Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TADA3 Gene

protein-coding   GIFtS: 56
GCID: GC03M009822

Transcriptional Adaptor 3

(Previous names: transcriptional adaptor 3 (NGG1 homolog, yeast)-like)
(Previous symbol: TADA3L)
  See TADA3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Transcriptional Adaptor 31 2     hADA32 3
TADA3L1 2 3 5     Transcriptional Adaptor 3 (NGG1 Homolog, Yeast)-Like1
ADA32 3 5     NGG12
STAF542 3     Transcriptional Adapter 32
ADA3 Homolog2 3     Transcriptional Adapter 3-Like3
ADA3-Like Protein2 3     

External Ids:    HGNC: 194221   Entrez Gene: 104742   Ensembl: ENSG000001711487   OMIM: 6029455   UniProtKB: O755283   

Export aliases for TADA3 gene to outside databases

Previous GC identifer: GC03M009797


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TADA3 Gene:
DNA-binding transcriptional activator proteins increase the rate of transcription by interacting with the
transcriptional machinery bound to the basal promoter in conjunction with adaptor proteins, possibly by
acetylation and destabilization of nucleosomes. The protein encoded by this gene is a transcriptional activator
adaptor and a component of the histone acetyl transferase (HAT) coactivator complex which plays a crucial role in
chromatin modulation and cell cycle progression. Along with the other components of the complex, this protein
links transcriptional activators bound to specific promoters, to histone acetylation and the transcriptional
machinery. The protein is also involved in the stabilization and activation of the p53 tumor suppressor protein
that plays a role in the cellular response to DNA damage. Alternate splicing results in multiple transcript
variants of this gene. (provided by RefSeq, May 2013)

GeneCards Summary for TADA3 Gene:
TADA3 (transcriptional adaptor 3) is a protein-coding gene. Diseases associated with TADA3 include epicondylitis, and staphyloenterotoxemia. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and protein domain specific binding.

UniProtKB/Swiss-Prot: TADA3_HUMAN, O75528
Function: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating
histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA
complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC
complex, a complex with histone acetyltransferase activity on histones H3 and H4

Gene Wiki entry for TADA3 (TADA3L) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TADA3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTADA3 promoter sequence
   Search Chromatin IP Primers for TADA3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TADA3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25.3   Ensembl cytogenetic band:  3p25.3   HGNC cytogenetic band: 3p25.3

TADA3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TADA3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M009822:  view genomic region     (about GC identifiers)

Start:
9,821,544 bp from pter      End:
9,834,695 bp from pter
Size:
13,152 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TADA3_HUMAN, O75528 (See protein sequence)
Recommended Name: Transcriptional adapter 3  
Size: 432 amino acids; 48902 Da
Subunit: The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6,
TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and
SPT3. Interacts directly with TADA2L and PCAF and also with the high-risk HPV oncoprotein E6. Component of the
STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L,
TAD1L, TAF10, TAF12, TRRAP and TAF9. Component of the TFTC-HAT complex. Component of the ADA2A-containing complex
(ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1
Secondary accessions: Q6FI83 Q9UFS2
Alternative splicing: 2 isoforms:  O75528-1   O75528-2   

Explore the universe of human proteins at neXtProt for TADA3: NX_O75528

Explore proteomics data for TADA3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TADA3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001265199.1  NP_006345.1  NP_597814.1  

    ENSEMBL proteins: 
     ENSP00000307684   ENSP00000393471   ENSP00000343649   ENSP00000395073  
    Reactome Protein details: O75528

    TADA3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for TADA3
    OriGene Protein Over-expression Lysate for TADA3
    OriGene MassSpec for TADA3
    OriGene Custom Protein Services for TADA3
    GenScript Custom Purified and Recombinant Proteins Services for TADA3
    Novus Biologicals TADA3 Proteins
    Novus Biologicals TADA3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for TADA3
    Cloud-Clone Corp. Proteins for TADA3

     
    Search eBioscience for Proteins for TADA3 

     
    antibodies-online proteins for TADA3 (8 products) 

     
    antibodies-online peptides for TADA3

    TADA3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TADA3
    OriGene Custom Antibody Services for TADA3
    Novus Biologicals TADA3 Antibodies
    Search for Antibodies for TADA3 at Abcam
    Cloud-Clone Corp. Antibodies for TADA3
    ThermoFisher Antibodies for TADA3
    antibodies-online antibodies for TADA3 (38 products) 

