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Aliases for TAF10 Gene

Aliases for TAF10 Gene

  • TAF10 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 30kDa 2 3
  • TAF2A 3 4 6
  • TAF2H 3 4 6
  • TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, H, 30kD 2 3
  • Transcription Initiation Factor TFIID 30 KDa Subunit 3 4
  • TAF(II)30 3 4
  • TAFII-30 3 4
  • TAFII30 3 4
  • STAF28 3 4
  • Transcription Initiation Factor TFIID 30 KD Subunit 3
  • Transcription Initiation Factor TFIID Subunit 10 3

External Ids for TAF10 Gene

Previous Symbols for TAF10 Gene

  • TAF2H
  • TAF2A

Summaries for TAF10 Gene

Entrez Gene Summary for TAF10 Gene

  • Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs. [provided by RefSeq, Jul 2008]

GeneCards Summary for TAF10 Gene

TAF10 (TAF10 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 30kDa) is a Protein Coding gene. Among its related pathways are Disease and GPCR Pathway. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription coactivator activity.

UniProtKB/Swiss-Prot for TAF10 Gene

  • TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors

Gene Wiki entry for TAF10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TAF10 Gene

Genomics for TAF10 Gene

Genomic Location for TAF10 Gene

Start:
6,606,296 bp from pter
End:
6,612,667 bp from pter
Size:
6,372 bases
Orientation:
Minus strand

Genomic View for TAF10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TAF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TAF10 Gene

Regulatory Elements for TAF10 Gene

Proteins for TAF10 Gene

  • Protein details for TAF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12962-TAF10_HUMAN
    Recommended name:
    Transcription initiation factor TFIID subunit 10
    Protein Accession:
    Q12962
    Secondary Accessions:
    • O00703
    • Q13175
    • Q6FH13

    Protein attributes for TAF10 Gene

    Size:
    218 amino acids
    Molecular mass:
    21711 Da
    Quaternary structure:
    • TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC. Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, SUPT3H, TAF5L TAF6L, TAF9, TAF10, TAF12 and TRRAP. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H, TAF2, TAF4, TAF5, GCN5L2/GCN5, TAF10 and TRRAP. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. The STAGA core complex is associated with a subcomplex required for histone deubiquitination composed of ATXN7L3, ENY2 and USP22. Interacts with TAF3.

    Three dimensional structures from OCA and Proteopedia for TAF10 Gene

neXtProt entry for TAF10 Gene

Proteomics data for TAF10 Gene at MOPED

Post-translational modifications for TAF10 Gene

  • Monomethylated at Lys-189 by SETD7, leading to increase its affinity for RNA polymerase II
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys161

Other Protein References for TAF10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TAF10 Gene

Domains for TAF10 Gene

Protein Domains for TAF10 Gene

UniProtKB/Swiss-Prot:

TAF10_HUMAN
Domain:
  • The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase:
    • Q12962
Family:
  • Belongs to the TAF10 family.:
    • Q12962
genes like me logo Genes that share domains with TAF10: view

No data available for Gene Families for TAF10 Gene

Function for TAF10 Gene

Molecular function for TAF10 Gene

UniProtKB/Swiss-Prot Function: TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors

Gene Ontology (GO) - Molecular Function for TAF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 contributes_to sequence-specific DNA binding transcription factor activity IDA 9603525
GO:0003713 transcription coactivator activity IDA 11564863
GO:0004402 contributes_to histone acetyltransferase activity IDA 11564863
GO:0005515 contributes_to protein binding IPI 15870280
GO:0019899 enzyme binding IPI 16415881
genes like me logo Genes that share ontologies with TAF10: view
genes like me logo Genes that share phenotypes with TAF10: view

Animal Models for TAF10 Gene

MGI Knock Outs for TAF10:

miRNA for TAF10 Gene

miRTarBase miRNAs that target TAF10

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TAF10 Gene

Localization for TAF10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TAF10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TAF10 Gene COMPARTMENTS Subcellular localization image for TAF10 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TAF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000125 PCAF complex IDA 9674425
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005669 transcription factor TFIID complex IDA 14580349
GO:0005737 cytoplasm IDA 15870280
genes like me logo Genes that share ontologies with TAF10: view

Pathways for TAF10 Gene

genes like me logo Genes that share pathways with TAF10: view

Gene Ontology (GO) - Biological Process for TAF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006352 DNA-templated transcription, initiation IDA 9212049
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
genes like me logo Genes that share ontologies with TAF10: view

