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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAF11 Gene

protein-coding   GIFtS: 61
GCID: GC06M035239

TAF11 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated...

(Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase...)
(Previous symbol: TAF2I)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
TAF11 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated
Factor, 28kDa1 2
     TAFII-282 3
TAF2I1 2 3 5     TFIID Subunit P30-Beta2 3
TAFII282 3 5     MGC:152432
TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, I,
28kD1 2
     Transcription Initiation Factor TFIID 28 KD Subunit2
Transcription Initiation Factor TFIID 28 KDa Subunit2 3     Transcription Initiation Factor TFIID Subunit 112
TAF(II)282 3     

External Ids:    HGNC: 115441   Entrez Gene: 68822   Ensembl: ENSG000000649957   OMIM: 6007725   UniProtKB: Q155443   

Export aliases for TAF11 gene to outside databases

Previous GC identifers: GC06M034847 GC06M034892 GC06M034953 GC06M034568 GC06M034974


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TAF11 Gene:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein
that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to
position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription
complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a
group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal
transcription, serve as coactivators, function in promoter recognition or modify general transcription factors
(GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit of TFIID
that is present in all TFIID complexes and interacts with TBP. This subunit also interacts with another small
subunit, TAF13, to form a heterodimer with a structure similar to the histone core structure. Two transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2012)

GeneCards Summary for TAF11 Gene: 
TAF11 (TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa) is a protein-coding gene. Diseases associated with TAF11 include epidermodysplasia verruciformis, and facioscapulohumeral muscular dystrophy, and among its related super-pathways are Assembly of RNA Polymerase-II Initiation Complex and RNA Polymerase II Pre-transcription Events. GO annotations related to this gene include protein heterodimerization activity and protein N-terminus binding.

UniProtKB/Swiss-Prot: TAF11_HUMAN, Q15544
Function: Core TAFII present in both of the previously described TFIID species which either lack or contain
TAFII30 (TFIID alpha and TFIID beta respectively)

Gene Wiki entry for TAF11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAF11 gene promoter:
         AML1a   POU3F1   AP-4   LCR-F1   HEN1   CREB   deltaCREB   HOXA5   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTAF11 promoter sequence
   Search SABiosciences Chromatin IP Primers for TAF11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAF11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.31   Ensembl cytogenetic band:  6p21.31   HGNC cytogenetic band: 6p21

TAF11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAF11 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M035239:  view genomic region     (about GC identifiers)

Start:
34,845,555 bp from pter      End:
34,855,866 bp from pter
Size:
10,312 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TAF11_HUMAN, Q15544 (See protein sequence)
Recommended Name: Transcription initiation factor TFIID subunit 11  
Size: 211 amino acids; 23307 Da
Subunit: TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts
with TAF13 both in vitro and intracellularly; also interacts directly with TBP
Subcellular location: Nucleus
Sequence caution: Sequence=AAF22038.1; Type=Frameshift; Positions=208;
2 PDB 3D structures from and Proteopedia for TAF11:
1BH8 (3D)        1BH9 (3D)    
Secondary accessions: B2R8R3 B4DY18 Q9UHS0
Alternative splicing: 2 isoforms:  Q15544-1   Q15544-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TAF11: NX_Q15544

Explore proteomics data for TAF11 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15544

  • TAF11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TAF11 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001257417.1  NP_005634.1  

    ENSEMBL proteins: 
     ENSP00000354633   ENSP00000408121  
    Reactome Protein details: Q15544
    Human Recombinant Protein Products for TAF11: 
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    Cloud-Clone Corp. Proteins for TAF11 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005669transcription factor TFIID complex IDA14580349

    TAF11 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR006809 TAFII28
     IPR009072 Histone-fold

    Graphical View of Domain Structure for InterPro Entry Q15544

    ProtoNet protein and cluster: Q15544

    1 Blocks protein domain: IPB006809 TAFII28-like protein

    UniProtKB/Swiss-Prot: TAF11_HUMAN, Q15544
    Domain: TBP and TAFII18 bind to distinct domains of TAFII28
    Similarity: Belongs to the TAF11 family


    TAF11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAF11_HUMAN, Q15544
    Function: Core TAFII present in both of the previously described TFIID species which either lack or contain
    TAFII30 (TFIID alpha and TFIID beta respectively)

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003713transcription coactivator activity IDA8670810
    GO:0005515protein binding IPI7729427
    GO:0042809vitamin D receptor binding IPI10744685
    GO:0043565sequence-specific DNA binding ----
         
    TAF11 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TAF11:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TAF11 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TAF11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TAF11 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TAF11 

