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Aliases for TAF15 Gene

Aliases for TAF15 Gene

  • TATA-Box Binding Protein Associated Factor 15 2 3 5
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, N, 68kD (RNA-Binding Protein 56) 2 3
  • TAF15 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 68kDa 2 3
  • TAFII68 3 4
  • TAF2N 3 4
  • RBP56 3 4
  • TATA Box-Binding Protein-Associated Factor 2N (RNA-Binding Protein 56) 3
  • 68 KDa TATA-Binding Protein-Associated Factor 4
  • TATA-Binding Protein-Associated Factor 2N 3
  • TBP-Associated Factor 15 3
  • RNA-Binding Protein 56 4
  • RBP56/CSMF Fusion 3
  • TAF(II)68 4
  • NPL3 3

External Ids for TAF15 Gene

Previous HGNC Symbols for TAF15 Gene

  • TAF2N

Previous GeneCards Identifiers for TAF15 Gene

  • GC17P033906
  • GC17P036172
  • GC17P033985
  • GC17P034282
  • GC17P031160
  • GC17P034136
  • GC17P030321

Summaries for TAF15 Gene

Entrez Gene Summary for TAF15 Gene

  • This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

GeneCards Summary for TAF15 Gene

TAF15 (TATA-Box Binding Protein Associated Factor 15) is a Protein Coding gene. Diseases associated with TAF15 include Chondrosarcoma, Extraskeletal Myxoid and Myxoid Chondrosarcoma. Among its related pathways are PEDF Induced Signaling and GPCR Pathway. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is FUS.

UniProtKB/Swiss-Prot for TAF15 Gene

  • RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II).

Gene Wiki entry for TAF15 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF15 Gene

Genomics for TAF15 Gene

Regulatory Elements for TAF15 Gene

Enhancers for TAF15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G035888 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +177.5 177458 5.5 PKNOX1 SIN3A BMI1 YY1 ZNF207 RELB ETV6 IKZF2 ZNF263 ZNF362 CCL3 CCL4 CCL3L3 CCL3L1 TAF15 GAS2L2 C17orf50 HEATR9 CCL5 SLFN12L
GH17G035878 1.4 Ensembl ENCODE dbSUPER 12 +166.1 166104 3.2 HDGF TBP PKNOX1 EGR1 GATA2 ZNF143 RELB ETV6 IKZF2 CREM C17orf50 TAF15 GAS2L2 CCL5 ENSG00000270240
GH17G035783 1.4 Ensembl ENCODE dbSUPER 11.4 +72.7 72694 6.9 TBP ZSCAN4 ZNF133 KLF17 RAD21 ZEB1 YY1 RCOR1 FOS CEBPB C17orf50 GAS2L2 TAF15 RASL10B MMP28 RDM1 HEATR9 GC17P035762
GH17G035875 1.3 Ensembl ENCODE dbSUPER 11.6 +162.6 162550 2.2 BCOR ELF3 HDGF ZMYM3 THRB RARA TEAD3 CTBP1 NR2F6 ETV6 TAF15 ENSG00000267744 CCL14 HEATR9 CCL5 ENSG00000270240
GH17G035895 1.7 FANTOM5 Ensembl ENCODE dbSUPER 8.6 +185.5 185512 8.1 PKNOX1 FEZF1 RAD21 FOS RELB ETV6 IKZF2 ZNF680 CBFB CEBPB C17orf50 CCL5 GAS2L2 TAF15 HEATR9 SLFN12L SLFN14 PIR57610 GC17M035909 GC17M035888
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAF15 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAF15 Gene

Chromosome:
17
Start:
35,713,791 bp from pter
End:
35,864,615 bp from pter
Size:
150,825 bases
Orientation:
Plus strand

Genomic View for TAF15 Gene

Genes around TAF15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF15 Gene

Proteins for TAF15 Gene

  • Protein details for TAF15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92804-RBP56_HUMAN
    Recommended name:
    TATA-binding protein-associated factor 2N
    Protein Accession:
    Q92804
    Secondary Accessions:
    • B2R837
    • Q86X94
    • Q92751

    Protein attributes for TAF15 Gene

    Size:
    592 amino acids
    Molecular mass:
    61830 Da
    Quaternary structure:
    • Belongs to the RNA polymerase II (Pol II) transcriptional multiprotein complex, together with the TATA-binding protein (TBP) and other TBP-associated factors (TAF(II)s). Binds SF1.