    TADA3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TADA3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TADA3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TADA3
    Cloud-Clone Corp. CLIAs for TADA3
    Search eBioscience for ELISAs for TADA3 
    antibodies-online kits for TADA3 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR019340 Histone_AcTrfase_su3

    Graphical View of Domain Structure for InterPro Entry O75528

    ProtoNet protein and cluster: O75528

    UniProtKB/Swiss-Prot: TADA3_HUMAN, O75528
    Similarity: Belongs to the NGG1 family


    Find genes that share domains with TADA3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TADA3_HUMAN, O75528
    Function: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating
    histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA
    complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC
    complex, a complex with histone acetyltransferase activity on histones H3 and H4

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity TAS9674425
    GO:0003713transcription coactivator activity IDA11564863
    GO:0004402contributes to histone acetyltransferase activity IDA11564863
    GO:0005515protein binding IPI15383276
    GO:0016922ligand-dependent nuclear receptor binding IPI--
         
    Find genes that share ontologies with TADA3           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Tada3):
     cellular  embryogenesis  mortality/aging  normal 

    Find genes that share phenotypes with TADA3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tada3tm1.2Viba for TADA3

       genOway: Develop your customized and physiologically relevant rodent model for TADA3

    miRNA
    Products:
        
    miRTarBase miRNAs that target TADA3:
    hsa-mir-186-5p (MIRT045064), hsa-mir-26b-5p (MIRT028985)

    Block miRNA regulation of human, mouse, rat TADA3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TADA3 (see all 9):
    hsa-miR-140-3p hsa-miR-548d-3p hsa-miR-520d-5p hsa-miR-507 hsa-miR-548aa hsa-miR-4325 hsa-miR-4274 hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidTADA3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TADA3
    Predesigned siRNA for gene silencing in human, mouse, rat TADA3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TADA3

    Clone
    Products:
         
    OriGene clones in human, mouse for TADA3 (see all 13)
    OriGene ORF clones in mouse, rat for TADA3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TADA3 (NM_133480)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TADA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TADA3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TADA3
    Browse ESI BIO Cell Lines and PureStem Progenitors for TADA3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TADA3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TADA3_HUMAN, O75528: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005634nucleus IDA--
    GO:0005671Ada2/Gcn5/Ada3 transcription activator complex IDA18838386
    GO:0005730NOT nucleolus IDA--
    GO:0030914STAGA complex IDA11564863

    Find genes that share ontologies with TADA3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for TADA3 About    
    See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34
    2Packaging Of Telomere Ends
    Histone modification0.31
    3Transcription Ligand Dependent Transcription of Retinoid Target genes
    Transcription Ligand Dependent Transcription of Retinoid Target genes


    Find genes that share SuperPaths with TADA3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for TADA3
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes

    1 Reactome Pathway for TADA3
        HATs acetylate histones


        Pathway & Disease-focused RT2 Profiler PCR Array including TADA3: 
              p53 Signaling Pathway in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TADA3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TADA3 (O755281, 2, 3 ENSP000003076844) via UniProtKB, MINT, STRING, and/or I2D (see all 220)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ING5Q8WYH82, 3, ENSP000003221424MINT-3979398 I2D: score=4 STRING: ENSP00000322142
    XRCC6P129562, 3, ENSP000003522574MINT-3979364 I2D: score=3 STRING: ENSP00000352257
    HSPA8P111422, 3MINT-63208 I2D: score=5 
    RFX1P226702, 3MINT-63209 I2D: score=5 
    SAP18O004222, 3MINT-63206 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001932regulation of protein phosphorylation IEA--
    GO:0006325chromatin organization TAS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS9674425
    GO:0007067mitosis IEA--

    Find genes that share ontologies with TADA3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TADA3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TADA3 gene (4 alternative transcripts): 
    NM_001278270.1  NM_006354.3  NM_133480.2  NM_133481.1  

    Unigene Cluster for TADA3:

    Transcriptional adaptor 3
    Hs.386390  [show with all ESTs]
    Unigene Representative Sequence: BC009240
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301964(uc003bsx.1 uc010hcn.1) ENST00000492103(uc003bsw.1)
    ENST00000440161 ENST00000343450(uc003bsy.3) ENST00000492635 ENST00000439043

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TADA3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TADA3 (see all 9):
    hsa-miR-140-3p hsa-miR-548d-3p hsa-miR-520d-5p hsa-miR-507 hsa-miR-548aa hsa-miR-4325 hsa-miR-4274 hsa-miR-524-5p
    SwitchGear 3'UTR luciferase reporter plasmidTADA3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TADA3
    Predesigned siRNA for gene silencing in human, mouse, rat TADA3
    Clone
    Products:
         
