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Aliases for TAF1B Gene

Aliases for TAF1B Gene

  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, B, 63kDa 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, B, 63kD 2 3
  • RNA Polymerase I-Specific TBP-Associated Factor 63 KDa 3 4
  • Transcription Initiation Factor SL1/TIF-IB Subunit B 3 4
  • TATA Box-Binding Protein-Associated Factor 1B 3 4
  • TBP-Associated Factor 1B 3 4
  • TAFI63 3 4
  • SL1, 63kD Subunit 3
  • MGC:9349 3
  • RAFI63 3
  • RAF1B 3
  • SL1 3

External Ids for TAF1B Gene

Previous GeneCards Identifiers for TAF1B Gene

  • GC02P009767
  • GC02P010034
  • GC02P010006
  • GC02P010007
  • GC02P009934
  • GC02P009983

Summaries for TAF1B Gene

Entrez Gene Summary for TAF1B Gene

  • Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAF1B Gene

TAF1B (TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, B, 63kDa) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase I CORE element sequence-specific DNA binding.

UniProtKB/Swiss-Prot for TAF1B Gene

  • Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during trancription initiation such as preinitiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.

Gene Wiki entry for TAF1B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF1B Gene

Genomics for TAF1B Gene

Regulatory Elements for TAF1B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TAF1B Gene

Chromosome:
2
Start:
9,843,354 bp from pter
End:
9,934,416 bp from pter
Size:
91,063 bases
Orientation:
Plus strand

Genomic View for TAF1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAF1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF1B Gene

Proteins for TAF1B Gene

  • Protein details for TAF1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53T94-TAF1B_HUMAN
    Recommended name:
    TATA box-binding protein-associated factor RNA polymerase I subunit B
    Protein Accession:
    Q53T94
    Secondary Accessions:
    • B4DI42
    • F8WD72
    • Q15574
    • Q8WVC3

    Protein attributes for TAF1B Gene

    Size:
    588 amino acids
    Molecular mass:
    68832 Da
    Quaternary structure:
    • Interacts with FLNA (via N-terminus) (By similarity). Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1C. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with TBP and RRN3.
    SequenceCaution:
    • Sequence=AAA62863.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TAF1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAF1B Gene

Proteomics data for TAF1B Gene at MOPED

Post-translational modifications for TAF1B Gene

  • Ubiquitination at Lys 56, Lys 431, and Lys 508
  • Modification sites at PhosphoSitePlus

Other Protein References for TAF1B Gene

No data available for DME Specific Peptides for TAF1B Gene

Domains & Families for TAF1B Gene

Protein Domains for TAF1B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TAF1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53T94

UniProtKB/Swiss-Prot:

TAF1B_HUMAN :
  • Although it shares weak sequence similarity with GTF2B/TFIIB, displays a similar subdomain organization as GTF2B/TFIIB, with a N-terminal zinc finger, a connecting region (composed of B-reader and B-linker regions), followed by 2 cyclin folds. The RRN7-type zinc finger plays an essential postrecruitment role in Pol I transcription at a step preceding synthesis of the first 40 nucleotides (PubMed:21921198 and PubMed:21921199)
  • Belongs to the RRN7/TAF1B family.
  • Contains 1 RRN7-type zinc finger.
Domain:
  • Although it shares weak sequence similarity with GTF2B/TFIIB, displays a similar subdomain organization as GTF2B/TFIIB, with a N-terminal zinc finger, a connecting region (composed of B-reader and B-linker regions), followed by 2 cyclin folds. The RRN7-type zinc finger plays an essential postrecruitment role in Pol I transcription at a step preceding synthesis of the first 40 nucleotides (PubMed:21921198 and PubMed:21921199)
Family:
  • Belongs to the RRN7/TAF1B family.
Similarity:
  • Contains 1 RRN7-type zinc finger.
genes like me logo Genes that share domains with TAF1B: view

No data available for Gene Families for TAF1B Gene

Function for TAF1B Gene

Molecular function for TAF1B Gene

GENATLAS Biochemistry:
template activating factor I,specifically interactin with mitotic cyclin B
UniProtKB/Swiss-Prot Function:
Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during trancription initiation such as preinitiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.

Gene Ontology (GO) - Molecular Function for TAF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001164 RNA polymerase I CORE element sequence-specific DNA binding IDA 21921198
GO:0001187 transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting IDA 21921198
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 7801123
GO:0005515 protein binding IPI 17318177
GO:0017025 TBP-class protein binding TAS 21921199
genes like me logo Genes that share ontologies with TAF1B: view

Phenotypes for TAF1B Gene

GenomeRNAi human phenotypes for TAF1B:
genes like me logo Genes that share phenotypes with TAF1B: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAF1B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TAF1B Gene

Localization for TAF1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF1B Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAF1B Gene COMPARTMENTS Subcellular localization image for TAF1B gene
Compartment Confidence
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for TAF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 7801123
GO:0005654 nucleoplasm TAS --
GO:0005668 RNA polymerase transcription factor SL1 complex IBA --
GO:0070062 extracellular exosome IDA 23376485
GO:0070860 RNA polymerase I core factor complex IDA 21921198
genes like me logo Genes that share ontologies with TAF1B: view

