TAF1B Gene
protein-coding GIFtS: 51
GCID: GC02P009983
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TATA box binding protein (TBP)-associated factor, RNA polymerase...(Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase...)
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Aliases
for TAF1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, B,63kDa1 2 | | TATA Box-Binding Protein-Associated Factor 1B2 3 | | TAFI631 2 3 | | TBP-Associated Factor 1B2 3 | | RAF1B1 2 5 | | TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, B, 63kD1 | | RAFI631 2 5 | | MGC:93492 | | SL11 2 5 | | SL1, 63kD Subunit2 | | Transcription Initiation Factor SL1/TIF-IB Subunit B2 3 | | TATA Box-Binding Protein-Associated Factor RNA Polymerase I Subunit B2 | | RNA Polymerase I-Specific TBP-Associated Factor 63 KDa2 3 | | |
Export aliases for TAF1B gene to outside databasesPrevious GC identifers: GC02P009767 GC02P010034 GC02P010006 GC02P010007 GC02P009934 GC02P009834 |
Summaries
for TAF1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TAF1B:
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-bindingprotein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, bindsto the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatorysignals. This gene encodes one of the SL1-specific TAFs. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: TAF1B_HUMAN, Q53T94Function: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key rolein multiple steps during trancription initiation such as preinitiation complex (PIC) assembly and postpolymeraserecruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitmentas a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3
Gene Wiki entry for TAF1B
|
Genomic Views
for TAF1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005334.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TAF1B gene promoter:
Nkx3-1 v2 Nkx3-1 Nkx3-1 v4 NRF-2 Zic1 Nkx3-1 v3 Nkx3-1 v1 CUTL1 ZIC2/Zic2 c-Ets-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TAF1B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAF1B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p25 Ensembl cytogenetic band: 2p25.1 HGNC cytogenetic band: 2p25TAF1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P009983: view genomic region
(about GC identifiers)
Start:
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9,983,483 bp from pter |
End:
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10,074,545 bp from pter |
Size:
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91,063 bases |
Orientation:
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plus strand |
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Proteins
for TAF1B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TAF1B_HUMAN, Q53T94 (See
protein sequence)Recommended Name: TATA box-binding protein-associated factor RNA polymerase I subunit B Size: 588 amino acids; 68832 Da
Subunit: Interacts with FLNA (via N-terminus) (By similarity). Component of the transcription factor SL1/TIF-IBcomplex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1Aand TAF1C. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factorIID (TFIID) subunits. Interacts with TBP and RRN3
Subcellular location: Nucleus, nucleolus
Sequence caution: Sequence=AAA62863.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B4DI42 F8WD72 Q15574 Q8WVC3Alternative splicing: 3 isoforms: Q53T94-1 Q53T94-2 Q53T94-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TAF1B: NX_Q53T94
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q53T94
TAF1B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005671.2
ENSEMBL proteins: ENSP00000263663 ENSP00000385959 ENSP00000384598 ENSP00000414184 ENSP00000402955 ENSP00000379542 Reactome Protein details: Q53T94
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TAF1B for ontologies About GeneDecksing
TAF1B Antibody Products:
Assay Products for TAF1B: |
Protein
Domains /
Families
for TAF1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TAF1B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q53T94ProtoNet protein and cluster: Q53T94 UniProtKB/Swiss-Prot: TAF1B_HUMAN, Q53T94Domain: Although it shares weak sequence similarity with GTF2B/TFIIB, displays a similar subdomain organization asGTF2B/TFIIB, with a N-terminal zinc finger, a connecting region (composed of B-reader and B-linker regions), followedby 2 cyclin folds. The RRN7-type zinc finger plays an essential postrecruitment role in Pol I transcription at a steppreceding synthesis of the first 40 nucleotides (PubMed:21921198 and PubMed:21921199)Similarity: Belongs to the RRN7/TAF1B familySimilarity: Contains 1 RRN7-type zinc finger |
Function
for TAF1B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TAF1B_HUMAN, Q53T94Function: Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key rolein multiple steps during trancription initiation such as preinitiation complex (PIC) assembly and postpolymeraserecruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitmentas a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3 Genatlas biochemistry entry for TAF1B:template activating factor I,specifically interactin with mitotic cyclin B
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAF1B (see all 2)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF1B |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001164 | RNA polymerase I CORE element sequence-specific DNA binding |
IDA | -- | | GO:0001187 | RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity |
IDA | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
NAS | 7801123 | | GO:0005515 | protein binding |
-- | -- | | GO:0017025 | TBP-class protein binding |
TAS | -- |
TAF1B for ontologies About GeneDecksing
