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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TAF10 Gene

protein-coding   GIFtS: 63
GCID: GC11M006627

TAF10 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated...

(Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase...)
(Previous symbols: TAF2H, TAF2A)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
TAF10 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated
Factor, 30kDa1 2
     TAF(II)302 3
TAF2A1 2 3 5     TAFII-302 3
TAF2H1 2 3 5     TAFII302 3
TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, H,
30kD1 2
     Transcription Initiation Factor TFIID 30 KD Subunit2
Transcription Initiation Factor TFIID 30 KDa Subunit2 3     Transcription Initiation Factor TFIID Subunit 102
STAF282 3     

External Ids:    HGNC: 115431   Entrez Gene: 68812   Ensembl: ENSG000001663377   OMIM: 6004755   UniProtKB: Q129623   
ORGUL members:         
NONCODE14:n340956      

Export aliases for TAF10 gene to outside databases

Previous GC identifers: GC11M007375 GC11M007092 GC11M006586 GC11M006596 GC11M006588 GC11M006291


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TAF10 Gene:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein
that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to
position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription
complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a
group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal
transcription, serve as coactivators, function in promoter recognition or modify general transcription factors
(GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits
of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown
that this subunit is required for transcriptional activation by the estrogen receptor, for progression through
the cell cycle, and may also be required for certain cellular differentiation programs. (provided by RefSeq, Jul
2008)

GeneCards Summary for TAF10 Gene: 
TAF10 (TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with TAF10 include epidermodysplasia verruciformis, and progeria, and among its related super-pathways are Assembly of RNA Polymerase-II Initiation Complex and RNA Polymerase II Pre-transcription Events. GO annotations related to this gene include enzyme binding and sequence-specific DNA binding transcription factor activity.

UniProtKB/Swiss-Prot: TAF10_HUMAN, Q12962
Function: TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and
TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating
promoter responses to various activators and repressors

Gene Wiki entry for TAF10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TAF10 gene promoter:
         CRE-BP1   ATF-2   STAT3   ATF   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TAF10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAF10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.3   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.5-p15.2

TAF10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TAF10 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M006627:  view genomic region     (about GC identifiers)

Start:
6,627,526 bp from pter      End:
6,633,898 bp from pter
Size:
6,373 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TAF10_HUMAN, Q12962 (See protein sequence)
Recommended Name: Transcription initiation factor TFIID subunit 10  
Size: 218 amino acids; 21711 Da
Subunit: TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs).
TBP is not part of TFTC. Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, SUPT3H,
TAF5L TAF6L, TAF9, TAF10, TAF12 and TRRAP. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L,
TADA3L, SUPT3H, TAF2, TAF4, TAF5, GCN5L2/GCN5, TAF10 and TRRAP. Component of the STAGA transcription
coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12,
TRRAP and TAF9. The STAGA core complex is associated with a subcomplex required for histone deubiquitination
composed of ATXN7L3, ENY2 and USP22. Interacts with TAF3
Subcellular location: Nucleus
6/8 PDB 3D structures from and Proteopedia for TAF10 (see all 8):
3M53 (3D)        3M54 (3D)        3M55 (3D)        3M56 (3D)        3M57 (3D)        3M58 (3D)    
Secondary accessions: O00703 Q13175 Q6FH13

Explore the universe of human proteins at neXtProt for TAF10: NX_Q12962

Explore proteomics data for TAF10 at MOPED 

Post-translational modifications:

  • UniProtKB: Monomethylated at Lys-189 by SETD7, leading to increase its affinity for RNA polymerase II
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q12962

  • TAF10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TAF10 Protein Expression
    REFSEQ proteins: NP_006275.1  
    ENSEMBL proteins: 
     ENSP00000299424  
    Reactome Protein details: Q12962
    Human Recombinant Protein Products for TAF10: 
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    Cloud-Clone Corp. Proteins for TAF10 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000125PCAF complex IDA9674425
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005669transcription factor TFIID complex IDA14580349
    GO:0005737cytoplasm IDA15870280

