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Aliases for TAF10 Gene

Aliases for TAF10 Gene

  • TATA-Box Binding Protein Associated Factor 10 2 3 5
  • TAF10 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 30kDa 2 3
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, H, 30kD 2 3
  • Transcription Initiation Factor TFIID 30 KDa Subunit 3 4
  • TAF(II)30 3 4
  • TAFII-30 3 4
  • TAFII30 3 4
  • STAF28 3 4
  • TAF2A 3 4
  • TAF2H 3 4
  • Transcription Initiation Factor TFIID 30 KD Subunit 3
  • Transcription Initiation Factor TFIID Subunit 10 3

External Ids for TAF10 Gene

Previous HGNC Symbols for TAF10 Gene

  • TAF2H
  • TAF2A

Previous GeneCards Identifiers for TAF10 Gene

  • GC11M007375
  • GC11M007092
  • GC11M006586
  • GC11M006596
  • GC11M006588
  • GC11M006291

Summaries for TAF10 Gene

Entrez Gene Summary for TAF10 Gene

  • Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAF10 Gene

TAF10 (TATA-Box Binding Protein Associated Factor 10) is a Protein Coding gene. Among its related pathways are HIV Life Cycle and PEDF Induced Signaling. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription coactivator activity.

UniProtKB/Swiss-Prot for TAF10 Gene

  • TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.

Gene Wiki entry for TAF10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF10 Gene

Genomics for TAF10 Gene

Regulatory Elements for TAF10 Gene

Enhancers for TAF10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G006742 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -132.6 -132566 6.5 HDAC1 TBP PKNOX1 CBX3 NFRKB YBX1 TCF12 ZNF766 GATA2 CBX5 RRP8 OR2AG2 CAVIN3 ILK DCHS1 TAF10 ENSG00000254641 OR10A4 APBB1 SMPD1
GH11G006693 1.4 Ensembl ENCODE dbSUPER 10.2 -82.3 -82333 3.3 HDAC1 PKNOX1 TCF12 ZNF121 GATA2 FOS CAVIN1 ZBTB11 HDAC8 NR2F2 GVINP2 OR2AG2 ILK RRP8 ENSG00000254400 TAF10 ENSG00000254641 APBB1 SMPD1 GC11P006694
GH11G006667 1 Ensembl ENCODE 10.8 -55.4 -55362 1.1 CTCF ESRRA CBX3 CEBPG EBF1 RAD21 RELA ZNF143 SMC3 RELB ENSG00000254641 TAF10 ILK RRP8 GC11P006673 DCHS1
GH11G006575 1 Ensembl ENCODE 10.6 +35.9 35858 2.0 CTCF JUN ZMYM3 MAX ARID4B CEBPG RAD21 YY1 PATZ1 HNF4G ILK RRP8 ENSG00000254400 ENSG00000254641 TAF10 PIR42127 DNHD1
GH11G006531 0.8 ENCODE 11 +81.2 81212 0.2 HDAC1 ELF3 HDGF FOXA2 ARNT RAD21 SCRT2 ZNF143 ZNF654 REST RRP8 ILK MRPL17 RPL21P94 ENSG00000254641 TAF10 ENSG00000255410 ARFIP2 TIMM10B APBB1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TAF10 on UCSC Golden Path with GeneCards custom track

Promoters for TAF10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000036316 44 1601 HNRNPUL1 HDGF PKNOX1 FOXA2 MLX CREB3L1 AGO1 ARID4B SIN3A DMAP1

Genomic Location for TAF10 Gene

Chromosome:
11
Start:
6,606,296 bp from pter
End:
6,612,667 bp from pter
Size:
6,372 bases
Orientation:
Minus strand

Genomic View for TAF10 Gene

Genes around TAF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TAF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TAF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF10 Gene

Proteins for TAF10 Gene

  • Protein details for TAF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12962-TAF10_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 10
    Protein Accession:
    Q12962
    Secondary Accessions:
    • O00703
    • Q13175
    • Q6FH13

    Protein attributes for TAF10 Gene

    Size:
    218 amino acids
    Molecular mass:
    21711 Da
    Quaternary structure:
    • TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC. Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, SUPT3H, TAF5L TAF6L, TAF9, TAF10, TAF12 and TRRAP. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H, TAF2, TAF4, TAF5, GCN5L2/GCN5, TAF10 and TRRAP. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22. Interacts with TAF3.

