TAF13 Gene
protein-coding GIFtS : 57
GC01M109406
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa (Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase II, K, 18kD )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbol: TAF2K )
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Aliases & Descriptions for TAF13
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases MGC22425 2 OTTHUMP00000039344 2 TAF(II)18 3 TAF2K 2 , 3 TAFII-18 3 TAFII18 1 , 2 , 3
Descriptions TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa 2 TAF13 RNA polymerase II, TATA box binding protein-associated factor, 18kDa 1 TATA box binding protein (TBP)-associated factor, RNA polymerase II, K, 18kD 1 , 2 TBP-associated factor 13 2 Transcription initiation factor TFIID 18 kDa subunit 3 transcription initiation factor TFIID 18 kD subunit 2
Search outside databases for aliases for TAF13 genePrevious GC identifers: GC01M110076 GC01M9C0097 GC01U900282 GC00M9T0035 GC01M109318
Summaries for TAF13 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for TAF13 : Initiation of transcription by RNA polymerase II requires the activities of more than 70polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID),which binds to the core promoter to position the polymerase properly, serves as the scaffold forassembly of the remainder of the transcription complex, and acts as a channel for regulatorysignals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarilyconserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basaltranscription, serve as coactivators, function in promoter recognition or modify generaltranscription factors (GTFs) to facilitate complex assembly and transcription initiation. Thisgene encodes a small subunit associated with a subset of TFIID complexes. This subunit interactswith TBP and with two other small subunits of TFIID, TAF10 and TAF11. There is a pseudogenelocated on chromosome 6. [provided by RefSeq] UniProtKB/Swiss-Prot: TAF13_HUMAN, Q15543 Function : TFIID beta-specific TAFII
Gene Wiki entry for TAF13
Genomic Location for TAF13
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the TAF13 gene Entrez Gene cytogenetic band: 1p13.3 Ensembl cytogenetic band: 1p13.3 HGNC cytogenetic band: 1p13.3 TAF13 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M109406:
(about GC identifiers )
Start:
109,408,521 bp from pter
End:
109,420,147 bp from pter
Size:
11,627 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000001.9 NT_019273.18 Proteins for TAF13
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: TAF13_HUMAN, Q15543 (See
protein sequence )Recommended Name: Transcription initiation factor TFIID subunit 13 Size : 124 amino acids; 14287 Da
Subunit : TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors(TAFs). Interacts with TBP, and more strongly with TAF10 and TAF11
Subcellular location : Nucleus
PDB structure from and Proteopedia : 1BH8 (3D)
 1BH9 (3D)
 
Secondary accessions : Q5TYV6
REFSEQ proteins: NP_005636.1 ENSEMBL proteins: ENSP00000355051 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 3 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for TAF13: Assays for TAF13:
Protein
Domains/ Families for TAF13(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q15543 ProtoNet protein and cluster: Q15543
1 Blocks protein family : IPB003195 Transcription initiation factor IID UniProtKB/Swiss-Prot: TAF13_HUMAN, Q15543 Domain : The binding of TAF10 and TAF11 requires distinct domains of TAF13Similarity : Belongs to the TAF13 familySimilarity : Contains 1 histone-fold domain
Gene Function for TAF13
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005645 Applied Biosystems Silencer ® siRNAs for TAF13 Sigma-Aldrich siRNA for TAF13 Sigma-Aldrich shRNA for TAF13 Explore Sigma-Aldrich super-pooled esiRNAs               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005645                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005645                                  untagged cDNA clones in CMV expression vector (see all 2 ): BC017821  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005645 UniProtKB/Swiss-Prot: TAF13_HUMAN, Q15543 Function : TFIID beta-specific TAFII
3 Gene Ontology (GO) molecular function terms (links to tree view) :
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Pathways & Interactions for TAF13
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for TAF13 (Your Favorite Gene powered by Ingenuity) Gene Network CentralTM Interacting Genes and Proteins Network for TAF13 5/87 Interacting proteins for TAF13 (Q15543 1 , 2 ENSP00000355051 3 ) via UniProtKB, MINT, and/or STRING (see all 87
