TAF11 Gene
protein-coding GIFtS : 62
GC06M034953
TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa (Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase II, I, 28kD )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbol: TAF2I )
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Aliases & Descriptions for TAF11
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases MGC:15243 2 OTTHUMP00000016241 2 PRO2134 2 TAF(II)28 3 TAF2I 2 , 3 , 5 TAFII-28 3 TAFII28 1 , 2 , 3 , 5
Descriptions TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28 kD 2 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa 2 TAF11 RNA polymerase II, TATA box binding protein-associated factor, 28kDa 1 TATA box binding protein (TBP)-associated factor, RNA polymerase II, I, 28kD 1 , 2 TBP-associated factor 11 2 TFIID subunit p30-beta 2 , 3 Transcription initiation factor TFIID 28 kDa subunit 3 transcription initiation factor TFIID 28 kD subunit 2
Search outside databases for aliases for TAF11 genePrevious GC identifers: GC06M034847 GC06M034892
Summaries for TAF11 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for TAF11 : Initiation of transcription by RNA polymerase II requires the activities of more than 70polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID),which binds to the core promoter to position the polymerase properly, serves as the scaffold forassembly of the remainder of the transcription complex, and acts as a channel for regulatorysignals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarilyconserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basaltranscription, serve as coactivators, function in promoter recognition or modify generaltranscription factors (GTFs) to facilitate complex assembly and transcription initiation. Thisgene encodes a small subunit of TFIID that is present in all TFIID complexes and interacts withTBP. This subunit also interacts with another small subunit, TAF13, to form a heterodimer with astructure similar to the histone core structure. [provided by RefSeq] UniProtKB/Swiss-Prot: TAF11_HUMAN, Q15544 Function : Core TAFII present in both of the previously described TFIID species which either lack orcontain TAFII30 (TFIID alpha and TFIID beta respectively)
Gene Wiki entry for TAF11
Genomic Location for TAF11
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
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Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the TAF11 gene Entrez Gene cytogenetic band: 6p21.31 Ensembl cytogenetic band: 6p21.31 HGNC cytogenetic band: 6p21 TAF11 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure
GeneLoc location for GC06M034953:
(about GC identifiers )
Start:
34,953,533 bp from pter
End:
34,963,797 bp from pter
Size:
10,265 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000006.10 NT_007592.14 Proteins for TAF11
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: TAF11_HUMAN, Q15544 (See
protein sequence )Recommended Name: Transcription initiation factor TFIID subunit 11 Size : 211 amino acids; 23307 Da
Subunit : TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors(TAFs). Interacts with TAF13 both in vitro and intracellularly; also interacts directly with TBP
Subcellular location : Nucleus
Sequence caution : Sequence=AAF22038.1; Type=Frameshift; Positions=208;
PDB structure from and Proteopedia : 1BH8 (3D)
 1BH9 (3D)
 
Secondary accessions : B2R8R3 Q9UHS0
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins: NP_005634.1 ENSEMBL proteins: ENSP00000354633 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: TAF11 3 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for TAF11: Assays for TAF11:
Protein
Domains/ Families for TAF11(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q15544 ProtoNet protein and cluster: Q15544
1 Blocks protein family : IPB006809 TAFII28-like protein UniProtKB/Swiss-Prot: TAF11_HUMAN, Q15544 Domain : TBP and TAFII18 bind to distinct domains of TAFII28Similarity : Belongs to the TAF11 family
Gene Function for TAF11
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005643 Applied Biosystems Silencer ® siRNAs for TAF11 Sigma-Aldrich siRNA for TAF11 Sigma-Aldrich shRNA for TAF11 Explore Sigma-Aldrich super-pooled esiRNAs               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005643                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005643                                  untagged cDNA clone in CMV expression vector: NM_005643  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005643 UniProtKB/Swiss-Prot: TAF11_HUMAN, Q15544 Function : Core TAFII present in both of the previously described TFIID species which either lack orcontain TAFII30 (TFIID alpha and TFIID beta respectively)
3 Gene Ontology (GO) molecular function terms (links to tree view) :
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Pathways & Interactions for TAF11
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for TAF11 (Your Favorite Gene powered by Ingenuity) Gene Network CentralTM Interacting Genes and Proteins Network for TAF11 5/86 Interacting proteins for TAF11 (ENSP00000354633 3 Q15544 1 , 2 ) via UniProtKB, MINT, and/or STRING (see all 86
