TAF1A Gene
protein-coding GIFtS : 56
GC01M220797
TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa (Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kD )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases & Descriptions for TAF1A
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases MGC:17061 2 OTTHUMP00000035653 2 OTTHUMP00000035654 2 RAFI48 2 , 5 SL1 1 , 2 , 5 TAFI48 1 , 2 , 3
Descriptions SL1, 48kD subunit 2 TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kD 1 TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa 2 TATA box binding protein-associated factor, RNA polymerase I, A, 48kDa 1 TATA box-binding protein-associated factor 1A 3 TBP-associated factor 1A 2 , 3 TBP-associated factor RNA polymerase I 48 kDa 3 Transcription factor SL1 3
Search outside databases for aliases for TAF1A genePrevious GC identifers: GC01M221325 GC01M218646 GC01M219263 GC01M219787 GC01M219119
Summaries for TAF1A (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for TAF1A : Initiation of transcription by RNA polymerase I requires the formation of a complex composed of theTATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I.This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position thepolymerase properly and acts as a channel for regulatory signals. This gene encodes the smallestSL1-specific TAF. Two transcripts encoding different isoforms have been identified. [provided byRefSeq] UniProtKB/Swiss-Prot: TAF1A_HUMAN, Q15573 Function : Component of the transcription factor SL1/TIFIB complex involved in the assembly of thePIC (preinitiation complex)
Gene Wiki entry for TAF1A
Genomic Location for TAF1A
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1q42 Ensembl cytogenetic band: 1q41 HGNC cytogenetic band: 1q42 TAF1A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M220797:
(about GC identifiers )
Start:
220,786,452 bp from pter
End:
220,829,878 bp from pter
Size:
43,427 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000001.9 NT_021877.18 Proteins for TAF1A
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: TAF1A_HUMAN, Q15573 (See
protein sequence )Recommended Name: TATA box-binding protein-associated factor RNA polymerase I subunit A Size : 450 amino acids; 52676 Da
Subunit : Component of the transcription factor SL1/TIFIB complex which is composed of TBP and atleast TAF1A, TAF1B and TAF1C. In the complex, interacts directly with TBP, TAF1B and TAF1C.Interaction of the SL1/TIFIB subunits with TBP excludes interaction with the transcription factorIID (TFIID) subunits. This mutually exclusive binding directs the formation of promoter and RNApolymerase-selective TBP-TAF complexes
Subcellular location : Nucleus
Secondary accessions : Q9NWA1Alternative splicing : 2 isoforms : Q15573-1 Q15573-2
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_005672.1 NP_647603.1 ENSEMBL proteins: ENSP00000375755 ENSP00000327072 ENSP00000339976 ENSP00000375754 ENSP00000355856 Human Recombinant Proteins                OriGene Purified Recombinant Human Proteins (see all 2 ): TAF1A 3 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for TAF1A: Assays for TAF1A:
Protein
Domains/ Families for TAF1A(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q15573 ProtoNet protein and cluster: Q15573
Gene Function for TAF1A
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_005681 Applied Biosystems Silencer ® siRNAs for TAF1A Sigma-Aldrich siRNA for TAF1A Sigma-Aldrich shRNA for TAF1A Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_005681                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_005681                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_005681  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005681 UniProtKB/Swiss-Prot: TAF1A_HUMAN, Q15573 Function : Component of the transcription factor SL1/TIFIB complex involved in the assembly of thePIC (preinitiation complex)
4 Gene Ontology (GO) molecular function terms (links to tree view) :
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Pathways & Interactions for TAF1A
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for TAF1A 5/28 Interacting proteins for TAF1A (Q15573 2 ENSP00000327072 3 ) via UniProtKB, MINT, and/or STRING (see all 28
)About this table 4 Gene Ontology (GO) biological process terms (links to tree view) :
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Drugs & Compounds for TAF1A (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for TAF1A 1 Novoseek chemical compound relationship for TAF1A gene
Compound
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
s-napc
93.33
1
8339931 (1)
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Transcripts for TAF1A(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_005681 Sigma-Aldrich siRNA for TAF1A Sigma-Aldrich shRNA for TAF1A Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_005681 NM_139352
