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Aliases for TAF11 Gene

Aliases for TAF11 Gene

  • TAF11 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 28kDa 2 3
  • TAFII28 3 4 6
  • TAF2I 3 4 6
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, I, 28kD 2 3
  • Transcription Initiation Factor TFIID 28 KDa Subunit 3 4
  • TFIID Subunit P30-Beta 3 4
  • TAF(II)28 3 4
  • TAFII-28 3 4
  • Transcription Initiation Factor TFIID 28 KD Subunit 3
  • Transcription Initiation Factor TFIID Subunit 11 3
  • MGC:15243 3
  • PRO2134 3

External Ids for TAF11 Gene

Previous HGNC Symbols for TAF11 Gene

  • TAF2I

Previous GeneCards Identifiers for TAF11 Gene

  • GC06M034847
  • GC06M034892
  • GC06M034953
  • GC06M034568
  • GC06M034974
  • GC06M035239
  • GC06M035734

Summaries for TAF11 Gene

Entrez Gene Summary for TAF11 Gene

  • Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit of TFIID that is present in all TFIID complexes and interacts with TBP. This subunit also interacts with another small subunit, TAF13, to form a heterodimer with a structure similar to the histone core structure. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for TAF11 Gene

TAF11 (TAF11 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 28kDa) is a Protein Coding gene. Among its related pathways are Disease and GPCR Pathway. GO annotations related to this gene include protein heterodimerization activity and protein N-terminus binding.

UniProtKB/Swiss-Prot for TAF11 Gene

  • Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively)

Gene Wiki entry for TAF11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF11 Gene

Genomics for TAF11 Gene

Regulatory Elements for TAF11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TAF11 Gene

Start:
34,877,778 bp from pter
End:
34,888,089 bp from pter
Size:
10,312 bases
Orientation:
Minus strand

Genomic View for TAF11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF11 Gene

Proteins for TAF11 Gene

  • Protein details for TAF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15544-TAF11_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 11
    Protein Accession:
    Q15544
    Secondary Accessions:
    • B2R8R3
    • B4DY18
    • Q9UHS0

    Protein attributes for TAF11 Gene

    Size:
    211 amino acids
    Molecular mass:
    23307 Da
    Quaternary structure:
    • TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts with TAF13 both in vitro and intracellularly; also interacts directly with TBP.
    SequenceCaution:
    • Sequence=AAF22038.1; Type=Frameshift; Positions=208; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TAF11 Gene

    Alternative splice isoforms for TAF11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAF11 Gene

Proteomics data for TAF11 Gene at MOPED

Post-translational modifications for TAF11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAF11 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TAF11 Gene

Domains for TAF11 Gene

Protein Domains for TAF11 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q15544

UniProtKB/Swiss-Prot:

TAF11_HUMAN :
  • Q15544
Domain:
  • TBP and TAFII18 bind to distinct domains of TAFII28
Family:
  • Belongs to the TAF11 family.
genes like me logo Genes that share domains with TAF11: view

No data available for Gene Families for TAF11 Gene

Function for TAF11 Gene

Molecular function for TAF11 Gene

UniProtKB/Swiss-Prot Function: Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively)

Gene Ontology (GO) - Molecular Function for TAF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003713 transcription coactivator activity IDA 8670810
GO:0005515 protein binding IPI 25416956
GO:0042809 vitamin D receptor binding IPI 10744685
GO:0043565 sequence-specific DNA binding --
genes like me logo Genes that share ontologies with TAF11: view

Phenotypes for TAF11 Gene

GenomeRNAi human phenotypes for TAF11:
genes like me logo Genes that share phenotypes with TAF11: view

Animal Model Products

miRNA for TAF11 Gene

miRTarBase miRNAs that target TAF11

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TAF11 Gene

Localization for TAF11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAF11 Gene COMPARTMENTS Subcellular localization image for TAF11 gene
Compartment Confidence
nucleus 5
cytosol 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TAF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex IDA 14580349
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with TAF11: view

Pathways for TAF11 Gene

genes like me logo Genes that share pathways with TAF11: view

Gene Ontology (GO) - Biological Process for TAF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with TAF11: view

