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TAF15 Gene

protein-coding   GIFtS: 64
GCID: GC17P034136

TAF15 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated...

(Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase...)
(Previous symbol: TAF2N)
  See TAF15-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TAF15 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated
Factor, 68kDa1 2
     TATA Box-Binding Protein-Associated Factor 2N (RNA-Binding Protein 56)2
TAF2N1 2 3 5     TATA-Binding Protein-Associated Factor 2N2
RBP562 3 5     TBP-Associated Factor 152
TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, N,
68kD (RNA-Binding Protein 56)1 2
     68 KDa TATA-Binding Protein-Associated Factor3
TAFII682 3     TAF(II)683
Npl32     RNA-Binding Protein 563
RBP56/CSMF Fusion2     

External Ids:    HGNC: 115471   Entrez Gene: 81482   Ensembl: ENSG000001726607   OMIM: 6015745   UniProtKB: Q928043   

Export aliases for TAF15 gene to outside databases

Previous GC identifers: GC17P033906 GC17P036172 GC17P033985 GC17P034282 GC17P031160 GC17P030321


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TAF15 Gene:
This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA
polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation
factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid
chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively
spliced transcript variants encoding multiple isoforms have been observed for this gene. (provided by RefSeq, May
2012)

GeneCards Summary for TAF15 Gene:
TAF15 (TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa) is a protein-coding gene. Diseases associated with TAF15 include myxoid chondrosarcoma, and extraskeletal myxoid chondrosarcoma. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is FUS.

UniProtKB/Swiss-Prot: RBP56_HUMAN, Q92804
Function: RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct
promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II)

Gene Wiki entry for TAF15 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010783.16  NT_187614.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the TAF15 gene promoter:
         AML1a   Pax-5   CUTL1   AP-4   C/EBPalpha   YY1   CHOP-10   Chx10   NF-E2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAF15 promoter sequence
   Search Chromatin IP Primers for TAF15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAF15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.1-q11.2   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q11.1-q11.2

TAF15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAF15 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P034136:  view genomic region     (about GC identifiers)

Start:
34,136,459 bp from pter      End:
34,191,619 bp from pter
Size:
55,161 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RBP56_HUMAN, Q92804 (See protein sequence)
Recommended Name: TATA-binding protein-associated factor 2N  
Size: 592 amino acids; 61830 Da
Subunit: Belongs to the RNA polymerase II (Pol II) transcriptional multiprotein complex, together with the
TATA-binding protein (TBP) and other TBP-associated factors (TAF(II)s). Binds SF1
Secondary accessions: B2R837 Q86X94 Q92751
Alternative splicing: 2 isoforms:  Q92804-1   Q92804-2   

Explore the universe of human proteins at neXtProt for TAF15: NX_Q92804

Explore proteomics data for TAF15 at MOPED

Post-translational modifications: 

  • Dimethylated by PRMT1 at Arg-206 to asymmetric dimethylarginine. The methylation may favor nuclear localization
    and positive regulation of TAF15 transcriptional activity1
  • ADP-ribosylated during genotoxic stress1
  • Ubiquitination2 at Lys306
  • Modification sites at PhosphoSitePlus

  • See TAF15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_003478.1  NP_631961.1  

    ENSEMBL proteins: 
     ENSP00000466950   ENSP00000465961   ENSP00000465098   ENSP00000467450   ENSP00000466955  
     ENSP00000467528   ENSP00000309558   ENSP00000465541   ENSP00000466734  

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    Novus Biologicals TAF15 Protein
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    Cloud-Clone Corp. Proteins for TAF15

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    3 InterPro protein domains:
     IPR001876 Znf_RanBP2
     IPR000504 RRM_dom
     IPR012677 Nucleotide-bd_a/b_plait

    Graphical View of Domain Structure for InterPro Entry Q92804

    ProtoNet protein and cluster: Q92804

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB001876 Zn-finger


    UniProtKB/Swiss-Prot: RBP56_HUMAN, Q92804
    Similarity: Belongs to the RRM TET family
    Similarity: Contains 1 RanBP2-type zinc finger
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Find genes that share domains with TAF15           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RBP56_HUMAN, Q92804
    Function: RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct
    promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II)

