Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TADA3 Gene

Aliases for TADA3 Gene

  • Transcriptional Adaptor 3 2 3
  • ADA3-Like Protein 3 4
  • ADA3 Homolog 3 4
  • TADA3L 3 4
  • STAF54 3 4
  • HADA3 3 4
  • ADA3 3 4
  • Transcriptional Adaptor 3 (NGG1 Homolog, Yeast)-Like 2
  • Transcriptional Adapter 3-Like 4
  • NGG1 3

External Ids for TADA3 Gene

Previous HGNC Symbols for TADA3 Gene

  • TADA3L

Previous GeneCards Identifiers for TADA3 Gene

  • GC03M009797
  • GC03M009822

Summaries for TADA3 Gene

Entrez Gene Summary for TADA3 Gene

  • DNA-binding transcriptional activator proteins increase the rate of transcription by interacting with the transcriptional machinery bound to the basal promoter in conjunction with adaptor proteins, possibly by acetylation and destabilization of nucleosomes. The protein encoded by this gene is a transcriptional activator adaptor and a component of the histone acetyl transferase (HAT) coactivator complex which plays a crucial role in chromatin modulation and cell cycle progression. Along with the other components of the complex, this protein links transcriptional activators bound to specific promoters, to histone acetylation and the transcriptional machinery. The protein is also involved in the stabilization and activation of the p53 tumor suppressor protein that plays a role in the cellular response to DNA damage. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

GeneCards Summary for TADA3 Gene

TADA3 (Transcriptional Adaptor 3) is a Protein Coding gene. Among its related pathways are Chromatin organization and RNA Polymerase II Transcription Initiation And Promoter Clearance. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein domain specific binding.

UniProtKB/Swiss-Prot for TADA3 Gene

  • Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Gene Wiki entry for TADA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TADA3 Gene

Genomics for TADA3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TADA3 Gene

Chromosome:
3
Start:
9,779,860 bp from pter
End:
9,793,011 bp from pter
Size:
13,152 bases
Orientation:
Minus strand

Genomic View for TADA3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TADA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TADA3 Gene

No data available for Regulatory Elements for TADA3 Gene

Proteins for TADA3 Gene

  • Protein details for TADA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75528-TADA3_HUMAN
    Recommended name:
    Transcriptional adapter 3
    Protein Accession:
    O75528
    Secondary Accessions:
    • Q6FI83
    • Q9UFS2

    Protein attributes for TADA3 Gene

    Size:
    432 amino acids
    Molecular mass:
    48902 Da
    Quaternary structure:
    • The PCAF complex is composed of a number of TBP-associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9, TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs), such as TADA2L/ADA2, TADA3L/ADA3 and SPT3. Interacts directly with TADA2L and PCAF and also with the high-risk HPV oncoprotein E6. Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9. Component of the TFTC-HAT complex. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP, KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1.

    Alternative splice isoforms for TADA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TADA3 Gene

Proteomics data for TADA3 Gene at MOPED

Post-translational modifications for TADA3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TADA3 Gene

No data available for DME Specific Peptides for TADA3 Gene

Domains & Families for TADA3 Gene

Gene Families for TADA3 Gene

Protein Domains for TADA3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TADA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75528

UniProtKB/Swiss-Prot:

TADA3_HUMAN :
  • Belongs to the NGG1 family.
Family:
  • Belongs to the NGG1 family.
genes like me logo Genes that share domains with TADA3: view

Function for TADA3 Gene

Molecular function for TADA3 Gene

UniProtKB/Swiss-Prot Function:
Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Gene Ontology (GO) - Molecular Function for TADA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 9674425
GO:0003713 transcription coactivator activity IDA 11564863
GO:0004402 contributes_to histone acetyltransferase activity IDA 11564863
GO:0005515 protein binding IPI 15383276
GO:0016922 ligand-dependent nuclear receptor binding IPI 20413580
genes like me logo Genes that share ontologies with TADA3: view
genes like me logo Genes that share phenotypes with TADA3: view

Animal Models for TADA3 Gene

MGI Knock Outs for TADA3:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TADA3 Gene

Localization for TADA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TADA3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TADA3 Gene COMPARTMENTS Subcellular localization image for TADA3 gene
Compartment Confidence
nucleus 5
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for TADA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005634 nucleus TAS 9674425
GO:0005654 nucleoplasm IDA --
GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IDA 18838386
GO:0030914 STAGA complex IDA 11564863
genes like me logo Genes that share ontologies with TADA3: view

Pathways & Interactions for TADA3 Gene

genes like me logo Genes that share pathways with TADA3: view

Pathways by source for TADA3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • p53 Signaling Pathway in human,mouse,rat

Gene Ontology (GO) - Biological Process for TADA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001932 regulation of protein phosphorylation IEA --
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 9674425
GO:0007067 mitotic nuclear division IEA --
genes like me logo Genes that share ontologies with TADA3: view

