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Aliases & Descriptions for TADA3L
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases ADA3 1 , 2 , 3 , 5 FLJ20221 1 , 2 FLJ21329 1 , 2 STAF54 3 hADA3 2 , 3
Descriptions ADA3 homolog 3 ADA3-like protein 3 transcriptional adaptor 3 (NGG1 homolog, yeast)-like 2 transcriptional adaptor 3-like 2
Search outside databases for aliases for TADA3L genePrevious GC identifer: GC03M009750
Summaries for TADA3L (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
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EntrezGene summary for TADA3L : Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymeraseII-mediated gene transcription by interacting functionally with the general transcriptionmachinery bound at the basal promoter. Adaptor proteins are usually required for this activation,possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at thepromoter. The protein encoded by this gene is a transcriptional activator adaptor and has beenfound to be part of the PCAF histone acetylase complex. In addition, it associates with the tumorsuppressor protein p53 and is required for full activity of p53 and p53-mediated apoptosis. Atleast four alternatively spliced variants have been found for this gene, but the full-lengthnature of some variants has not been determined. [provided by RefSeq] UniProtKB/Swiss-Prot: TAD3L_HUMAN, O75528 Function : Functions as a component of the PCAF complex. The PCAF complex is capable of efficientlyacetylating histones in a nucleosomal context. The PCAF complex could be considered as the humanversion of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependenttranscriptional activation
Gene Wiki entry for TADA3L
Genomic Location for TADA3L
(According to
GeneLoc and/or
HGNC , and/or
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and/or miRBase ,
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the TADA3L gene Entrez Gene cytogenetic band: 3p25.3 Ensembl cytogenetic band: 3p25.3 HGNC cytogenetic band: 3p25.3 TADA3L Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03M009796:
(about GC identifiers )
Start:
9,796,651 bp from pter
End:
9,809,420 bp from pter
Size:
12,770 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000003.10 NT_022517.17 Proteins for TADA3L
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
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Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
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UniProtKB/Swiss-Prot: TAD3L_HUMAN, O75528 (See
protein sequence )Recommended Name: Transcriptional adapter 3-like Size : 432 amino acids; 48902 Da
Subunit : The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5,TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such asTADA2L/ADA2, TADA3L/ADA3 and SPT3. Interacts directly with TADA2L and PCAF and also with thehigh-risk HPV oncoprotein E6. Component of the STAGA transcription coactivator-HAT complex, atleast composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP andTAF9. Component of the TFTC-HAT complex
Subcellular location : Nucleus
Secondary accessions : Q9UFS2Alternative splicing : 2 isoforms : O75528-1 O75528-2
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_006345.1 NP_597814.1 ENSEMBL proteins: ENSP00000343649 ENSP00000307684 Human Recombinant Proteins                OriGene Purified Recombinant Human Proteins (see all 2 ): TADA3L 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for TADA3L: Assays for TADA3L:
Protein
Domains/ Families for TADA3L(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry O75528 ProtoNet protein and cluster: O75528
UniProtKB/Swiss-Prot: TAD3L_HUMAN, O75528 Similarity : Belongs to the NGG1 family
Gene Function for TADA3L
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_006354 Applied Biosystems Silencer ® siRNAs for TADA3L Sigma-Aldrich siRNA for TADA3L Sigma-Aldrich shRNA for TADA3L Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_006354                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_006354                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_006354  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006354 UniProtKB/Swiss-Prot: TAD3L_HUMAN, O75528 Function : Functions as a component of the PCAF complex. The PCAF complex is capable of efficientlyacetylating histones in a nucleosomal context. The PCAF complex could be considered as the humanversion of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependenttranscriptional activation
2 Gene Ontology (GO) molecular function terms (links to tree view) :
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Pathways & Interactions for TADA3L
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(maps by GeneGo ),
Millipore ,
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Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for TADA3L 5/14 Interacting proteins for TADA3L (O75528 1 , 2 ) via UniProtKB, MINT, and/or STRING (see all 14
)Interactant Interaction Details GeneCard External ID(s) PIAS4 Q8N2W9 1 , 2 EBI-473249, EBI-473160 MINT-3979381 MINT-3981642 EBI-473249, EBI-473160 MINT-3979381 MINT-3981642 USP5 P45974 1 , 2 EBI-473249, EBI-741277 MINT-68333 EBI-473249, EBI-741277 MINT-68333 PIAS4 Q8N2W9 1 , 2 EBI-473249, EBI-473160 MINT-3979381 MINT-3981642 EBI-473249, EBI-473160 MINT-3979381 MINT-3981642 USP5 P45974 1 , 2 EBI-473249, EBI-741277 MINT-68333 EBI-473249, EBI-741277 MINT-68333 ADPGK Q9BRR6 2 MINT-63211