    TAF10 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR003923 TFIID_30kDa

    Graphical View of Domain Structure for InterPro Entry Q12962

    ProtoNet protein and cluster: Q12962

    1 Blocks protein domain: IPB003923 Transcription initiation factor TFIID 23-30kDa subunit signature

    UniProtKB/Swiss-Prot: TAF10_HUMAN, Q12962
    Domain: The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase
    Similarity: Belongs to the TAF10 family


    TAF10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAF10_HUMAN, Q12962
    Function: TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and
    TBP-free TAFII complex (TFTC). TIIFD is a multimeric protein complex that plays a central role in mediating
    promoter responses to various activators and repressors

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700contributes to sequence-specific DNA binding transcription factor activity IDA9603525
    GO:0003713transcription coactivator activity IDA11564863
    GO:0004402contributes to histone acetyltransferase activity IDA11564863
    GO:0005515contributes to protein binding IPI15870280
    GO:0019899enzyme binding IPI16415881
         
    TAF10 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TAF10:
     Decreased TP53 protein express  Decreased viability  Increased cell death HMECs cel 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Taf10):
     cellular  embryogenesis  growth/size  homeostasis/metabolism  integument 
     mortality/aging 

    TAF10 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Taf10tm1.1Lzt for TAF10

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TAF10 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TAF10 About   (see all 14)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Assembly of RNA Polymerase-II Initiation Complex
    Assembly of RNA Polymerase-II Initiation Complex0.91
    Basal transcription factors0.50
    Transcription of mRNA0.91
    Crosstalk Between CARM1 and ESRs0.39
    Protein Acetylation and Deacetylation0.51
    2Formation of RNA Pol II elongation complex
    RNA Polymerase II Pre-transcription Events0.72
    RNA Polymerase II HIV Promoter Escape0.67
    Transcription of the HIV genome0.70
    RNA Polymerase II Transcription Pre-Initiation And Promoter Opening0.67
    RNA Polymerase II Transcription Initiation And Promoter Clearance0.67
    HIV Transcription Initiation0.67
    RNA Polymerase II Promoter Escape0.67
    RNA Polymerase II Transcription Initiation0.67
    3HIV Life Cycle
    HIV Life Cycle0.92
    HIV Infection0.61
    Late Phase of HIV Life Cycle0.92
    4Transcription
    Transcription0.69
    RNA Polymerase II Transcription0.69
    5Apoptotic Pathways in Synovial Fibroblasts
    Nuclear Receptor Activation by Vitamin-A0.57

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for TAF10
        Histone modification
    Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TAF10 (see all 7)
        Nuclear Receptor Activation by Vitamin-A
    Protein Acetylation and Deacetylation
    Assembly of RNA Polymerase-II Initiation Complex
    Glucocorticoid Receptor Signaling
    Estrogen Pathway

    1 GeneGo (Thomson Reuters) Pathway for TAF10
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    2 BioSystems Pathways for TAF10
        C-MYC pathway
    Validated targets of C-MYC transcriptional activation

    5/15        Reactome Pathways for TAF10 (see all 15)
        RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
    Late Phase of HIV Life Cycle
    RNA Polymerase II Transcription
    Transcription
    RNA Polymerase II Transcription Initiation And Promoter Clearance


