TAF1 Gene
protein-coding GIFtS: 68
GCID: GC0XP070586
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|
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated...(Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase...)
(Previous symbols: TAF2A, BA2R, CCG1, CCGS, DYT3)
| |
Aliases
for TAF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| TAF1 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor,250kDa1 2 | | TBP-Associated Factor 250 KDa2 3 | | BA2R1 2 3 5 | | EC 2.7.11.13 8 | | CCG11 2 3 5 | | Dystonia 3 (With Parkinsonism)1 | | TAF2A1 2 3 5 | | TATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase II, A, 250kD1 | | CCGS1 2 3 | | N-TAF12 | | TAFII2501 2 3 | | OF2 | | DYT31 2 5 | | P2502 | | DYT3/TAF11 2 | | XDP2 | | KAT41 2 | | Cell Cycle, G1 Phase Defect2 | | NSCL21 2 | | Complementation Of Cell Cycle Block, G1-To-S2 | | Cell Cycle Gene 1 Protein2 3 | | Transcription Factor TFIID P250 Polypeptide2 | | Transcription Initiation Factor TFIID 250 KDa Subunit2 3 | | Transcription Initiation Factor TFIID Subunit 12 | | TAF(II)2502 3 | | P2502 | | TAFII-2502 3 | | EC 2.7.118 |
Export aliases for TAF1 gene to outside databasesPrevious GC identifers: GC0XP066759 GC0XP068063 GC0XP068819 GC0XP069452 GC0XP070369 GC0XP070502 GC0XP064401 |
Summaries
for TAF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TAF1:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein thatcoordinates these activities is the basal transcription factor TFIID, which binds to the core promoter to position thepolymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as achannel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarilyconserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve ascoactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complexassembly and transcription initiation. This gene encodes the largest subunit of TFIID. This subunit binds to corepromoter sequences encompassing the transcription start site. It also binds to activators and other transcriptionalregulators, and these interactions affect the rate of transcription initiation. This subunit contains two independentprotein kinase domains at the N and C-terminals, but also possesses acetyltransferase activity and can act as aubiquitin-activating/conjugating enzyme. This gene is part of a complex transcriptional unit (TAF1/DYT3), wherein someproducts share exons with TAF1 as well as additional exons downstream.(provided by RefSeq, Aug 2009)
UniProtKB/Swiss-Prot: TAF1_HUMAN, P21675Function: Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- andC-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors.Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 onSer residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle
Gene Wiki entry for TAF1
|
Genomic Views
for TAF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_011669.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TAF1 gene promoter:
TBP TFIID MyoD
Other transcription factors
Search SABiosciences Chromatin IP Primers for TAF1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAF1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq13.1 Ensembl cytogenetic band: Xq13.1 HGNC cytogenetic band: Xq13.1TAF1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP070586: view genomic region
(about GC identifiers)
Start:
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70,586,114 bp from pter |
End:
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70,752,224 bp from pter |
Size:
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166,111 bases |
Orientation:
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plus strand |
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Proteins
for TAF1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TAF1_HUMAN, P21675 (See
protein sequence)Recommended Name: Transcription initiation factor TFIID subunit 1 Size: 1872 amino acids; 212677 Da
Cofactor: Magnesium
Subunit: TAF1 is the largest component of transcription factor TFIID that is composed of TBP and a variety ofTBP-associated factors. TAF1, when part of the TFIID complex, interacts with C-terminus of TP53. Component of someMLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as thefacultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20,PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. RB1 interacts with theN-terminal domain of TAF1. Interacts with ASF1A and ASF1B. Interacts with SV40 Large T antigen. Interacts (via bromodomains) with acetylated lysine residues on the N-terminus of histone H1.4, H2A, H2B, H3 and H4 (in vitro)
