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Aliases for TAF1C Gene

Aliases for TAF1C Gene

  • TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit C 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, C, 110kDa 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, C, 110kD 2 3
  • TATA-Box Binding Protein Associated Factor, RNA Polymerase I, C 3 5
  • RNA Polymerase I-Specific TBP-Associated Factor 110 KDa 3 4
  • Transcription Initiation Factor SL1/TIF-IB Subunit C 3 4
  • TATA Box-Binding Protein-Associated Factor 1C 3 4
  • TBP-Associated Factor 1C 3 4
  • TAFI110 3 4
  • TATA Box Binding Protein Associated Factor 1C 3
  • Transcription Factor SL1 3
  • SL1, 110kD Subunit 3
  • MGC:39976 3
  • TAFI95 3
  • SL1 3

External Ids for TAF1C Gene

Previous GeneCards Identifiers for TAF1C Gene

  • GC16M075062
  • GC16M085178
  • GC16M083950
  • GC16M083991
  • GC16M082768
  • GC16M084211
  • GC16M069965

Summaries for TAF1C Gene

Entrez Gene Summary for TAF1C Gene

  • Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2011]

GeneCards Summary for TAF1C Gene

TAF1C (TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit C) is a Protein Coding gene. Among its related pathways are Gene Expression and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3.

UniProtKB/Swiss-Prot for TAF1C Gene

  • Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3.

Gene Wiki entry for TAF1C Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF1C Gene

Genomics for TAF1C Gene

Regulatory Elements for TAF1C Gene

Promoters for TAF1C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TAF1C on UCSC Golden Path with GeneCards custom track

Genomic Location for TAF1C Gene

Chromosome:
16
Start:
84,177,847 bp from pter
End:
84,187,070 bp from pter
Size:
9,224 bases
Orientation:
Minus strand

Genomic View for TAF1C Gene

Genes around TAF1C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF1C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF1C Gene

Proteins for TAF1C Gene

  • Protein details for TAF1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15572-TAF1C_HUMAN
    Recommended name:
    TATA box-binding protein-associated factor RNA polymerase I subunit C
    Protein Accession:
    Q15572
    Secondary Accessions:
    • B7Z5K5
    • B7Z5S4
    • B7Z908
    • B7Z9L7
    • Q59F67
    • Q8N6V3

    Protein attributes for TAF1C Gene

    Size:
    869 amino acids
    Molecular mass:
    95213 Da
    Quaternary structure:
    • Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with MYC and RRN3. Interacts with p53/TP53; the interaction prevents the association of SL1/TIF-IB with UBTF and represses RNA polymerase I transcription.
    SequenceCaution:
    • Sequence=BAD92831.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for TAF1C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAF1C Gene

Proteomics data for TAF1C Gene at MOPED

Post-translational modifications for TAF1C Gene

  • Ubiquitination at Lys 124, Lys 258, Lys 323, Lys 409, Lys 434, and Lys 645
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TAF1C Gene

Domains & Families for TAF1C Gene

Protein Domains for TAF1C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAF1C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TAF1C: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TAF1C Gene

Function for TAF1C Gene

Molecular function for TAF1C Gene

UniProtKB/Swiss-Prot Function:
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. Recruits RNA polymerase I to the rRNA gene promoter via interaction with RRN3.
genes like me logo Genes that share phenotypes with TAF1C: view

Animal Model Products

miRNA for TAF1C Gene

miRTarBase miRNAs that target TAF1C

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAF1C Gene

Localization for TAF1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF1C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAF1C Gene COMPARTMENTS Subcellular localization image for TAF1C gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for TAF1C Gene

Pathways & Interactions for TAF1C Gene

genes like me logo Genes that share pathways with TAF1C: view

Gene Ontology (GO) - Biological Process for TAF1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000183 chromatin silencing at rDNA TAS --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006361 transcription initiation from RNA polymerase I promoter TAS --
GO:0006366 transcription from RNA polymerase II promoter TAS 7801123
GO:0040029 regulation of gene expression, epigenetic TAS --
genes like me logo Genes that share ontologies with TAF1C: view

No data available for SIGNOR curated interactions for TAF1C Gene

Drugs & Compounds for TAF1C Gene

(1) Additional Compounds for TAF1C Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TAF1C: view

Transcripts for TAF1C Gene

Unigene Clusters for TAF1C Gene

TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAF1C Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a ·
SP1: - - - - - - -
SP2: - - -
SP3: - - - - - - - - - - - -
SP4: - -
SP5: - - -
SP6:
SP7: - - - -
SP8: -
SP9: - -
SP10: -
SP11: -
SP12: - - - - - - - - - - - -
SP13: - - - - - - - -
SP14:
SP15:
SP16:
SP17:
SP18: -

