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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAF1C Gene

protein-coding   GIFtS: 54
GCID: GC16M084211

TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase...

(Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, C,
110kDa1 2
     TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, C,
110kD1
TAFI1102 3 5     MGC:399762
Transcription Initiation Factor SL1/TIF-IB Subunit C2 3     TAFI952
RNA Polymerase I-Specific TBP-Associated Factor 110 KDa2 3     SL1, 110kD Subunit2
TATA Box-Binding Protein-Associated Factor 1C2 3     TATA Box-Binding Protein-Associated Factor RNA Polymerase I Subunit C2
TBP-Associated Factor 1C2 3     Transcription Factor SL12
SL12 5     

External Ids:    HGNC: 115341   Entrez Gene: 90132   Ensembl: ENSG000001031687   OMIM: 6049055   UniProtKB: Q155723   

Export aliases for TAF1C gene to outside databases

Previous GC identifers: GC16M075062 GC16M085178 GC16M083950 GC16M083991 GC16M082768 GC16M069965


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TAF1C Gene:
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding
protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1,
binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for
regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript
variants encoding different isoforms have been identified. (provided by RefSeq, Jul 2011)

GeneCards Summary for TAF1C Gene: 
TAF1C (TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa) is a protein-coding gene. Diseases associated with TAF1C include choroiditis, and hepatitis c, and among its related super-pathways are RNA Polymerase I Promoter Clearance and Assembly of RNA Polymerase-II Initiation Complex. GO annotations related to this gene include DNA binding.

UniProtKB/Swiss-Prot: TAF1C_HUMAN, Q15572
Function: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC
(preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is
primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in
stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association
of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3

Gene Wiki entry for TAF1C Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAF1C gene promoter:
         STAT5B   NF-1/L   NF-1   Pax-5   Olf-1   MyoD   GATA-2   AREB6   COMP1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAF1C promoter sequence
   Search SABiosciences Chromatin IP Primers for TAF1C

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAF1C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24   Ensembl cytogenetic band:  16q24.1   HGNC cytogenetic band: 16q24

TAF1C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAF1C gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M084211:  view genomic region     (about GC identifiers)

Start:
84,211,458 bp from pter      End:
84,220,669 bp from pter
Size:
9,212 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TAF1C_HUMAN, Q15572 (See protein sequence)
Recommended Name: TATA box-binding protein-associated factor RNA polymerase I subunit C  
Size: 869 amino acids; 95213 Da
Subunit: Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B,
TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB
subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with
MYC and RRN3. Interacts with p53/TP53; the interaction prevents the association of SL1/TIF-IB with UBTF and
represses RNA polymerase I transcription
Subcellular location: Nucleus
Sequence caution: Sequence=BAD92831.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Secondary accessions: B7Z5K5 B7Z5S4 B7Z908 B7Z9L7 Q59F67 Q8N6V3
Alternative splicing: 5 isoforms:  Q15572-1   Q15572-2   Q15572-4   Q15572-5   Q15572-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TAF1C: NX_Q15572

Explore proteomics data for TAF1C at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15572

  • TAF1C Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TAF1C Protein Expression
    REFSEQ proteins (7 alternative transcripts): 
    NP_001230085.1  NP_001230086.1  NP_001230087.1  NP_001230088.1  NP_001230089.1  NP_005670.3  NP_647610.2  

    ENSEMBL proteins: 
     ENSP00000345305   ENSP00000455265   ENSP00000456133   ENSP00000455933   ENSP00000455787  
     ENSP00000455247   ENSP00000456101   ENSP00000456011   ENSP00000457281   ENSP00000454854  
     ENSP00000454494   ENSP00000457883   ENSP00000367802   ENSP00000437900  
    Reactome Protein details: Q15572
    Human Recombinant Protein Products for TAF1C: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TAF1C 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--

    TAF1C for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q15572


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAF1C_HUMAN, Q15572
    Function: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC
    (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is
    primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in
    stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association
    of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI17268553
         
    TAF1C for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TAF1C About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Chain Elongation
    RNA Polymerase I Transcription0.92
    RNA Polymerase I Transcription Initiation0.90
    RNA Polymerase I Promoter Clearance0.92
    RNA Polymerase I Transcription Termination0.90
    RNA Polymerase I Promoter Escape0.91
    Assembly of RNA Polymerase-I Initiation Complex0.32
    RNA Polymerase I Chain Elongation0.90
    2Assembly of RNA Polymerase-II Initiation Complex
    Protein Acetylation and Deacetylation0.51
    Crosstalk Between CARM1 and ESRs0.39
    3Transcription
    Transcription0.69
    4RNA Polymerase III Transcription Initiation
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.59
    5Apoptotic Pathways in Synovial Fibroblasts
    Nuclear Receptor Activation by Vitamin-A0.57

