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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TAF10 Gene

protein-coding GIFtS: 60
GCID: GC11M006627

TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated...

(Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase...)
(Previous symbols: TAF2H, TAF2A)

Explore 5 diseases affiliated with
TAF10 via

MalaCards

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Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
TAF10 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 30kDa¹ ²		STAF28² ³
TAF2A¹ ² ³ ⁵		TAF(II)30² ³
TAF2H¹ ² ³ ⁵		TAFII-30² ³
TAFII30¹ ² ³		Transcription Initiation Factor TFIID 30 KD Subunit²
TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, H, 30kD¹ ²		Transcription Initiation Factor TFIID Subunit 10²
Transcription Initiation Factor TFIID 30 KDa Subunit² ³

External Ids:	HGNC: 11543¹	Entrez Gene: 6881²	Ensembl: ENSG00000166337⁷	OMIM: 600475⁵	UniProtKB: Q12962³

ORGUL members:
	NONCODE:n340956

Export aliases for TAF10 gene to outside databases

Previous GC identifers: GC11M007375 GC11M007092 GC11M006586 GC11M006596 GC11M006588 GC11M006291

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TAF10:

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that

coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the

polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a

channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily

conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as

coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex

assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a

subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for

transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required

for certain cellular differentiation programs. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TAF10_HUMAN, Q12962

Function: TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and

TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter

responses to various activators and repressors

Gene Wiki entry for TAF10

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TAF10 gene promoter:
CRE-BP1 ATF-2 STAT3 ATF
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for TAF10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAF10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.3 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.5-p15.2

TAF10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAF10 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M006627: view genomic region (about GC identifiers)

Start:	6,627,526 bp from pter	End:	6,633,898 bp from pter
Size:	6,373 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TAF10_HUMAN, Q12962 (See protein sequence)

Recommended Name: Transcription initiation factor TFIID subunit 10

Size: 218 amino acids; 21711 Da

Subunit: TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP

is not part of TFTC. Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, SUPT3H, TAF5L

TAF6L, TAF9, TAF10, TAF12 and TRRAP. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L,

SUPT3H, TAF2, TAF4, TAF5, GCN5L2/GCN5, TAF10 and TRRAP. Component of the STAGA transcription coactivator-HAT complex,

at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core

complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22.

Interacts with TAF3

Subcellular location: Nucleus

6/8 PDB 3D structures from and Proteopedia for TAF10 (see all 8):

3M53 (3D)

3M54 (3D)

3M55 (3D)

3M56 (3D)

3M57 (3D)

3M58 (3D)

Secondary accessions: O00703 Q13175 Q6FH13

Explore the universe of human proteins at neXtProt for TAF10: NX_Q12962

Post-translational modifications:

Monomethylated at Lys-189 by SETD7, leading to increase its affinity for RNA polymerase II¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q12962

TAF10 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_006275.1

ENSEMBL proteins:

ENSP00000299424

Reactome Protein details: Q12962
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	Uscn Proteins for TAF10

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000125	PCAF complex	IDA	9674425
GO:0005634	nucleus	IDA	15099517
GO:0005654	nucleoplasm	TAS	--
GO:0005669	transcription factor TFIID complex	IDA	15099517
GO:0005737	cytoplasm	IDA	15870280

TAF10 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TAF10 for domains About GeneDecksing

1 InterPro domain/family:

IPR003923 TFIID_30kDa

Graphical View of Domain Structure for InterPro Entry Q12962

ProtoNet protein and cluster: Q12962

1 Blocks protein family: IPB003923 Transcription initiation factor TFIID 23-30kDa subunit signature

UniProtKB/Swiss-Prot: TAF10_HUMAN, Q12962

Domain: The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase

Similarity: Belongs to the TAF10 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TAF10_HUMAN, Q12962

Function: TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and

TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter

responses to various activators and repressors

miRNA Products:		miRTarBase miRNAs that target TAF10: hsa-mir-491-5p (MIRT004657)

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In Situ Assay
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Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for TAF10

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	contributes to sequence-specific DNA binding transcription factor activity	IDA	9603525
GO:0003713	transcription coactivator activity	IDA	11564863
GO:0004402	contributes to histone acetyltransferase activity	IDA	9674425
GO:0005515	contributes to protein binding	IPI	15870280
GO:0019899	enzyme binding	IPI	16415881

TAF10 for ontologies About GeneDecksing

3 GenomeRNAi human phenotypes for TAF10:

Decreased TP53 protein express

Decreased viability

Increased cell death HMECs cel

Animal Models:
Mouse knock-out Taf10^tm1.1Lzt for TAF10
6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Taf10):

cellular	embryogenesis	growth/size	homeostasis/metabolism	integument
mortality/aging

TAF10 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Formation of RNA Pol II elongation complex

