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Aliases for TAF1A Gene

Aliases for TAF1A Gene

  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, A, 48kDa 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, A, 48kD 2 3
  • RNA Polymerase I-Specific TBP-Associated Factor 48 KDa 3 4
  • Transcription Initiation Factor SL1/TIF-IB Subunit A 3 4
  • TATA Box-Binding Protein-Associated Factor 1A 3 4
  • Transcription Factor SL1 3 4
  • TBP-Associated Factor 1A 3 4
  • RAFI48 3 6
  • TAFI48 3 4
  • SL1 3 6
  • TATA Box-Binding Protein-Associated Factor RNA Polymerase I Subunit A 3
  • SL1, 48kD Subunit 3
  • MGC:17061 3

External Ids for TAF1A Gene

Previous GeneCards Identifiers for TAF1A Gene

  • GC01M221325
  • GC01M218646
  • GC01M219263
  • GC01M219787
  • GC01M219119
  • GC01M220797
  • GC01M222731
  • GC01M193405

Summaries for TAF1A Gene

Entrez Gene Summary for TAF1A Gene

  • This gene encodes a subunit of the RNA polymerase I complex, Selectivity Factor I (SLI). The encoded protein is a TATA box-binding protein-associated factor that plays a role in the assembly of the RNA polymerase I preinitiation complex. Alternate splicing results in multiple transcript variants encoding multiple isoforms.[provided by RefSeq, Jan 2011]

GeneCards Summary for TAF1A Gene

TAF1A (TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, A, 48kDa) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Apoptotic Pathways in Synovial Fibroblasts.

UniProtKB/Swiss-Prot for TAF1A Gene

  • Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.

Gene Wiki entry for TAF1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF1A Gene

Genomics for TAF1A Gene

Genomic Location for TAF1A Gene

Start:
222,557,902 bp from pter
End:
222,590,096 bp from pter
Size:
32,195 bases
Orientation:
Minus strand

Genomic View for TAF1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAF1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF1A Gene

No data available for Regulatory Elements for TAF1A Gene

Proteins for TAF1A Gene

  • Protein details for TAF1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15573-TAF1A_HUMAN
    Recommended name:
    TATA box-binding protein-associated factor RNA polymerase I subunit A
    Protein Accession:
    Q15573
    Secondary Accessions:
    • B2RDZ8
    • D3DTB7
    • Q9NWA1

    Protein attributes for TAF1A Gene

    Size:
    450 amino acids
    Molecular mass:
    52676 Da
    Quaternary structure:
    • Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1B. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with UBFT. Interacts with CEBPA (isoform 1 and isoform 4) (PubMed:20075868).

    Alternative splice isoforms for TAF1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAF1A Gene

Proteomics data for TAF1A Gene at MOPED

Post-translational modifications for TAF1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAF1A Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TAF1A Gene

Domains for TAF1A Gene

Protein Domains for TAF1A Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TAF1A: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TAF1A Gene

Function for TAF1A Gene

Molecular function for TAF1A Gene

UniProtKB/Swiss-Prot Function:
Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.

Gene Ontology (GO) - Molecular Function for TAF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 17318177
genes like me logo Genes that share ontologies with TAF1A: view

miRNA for TAF1A Gene

miRTarBase miRNAs that target TAF1A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAF1A

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TAF1A Gene

Localization for TAF1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF1A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAF1A Gene COMPARTMENTS Subcellular localization image for TAF1A gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TAF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000120 RNA polymerase I transcription factor complex IEA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0015630 microtubule cytoskeleton IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with TAF1A: view

Pathways for TAF1A Gene

genes like me logo Genes that share pathways with TAF1A: view

Gene Ontology (GO) - Biological Process for TAF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000183 chromatin silencing at rDNA TAS --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006360 transcription from RNA polymerase I promoter TAS --
GO:0006361 transcription initiation from RNA polymerase I promoter TAS --
GO:0006362 transcription elongation from RNA polymerase I promoter TAS --
genes like me logo Genes that share ontologies with TAF1A: view

