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Aliases for TAF1A Gene

Aliases for TAF1A Gene

  • TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit A 2 3 5
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, A, 48kDa 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, A, 48kD 2 3
  • RNA Polymerase I-Specific TBP-Associated Factor 48 KDa 3 4
  • Transcription Initiation Factor SL1/TIF-IB Subunit A 3 4
  • TATA Box-Binding Protein-Associated Factor 1A 3 4
  • Transcription Factor SL1 3 4
  • TBP-Associated Factor 1A 3 4
  • TAFI48 3 4
  • TATA Box-Binding Protein-Associated Factor RNA Polymerase I Subunit A 3
  • TATA-Box Binding Protein Associated Factor, RNA Polymerase I, A 3
  • SL1, 48kD Subunit 3
  • MGC:17061 3
  • RAFI48 3
  • SL1 3

External Ids for TAF1A Gene

Previous GeneCards Identifiers for TAF1A Gene

  • GC01M221325
  • GC01M218646
  • GC01M219263
  • GC01M219787
  • GC01M219119
  • GC01M220797
  • GC01M222731
  • GC01M193405

Summaries for TAF1A Gene

Entrez Gene Summary for TAF1A Gene

  • This gene encodes a subunit of the RNA polymerase I complex, Selectivity Factor I (SLI). The encoded protein is a TATA box-binding protein-associated factor that plays a role in the assembly of the RNA polymerase I preinitiation complex. Alternate splicing results in multiple transcript variants encoding multiple isoforms.[provided by RefSeq, Jan 2011]

GeneCards Summary for TAF1A Gene

TAF1A (TATA-Box Binding Protein Associated Factor, RNA Polymerase I Subunit A) is a Protein Coding gene. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Apoptotic Pathways in Synovial Fibroblasts.

UniProtKB/Swiss-Prot for TAF1A Gene

  • Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.

Gene Wiki entry for TAF1A Gene

Additional gene information for TAF1A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF1A Gene

Genomics for TAF1A Gene

Regulatory Elements for TAF1A Gene

Enhancers for TAF1A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H222464 1.8 FANTOM5 Ensembl ENCODE 24.8 +124.5 124529 1 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CICP13 TAF1A ENSG00000272750 HHIPL2 MIA3 TRT-TGT2-1
GH01H221739 1.8 FANTOM5 ENCODE dbSUPER 18.5 +848.1 848110 5 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CICP13 DUSP10 ENSG00000272750 TAF1A LOC105372945
GH01H222710 1.4 ENCODE dbSUPER 23.6 -122.4 -122397 3 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ENSG00000272750 CICP13 BROX TAF1A CAPN2 DISP1 MIA3 FAM177B GC01M222708
GH01H223142 1.1 ENCODE 28.7 -553.3 -553259 2 HDGF PKNOX1 ARNT SIN3A ZNF2 ZNF416 ZNF143 ZNF548 SP3 JUNB CICP5 CICP13 TAF1A ENSG00000272750 LOC100287497 FBXO28 ENSG00000236846 TLR5
GH01H221714 1.9 FANTOM5 Ensembl ENCODE dbSUPER 15.1 +872.6 872610 6 HDGF PKNOX1 FOXA2 ARNT ARID4B FEZF1 ZNF2 YY1 ZNF766 REST CICP13 ENSG00000272750 TAF1A MIA3 HHIPL2 MARC1 DUSP10 LOC105372945
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAF1A on UCSC Golden Path with GeneCards custom track

Promoters for TAF1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000020652 296 1601 FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF548

Genomic Location for TAF1A Gene

Chromosome:
1
Start:
222,557,902 bp from pter
End:
222,590,096 bp from pter
Size:
32,195 bases
Orientation:
Minus strand

Genomic View for TAF1A Gene

Genes around TAF1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF1A Gene

Proteins for TAF1A Gene

  • Protein details for TAF1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15573-TAF1A_HUMAN
    Recommended name:
    TATA box-binding protein-associated factor RNA polymerase I subunit A
    Protein Accession:
    Q15573
    Secondary Accessions:
    • B2RDZ8
    • D3DTB7
    • Q9NWA1

    Protein attributes for TAF1A Gene

    Size:
    450 amino acids
    Molecular mass:
    52676 Da
    Quaternary structure:
    • Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with UBFT. Interacts with CEBPA (isoform 1 and isoform 4) (PubMed:20075868).

    Alternative splice isoforms for TAF1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAF1A Gene

Post-translational modifications for TAF1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TAF1A Gene

Domains & Families for TAF1A Gene

Gene Families for TAF1A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TAF1A Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TAF1A: view

No data available for UniProtKB/Swiss-Prot for TAF1A Gene

Function for TAF1A Gene

Molecular function for TAF1A Gene

UniProtKB/Swiss-Prot Function:
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.