8/12 pathways (see all 12)
RNA Polymerase II Pre-transcription Events	0.72	Addition of the third nucleotide on the nascent transcript	0.40
Transcription of the HIV genome	0.70	RNA Polymerase II Promoter Escape	0.40
RNA Polymerase II Transcription Initiation And Promoter Clearance	0.40	RNA Polymerase II Transcription Initiation	0.40
HIV-1 Transcription Initiation	0.40	Addition of the fourth nucleotide on the Nascent Transcript: Second Transition	0.40

Assembly of RNA Polymerase-II Initiation Complex

Assembly of RNA Polymerase-II Initiation Complex	1.00	Basal transcription factors	0.49
Transcription of mRNA	0.91	Crosstalk Between CARM1 and ESRs	0.32
Protein Acetylation and Deacetylation	0.51

HIV Infection

	HIV Infection	1.00			Transcription Ligand-Dependent Transcription of Retinoid-Target genes	0.28
	Transcription_Ligand-Dependent Transcription of Retinoid-Target genes	0.28

Late Phase of HIV Life Cycle

Late Phase of HIV Life Cycle

1.00

HIV Life Cycle

0.90

Transcription

Transcription

1.00

RNA Polymerase II Transcription

0.69

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for TAF10

	Histone modification
	Transcription Ligand-Dependent Transcription of Retinoid-Target genes

5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TAF10 (see all 7)

	Nuclear Receptor Activation by Vitamin-A
	Protein Acetylation and Deacetylation
	Assembly of RNA Polymerase-II Initiation Complex
	Glucocorticoid Receptor Signaling
	Estrogen Pathway

1 GeneGo (Thomson Reuters) Pathway for TAF10

Transcription Ligand-Dependent Transcription of Retinoid-Target genes

2 BioSystems Pathways for TAF10

	C-MYC pathway
	Validated targets of C-MYC transcriptional activation

5/19 Reactome Pathways for TAF10 (see all 19)

	Late Phase of HIV Life Cycle
	RNA Polymerase II Transcription
	RNA Polymerase II Transcription Initiation And Promoter Clearance
	Disease
	HIV Infection

1 Kegg Pathway (Kegg details for TAF10):

Basal transcription factors

TAF10 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TAF10

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/105 Interacting proteins for TAF10 (Q12962^{1, 2, 3} ENSP00000299424⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 105)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FTL	P02792²^,³, ENSP00000366525⁴	MINT-63359 I2D: score=5 STRING: ENSP00000366525
SETD7	Q8WTS6¹^,³, ENSP00000274031⁴	EBI-708376,EBI-1268586 I2D: score=3 STRING: ENSP00000274031
ATXN7	O15265¹^,³, ENSP00000381590⁴	EBI-708376,EBI-3866216 I2D: score=2 STRING: ENSP00000381590
TAF9	Q16594³, ENSP00000217893⁴	I2D: score=2 STRING: ENSP00000370201 STRING: ENSP00000217893
TBP	P20226³, ENSP00000230354⁴	I2D: score=5 STRING: ENSP00000230354

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006352	DNA-dependent transcription, initiation	IDA	9212049
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0006366	transcription from RNA polymerase II promoter	TAS	--
GO:0006367	transcription initiation from RNA polymerase II promoter	TAS	--
GO:0006368	transcription elongation from RNA polymerase II promoter	TAS	--

TAF10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TAF10
Search CenterWatch for drugs/clinical trials and news about TAF10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TAF10 gene:

NM_006284.3

Unigene Cluster for TAF10:

TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa

Hs.5158 [show with all ESTs]

Unigene Representative Sequence: AL833496

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000526743 ENST00000299424(uc001mej.2) ENST00000527248 ENST00000531760

ENST00000532344

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Additional cDNA sequence:

AK310989.1 AL833496.1 BC012088.1 CR541943.1 U13991.1

17 DOTS entries:

DT.112870 DT.95173144 DT.97802133 DT.449776 DT.120709447 DT.70101889 DT.100038213 DT.452885

DT.92447059 DT.92447057 DT.100886845 DT.120709302 DT.100886859 DT.120709507 DT.100886848 DT.100886863

DT.95213307

24/433 AceView cDNA sequences (see all 433):

AI800096 BM840121 CR619836 BF514923 BX417992 AW793577 AI581795 AI633781

BM772785 AW793578 BE297102 BU932042 AW470062 AI337083 BQ072896 BX089762

BM559236 BM984948 BE612595 BM801225 CR619123 BQ957754 BU188116 CR597361

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for TAF10 About this scheme

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	^	3a	·	3b	^	4a	·	4b	^	5
SP1:									-
SP2:
SP3:
SP4:

ECgene alternative splicing isoforms for TAF10

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TAF10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCCCACACC

About this image
See TAF10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TAF10

