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Aliases for TAF11 Gene

Aliases for TAF11 Gene

  • TATA-Box Binding Protein Associated Factor 11 2 3 5
  • TAF11 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 28kDa 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, I, 28kD 2 3
  • Transcription Initiation Factor TFIID 28 KDa Subunit 3 4
  • TFIID Subunit P30-Beta 3 4
  • TAF(II)28 3 4
  • TAFII-28 3 4
  • TAFII28 3 4
  • TAF2I 3 4
  • Transcription Initiation Factor TFIID 28 KD Subunit 3
  • Transcription Initiation Factor TFIID Subunit 11 3
  • MGC:15243 3
  • PRO2134 3

External Ids for TAF11 Gene

Previous HGNC Symbols for TAF11 Gene

  • TAF2I

Previous GeneCards Identifiers for TAF11 Gene

  • GC06M034847
  • GC06M034892
  • GC06M034953
  • GC06M034568
  • GC06M034974
  • GC06M035239
  • GC06M035734
  • GC06M035589
  • GC06M035592
  • GC06M036292
  • GC06M036661

Summaries for TAF11 Gene

Entrez Gene Summary for TAF11 Gene

  • Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit of TFIID that is present in all TFIID complexes and interacts with TBP. This subunit also interacts with another small subunit, TAF13, to form a heterodimer with a structure similar to the histone core structure. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for TAF11 Gene

TAF11 (TATA-Box Binding Protein Associated Factor 11) is a Protein Coding gene. Diseases associated with TAF11 include Facioscapulohumeral Muscular Dystrophy 1. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and HIV Life Cycle. GO annotations related to this gene include sequence-specific DNA binding and transcription coactivator activity.

UniProtKB/Swiss-Prot for TAF11 Gene

  • Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively).

Gene Wiki entry for TAF11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF11 Gene

Genomics for TAF11 Gene

Regulatory Elements for TAF11 Gene

Enhancers for TAF11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F034951 1.1 Ensembl ENCODE 18.5 -65.9 -65889 4.4 MLX ARID4B YY1 ZNF121 FOS ZHX2 MIER2 PPARG KAT8 SMARCA4 TAF11 UHRF1BP1 SNRPC ANKS1A SCUBE3 GC06P039581 PIR53548
GH06F034990 1.1 ENCODE 15 -103.9 -103906 3.0 ZNF316 JUND TRIM24 NR2F2 UHRF1BP1 SCUBE3 TAF11 ANKS1A PIR39158 PIR43947 GC06P039566
GH06F034956 1.3 Ensembl ENCODE 11.7 -69.0 -69012 1.0 ZNF316 FEZF1 EMSY MAFK NR2F2 UHRF1BP1 TAF11 ANKS1A GC06P039581 PIR53548
GH06F034934 1 Ensembl ENCODE 11.3 -46.9 -46913 1.2 SCRT1 KLF1 MAFG NR2F2 ZNF316 ZFHX2 SCRT2 MAFK EMSY EGR2 ANKS1A TAF11 C6orf106 ENSG00000220643 UHRF1BP1 GC06P039581 PIR53548
GH06F034811 0.2 ENCODE 11.3 +76.5 76547 1.0 TBL1XR1 ZNF366 CBX5 SCRT2 FOS CREM JUNB ZEB2 TBX21 RAD51 UHRF1BP1 ANKS1A TAF11 C6orf106 ENSG00000220643 ENSG00000206717
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TAF11 on UCSC Golden Path with GeneCards custom track

Promoters for TAF11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001215035 -911 4401 PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2

Genomic Location for TAF11 Gene

Chromosome:
6
Start:
34,877,778 bp from pter
End:
34,888,089 bp from pter
Size:
10,312 bases
Orientation:
Minus strand

Genomic View for TAF11 Gene

Genes around TAF11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF11 Gene

Proteins for TAF11 Gene

  • Protein details for TAF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15544-TAF11_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 11
    Protein Accession:
    Q15544
    Secondary Accessions:
    • B2R8R3
    • B4DY18
    • Q9UHS0

    Protein attributes for TAF11 Gene

    Size:
    211 amino acids
    Molecular mass:
    23307 Da
    Quaternary structure:
    • TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts with TAF13 both in vitro and intracellularly; also interacts directly with TBP.
    SequenceCaution:
    • Sequence=AAF22038.1; Type=Frameshift; Positions=208; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TAF11 Gene

    Alternative splice isoforms for TAF11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TAF11 Gene

Post-translational modifications for TAF11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TAF11 Gene

No data available for DME Specific Peptides for TAF11 Gene

Domains & Families for TAF11 Gene

Protein Domains for TAF11 Gene

Graphical View of Domain Structure for InterPro Entry

Q15544

UniProtKB/Swiss-Prot:

TAF11_HUMAN :
  • TBP and TAFII18 bind to distinct domains of TAFII28.
  • Belongs to the TAF11 family.
Domain:
  • TBP and TAFII18 bind to distinct domains of TAFII28.
Family:
  • Belongs to the TAF11 family.
genes like me logo Genes that share domains with TAF11: view

No data available for Gene Families for TAF11 Gene

Function for TAF11 Gene

Molecular function for TAF11 Gene

UniProtKB/Swiss-Prot Function:
Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively).

