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TAF12 Gene

protein-coding   GIFtS: 58
GCID: GC01M028915

TAF12 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated...

(Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase...)
(Previous symbol: TAF2J)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TAF12 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated
Factor, 20kDa1 2
     TAFII202 3
TAF2J1 2 3     TAFII20/TAFII152 3
TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, J,
20kD1 2
     Transcription Initiation Factor TFIID Subunit 122
Transcription Initiation Factor TFIID 20/15 KDa Subunits2 3     TAF153
TAFII-20/TAFII-152 3     

External Ids:    HGNC: 115451   Entrez Gene: 68832   Ensembl: ENSG000001206567   OMIM: 6007735   UniProtKB: Q165143   

Export aliases for TAF12 gene to outside databases

Previous GC identifers: GC01P028822 GC01M027888 GC01M028434 GC01M028617 GC01M028750 GC01M028801 GC01M027182


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TAF12 Gene:
Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of
proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator
proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators
interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to
the basal transcription factors. Some of these associated factors are weakly attached while others are tightly
associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to
mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases.
TAF12 interacts directly with TBP as well as with TAF2I. Two transcript variants encoding the same protein have
been found for this gene. (provided by RefSeq, Sep 2008)

GeneCards Summary for TAF12 Gene:
TAF12 (TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa) is a protein-coding gene. GO annotations related to this gene include transcription factor binding and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: TAF12_HUMAN, Q16514
Function: TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and
TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase
transcription

Gene Wiki entry for TAF12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TAF12 gene promoter:
         TBP   Pbx1a   Tal-1   MyoD   Lmo2   POU6F1 (c2)   AP-4   CUTL1   E47   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAF12 promoter sequence
   Search Chromatin IP Primers for TAF12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TAF12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.3   Ensembl cytogenetic band:  1p35.3   HGNC cytogenetic band: 1p35

TAF12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAF12 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M028915:  view genomic region     (about GC identifiers)

Start:
28,915,835 bp from pter      End:
28,969,604 bp from pter
Size:
53,770 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TAF12_HUMAN, Q16514 (See protein sequence)
Recommended Name: Transcription initiation factor TFIID subunit 12  
Size: 161 amino acids; 17924 Da
Subunit: TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs).
TBP is not part of TFTC. Interacts directly with TBP; additional interactions between TAFII20 and TAFII28 or
TAFII30 were detected. Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3,
TAF5L/PAF65-beta, SUPT3H, TAF6L, TAF9, TAF10, TAF12 and TRRAP. Component of the STAGA transcription
coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, STAF65-gamma/KIAA0764, TADA3L, TAD1L,
TAF10, TAF12, TRRAP and TAF9. Interacts (isoform TAFII15 and isoform TAFII20) with ATF7 (via the transactivation
domain); the interaction is prevented by sumoylation of ATF7 and promotes (isoform TAFII20 only) the
transactivation of ATF7
1 PDB 3D structure from and Proteopedia for TAF12:
1H3O (3D)    
Secondary accessions: D3DPM5 Q15775 Q5T077
Alternative initiation: 2 isoforms:  Q16514-1   Q16514-2   

Explore the universe of human proteins at neXtProt for TAF12: NX_Q16514

Explore proteomics data for TAF12 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TAF12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001128690.1  NP_005635.1  

    ENSEMBL proteins: 
     ENSP00000362930   ENSP00000263974  
    Reactome Protein details: Q16514

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR003228 TFIID_sub
     IPR009072 Histone-fold

    Graphical View of Domain Structure for InterPro Entry Q16514

    ProtoNet protein and cluster: Q16514

    1 Blocks protein domain: IPB003228 Transcription initiation factor TFIID

    UniProtKB/Swiss-Prot: TAF12_HUMAN, Q16514
    Similarity: Belongs to the TAF12 family
    Similarity: Contains 1 histone-fold domain


    Find genes that share domains with TAF12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAF12_HUMAN, Q16514
    Function: TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and
    TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase
    transcription

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA15601843
    GO:0003700contributes to sequence-specific DNA binding transcription factor activity IDA9603525
    GO:0003713transcription coactivator activity IDA11564863
    GO:0004402contributes to histone acetyltransferase activity IDA11564863
    GO:0005515protein binding IPI11438666
         
    Find genes that share ontologies with TAF12           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TAF12:
     Decreased POU5F1-GFP protein e  Synthetic lethal with Ras 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TAF12

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    hsa-mir-92b-3p (MIRT040579)

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    hsa-miR-323-3p hsa-miR-4264 hsa-miR-3607-3p hsa-miR-520d-5p hsa-miR-429 hsa-miR-942 hsa-miR-200c hsa-miR-524-5p
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TAF12_HUMAN, Q16514: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    cytoskeleton1
    extracellular1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000125PCAF complex IDA9674425
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005669transcription factor TFIID complex IDA14580349