Gene Ontology (GO) - Molecular Function for TAF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 17318177
genes like me logo Genes that share ontologies with TAF1A: view
genes like me logo Genes that share phenotypes with TAF1A: view

Animal Model Products

CRISPR Products

miRNA for TAF1A Gene

miRTarBase miRNAs that target TAF1A

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TAF1A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAF1A Gene

Localization for TAF1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF1A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAF1A gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Microtubules (4)
  • Nucleus (4)
  • Vesicles (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TAF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000120 RNA polymerase I transcription factor complex IEA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0015630 microtubule cytoskeleton IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with TAF1A: view

Pathways & Interactions for TAF1A Gene

genes like me logo Genes that share pathways with TAF1A: view

Gene Ontology (GO) - Biological Process for TAF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006360 transcription from RNA polymerase I promoter TAS 7801123
GO:0006361 transcription initiation from RNA polymerase I promoter TAS --
GO:0006362 transcription elongation from RNA polymerase I promoter TAS --
genes like me logo Genes that share ontologies with TAF1A: view

No data available for SIGNOR curated interactions for TAF1A Gene

Drugs & Compounds for TAF1A Gene

(1) Additional Compounds for TAF1A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TAF1A: view

Transcripts for TAF1A Gene

Unigene Clusters for TAF1A Gene

TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TAF1A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TAF1A Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5:
SP6:
SP7:

Relevant External Links for TAF1A Gene

GeneLoc Exon Structure for
TAF1A
ECgene alternative splicing isoforms for
TAF1A

Expression for TAF1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAF1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TAF1A Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TAF1A Gene



Protein tissue co-expression partners for TAF1A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TAF1A Gene:

TAF1A

SOURCE GeneReport for Unigene cluster for TAF1A Gene:

Hs.153088

Evidence on tissue expression from TISSUES for TAF1A Gene

  • Skin(4.2)
  • Kidney(4.1)
genes like me logo Genes that share expression patterns with TAF1A: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAF1A Gene

Orthologs for TAF1A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAF1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF1A 33 34
  • 99.48 (n)
dog
(Canis familiaris)
Mammalia TAF1A 33 34
  • 87.33 (n)
cow
(Bos Taurus)
Mammalia TAF1A 33 34
  • 85.78 (n)
mouse
(Mus musculus)
Mammalia Taf1a 33 16 34
  • 81.03 (n)
rat
(Rattus norvegicus)
Mammalia Taf1a 33
  • 80.8 (n)
oppossum
(Monodelphis domestica)
Mammalia TAF1A 34
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAF1A 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAF1A 33 34
  • 59.81 (n)
lizard
(Anolis carolinensis)
Reptilia TAF1A 34
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia taf1a 33
  • 55.05 (n)
zebrafish
(Danio rerio)
Actinopterygii taf1a 33 34
  • 50.79 (n)
Species where no ortholog for TAF1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAF1A Gene

ENSEMBL:
Gene Tree for TAF1A (if available)
TreeFam:
Gene Tree for TAF1A (if available)

Paralogs for TAF1A Gene

No data available for Paralogs for TAF1A Gene

Variants for TAF1A Gene

Sequence variations from dbSNP and Humsavar for TAF1A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000049603 -- 222,577,081(+) CCCCA(C/T)CCTTT intron-variant
rs1000154705 -- 222,565,190(+) GCTTG(C/T)TTTTG intron-variant
rs1000271475 -- 222,570,316(+) ATTTA(C/G)AACTA intron-variant
rs1000276793 -- 222,558,770(+) TCTAC(A/G)ACCTA nc-transcript-variant, reference, missense
rs1000307880 -- 222,558,379(+) ATAAC(G/T)GCTGT intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TAF1A Gene

Variant ID Type Subtype PubMed ID
esv2762168 CNV loss 21179565

Variation tolerance for TAF1A Gene

Residual Variation Intolerance Score: 82.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.91; 59.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAF1A Gene

Human Gene Mutation Database (HGMD)
TAF1A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAF1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF1A Gene

Disorders for TAF1A Gene

Relevant External Links for TAF1A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAF1A

No disorders were found for TAF1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAF1A Gene

Publications for TAF1A Gene

  1. Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits. (PMID: 7801123) Comai L … Tjian R (Science (New York, N.Y.) 1994) 2 3 4 22 60
  2. Nucleolar retention of a translational C/EBPalpha isoform stimulates rDNA transcription and cell size. (PMID: 20075868) Müller C … Calkhoven CF (The EMBO journal 2010) 3 4 60
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for TAF1A Gene

Sources for TAF1A Gene

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