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    SwitchGear 3'UTR luciferase reporter plasmidTAF11 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TAF11 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Assembly of RNA Polymerase-II Initiation Complex
    Assembly of RNA Polymerase-II Initiation Complex0.91
    Basal transcription factors0.50
    Transcription of mRNA0.91
    Crosstalk Between CARM1 and ESRs0.39
    Protein Acetylation and Deacetylation0.51
    2Formation of RNA Pol II elongation complex
    RNA Polymerase II Pre-transcription Events0.72
    RNA Polymerase II HIV Promoter Escape0.67
    Transcription of the HIV genome0.70
    RNA Polymerase II Transcription Pre-Initiation And Promoter Opening0.67
    RNA Polymerase II Transcription Initiation And Promoter Clearance0.67
    HIV Transcription Initiation0.67
    RNA Polymerase II Promoter Escape0.67
    RNA Polymerase II Transcription Initiation0.67
    3HIV Life Cycle
    HIV Life Cycle0.92
    HIV Infection0.61
    Late Phase of HIV Life Cycle0.92
    4Transcription
    Transcription0.69
    RNA Polymerase II Transcription0.69
    5Apoptotic Pathways in Synovial Fibroblasts
    Nuclear Receptor Activation by Vitamin-A0.57

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for TAF11
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TAF11 (see all 7)
        Nuclear Receptor Activation by Vitamin-A
    Protein Acetylation and Deacetylation
    Assembly of RNA Polymerase-II Initiation Complex
    Glucocorticoid Receptor Signaling
    Estrogen Pathway

    1 GeneGo (Thomson Reuters) Pathway for TAF11
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    5/15        Reactome Pathways for TAF11 (see all 15)
        RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
    Late Phase of HIV Life Cycle
    RNA Polymerase II Transcription
    Transcription
    RNA Polymerase II Transcription Initiation And Promoter Clearance


    1         Kegg Pathway  (Kegg details for TAF11):
        Basal transcription factors


    TAF11 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TAF11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/62 Interacting proteins for TAF11 (Q155441, 2, 3 ENSP000003546334) via UniProtKB, MINT, STRING, and/or I2D (see all 62)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RXRBP287023, ENSP000003638124I2D: score=1 STRING: ENSP00000363812
    ENSG00000206289P287023I2D: score=1 
    ENSG00000227322P287023I2D: score=1 
    ENSG00000228333P287023I2D: score=1 
    ENSG00000231321P287023I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--

    TAF11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TAF11

    Search CenterWatch for drugs/clinical trials and news about TAF11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TAF11 gene (2 alternative transcripts): 
    NM_001270488.1  NM_005643.3  

    Unigene Cluster for TAF11:

    TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa
    Hs.112444  [show with all ESTs]
    Unigene Representative Sequence: BX647568
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361288(uc003ojw.1 uc011dsr.1) ENST00000420584
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/10 QIAGEN miScript miRNA Assays for microRNAs that regulate TAF11 (see all 10):
    hsa-miR-198 hsa-miR-29a hsa-miR-29c hsa-miR-548aa hsa-miR-500a hsa-miR-146a* hsa-miR-891b hsa-miR-362-5p
    SwitchGear 3'UTR luciferase reporter plasmidTAF11 3' UTR sequence
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    Additional mRNA sequence: 

    AF118094.1 AK096675.1 AK302226.1 AK313475.1 BC021972.2 BT019404.1 BT019405.1 BX538195.1 
    BX647568.1 CR542068.1 D63705.1 X83928.1 

    10 DOTS entries:

    DT.447280  DT.95131854  DT.40292765  DT.100710244  DT.95173358  DT.95173349  DT.70105086  DT.102825292 
    DT.100719195  DT.97844283 

    24/214 AceView cDNA sequences (see all 214):

    BX337015 BQ773979 AU135297 BU196654 BE797026 AA563801 BQ775406 AA629347 
    BC021972 AW574835 CD366593 BQ894217 BM786534 AI216409 AI080744 W02134 
    BQ669925 BX647568 CR542068 CB120437 BM800533 BM424110 AI139931 BQ058942 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TAF11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TAF11 Expression
    About this image


