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Aliases for TAF15 Gene

Aliases for TAF15 Gene

  • TATA-Box Binding Protein Associated Factor 15 2 3 5
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, N, 68kD (RNA-Binding Protein 56) 2 3
  • TAF15 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 68kDa 2 3
  • TAFII68 3 4
  • TAF2N 3 4
  • RBP56 3 4
  • TATA Box-Binding Protein-Associated Factor 2N (RNA-Binding Protein 56) 3
  • TATA Box Binding Protein Associated Factor 15 3
  • 68 KDa TATA-Binding Protein-Associated Factor 4
  • TBP-Associated Factor 15 3
  • RNA-Binding Protein 56 4
  • RBP56/CSMF Fusion 3
  • TAF(II)68 4
  • NPL3 3

External Ids for TAF15 Gene

Previous HGNC Symbols for TAF15 Gene

  • TAF2N

Previous GeneCards Identifiers for TAF15 Gene

  • GC17P033906
  • GC17P036172
  • GC17P033985
  • GC17P034282
  • GC17P031160
  • GC17P034136
  • GC17P030321

Summaries for TAF15 Gene

Entrez Gene Summary for TAF15 Gene

  • This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for TAF15 Gene

TAF15 (TATA-Box Binding Protein Associated Factor 15) is a Protein Coding gene. Diseases associated with TAF15 include chondrosarcoma, extraskeletal myxoid and myxoid chondrosarcoma. Among its related pathways are Transcriptional misregulation in cancer and GPCR Pathway. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is EWSR1.

UniProtKB/Swiss-Prot for TAF15 Gene

  • RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II).

Gene Wiki entry for TAF15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF15 Gene

Genomics for TAF15 Gene

Regulatory Elements for TAF15 Gene

Genomic Location for TAF15 Gene

Chromosome:
17
Start:
35,713,791 bp from pter
End:
35,864,615 bp from pter
Size:
150,825 bases
Orientation:
Plus strand

Genomic View for TAF15 Gene

Genes around TAF15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF15 Gene

Proteins for TAF15 Gene

  • Protein details for TAF15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92804-RBP56_HUMAN
    Recommended name:
    TATA-binding protein-associated factor 2N
    Protein Accession:
    Q92804
    Secondary Accessions:
    • B2R837
    • Q86X94
    • Q92751

    Protein attributes for TAF15 Gene

    Size:
    592 amino acids
    Molecular mass:
    61830 Da
    Quaternary structure:
    • Belongs to the RNA polymerase II (Pol II) transcriptional multiprotein complex, together with the TATA-binding protein (TBP) and other TBP-associated factors (TAF(II)s). Binds SF1.

    Three dimensional structures from OCA and Proteopedia for TAF15 Gene

    Alternative splice isoforms for TAF15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAF15 Gene

Proteomics data for TAF15 Gene at MOPED

Post-translational modifications for TAF15 Gene

  • ADP-ribosylated during genotoxic stress.
  • Dimethylated by PRMT1 at Arg-206 to asymmetric dimethylarginine. The methylation may favor nuclear localization and positive regulation of TAF15 transcriptional activity.
  • Ubiquitination at Lys 306
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TAF15 (TAF15)

No data available for DME Specific Peptides for TAF15 Gene

Domains & Families for TAF15 Gene

Graphical View of Domain Structure for InterPro Entry

Q92804

UniProtKB/Swiss-Prot:

RBP56_HUMAN :
  • Contains 1 RRM (RNA recognition motif) domain.
  • Belongs to the RRM TET family.
  • Contains 1 RanBP2-type zinc finger.
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the RRM TET family.
Similarity:
  • Contains 1 RanBP2-type zinc finger.
genes like me logo Genes that share domains with TAF15: view

Function for TAF15 Gene

Molecular function for TAF15 Gene

UniProtKB/Swiss-Prot Function:
RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II).

