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TAF13 Gene

protein-coding   GIFtS: 57

GC01M109406
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
(Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase II, K, 18kD )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: TAF2K)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
MGC22425 2
OTTHUMP00000039344 2
TAF(II)18 3
TAF2K 2, 3
TAFII-18 3
TAFII18 1, 2, 3
Descriptions
TAF13 RNA polymerase II, TATA box binding protein
(TBP)-associated factor, 18kDa 2
TAF13 RNA polymerase II, TATA box binding
protein-associated factor, 18kDa 1
TATA box binding protein (TBP)-associated factor, RNA
polymerase II, K, 18kD 1, 2
TBP-associated factor 13 2
Transcription initiation factor TFIID 18 kDa subunit 3
transcription initiation factor TFIID 18 kD subunit 2
External Ids
HGNC: 115461
Entrez Gene: 68842
UniProtKB: Q155433
Ensembl: ENSG000001977807
Search outside databases for aliases for TAF13 gene

Previous GC identifers: GC01M110076 GC01M9C0097 GC01U900282 GC00M9T0035 GC01M109318

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TAF13:
Initiation of transcription by RNA polymerase II requires the activities of more than 70
polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID),
which binds to the core promoter to position the polymerase properly, serves as the scaffold for
assembly of the remainder of the transcription complex, and acts as a channel for regulatory
signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily
conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal
transcription, serve as coactivators, function in promoter recognition or modify general
transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This
gene encodes a small subunit associated with a subset of TFIID complexes. This subunit interacts
with TBP and with two other small subunits of TFIID, TAF10 and TAF11. There is a pseudogene
located on chromosome 6. [provided by RefSeq]

UniProtKB/Swiss-Prot: TAF13_HUMAN, Q15543
Function: TFIID beta-specific TAFII

Gene Wiki entry for TAF13

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the TAF13 gene  

Entrez Gene cytogenetic band: 1p13.3   Ensembl cytogenetic band:  1p13.3   HGNC cytogenetic band: 1p13.3

TAF13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M109406:     (about GC identifiers)

Start:
109,408,521 bp from pter
End:
109,420,147 bp from pter
Size:
11,627 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000001.9  NT_019273.18  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TAF13_HUMAN, Q15543 (See protein sequence)
Recommended Name: Transcription initiation factor TFIID subunit 13  
Size: 124 amino acids; 14287 Da
Subunit: TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors
(TAFs). Interacts with TBP, and more strongly with TAF10 and TAF11
Subcellular location: Nucleus
PDB structure from and Proteopedia :
1BH8 (3D)    1BH9 (3D)    
Secondary accessions: Q5TYV6

REFSEQ proteins: NP_005636.1  

ENSEMBL proteins: 
ENSP00000355051 


Human Recombinant Proteins 
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Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (TAF13)
Human Recombinant Proteins from Abnova (TAF13)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus IEA--
GO:0005654 nucleoplasm EXP1939271 2449431 8946909
GO:0005669 transcription factor TFIID complex TAS7729427
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Antibodies for TAF13: 
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Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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Antibodies from Abcam (TAF13), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (TAF13)
Novus Biologicals Antibodies for TAF13

Assays for TAF13: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro domains/families:
 IPR003195 TFIID-18
 IPR009072 Histone-fold


   GeneDecks  TAF13 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q15543

ProtoNet protein and cluster: Q15543

1 Blocks protein family: IPB003195 Transcription initiation factor IID

UniProtKB/Swiss-Prot: TAF13_HUMAN, Q15543
Domain: The binding of TAF10 and TAF11 requires distinct domains of TAF13
Similarity: Belongs to the TAF13 family
Similarity: Contains 1 histone-fold domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (TAF13)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005645

              Applied Biosystems Silencer® siRNAs for TAF13

              Sigma-Aldrich siRNA for TAF13  
                     Sigma-Aldrich shRNA for TAF13  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005645
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005645
                                 untagged cDNA clones in CMV expression vector (see all 2): BC017821 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_005645

UniProtKB/Swiss-Prot: TAF13_HUMAN, Q15543
Function: TFIID beta-specific TAFII

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003700 transcription factor activity TAS9695952
GO:0005515 protein binding IPI9695952
GO:0016251 general RNA polymerase II transcription factor activity TAS7729427
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Millipore Pathway for TAF13
 Transcription Ligand-Dependent Transcription of Retinoid-Target genes

   GeneDecks  TAF13 for the pathways selected above  
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for  TAF13  (Your Favorite Gene powered by Ingenuity) 
 Estrogen Receptor Signaling
 Glucocorticoid Receptor Signaling

   GeneDecks  TAF13 for the pathways selected above  
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1 Kegg Pathway  (Kegg details for TAF13):
 hsa03022 Basal transcription factors

   GeneDecks  TAF13 for the pathways selected above  
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 Gene Network CentralTM Interacting Genes and Proteins Network for  TAF13 


