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Aliases for TAF12 Gene

Aliases for TAF12 Gene

  • TATA-Box Binding Protein Associated Factor 12 2 3 5
  • TAF12 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 20kDa 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, J, 20kD 2 3
  • Transcription Initiation Factor TFIID 20/15 KDa Subunits 3 4
  • TAFII-20/TAFII-15 3 4
  • TAFII20/TAFII15 3 4
  • TAFII20 3 4
  • TAF2J 3 4
  • TATA Box Binding Protein Associated Factor 12 3
  • TAF15 4

External Ids for TAF12 Gene

Previous HGNC Symbols for TAF12 Gene

  • TAF2J

Previous GeneCards Identifiers for TAF12 Gene

  • GC01P028822
  • GC01M027888
  • GC01M028434
  • GC01M028750
  • GC01M028801
  • GC01M028915
  • GC01M027182

Summaries for TAF12 Gene

Entrez Gene Summary for TAF12 Gene

  • Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2008]

GeneCards Summary for TAF12 Gene

TAF12 (TATA-Box Binding Protein Associated Factor 12) is a Protein Coding gene. Among its related pathways are Chromatin organization and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein heterodimerization activity.

UniProtKB/Swiss-Prot for TAF12 Gene

  • TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription.

Gene Wiki entry for TAF12 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF12 Gene

Genomics for TAF12 Gene

Regulatory Elements for TAF12 Gene

Enhancers for TAF12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TAF12 on UCSC Golden Path with GeneCards custom track

Promoters for TAF12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TAF12 on UCSC Golden Path with GeneCards custom track

Genomic Location for TAF12 Gene

Chromosome:
1
Start:
28,589,323 bp from pter
End:
28,643,109 bp from pter
Size:
53,787 bases
Orientation:
Minus strand

Genomic View for TAF12 Gene

Genes around TAF12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF12 Gene

Proteins for TAF12 Gene

  • Protein details for TAF12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16514-TAF12_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 12
    Protein Accession:
    Q16514
    Secondary Accessions:
    • D3DPM5
    • Q15775
    • Q5T077

    Protein attributes for TAF12 Gene

    Size:
    161 amino acids
    Molecular mass:
    17924 Da
    Quaternary structure:
    • TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC. Interacts directly with TBP; additional interactions between TAFII20 and TAFII28 or TAFII30 were detected. Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, TAF5L/PAF65-beta, SUPT3H, TAF6L, TAF9, TAF10, TAF12 and TRRAP. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, STAF65-gamma/KIAA0764, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. Interacts (isoform TAFII15 and isoform TAFII20) with ATF7 (via the transactivation domain); the interaction is prevented by sumoylation of ATF7 and promotes (isoform TAFII20 only) the transactivation of ATF7.

    Three dimensional structures from OCA and Proteopedia for TAF12 Gene

    Alternative splice isoforms for TAF12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAF12 Gene

Proteomics data for TAF12 Gene at MOPED

Post-translational modifications for TAF12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAF12 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for TAF12

No data available for DME Specific Peptides for TAF12 Gene

Domains & Families for TAF12 Gene

Gene Families for TAF12 Gene

Protein Domains for TAF12 Gene

Suggested Antigen Peptide Sequences for TAF12 Gene

Graphical View of Domain Structure for InterPro Entry

Q16514

UniProtKB/Swiss-Prot:

TAF12_HUMAN :
  • Contains 1 histone-fold domain.
  • Belongs to the TAF12 family.
Domain:
  • Contains 1 histone-fold domain.
Family:
  • Belongs to the TAF12 family.
genes like me logo Genes that share domains with TAF12: view

Function for TAF12 Gene

Molecular function for TAF12 Gene

UniProtKB/Swiss-Prot Function:
TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription.

Gene Ontology (GO) - Molecular Function for TAF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 7667268
genes like me logo Genes that share ontologies with TAF12: view
genes like me logo Genes that share phenotypes with TAF12: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAF12 Gene

Localization for TAF12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAF12 Gene COMPARTMENTS Subcellular localization image for TAF12 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TAF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with TAF12: view

Pathways & Interactions for TAF12 Gene

genes like me logo Genes that share pathways with TAF12: view

Gene Ontology (GO) - Biological Process for TAF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0016032 viral process TAS --
GO:0043966 histone H3 acetylation IDA 11564863
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity IDA 15735663
GO:1901796 regulation of signal transduction by p53 class mediator TAS --
genes like me logo Genes that share ontologies with TAF12: view

No data available for SIGNOR curated interactions for TAF12 Gene

Drugs & Compounds for TAF12 Gene

No Compound Related Data Available

Transcripts for TAF12 Gene

Unigene Clusters for TAF12 Gene

TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAF12 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - - -
SP2: - -
SP3: - -
SP4:

