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TAF1B Gene

protein-coding   GIFtS: 55
GCID: GC02P009983

TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase...

(Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, B,
63kDa1 2
     RAFI632 5
Transcription Initiation Factor SL1/TIF-IB Subunit B2 3     SL12 5
TAFI632 3     TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, B,
63kD1
RNA Polymerase I-Specific TBP-Associated Factor 63 KDa2 3     MGC:93492
TATA Box-Binding Protein-Associated Factor 1B2 3     SL1, 63kD Subunit2
TBP-Associated Factor 1B2 3     TATA Box-Binding Protein-Associated Factor RNA Polymerase I Subunit B2
RAF1B2 5     

External Ids:    HGNC: 115331   Entrez Gene: 90142   Ensembl: ENSG000001157507   OMIM: 6049045   UniProtKB: Q53T943   

Export aliases for TAF1B gene to outside databases

Previous GC identifers: GC02P009767 GC02P010034 GC02P010006 GC02P010007 GC02P009934 GC02P009834


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TAF1B Gene:
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding
protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1,
binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for
regulatory signals. This gene encodes one of the SL1-specific TAFs. (provided by RefSeq, Jul 2008)

GeneCards Summary for TAF1B Gene:
TAF1B (TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa) is a protein-coding gene. GO annotations related to this gene include RNA polymerase I CORE element sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: TAF1B_HUMAN, Q53T94
Function: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key
role in multiple steps during trancription initiation such as preinitiation complex (PIC) assembly and
postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in
Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with
RRN3

Gene Wiki entry for TAF1B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NC_018913.2  NT_005334.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TAF1B gene promoter:
         Nkx3-1 v2   Nkx3-1   Nkx3-1 v4   NRF-2   Zic1   Nkx3-1 v3   Nkx3-1 v1   CUTL1   ZIC2/Zic2   c-Ets-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAF1B promoter sequence
   Search Chromatin IP Primers for TAF1B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAF1B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25   Ensembl cytogenetic band:  2p25.1   HGNC cytogenetic band: 2p25

TAF1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAF1B gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P009983:  view genomic region     (about GC identifiers)

Start:
9,983,483 bp from pter      End:
10,074,545 bp from pter
Size:
91,063 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TAF1B_HUMAN, Q53T94 (See protein sequence)
Recommended Name: TATA box-binding protein-associated factor RNA polymerase I subunit B  
Size: 588 amino acids; 68832 Da
Subunit: Interacts with FLNA (via N-terminus) (By similarity). Component of the transcription factor SL1/TIF-IB
complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP,
TAF1A and TAF1C. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the
transcription factor IID (TFIID) subunits. Interacts with TBP and RRN3
Sequence caution: Sequence=AAA62863.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B4DI42 F8WD72 Q15574 Q8WVC3
Alternative splicing: 3 isoforms:  Q53T94-1   Q53T94-2   Q53T94-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TAF1B: NX_Q53T94

Explore proteomics data for TAF1B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys56, Lys431, Lys508
  • Modification sites at PhosphoSitePlus

  • See TAF1B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005671.2  
    ENSEMBL proteins: 
     ENSP00000263663   ENSP00000414184   ENSP00000402955   ENSP00000475608   ENSP00000379542  
    Reactome Protein details: Q53T94

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR021752 TF_Rrn7

    Graphical View of Domain Structure for InterPro Entry Q53T94

    ProtoNet protein and cluster: Q53T94

    UniProtKB/Swiss-Prot: TAF1B_HUMAN, Q53T94
    Domain: Although it shares weak sequence similarity with GTF2B/TFIIB, displays a similar subdomain organization as
    GTF2B/TFIIB, with a N-terminal zinc finger, a connecting region (composed of B-reader and B-linker regions),
    followed by 2 cyclin folds. The RRN7-type zinc finger plays an essential postrecruitment role in Pol I
    transcription at a step preceding synthesis of the first 40 nucleotides (PubMed:21921198 and PubMed:21921199)
    Similarity: Belongs to the RRN7/TAF1B family
    Similarity: Contains 1 RRN7-type zinc finger


    Find genes that share domains with TAF1B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAF1B_HUMAN, Q53T94
    Function: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key
    role in multiple steps during trancription initiation such as preinitiation complex (PIC) assembly and
    postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in
    Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with
    RRN3

         Genatlas biochemistry entry for TAF1B:
    template activating factor I,specifically interactin with mitotic cyclin B

