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TAF1 Gene

protein-coding GIFtS: 68

GC0XP070502

TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
(Previous names: TATA box binding protein (TBP)-associated factor, RNA polymerase II, A, 250kD )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: TAF2A, BA2R, CCG1, CCGS)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BA2R ^², ³, ⁵
CCG1 ^², ³, ⁵
CCGS ^², ³
DYT3 ^², ⁵
EC 2.7.11.1 ^³
KAT4 ^¹, ²
N-TAF1 ^²
NSCL2 ^¹, ²
OF ^²
OTTHUMP00000024334 ^²
P250 ^²
TAF(II)250 ^³
TAF2A ^², ³, ⁵
TAFII-250 ^³
TAFII250 ^¹, ², ³
p250 ^³

Descriptions
Cell cycle gene 1 protein ^³
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa ^²
TAF1 RNA polymerase II, TATA box binding protein-associated factor, 250kDa ^¹
TATA box binding protein (TBP)-associated factor, RNA polymerase II, A, 250kD ^¹
TBP-associated factor 1 ^²
TBP-associated factor 250 kDa ^³
Transcription initiation factor TFIID 250 kDa subunit ^³
cell cycle, G1 phase defect ^²
complementation of cell cycle block, G1-to-S ^²
transcription factor TFIID p250 polypeptide ^²

External Ids
HGNC: 11535¹
Entrez Gene: 6872²
UniProtKB: P21675³
Ensembl: ENSG00000147133⁷

Search outside databases for aliases for TAF1 gene

Previous GC identifers: GC0XP066759 GC0XP068063 GC0XP068819 GC0XP069452 GC0XP070369

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TAF1:

Initiation of transcription by RNA polymerase II requires the activities of more than 70

polypeptides. The protein that coordinates these activities is the basal transcription factor

TFIID, which binds to the core promoter to position the polymerase properly, serves as the

scaffold for assembly of the remainder of the transcription complex, and acts as a channel for

regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of

evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in

basal transcription, serve as coactivators, function in promoter recognition or modify general

transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This

gene encodes the largest subunit of TFIID. This subunit binds to core promoter sequences

encompassing the transcription start site. It also binds to activators and other transcriptional

regulators, and these interactions affect the rate of transcription initiation. This subunit

contains two independent protein kinase domains at the N and C-terminals, but also possesses

acetyltransferase activity and can act as a ubiquitin-activating/conjugating enzyme. Two

transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: TAF1_HUMAN, P21675

Function: Largest component and core scaffold of the TFIID basal transcription factor complex.

Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or

transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to

MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses

DNA-binding activity. Essential for progression of the G1 phase of the cell cycle

Gene Wiki entry for TAF1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the TAF1 gene

Entrez Gene cytogenetic band: Xq13.1 Ensembl cytogenetic band: Xq13.1 HGNC cytogenetic band: Xq13.1

TAF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP070502: (about GC identifiers)

Start:	70,502,839 bp from pter
End:	70,601,025 bp from pter
Size:	98,187 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000023.9 NT_011669.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TAF1_HUMAN, P21675 (See protein sequence)

Recommended Name: Transcription initiation factor TFIID subunit 1

Size: 1872 amino acids; 212677 Da

Cofactor: Magnesium

Subunit: TAF1 is the largest component of transcription factor TFIID that is composed of TBP and a

variety of TBP-associated factors. TAF1, when part of the TFIID complex, interacts with C-terminus

of TP53. RB1 interacts with the N-terminal domain of TAF1. Interacts with ASF1A and ASF1B.