    OriGene clones in human, mouse for TADA3 (see all 13)
    OriGene ORF clones in mouse, rat for TADA3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TADA3 (NM_133480)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TADA3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TADA3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TADA3
    OriGene qSTAR qPCR primer pairs in human, mouse for TADA3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TADA3
      QuantiTect SYBR Green Assays in human, mouse, rat TADA3
      QuantiFast Probe-based Assays in human, mouse, rat TADA3

    Additional mRNA sequence: 

    AF069733.1 AK000228.1 AK024982.1 AK292264.1 BC001480.2 BC009240.2 BC013433.1 CR533543.1 

    20 DOTS entries:

    DT.416860  DT.100839926  DT.100839921  DT.100839923  DT.92024454  DT.100031477  DT.99993097  DT.100839925 
    DT.120858226  DT.120858314  DT.100839909  DT.100839917  DT.95267308  DT.100656916  DT.100839913  DT.100839920 
    DT.40252140  DT.95267313  DT.40120060  DT.449750 

    Selected AceView cDNA sequences (see all 647):

    BQ068858 AA005165 BM802194 AA465691 BE018320 BE279559 BM793719 BM475017 
    BM664000 AA365983 BM664981 AI333405 BQ029308 BU542762 BM687422 BP872848 
    BF341135 BU627426 BQ962440 BU526470 BQ900257 NM_006354 BF110348 BQ919223 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TADA3 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
    SP1:                                                                                      -                                                   
    SP2:                                                                                      -           -     -                                 
    SP3:                    -     -                                                                                                               
    SP4:                                                                                                                                          
    SP5:        -     -     -     -     -                                                                                                         


    ECgene alternative splicing isoforms for TADA3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TADA3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGCCCGGC
    TADA3 Expression
    About this image

    TADA3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TADA3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.386390

    UniProtKB/Swiss-Prot: TADA3_HUMAN, O75528
    Tissue specificity: Ubiquitously expressed

        Pathway & Disease-focused RT2 Profiler PCR Array including TADA3: 
              p53 Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TADA3
    OriGene qSTAR qPCR primer pairs in human, mouse for TADA3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TADA3
    QuantiTect SYBR Green Assays in human, mouse, rat TADA3
    QuantiFast Probe-based Assays in human, mouse, rat TADA3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TADA3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for TADA3 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tada31 , 5 transcriptional adaptor 31, 5 90.35(n)1
    99.31(a)1
      6 (52.75 cM)5
    1012061  NM_133932.21  NP_598693.11 
     1133660255 
    chicken
    (Gallus gallus)
    Aves TADA31 transcriptional adaptor 3 83.72(n)
    92.82(a)
      416050  XM_414389.4  XP_414389.2 
    lizard
    (Anolis carolinensis)
    Reptilia TADA36
    transcriptional adaptor 3
    91(a)
    1 ↔ 1
    2(191263694-191271315)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC643742 hypothetical protein MGC64374 79.42(n)    BC056843.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa03f042 wufa03f04 75.7(n)   334785  BC055157.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dik1 diskette 47.99(n)
    35.66(a)
      32787  NM_001272738.1  NP_001259667.1 


    ENSEMBL Gene Tree for TADA3 (if available)
    TreeFam Gene Tree for TADA3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TADA3 (see all 278)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1822052021,2
    --9821160(+) TGTGGA/GGGGCA 1 -- ds50010--------
    rs1397149211,2
    --9821163(+) GGAGGA/GCAGTG 1 -- ds50010--------
    rs1868526831,2
    --9821391(+) GCTAAC/TCGTGA 1 -- ds50010--------
    rs1497714471,2
    --9821392(+) CTAACA/CGTGAA 1 -- ds50010--------
    rs1918413481,2
    --9821482(+) TGTTAC/TGTGCA 1 -- ds50010--------
    rs767632401,2
    C,F--9821555(+) GTGGCC/TATGGG 1 -- ds50011Minor allele frequency- T:0.06EA 120
    rs1828165101,2
    --9821580(+) GCATAC/TCCCCC 1 -- ds50010--------
    rs1888015341,2
    --9821666(+) AAACCA/TCAGCA 1 -- ut310--------
    rs1485819211,2
    C--9821764(+) GGATGA/GTAAAG 1 -- ut310--------
    rs1444766151,2
    --9821817(+) ATCTCA/GGGGAC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TADA3 (9821544 - 9834695 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TADA3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv834615CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TADA3
    DNA2.0 Custom Variant and Variant Library Synthesis for TADA3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 602945    OMIM disorders: --

