Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TAF15 Gene

Aliases for TAF15 Gene

  • TAF15 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 68kDa 2 3
  • TAF2N 3 4 6
  • RBP56 3 4 6
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, N, 68kD (RNA-Binding Protein 56) 2 3
  • TAFII68 3 4
  • TATA Box-Binding Protein-Associated Factor 2N (RNA-Binding Protein 56) 3
  • 68 KDa TATA-Binding Protein-Associated Factor 4
  • TATA-Binding Protein-Associated Factor 2N 3
  • TBP-Associated Factor 15 3
  • RNA-Binding Protein 56 4
  • RBP56/CSMF Fusion 3
  • TAF(II)68 4
  • Npl3 3

External Ids for TAF15 Gene

Previous HGNC Symbols for TAF15 Gene

  • TAF2N

Previous GeneCards Identifiers for TAF15 Gene

  • GC17P033906
  • GC17P036172
  • GC17P033985
  • GC17P034282
  • GC17P031160
  • GC17P034136
  • GC17P030321

Summaries for TAF15 Gene

Entrez Gene Summary for TAF15 Gene

  • This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for TAF15 Gene

TAF15 (TAF15 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 68kDa) is a Protein Coding gene. Diseases associated with TAF15 include chondrosarcoma, extraskeletal myxoid and myxoid chondrosarcoma. Among its related pathways are GPCR Pathway and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include RNA binding and nucleotide binding.

UniProtKB/Swiss-Prot for TAF15 Gene

  • RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II).

Gene Wiki entry for TAF15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF15 Gene

Genomics for TAF15 Gene

Regulatory Elements for TAF15 Gene

Genomic Location for TAF15 Gene

Start:
35,713,791 bp from pter
End:
35,864,615 bp from pter
Size:
150,825 bases
Orientation:
Plus strand

Genomic View for TAF15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAF15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF15 Gene

Proteins for TAF15 Gene

  • Protein details for TAF15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92804-RBP56_HUMAN
    Recommended name:
    TATA-binding protein-associated factor 2N
    Protein Accession:
    Q92804
    Secondary Accessions:
    • B2R837
    • Q86X94
    • Q92751

    Protein attributes for TAF15 Gene

    Size:
    592 amino acids
    Molecular mass:
    61830 Da
    Quaternary structure:
    • Belongs to the RNA polymerase II (Pol II) transcriptional multiprotein complex, together with the TATA-binding protein (TBP) and other TBP-associated factors (TAF(II)s). Binds SF1

    Alternative splice isoforms for TAF15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAF15 Gene

Proteomics data for TAF15 Gene at MOPED

Post-translational modifications for TAF15 Gene

  • ADP-ribosylated during genotoxic stress
  • Dimethylated by PRMT1 at Arg-206 to asymmetric dimethylarginine. The methylation may favor nuclear localization and positive regulation of TAF15 transcriptional activity.
  • Ubiquitination at Lys306
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TAF15 Gene

Domains for TAF15 Gene

Gene Families for TAF15 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Graphical View of Domain Structure for InterPro Entry

Q92804

UniProtKB/Swiss-Prot:

RBP56_HUMAN :
  • Q92804
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the RRM TET family.
Similarity:
  • Contains 1 RanBP2-type zinc finger.
genes like me logo Genes that share domains with TAF15: view

Function for TAF15 Gene

Molecular function for TAF15 Gene

UniProtKB/Swiss-Prot Function: RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II).

Gene Ontology (GO) - Molecular Function for TAF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 19124016
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TAF15: view
genes like me logo Genes that share phenotypes with TAF15: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TAF15 Gene

Localization for TAF15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF15 Gene

Nucleus. Cytoplasm. Note=Shuttles from the nucleus to the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAF15 Gene COMPARTMENTS Subcellular localization image for TAF15 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TAF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19124016
GO:0005654 nucleoplasm IDA --
GO:0005730 NOT nucleolus IDA 19124016
GO:0005737 cytoplasm IDA 19124016
genes like me logo Genes that share ontologies with TAF15: view

Pathways for TAF15 Gene

genes like me logo Genes that share pathways with TAF15: view

Interacting Proteins for TAF15 Gene

Gene Ontology (GO) - Biological Process for TAF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045893 positive regulation of transcription, DNA-templated TAS 19124016
genes like me logo Genes that share ontologies with TAF15: view