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TAF1C (see all 6)
        Nuclear Receptor Activation by Vitamin-A
    Protein Acetylation and Deacetylation
    Assembly of RNA Polymerase-I Initiation Complex
    Glucocorticoid Receptor Signaling
    Estrogen Pathway

    5/9        Reactome Pathways for TAF1C (see all 9)
        RNA Polymerase I Transcription
    RNA Polymerase I Chain Elongation
    Transcription
    RNA Polymerase I Promoter Clearance
    RNA Polymerase I Promoter Escape



    TAF1C for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TAF1C

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/35 Interacting proteins for TAF1C (Q155722, 3 ENSP000003678024) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SETQ011052, 3, ENSP000003617774MINT-4543832 MINT-4544032 MINT-4543954 MINT-4544086 I2D: score=1 STRING: ENSP00000361777
    TBPP202262, 3, ENSP000002303544MINT-4543760 MINT-4544124 MINT-4329018 I2D: score=6 STRING: ENSP00000230354
    SMN1Q166372, 3MINT-8271575 I2D: score=2 
    SMN2Q166372, 3MINT-8271575 I2D: score=2 
    H2AFXP161042, 3MINT-8257966 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006360transcription from RNA polymerase I promoter TAS--
    GO:0006361transcription initiation from RNA polymerase I promoter TAS--
    GO:0006362transcription elongation from RNA polymerase I promoter TAS--
    GO:0006363termination of RNA polymerase I transcription TAS--

    TAF1C for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TAF1C for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TAF1C

    1 Novoseek inferred chemical compound relationship for TAF1C gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    rrna 58.8 4 16033979 (1), 8609157 (1), 17251981 (1)

    Search CenterWatch for drugs/clinical trials and news about TAF1C

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TAF1C gene (7 alternative transcripts): 
    NM_001243156.1  NM_001243157.1  NM_001243158.1  NM_001243159.1  NM_001243160.1  NM_005679.3  NM_139353.2  

    Unigene Cluster for TAF1C:

    TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
    Hs.153022  [show with all ESTs]
    Unigene Representative Sequence: NM_005679
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000341690 ENST00000564774(uc010vnx.2 uc002fho.3 uc010vob.2)
    ENST00000564208(uc010vny.2) ENST00000567759(uc002fhn.3) ENST00000566903
    ENST00000566732 ENST00000544090 ENST00000563428 ENST00000570117 ENST00000568265
    ENST00000562445 ENST00000570270 ENST00000537450 ENST00000562330 ENST00000565279
    ENST00000561955 ENST00000569505 ENST00000564345
    miRNA
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    Additional mRNA sequence: 

    AK097031.1 AK299060.1 AK299347.1 AK304261.1 AK304739.1 AK315982.1 BC028131.1 L39059.1 

    17 DOTS entries:

    DT.91756320  DT.100817177  DT.75136465  DT.95156013  DT.75157385  DT.91756310  DT.120706095  DT.97780383 
    DT.95081649  DT.120706113  DT.75128266  DT.75154881  DT.95214266  DT.100708171  DT.120706057  DT.99945102 
    DT.95179571 

    24/169 AceView cDNA sequences (see all 169):

    CA397964 AI968459 AW590905 CA397963 AI361690 AW161201 BQ928487 CA454870 
    NM_005679 CB305726 BU857614 AA641432 BM717341 BQ186774 AW269860 AI312042 
    AI963810 BQ448038 AW770265 BX350449 NM_139353 BM976286 BQ065265 AI201588 

    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for TAF1C (see all 18)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a ·
    SP1:                                      -     -     -     -     -     -                                                                                   -   
    SP2:                                      -     -                       -                                                                                       
    SP3:                                      -                             -                             -     -     -     -     -     -     -     -     -     -   
    SP4:                                      -                             -                                                                                       
    SP5:                                      -     -                       -                                                                                       

    ExUns: 11b · 11c ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b
    SP1:  -                             -     -                                             
    SP2:                                                                                    
    SP3:  -                                                                                 
    SP4:                                                                                    
    SP5:                                                                                    


    ECgene alternative splicing isoforms for TAF1C

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TAF1C expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTAAGGGAG
    TAF1C Expression
    About this image


