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Aliases for TAF12 Gene

Aliases for TAF12 Gene

  • TATA-Box Binding Protein Associated Factor 12 2 3 5
  • TAF12 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 20kDa 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, J, 20kD 2 3
  • Transcription Initiation Factor TFIID 20/15 KDa Subunits 3 4
  • TAFII-20/TAFII-15 3 4
  • TAFII20/TAFII15 3 4
  • TAFII20 3 4
  • TAF2J 3 4
  • Transcription Initiation Factor TFIID Subunit 12 3
  • TAF15 4

External Ids for TAF12 Gene

Previous HGNC Symbols for TAF12 Gene

  • TAF2J

Previous GeneCards Identifiers for TAF12 Gene

  • GC01P028822
  • GC01M027888
  • GC01M028434
  • GC01M028617
  • GC01M028750
  • GC01M028801
  • GC01M028915
  • GC01M027182
  • GC01M028622

Summaries for TAF12 Gene

Entrez Gene Summary for TAF12 Gene

  • Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2008]

GeneCards Summary for TAF12 Gene

TAF12 (TATA-Box Binding Protein Associated Factor 12) is a Protein Coding gene. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and protein heterodimerization activity.

UniProtKB/Swiss-Prot for TAF12 Gene

  • TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription.

Gene Wiki entry for TAF12 Gene

Additional gene information for TAF12 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF12 Gene

Genomics for TAF12 Gene

GeneHancer (GH) Regulatory Elements for TAF12 Gene

Promoters and enhancers for TAF12 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I028641 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.3 -301 3.3 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC LINC01715 TAF12 SRSF4 YTHDF2 GMEB1 SNORA73B SNHG12 SNHG3 TRNAU1AP PHACTR4
GH01I028516 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13.4 +124.3 124326 4.1 HDGF HNRNPUL1 PKNOX1 SMAD1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A RCC1 GMEB1 SRSF4 TRNAU1AP SNHG12 PHACTR4 YTHDF2 ENSG00000237934 ENSG00000231344 TAF12
GH01I028504 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13.4 +134.9 134900 6.6 CLOCK MLX YBX1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SNORA73B RCC1 SNORA73A SRSF4 GMEB1 TRNAU1AP SNHG12 PHACTR4 YTHDF2 SNHG3
GH01I028647 Promoter/Enhancer 1.7 Ensembl ENCODE 13.8 -5.3 -5336 2.7 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ENSG00000270103 GC01P028651 GC01P028669 GC01P028670 GC01P028671 GC01P028672 RNU11 SRSF4 GMEB1 TRNAU1AP
GH01I027866 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 13.3 +774.5 774469 3.3 HDGF HNRNPUL1 PKNOX1 ARNT IRF4 POLR2B ZNF766 ZNF143 ZNF592 SMARCA4 XKR8 GMEB1 WASF2 THEMIS2 TRNAU1AP EYA3 SNHG12 TAF12 RPA2 YTHDF2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TAF12 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TAF12 gene promoter:

Genomic Locations for TAF12 Gene

Genomic Locations for TAF12 Gene
chr1:28,589,323-28,643,109
(GRCh38/hg38)
Size:
53,787 bases
Orientation:
Minus strand
chr1:28,915,835-28,969,604
(GRCh37/hg19)

Genomic View for TAF12 Gene

Genes around TAF12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF12 Gene

Proteins for TAF12 Gene

  • Protein details for TAF12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16514-TAF12_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 12
    Protein Accession:
    Q16514
    Secondary Accessions:
    • D3DPM5
    • Q15775
    • Q5T077

    Protein attributes for TAF12 Gene

    Size:
    161 amino acids
    Molecular mass:
    17924 Da
    Quaternary structure:
    • TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC. Interacts directly with TBP; additional interactions between TAFII20 and TAFII28 or TAFII30 were detected. Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, TAF5L/PAF65-beta, SUPT3H, TAF6L, TAF9, TAF10, TAF12 and TRRAP. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, STAF65-gamma/KIAA0764, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. Interacts (isoform TAFII15 and isoform TAFII20) with ATF7 (via the transactivation domain); the interaction is prevented by sumoylation of ATF7 and promotes (isoform TAFII20 only) the transactivation of ATF7.

    Three dimensional structures from OCA and Proteopedia for TAF12 Gene

    Alternative splice isoforms for TAF12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAF12 Gene

Post-translational modifications for TAF12 Gene

No Post-translational modifications

Other Protein References for TAF12 Gene

No data available for DME Specific Peptides for TAF12 Gene

Domains & Families for TAF12 Gene

Gene Families for TAF12 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TAF12 Gene

Suggested Antigen Peptide Sequences for TAF12 Gene

Graphical View of Domain Structure for InterPro Entry

Q16514

UniProtKB/Swiss-Prot:

TAF12_HUMAN :
  • Belongs to the TAF12 family.
Family:
  • Belongs to the TAF12 family.
genes like me logo Genes that share domains with TAF12: view

Function for TAF12 Gene

Molecular function for TAF12 Gene

UniProtKB/Swiss-Prot Function:
TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription.

