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Aliases for TADA3 Gene

Aliases for TADA3 Gene

  • Transcriptional Adaptor 3 2 3
  • TADA3L 3 4 6
  • ADA3 3 4 6
  • ADA3-Like Protein 3 4
  • ADA3 Homolog 3 4
  • STAF54 3 4
  • HADA3 3 4
  • Transcriptional Adaptor 3 (NGG1 Homolog, Yeast)-Like 2
  • Transcriptional Adapter 3-Like 4
  • Transcriptional Adapter 3 3
  • NGG1 3

External Ids for TADA3 Gene

Previous Symbols for TADA3 Gene

  • TADA3L

Summaries for TADA3 Gene

Entrez Gene Summary for TADA3 Gene

  • DNA-binding transcriptional activator proteins increase the rate of transcription by interacting with the transcriptional machinery bound to the basal promoter in conjunction with adaptor proteins, possibly by acetylation and destabilization of nucleosomes. The protein encoded by this gene is a transcriptional activator adaptor and a component of the histone acetyl transferase (HAT) coactivator complex which plays a crucial role in chromatin modulation and cell cycle progression. Along with the other components of the complex, this protein links transcriptional activators bound to specific promoters, to histone acetylation and the transcriptional machinery. The protein is also involved in the stabilization and activation of the p53 tumor suppressor protein that plays a role in the cellular response to DNA damage. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

GeneCards Summary for TADA3 Gene

TADA3 (Transcriptional Adaptor 3) is a Protein Coding gene. Diseases associated with TADA3 include epicondylitis and staphyloenterotoxemia. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Promoter Opening. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein domain specific binding.

UniProtKB/Swiss-Prot for TADA3 Gene

  • Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Gene Wiki entry for TADA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TADA3 Gene

Genomics for TADA3 Gene

Genomic Location for TADA3 Gene

Start:
9,779,860 bp from pter
End:
9,793,124 bp from pter
Size:
13,265 bases
Orientation:
Minus strand

Genomic View for TADA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TADA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TADA3 Gene

No data available for Regulatory Elements for TADA3 Gene

Proteins for TADA3 Gene

  • Protein details for TADA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75528-TADA3_HUMAN
    Recommended name:
    Transcriptional adapter 3
    Protein Accession:
    O75528
    Secondary Accessions:
    • Q6FI83
    • Q9UFS2

    Protein attributes for TADA3 Gene

    Size:
    432 amino acids
    Molecular mass:
    48902 Da
    Quaternary structure:
    • The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3. Interacts directly with TADA2L and PCAF and also with the high-risk HPV oncoprotein E6. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. Component of the TFTC-HAT complex. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.

    Alternative splice isoforms for TADA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TADA3 Gene

Proteomics data for TADA3 Gene at MOPED

Post-translational modifications for TADA3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TADA3 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TADA3 Gene

Domains for TADA3 Gene

Protein Domains for TADA3 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TADA3_HUMAN
Family:
  • Belongs to the NGG1 family.:
    • O75528
genes like me logo Genes that share domains with TADA3: view

No data available for Gene Families for TADA3 Gene

Function for TADA3 Gene

Molecular function for TADA3 Gene

UniProtKB/Swiss-Prot Function: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Gene Ontology (GO) - Molecular Function for TADA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 9674425
GO:0003713 transcription coactivator activity IDA 11564863
GO:0004402 contributes_to histone acetyltransferase activity IDA 11564863
GO:0005515 protein binding IPI 15383276
GO:0016922 ligand-dependent nuclear receptor binding IPI 20413580
genes like me logo Genes that share ontologies with TADA3: view

Phenotypes for TADA3 Gene

genes like me logo Genes that share phenotypes with TADA3: view

Animal Models for TADA3 Gene

MGI Knock Outs for TADA3:

miRNA for TADA3 Gene

miRTarBase miRNAs that target TADA3

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TADA3 Gene

Localization for TADA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TADA3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TADA3 Gene COMPARTMENTS Subcellular localization image for TADA3 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for TADA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus TAS 9674425
GO:0005654 nucleoplasm IDA --
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IDA 18838386
GO:0030914 STAGA complex IDA 11564863
genes like me logo Genes that share ontologies with TADA3: view

Pathways for TADA3 Gene

genes like me logo Genes that share pathways with TADA3: view

Pathways by source for TADA3 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for TADA3 Gene