Subcellular location: Nucleus
4 PDB 3D structures from  and Proteopedia  for TAF1:1EQF (3D)
3AAD (3D)
3UV4 (3D)
3UV5 (3D)
Secondary accessions: A5CVD0 Q59FZ3 Q6IUZ1 Q70Q86 Q70Q87 Q70T00 Q70T01 Q70T02 Q70T03Alternative splicing: 4 isoforms: P21675-1 P21675-2 P21675-3 P21675-4 (Contains a phosphoserine at position 1700)Explore the universe of human proteins at neXtProt for TAF1: NX_P21675
Post-translational modifications:
Phosphorylated by casein kinase II in vitro1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P21675
4/22 DME Specific Peptides for TAF1 (P21675) (see all 22)
TAF1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_004597.2 NP_620278.1
ENSEMBL proteins: ENSP00000362895 ENSP00000276072 ENSP00000424526 ENSP00000421611 ENSP00000406517 ENSP00000362880 ENSP00000389000 ENSP00000406549 Reactome Protein details: P21675
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
TAF1 for ontologies About GeneDecksing
TAF1 Antibody Products:
Assay Products for TAF1: |
Protein
Domains /
Families
for TAF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TAF1 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P21675ProtoNet protein and cluster: P21675 1 Blocks protein family: IPB001487 Bromodomain signature
UniProtKB/Swiss-Prot: TAF1_HUMAN, P21675Similarity: Belongs to the TAF1 familySimilarity: Contains 2 bromo domainsSimilarity: Contains 1 HMG box DNA-binding domainSimilarity: Contains 2 protein kinase domains |
Function
for TAF1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TAF1_HUMAN, P21675Function: Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- andC-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors.Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 onSer residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycleCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Autophosphorylates on Ser residues. Inhibited by retinoblastoma tumor suppressor protein, RB1Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAF1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAF1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TAF1 (NM_138923) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAF1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAF1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF1 |
Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12): About this table
TAF1 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for TAF1:
|
Pathways & Interactions
for TAF1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Formation of RNA Pol II elongation complex | | | 2 | Assembly of RNA Polymerase-II Initiation Complex | | | 3 | HIV Infection | | | 4 | Late Phase of HIV Life Cycle | | | 5 | Transcription | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for TAF1
5/7 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for TAF1 (see all 7)
1  GeneGo (Thomson Reuters) Pathway for TAF1
1  BioSystems Pathway for TAF1
5/19 
Reactome Pathways for TAF1 (see all 19)
1 
Kegg Pathway (Kegg details for TAF1):
TAF1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TAF1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/138 Interacting proteins for TAF1 (P216751, 2, 3 ENSP000002760724) via UniProtKB, MINT, STRING, and/or I2D (see all 138)About this table
Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000080 | G1 phase of mitotic cell cycle |
IGI | 9660973 | | GO:0000117 | regulation of transcription involved in G2/M-phase of mitotic cell cycle |
ISS | -- | | GO:0006352 | DNA-dependent transcription, initiation |
ISS | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
-- | -- | | GO:0006366 | transcription from RNA polymerase II promoter |
TAS | -- |
TAF1 for ontologies About GeneDecksing
|
Drugs & Compounds
for TAF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TAF1 for compounds About GeneDecksing
 Browse Tocris compounds for TAF1
1 HMDB Compound for TAF1 About this table
6 Novoseek chemical compound relationships for TAF1 gene About this table
Search CenterWatch for drugs/clinical trials and news about TAF1
|
Transcripts
for TAF1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TAF1 gene (2 alternative transcripts): NM_004606.3 NM_138923.2 Unigene Cluster for TAF1: TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa Hs.158560 [show with all ESTs]Unigene Representative Sequence: NM_00460618/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21): ENST00000373790(uc004dzu.4) ENST00000276072(uc010nld.1) ENST00000483365
ENST00000472567 ENST00000478305 ENST00000474917 ENST00000483985 ENST00000463163