    Find genes that share ontologies with TAF12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TAF12 About   (see all 13)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Formation of RNA Pol II elongation complex
    RNA Polymerase II Pre-transcription Events0.73
    RNA Polymerase II HIV Promoter Escape0.67
    Transcription of the HIV genome0.71
    RNA Polymerase II Transcription Pre-Initiation And Promoter Opening0.67
    RNA Polymerase II Transcription Initiation And Promoter Clearance0.67
    RNA Polymerase II Transcription Initiation0.67
    RNA Polymerase II Promoter Escape0.67
    RNA Polymerase II Transcription0.60
    2Assembly of RNA Polymerase-II Initiation Complex
    Assembly of RNA Polymerase-II Initiation Complex0.91
    Basal transcription factors0.50
    Transcription of mRNA0.91
    Crosstalk Between CARM1 and ESRs0.39
    Protein Acetylation and Deacetylation0.51
    3HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    4RNA Polymerase I Promoter Opening
    Chromatin modifying enzymes0.34
    HATs acetylate histones0.34
    Chromatin organization0.34
    5Apoptotic Pathways in Synovial Fibroblasts
    Nuclear Receptor Activation by Vitamin-A0.57


    Find genes that share SuperPaths with TAF12           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for TAF12 (see all 7)
        Nuclear Receptor Activation by Vitamin-A
    Protein Acetylation and Deacetylation
    Assembly of RNA Polymerase-II Initiation Complex
    Glucocorticoid Receptor Signaling
    Estrogen Pathway

    1 GeneGo (Thomson Reuters) Pathway for TAF12
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    3 BioSystems Pathways for TAF12
        Eukaryotic Transcription Initiation
    C-MYC pathway
    Validated targets of C-MYC transcriptional activation


    Selected Reactome Pathways for TAF12 (see all 9)
        HATs acetylate histones
    RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
    RNA Polymerase II Transcription Initiation And Promoter Clearance
    RNA Polymerase II Promoter Escape
    RNA Polymerase II Transcription Initiation


    1 Kegg Pathway  (Kegg details for TAF12):
        Basal transcription factors

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TAF12
    Interactions:

        GeneGlobe Interaction Network for TAF12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TAF12 (Q165141, 2, 3 ENSP000002639744) via UniProtKB, MINT, STRING, and/or I2D (see all 761)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CPSF1Q105702, 3, ENSP000003393534MINT-7945693 I2D: score=3 STRING: ENSP00000339353
    EPS8L2Q9H6S32, 3MINT-7945693 I2D: score=4 
    TAF1CQ155721, 2, 3, ENSP000003678024EBI-1034238,EBI-2510659 MINT-4329031 MINT-4329049 I2D: score=2 STRING: ENSP00000367802
    TAF9Q165942, 3, ENSP000002178934MINT-7945693 I2D: score=3 STRING: ENSP00000370201 STRING: ENSP00000217893
    TBPP202261, 2, 3, ENSP000002303544EBI-1034238,EBI-355371 MINT-4329065 I2D: score=5 STRING: ENSP00000230354
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006325chromatin organization TAS--
    GO:0006352DNA-templated transcription, initiation IDA9603525
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--

    Find genes that share ontologies with TAF12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for TAF12



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TAF12 gene (2 alternative transcripts): 
    NM_001135218.1  NM_005644.3  

    Unigene Cluster for TAF12:

    TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
    Hs.530251  [show with all ESTs]
    Unigene Representative Sequence: BF217719
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000471683 ENST00000373824(uc001bqy.3 uc009vti.2) ENST00000263974(uc001bqx.3)
    ENST00000495422
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    Additional mRNA sequence: 

    AK310097.1 BC011986.1 BT007031.1 D50544.1 U57693.1 X84002.1 

    5 DOTS entries:

    DT.315898  DT.99988669  DT.91747947  DT.91747950  DT.91747956 

    Selected AceView cDNA sequences (see all 205):

    BM141667 CA430306 BX095156 H85093 AI264389 AI298511 AI653739 BU192210 
    CR590266 BQ019838 AW241433 BG388886 CA389592 BF590981 AI298813 AW513240 
    AI148451 AW001693 AW166605 CA309894 CF128243 CB046990 BI088190 BF797751 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TAF12    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b
    SP1:                    -     -     -                                                   
    SP2:                    -           -                                                   
    SP3:                          -     -                                                   
    SP4:                                                                                    


    ECgene alternative splicing isoforms for TAF12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TAF12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGATCCCAG
    TAF12 Expression
    About this image

    TAF12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TAF12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.530251