Pathways & Interactions for TAF1B Gene

genes like me logo Genes that share pathways with TAF1B: view

Gene Ontology (GO) - Biological Process for TAF1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000183 chromatin silencing at rDNA TAS --
GO:0001189 RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript IDA 21921199
GO:0006351 transcription, DNA-templated NAS 7801123
GO:0006360 transcription from RNA polymerase I promoter TAS --
GO:0006361 transcription initiation from RNA polymerase I promoter TAS --
genes like me logo Genes that share ontologies with TAF1B: view

No data available for SIGNOR curated interactions for TAF1B Gene

Drugs & Compounds for TAF1B Gene

No Compound Related Data Available

Transcripts for TAF1B Gene

Unigene Clusters for TAF1B Gene

TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAF1B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAF1B Gene

No ASD Table

Relevant External Links for TAF1B Gene

GeneLoc Exon Structure for
TAF1B
ECgene alternative splicing isoforms for
TAF1B

Expression for TAF1B Gene

mRNA expression in normal human tissues for TAF1B Gene

Protein differential expression in normal tissues from HIPED for TAF1B Gene

This gene is overexpressed in Lung (51.7) and Platelet (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAF1B Gene



SOURCE GeneReport for Unigene cluster for TAF1B Gene Hs.584833

genes like me logo Genes that share expression patterns with TAF1B: view

Protein tissue co-expression partners for TAF1B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TAF1B Gene

Orthologs for TAF1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAF1B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TAF1B 35
  • 85.66 (n)
  • 81.29 (a)
TAF1B 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAF1B 35
  • 87.17 (n)
  • 83.83 (a)
TAF1B 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taf1b 35
  • 80.44 (n)
  • 75.31 (a)
Taf1b 16
Taf1b 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TAF1B 35
  • 99.21 (n)
  • 99.32 (a)
TAF1B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Taf1b 35
  • 79.39 (n)
  • 74.96 (a)
oppossum
(Monodelphis domestica)
Mammalia TAF1B 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 63 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
chicken
(Gallus gallus)
Aves TAF1B 35
  • 64.84 (n)
  • 55.04 (a)
TAF1B 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAF1B 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia taf1b 35
  • 58.93 (n)
  • 50 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC52843 35
zebrafish
(Danio rerio)
Actinopterygii taf1b 35
  • 50.49 (n)
  • 39.05 (a)
taf1b 36
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToOne
Species with no ortholog for TAF1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAF1B Gene

ENSEMBL:
Gene Tree for TAF1B (if available)
TreeFam:
Gene Tree for TAF1B (if available)

Paralogs for TAF1B Gene

No data available for Paralogs for TAF1B Gene

Variants for TAF1B Gene

Sequence variations from dbSNP and Humsavar for TAF1B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs287972 -- 9,867,602(-) AAGCC(A/G)TGATT intron-variant
rs287973 -- 9,866,398(-) actgg(C/T)gtgag intron-variant
rs287974 -- 9,866,205(-) tctgg(A/G)tatta intron-variant
rs287985 -- 9,844,469(+) CACAC(A/G)CTTTG intron-variant, missense, reference, upstream-variant-2KB
rs287986 -- 9,845,477(+) ATAGG(C/T)TAAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAF1B Gene

Variant ID Type Subtype PubMed ID
dgv4047n71 CNV Gain 21882294
dgv4048n71 CNV Gain 21882294
nsv873631 CNV Loss 21882294
nsv873632 CNV Loss 21882294

Variation tolerance for TAF1B Gene

Residual Variation Intolerance Score: 71.43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.20; 90.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAF1B Gene

HapMap Linkage Disequilibrium report
TAF1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF1B Gene

Disorders for TAF1B Gene

Relevant External Links for TAF1B

Genetic Association Database (GAD)
TAF1B
Human Genome Epidemiology (HuGE) Navigator
TAF1B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAF1B
genes like me logo Genes that share disorders with TAF1B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAF1B Gene

Publications for TAF1B Gene

  1. Dimerisation of HIV-2 genomic RNA is linked to efficient RNA packaging, normal particle maturation and viral infectivity. (PMID: 18078509) L'Hernault A. … Lever A.M. (Retrovirology 2007) 23 67
  2. Identification of MARCKS, FLJ11383 and TAF1B as putative novel target genes in colorectal carcinomas with microsatellite instability. (PMID: 12140758) Kim N.-G. … Kim H. (Oncogene 2002) 23 67
  3. Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1. (PMID: 10894955) Di Pietro C. … Purrello M. (Cytogenet. Cell Genet. 2000) 23 67
  4. In vivo evidence that TATA-binding protein/SL1 colocalizes with UBF and RNA polymerase I when rRNA synthesis is either active or inactive. (PMID: 8609157) Jordan P. … Carmo-Fonseca M. (J. Cell Biol. 1996) 23 67
  5. Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits. (PMID: 7801123) Comai L. … Tjian R. (Science 1994) 2 67

Products for TAF1B Gene

Sources for TAF1B Gene

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