Interacts with SV40 Large T antigen

Subcellular location: Nucleus

PDB structures from and Proteopedia :

1EQF (3D)

Secondary accessions: A5CVD0 Q59FZ3 Q6IUZ1 Q70Q86 Q70Q87 Q70T00 Q70T01 Q70T02 Q70T03

Alternative splicing: 4 isoforms: P21675-1 P21675-2 P21675-3 P21675-4

Post-translational modifications:

Phosphorylated by casein kinase II in vitro¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_004597.2 NP_620278.1

ENSEMBL proteins:

ENSP00000362895 ENSP00000276072 ENSP00000379125

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich AQUA Peptides for TAF1
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (KAT4 / TBP Associated Factor 1)
	Human Recombinant Proteins from Abnova (TAF1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	TAS	7680771
GO:0005654	nucleoplasm	EXP	1939271 2449431 8946909
GO:0005669	transcription factor TFIID complex	TAS	7680771
GO:0005730	NOT nucleolus	IDA	18029348

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Antibodies for TAF1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for TAF1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (KAT4 / TBP Associated Factor 1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (TAF1)
	Novus Biologicals Antibodies for TAF1

Assays for TAF1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P21675

ProtoNet protein and cluster: P21675

1 Blocks protein family: IPB001487 Bromodomain signature

UniProtKB/Swiss-Prot: TAF1_HUMAN, P21675

Similarity: Belongs to the TAF1 family

Similarity: Contains 2 bromo domains

Similarity: Contains 1 HMG box DNA-binding domain

Similarity: Contains 2 protein kinase domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TAF1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TAF1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_004606

Applied Biosystems Silencer® siRNAs for TAF1

Sigma-Aldrich siRNA and siRNA Panels for TAF1

Sigma-Aldrich shRNA Panels and shRNA for TAF1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for TAF1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004606
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004606
untagged cDNA clones in CMV expression vector (see all 2): NM_004606

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004606

UniProtKB/Swiss-Prot: TAF1_HUMAN, P21675

Function: Largest component and core scaffold of the TFIID basal transcription factor complex.

Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or

transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to

MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses

DNA-binding activity. Essential for progression of the G1 phase of the cell cycle

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme regulation: Autophosphorylates on Ser residues. Inhibited by retinoblastoma tumor suppressor

protein, RB1

Enzyme Number (IUBMB): EC 2.7.11.1

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003677	DNA binding	IEA	--
GO:0004402	histone acetyltransferase activity	IDA	8980232
GO:0004674	protein serine/threonine kinase activity	IDA	8625415
GO:0005515	protein binding	IPI	7590250 7680771 9858607

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for TAF1 (Your Favorite Gene powered by Ingenuity)

Estrogen Receptor Signaling
Glucocorticoid Receptor Signaling

GeneDecks TAF1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for TAF1

5/110 Interacting proteins for TAF1 (ENSP00000276072³ P21675^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 110 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RB1	P06400¹	STRING (score=.998) EBI-491289, EBI-491274
TBP	P20226¹^,²	STRING (score=.999) EBI-491289, EBI-355371 MINT-72607 EBI-491289, EBI-355371 MINT-72607
GTF2F1	P35269¹	EBI-491289, EBI-457886
E2 E2 (xeno)	P03120¹	EBI-491313, EBI-1779322
TBP	P20226¹^,²	STRING (score=.999) EBI-491289, EBI-355371 MINT-72607 EBI-491289, EBI-355371 MINT-72607

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5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000080	G1 phase of mitotic cell cycle	TAS	7680771
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0006367	transcription initiation from RNA polymerase II promoter	EXP	8946909
GO:0006368	RNA elongation from RNA polymerase II promoter	EXP	9405375

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TAF1
3 Novoseek chemical compound relationships for TAF1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
lysine	32.43	6	11686293 (1), 17996705 (1)
proline	10.18	2	2038334 (1), 7892648 (1)
polyacrylamide	4.68	1	9188471 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (TAF1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (TAF1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_004606

Sigma-Aldrich siRNA and siRNA Panels for TAF1

Sigma-Aldrich shRNA Panels and shRNA for TAF1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004606 NM_138923

REFSEQ mRNAs for TAF1 gene (2 alternative transcripts):

NM_004606.3 NM_138923.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004606 NM_138923

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_004606
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_004606
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004606

Additional cDNA sequence:

AB209316.1 AB300418.1 AF149724.1 AJ549245.1 AJ549246.1 AJ549247.1 AJ549248.3 AJ549249.2

AJ549250.3 AJ555148.2 AJ555149.2 AK310201.1 AM711892.1 AM711893.1 AM711894.1 AM711895.1

BC101123.1 BC101124.1 BC117297.1 D90359.1 M73444.1 X07024.1

14 DOTS entries:

DT.100772930 DT.97839287 DT.208635 DT.91806256 DT.100813411 DT.101981609 DT.101981607 DT.100813410

DT.101981606 DT.75107913 DT.95269197 DT.121285810 DT.91650549 DT.91847487

24/109 AceView cDNA sequences (see all 109 ):

AJ549248 BX437484 BE466241 BM463339 BX279670 AJ549245 AI246039 NM_004606

AJ549247 AW074202 BX404867 NM_138923 AI500610 AJ549250 R66536 BG289819

BQ027170 AJ549249 BQ436343 M73444 BQ962632 AW613259 AI275999 AI970464

highest scoring ESTs for TAF1:

D90359 AA677306 AA835778 AI970464 AJ549245 AJ549246 AJ549247 AJ549248 AJ549249 AJ549250

Unigene Cluster for TAF1:

TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa

Hs.158560 [show with all ESTs]

Unigene Representative Sequence: NM_004606

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000373790 ENST00000276072 ENST00000395779

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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TAF1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for TAF1

¹ / ² / ³

10 probe-sets matching TAF1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37491_at²^{, 3}	U95-A	1	1.00	1.00	0.10	1.02	D90359	1.00	1.00	1.00	1
154_at²^{, 3}	U95-A	1	1.00	1.00	0.82	0.40	X07024	0.60	0.83	0.73	1
62571_at²^{, 3}	U95-C	2	1.00	0.97	0.64	1.66	AI970464	0.80	1.00	0.91	1
112_g_at²^{, 3}	U95-A	2	1.00	0.53	-0.14	0.45	X07024	0.60	0.83	0.73	1
227205_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AW575233	0.60	1.00	0.82	1
216955_at²^{, 3}	U133-A	1	1.00	1.00	--	--	X07024	0.60	0.83	0.73	1
216711_s_at²^{, 3}	U133-A	3	1.00	0.80	--	--	M73444	0.60	1.00	0.82	1
227205_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
216955_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
216711_s_at²	U133Plus2	3	1.00	0.80	--	--	--	--	--	--	--

GeneDecks TAF1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGTGTTTATA

SOURCE GeneReport for Unigene cluster: Hs.158560
Expression variation in blood from EXPOLDB for TAF1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for TAF1 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	TAF1¹	--	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated more	93.89(n) 98.04(a)	491950 XM_549070.2 XP_549070.2
cow (Bos taurus)	TAF1¹	--	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated more	94.18(n) 98.04(a)	504792 XM_580963.3 XP_580963.3
rat (Rattus norvegicus)	Taf1¹	--	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated more	91.26(n) 96.4(a)	317256 XM_228551.4 XP_228551.3
mouse (Mus musculus)	Taf1^{1, 5}	X (38.00 cM)⁵	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated more^{1, 5}	90.87(n)¹ 95.72(a)¹	270627¹ NM_001081008.1¹ NP_001074477.1¹ AB299229⁵ AF022178⁵ (see all 24)
zebrafish (Danio rerio)	wufy39f07²	--	wufy39f07	77.72(n)	386861 57062714

About this table Species with no ortholog for TAF1

ENSEMBL Gene Tree for TAF1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for TAF1 gene