    Three dimensional structures from OCA and Proteopedia for TAF15 Gene

    Alternative splice isoforms for TAF15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAF15 Gene

Post-translational modifications for TAF15 Gene

  • ADP-ribosylated during genotoxic stress.
  • Dimethylated by PRMT1 at Arg-206 to asymmetric dimethylarginine. The methylation may favor nuclear localization and positive regulation of TAF15 transcriptional activity.
  • Ubiquitination at Lys306
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TAF15 (TAF15)
  • Abcam antibodies for TAF15

No data available for DME Specific Peptides for TAF15 Gene

Domains & Families for TAF15 Gene

Graphical View of Domain Structure for InterPro Entry

Q92804

UniProtKB/Swiss-Prot:

RBP56_HUMAN :
  • Belongs to the RRM TET family.
Family:
  • Belongs to the RRM TET family.
genes like me logo Genes that share domains with TAF15: view

Function for TAF15 Gene

Molecular function for TAF15 Gene

UniProtKB/Swiss-Prot Function:
RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II).

Gene Ontology (GO) - Molecular Function for TAF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IDA,IEA 22658674
GO:0005515 protein binding IPI 19124016
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TAF15: view
genes like me logo Genes that share phenotypes with TAF15: view

Human Phenotype Ontology for TAF15 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TAF15

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TAF15 Gene

Localization for TAF15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF15 Gene

Nucleus. Cytoplasm. Note=Shuttles from the nucleus to the cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAF15 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TAF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 19124016
GO:0005654 nucleoplasm IDA --
GO:0005730 NOT nucleolus IDA 19124016
GO:0005737 cytoplasm IDA,IEA 19124016
genes like me logo Genes that share ontologies with TAF15: view

Pathways & Interactions for TAF15 Gene

genes like me logo Genes that share pathways with TAF15: view

SIGNOR curated interactions for TAF15 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TAF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045893 positive regulation of transcription, DNA-templated TAS 19124016
genes like me logo Genes that share ontologies with TAF15: view

Transcripts for TAF15 Gene

Unigene Clusters for TAF15 Gene

TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TAF15

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAF15 Gene

No ASD Table

Relevant External Links for TAF15 Gene

GeneLoc Exon Structure for
TAF15
ECgene alternative splicing isoforms for
TAF15

Expression for TAF15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAF15 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TAF15 Gene



Protein tissue co-expression partners for TAF15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TAF15 Gene:

TAF15

SOURCE GeneReport for Unigene cluster for TAF15 Gene:

Hs.402752

mRNA Expression by UniProt/SwissProt for TAF15 Gene:

Q92804-RBP56_HUMAN
Tissue specificity: Ubiquitous. Observed in all fetal and adult tissues.

Evidence on tissue expression from TISSUES for TAF15 Gene

  • Liver(4.5)
  • Nervous system(3.7)
  • Spleen(2.7)
  • Heart(2.6)
  • Kidney(2.5)
  • Muscle(2.5)
  • Lung(2.4)
  • Intestine(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TAF15 Gene

Germ Layers:
  • mesoderm
Systems:
  • skeleton
Organs:
Head and neck:
  • head
  • jaw
  • mandible
  • maxilla
  • mouth
  • neck
  • skull
Thorax:
  • chest wall
  • clavicle
  • rib
  • rib cage
  • scapula
  • sternum
Pelvis:
  • pelvis
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
General:
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with TAF15: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for TAF15 Gene

