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Aliases for TAF13 Gene

Aliases for TAF13 Gene

  • TATA-Box Binding Protein Associated Factor 13 2 3 5
  • TAF13 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 18kDa 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, K, 18kD 2 3
  • Transcription Initiation Factor TFIID 18 KDa Subunit 3 4
  • TAF(II)18 3 4
  • TAFII-18 3 4
  • TAFII18 3 4
  • TAF2K 3 4
  • Transcription Initiation Factor TFIID 18 KD Subunit 3
  • Transcription Initiation Factor TFIID Subunit 13 3
  • MRT60 3

External Ids for TAF13 Gene

Previous HGNC Symbols for TAF13 Gene

  • TAF2K

Previous GeneCards Identifiers for TAF13 Gene

  • GC01M110076
  • GC01M9C0097
  • GC01U900282
  • GC00M9T0035
  • GC01M109318
  • GC01M109406
  • GC01M109605
  • GC01M107499

Summaries for TAF13 Gene

Entrez Gene Summary for TAF13 Gene

  • Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit associated with a subset of TFIID complexes. This subunit interacts with TBP and with two other small subunits of TFIID, TAF10 and TAF11. There is a pseudogene located on chromosome 6. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAF13 Gene

TAF13 (TATA-Box Binding Protein Associated Factor 13) is a Protein Coding gene. Diseases associated with TAF13 include Mental Retardation, Autosomal Recessive 60. Among its related pathways are Formation of HIV elongation complex in the absence of HIV Tat and HIV Life Cycle. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein C-terminus binding.

UniProtKB/Swiss-Prot for TAF13 Gene

  • TFIID beta-specific TAFII.

Gene Wiki entry for TAF13 Gene

Additional gene information for TAF13 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF13 Gene

Genomics for TAF13 Gene

Regulatory Elements for TAF13 Gene

Enhancers for TAF13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H109074 1.1 ENCODE 9.6 +0.1 79 2.3 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 CLCC1 TAF13 RANP5
GH01H109049 0.6 ENCODE 17.3 +25.5 25458 1.3 PKNOX1 ZNF217 ZNF121 GATA3 CTBP1 ZBTB33 FOS FOSL2 TCF7L2 TAF13 TMEM167B RANP5
GH01H108961 1.1 ENCODE 5.7 +112.8 112811 2.6 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 PRPF38B GNAI3 RPL17P7 RPS27P6 C1orf194 WDR47 TAF13 ENSG00000274068 GC01P108959
GH01H109079 1.4 Ensembl ENCODE dbSUPER 0.7 -4.2 -4233 1.4 TBP HDGF PKNOX1 ARNT NFRKB DMAP1 EGR1 POLR3A ATF7 SMARCA5 C1orf194 ENSG00000258634 CLCC1 STRIP1 ATXN7L2 TAF13 TMEM167B
GH01H109084 0.6 ENCODE 0.4 -8.8 -8782 0 ZNF362 ZEB2 ZNF384 DPF2 GABPA ZSCAN21 FOSL1 NBN TAF13 TMEM167B
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAF13 on UCSC Golden Path with GeneCards custom track

Promoters for TAF13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000011023 402 1601 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Genomic Locations for TAF13 Gene

Genomic Locations for TAF13 Gene
chr1:109,062,486-109,076,002
(GRCh38/hg38)
Size:
13,517 bases
Orientation:
Minus strand
chr1:109,605,108-109,618,624
(GRCh37/hg19)

Genomic View for TAF13 Gene

Genes around TAF13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF13 Gene

Proteins for TAF13 Gene

  • Protein details for TAF13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15543-TAF13_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 13
    Protein Accession:
    Q15543
    Secondary Accessions:
    • B2R5E5
    • Q5TYV6

    Protein attributes for TAF13 Gene

    Size:
    124 amino acids
    Molecular mass:
    14287 Da
    Quaternary structure:
    • TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts with TBP, and more strongly with TAF10 and TAF11.

    Three dimensional structures from OCA and Proteopedia for TAF13 Gene

neXtProt entry for TAF13 Gene

Post-translational modifications for TAF13 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAF13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAF13 Gene

Domains & Families for TAF13 Gene

Gene Families for TAF13 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TAF13 Gene

Graphical View of Domain Structure for InterPro Entry

Q15543

UniProtKB/Swiss-Prot:

TAF13_HUMAN :
  • The binding of TAF10 and TAF11 requires distinct domains of TAF13.
  • Belongs to the TAF13 family.
Domain:
  • The binding of TAF10 and TAF11 requires distinct domains of TAF13.
Family:
  • Belongs to the TAF13 family.
genes like me logo Genes that share domains with TAF13: view

Function for TAF13 Gene

Molecular function for TAF13 Gene

UniProtKB/Swiss-Prot Function:
TFIID beta-specific TAFII.