About this table 2 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006350 transcription
IEA -- GO:0006357 regulation of transcription from RNA polymerase II promoter
TAS 9674425
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_006354 Sigma-Aldrich siRNA for TADA3L Sigma-Aldrich shRNA for TADA3L Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_006354 NM_133480
REFSEQ mRNAs for TADA3L gene (2 alternative transcripts): NM_006354.2 NM_133480.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006354 NM_133480
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_006354                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_006354                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_006354  
Additional cDNA sequence: AF069733.1 AK000228.1 AK024982.1 AK292264.1 BC001480.2 BC009240.2 BC013433.1 CR533543.1 CR594013.1 CR597436.1 CR602056.1 CR607832.1 CR618353.1 CR620907.1 CR625213.1
19 DOTS entries : DT.416860 DT.100839926 DT.100839921 DT.100839923 DT.92024454 DT.100031477 DT.99993097 DT.100839925 DT.120858226 DT.120858314 DT.100839909 DT.100839917 DT.95267308 DT.100839913 DT.100839920 DT.40252140 DT.95267313 DT.100656916 DT.40120060
24/647 AceView cDNA sequences (see all 647
):BM670986 CD370744 AI333405 AL560299 AL117487 BQ277682 AI288787 AA465691 AK000228 AL514656 BM664000 BQ772392 AI084106 BM761658 BU150519 CR618353 CR533543 BE279559 BI772076 BG171754 BM983026 BE018320 AA365983 BX445719
highest scoring ESTs for TADA3L :AA171866 AA309897 AF069733 AK000228 AL514630 AL536378 AL547892 AL557621 BC001480 BC009240
Unigene Cluster for TADA3L: Transcriptional adaptor 3 (NGG1 homolog, yeast)-like Hs.386390 [show with all ESTs ] Unigene Representative Sequence: BC009240 GeneLoc Exon Structure 5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TADA3L (see all 8
) ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b SP1 :                             -                   SP2 :                             -     -   -             SP3 :       -   -                                       SP4 :                                               SP5 :   -   -   -   -   -                                    
About this scheme ECgene alternative splicing isoforms for TADA3L 2 Ensembl transcripts including schematic representations : ENST00000343450
ENST00000301964
Expression for TADA3L
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
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SOURCE , and/or
GNF
BioGPS , and/or
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UniProtKB ,
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TADA3L expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for TADA3L 1 / 2 / 3
5 probe-sets matching TADA3L gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GCTGCCCGGCSOURCE GeneReport for Unigene cluster: Hs.386390 Expression variation in blood from EXPOLDB for TADA3L
UniProtKB/Swiss-Prot: TAD3L_HUMAN, O75528 Tissue specificity : Ubiquitously expressed
Orthologs for TADA3L
(Orthologs according to
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3 euGenes ,
4 SGD
and/or
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Orthologs for TADA3L gene from 5/11 species (see all 11
)
About this table Species with no ortholog for TADA3L ENSEMBL Gene Tree for TADA3L Paralogs for TADA3L (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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SNPs/Variants for TADA3L (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for TADA3L (up to first 250kb)
Disorders & Mutations for TADA3L
(in which this Gene is Involved, According to
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OMIM: 602945
Medical News for TADA3L (Possibly Related Articles in
Doctor's Guide )
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Publications for TADA3L (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
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3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
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10/33 PubMed articles for TADA3L gene (see all 33
): hADA3 is required for p53 activity. (PubMed id 11707411) 2, 3, 4 Wang T....Brachmann R.K. (2001) Histone-like TAFs within the PCAF histone acetylase complex. (PubMed id 9674425) 2, 3, 4 Ogryzko V.V.... Nakatani Y. (1998) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) Human papillomavirus oncoprotein E6 inactivates the transcriptional coactivator human ADA3. (PubMed id 12138191) 3, 4 Kumar A.... Band V. (2002) Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. (PubMed id 11564863) 3, 4 Martinez E....Roeder R.G. (2001) Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166) 3, 4 Wiemann S.... Poustka A. (2001) The TAFs in the HAT. (PubMed id 9674419) 3, 4 Struhl K. and Moqtaderi Z. (1998) Human ADA3 binds to estrogen receptor (ER) and functions as a coactivator for ER-mediated transactivation. (PubMed id 15496419) 1, 3 Meng G....Band V. (2004) HPV16 E6-induced and E6AP-dependent inhibition of the transcriptional coactivator hADA3 in human cervical carcinoma cells. (PubMed id 19194825) 1, 3 Hu Y....Xie X. (2009)
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