TAF1L²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/243 NCBI SNPs in TAF1 are shown (see all 243 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 81)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs10521350^1,2	C,F,H	70602110(+)	`TAATGT/CGGTTT`	2	--	ut3¹		12	NS EU EA WA NA	645
--	rs7055342^1,2	A,C,F	70502785(+)	`TCCCCA/CCTTCC`	2	--	ng5¹		1	NS	180
--	rs5981105^1,2	A,C,F	70501715(+)	`gggtgT/Gtggct`	2	--	ng5¹		1	NS	154
--	rs28382158^1,2	C,F	70514271(+)	`GTGAGC/GTGATA`	2	L/V	mis¹		7	NS	804
	rs7053847^1,2	F,H	70501677(+)	`TATTAT/CCATAA`	2	--	ng5¹		4	EU EA WA	418
	rs6625784^1,2	H	70519366(+)	`ATCCAT/GGGAAT`	2	G/W	mis¹ ese³		4	EU EA WA	418
	rs5981106^1,2	C,F,H	70511857(+)	`ATTACT/CGGTGG`	2	T/T	syn¹ ese³		5	EU EA WA NA	496
	rs7050748^1,2	A,C,F	70544202(+)	`CTGTCG/ATCCAT`	2	S/S	syn¹ ese³		5	NA NS	365
--	rs28382162^1,2	F	70518430(+)	`CAGGCC/GATGCC`	2	A/A	syn¹		1	NS	180
--	rs4844148^1,2	A,C,F,H	70546047(+)	`TGCATG/ATAAAG`	2	--	int¹		11	EU EA WA NS	1256

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HapMap Linkage Disequilibrium images for TAF1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 313650 disorders: 314250

UniProtKB/Swiss-Prot: TAF1_HUMAN, P21675

Defects in TAF1 are the cause of dystonia type 3 (DYT3) [MIM:314250]; also called X-linked

dystonia-parkinsonism (XDP). DYT3 is a X-linked dystonia-parkinsonism disorder. Dystonia is

defined by the presence of sustained involuntary muscle contractions, often leading to abnormal

postures. DYT3 is characterized by severe progressive torsion dystonia followed by parkinsonism.

Its prevalence is high in the Philippines. DYT3 has a well-defined pathology of extensive neuronal

loss and mosaic gliosis in the striatum (caudate nucleus and putamen) which appears to resemble

that in Huntington disease

3 Novoseek disease relationships for TAF1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
retinoblastoma	42.06	6	9858607 (1), 9242374 (1), 11278496 (1)
cancer	0.00	1	11437234 (1)
tumors	0.00	4	9858607 (1), 9242374 (1), 11278496 (1)

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GeneTests: TAF1

X-Linked Dystonia-Parkinsonism Syndrome

Human Gene Mutation Database: TAF1
Genetic Association Database: TAF1
Human Genome Epidemiology Navigator: TAF1 (15 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/152 PubMed articles for TAF1 gene (see all 152 ):

Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression. (PubMed id 15053879)^{1, 3, 4} Li H.-H.... Liu X. (2004)
Rb inhibits the intrinsic kinase activity of TATA-binding protein- associated factor TAFII250. (PubMed id 9858607)^{1, 3, 4} Siegert J.L. and Robbins P.D. (1999)
Reduced neuron-specific expression of the TAF1 gene is associated with X-linked dystonia-parkinsonism. (PubMed id 17273961)^{1, 3, 4} Makino S.... Tamiya G. (2007)
Taf(II) 250 phosphorylates human transcription factor IIA on serine residues important for TBP binding and transcription activity. (PubMed id 11278496)^{1, 3, 4} Solow S.... Lieberman P.M. (2001)
TAFII250 is a bipartite protein kinase that phosphorylates the base transcription factor RAP74. (PubMed id 8625415)^{1, 3, 4} Dikstein R.... Tjian R. (1996)
The human CCG1 gene, essential for progression of the G1 phase, encodes a 210-kilodalton nuclear DNA-binding protein. (PubMed id 2038334)^{1, 3, 4} Sekiguchi T.... Nishimoto T. (1991)
Cloning and expression of human TAFII250: a TBP-associated factor implicated in cell-cycle regulation. (PubMed id 7680771)^{1, 3, 4} Ruppert S.... Tjian R. (1993)
Functional analysis of the human TAFII250 N-terminal kinase domain. (PubMed id 9660973)^{1, 3, 4} O'Brien T. and Tjian R. (1998)
Specific sequence changes in multiple transcript system DYT3 are associated with X-linked dystonia parkinsonism. (PubMed id 12928496)^{1, 3, 4} Nolte D.... Muller U. (2003)
Risk of cerebral venous thrombosis and novel gene polymorphisms of the coagulation and fibrinolytic systems. (PubMed id 16155788)^{3, 6} Lichy C....Grau A. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 6872	HGNC: 11535	AceView: TAF1	Ensembl:ENSG00000147133	euGenes: HUgn6872
ECgene: TAF1	H-InvDB: TAF1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
NIEHS-SNPs	http://egp.gs.washington.edu/data/taf1/