    Three dimensional structures from OCA and Proteopedia for TAF10 Gene

neXtProt entry for TAF10 Gene

Post-translational modifications for TAF10 Gene

  • Monomethylated at Lys-189 by SETD7, leading to increase its affinity for RNA polymerase II.
  • Ubiquitination at posLast=161161
  • Modification sites at PhosphoSitePlus

Other Protein References for TAF10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TAF10 Gene

Domains & Families for TAF10 Gene

Gene Families for TAF10 Gene

Protein Domains for TAF10 Gene

Suggested Antigen Peptide Sequences for TAF10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12962

UniProtKB/Swiss-Prot:

TAF10_HUMAN :
  • The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase.
  • Belongs to the TAF10 family.
Domain:
  • The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase.
Family:
  • Belongs to the TAF10 family.
genes like me logo Genes that share domains with TAF10: view

Function for TAF10 Gene

Molecular function for TAF10 Gene

UniProtKB/Swiss-Prot Function:
TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors.

Gene Ontology (GO) - Molecular Function for TAF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 contributes_to transcription factor activity, sequence-specific DNA binding IDA 9603525
GO:0003713 transcription coactivator activity IDA 11564863
GO:0004402 contributes_to histone acetyltransferase activity IDA 9674425
GO:0005515 contributes_to protein binding IPI 15870280
genes like me logo Genes that share ontologies with TAF10: view
genes like me logo Genes that share phenotypes with TAF10: view

Animal Models for TAF10 Gene

MGI Knock Outs for TAF10:

Animal Model Products

CRISPR Products

miRNA for TAF10 Gene

miRTarBase miRNAs that target TAF10

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TAF10 Gene

Localization for TAF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TAF10 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TAF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000125 PCAF complex IDA 9674425
GO:0005634 nucleus IDA,IEA 11564863
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex IDA 7729427
GO:0005737 cytoplasm IDA 15870280
genes like me logo Genes that share ontologies with TAF10: view

Pathways & Interactions for TAF10 Gene

genes like me logo Genes that share pathways with TAF10: view

Gene Ontology (GO) - Biological Process for TAF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle IEA --
GO:0001889 liver development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006352 DNA-templated transcription, initiation IDA,IEA 9212049
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TAF10: view

No data available for SIGNOR curated interactions for TAF10 Gene

Drugs & Compounds for TAF10 Gene

No Compound Related Data Available

Transcripts for TAF10 Gene

Unigene Clusters for TAF10 Gene

TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TAF10 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5
SP1: -
SP2:
SP3:
SP4:

Relevant External Links for TAF10 Gene

GeneLoc Exon Structure for
TAF10
ECgene alternative splicing isoforms for
TAF10

Expression for TAF10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TAF10 Gene

mRNA differential expression in normal tissues according to GTEx for TAF10 Gene

This gene is overexpressed in Whole Blood (x4.0).

Protein differential expression in normal tissues from HIPED for TAF10 Gene

This gene is overexpressed in Liver (26.2) and Breast (12.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TAF10 Gene



Protein tissue co-expression partners for TAF10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TAF10 Gene:

TAF10

SOURCE GeneReport for Unigene cluster for TAF10 Gene:

Hs.5158

Evidence on tissue expression from TISSUES for TAF10 Gene

  • Kidney(4.5)
  • Liver(4.5)
  • Muscle(3)
  • Nervous system(2.8)
  • Heart(2.6)
  • Intestine(2.5)
  • Stomach(2.5)
genes like me logo Genes that share expression patterns with TAF10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TAF10 Gene