No data available for SIGNOR curated interactions for TADA3 Gene

Drugs & Compounds for TADA3 Gene

No Compound Related Data Available

Transcripts for TADA3 Gene

Unigene Clusters for TADA3 Gene

Transcriptional adaptor 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TADA3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b
SP1: -
SP2: - - -
SP3: - -
SP4:
SP5: - - - - -
SP6:
SP7: -
SP8: - - -

Relevant External Links for TADA3 Gene

GeneLoc Exon Structure for
TADA3
ECgene alternative splicing isoforms for
TADA3

Expression for TADA3 Gene

mRNA expression in normal human tissues for TADA3 Gene

Protein differential expression in normal tissues from HIPED for TADA3 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (32.9) and Testis (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TADA3 Gene



SOURCE GeneReport for Unigene cluster for TADA3 Gene Hs.386390

mRNA Expression by UniProt/SwissProt for TADA3 Gene

O75528-TADA3_HUMAN
Tissue specificity: Ubiquitously expressed
genes like me logo Genes that share expression patterns with TADA3: view

Protein tissue co-expression partners for TADA3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TADA3 Gene

Orthologs for TADA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TADA3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TADA3 35
  • 92.28 (n)
  • 100 (a)
TADA3 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TADA3 35
  • 92.59 (n)
  • 100 (a)
TADA3 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tada3 35
  • 90.35 (n)
  • 99.31 (a)
Tada3 16
Tada3 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TADA3 35
  • 99.69 (n)
  • 99.77 (a)
TADA3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tada3 35
  • 90.05 (n)
  • 98.61 (a)
oppossum
(Monodelphis domestica)
Mammalia TADA3 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TADA3 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves TADA3 35
  • 83.72 (n)
  • 92.82 (a)
TADA3 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TADA3 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.4150 35
tada3 35
  • 77.78 (n)
  • 87.73 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC64374 35
zebrafish
(Danio rerio)
Actinopterygii tada3l 35
  • 72.54 (n)
  • 79.58 (a)
wufa03f04 35
tada3l 36
  • 79 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010459 35
  • 49.61 (n)
  • 40.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta dik 35
  • 47.99 (n)
  • 35.66 (a)
dik 36
  • 24 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5222 36
  • 44 (a)
OneToOne
Species with no ortholog for TADA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TADA3 Gene

ENSEMBL:
Gene Tree for TADA3 (if available)
TreeFam:
Gene Tree for TADA3 (if available)

Paralogs for TADA3 Gene

No data available for Paralogs for TADA3 Gene

Variants for TADA3 Gene

Sequence variations from dbSNP and Humsavar for TADA3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs293790 -- 9,789,428(+) GATGC(A/G)TGGCT intron-variant
rs293791 -- 9,789,996(+) GGGGA(A/C/G)AAGGG intron-variant
rs7627624 -- 9,788,820(+) caggc(A/G)tgagG intron-variant
rs11711241 -- 9,790,286(+) ACTAC(G/T)GAGAT intron-variant
rs17050571 -- 9,790,462(+) TCCAA(C/T)GTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TADA3 Gene

Variant ID Type Subtype PubMed ID
nsv834615 CNV Loss 17160897

Variation tolerance for TADA3 Gene

Residual Variation Intolerance Score: 9.32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.41; 8.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TADA3 Gene

HapMap Linkage Disequilibrium report
TADA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TADA3 Gene

Disorders for TADA3 Gene

Relevant External Links for TADA3

Genetic Association Database (GAD)
TADA3
Human Genome Epidemiology (HuGE) Navigator
TADA3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TADA3
genes like me logo Genes that share disorders with TADA3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TADA3 Gene

Publications for TADA3 Gene

  1. The STAGA subunit ADA2b is an important regulator of human GCN5 catalysis. (PMID: 18936164) Gamper A.M. … Roeder R.G. (Mol. Cell. Biol. 2009) 23 67
  2. HPV16 E6-induced and E6AP-dependent inhibition of the transcriptional coactivator hADA3 in human cervical carcinoma cells. (PMID: 19194825) Hu Y. … Xie X. (Cancer Invest. 2009) 23 67
  3. Transcriptional adaptor ADA3 of Drosophila melanogaster is required for histone modification, position effect variegation, and transcription. (PMID: 17967867) Grau B. … FerrA_s A. (Mol. Cell. Biol. 2008) 23 67
  4. Ankyrin repeats-containing cofactors interact with ADA3 and modulate its co-activator function. (PMID: 18377363) Li C.W. … Chen J.D. (Biochem. J. 2008) 23 67
  5. An essential role of human Ada3 in p53 acetylation. (PMID: 17272277) Nag A. … Band V. (J. Biol. Chem. 2007) 23 67

Products for TADA3 Gene

Sources for TADA3 Gene

Back to Top

Content