Gene Ontology (GO) - Molecular Function for TAF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IBA --
GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 9695952
GO:0003712 transcription cofactor activity IBA --
GO:0005515 protein binding IPI 7729427
GO:0008022 protein C-terminus binding IPI 7729427
genes like me logo Genes that share ontologies with TAF13: view
genes like me logo Genes that share phenotypes with TAF13: view

Animal Model Products

miRNA for TAF13 Gene

miRTarBase miRNAs that target TAF13

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAF13 Gene

Localization for TAF13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF13 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAF13 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (4)
  • Nucleus (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TAF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex NAS 9695952
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with TAF13: view

Pathways & Interactions for TAF13 Gene

genes like me logo Genes that share pathways with TAF13: view

Gene Ontology (GO) - Biological Process for TAF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006352 DNA-templated transcription, initiation NAS 9695952
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with TAF13: view

No data available for SIGNOR curated interactions for TAF13 Gene

Drugs & Compounds for TAF13 Gene

No Compound Related Data Available

Transcripts for TAF13 Gene

mRNA/cDNA for TAF13 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(73) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TAF13 Gene

TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAF13 Gene

No ASD Table

Relevant External Links for TAF13 Gene

GeneLoc Exon Structure for
TAF13
ECgene alternative splicing isoforms for
TAF13

Expression for TAF13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAF13 Gene

Protein differential expression in normal tissues from HIPED for TAF13 Gene

This gene is overexpressed in Fetal Brain (39.3) and Placenta (29.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TAF13 Gene



Protein tissue co-expression partners for TAF13 Gene

NURSA nuclear receptor signaling pathways regulating expression of TAF13 Gene:

TAF13

SOURCE GeneReport for Unigene cluster for TAF13 Gene:

Hs.632426

Evidence on tissue expression from TISSUES for TAF13 Gene

  • Nervous system(4.4)
  • Liver(2)
genes like me logo Genes that share expression patterns with TAF13: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAF13 Gene

Orthologs for TAF13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TAF13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF13 33 34
  • 100 (n)
oppossum
(Monodelphis domestica)
Mammalia TAF13 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAF13 33 34
  • 95.7 (n)
cow
(Bos Taurus)
Mammalia TAF13 33 34
  • 94.35 (n)
mouse
(Mus musculus)
Mammalia Taf13 33 16 34
  • 90.32 (n)
chicken
(Gallus gallus)
Aves TAF13 33 34
  • 82.65 (n)
lizard
(Anolis carolinensis)
Reptilia TAF13 34
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia taf13 33
  • 78.91 (n)
Str.6597 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.4615 33
zebrafish
(Danio rerio)
Actinopterygii taf13 33 34
  • 74.15 (n)
wufc20d03 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1879 33
fruit fly
(Drosophila melanogaster)
Insecta Taf13 35 33 34
  • 67.72 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008045 33
  • 65.29 (n)
worm
(Caenorhabditis elegans)
Secernentea taf-13 33 34
  • 58.7 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF13 34 36
  • 17 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons TAF13 33
  • 63.04 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5080 34
  • 66 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4198 33
Species where no ortholog for TAF13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAF13 Gene

ENSEMBL:
Gene Tree for TAF13 (if available)
TreeFam:
Gene Tree for TAF13 (if available)

Paralogs for TAF13 Gene

(1) SIMAP similar genes for TAF13 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TAF13 Gene

genes like me logo Genes that share paralogs with TAF13: view

No data available for Paralogs for TAF13 Gene

Variants for TAF13 Gene

Sequence variations from dbSNP and Humsavar for TAF13 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000070937 -- 109,076,050(+) TGGGC(C/T)TAGCC upstream-variant-2KB
rs1000108754 -- 109,065,688(+) GAGGC(A/C/G)GAGGC intron-variant
rs1000121332 -- 109,075,839(+) AAGCA(C/G)ACCCG intron-variant
rs1000458207 -- 109,070,684(+) CCACC(A/G)TACCC intron-variant
rs1000658248 -- 109,069,458(+) GACAA(-/G)GAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAF13 Gene

Variant ID Type Subtype PubMed ID
nsv954947 CNV deletion 24416366
nsv831026 CNV loss 17160897
nsv1119707 CNV deletion 24896259
nsv1078062 CNV deletion 25765185
esv3894001 CNV gain 25118596
esv3587147 CNV loss 21293372
esv2715984 CNV deletion 23290073
esv2715973 CNV deletion 23290073
esv2669667 CNV deletion 23128226

Variation tolerance for TAF13 Gene

Residual Variation Intolerance Score: 48.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.11; 2.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAF13 Gene

Human Gene Mutation Database (HGMD)
TAF13
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAF13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF13 Gene

Disorders for TAF13 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TAF13 Gene - From: OMIM, ClinVar, and Swiss-Prot

Disorder Aliases PubMed IDs
mental retardation, autosomal recessive 60
  • mrt60
- elite association - COSMIC cancer census association via MalaCards
Search TAF13 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TAF13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAF13
genes like me logo Genes that share disorders with TAF13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAF13 Gene

Publications for TAF13 Gene

  1. Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID. (PMID: 7729427) Mengus G … Davidson I (The EMBO journal 1995) 2 3 4 60
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family. (PMID: 9695952) Birck C … Moras D (Cell 1998) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for TAF13 Gene

Sources for TAF13 Gene

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