Gene Ontology (GO) - Molecular Function for TAF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IDA 8670810
GO:0005515 protein binding IPI 7729427
GO:0042809 vitamin D receptor binding IPI 10744685
GO:0046966 thyroid hormone receptor binding IPI 10744685
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with TAF11: view
genes like me logo Genes that share phenotypes with TAF11: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TAF11 Gene

Localization for TAF11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAF11 Gene COMPARTMENTS Subcellular localization image for TAF11 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
cytosol 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TAF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex IDA 7729427
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with TAF11: view

Pathways & Interactions for TAF11 Gene

genes like me logo Genes that share pathways with TAF11: view

Gene Ontology (GO) - Biological Process for TAF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006368 transcription elongation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with TAF11: view

No data available for SIGNOR curated interactions for TAF11 Gene

Transcripts for TAF11 Gene

mRNA/cDNA for TAF11 Gene

Unigene Clusters for TAF11 Gene

TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAF11 Gene

No ASD Table

Relevant External Links for TAF11 Gene

GeneLoc Exon Structure for
TAF11
ECgene alternative splicing isoforms for
TAF11

Expression for TAF11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TAF11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TAF11 Gene

This gene is overexpressed in Stomach (62.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TAF11 Gene



Protein tissue co-expression partners for TAF11 Gene

NURSA nuclear receptor signaling pathways regulating expression of TAF11 Gene:

TAF11

SOURCE GeneReport for Unigene cluster for TAF11 Gene:

Hs.112444
genes like me logo Genes that share expression patterns with TAF11: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TAF11 Gene

Orthologs for TAF11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TAF11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF11 35 34
  • 99.68 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TAF11 34 35
  • 89.73 (n)
cow
(Bos Taurus)
Mammalia TAF11 34 35
  • 89.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TAF11 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Taf11 34 16 35
  • 84.68 (n)
rat
(Rattus norvegicus)
Mammalia Taf11 34
  • 84.04 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 75 (a)
OneToMany
-- 35
  • 71 (a)
OneToMany
-- 35
  • 71 (a)
OneToMany
chicken
(Gallus gallus)
Aves TAF11 34 35
  • 69.6 (n)
lizard
(Anolis carolinensis)
Reptilia TAF11 35
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia taf11 34
  • 74.4 (n)
Str.1018 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.8264 34
zebrafish
(Danio rerio)
Actinopterygii taf11 34 35
  • 74.88 (n)
Dr.15759 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5100 34
fruit fly
(Drosophila melanogaster)
Insecta Taf11 36 34 35
  • 63.44 (n)
worm
(Caenorhabditis elegans)
Secernentea taf-11.1 35
  • 23 (a)
OneToMany
taf-11.3 35
  • 22 (a)
OneToMany
taf-11.2 35
  • 19 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF11 35 37
  • 12 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2026 34
Species where no ortholog for TAF11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAF11 Gene

ENSEMBL:
Gene Tree for TAF11 (if available)
TreeFam:
Gene Tree for TAF11 (if available)

Paralogs for TAF11 Gene

No data available for Paralogs for TAF11 Gene

Variants for TAF11 Gene

Sequence variations from dbSNP and Humsavar for TAF11 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1051115 -- 34,887,971(-) CCCTC(C/G)AATCC upstream-variant-2KB, utr-variant-5-prime
rs10560116 -- 34,889,946(+) ATATC(-/TT)ATATA intron-variant, upstream-variant-2KB
rs111431950 -- 34,886,402(+) AACAA(A/C)AAACA intron-variant
rs111443055 -- 34,878,220(+) CTAGG(G/T)GATAG utr-variant-3-prime
rs112271383 -- 34,878,890(+) CTTTA(C/T)CATAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TAF11 Gene

Variant ID Type Subtype PubMed ID
dgv5955n100 CNV gain 25217958
esv2763967 CNV gain 21179565
nsv1026121 CNV gain 25217958
nsv462905 CNV gain 19166990
nsv508402 CNV deletion 20534489
nsv602906 CNV gain 21841781

Variation tolerance for TAF11 Gene

Residual Variation Intolerance Score: 54.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.35; 41.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAF11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAF11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF11 Gene

Disorders for TAF11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TAF11 Gene - From: DISEASES

Disorder Aliases PubMed IDs
facioscapulohumeral muscular dystrophy 1
  • facioscapulohumeral muscular dystrophy
- elite association - COSMIC cancer census association via MalaCards
Search TAF11 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TAF11

Genetic Association Database (GAD)
TAF11
Human Genome Epidemiology (HuGE) Navigator
TAF11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAF11
genes like me logo Genes that share disorders with TAF11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TAF11 Gene

Publications for TAF11 Gene

  1. Isolation and characterization of a cDNA encoding a human TFIID subunit containing a variety of putative structural motifs including direct repeats. (PMID: 8820923) Kuzuhara T. … Horikoshi M. (Biol. Pharm. Bull. 1996) 2 3 4 64
  2. Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID. (PMID: 7729427) Mengus G. … Davidson I. (EMBO J. 1995) 2 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  5. Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family. (PMID: 9695952) Birck C. … Moras D. (Cell 1998) 3 4 64

Products for TAF11 Gene

Sources for TAF11 Gene

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