    UniProtKB/Swiss-Prot: TAF12_HUMAN, Q16514
    Tissue specificity: Ubiquitous

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TAF12 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Taf121 , 5 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated more1, 5 91.1(n)1
    96.27(a)1
      4 (65.09 cM)5
    664641  NM_025579.31  NP_079855.21 
     1322743755 
    chicken
    (Gallus gallus)
    Aves TAF121 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated more 84.06(n)
    95.03(a)
      419585  NM_001030894.2  NP_001026065.1 
    lizard
    (Anolis carolinensis)
    Reptilia TAF126
    TAF12 RNA polymerase II, TATA box binding protein ...
    92(a)
    1 ↔ 1
    GL344007.1(58141-66403)
    African clawed frog
    (Xenopus laevis)
    Amphibia taf12-A-prov2 TAF12 RNA polymerase II, TATA box binding protein 80.77(n)    D63522.1 
    zebrafish
    (Danio rerio)
    Actinopterygii taf122 TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated more 78.18(n)   386637  BC056696.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Taf121 TBP-associated factor 12 54.82(n)
    55.92(a)
      41406  NM_079596.3  NP_524320.1 
    worm
    (Caenorhabditis elegans)
    Secernentea taf-126
    Protein TAF-12, isoform a
    14(a)
    1 ↔ 1
    III(11862407-11869283) WBGene00006396
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TAF12(YDR145W)4 Subunit (61/68 kDa) of TFIID and SAGA complexes, involved more   --   4(746738-748357) 851723  NP_010429.1 


    ENSEMBL Gene Tree for TAF12 (if available)
    TreeFam Gene Tree for TAF12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TAF12 (see all 763)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1843535811,2
    --28929172(+) CAGGCA/GCCTGT 2 -- ds50010--------
    rs42529971,2
    C,F--28929257(-) cagtgA/Gtgtga 2 -- ds50011Minor allele frequency- G:0.01NS 176
    rs1145653661,2
    C,F--28929332(+) AAAAAC/ACAAAA 2 -- ds50011Minor allele frequency- A:0.02WA 118
    rs1881172631,2
    --28929554(+) GAGCTA/GCAATC 2 -- ds50010--------
    rs1435159831,2
    --28929571(+) TGCTTA/GTCCTG 2 -- ds50010--------
    rs1813211141,2
    --28929599(+) AAAGGC/TACCCT 2 -- ds50010--------
    rs42529961,2
    C,F--28929603(-) AAGACAG/-GGTAC 2 -- ds50011Minor allele frequency- -:0.01NS 178
    rs1379243371,2
    C--28929616(+) CGATTA/GATAAC 2 -- ut310--------
    rs1855807001,2
    --28929843(+) GAGATG/TGCAGG 2 -- ut310--------
    rs1907584951,2
    --28929869(+) GTTGGC/GGTAGG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for TAF12 (28915835 - 28969604 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TAF12:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660216CNV Deletion23128226
    esv2665007CNV Deletion23128226
    nsv506924CNV Insertion20534489
    nsv822209CNV Loss20364138
    nsv819244CNV Loss19587683

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TAF12
    DNA2.0 Custom Variant and Variant Library Synthesis for TAF12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600773    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for TAF12:
    Epidermodysplasia verruciformis

    Find genes that share disorders with TAF12           About GenesLikeMe


    Export disorders for TAF12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TAF12 gene, integrated from 10 sources (see all 62):
    (articles sorted by number of sources associating them with TAF12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID. (PubMed id 7729427)1, 2, 3 Mengus G....Davidson I. (EMBO J. 1995)
    2. A functional interaction between ATF7 and TAF12 that is modulated by TAF4. (PubMed id 15735663)1, 2, 9 Hamard P.J....Chatton B. (Oncogene 2005)
    3. The human TFIID components TAF(II)135 and TAF(II)20 and the yeast SAGA components ADA1 and TAF(II)68 heterodimerize to form histone-like pairs. (PubMed id 10594036)1, 2, 9 Gangloff Y.-G....Davidson I. (Mol. Cell. Biol. 2000)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage- binding factors in vivo. (PubMed id 11564863)1, 2 Martinez E.... Roeder R.G. (Mol. Cell. Biol. 2001)
    7. Histone-like TAFs within the PCAF histone acetylase complex. (PubMed id 9674425)1, 2 Ogryzko V.V.... Nakatani Y. (Cell 1998)
    8. The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily. (PubMed id 9885574)1, 2 Vassilev A.... Nakatani Y. (Mol. Cell 1998)
    9. Isolation and characterization of a cDNA encoding a novel human transcription factor TFIID subunit containing similarities with histones H2B and H3. (PubMed id 8647459)1, 2 Choi B.... Horikoshi M. (Gene 1996)
    10. A histone octamer-like structure within TFIID. (PubMed id 8598932)1, 2 Hoffmann A.... Roeder R.G. (Nature 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6883 HGNC: 11545 AceView: TAF12 Ensembl:ENSG00000120656 euGenes: HUgn6883
    ECgene: TAF12 Kegg: 6883 H-InvDB: TAF12

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TAF12 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/taf12/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TAF12 gene:
    Search GeneIP for patents involving TAF12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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