs10971046^1,2	C,F,H	32619645(+)	`GATGAT/CACCAT`	1	--	ut3¹		4		EU EA WA	420
	rs16918393^1,2	C,F,H	32620165(+)	`TCTTAT/CTCCAC`	1	V/I	mis¹		11		NA EU EA WA	980
	rs17219559^1,2	C,F,H	32624467(+)	`CAGCAT/CATCAT`	1	V/M	mis¹		11		NA EU EA WA	980
--	rs1258^1,2	C,F	32623119(+)	`TATGCA/GTATTG`	1	M/T	mis¹ ese³		1		MN	184
--	rs10813844^1,2	A	32625771(+)	`GGCGCA/GATCTT`	1	--	ng3¹		0	--	--	--	--
--	rs35905429^1,2	C	32622532(+)	`AAGGCA/GACGAA`	1	R/C	mis¹		0	--	--	--	--
--	rs589388^1,2	H	32626475(+)	`ctggtC/Gttaaa`	1	--	ng3¹		4		EU EA WA	420
--	rs10758145^1,2	A,C,F,H	32620472(+)	`ATCTGT/CTTTTC`	1	K/K	syn¹		11		NA EU EA WA	972
	rs10971047^1,2	C,F,H	32621369(+)	`GACAGC/TGTCAC`	1	T/T	syn¹ ese³		4		EU EA WA	412
	rs16918395^1,2	H	32625317(+)	`GTCCCA/GGTCAA`	1	T/T	syn¹ ese³		7		NA EU EA WA	556

About this table

HapMap Linkage Disequilibrium images for TAF1L (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 607798

Human Gene Mutation Database: TAF1L

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

4 PubMed articles for TAF1L gene:

Functional substitution for TAF(II)250 by a retroposed homolog that is expressed in human spermatogenesis. (PubMed id 12217962)^{1, 2, 3, 4} Wang P.J. and Page D.C. (2002)
Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)⁴ Greenman C.... Stratton M.R. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)³ Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 138474	HGNC: 18056	AceView: TAF1L	Ensembl:ENSG00000122728	euGenes: HUgn138474
ECgene: TAF1L	H-InvDB: TAF1L

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for TAF1L
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TAF1L:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TAF1L-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TAF1L		Antibodies for TAF1L
	Explore super-pooled esiRNAs		Proteins for TAF1L
	Lentivirus-delivered shRNAs for TAF1L		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TAF1L)
	Antibodies (TAF1L)
	Chimera RNAi (TAF1L)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (TAF1L)
	Antibodies (TAF1L)

Search OriGene for TAF1L

Search Tocris compounds for TAF1L

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TAF1L

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
TAF1L Gene at Home site.
Version 2.41.1
server4.xennexinc.com

TAF1L Gene

protein-coding GIFtS: 51

Aliases &
Descriptions
for TAF1L

Summaries
for TAF1L

Genomic Location
for TAF1L

Proteins
for TAF1L

Protein Domains/
Families
for TAF1L

Gene Function
for TAF1L

Pathways & Interactions
for TAF1L

Drugs & Compounds
for TAF1L

Transcripts
for TAF1L

Expression
for TAF1L

Orthologs
for TAF1L

Paralogs
for TAF1L

SNPs/Variants
for TAF1L

Disorders & Mutations
for TAF1L

Medical News
for TAF1L

Publications
for TAF1L

Search for TAF1L

Genome Databases showing TAF1L

Other Databases showing TAF1L

Specialized Databases showing TAF1L

Licensable Technologies
for TAF1L

Services
for TAF1L

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TAF1L Gene

protein-coding GIFtS: 51

Aliases & Descriptionsfor TAF1L

Summariesfor TAF1L

Genomic Locationfor TAF1L

Proteinsfor TAF1L

Protein Domains/Familiesfor TAF1L

Gene Functionfor TAF1L

Pathways & Interactionsfor TAF1L

Drugs & Compoundsfor TAF1L

Transcriptsfor TAF1L

Expression for TAF1L

Orthologsfor TAF1L

Paralogsfor TAF1L

SNPs/Variantsfor TAF1L

Disorders & Mutationsfor TAF1L

Medical Newsfor TAF1L

Publicationsfor TAF1L

Search for TAF1L

Genome Databases showing TAF1L

Other Databases showing TAF1L

Specialized Databases showing TAF1L

Licensable Technologiesfor TAF1L

Servicesfor TAF1L

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TAF1L

Summaries
for TAF1L

Genomic Location
for TAF1L

Proteins
for TAF1L

Protein Domains/
Families
for TAF1L

Gene Function
for TAF1L

Pathways & Interactions
for TAF1L

Drugs & Compounds
for TAF1L

Transcripts
for TAF1L

Expression
for TAF1L

Orthologs
for TAF1L

Paralogs
for TAF1L

SNPs/Variants
for TAF1L

Disorders & Mutations
for TAF1L

Medical News
for TAF1L

Publications
for TAF1L

Licensable Technologies
for TAF1L

Services
for TAF1L