Licensable Technologies for TAF1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for TAF1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for TAF1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for TAF1		Antibodies for TAF1
	Explore super-pooled esiRNAs		Proteins for TAF1
	Lentivirus-delivered shRNAs for TAF1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (TAF1)
	Antibodies (TAF1)
	Chimera RNAi (TAF1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (KAT4 / TBP Associated Factor 1)
	Antibodies (KAT4 / TBP Associated Factor 1)

Search OriGene for TAF1

Search Tocris compounds for TAF1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for TAF1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
TAF1 Gene at Home site.
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TAF1 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for TAF1

Summaries
for TAF1

Genomic Location
for TAF1

Proteins
for TAF1

Protein Domains/
Families
for TAF1

Gene Function
for TAF1

Pathways & Interactions
for TAF1

Drugs & Compounds
for TAF1

Transcripts
for TAF1

Expression
for TAF1

Orthologs
for TAF1

Paralogs
for TAF1

SNPs/Variants
for TAF1

Disorders & Mutations
for TAF1

Medical News
for TAF1

Publications
for TAF1

Search for TAF1

Genome Databases showing TAF1

Other Databases showing TAF1

Specialized Databases showing TAF1

Licensable Technologies
for TAF1

Services
for TAF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

TAF1 (Gene Symbol)
BA2R
CCG1
CCGS
DYT3
EC 2.7.11.1
KAT4
N-TAF1
NSCL2
OF
OTTHUMP00000024334
P250
TAF(II)250
TAF2A
TAFII-250
TAFII250
p250
Cell cycle gene 1 protein
TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TAF1 RNA polymerase II, TATA box binding protein-associated factor, 250kDa
TATA box binding protein (TBP)-associated factor, RNA polymerase II, A, 250kD
TBP-associated factor 1
TBP-associated factor 250 kDa
Transcription initiation factor TFIID 250 kDa subunit
cell cycle, G1 phase defect
complementation of cell cycle block, G1-to-S
transcription factor TFIID p250 polypeptide

TAF1 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor TAF1

Summariesfor TAF1

Genomic Locationfor TAF1

Proteinsfor TAF1

Protein Domains/Familiesfor TAF1

Gene Functionfor TAF1

Pathways & Interactionsfor TAF1

Drugs & Compoundsfor TAF1

Transcriptsfor TAF1

Expression for TAF1

Orthologsfor TAF1

Paralogsfor TAF1

SNPs/Variantsfor TAF1

Disorders & Mutationsfor TAF1

Medical Newsfor TAF1

Publicationsfor TAF1

Search for TAF1

Genome Databases showing TAF1

Other Databases showing TAF1

Specialized Databases showing TAF1

Licensable Technologiesfor TAF1

Servicesfor TAF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for TAF1

Summaries
for TAF1

Genomic Location
for TAF1

Proteins
for TAF1

Protein Domains/
Families
for TAF1

Gene Function
for TAF1

Pathways & Interactions
for TAF1

Drugs & Compounds
for TAF1

Transcripts
for TAF1

Expression
for TAF1

Orthologs
for TAF1

Paralogs
for TAF1

SNPs/Variants
for TAF1

Disorders & Mutations
for TAF1

Medical News
for TAF1

Publications
for TAF1

Licensable Technologies
for TAF1

Services
for TAF1