TAF1C Gene
protein-coding GIFtS : 53
GC16M082768
TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa (Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kD )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases & Descriptions for TAF1C
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases MGC:39976 1 , 2 SL1 1 , 2 , 5 TAFI110 1 , 2 , 3 , 5 TAFI95 1 , 2
Descriptions SL1, 110kD subunit 2 TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kD 1 TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa 2 TATA box binding protein-associated factor, RNA polymerase I, C, 110kDa 1 TATA box-binding protein-associated factor 1C 3 TBP-associated factor 1C 2 , 3 TBP-associated factor RNA polymerase I 110 kDa 3 transcription factor SL1 2
Search outside databases for aliases for TAF1C genePrevious GC identifers: GC16M075062 GC16M085178 GC16M083950 GC16M083991
Summaries for TAF1C (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for TAF1C : Initiation of transcription by RNA polymerase I requires the formation of a complex composed of theTATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I.This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position thepolymerase properly and acts as a channel for regulatory signals. This gene encodes the largestSL1-specific TAF. Two transcripts encoding different isoforms have been identified. [provided byRefSeq] UniProtKB/Swiss-Prot: TAF1C_HUMAN, Q15572 Function : Component of the transcription factor SL1/TIFIB complex involved in the assembly of thePIC (preinitiation complex). Recruits RNA polymerase I to the rRNA gene promoter via interactionwith RRN3
Gene Wiki entry for TAF1C
Genomic Location for TAF1C
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the TAF1C gene Entrez Gene cytogenetic band: 16q24 Ensembl cytogenetic band: 16q24.1 HGNC cytogenetic band: 16q24 TAF1C Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure
GeneLoc location for GC16M082768:
(about GC identifiers )
Start:
82,768,962 bp from pter
End:
82,778,163 bp from pter
Size:
9,202 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000016.8 NT_010498.15 Proteins for TAF1C
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: TAF1C_HUMAN, Q15572 (See
protein sequence )Recommended Name: TATA box-binding protein-associated factor RNA polymerase I subunit C Size : 869 amino acids; 95274 Da
Subunit : Component of the transcription factor SL1/TIFIB complex, composed of TBP and at leastTAF1A, TAF1B and TAF1C. In the complex interacts directly with TBP, TAF1A and TAF1B. Interactionof the SL1/TIFIB subunits with TBP excluded interaction with the transcription factor IID (TFIID)subunits. Interacts with MYC, RRN3 and p53/TP53 with low affinity
Subcellular location : Nucleus
Secondary accessions : Q59F67 Q8N6V3Alternative splicing : 3 isoforms : Q15572-1 Q15572-2 Q15572-3
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_005670.2 NP_647610.1 ENSEMBL proteins: ENSP00000367802 ENSP00000345305 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for TAF1C: Assays for TAF1C:
Protein
Domains/ Families for TAF1C(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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ProtoNet protein and cluster: Q15572
Gene Function for TAF1C
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_005679 Applied Biosystems Silencer ® siRNAs for TAF1C Sigma-Aldrich siRNA for TAF1C Sigma-Aldrich shRNA for TAF1C Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_005679                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_005679                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_005679  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005679 UniProtKB/Swiss-Prot: TAF1C_HUMAN, Q15572 Function : Component of the transcription factor SL1/TIFIB complex involved in the assembly of thePIC (preinitiation complex). Recruits RNA polymerase I to the rRNA gene promoter via interactionwith RRN3
3 Gene Ontology (GO) molecular function terms (links to tree view) :
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Pathways & Interactions for TAF1C
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for TAF1C 4 Interacting proteins for TAF1C (Q15572 2 ) via UniProtKB, MINT, and/or STRING About this table 3 Gene Ontology (GO) biological process terms (links to tree view) :
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Drugs & Compounds for TAF1C (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for TAF1C 1 Novoseek chemical compound relationship for TAF1C gene
Compound
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
rrna
59.92
4
16033979 (1), 8609157 (1), 17251981 (1)
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Transcripts for TAF1C(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_005679 Sigma-Aldrich siRNA for TAF1C Sigma-Aldrich shRNA for TAF1C Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_005679 NM_139353
REFSEQ mRNAs for TAF1C gene (2 alternative transcripts): NM_005679.2 NM_139353.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005679 NM_139353
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_005679                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_005679                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_005679  