Gene Ontology (GO) - Biological Process for TADA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001932 regulation of protein phosphorylation IEA --
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9674425
GO:0007067 mitotic nuclear division IEA --
genes like me logo Genes that share ontologies with TADA3: view

Transcripts for TADA3 Gene

Unigene Clusters for TADA3 Gene

Transcriptional adaptor 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TADA3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
SP1: -
SP2: - - -
SP3: - -
SP4:
SP5: - - - - -
SP6:
SP7: -
SP8: - - -

Relevant External Links for TADA3 Gene

GeneLoc Exon Structure for
TADA3
ECgene alternative splicing isoforms for
TADA3

Expression for TADA3 Gene

mRNA expression in normal human tissues for TADA3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TADA3 Gene

SOURCE GeneReport for Unigene cluster for TADA3 Gene Hs.386390

mRNA Expression by UniProt/SwissProt for TADA3 Gene

O75528-TADA3_HUMAN
Tissue specificity: Ubiquitously expressed
genes like me logo Genes that share expressions with TADA3: view

Orthologs for TADA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TADA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TADA3 36
  • 99.69 (n)
  • 99.77 (a)
TADA3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TADA3 36
  • 92.28 (n)
  • 100 (a)
TADA3 37
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TADA3 36
  • 92.59 (n)
  • 100 (a)
TADA3 37
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tada3 36
  • 90.35 (n)
  • 99.31 (a)
Tada3 16
Tada3 37
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TADA3 37
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TADA3 37
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tada3 36
  • 90.05 (n)
  • 98.61 (a)
chicken
(Gallus gallus)
Aves TADA3 36
  • 83.72 (n)
  • 92.82 (a)
TADA3 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TADA3 37
  • 91 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC64374 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4150 36
tada3 36
  • 77.78 (n)
  • 87.73 (a)
zebrafish
(Danio rerio)
Actinopterygii tada3l 36
  • 72.54 (n)
  • 79.58 (a)
tada3l 37
  • 79 (a)
OneToOne
wufa03f04 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010459 36
  • 49.61 (n)
  • 40.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta dik 36
  • 47.99 (n)
  • 35.66 (a)
dik 37
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5222 37
  • 44 (a)
OneToOne
Species with no ortholog for TADA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TADA3 Gene

ENSEMBL:
Gene Tree for TADA3 (if available)
TreeFam:
Gene Tree for TADA3 (if available)

Paralogs for TADA3 Gene

No data available for Paralogs for TADA3 Gene

Variants for TADA3 Gene

Sequence variations from dbSNP and Humsavar for TADA3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs293787 -- 9,788,307(+) gtggc(A/G)caatc intron-variant
rs293788 -- 9,788,361(+) ctgcc(G/T)tagcc intron-variant
rs293789 -- 9,788,534(+) gccac(C/T)gcacc intron-variant
rs293790 -- 9,789,428(+) GATGC(A/G)TGGCT intron-variant
rs293791 -- 9,789,996(+) GGGGA(C/G)AAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TADA3 Gene

Variant ID Type Subtype PubMed ID
nsv834615 CNV Loss 17160897

Relevant External Links for TADA3 Gene

HapMap Linkage Disequilibrium report
TADA3

Disorders for TADA3 Gene

(2) University of Copenhagen DISEASES for TADA3 Gene

Relevant External Links for TADA3

Genetic Association Database (GAD)
TADA3
Human Genome Epidemiology (HuGE) Navigator
TADA3
genes like me logo Genes that share disorders with TADA3: view

No data available for UniProtKB/Swiss-Prot for TADA3 Gene

Publications for TADA3 Gene

  1. Histone-like TAFs within the PCAF histone acetylase complex. (PMID: 9674425) Ogryzko V.V. … Nakatani Y. (Cell 1998) 2 3 4
  2. hADA3 is required for p53 activity. (PMID: 11707411) Wang T. … Brachmann R.K. (EMBO J. 2001) 2 3 4
  3. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage- binding factors in vivo. (PMID: 11564863) Martinez E. … Roeder R.G. (Mol. Cell. Biol. 2001) 3 4
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  5. Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction. (PMID: 10373431) Brand M. … Tora L. (J. Biol. Chem. 1999) 3 23

Products for TADA3 Gene

Sources for TADA3 Gene

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