REFSEQ mRNAs for TAF1A gene (2 alternative transcripts): NM_005681.2 NM_139352.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005681 NM_139352
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_005681                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_005681                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_005681  
Additional cDNA sequence: AK290970.1 AK299536.1 AK307882.1 AK315740.1 BC013808.1 CR612936.1 L39060.1
7 DOTS entries : DT.209757 DT.100021120 DT.40118127 DT.100752251 DT.100739188 DT.91738658 DT.91738665
24/36 AceView cDNA sequences (see all 36
):BQ051078 BM841948 L39060 N66196 AU118970 BU179101 BM845364 BU192019 BX118609 BU839228 BX373108 N39785 AA743681 BQ574624 BC013808 AL527402 BG505180 BI089656 BX505527 AI292312 BE895004 AU145413 BI831878 AA305702
highest scoring ESTs for TAF1A :L39060 AL527402 AL711246 BC013808 BE895004 BI089656 BI755870 BU179101 BX505527 CD639754
Unigene Cluster for TAF1A: TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa Hs.153088 [show with all ESTs ] Unigene Representative Sequence: AK290970 GeneLoc Exon Structure 5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TAF1A (see all 7
) ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 SP1 :               -                 -               SP2 :             -   -                 -           -     SP3 :               -   -                             SP4 :               -   -   -                           SP5 :                                            
About this scheme ECgene alternative splicing isoforms for TAF1A 5 Ensembl transcripts including schematic representations : ENST00000391883
ENST00000352967
ENST00000350027
ENST00000391882
ENST00000366890
Expression for TAF1A
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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TAF1A expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for TAF1A 1 / 2 / 3
3 probe-sets matching TAF1A gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GTGAAAATACSOURCE GeneReport for Unigene cluster: Hs.153088 Expression variation in blood from EXPOLDB for TAF1A
Orthologs for TAF1A
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for TAF1A gene from 5/7 species (see all 7
)
About this table Species with no ortholog for TAF1A ENSEMBL Gene Tree for TAF1A Paralogs for TAF1A (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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SNPs/Variants for TAF1A (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for TAF1A (up to first 250kb)
Disorders & Mutations for TAF1A
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 604903
Medical News for TAF1A (Possibly Related Articles in
Doctor's Guide )
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Publications for TAF1A (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/23 PubMed articles for TAF1A gene (see all 23
): Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits. (PubMed id 7801123) 1, 2, 3, 4 Comai L....Tjian R. (1994) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 3, 4 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1. (PubMed id 10894955) 1, 3 Di Pietro C....Purrello M. (2000) TBP-associated factors interact with DNA and govern species specificity of RNA polymerase I transcription. (PubMed id 8013460) 1, 3 Rudloff U....Grummt I. (1994) The hepatitis delta virus RNA genome interacts with the human RNA polymerases I and III. (PubMed id 19246067) 3 Greco-Stewart V.S....Pelchat M. (2009) c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I. (PubMed id 15723054) 3 Grandori C.... White R.J. (2005) Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription. (PubMed id 15226435) 3 Yamamoto K....Muramatsu M. (2004) The carboxyl-terminus directs TAF(I)48 to the nucleus and nucleolus and associates with multiple nuclear import receptors. (PubMed id 15113842) 3 Dynes J.L....Hori R.T. (2004)
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Aliases
TAF1A (Gene Symbol) MGC:17061 OTTHUMP00000035653 OTTHUMP00000035654 RAFI48 SL1 TAFI48 SL1, 48kD subunit TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kD TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa TATA box binding protein-associated factor, RNA polymerase I, A, 48kDa TATA box-binding protein-associated factor 1A TBP-associated factor 1A TBP-associated factor RNA polymerase I 48 kDa Transcription factor SL1
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Genome Databases showing TAF1A
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing TAF1A
(According to HUGE )
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Specialized Databases showing TAF1A (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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