ENST00000437147(uc004dzx.2 uc004dzw.1) ENST00000373775(uc010nle.1 uc010nlf.1 uc004dzy.2)
ENST00000462588 ENST00000485087 ENST00000468167 ENST00000461764 ENST00000492404
ENST00000482544 ENST00000461157 ENST00000467309(uc010nlg.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAF1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAF1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TAF1 (NM_138923) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TAF1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAF1 |
Additional cDNA sequence: AB209316.1 AB300418.1 AJ549245.1 AJ549246.2 AJ549247.1 AJ549248.3 AJ549249.2 AJ549250.3 AJ555148.2 AJ555149.2 AK310201.1 AM711892.1 AM711893.1 AM711894.1 AM711895.1 D90359.1 M73444.1 X07024.1 14 DOTS entries: DT.100772930 DT.97839287 DT.208635 DT.100813411 DT.101981609 DT.101981607 DT.100813410 DT.101981606 DT.75107913 DT.91806256 DT.95269197 DT.91650549 DT.91847487 DT.121285810 24/109 AceView cDNA sequences (see all 109): NM_138923 BE466241 AI500610 AI275999 BQ027170 BQ950158 AJ549247 BQ436343 R66536 M73444 AI970464 BM463339 AI246039 D90359 NM_004606 BQ962632 BX437484 AJ549248 AW074202 AJ549250 AJ549246 AW613259 BX404867 BX279670
GeneLoc Exon Structure
|
Expression
for TAF1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TAF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGTTTATA
About this image
See TAF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TAF1
SOURCE GeneReport for Unigene cluster: Hs.158560
SABiosciences Custom PCR Arrays for TAF1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAF1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TAF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAF1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF1 |
Orthologs
for TAF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TAF1 gene from 8/28 species (see all 28) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TAF11 |
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated more |
79.79(n)
89.92(a) |
|
422204 XM_420198.3 XP_420198.3 |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
87(a) |
possible ortholog |
GL343599.1(27628-60414) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.148742 |
Xenopus laevis transcribed sequence with strong similarity more |
78.79(n) |
|
BJ060709.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufy39f072 |
wufy39f07 |
77.72(n) |
|
386861 57062714 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Taf11 , 3 |
transcription initiation from Pol II
promoter more3
TBP-associated factor 11 |
49(a)3
55.99(n)1
53.29(a)1 |
|
3 84A13
408131 NM_206438.21 NP_996160.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
taf-11 |
Protein TAF-1 |
50.63(n)
42.61(a) |
|
173257 NM_061025.3 NP_493426.2 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
HAF016TAF1B6 |
transcription initiation factor TFIID subunit 1-B |
18(a)17(a) |
many ↔ manymany ↔ many |
1(11846247-11856765) 3(6567157-6575282) |
rice
(Oryza sativa) |
Liliopsida |
-- |
transcription initiation factor TFIID subunit 1, p... |
19(a) |
1 → many |
6(26359284-26373493) |
ENSEMBL Gene Tree for TAF1 (if available)
TreeFam Gene Tree for TAF1 (if available) |
Paralogs
for TAF1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TAF1 gene
- TAF1L2
4 SIMAP similar genes for TAF1 using alignment to 6 protein entries: TAF1_HUMAN (see all proteins):DYT3 N-TAF1 TAF1L BRDT
TAF1 for paralogs About GeneDecksing
|
Genomic Variants
for TAF1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TAF1 (70586114 - 70752224 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TAF1
1 CNV: 7797
Human Gene Mutation Database (HGMD): TAF1
Locus Specific Mutation Databases (LSDB): TAF1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAF1 |
|
Disorders
/ Diseases
for TAF1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TAF1 for disorders About GeneDecksing
OMIM gene information: 313650
OMIM disorders: 314250
UniProtKB/Swiss-Prot: TAF1_HUMAN, P21675
Defects in TAF1 are the cause of dystonia type 3 (DYT3) [MIM:314250]; also called X-linkeddystonia-parkinsonism (XDP). DYT3 is a X-linked dystonia-parkinsonism disorder. Dystonia is defined by the presence ofsustained involuntary muscle contractions, often leading to abnormal postures. DYT3 is characterized by severeprogressive torsion dystonia followed by parkinsonism. Its prevalence is high in the Philippines. DYT3 has awell-defined pathology of extensive neuronal loss and mosaic gliosis in the striatum (caudate nucleus and putamen)which appears to resemble that in Huntington disease