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI19124016
         
    Find genes that share ontologies with TAF15           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for TAF15:
     Decreased cell number, increas  Decreased viability of wild-ty  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TAF15
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    miRNA
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    miRTarBase miRNAs that target TAF15:
    hsa-mir-125b-5p (MIRT046039), hsa-mir-196a-5p (MIRT048160), hsa-mir-320a (MIRT044517), hsa-mir-132-3p (MIRT021732), hsa-mir-181a-5p (MIRT025067), hsa-mir-24-3p (MIRT030412), hsa-mir-16-5p (MIRT031463), hsa-mir-615-3p (MIRT040091), hsa-mir-501-5p (MIRT041143), hsa-mir-10a-5p (MIRT047604), hsa-mir-877-3p (MIRT037061)

    Block miRNA regulation of human, mouse, rat TAF15 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TAF15 (see all 26):
    hsa-miR-3128 hsa-miR-16-2* hsa-miR-137 hsa-miR-15a hsa-miR-25 hsa-miR-1271 hsa-miR-1260b hsa-miR-16-1*
    SwitchGear 3'UTR luciferase reporter plasmidTAF15 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TAF15

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    Addgene plasmids for TAF15 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF15


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RBP56_HUMAN, Q92804: Nucleus. Cytoplasm. Note=Shuttles from the nucleus to the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    golgi apparatus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA19124016

    Find genes that share ontologies with TAF15           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TAF15 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Assembly of RNA Polymerase-II Initiation Complex
    Assembly of RNA Polymerase-II Initiation Complex0.91
    Basal transcription factors0.50
    Transcription of mRNA0.91
    Crosstalk Between CARM1 and ESRs0.39
    Protein Acetylation and Deacetylation0.51
    2Apoptotic Pathways in Synovial Fibroblasts
    Nuclear Receptor Activation by Vitamin-A0.57
    3GPCR Pathway
    Estrogen Pathway0.55
    4PEDF Induced Signaling
    Glucocorticoid Receptor Signaling0.43
    5Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer


    Find genes that share SuperPaths with TAF15           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TAF15 (see all 7)
        Nuclear Receptor Activation by Vitamin-A
    Protein Acetylation and Deacetylation
    Assembly of RNA Polymerase-II Initiation Complex
    Glucocorticoid Receptor Signaling
    Estrogen Pathway

    1 GeneGo (Thomson Reuters) Pathway for TAF15
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    2 Kegg Pathways  (Kegg details for TAF15):
        Basal transcription factors
    Transcriptional misregulation in cancer

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TAF15
    Interactions:

        GeneGlobe Interaction Network for TAF15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TAF15 (Q928041, 2, 3 ENSP000003095584) via UniProtKB, MINT, STRING, and/or I2D (see all 652)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST2H4AP628053, ENSP000003581624I2D: score=1 STRING: ENSP00000358162
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0045893positive regulation of transcription, DNA-templated TAS19124016

    Find genes that share ontologies with TAF15           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TAF15 (RBP56)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TAF15 gene (2 alternative transcripts): 
    NM_003487.3  NM_139215.2  

    Unigene Cluster for TAF15:

    TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
    Hs.402752  [show with all ESTs]
    Unigene Representative Sequence: NM_139215
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000588240 ENST00000590273 ENST00000592969 ENST00000588441 ENST00000587272
    ENST00000591957 ENST00000590051 ENST00000592237 ENST00000311979(uc010ctw.1 uc002hkc.3 uc002hkd.3)
    ENST00000591527 ENST00000591763 ENST00000586970 ENST00000585577 ENST00000586593
    ENST00000586104
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TAF15 (see all 26):
    hsa-miR-3128 hsa-miR-16-2* hsa-miR-137 hsa-miR-15a hsa-miR-25 hsa-miR-1271 hsa-miR-1260b hsa-miR-16-1*
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    Inhib. RNA
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    Addgene plasmids for TAF15 
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      QuantiTect SYBR Green Assays in human, mouse, rat TAF15
      QuantiFast Probe-based Assays in human, mouse, rat TAF15