Relevant External Links for TAF12 Gene

GeneLoc Exon Structure for
TAF12
ECgene alternative splicing isoforms for
TAF12

Expression for TAF12 Gene

mRNA expression in normal human tissues for TAF12 Gene

Protein differential expression in normal tissues from HIPED for TAF12 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (57.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TAF12 Gene



SOURCE GeneReport for Unigene cluster for TAF12 Gene Hs.530251

mRNA Expression by UniProt/SwissProt for TAF12 Gene

Q16514-TAF12_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with TAF12: view

Protein tissue co-expression partners for TAF12 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TAF12 Gene

Orthologs for TAF12 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAF12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TAF12 35
  • 95.24 (n)
  • 99.38 (a)
-- 36
  • 91 (a)
OneToMany
TAF12 36
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TAF12 35
  • 96.48 (n)
  • 98.76 (a)
-- 36
  • 76 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Taf12 35
  • 91.1 (n)
  • 96.27 (a)
Taf12 16
Taf12 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TAF12 35
  • 99.38 (n)
  • 98.76 (a)
TAF12 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Taf12 35
  • 91.72 (n)
  • 96.89 (a)
oppossum
(Monodelphis domestica)
Mammalia TAF12 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TAF12 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves TAF12 35
  • 84.06 (n)
  • 95.03 (a)
TAF12 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAF12 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.7323 35
taf12 35
  • 73.5 (n)
  • 81.37 (a)
African clawed frog
(Xenopus laevis)
Amphibia taf12-A-prov 35
zebrafish
(Danio rerio)
Actinopterygii taf12 35
  • 73.79 (n)
  • 84.28 (a)
taf12 36
  • 80 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003135 35
  • 64.06 (n)
  • 70.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta Taf12 35
  • 54.82 (n)
  • 55.92 (a)
Taf12 36
  • 41 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea taf-12 36
  • 14 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF12 36
  • 12 (a)
OneToOne
TAF12 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4626 36
  • 36 (a)
OneToOne
Species with no ortholog for TAF12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAF12 Gene

ENSEMBL:
Gene Tree for TAF12 (if available)
TreeFam:
Gene Tree for TAF12 (if available)

Paralogs for TAF12 Gene

No data available for Paralogs for TAF12 Gene

Variants for TAF12 Gene

Sequence variations from dbSNP and Humsavar for TAF12 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1804642 -- 28,621,989(-) TCCAT(C/G)GCCAA reference, missense
rs3795844 -- 28,605,259(-) GCAAA(C/T)TTCAC intron-variant
rs3795845 -- 28,605,113(-) TGTTG(A/C)TTCTG intron-variant
rs2995157 -- 28,611,559(+) agaga(C/G)acaga intron-variant
rs2995158 -- 28,635,827(-) TTTTT(A/T)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAF12 Gene

Variant ID Type Subtype PubMed ID
nsv506924 CNV Insertion 20534489
nsv819244 CNV Loss 19587683
nsv822209 CNV Loss 20364138
esv2660216 CNV Deletion 23128226
esv2665007 CNV Deletion 23128226

Variation tolerance for TAF12 Gene

Residual Variation Intolerance Score: 64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.22; 4.98% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TAF12 Gene

Disorders for TAF12 Gene

Relevant External Links for TAF12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAF12

No disorders were found for TAF12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAF12 Gene

Publications for TAF12 Gene

  1. Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID. (PMID: 7729427) Mengus G. … Davidson I. (EMBO J. 1995) 2 3 4 67
  2. A functional interaction between ATF7 and TAF12 that is modulated by TAF4. (PMID: 15735663) Hamard P.J. … Chatton B. (Oncogene 2005) 3 23
  3. The human TFIID components TAF(II)135 and TAF(II)20 and the yeast SAGA components ADA1 and TAF(II)68 heterodimerize to form histone-like pairs. (PMID: 10594036) Gangloff Y.-G. … Davidson I. (Mol. Cell. Biol. 2000) 3 23
  4. Evolutionary conservation of human TATA-binding-polypeptide- associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors. (PMID: 7667268) Hisatake K. … Roeder R.G. (Proc. Natl. Acad. Sci. U.S.A. 1995) 3 23
  5. Cross-Species Genomics Identifies TAF12, NFYC, and RAD54L as Choroid Plexus Carcinoma Oncogenes. (PMID: 25965574) Tong Y. … Gilbertson R.J. (Cancer Cell 2015) 3

Products for TAF12 Gene

Sources for TAF12 Gene

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