SOURCE GeneReport for Unigene cluster: Hs.5158

SABiosciences Custom PCR Arrays for TAF10

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TAF10 gene from 8/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Taf10^{1 , 5}	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated more^{1, 5}	90.67(n)¹ 91.74(a)¹		7 (55.97 cM)⁵ 24075¹ NM_020024.3¹ NP_064408.2¹ 105739393⁵
lizard (Anolis carolinensis)	Reptilia	TAF10⁶	--	60(a)	1 ↔ 1	AAWZ02038015(7210-11181)
African clawed frog (Xenopus laevis)	Amphibia	Xl.23803²	Xenopus laevis transcribed sequence with weak similarity more	79.33(n)		48029036
zebrafish (Danio rerio)	Actinopterygii	taf10¹	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated more	66.87(n) 75.15(a)		556710 NM_001044811.2 NP_001038276.1
fruit fly (Drosophila melanogaster)	Insecta	Taf10b³ Taf10¹	transcription initiation from Pol II promoter more³ TBP-associated factor 10¹	62(a)³ 63.64(n)¹ 62.73(a)¹		23A5³ 33469¹ NM_058115.4¹ NP_477463.1¹
worm (Caenorhabditis elegans)	Secernentea	taf-10⁶	TAF (TBP-associated transcription factor) family m...	36(a)	1 ↔ 1	V(4687093-4688014)
thale cress (Arabidopsis thaliana)	eudicotyledons	TAFII15¹	TBP-associated factor II 15	52.61(n) 51.96(a)		829300 NM_119321.3 NP_194900.1
rice (Oryza sativa)	Liliopsida	Os09g0431500¹	hypothetical protein	52.72(n) 49.65(a)		4347127 NM_001069773.1 NP_001063238.1

ENSEMBL Gene Tree for TAF10 (if available)
TreeFam Gene Tree for TAF10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TAF10 gene

TAF10 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for TAF10
PGOHUM00000239724 PGOHUM00000246067

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs199856833^1,2		--	6632624(+)	`ATGCGG/TGGGTC`	2	P	syn¹		0	--	--	--	--
rs190877277^1,2	C,	--	6632669(+)	`CCAGTC/GACTGC`	2	V	syn¹		0	--	--	--	--
rs1876300^1,2	C,F,A,H,	--	6632857(+)	`TTTTGA/TCAGCA`	1	--	int¹		20		NS EA NA WA EU	4047
rs182151442^1,2	C,	--	6632874(+)	`GTGGCC/GTTGTT`	1	--	int¹		0	--	--	--	--
rs111269422^1,2	C	--	6632894(+)	`GCCCAC/G/TCGTAG`	1	--	spd¹		1		CSA	1
rs201684203^1,2		--	6632953(+)	`ACACCA/CCGGGC`	2	G V	mis¹		0	--	--	--	--
rs150347033^1,2	C,F,	--	6632991(+)	`AGTACG/ATAAAC`	2	/Y	syn¹		2		NA EU	4511
rs3176311^1,2	C,F,H,	--	6633007(-)	`GGCCAT/CATCTA`	2	/T /I	mis¹ ese³		8		NS EA NA EU	905
rs201656714^1,2		--	6633010(+)	`ATATGG/TCCCCC`	2	D A	mis¹		0	--	--	--	--
rs201261890^1,2		--	6633090(+)	`GGAGGC/TGCAGG`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TAF10 (6627526 - 6633898 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TAF10: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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TAF10 for disorders           About GeneDecksing

OMIM gene information: 600475    OMIM disorders: --

5 diseases for TAF10:    About MalaCards

epidermodysplasia verruciformis fanconi's anemia progeria anemia

immunodeficiency

Export disorders for TAF10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TAF10 gene, integrated from 9 sources (see all 58):
(articles sorted by number of sources associating them with TAF10)

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Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor. (PubMed id 7923369)^{1, 2, 3} Jacq X.... Tora L. (1994)
Organization and chromosomal localization of the gene (TAF2H) encoding the human TBP-associated factor II 30 (TAFII30). (PubMed id 8530084)^{1, 2, 9} Scheer E.... Tora L. (1995)
A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. (PubMed id 18206972)^{1, 2} Zhao Y.... Devys D. (2008)
Structural basis for the methylation site specificity of SET7/9. (PubMed id 16415881)^{1, 2} Couture J.-F.... Trievel R.C. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Gene-specific modulation of TAF10 function by SET9-mediated methylation. (PubMed id 15099517)^{1, 2} Kouskouti A....Talianidis I. (2004)
Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one- dimensional gel electrophoresis. (PubMed id 12601814)^{1, 2} Cavusoglu N.... van Dorsselaer A. (2003)
Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage- binding factors in vivo. (PubMed id 11564863)^{1, 2} Martinez E.... Roeder R.G. (2001)
The TFIID components human TAFII140 and Drosophila BIP2 (TAFII155) are novel metazoan homologues of yeast TAFII47 containing a histone fold and a PHD finger. (PubMed id 11438666)^{1, 2} Gangloff Y.G.... Davidson I. (2001)
Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction. (PubMed id 10373431)^{1, 2} Brand M.... Tora L. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 6881	HGNC: 11543	AceView: TAF10andKIAA0409	Ensembl:ENSG00000166337	euGenes: HUgn6881
ECgene: TAF10	Kegg: 6881	H-InvDB: TAF10

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TAF10	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for TAF10	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/taf10/

Intellectual Property for TAF10 gene
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Patent Information for TAF10 gene:
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