ExUns: 11b · 11c ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18a · 18b
SP1: - - -
SP2:
SP3: -
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10: -
SP11: -
SP12:
SP13:
SP14: - - - -
SP15:
SP16:
SP17:
SP18:

Relevant External Links for TAF1C Gene

GeneLoc Exon Structure for
TAF1C
ECgene alternative splicing isoforms for
TAF1C

Expression for TAF1C Gene

mRNA expression in normal human tissues for TAF1C Gene

Protein differential expression in normal tissues from HIPED for TAF1C Gene

This gene is overexpressed in Liver (39.7) and Brain (23.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TAF1C Gene



SOURCE GeneReport for Unigene cluster for TAF1C Gene Hs.153022

genes like me logo Genes that share expression patterns with TAF1C: view

Protein tissue co-expression partners for TAF1C Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TAF1C Gene

Orthologs for TAF1C Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAF1C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TAF1C 35
  • 79.79 (n)
  • 72.98 (a)
TAF1C 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAF1C 35
  • 79.34 (n)
  • 75.31 (a)
TAF1C 36
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taf1c 35
  • 73.87 (n)
  • 66.75 (a)
Taf1c 16
Taf1c 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TAF1C 35
  • 99.09 (n)
  • 98.34 (a)
TAF1C 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Taf1c 35
  • 74.83 (n)
  • 69.12 (a)
oppossum
(Monodelphis domestica)
Mammalia TAF1C 36
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAF1C 36
  • 32 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101750393 35
  • 54.33 (n)
  • 41.65 (a)
TAF1C 36
  • 35 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 30 (a)
OneToMany
-- 36
  • 30 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496040 35
  • 45.83 (n)
  • 32.14 (a)
zebrafish
(Danio rerio)
Actinopterygii TAF1C 36
  • 23 (a)
OneToOne
Species with no ortholog for TAF1C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAF1C Gene

ENSEMBL:
Gene Tree for TAF1C (if available)
TreeFam:
Gene Tree for TAF1C (if available)

Paralogs for TAF1C Gene

No data available for Paralogs for TAF1C Gene

Variants for TAF1C Gene

Sequence variations from dbSNP and Humsavar for TAF1C Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs4150145 - 84,181,869(-) TCCCT(C/T)CTCAG intron-variant, reference, missense
rs4150147 - 84,181,628(-) CAGCC(A/G)CTCGG reference, missense, utr-variant-5-prime
rs4150151 - 84,181,410(-) CTCTT(C/T)GTGGC reference, missense, utr-variant-5-prime
rs4150165 - 84,180,179(-) TGCTG(C/T)ACCTG reference, missense
rs4150170 - 84,179,833(-) CGTCC(C/T)GCCCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TAF1C Gene

Variant ID Type Subtype PubMed ID
nsv907059 CNV Gain 21882294
nsv833309 CNV Loss 17160897
nsv907061 CNV Loss 21882294
nsv518331 CNV Loss 19592680
nsv523437 CNV Loss 19592680
nsv907062 CNV Loss 21882294
nsv907063 CNV Loss 21882294
nsv457597 CNV Loss 19166990

Variation tolerance for TAF1C Gene

Residual Variation Intolerance Score: 97.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.14; 84.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAF1C Gene

HapMap Linkage Disequilibrium report
TAF1C
Human Gene Mutation Database (HGMD)
TAF1C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF1C Gene

Disorders for TAF1C Gene

Relevant External Links for TAF1C

Genetic Association Database (GAD)
TAF1C
Human Genome Epidemiology (HuGE) Navigator
TAF1C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAF1C

No disorders were found for TAF1C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAF1C Gene

Publications for TAF1C Gene

  1. Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits. (PMID: 7801123) Comai L. … Tjian R. (Science 1994) 2 3 4 67
  2. A novel TBP-associated factor of SL1 functions in RNA polymerase I transcription. (PMID: 17318177) Gorski J.J. … Zomerdijk J.C.B.M. (EMBO J. 2007) 3 23
  3. PTEN represses RNA Polymerase I transcription by disrupting the SL1 complex. (PMID: 16055704) Zhang C. … Johnson D.L. (Mol. Cell. Biol. 2005) 3 23
  4. Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter. (PMID: 12393749) Yuan X. … Grummt I. (EMBO Rep. 2002) 3 23
  5. Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1. (PMID: 10894955) Di Pietro C. … Purrello M. (Cytogenet. Cell Genet. 2000) 3 23

Products for TAF1C Gene

Sources for TAF1C Gene

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