Gene Ontology (GO) - Molecular Function for TAF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001102 RNA polymerase II activating transcription factor binding IBA --
GO:0003677 DNA binding IEA,IDA 15601843
GO:0003700 contributes_to DNA binding transcription factor activity IDA 9603525
GO:0003713 transcription coactivator activity IDA 11564863
GO:0004402 contributes_to histone acetyltransferase activity IDA 11564863
genes like me logo Genes that share ontologies with TAF12: view
genes like me logo Genes that share phenotypes with TAF12: view

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAF12 Gene

Localization for TAF12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF12 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAF12 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TAF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000124 SAGA complex IBA --
GO:0005634 nucleus IDA,IEA 11564863
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex TAS,IDA 14580349
GO:0030914 STAGA complex IEA,IDA 11564863
genes like me logo Genes that share ontologies with TAF12: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TAF12 Gene

Pathways & Interactions for TAF12 Gene

genes like me logo Genes that share pathways with TAF12: view

Gene Ontology (GO) - Biological Process for TAF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006352 DNA-templated transcription, initiation IDA 9603525
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with TAF12: view

No data available for SIGNOR curated interactions for TAF12 Gene

Drugs & Compounds for TAF12 Gene

No Compound Related Data Available

Transcripts for TAF12 Gene

Unigene Clusters for TAF12 Gene

TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAF12 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - - -
SP2: - -
SP3: - -
SP4:

Relevant External Links for TAF12 Gene

GeneLoc Exon Structure for
TAF12
ECgene alternative splicing isoforms for
TAF12

Expression for TAF12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAF12 Gene

Protein differential expression in normal tissues from HIPED for TAF12 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (57.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TAF12 Gene



Protein tissue co-expression partners for TAF12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TAF12 Gene:

TAF12

SOURCE GeneReport for Unigene cluster for TAF12 Gene:

Hs.530251

mRNA Expression by UniProt/SwissProt for TAF12 Gene:

Q16514-TAF12_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for TAF12 Gene

  • Lung(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with TAF12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAF12 Gene

Orthologs for TAF12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAF12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF12 33 34
  • 99.38 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 99 (a)
OneToMany
TAF12 33
  • 96.48 (n)
-- 34
  • 76 (a)
OneToMany
-- 34
  • 50 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TAF12 33 34
  • 95.24 (n)
-- 34
  • 91 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TAF12 34
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Taf12 33
  • 91.72 (n)
mouse
(Mus musculus)
Mammalia Taf12 33 16 34
  • 91.1 (n)
oppossum
(Monodelphis domestica)
Mammalia TAF12 34
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAF12 33 34
  • 84.06 (n)
lizard
(Anolis carolinensis)
Reptilia TAF12 34
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia taf12 33
  • 73.5 (n)
Str.7323 33
African clawed frog
(Xenopus laevis)
Amphibia taf12-A-prov 33
zebrafish
(Danio rerio)
Actinopterygii taf12 33 34
  • 73.79 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003135 33
  • 64.06 (n)
fruit fly
(Drosophila melanogaster)
Insecta Taf12 33 34
  • 54.82 (n)
worm
(Caenorhabditis elegans)
Secernentea taf-12 34
  • 14 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF12 34 36
  • 12 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4626 34
  • 36 (a)
OneToOne
Species where no ortholog for TAF12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAF12 Gene

ENSEMBL:
Gene Tree for TAF12 (if available)
TreeFam:
Gene Tree for TAF12 (if available)

Paralogs for TAF12 Gene

No data available for Paralogs for TAF12 Gene

Variants for TAF12 Gene

Sequence variations from dbSNP and Humsavar for TAF12 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000005309 -- 28,624,736(-) G/A intron_variant
rs1000048806 -- 28,631,049(-) A/G intron_variant
rs1000054016 -- 28,630,870(-) C/T intron_variant
rs1000247583 -- 28,613,987(-) C/G intron_variant
rs1000371673 -- 28,647,701(-) C/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TAF12 Gene

Variant ID Type Subtype PubMed ID
esv2660216 CNV deletion 23128226
esv2665007 CNV deletion 23128226
esv3585589 CNV loss 21293372
nsv475854 CNV novel sequence insertion 20440878
nsv476520 CNV novel sequence insertion 20440878
nsv506924 OTHER sequence alteration 20534489
nsv545916 CNV gain 21841781
nsv819244 CNV loss 19587683
nsv822209 CNV loss 20364138

Variation tolerance for TAF12 Gene

Residual Variation Intolerance Score: 64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 4.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TAF12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAF12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF12 Gene

Disorders for TAF12 Gene

Additional Disease Information for TAF12

No disorders were found for TAF12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAF12 Gene

Publications for TAF12 Gene

  1. A functional interaction between ATF7 and TAF12 that is modulated by TAF4. (PMID: 15735663) Hamard PJ … Chatton B (Oncogene 2005) 3 4 22 58
  2. The human TFIID components TAF(II)135 and TAF(II)20 and the yeast SAGA components ADA1 and TAF(II)68 heterodimerize to form histone-like pairs. (PMID: 10594036) Gangloff YG … Davidson I (Molecular and cellular biology 2000) 3 4 22 58
  3. Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID. (PMID: 7729427) Mengus G … Davidson I (The EMBO journal 1995) 2 3 4 58
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for TAF12 Gene

Sources for TAF12 Gene

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