|
Pathways & Interactions
for TAF1B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | RNA Polymerase I Chain Elongation | | | 2 | Assembly of RNA Polymerase-II Initiation Complex | | | 3 | Transcription | | | 4 | RNA Polymerase III Transcription Initiation | | | 5 | Apoptotic Pathways in Synovial Fibroblasts | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TAF1B (see all 6)
5/9 
Reactome Pathways for TAF1B (see all 9)
TAF1B for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TAF1B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/64 Interacting proteins for TAF1B (Q53T942, 3 ENSP000002636634) via UniProtKB, MINT, STRING, and/or I2D (see all 64)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001189 | RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript |
IDA | -- | | GO:0006351 | transcription, DNA-dependent |
NAS | 7801123 | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0006360 | transcription from RNA polymerase I promoter |
TAS | -- | | GO:0006361 | transcription initiation from RNA polymerase I promoter |
TAS | -- |
TAF1B for ontologies About GeneDecksing
|
Drugs & Compounds
for TAF1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TAF1B
Search CenterWatch for drugs/clinical trials and news about TAF1B
|
Transcripts
for TAF1B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TAF1B gene: NM_005680.2 Unigene Cluster for TAF1B: TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa Hs.584833 [show with all ESTs]Unigene Representative Sequence: BC01813711 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000263663(uc010exc.2 uc002qzy.4 uc002qzz.3 uc010yja.2 uc010exd.3)
ENST00000402170 ENST00000404869 ENST00000497182 ENST00000434858 ENST00000416181
ENST00000469895 ENST00000480197 ENST00000490432 ENST00000492648 ENST00000396242
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAF1B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAF1B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TAF1B (NM_005680) | | | DNA2.0 Custom Codon Optimized Gene
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Additional cDNA sequence: AK026521.1 AK295402.1 AK308070.1 AK309751.1 AK315098.1 BC018137.2 L39061.1 16 DOTS entries: DT.210623 DT.91752588 DT.101975420 DT.91742818 DT.100777167 DT.300603 DT.100667187 DT.120968403 DT.120968441 DT.91752591 DT.100777166 DT.91752592 DT.95107044 DT.99947775 DT.100743103 DT.95258536 24/158 AceView cDNA sequences (see all 158): AA746267 CA423871 AW954208 BX117196 AA811940 CR622846 AI436217 AA620887 CR616493 CR606132 F09444 BX389511 BX108728 NM_005680 BX107791 AA779082 BM980859 AI188329 BQ003680 BQ027174 AA416775 BX425268 BQ011382 BP353583
GeneLoc Exon Structure
|
Expression
for TAF1B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TAF1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGAAGTGAG
About this image
See TAF1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TAF1B
SOURCE GeneReport for Unigene cluster: Hs.584833
SABiosciences Custom PCR Arrays for TAF1B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAF1B
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF1B |
Orthologs
for TAF1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TAF1B gene from 5/13 species (see all 13) About this table
ENSEMBL Gene Tree for TAF1B (if available)
TreeFam Gene Tree for TAF1B (if available) |
Paralogs
for TAF1B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TAF1B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TAF1B (9983483 - 10074545 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TAF1B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAF1B |
|
Disorders
/ Diseases
for TAF1B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TAF1B for disorders About GeneDecksing
OMIM gene information: 604904
OMIM disorders: --
2  diseases for TAF1B: About MalaCardscolorectal cancer carcinoma
Human Genome Epidemiology (HuGE) Navigator: TAF1B (2 documents)
Export disorders for TAF1B gene to outside databases
|
Publications
for TAF1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TAF1B gene, integrated from 9 sources (see all 41):
(articles sorted by number of sources associating them with TAF1B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits. (PubMed id 7801123)1, 2, 3 Comai L....Tjian R. (1994)
- Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1. (PubMed id 10894955)1, 2, 9 Di Pietro C....Purrello M. (2000)
- Yeast Rrn7 and human TAF1B are TFIIB-related RNA poly merase I general transcription factors. (PubMed id 21921198)1, 2 Knutson B.A. and Hahn S. (2011)
- TAF1B is a TFIIB-like component of the basal transcri ption machinery for RNA polymerase I. (PubMed id 21921199)1, 2 Naidu S....Zomerdijk J.C. (2011)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- hRRN3 is essential in the SL1-mediated recruitment of RNA polymerase I to rRNA gene promoters. (PubMed id 11250903)1, 2 Miller G.... Zomerdijk J.C.B.M. (2001)
- Identification of MARCKS, FLJ11383 and TAF1B as putative novel target genes in colorectal carcinomas with microsatellite instability. (PubMed id 12140758)1, 9 Kim N.-G....Kim H. (2002)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
|
External Searches for TAF1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TAF1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TAF1B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TAF1B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TAF1B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TAF1B gene:
Search GeneIP for patents involving TAF1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TAF1B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF1B |
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