Transcripts for TAF10 Gene

Unigene Clusters for TAF10 Gene

TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TAF10 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5
SP1: -
SP2:
SP3:
SP4:

Relevant External Links for TAF10 Gene

GeneLoc Exon Structure for
TAF10
ECgene alternative splicing isoforms for
TAF10

Expression for TAF10 Gene

mRNA expression in normal human tissues for TAF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TAF10 Gene

This gene is overexpressed in Whole Blood (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TAF10 Gene

SOURCE GeneReport for Unigene cluster for TAF10 Gene Hs.5158

genes like me logo Genes that share expressions with TAF10: view

Orthologs for TAF10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TAF10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TAF10 36
  • 97.86 (n)
  • 98.17 (a)
TAF10 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TAF10 36
  • 93.73 (n)
  • 95.41 (a)
TAF10 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TAF10 36
  • 94.5 (n)
  • 97.25 (a)
TAF10 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm4799 37
  • 90 (a)
OneToMany
Taf10 36
  • 90.67 (n)
  • 91.74 (a)
Taf10 16
Taf10 37
  • 92 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia TAF10 37
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Taf10 36
  • 90.06 (n)
  • 93.12 (a)
lizard
(Anolis carolinensis)
Reptilia TAF10 37
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23803 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6326 36
taf10 36
  • 76.55 (n)
  • 88.28 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10113 36
zebrafish
(Danio rerio)
Actinopterygii taf10 36
  • 69.84 (n)
  • 80.95 (a)
taf10 37
  • 67 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008612 36
  • 67.97 (n)
  • 72.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta Taf10 36
  • 63.64 (n)
  • 62.73 (a)
Taf10b 37
  • 52 (a)
OneToOne
Taf10b 38
  • 62 (a)
worm
(Caenorhabditis elegans)
Secernentea taf-10 37
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAF10 37
  • 25 (a)
OneToOne
TAF10 39
thale cress
(Arabidopsis thaliana)
eudicotyledons TAFII15 36
  • 52.61 (n)
  • 51.96 (a)
rice
(Oryza sativa)
Liliopsida Os09g0431500 36
  • 54.58 (n)
  • 52.94 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7978 37
  • 52 (a)
OneToOne
Species with no ortholog for TAF10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TAF10 Gene

ENSEMBL:
Gene Tree for TAF10 (if available)
TreeFam:
Gene Tree for TAF10 (if available)

Paralogs for TAF10 Gene

Pseudogenes.org Pseudogenes for TAF10 Gene

genes like me logo Genes that share paralogs with TAF10: view

No data available for Paralogs for TAF10 Gene

Variants for TAF10 Gene

Sequence variations from dbSNP and Humsavar for TAF10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1131872 -- 6,611,971(-) GCTGA(A/G)CGGCG synonymous-codon, reference
rs1802670 -- 6,611,703(-) CCTTT(G/T)GTGGA reference, missense
rs1876300 -- 6,611,626(+) TTTTG(A/T)CAGCA intron-variant
rs3176310 -- 6,611,934(-) GAGGG(A/C)GAGGG intron-variant
rs3176311 - 6,611,776(-) GGCCA(C/T)ATCTA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for TAF10 Gene

Variant ID Type Subtype PubMed ID
nsv825755 CNV Gain 20364138
esv996362 CNV Deletion 20482838
nsv896971 CNV Loss 21882294
nsv896972 CNV Loss 21882294

Relevant External Links for TAF10 Gene

HapMap Linkage Disequilibrium report
TAF10

Disorders for TAF10 Gene

No disorders were found for TAF10 Gene.

No data available for UniProtKB/Swiss-Prot for TAF10 Gene

Publications for TAF10 Gene

  1. Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor. (PMID: 7923369) Jacq X. … Tora L. (Cell 1994) 2 3 4
  2. Organization and chromosomal localization of the gene (TAF2H) encoding the human TBP-associated factor II 30 (TAFII30). (PMID: 8530084) Scheer E. … Tora L. (Genomics 1995) 3 4 23
  3. Assignment of the human TAFII30 gene (TAF2H) to human chromosome band 11p15.3 using somatic cell hybrids. (PMID: 9154123) ChAchensse V. … Henry I. (Cytogenet. Cell Genet. 1997) 3 23
  4. Histone-like TAFs within the PCAF histone acetylase complex. (PMID: 9674425) Ogryzko V.V. … Nakatani Y. (Cell 1998) 3 4
  5. The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily. (PMID: 9885574) Vassilev A. … Nakatani Y. (Mol. Cell 1998) 3 4

Products for TAF10 Gene

Sources for TAF10 Gene

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