Transcripts for TAF11 Gene

mRNA/cDNA for TAF11 Gene

Unigene Clusters for TAF11 Gene

TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TAF11

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAF11 Gene

No ASD Table

Relevant External Links for TAF11 Gene

GeneLoc Exon Structure for
TAF11
ECgene alternative splicing isoforms for
TAF11

Expression for TAF11 Gene

mRNA expression in normal human tissues for TAF11 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAF11 Gene

SOURCE GeneReport for Unigene cluster for TAF11 Gene Hs.112444

genes like me logo Genes that share expressions with TAF11: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TAF11 Gene

Orthologs for TAF11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAF11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF11 35
  • 99.68 (n)
  • 99.05 (a)
TAF11 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAF11 35
  • 89.37 (n)
  • 91.9 (a)
TAF11 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAF11 35
  • 89.73 (n)
  • 90.05 (a)
TAF11 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taf11 35
  • 84.68 (n)
  • 86.73 (a)
Taf11 16
Taf11 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 75 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
-- 36
  • 71 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TAF11 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Taf11 35
  • 84.04 (n)
  • 86.26 (a)
chicken
(Gallus gallus)
Aves TAF11 35
  • 69.6 (n)
  • 73.06 (a)
TAF11 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TAF11 36
  • 83 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8264 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1018 35
taf11 35
  • 74.4 (n)
  • 84.06 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5100 35
zebrafish
(Danio rerio)
Actinopterygii Dr.15759 35
taf11 35
  • 74.88 (n)
  • 83.33 (a)
taf11 36
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Taf11 35
  • 63.44 (n)
  • 67.74 (a)
Taf11 36
  • 48 (a)
OneToOne
Taf11 37
  • 71 (a)
worm
(Caenorhabditis elegans)
Secernentea taf-11.1 36
  • 23 (a)
OneToMany
taf-11.2 36
  • 19 (a)
OneToMany
taf-11.3 36
  • 22 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF11 36
  • 12 (a)
OneToOne
TAF11 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2026 35
Species with no ortholog for TAF11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAF11 Gene

ENSEMBL:
Gene Tree for TAF11 (if available)
TreeFam:
Gene Tree for TAF11 (if available)

Paralogs for TAF11 Gene

genes like me logo Genes that share paralogs with TAF11: view

No data available for Paralogs for TAF11 Gene

Variants for TAF11 Gene

Sequence variations from dbSNP and Humsavar for TAF11 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs15922 - 34,883,049(+) AACAA(C/G)AGTTG reference, missense
rs2273006 -- 34,883,357(+) TGCCA(C/T)GGATC intron-variant
rs3215537 -- 34,883,381(+) CCCCC(-/T)GGGCC intron-variant
rs4646917 -- 34,886,757(-) tgggc(C/G)tagtg intron-variant
rs4646918 -- 34,886,243(-) tggca(-/CA)gtctc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAF11 Gene

Variant ID Type Subtype PubMed ID
dgv6831n71 CNV Gain 21882294
nsv462905 CNV Gain 19166990
nsv885797 CNV Gain 21882294
nsv508402 CNV Loss 20534489

Relevant External Links for TAF11 Gene

HapMap Linkage Disequilibrium report
TAF11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF11 Gene

Disorders for TAF11 Gene

(2) University of Copenhagen DISEASES for TAF11 Gene

Relevant External Links for TAF11

Genetic Association Database (GAD)
TAF11
Human Genome Epidemiology (HuGE) Navigator
TAF11
genes like me logo Genes that share disorders with TAF11: view

No data available for UniProtKB/Swiss-Prot for TAF11 Gene

Publications for TAF11 Gene

  1. Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID. (PMID: 7729427) Mengus G. … Davidson I. (EMBO J. 1995) 2 3 4
  2. Isolation and characterization of a cDNA encoding a human TFIID subunit containing a variety of putative structural motifs including direct repeats. (PMID: 8820923) Kuzuhara T. … Horikoshi M. (Biol. Pharm. Bull. 1996) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family. (PMID: 9695952) Birck C. … Moras D. (Cell 1998) 3 4
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4

Products for TAF11 Gene

Sources for TAF11 Gene

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