Orthologs for TAF15 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TAF15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF15 34
  • 99.77 (n)
mouse
(Mus musculus)
Mammalia Taf15 34 16
  • 93.28 (n)
chicken
(Gallus gallus)
Aves TAF15 34
  • 78.44 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia taf15 34
  • 67.54 (n)
Str.5964 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.22119 34
zebrafish
(Danio rerio)
Actinopterygii wufa11g05 34
Species where no ortholog for TAF15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TAF15 Gene

ENSEMBL:
Gene Tree for TAF15 (if available)
TreeFam:
Gene Tree for TAF15 (if available)

Paralogs for TAF15 Gene

Paralogs for TAF15 Gene

(3) SIMAP similar genes for TAF15 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for TAF15 Gene

genes like me logo Genes that share paralogs with TAF15: view

Variants for TAF15 Gene

Sequence variations from dbSNP and Humsavar for TAF15 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000034907 -- 35,814,669(+) TCAAC(A/G)TGGTG intron-variant
rs1000047034 -- 35,837,344(+) AGATG(G/T)AGTCT intron-variant
rs1000086895 -- 35,814,444(+) ATTAC(A/C)GGCGT intron-variant
rs1000114699 -- 35,831,763(+) AGTTC(-/T)TTTTT intron-variant
rs1000177813 -- 35,830,907(+) GACAG(A/T)CCCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAF15 Gene

Variant ID Type Subtype PubMed ID
esv3892999 CNV loss 25118596
nsv1059795 CNV gain 25217958
nsv1079030 OTHER inversion 25765185

Variation tolerance for TAF15 Gene

Residual Variation Intolerance Score: 28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAF15 Gene

Human Gene Mutation Database (HGMD)
TAF15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAF15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF15 Gene

Disorders for TAF15 Gene

MalaCards: The human disease database

(5) MalaCards diseases for TAF15 Gene - From: OMIM, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
chondrosarcoma, extraskeletal myxoid
  • extraskeletal myxoid chondrosarcoma
myxoid chondrosarcoma
chondrosarcoma
  • chondrosarcoma of bone
extraosseous chondrosarcoma
  • extraskeletal myxoid chondrosarcoma
ewing sarcoma
  • neuroepithelioma
- elite association - COSMIC cancer census association via MalaCards
Search TAF15 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

RBP56_HUMAN
  • Note=A chromosomal aberration involving TAF15/TAF2N is found in a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with NR4A3. {ECO:0000269 PubMed:10602519}.

Relevant External Links for TAF15

Genetic Association Database (GAD)
TAF15
Human Genome Epidemiology (HuGE) Navigator
TAF15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAF15
genes like me logo Genes that share disorders with TAF15: view

No data available for Genatlas for TAF15 Gene

Publications for TAF15 Gene

  1. Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes. (PMID: 9795213) Morohoshi F. … Ohki M. (Gene 1998) 2 3 4 22 64
  2. Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with translocation t(9;17)(q22;q11). (PMID: 10602519) Panagopoulos I. … Heim S. (Oncogene 1999) 3 4 22 64
  3. Cloning and mapping of a human RBP56 gene encoding a putative RNA binding protein similar to FUS/TLS and EWS proteins. (PMID: 8954779) Morohoshi F. … Ohki M. (Genomics 1996) 2 3 4 64
  4. hTAF(II)68, a novel RNA/ssDNA-binding protein with homology to the pro-oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase II. (PMID: 8890175) Bertolotti A. … Tora L. (EMBO J. 1996) 3 4 22 64
  5. Proteome-wide identification of poly(ADP-Ribosyl)ation targets in different genotoxic stress responses. (PMID: 24055347) Jungmichel S. … Nielsen M.L. (Mol. Cell 2013) 3 4 64

Products for TAF15 Gene

Sources for TAF15 Gene

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