Compounds for TAF1A Gene

(1) Novoseek inferred chemical compound relationships for TAF1A Gene

Compound -log(P) Hits PubMed IDs
s-napc 93.1 1
genes like me logo Genes that share compounds with TAF1A: view

Transcripts for TAF1A Gene

Unigene Clusters for TAF1A Gene

TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAF1A

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAF1A Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
SP1: - -
SP2: - - - -
SP3: - -
SP4: - - -
SP5:
SP6:
SP7:

Relevant External Links for TAF1A Gene

GeneLoc Exon Structure for
TAF1A
ECgene alternative splicing isoforms for
TAF1A

Expression for TAF1A Gene

mRNA expression in normal human tissues for TAF1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for TAF1A Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAF1A Gene

SOURCE GeneReport for Unigene cluster for TAF1A Gene Hs.153088

genes like me logo Genes that share expressions with TAF1A: view

Expression partners for TAF1A Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TAF1A Gene

Orthologs for TAF1A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAF1A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TAF1A 35
  • 85.78 (n)
  • 79.56 (a)
TAF1A 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAF1A 35
  • 87.33 (n)
  • 82.67 (a)
TAF1A 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taf1a 35
  • 81.03 (n)
  • 79.91 (a)
Taf1a 16
Taf1a 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TAF1A 35
  • 99.48 (n)
  • 99.33 (a)
TAF1A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Taf1a 35
  • 80.8 (n)
  • 77.9 (a)
oppossum
(Monodelphis domestica)
Mammalia TAF1A 36
  • 64 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAF1A 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAF1A 35
  • 59.81 (n)
  • 49.28 (a)
TAF1A 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAF1A 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia taf1a 35
  • 55.05 (n)
  • 44.19 (a)
zebrafish
(Danio rerio)
Actinopterygii taf1a 35
  • 50.79 (n)
  • 42.63 (a)
taf1a 36
  • 36 (a)
OneToOne
Species with no ortholog for TAF1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAF1A Gene

ENSEMBL:
Gene Tree for TAF1A (if available)
TreeFam:
Gene Tree for TAF1A (if available)

Paralogs for TAF1A Gene

No data available for Paralogs for TAF1A Gene

Variants for TAF1A Gene

Sequence variations from dbSNP and Humsavar for TAF1A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1134898 -- 222,561,461(-) CCAGG(C/G)TTTCA reference, synonymous-codon
rs1319392 -- 222,567,271(+) attag(A/C)acaga intron-variant
rs1603741 -- 222,571,096(+) ATCTA(C/T)TGATC intron-variant
rs1603742 -- 222,571,339(+) tgtct(C/G/T)ttctc intron-variant
rs1874809 -- 222,569,720(+) CTATA(C/T)GAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAF1A Gene

Variant ID Type Subtype PubMed ID
nsv873203 CNV Gain 21882294
nsv873205 CNV Loss 21882294

Relevant External Links for TAF1A Gene

HapMap Linkage Disequilibrium report
TAF1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF1A Gene

Disorders for TAF1A Gene

No disorders were found for TAF1A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TAF1A Gene

Publications for TAF1A Gene

  1. Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits. (PMID: 7801123) Comai L. … Tjian R. (Science 1994) 2 3 4 23
  2. TBP-associated factors interact with DNA and govern species specificity of RNA polymerase I transcription. (PMID: 8013460) Rudloff U. … Grummt I. (EMBO J. 1994) 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1. (PMID: 10894955) Di Pietro C. … Purrello M. (Cytogenet. Cell Genet. 2000) 3 23
  5. Identification of a domain within human TAF(I)48, a subunit of Selectivity Factor 1, that interacts with helix 2 of TBP. (PMID: 15315821) Xu S. … Hori R.T. (Gene 2004) 3 23

Products for TAF1A Gene

Sources for TAF1A Gene

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