5/87 Interacting proteins for TAF13 (Q155431, 2 ENSP000003550513) via UniProtKB, MINT, and/or STRING (see all 87 )
InteractantInteraction Details
GeneCardExternal ID(s)
TAF11Q155441, 2, ENSP000003546333EBI-1026992, EBI-1027005 MINT-24883 EBI-1026992, EBI-1027005 MINT-24883 STRING (score=.999)
TAF11Q155441, 2, ENSP000003546333EBI-1026992, EBI-1027005 MINT-24883 EBI-1026992, EBI-1027005 MINT-24883 STRING (score=.999)
TAF11Q155441, 2, ENSP000003546333EBI-1026992, EBI-1027005 MINT-24883 EBI-1026992, EBI-1027005 MINT-24883 STRING (score=.999)
TBPENSP000002303543STRING (score=.998)
TAF10ENSP000002994243STRING (score=.996)
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4 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006350 transcription IEA--
GO:0006355 regulation of transcription, DNA-dependent IEA--
GO:0006367 transcription initiation from RNA polymerase II promoter EXP8946909
GO:0006368 RNA elongation from RNA polymerase II promoter EXP9405375
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TAF13

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (TAF13)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005645

              Sigma-Aldrich siRNA for TAF13  
                     Sigma-Aldrich shRNA for TAF13  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_005645  

REFSEQ mRNAs for TAF13 gene: 

NM_005645.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_005645  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005645
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005645
                                 untagged cDNA clones in CMV expression vector (see all 2): BC017821 

Additional cDNA sequence: 

AK312158.1 BC121180.1 BC121181.1 X84003.1 

5 DOTS entries:

DT.91930042  DT.40125289  DT.95360809  DT.97783253  DT.312637 

24/73 AceView cDNA sequences (see all 73 ):

AI694148 BC017821 AU280379 AA932001 AI469457 AI184437 AI272017 X84003 
BQ018082 BE008049 CB120605 AI056692 CD678712 AA075134 AI382152 AI083950 
BM966987 AI311791 BX283380 BQ775753 N20901 BM967171 BQ438111 BM762538 

highest scoring ESTs for TAF13:

X84003 AU098685 AU280379 BE008049 BE815404 BQ428999 BX283380 BE074293 BE083921 BE083997 

Unigene Cluster for TAF13:

TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
Hs.632426  [show with all ESTs]
Unigene Representative Sequence: BM562327


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000338366  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TAF13 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for TAF13

1 / 2 / 3

4 probe-sets matching TAF13 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

803_at2, 3 U95-A 3 1.00 0.53 0.87 0.72 X84003 1.00 0.90 0.95 1

31729_at2, 3 U95-A 3 0.94 0.61 1.00 1.00 X84003 1.00 0.90 0.95 1

205966_at2, 3 U133-A 3 1.00 0.53 -- -- NM_005645 0.60 1.00 0.82 1

205966_at2 U133Plus2 3 1.00 0.53 -- -- -- -- -- -- --
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TAAATGAAAG

SOURCE GeneReport for Unigene cluster: Hs.632426

Expression variation in blood from EXPOLDB for TAF13

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for TAF13 gene from 5/17 species (see all 17 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
TAF131   -- TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated more 95.97(n)
99.19(a)
476973  XM_534173.2  XP_534173.1 
chimpanzee
(Pan troglodytes)
TAF131   -- TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated more 99.73(n)
100(a)
738503  XM_001146772.1  XP_001146772.1 
cow
(Bos taurus)
TAF131   -- TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated more 94.35(n)
100(a)
513065  NM_001075597.1  NP_001069065.1 
rat
(Rattus norvegicus)
Taf131   -- TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated more 90.59(n)
100(a)
310784  XM_227586.3  XP_227586.1 
mouse
(Mus musculus)
Taf131, 5 35
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated more1, 5 90.32(n)1
100(a)1
997301  NM_025444.21  NP_079720.11 
 AI8472955  AK0072275  (see all 9)
About this table        Species with no ortholog for TAF13

ENSEMBL Gene Tree for TAF13
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for TAF13 gene
LOC7278172  

Pseudogenes
2 related pseudogenes


(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/83 NCBI SNPs in TAF13 are shown (see all 83 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 7)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 1 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
--
rs5221931,2
C109408592(+) TATCAA/GAATCT 1 -- ut31 ese30--------
--
rs66047571,2
C109408638(+) CCCCAA/GATGGT 1 -- ut310--------
--
rs66047601,2
A,C109412930(+) tcaccC/Tgaggt 1 -- int10--------
--
rs15622251,2
C,O109414989(+) AACAAA/CCGACT 1 -- int10--------
rs6733651,2
F109419780(-) TATGAA/GCCAAC 1 -- int14Minor allele frequency- G:0.09EA NA 144
--
rs96974701,2
C109410519(+) CCAAGG/TATGGA 1 -- int10--------
--
rs23589561,2
C109414329(+) ttcctC/Tgactt 1 -- int10--------
--
rs45204411,2
C109417664(+) gcgccA/Gccacg 1 -- int10--------
--
rs724646311,2
--109408327(+) AAAAG-/AACTACA 1 -- ng510--------
--
rs561406571,2
--109408405(+) AGTCAA/GAACAA 1 -- ng510--------
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HapMap Linkage Disequilibrium images for TAF13 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600774

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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10/20 PubMed articles for TAF13 gene (see all 20 ):
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6884 HGNC: 11546 AceView: TAF13 Ensembl:ENSG00000197780 euGenes: HUgn6884
ECgene: TAF13 H-InvDB: TAF13
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for TAF13:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for TAF13 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for TAF13

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