Additional cDNA sequence: AB209594.1 AK097031.1 AK299060.1 AK299347.1 AK304261.1 AK304739.1 AK315982.1 BC028131.1 CR605319.1 L39059.1
18 DOTS entries : DT.91756320 DT.100817177 DT.75136465 DT.95156013 DT.75157385 DT.91756310 DT.120706095 DT.97780383 DT.95081649 DT.120706113 DT.75128266 DT.75154881 DT.95214266 DT.100033064 DT.100708171 DT.120706057 DT.99945102 DT.95179571
24/169 AceView cDNA sequences (see all 169
):CR605319 BM717341 CA397963 BQ186774 CB305726 CA454870 AI312042 BX350449 BQ928487 BQ448038 CA397964 AW269860 AW236473 AI559694 AI968459 AA641432 CA389989 AI963810 AI361690 NM_005679 BM976286 AW590905 NM_139353 BU857614
highest scoring ESTs for TAF1C :L39059 AK097031 AU130229 BC028131 BG911495 BI767277 BI772171 CB959796 CB990473 CB992993
Unigene Cluster for TAF1C: TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa Hs.153022 [show with all ESTs ] Unigene Representative Sequence: AB209594 GeneLoc Exon Structure 5/18 Alternative Splicing Database (ASD) splice patterns (SP) for TAF1C (see all 18
) ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · SP1 :             -   -   -   -   -   -                             -   SP2 :             -   -         -                               SP3 :             -           -           -   -   -   -   -   -   -   -   -   -   SP4 :             -           -                               SP5 :             -   -         -                              
ExUns: 11b · 11c ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b SP1 : -           -   -                 SP2 :                             SP3 : -                             SP4 :                             SP5 :                            
About this scheme ECgene alternative splicing isoforms for TAF1C 2 Ensembl transcripts including schematic representations : ENST00000378541
ENST00000341690
Expression for TAF1C
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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TAF1C expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for TAF1C 1 / 2 / 3
5 probe-sets matching TAF1C gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CCTAAGGGAGSOURCE GeneReport for Unigene cluster: Hs.153022 Expression variation in blood from EXPOLDB for TAF1C
Orthologs for TAF1C
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for TAF1C gene from 5/6 species (see all 6
)
About this table Species with no ortholog for TAF1C ENSEMBL Gene Tree for TAF1C Paralogs for TAF1C (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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SNPs/Variants for TAF1C (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for TAF1C (up to first 250kb)
Disorders & Mutations for TAF1C
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 604905
Medical News for TAF1C (Possibly Related Articles in
Doctor's Guide )
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Publications for TAF1C (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/42 PubMed articles for TAF1C gene (see all 42
): Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits. (PubMed id 7801123) 2, 3, 4 Comai L....Tjian R. (1994) c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I. (PubMed id 15723054) 3, 4 Grandori C.... White R.J. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters. (PubMed id 11250903) 3, 4 Miller G....Zomerdijk J.C. (2001) Repression of RNA polymerase I transcription by the tumor suppressor p53. (PubMed id 10913176) 3, 4 Zhai W. and Comai L. (2000) Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1. (PubMed id 10894955) 1, 3 Di Pietro C....Purrello M. (2000) PTEN represses RNA Polymerase I transcription by disrupting the SL1 complex. (PubMed id 16055704) 1, 3 Zhang C....Johnson D.L. (2005) Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter. (PubMed id 12393749) 1, 3 Yuan X.... Grummt I. (2002) Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336) 4 Cantin G.T....Yates J.R. III (2008) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332) 4 Matsuoka S.... Elledge S.J. (2007)
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Aliases
TAF1C (Gene Symbol) MGC:39976 SL1 TAFI110 TAFI95 SL1, 110kD subunit TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kD TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa TATA box binding protein-associated factor, RNA polymerase I, C, 110kDa TATA box-binding protein-associated factor 1C TBP-associated factor 1C TBP-associated factor RNA polymerase I 110 kDa transcription factor SL1
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Genome Databases showing TAF1C
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing TAF1C
(According to HUGE )
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Specialized Databases showing TAF1C (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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Name Description
NIEHS-SNPs http://egp.gs.washington.edu/data/taf1c/
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Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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