Orthologs for TAF10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TAF10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF10 34 35
  • 97.86 (n)
oppossum
(Monodelphis domestica)
Mammalia TAF10 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAF10 34 35
  • 94.5 (n)
cow
(Bos Taurus)
Mammalia TAF10 34 35
  • 93.73 (n)
mouse
(Mus musculus)
Mammalia Taf10 34 16 35
  • 90.67 (n)
Gm4799 35
  • 90 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Taf10 34
  • 90.06 (n)
lizard
(Anolis carolinensis)
Reptilia TAF10 35
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia taf10 34
  • 76.55 (n)
Str.6326 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.23803 34
zebrafish
(Danio rerio)
Actinopterygii taf10 34 35
  • 69.84 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10113 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008612 34
  • 67.97 (n)
fruit fly
(Drosophila melanogaster)
Insecta Taf10 34
  • 63.64 (n)
Taf10b 36 35
  • 62 (a)
worm
(Caenorhabditis elegans)
Secernentea taf-10 35
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF10 35 37
  • 25 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons TAFII15 34
  • 52.61 (n)
rice
(Oryza sativa)
Liliopsida Os09g0431500 34
  • 54.58 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7978 35
  • 52 (a)
OneToOne
Species where no ortholog for TAF10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAF10 Gene

ENSEMBL:
Gene Tree for TAF10 (if available)
TreeFam:
Gene Tree for TAF10 (if available)

Paralogs for TAF10 Gene

Pseudogenes.org Pseudogenes for TAF10 Gene

genes like me logo Genes that share paralogs with TAF10: view

No data available for Paralogs for TAF10 Gene

Variants for TAF10 Gene

Sequence variations from dbSNP and Humsavar for TAF10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs188148381 Uncertain significance 6,613,560(+) CAAGA(C/G)AATAT upstream-variant-2KB, utr-variant-3-prime
rs188544089 Uncertain significance 6,613,118(+) ACTTG(A/G)CCCAG upstream-variant-2KB, utr-variant-3-prime
rs201122774 Uncertain significance 6,614,234(+) CACAG(A/G)GTCTG upstream-variant-2KB, utr-variant-3-prime
rs202155605 Uncertain significance 6,614,232(+) TGCAC(-/A)GAGTC upstream-variant-2KB, utr-variant-3-prime
rs369352772 Uncertain significance 6,612,976(-) GTTAA(C/T)GCCCT upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TAF10 Gene

Variant ID Type Subtype PubMed ID
esv996362 CNV deletion 20482838
nsv1035138 CNV gain 25217958
nsv553373 CNV loss 21841781
nsv825755 CNV gain 20364138

Variation tolerance for TAF10 Gene

Residual Variation Intolerance Score: 31.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.23; 24.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TAF10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TAF10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TAF10 Gene

Disorders for TAF10 Gene

Relevant External Links for TAF10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TAF10

No disorders were found for TAF10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TAF10 Gene

Publications for TAF10 Gene

  1. Organization and chromosomal localization of the gene (TAF2H) encoding the human TBP-associated factor II 30 (TAFII30). (PMID: 8530084) Scheer E. … Tora L. (Genomics 1995) 3 4 22 64
  2. Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor. (PMID: 7923369) Jacq X. … Tora L. (Cell 1994) 2 3 4 64
  3. A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. (PMID: 18206972) Zhao Y. … Devys D. (Mol. Cell 2008) 3 4 64
  4. Identification of a small TAF complex and its role in the assembly of TAF-containing complexes. (PMID: 17375202) Demeny M.A. … Tora L. (PLoS ONE 2007) 3 22 64
  5. Structural basis for the methylation site specificity of SET7/9. (PMID: 16415881) Couture J.-F. … Trievel R.C. (Nat. Struct. Mol. Biol. 2006) 3 4 64

Products for TAF10 Gene

Sources for TAF10 Gene

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