    See TAF11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TAF11

    SOURCE GeneReport for Unigene cluster: Hs.112444
        SABiosciences Custom PCR Arrays for TAF11
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TAF11 gene from 10/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Taf111 , 5 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated more1, 5 84.68(n)1
    86.73(a)1
      17 (14.60 cM)5
    687761  NM_026836.21  NP_081112.11 
     279011225 
    chicken
    (Gallus gallus)
    Aves TAF111 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated more 71.48(n)
    75.26(a)
      419899  NM_001244905.1  NP_001231834.1 
    lizard
    (Anolis carolinensis)
    Reptilia TAF116
    Uncharacterized protein
    83(a)
    1 ↔ 1
    4(121060802-121063115)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.82642 Xenopus laevis transcribed sequence with weak similarity more 78.45(n)    48030816 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.157592 Transcribed sequence with weak similarity to protein more 75.28(n)    CF997797.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Taf111 , 3 transcription initiation from Pol II
    promoter more3
    TBP-associated factor 111
    71(a)3
    59.47(n)1
    61.11(a)1
      30C73
    342931  NM_164871.21  NP_723484.11 
    worm
    (Caenorhabditis elegans)
    Secernentea taf-11.21 Protein TAF-11.2 51.65(n)
    41.98(a)
      172451  NM_059618.3  NP_492019.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TAF11(YML015C)4 TFIID subunit (40 kDa), involved in RNA polymerase more   --   13(243029-241989) 854993  NP_013697.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TAF111 transcription initiation factor TFIID subunit D9 52.34(n)
    39.06(a)
      827775  NM_118147.4  NP_193761.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g06804001 hypothetical protein 46.81(n)
    36.7(a)
      4325286  NM_001050407.1  NP_001043872.2 


    ENSEMBL Gene Tree for TAF11 (if available)
    TreeFam Gene Tree for TAF11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TAF11 gene

    TAF11 for paralogs           About GeneDecksing


    5/20 Pseudogenes.org Pseudogenes for TAF11 (see all 20)
    PGOHUM00000251287 PGOHUM00000251288 PGOHUM00000251289 PGOHUM00000251290 PGOHUM00000251291


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/216 SNPs in TAF11 are shown (see all 216)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1158149801,2
    F--34845911(+) GTAGTC/TCTAGC 2 -- ut311Minor allele frequency- T:0.01WA 118
    rs1895500361,2
    --34846030(+) AACGAA/GACCAA 2 -- ut310--------
    rs46469481,2
    C,F--34846044(-) AgtttT/Cgtttt 2 -- ut314Minor allele frequency- C:0.01NS NA 314
    rs1497748431,2
    --34846052(+) ACTCTC/GTTGGA 2 -- ut310--------
    rs1817701581,2
    --34846150(+) CTTCAA/GAATGC 2 -- ut310--------
    rs1838265381,2
    --34846183(+) TCAAGC/GCAAGT 2 -- ut310--------
    rs46469471,2
    C,F,H--34846277(-) GTATCT/CCAGGC 2 -- ut31 ese321Minor allele frequency- C:0.03NS EA NA 2220
    rs46469461,2
    C--34846291(-) GCATTG/AGTGCT 2 -- ut312Minor allele frequency- A:0.01NS NA 180
    rs1896115451,2
    --34846308(+) TCTTAC/TAGGAA 2 -- ut310--------
    rs1457320471,2
    C--34846323(+) GGAACC/TAATAC 2 -- ut310--------

    HapMap Linkage Disequilibrium report for TAF11 (34845555 - 34855866 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TAF11:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508402CNV Loss20534489
    nsv885797CNV Gain21882294
    nsv462905CNV Gain19166990
    dgv6831n71CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600772    OMIM disorders: --

    6 diseases for TAF11:    About MalaCards
    epidermodysplasia verruciformis    facioscapulohumeral muscular dystrophy    muscular dystrophy    t-cell leukemia
    thyroiditis    leukemia

    2 diseases from the University of Copenhagen DISEASES database for TAF11:
    Facioscapulohumeral muscular dystrophy     Epidermodysplasia verruciformis

    TAF11 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TAF11
    Human Genome Epidemiology (HuGE) Navigator: TAF11 (1 document)

    Export disorders for TAF11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TAF11 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with TAF11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a cDNA encoding a human TFIID subunit containing a variety of putative structural motifs including direct repeats. (PubMed id 8820923)1, 2, 3 Kuzuhara T. and Horikoshi M. (1996)
    2. Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID. (PubMed id 7729427)1, 2, 3 Mengus G....Davidson I. (1995)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family. (PubMed id 9695952)1, 2 Birck C.... Moras D. (1998)
    6. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resi stance. (PubMed id 22581228)1 Manning A.K....Langenberg C. (2012)
    7. Human mediator subunit MED26 functions as a docking s ite for transcription elongation factors. (PubMed id 21729782)1 Takahashi H....Conaway J.W. (2011)
    8. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    9. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (2010)
    10. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6882 HGNC: 11544 AceView: TAF11 Ensembl:ENSG00000064995 euGenes: HUgn6882
    ECgene: TAF11 Kegg: 6882 H-InvDB: TAF11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TAF11 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/taf11/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TAF11 gene:
    Search GeneIP for patents involving TAF11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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