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001164RNA polymerase I CORE element sequence-specific DNA binding IDA--
    GO:0001187RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity IDA--
    GO:0003700sequence-specific DNA binding transcription factor activity NAS7801123
    GO:0005515protein binding IPI17318177
    GO:0017025TBP-class protein binding TAS--
         
    Find genes that share ontologies with TAF1B           About GenesLikeMe


    Animal Models:
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TAF1B_HUMAN, Q53T94: Nucleus, nucleolus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    endoplasmic reticulum1
    golgi apparatus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS7801123
    GO:0005654nucleoplasm TAS--
    GO:0070860RNA polymerase I core factor complex IDA--

    Find genes that share ontologies with TAF1B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TAF1B About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Escape
    RNA Polymerase I Promoter Escape0.88
    RNA Polymerase I Transcription Initiation0.55
    RNA Polymerase I Transcription Termination0.88
    Assembly of RNA Polymerase-I Initiation Complex0.32
    2RNA Polymerase I Promoter Opening
    RNA Polymerase I Transcription0.78
    RNA Polymerase I Promoter Clearance0.78
    RNA Polymerase I Chain Elongation0.78
    RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription0.73
    3Assembly of RNA Polymerase-II Initiation Complex
    Protein Acetylation and Deacetylation0.51
    Crosstalk Between CARM1 and ESRs0.39
    4Apoptotic Pathways in Synovial Fibroblasts
    Nuclear Receptor Activation by Vitamin-A0.57
    5GPCR Pathway
    Estrogen Pathway0.55


    Find genes that share SuperPaths with TAF1B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TAF1B (see all 6)
        Nuclear Receptor Activation by Vitamin-A
    Protein Acetylation and Deacetylation
    Assembly of RNA Polymerase-I Initiation Complex
    Glucocorticoid Receptor Signaling
    Estrogen Pathway

    Selected Reactome Pathways for TAF1B (see all 6)
        RNA Polymerase I Chain Elongation
    SIRT1 negatively regulates rRNA Expression
    RNA Polymerase I Promoter Escape
    NoRC negatively regulates rRNA expression
    RNA Polymerase I Transcription Termination


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TAF1B
    Interactions:

        GeneGlobe Interaction Network for TAF1B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TAF1B (Q53T941, 2, 3 ENSP000002636634) via UniProtKB, MINT, STRING, and/or I2D (see all 64)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST2H4AP628053, ENSP000003581624I2D: score=2 STRING: ENSP00000358162
    HIST1H4AP628053, ENSP000003529804I2D: score=2 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=2 
    HIST1H4CP628053I2D: score=2 
    HIST1H4DP628053I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001189RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript IDA--
    GO:0006351transcription, DNA-templated NAS7801123
    GO:0006360transcription from RNA polymerase I promoter TAS--
    GO:0006361transcription initiation from RNA polymerase I promoter TAS--
    GO:0006362transcription elongation from RNA polymerase I promoter TAS--

    Find genes that share ontologies with TAF1B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TAF1B



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TAF1B gene: 
    NM_005680.2  

    Unigene Cluster for TAF1B:

    TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa
    Hs.584833  [show with all ESTs]
    Unigene Representative Sequence: BC018137
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263663(uc010exc.2 uc002qzy.4 uc002qzz.3 uc010yja.2 uc010exd.3)
    ENST00000402170 ENST00000404869 ENST00000497182 ENST00000434858 ENST00000416181
    ENST00000469895 ENST00000480197 ENST00000490432 ENST00000492648 ENST00000396242

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    Additional mRNA sequence: 

    AK026521.1 AK295402.1 AK308070.1 AK309751.1 AK315098.1 BC018137.2 L39061.1 

    16 DOTS entries:

    DT.210623  DT.91752588  DT.101975420  DT.91742818  DT.100777167  DT.300603  DT.100667187  DT.120968403 
    DT.120968441  DT.91752591  DT.100777166  DT.91752592  DT.95107044  DT.99947775  DT.100743103  DT.95258536 

    Selected AceView cDNA sequences (see all 158):

    AA746267 CR616493 CR622846 AW954208 BX117196 AA811940 F09444 CR606132 
    AA620887 CA423871 AI436217 BM980859 BQ027174 BX389511 BX108728 AA419519 
    N52858 AA236342 AI039712 BQ721523 AL545813 AK124192 BP353780 R80583 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TAF1B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAAGTGAG
    TAF1B Expression
    About this image