Transcripts for TAF15 Gene

Unigene Clusters for TAF15 Gene

TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAF15 Gene

No ASD Table

Relevant External Links for TAF15 Gene

GeneLoc Exon Structure for
TAF15
ECgene alternative splicing isoforms for
TAF15

Expression for TAF15 Gene

mRNA expression in normal human tissues for TAF15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TAF15 Gene

SOURCE GeneReport for Unigene cluster for TAF15 Gene Hs.402752

mRNA Expression by UniProt/SwissProt for TAF15 Gene

Q92804-RBP56_HUMAN
Tissue specificity: Ubiquitous. Observed in all fetal and adult tissues
genes like me logo Genes that share expressions with TAF15: view

No data available for mRNA differential expression in normal tissues for TAF15 Gene

Orthologs for TAF15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAF15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF15 35
  • 99.77 (n)
  • 99.66 (a)
mouse
(Mus musculus)
Mammalia Taf15 35
  • 93.28 (n)
  • 95.15 (a)
Taf15 16
chicken
(Gallus gallus)
Aves TAF15 35
  • 78.44 (n)
  • 78.96 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.22119 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5964 35
taf15 35
  • 67.54 (n)
  • 66.84 (a)
zebrafish
(Danio rerio)
Actinopterygii wufa11g05 35
Species with no ortholog for TAF15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAF15 Gene

ENSEMBL:
Gene Tree for TAF15 (if available)
TreeFam:
Gene Tree for TAF15 (if available)

Paralogs for TAF15 Gene

Selected SIMAP similar genes for TAF15 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TAF15: view

No data available for Paralogs for TAF15 Gene

Variants for TAF15 Gene

Sequence variations from dbSNP and Humsavar for TAF15 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs965984 -- 35,847,503(-) CATAC(C/T)TCATT downstream-variant-500B
rs1048751 -- 35,844,523(+) GGTCG(C/T)GGGGG synonymous-codon, reference
rs1063307 -- 35,824,108(+) TGGAG(A/C/T)CGATA frameshift-variant
rs1804624 -- 35,844,520(+) AGAGG(C/T)CGTGG synonymous-codon, reference
rs1809490 -- 35,831,279(-) CAGGC(A/G)CCCGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAF15 Gene

Variant ID Type Subtype PubMed ID
nsv908081 CNV Loss 21882294

Relevant External Links for TAF15 Gene

HapMap Linkage Disequilibrium report
TAF15
Human Gene Mutation Database (HGMD)
TAF15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF15 Gene

Disorders for TAF15 Gene

(1) OMIM Diseases for TAF15 Gene (601574)

UniProtKB/Swiss-Prot

RBP56_HUMAN
  • Note=A chromosomal aberration involving TAF15/TAF2N is found in a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with NR4A3.

(5) Novoseek inferred disease relationships for TAF15 Gene

Disease -log(P) Hits PubMed IDs
chondrosarcoma 75.7 4
ewings sarcoma 66.8 4
sarcoma 47.9 3
cancer 8.79 1
tumors 1.35 1

Relevant External Links for TAF15

Genetic Association Database (GAD)
TAF15
Human Genome Epidemiology (HuGE) Navigator
TAF15
genes like me logo Genes that share disorders with TAF15: view

Publications for TAF15 Gene

  1. Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes. (PMID: 9795213) Morohoshi F. … Ohki M. (Gene 1998) 2 3 4 23
  2. hTAF(II)68, a novel RNA/ssDNA-binding protein with homology to the pro-oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase II. (PMID: 8890175) Bertolotti A. … Tora L. (EMBO J. 1996) 3 4 23
  3. Cloning and mapping of a human RBP56 gene encoding a putative RNA binding protein similar to FUS/TLS and EWS proteins. (PMID: 8954779) Morohoshi F. … Ohki M. (Genomics 1996) 2 3 4
  4. EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes. (PMID: 9488465) Bertolotti A. … Tora L. (Mol. Cell. Biol. 1998) 3 23
  5. Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation t(9;17)(q22;q11). (PMID: 10602519) Panagopoulos I. … Heim S. (Oncogene 1999) 3 23

Products for TAF15 Gene

  • Addgene plasmids for TAF15

Sources for TAF15 Gene

Back to Top

Content