20/21  diseases for TAF1 (see all 21): About MalaCardsx-linked dystonia-parkinsonism disseminated intravascular coagulation spinocerebellar ataxia type 17 torsion dystonia
spinocerebellar ataxia hyperprothrombinemia familial dystonia pulmonary embolism
coronary heart disease ankylosis myocardial infarction gliosis
ataxia retinoblastoma huntington's disease thrombosis
breast cancer cerebritis immunodeficiency neuronitis
3 diseases from the University of Copenhagen DISEASES database for TAF1:Disseminated intravascular coagulation Familial dystonia Movement disease 3 Novoseek disease relationships for TAF1 gene About this table
GeneTests: TAF1
X-Linked Dystonia-Parkinsonism Syndrome
Genetic Association Database (GAD): TAF1
Human Genome Epidemiology (HuGE) Navigator: TAF1 (15 documents)
Export disorders for TAF1 gene to outside databases
|
Publications
for TAF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TAF1 gene, integrated from 9 sources (see all 194):
(articles sorted by number of sources associating them with TAF1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Specific sequence changes in multiple transcript system DYT3 are associated with X-linked dystonia parkinsonism. (PubMed id 12928496)1, 2, 3, 9 Nolte D.... Muller U. (2003)
- Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression. (PubMed id 15053879)1, 2, 9 Li H.-H.... Liu X. (2004)
- Rb inhibits the intrinsic kinase activity of TATA-binding protein- associated factor TAFII250. (PubMed id 9858607)1, 2, 9 Siegert J.L. and Robbins P.D. (1999)
- Reduced neuron-specific expression of the TAF1 gene is associated with X-linked dystonia-parkinsonism. (PubMed id 17273961)1, 2, 9 Makino S.... Tamiya G. (2007)
- Taf(II) 250 phosphorylates human transcription factor IIA on serine residues important for TBP binding and transcription activity. (PubMed id 11278496)1, 2, 9 Solow S.... Lieberman P.M. (2001)
- TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74. (PubMed id 8625415)1, 2, 9 Dikstein R.... Tjian R. (1996)
- The human CCG1 gene, essential for progression of the G1 phase, encodes a 210-kilodalton nuclear DNA-binding protein. (PubMed id 2038334)1, 2, 9 Sekiguchi T.... Nishimoto T. (1991)
- Structural and functional analysis of the human TAF1/DYT3 multiple transcript system. (PubMed id 17952504)1, 3, 9 Herzfeld T....Muller U. (2007)
- Cloning and expression of human TAFII250: a TBP-associated factor implicated in cell-cycle regulation. (PubMed id 7680771)1, 2, 9 Ruppert S.... Tjian R. (1993)
- Functional analysis of the human TAFII250 N-terminal kinase domain. (PubMed id 9660973)1, 2, 9 O'Brien T. and Tjian R. (1998)
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External Searches for TAF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing TAF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing TAF1 gene
(According to HUGE)
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Specialized Databases showing TAF1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for TAF1 | Pharmacogenomics, SNPs, Pathways | | NIEHS-SNPs | http://egp.gs.washington.edu/data/taf1/ |
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| Patent Information for TAF1 gene:
Search GeneIP for patents involving TAF1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TAF1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TAF1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TAF1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TAF1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TAF1 | | OriGene 3'-UTR Clone for TAF1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TAF1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TAF1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TAF1 | | OriGene Custom Protein Services for TAF1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TAF1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TAF1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TAF1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TAF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TAF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TAF1 |
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| | | | Search Tocris compounds for TAF1 |
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 | | | TAF1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TAF1 |
|  |  |  | | | | ThermoFisher Antibodies for TAF1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TAF1 |
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