    2         Kegg Pathways  (Kegg details for TAF10):
        Basal transcription factors
    Herpes simplex infection


    TAF10 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TAF10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/106 Interacting proteins for TAF10 (Q129621, 2, 3 ENSP000002994244) via UniProtKB, MINT, STRING, and/or I2D (see all 106)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FTLP027922, 3, ENSP000003665254MINT-63359 I2D: score=5 STRING: ENSP00000366525
    SETD7Q8WTS61, 3, ENSP000002740314EBI-708376,EBI-1268586 I2D: score=3 STRING: ENSP00000274031
    ATXN7O152651, 3, ENSP000003815904EBI-708376,EBI-708350 I2D: score=2 STRING: ENSP00000381590
    TAF9Q165943, ENSP000002178934I2D: score=2 STRING: ENSP00000370201 STRING: ENSP00000217893
    TBPP202263, ENSP000002303544I2D: score=5 STRING: ENSP00000230354
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006352DNA-dependent transcription, initiation IDA9212049
    GO:0006366transcription from RNA polymerase II promoter TAS--
    GO:0006367transcription initiation from RNA polymerase II promoter TAS--
    GO:0006368transcription elongation from RNA polymerase II promoter TAS--
    GO:0010467gene expression TAS--

    TAF10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TAF10

    Search CenterWatch for drugs/clinical trials and news about TAF10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TAF10 gene: 
    NM_006284.3  

    Unigene Cluster for TAF10:

    TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
    Hs.5158  [show with all ESTs]
    Unigene Representative Sequence: AL833496
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000526743 ENST00000299424(uc001mej.2) ENST00000527248 ENST00000531760
    ENST00000532344
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK310989.1 AL833496.1 BC012088.1 CR541943.1 U13991.1 

    19 DOTS entries:

    DT.112870  DT.95173144  DT.97802133  DT.449776  DT.120709447  DT.70101889  DT.100038213  DT.452885 
    DT.92447057  DT.92447059  DT.100886845  DT.120709302  DT.100886859  DT.120709507  DT.100886848  DT.100886863 
    DT.120709433  DT.95213307  DT.97855391 

    24/433 AceView cDNA sequences (see all 433):

    BF063406 CR597841 BM932304 BE842624 BX109502 BM984948 BM559236 AI468305 
    BQ653195 BF514923 BX417992 AW793578 Z45543 AI581795 AI800096 AI633781 
    AW469511 BM846123 CD369712 BM794929 BM762151 BE275619 AI289594 BE297102 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TAF10    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5
    SP1:                          -                                 
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            


    ECgene alternative splicing isoforms for TAF10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TAF10 expression in normal human tissues (normalized intensities)      TAF10 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCCCACACC
    TAF10 Expression
    About this image


    TAF10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Epiblast (Early Embryonic Tissues)    fully expand to see all 3 entries
             Intraembryonic Epiblast Cells Epiblast
             Epiblast

    See TAF10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TAF10

    SOURCE GeneReport for Unigene cluster: Hs.5158
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TAF10 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Taf101 , 5 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated more1, 5 90.67(n)1
    91.74(a)1
      7 (55.97 cM)5
    240751  NM_020024.31  NP_064408.21 
     1057393935 
    lizard
    (Anolis carolinensis)
    Reptilia TAF106
    Uncharacterized protein
    60(a)
    1 ↔ 1
    AAWZ02038015(7210-11181)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.238032 Xenopus laevis transcribed sequence with weak similarity more 79.33(n)    48029036 
    zebrafish
    (Danio rerio)
    Actinopterygii taf101 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated more 66.87(n)
    75.15(a)
      556710  NM_001044811.2  NP_001038276.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Taf10b3
    Taf101
    transcription initiation from Pol II
    promoter more3
    TBP-associated factor 101
    62(a)3
    63.64(n)1
    62.73(a)1
      23A53
    334691  NM_058115.41  NP_477463.11 
    worm
    (Caenorhabditis elegans)
    Secernentea taf-106
    Protein TAF-10, isoform b
    38(a)
    1 ↔ 1
    V(4687107-4688028)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TAF10(YDR167W)4 Subunit (145 kDa) of TFIID and SAGA complexes, involved more   --   4(789449-790069) 851745  NP_010451.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TAFII151 TBP-associated factor II 15 52.61(n)
    51.96(a)
      829300  NM_119321.3  NP_194900.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g04315001 hypothetical protein 52.72(n)
    49.65(a)
      4347127  NM_001069773.1  NP_001063238.1 