Gene Ontology (GO) - Molecular Function for TAF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 19124016
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with TAF15: view
genes like me logo Genes that share phenotypes with TAF15: view

Human Phenotype Ontology for TAF15 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TAF15 Gene

Localization for TAF15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF15 Gene

Nucleus. Cytoplasm. Note=Shuttles from the nucleus to the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAF15 Gene COMPARTMENTS Subcellular localization image for TAF15 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TAF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 19124016
genes like me logo Genes that share ontologies with TAF15: view

Pathways & Interactions for TAF15 Gene

genes like me logo Genes that share pathways with TAF15: view

Interacting Proteins for TAF15 Gene

SIGNOR curated interactions for TAF15 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TAF15 Gene

None

Drugs & Compounds for TAF15 Gene

No Compound Related Data Available

Transcripts for TAF15 Gene

Unigene Clusters for TAF15 Gene

TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAF15 Gene

No ASD Table

Relevant External Links for TAF15 Gene

GeneLoc Exon Structure for
TAF15
ECgene alternative splicing isoforms for
TAF15

Expression for TAF15 Gene

mRNA expression in normal human tissues for TAF15 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TAF15 Gene



SOURCE GeneReport for Unigene cluster for TAF15 Gene Hs.402752

mRNA Expression by UniProt/SwissProt for TAF15 Gene

Q92804-RBP56_HUMAN
Tissue specificity: Ubiquitous. Observed in all fetal and adult tissues.
genes like me logo Genes that share expression patterns with TAF15: view

Protein tissue co-expression partners for TAF15 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for TAF15 Gene

Orthologs for TAF15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAF15 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Taf15 35
  • 93.28 (n)
  • 95.15 (a)
Taf15 16
chimpanzee
(Pan troglodytes)
Mammalia TAF15 35
  • 99.77 (n)
  • 99.66 (a)
chicken
(Gallus gallus)
Aves TAF15 35
  • 78.44 (n)
  • 78.96 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5964 35
taf15 35
  • 67.54 (n)
  • 66.84 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.22119 35
zebrafish
(Danio rerio)
Actinopterygii wufa11g05 35
Species with no ortholog for TAF15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAF15 Gene

ENSEMBL:
Gene Tree for TAF15 (if available)
TreeFam:
Gene Tree for TAF15 (if available)

Paralogs for TAF15 Gene

Paralogs for TAF15 Gene

(3) SIMAP similar genes for TAF15 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TAF15: view

Variants for TAF15 Gene

Sequence variations from dbSNP and Humsavar for TAF15 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs965984 -- 35,847,503(-) CATAC(C/T)TCATT downstream-variant-500B
rs1804624 -- 35,844,520(+) AGAGG(C/T)CGTGG reference, synonymous-codon
rs1809490 -- 35,831,279(-) CAGGC(A/G)CCCGC intron-variant
rs1048751 -- 35,844,523(+) GGTCG(C/T)GGGGG reference, synonymous-codon
rs2073627 -- 35,844,435(+) TTTAC(A/C/G)TTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAF15 Gene

Variant ID Type Subtype PubMed ID
nsv908081 CNV Loss 21882294

Variation tolerance for TAF15 Gene

Residual Variation Intolerance Score: 28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAF15 Gene

HapMap Linkage Disequilibrium report
TAF15
Human Gene Mutation Database (HGMD)
TAF15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF15 Gene

Disorders for TAF15 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TAF15 Gene - From: OMIM, Orphanet, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chondrosarcoma, extraskeletal myxoid
  • extraskeletal myxoid chondrosarcoma
myxoid chondrosarcoma
chondrosarcoma
  • chondrosarcoma of bone
ewing sarcoma
  • neuroepithelioma
- elite association - COSMIC cancer census association via MalaCards
Search TAF15 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

RBP56_HUMAN
  • Note=A chromosomal aberration involving TAF15/TAF2N is found in a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with NR4A3. {ECO:0000269 PubMed:10602519}.

Relevant External Links for TAF15

Genetic Association Database (GAD)
TAF15
Human Genome Epidemiology (HuGE) Navigator
TAF15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAF15
genes like me logo Genes that share disorders with TAF15: view

No data available for Genatlas for TAF15 Gene

Publications for TAF15 Gene

  1. Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes. (PMID: 9795213) Morohoshi F. … Ohki M. (Gene 1998) 2 3 4 23 67
  2. Diagnostic and therapeutic potential of a human antibody cloned from a cancer patient that binds to a tumor-specific variant of transcription factor TAF15. (PMID: 20048082) Schatz N. … Vollmers H.P. (Cancer Res. 2010) 3 23
  3. The hTAF II 68-TEC fusion protein functions as a strong transcriptional activator. (PMID: 18330902) Kim S. … Kim J. (Int. J. Cancer 2008) 3 23
  4. The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress response. (PMID: 18620564) Andersson M.K. … Aman P. (BMC Cell Biol. 2008) 3 23
  5. Stimulation of hTAFII68 (NTD)-mediated transactivation by v-Src. (PMID: 15094065) Lee H.J. … Kim J. (FEBS Lett. 2004) 3 23

Products for TAF15 Gene

Sources for TAF15 Gene

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