    TAF1B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TAF1B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.584833
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TAF1B gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Taf1b1 , 5 TATA box binding protein (Tbp)-associated factor, RNA more1, 5 80.44(n)1
    75.31(a)1
      12 (8.49 cM)5
    213401  NM_020614.21  NP_065639.21 
     244985815 
    chicken
    (Gallus gallus)
    Aves TAF1B1 TATA box binding protein (TBP)-associated factor, RNA more 64.84(n)
    55.04(a)
      421933  NM_001006416.1  NP_001006416.1 
    lizard
    (Anolis carolinensis)
    Reptilia TAF1B6
    TATA box binding protein (TBP)-associated factor, ...
    44(a)
    1 ↔ 1
    1(148191308-148247259)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC528432 similar to TATA box binding protein (TBP)-associated more 74.32(n)    BC042352.1 
    zebrafish
    (Danio rerio)
    Actinopterygii taf1b1 TATA box binding protein (Tbp)-associated factor, RNA more 50.49(n)
    39.05(a)
      449647  NM_001025298.1  NP_001020469.1 


    ENSEMBL Gene Tree for TAF1B (if available)
    TreeFam Gene Tree for TAF1B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TAF1B (see all 2014)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1134585401,2
    C--9981598(+) CAAAAT/CTTAGC 1 -- us2k11Minor allele frequency- C:0.00NA 2
    rs2011677591,2
    --9981606(+) AGCCA-/GGTGTG 1 -- us2k10--------
    rs1127171311,2
    C--9981672(+) GAACCC/TGGGAA 1 -- us2k12Minor allele frequency- T:0.00NA CSA 3
    rs1911119761,2
    --9981763(+) TGGTGA/GAATTT 1 -- us2k10--------
    rs743888731,2
    C--9981845(+) GATGCC/TCCTAC 1 -- us2k10--------
    rs1811455411,2
    --9981903(+) GCTCCA/GTTGCT 1 -- us2k10--------
    rs1425231111,2
    --9981929(+) TGGCCC/GGATTA 1 -- us2k10--------
    rs727809991,2
    C--9981970(+) CCTCCC/TGTCTC 1 -- us2k15Minor allele frequency- T:0.22NA CSA WA EA 361
    rs1409761491,2
    C--9982107(+) CTCTC-/TTCTTAA 1 -- us2k10--------
    rs1113856251,2
    C--9982169(+) TTTGGA/GAGGCC 1 -- us2k12Minor allele frequency- G:0.00NA CSA 3

    HapMap Linkage Disequilibrium report for TAF1B (9983483 - 10074545 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TAF1B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv873632CNV Loss21882294
    nsv873631CNV Loss21882294
    dgv4047n71CNV Gain21882294
    dgv4048n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for TAF1B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604904    OMIM disorders: --


    Find genes that share disorders with TAF1B           About GenesLikeMe

    Genetic Association Database (GAD): TAF1B
    Human Genome Epidemiology (HuGE) Navigator: TAF1B (2 documents)

    Export disorders for TAF1B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TAF1B gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with TAF1B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits. (PubMed id 7801123)1, 2, 3 Comai L....Tjian R. (Science 1994)
    2. Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1. (PubMed id 10894955)1, 2, 9 Di Pietro C.... Purrello M. (Cytogenet. Cell Genet. 2000)
    3. Yeast Rrn7 and human TAF1B are TFIIB-related RNA polymerase I general transcription factors. (PubMed id 21921198)1, 2 Knutson B.A. and Hahn S. (Science 2011)
    4. TAF1B is a TFIIB-like component of the basal transcription machinery for RNA polymerase I. (PubMed id 21921199)1, 2 Naidu S.... Zomerdijk J.C. (Science 2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. hRRN3 is essential in the SL1-mediated recruitment of RNA polymerase I to rRNA gene promoters. (PubMed id 11250903)1, 2 Miller G.... Zomerdijk J.C.B.M. (EMBO J. 2001)
    9. Identification of MARCKS, FLJ11383 and TAF1B as putative novel target genes in colorectal carcinomas with microsatellite instability. (PubMed id 12140758)1, 9 Kim N.-G....Kim H. (Oncogene 2002)
    10. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9014 HGNC: 11533 AceView: TAF1B Ensembl:ENSG00000115750 euGenes: HUgn9014
    ECgene: TAF1B H-InvDB: TAF1B

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TAF1B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TAF1B gene:
    Search GeneIP for patents involving TAF1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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