    Additional mRNA sequence: 

    AK000942.1 AK130999.1 AK304520.1 AK307637.1 AK313223.1 AK314194.1 BC030591.2 BC039129.1 
    BC046099.1 BC048985.1 U51334.1 X98893.1 

    21 DOTS entries:

    DT.212660  DT.95125326  DT.100777303  DT.91768446  DT.92066613  DT.120906110  DT.75169741  DT.120906141 
    DT.95358439  DT.101962968  DT.91768444  DT.91973540  DT.100023625  DT.120906140  DT.120906190  DT.306380 
    DT.91768450  DT.92004256  DT.95125327  DT.95253068  DT.120906127 

    Selected AceView cDNA sequences (see all 216):

    AA908468 BC039129 AI636891 AU077342 NM_139215 NM_003487 AI301573 BQ930869 
    AW104422 BU543375 BM848308 AI581076 AK130999 BE671762 AA807199 BF732740 
    BU688925 BF724572 BU192829 BQ229196 BM835571 BC030591 BU543864 BC046099 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TAF15 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
    SP1:                                                              -           -                                                               
    SP2:                                -                             -                                                                           
    SP3:                                                                                                                                          
    SP4:                                                                                                                                          
    SP5:                                      -                                                                                                   


    ECgene alternative splicing isoforms for TAF15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    TAF15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCCATAGTG
    TAF15 Expression
    About this image


    TAF15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Ovary (Reproductive System)
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    TAF15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TAF15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.402752

    UniProtKB/Swiss-Prot: RBP56_HUMAN, Q92804
    Tissue specificity: Ubiquitous. Observed in all fetal and adult tissues

        Custom PCR Arrays for TAF15
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TAF15 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Taf151 , 5 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated more1, 5 93.28(n)1
    95.15(a)1
      11 (50.49 cM)5
    704391  NM_027427.21  NP_081703.11 
     834730865 
    chicken
    (Gallus gallus)
    Aves TAF151 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated more 78.44(n)
    78.96(a)
      417522  XM_415770.4  XP_415770.2 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.221192 Xenopus laevis transcribed sequence with moderate similarity more 77.34(n)    CA973773.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa11g052 wufa11g05 75.05(n)   335009  CD754117.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta caz6
    CG147186
    --
    37(a)
    22(a)
    many ↔ many
    many ↔ many
    X(16182879-16187553)
    3R(7526336-7528442)


    ENSEMBL Gene Tree for TAF15 (if available)
    TreeFam Gene Tree for TAF15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TAF15 gene
    FUS2  EWSR12  
    3 SIMAP similar genes for TAF15 using alignment to 8 protein entries:     RBP56_HUMAN (see all proteins):
    HNRNPA1    FUS    EWSR1

    Find genes that share paralogs with TAF15           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TAF15 (see all 991)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1433159281,2
    C--30352457(+) CTCCCA/GAGTAG 2 -- int10--------
    rs762428501,2
    C--30352475(+) TACAGC/GTACAT 2 -- int10--------
    rs1488259491,2
    --30352492(+) ACGCCC/TGGCTA 2 -- int10--------
    rs1850711801,2
    --30352560(+) ATCTCC/TTGACC 2 -- int10--------
    rs1877208101,2
    --30352578(+) CCACCC/TGCCTC 2 -- int10--------
    rs1159563621,2
    C,F--30352681(+) ACCACC/TGCACT 2 -- int11Minor allele frequency- T:0.10WA 118
    rs557540091,2
    C--34140122(+) AAAAA-/AAAAA 
     AAAAAAA
    GATCA
    2 -- int10--------
    rs42517411,2
    C,F--34148568(+) AATGTA/-AACTA 2 -- int11Minor allele frequency- -:0.20NS 174
    rs594171801,2
    C--34151926(+) ACTGT-/AAAAAAA 2 -- int10--------
    rs58201261,2
    C--34152958(+) GTCTC-/AAAAAA 2 -- int1 trp30--------