    2 diseases for TADA3:    
    About MalaCards
    epicondylitis    staphyloenterotoxemia

    2 diseases from the University of Copenhagen DISEASES database for TADA3:
    Staphyloenterotoxemia     Epicondylitis

    Find genes that share disorders with TADA3           About GenesLikeMe

    Genetic Association Database (GAD): TADA3
    Human Genome Epidemiology (HuGE) Navigator: TADA3 (3 documents)

    Export disorders for TADA3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TADA3 gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with TADA3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. hADA3 is required for p53 activity. (PubMed id 11707411)1, 2, 3 Wang T.... Brachmann R.K. (EMBO J. 2001)
    2. Histone-like TAFs within the PCAF histone acetylase complex. (PubMed id 9674425)1, 2, 3 Ogryzko V.V.... Nakatani Y. (Cell 1998)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Human papillomavirus oncoprotein E6 inactivates the transcriptional coactivator human ADA3. (PubMed id 12138191)1, 2 Kumar A.... Band V. (Mol. Cell. Biol. 2002)
    7. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage- binding factors in vivo. (PubMed id 11564863)1, 2 Martinez E.... Roeder R.G. (Mol. Cell. Biol. 2001)
    8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    9. The TAFs in the HAT. (PubMed id 9674419)1, 2 Struhl K. and Moqtaderi Z. (Cell 1998)
    10. Human ADA3 binds to estrogen receptor (ER) and functions as a coactivator for ER-mediated transactivation. (PubMed id 15496419)1, 9 Meng G....Band V. (J. Biol. Chem. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10474 HGNC: 19422 AceView: CAMK1andTADA3L Ensembl:ENSG00000171148 euGenes: HUgn10474
    ECgene: TADA3 H-InvDB: TADA3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TADA3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TADA3 gene:
    Search GeneIP for patents involving TADA3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TADA3   OriGene RNAi products in human, mouse, rat for TADA3  
     OriGene qPCR primer pairs and template standards for TADA3   OriGene Protein Over-expression Lysate for TADA3  
     OriGene MassSpec for TADA3   OriGene clones in human, mouse for TADA3  
     OriGene qSTAR qPCR primer pairs in human, mouse for TADA3   OriGene Purified Protein for TADA3  
     OriGene ORF clones in mouse, rat for TADA3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TADA3   OriGene Custom Protein Services for TADA3  

     
     
     Block miRNA regulation of human, mouse, rat TADA3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TADA3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TADA3 Predesigned siRNA for gene silencing in human, mouse, rat TADA3
     QuantiFast Probe-based Assays in human, mouse, rat TADA3 QuantiTect SYBR Green Assays in human, mouse, rat TADA3
     PCR Arrays including human, mouse, rat TADA3 Search Chromatin IP Primers for TADA3
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TADA3  Search GeneGlobe Interaction Network for TADA3
     Search Regulatory tfbs for TADA3
     GenScript Custom Purified and Recombinant Proteins Services for TADA3 GenScript cDNA clones with any tag delivered in your preferred vector for TADA3
     GenScript Custom Assay Services for TADA3 GenScript Custom overexpressing Cell Line Services for TADA3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TADA3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TADA3 antibodies
     TADA3 proteins
     TADA3 lysates
     Search for Antibodies for TADA3 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for TADA3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for TADA3
     Proteins for TADA3
     Antibodies for TADA3
     ELISAs for TADA3
     CLIAs for TADA3



     Browse ESI BIO Cell Lines and PureStem Progenitors for TADA3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TADA3
     SwitchGear 3'UTR luciferase reporter plasmids for TADA3
     SwitchGear Promoter luciferase reporter plasmids for TADA3
     ThermoFisher Antibodies for TADA3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TADA3
     Browse compounds at ApexBio
     Search Addgene for plasmids for TADA3
      Search eBioscience for proteins for TADA3
      Search eBioscience for elisas for TADA3
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for TADA3
     antibodies-online antibodies for TADA3 (38 products)
     antibodies-online kits for TADA3 (4 products)
     antibodies-online peptides for TADA3
     antibodies-online proteins for TADA3 (8 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TADA3 gene at Home site.
    Version: 3.12.264 25 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4