)About this table 4 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006350 transcription
IEA -- GO:0006355 regulation of transcription, DNA-dependent
IEA -- GO:0006367 transcription initiation from RNA polymerase II promoter
IEA -- GO:0006368 RNA elongation from RNA polymerase II promoter
EXP 9405375
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Drugs & Compounds for TAF11 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Transcripts for TAF11(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005643 Sigma-Aldrich siRNA for TAF11 Sigma-Aldrich shRNA for TAF11 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_005643
REFSEQ mRNAs for TAF11 gene: NM_005643.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005643
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005643                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005643                                  untagged cDNA clone in CMV expression vector: NM_005643  
Additional cDNA sequence: AF118094.1 AK096675.1 AK302226.1 AK313475.1 BC021972.2 BT019404.1 BT019405.1 BX538195.1 BX647568.1 CR542068.1 CR601696.1 CR601826.1 CR603953.1 CR621043.1 D63705.1 X83928.1
10 DOTS entries : DT.447280 DT.95131854 DT.40292765 DT.100710244 DT.95173358 DT.95173349 DT.70105086 DT.102825292 DT.100719195 DT.97844283
24/214 AceView cDNA sequences (see all 214
):BP432562 AI192220 AI139931 AA384382 AA629347 BQ775406 AU135297 BQ669740 CD366593 BX647568 NM_005643 AI755269 BE797026 BQ670976 AA563801 CR621043 CA945144 AW069851 AW574835 BQ894217 BG682770 BX337015 BM915719 BQ669925
highest scoring ESTs for TAF11 :X83928 AA092006 AF118094 AI204671 AU129734 AW001008 AW239132 AW390144 AW408289 BC021972
Unigene Cluster for TAF11: TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa Hs.112444 [show with all ESTs ] Unigene Representative Sequence: BX647568 GeneLoc Exon Structure 1 Ensembl transcript including schematic representation : ENST00000361288
Expression for TAF11
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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TAF11 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for TAF11 1 / 2 / 3
9 probe-sets matching TAF11 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.112444 Expression variation in blood from EXPOLDB for TAF11
Orthologs for TAF11
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for TAF11 gene from 5/19 species (see all 19
)
About this table Species with no ortholog for TAF11 ENSEMBL Gene Tree for TAF11 Paralogs for TAF11 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for TAF11 gene LOC391742 2 Pseudogenes 3 related pseudogenes
SNPs/Variants for TAF11 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for TAF11 (up to first 250kb)
Disorders & Mutations for TAF11
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 600772
Medical News for TAF11 (Possibly Related Articles in
Doctor's Guide )
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Publications for TAF11 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/33 PubMed articles for TAF11 gene (see all 33
): Isolation and characterization of a cDNA encoding a human TFIID subunit containing a variety of putative structural motifs including direct repeats. (PubMed id 8820923) 2, 3, 4 Kuzuhara T. and Horikoshi M. (1996) Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID. (PubMed id 7729427) 2, 3, 4 Mengus G....Davidson I. (1995) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404) 3, 4 Mungall A.J.... Beck S. (2003) Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family. (PubMed id 9695952) 3, 4 Birck C.... Moras D. (1998) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332) 4 Matsuoka S.... Elledge S.J. (2007) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 4 Ota T....Sugano S. (2004) The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis. (PubMed id 14580349) 3 Guermah M.... Roeder R.G. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002) EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes. (PubMed id 9488465) 3 Bertolotti A....Tora L. (1998)
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AND OR
Aliases
TAF11 (Gene Symbol) MGC:15243 OTTHUMP00000016241 PRO2134 TAF(II)28 TAF2I TAFII-28 TAFII28 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28 kD TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa TAF11 RNA polymerase II, TATA box binding protein-associated factor, 28kDa TATA box binding protein (TBP)-associated factor, RNA polymerase II, I, 28kD TBP-associated factor 11 TFIID subunit p30-beta Transcription initiation factor TFIID 28 kDa subunit transcription initiation factor TFIID 28 kD subunit
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Genome Databases showing TAF11
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing TAF11
(According to HUGE )
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Specialized Databases showing TAF11 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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Name Description
NIEHS-SNPs http://egp.gs.washington.edu/data/taf11/
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