    HapMap Linkage Disequilibrium report for TAF15 (34136459 - 34191619 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TAF15:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908081CNV Loss21882294

    Human Gene Mutation Database (HGMD): TAF15
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TAF15
    DNA2.0 Custom Variant and Variant Library Synthesis for TAF15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601574   
    OMIM disorders: 612237  
    UniProtKB/Swiss-Prot: RBP56_HUMAN, Q92804
  • Note=A chromosomal aberration involving TAF15/TAF2N is found in a form of extraskeletal myxoid
    chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with NR4A3

  • 7 diseases for TAF15:    
    About MalaCards
    myxoid chondrosarcoma    extraskeletal myxoid chondrosarcoma    bubonic plague    chondrosarcoma
    acute leukemia    peripheral primitive neuroectodermal tumor    amyotrophic lateral sclerosis

    3 diseases from the University of Copenhagen DISEASES database for TAF15:
    Chondrosarcoma     Amyotrophic lateral sclerosis     Peripheral primitive neuroectodermal tumor

    Find genes that share disorders with TAF15           About GenesLikeMe

    5 Novoseek inferred disease relationships for TAF15 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chondrosarcoma 75.7 6 10537274 (1), 10602519 (1), 11156374 (1), 18330902 (1)
    ewings sarcoma 66.8 4 17106916 (2), 12359745 (1), 18330902 (1)
    sarcoma 47.9 3 8890175 (1), 10602519 (1), 18620564 (1)
    cancer 8.79 1 15094065 (1)
    tumors 1.35 1 12378528 (1)

    Genetic Association Database (GAD): TAF15
    Human Genome Epidemiology (HuGE) Navigator: TAF15 (2 documents)

    Export disorders for TAF15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TAF15 gene, integrated from 10 sources (see all 78):
    (articles sorted by number of sources associating them with TAF15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes. (PubMed id 9795213)1, 2, 3, 9 Morohoshi F.... Ohki M. (Gene 1998)
    2. Cloning and mapping of a human RBP56 gene encoding a putative RNA binding protein similar to FUS/TLS and EWS proteins. (PubMed id 8954779)1, 2, 3 Morohoshi F.... Ohki M. (Genomics 1996)
    3. hTAF(II)68, a novel RNA/ssDNA-binding protein with homology to the pro-oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase II. (PubMed id 8890175)1, 2, 9 Bertolotti A.... Tora L. (EMBO J. 1996)
    4. Proteome-wide identification of poly(ADP-Ribosyl)ation targets in different genotoxic stress responses. (PubMed id 24055347)1, 2 Jungmichel S....Nielsen M.L. (Mol. Cell 2013)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. PRMT1 mediated methylation of TAF15 is required for its positive gene regulatory function. (PubMed id 19124016)1, 2 Jobert L.... Tora L. (Exp. Cell Res. 2009)
    7. The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription. (PubMed id 9660765)1, 2 Zhang D.... Childs G. (J. Biol. Chem. 1998)
    8. Stimulation of hTAFII68 (NTD)-mediated transactivation by v-Src. (PubMed id 15094065)1, 9 Lee H.J....Kim J. (FEBS Lett. 2004)
    9. EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes. (PubMed id 9488465)1, 9 Bertolotti A....Tora L. (Mol. Cell. Biol. 1998)
    10. Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation t(9;17)(q22;q11). (PubMed id 10602519)1, 9 Panagopoulos I.... Heim S. (Oncogene 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8148 HGNC: 11547 AceView: TAF15 Ensembl:ENSG00000172660 euGenes: HUgn8148
    ECgene: TAF15 Kegg: 8148 H-InvDB: TAF15

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TAF15 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TAF15 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/taf15/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TAF15 gene:
    Search GeneIP for patents involving TAF15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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