    See TAF1C Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TAF1C

    SOURCE GeneReport for Unigene cluster: Hs.153022
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TAF1C gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Taf1c1 , 5 TATA box binding protein (Tbp)-associated factor, RNA more1, 5 74.07(n)1
    66.99(a)1
      8 (68.02 cM)5
    213411  NM_021441.21  NP_067416.21 
     1195979755 
    chicken
    (Gallus gallus)
    Aves TAF1C6
    TATA box binding protein (TBP)-associated factor, ...
    34(a)
    1 ↔ 1
    Z(8946962-8951057)
    lizard
    (Anolis carolinensis)
    Reptilia --
    TAF1C6
    Uncharacterized protein
    30(a)
    26(a)
    many → 1
    many → 1
    GL344232.1(1654-20040)
    AAWZ02037297(3559-12909)
    zebrafish
    (Danio rerio)
    Actinopterygii TAF1C6
    TATA box binding protein (TBP)-associated factor, ...
    22(a)
    1 ↔ 1
    21(5787537-5815705)


    ENSEMBL Gene Tree for TAF1C (if available)
    TreeFam Gene Tree for TAF1C (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/515 SNPs in TAF1C are shown (see all 515)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10566111,2
    C,F,H--84212031(-) ATGCCT/GTGGAT 7 -- ut3131Minor allele frequency- G:0.19EA NS MN NA WA CSA 4452
    rs41501791,2
    C,F--84212088(-) TGCTGT/CTGTGG 7 -- ut311Minor allele frequency- C:0.01NS 180
    rs31971881,2
    C,F,A,H--84212108(-) GCACAG/ACGGCC 7 -- ut31 ese328Minor allele frequency- A:0.24EA NS MN NA CSA WA 4786
    rs1445944321,2
    --84212207(+) GAAGGC/TGTGAG 7 -- ut310--------
    rs1385345821,2
    --84212221(+) TGAGGA/GACCTG 7 -- ut310--------
    rs41501781,2
    C,F--84212250(-) CGCTGC/TGCCTC 7 -- ut31 ese33Minor allele frequency- T:0.01NS NA 176
    rs1159422351,2
    C,F--84212286(+) AAATCC/GCAGCA 7 -- ut311Minor allele frequency- G:0.07WA 118
    rs1890227901,2
    --84212433(+) CAGTGA/GCCTCC 7 -- ut310--------
    rs2009776801,2
    C--84212498(+) CCAGAG/TGAAGG 7 -- ut310--------
    rs1401646521,2
    C--84212529(+) TGAGGG/TCAGCC 7 -- ut310--------

    HapMap Linkage Disequilibrium report for TAF1C (84211458 - 84220669 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for TAF1C:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv518331CNV Loss19592680
    nsv457597CNV Loss19166990
    nsv907063CNV Loss21882294
    nsv907062CNV Loss21882294
    nsv523437CNV Loss19592680
    nsv833309CNV Loss17160897
    nsv907061CNV Loss21882294
    nsv907059CNV Gain21882294


    Human Gene Mutation Database (HGMD): TAF1C
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604905    OMIM disorders: --

    5 diseases for TAF1C:    About MalaCards
    choroiditis    hepatitis c    myeloid leukemia    hepatitis
    leukemia


    TAF1C for disorders           About GeneDecksing

    Genetic Association Database (GAD): TAF1C
    Human Genome Epidemiology (HuGE) Navigator: TAF1C (3 documents)

    Export disorders for TAF1C gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TAF1C gene, integrated from 9 sources (see all 57):
    (articles sorted by number of sources associating them with TAF1C)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits. (PubMed id 7801123)1, 2, 3 Comai L....Tjian R. (1994)
    2. A genome-wide scan for common alleles affecting risk for autism. (PubMed id 20663923)1, 4 Anney R....Hallmayer J. (2010)
    3. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    4. c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I. (PubMed id 15723054)1, 2 Grandori C.... White R.J. (2005)
    5. TBP-TAF complex SL1 directs RNA polymerase I pre-initiation complex formation and stabilizes upstream binding factor at the rDNA promoter. (PubMed id 15970593)1, 2 Friedrich J.K.... Zomerdijk J.C.B.M. (2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. hRRN3 is essential in the SL1-mediated recruitment of RNA polymerase I to rRNA gene promoters. (PubMed id 11250903)1, 2 Miller G.... Zomerdijk J.C.B.M. (2001)
    9. Repression of RNA polymerase I transcription by the tumor suppressor p53. (PubMed id 10913176)1, 2 Zhai W. and Comai L. (2000)
    10. A novel TBP-associated factor of SL1 functions in RNA polymerase I transcription. (PubMed id 17318177)1, 9 Gorski J.J.... Zomerdijk J.C.B.M. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9013 HGNC: 11534 AceView: TAF1C Ensembl:ENSG00000103168 euGenes: HUgn9013
    ECgene: TAF1C H-InvDB: TAF1C

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TAF1C Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/taf1c/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TAF1C gene:
    Search GeneIP for patents involving TAF1C

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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