)Interactant Interaction Details GeneCard External ID(s) TAF11 Q15544 1 , 2 , ENSP00000354633 3 EBI-1026992, EBI-1027005 MINT-24883 EBI-1026992, EBI-1027005 MINT-24883 STRING (score=.999 ) TAF11 Q15544 1 , 2 , ENSP00000354633 3 EBI-1026992, EBI-1027005 MINT-24883 EBI-1026992, EBI-1027005 MINT-24883 STRING (score=.999 ) TAF11 Q15544 1 , 2 , ENSP00000354633 3 EBI-1026992, EBI-1027005 MINT-24883 EBI-1026992, EBI-1027005 MINT-24883 STRING (score=.999 ) TBP ENSP00000230354 3 STRING (score=.998 ) TAF10 ENSP00000299424 3 STRING (score=.996 )
About this table 4 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006350 transcription
IEA -- GO:0006355 regulation of transcription, DNA-dependent
IEA -- GO:0006367 transcription initiation from RNA polymerase II promoter
EXP 8946909 GO:0006368 RNA elongation from RNA polymerase II promoter
EXP 9405375
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Drugs & Compounds for TAF13 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Transcripts for TAF13(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005645 Sigma-Aldrich siRNA for TAF13 Sigma-Aldrich shRNA for TAF13 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_005645
REFSEQ mRNAs for TAF13 gene: NM_005645.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005645
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005645                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005645                                  untagged cDNA clones in CMV expression vector (see all 2 ): BC017821  
Additional cDNA sequence: AK312158.1 BC121180.1 BC121181.1 X84003.1
5 DOTS entries : DT.91930042 DT.40125289 DT.95360809 DT.97783253 DT.312637
24/73 AceView cDNA sequences (see all 73
):AI694148 BC017821 AU280379 AA932001 AI469457 AI184437 AI272017 X84003 BQ018082 BE008049 CB120605 AI056692 CD678712 AA075134 AI382152 AI083950 BM966987 AI311791 BX283380 BQ775753 N20901 BM967171 BQ438111 BM762538
highest scoring ESTs for TAF13 :X84003 AU098685 AU280379 BE008049 BE815404 BQ428999 BX283380 BE074293 BE083921 BE083997
Unigene Cluster for TAF13: TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa Hs.632426 [show with all ESTs ] Unigene Representative Sequence: BM562327 GeneLoc Exon Structure 1 Ensembl transcript including schematic representation : ENST00000338366
Expression for TAF13
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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TAF13 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for TAF13 1 / 2 / 3
4 probe-sets matching TAF13 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TAAATGAAAGSOURCE GeneReport for Unigene cluster: Hs.632426 Expression variation in blood from EXPOLDB for TAF13
Orthologs for TAF13
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for TAF13 gene from 5/17 species (see all 17
)
About this table Species with no ortholog for TAF13 ENSEMBL Gene Tree for TAF13 Paralogs for TAF13 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for TAF13 gene LOC727817 2 Pseudogenes 2 related pseudogenes
SNPs/Variants for TAF13 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for TAF13 (up to first 250kb)
Disorders & Mutations for TAF13
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 600774
Medical News for TAF13 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for TAF13 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/20 PubMed articles for TAF13 gene (see all 20
): Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID. (PubMed id 7729427) 2, 3, 4 Mengus G....Davidson I. (1995) The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414) 3, 4 Gregory S.G.... Bentley D.R. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family. (PubMed id 9695952) 3, 4 Birck C.... Moras D. (1998) Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis. (PubMed id 12878157) 3 Imabayashi H.... Umezawa A. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002) EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes. (PubMed id 9488465) 3 Bertolotti A....Tora L. (1998) Three transitions in the RNA polymerase II transcription complex during initiation. (PubMed id 9405375) 3 Holstege F.C....Timmers H.T. (1997) Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes. (PubMed id 9054383) 3 Garcia-Martinez L.F....Gaynor R.B. (1997) Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex. (PubMed id 8764062) 3 Kashanchi F....Brady J.N. (1996)
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Genome Databases showing TAF13
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing TAF13
(According to HUGE )
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Specialized Databases showing TAF13 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for TAF13 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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