    ENSEMBL Gene Tree for TAF10 (if available)
    TreeFam Gene Tree for TAF10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TAF10 gene

    TAF10 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for TAF10
    PGOHUM00000239724 PGOHUM00000246067


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/30 SNPs in TAF10 are shown (see all 30)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1998568331,2
    --6632624(+) ATGCGG/TGGGTC 2 P syn10--------
    rs1908772771,2
    C--6632669(+) CCAGTC/GACTGC 2 V syn10--------
    rs18763001,2
    C,F,A,H--6632857(+) TTTTGA/TCAGCA 1 -- int120Minor allele frequency- T:0.47NS EA NA WA EU 4047
    rs1821514421,2
    C--6632874(+) GTGGCC/GTTGTT 1 -- int10--------
    rs1112694221,2
    C--6632894(+) GCCCAC/G/TCGTAG 1 -- spd11CSA 1
    rs2016842031,2
    --6632953(+) ACACCA/CCGGGC 2 G V mis10--------
    rs1503470331,2
    C,F--6632991(+) AGTACG/ATAAAC 2 /Y syn12Minor allele frequency- A:0.00NA EU 4511
    rs31763111,2,4
    C,F,H--6633007(-) GGCCAT/CATCTA 2 /T /I mis1 ese38Minor allele frequency- C:0.00NS EA NA EU 905
    rs2016567141,2
    --6633010(+) ATATGG/TCCCCC 2 D A mis10--------
    rs2012618901,2
    --6633090(+) GGAGGC/TGCAGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for TAF10 (6627526 - 6633898 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TAF10:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv996362CNV Deletion20482838
    nsv896972CNV Loss21882294
    nsv896971CNV Loss21882294
    nsv825755CNV Gain20364138

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    DNA2.0 Custom Variant and Variant Library Synthesis for TAF10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600475    OMIM disorders: --

    4 diseases for TAF10:    About MalaCards
    epidermodysplasia verruciformis    progeria    fanconi's anemia    anemia


    TAF10 for disorders           About GeneDecksing


    Export disorders for TAF10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TAF10 gene, integrated from 9 sources (see all 62):
    (articles sorted by number of sources associating them with TAF10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor. (PubMed id 7923369)1, 2, 3 Jacq X.... Tora L. (1994)
    2. Organization and chromosomal localization of the gene (TAF2H) encoding the human TBP-associated factor II 30 (TAFII30). (PubMed id 8530084)1, 2, 9 Scheer E.... Tora L. (1995)
    3. A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. (PubMed id 18206972)1, 2 Zhao Y.... Devys D. (2008)
    4. Structural basis for the methylation site specificity of SET7/9. (PubMed id 16415881)1, 2 Couture J.-F.... Trievel R.C. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Gene-specific modulation of TAF10 function by SET9-mediated methylation. (PubMed id 15099517)1, 2 Kouskouti A....Talianidis I. (2004)
    7. Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one- dimensional gel electrophoresis. (PubMed id 12601814)1, 2 Cavusoglu N.... van Dorsselaer A. (2003)
    8. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage- binding factors in vivo. (PubMed id 11564863)1, 2 Martinez E.... Roeder R.G. (2001)
    9. The TFIID components human TAFII140 and Drosophila BIP2 (TAFII155) are novel metazoan homologues of yeast TAFII47 containing a histone fold and a PHD finger. (PubMed id 11438666)1, 2 Gangloff Y.G.... Davidson I. (2001)
    10. Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction. (PubMed id 10373431)1, 2 Brand M.... Tora L. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 6881 HGNC: 11543 AceView: TAF10andKIAA0409 Ensembl:ENSG00000166337 euGenes: HUgn6881
    ECgene: TAF10 Kegg: 6881 H-InvDB: TAF10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TAF10 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TAF10 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/taf10/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TAF10 gene:
    Search GeneIP for patents involving TAF10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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