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Aliases & Descriptions for TADA2L
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases ADA2 1 , 2 ADA2-like 2 ADA2A 2 FLJ12705 2 KL04P 2 OTTHUMP00000164063 2 hADA2 2
Descriptions ADA2-like protein 3 Transcriptional adapter 2-like 3 transcriptional adaptor 2 (ADA2 homolog, yeast)-like 2 transcriptional adaptor 2 (ADA2, yeast, homolog)-like 1 , 2 transcriptional adaptor 2 alpha 2 transcriptional adaptor 2-like 2
Search outside databases for aliases for TADA2L genePrevious GC identifers: GC17P035151 GC17P037719 GC17P035497 GC17P035962
Summaries for TADA2L (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for TADA2L : Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymeraseII-mediated gene transcription by interacting functionally with the general transcriptionmachinery bound at the basal promoter. Adaptor proteins are usually required for this activation,possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at thepromoter. The protein encoded by this gene is a transcriptional activator adaptor and has beenfound to be part of the PCAF histone acetylase complex. Two transcript variants encoding differentisoforms have been identified for this gene. [provided by RefSeq] UniProtKB/Swiss-Prot: TAD2A_HUMAN, O75478 Function : Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region betweenneighboring nucleosomes. Plays a role in chromatin remodeling (By similarity). Required for thefunction of some acidic activation domains, which activate transcription from a distant site
Gene Wiki entry for TADA2L
Genomic Location for TADA2L
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the TADA2L gene Entrez Gene cytogenetic band: 17q12-q21 Ensembl cytogenetic band: 17q12 HGNC cytogenetic band: 17q12-q21 TADA2L Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure
GeneLoc location for GC17P032841:
(about GC identifiers )
Start:
32,841,078 bp from pter
End:
32,911,709 bp from pter
Size:
70,632 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000017.9 NT_078100.1 Proteins for TADA2L
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
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Abnova ,
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Abcam ,
Biochemical Assays by
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Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: TAD2A_HUMAN, O75478 (See
protein sequence )Recommended Name: Transcriptional adapter 2-alpha Size : 443 amino acids; 51496 Da
Subunit : Interacts with GCN5 and NR3C1. Associated with the P/CAF protein in the PCAF complex.Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, TAF5L/PAF65-beta,TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP
Subcellular location : Nucleus
PDB structures from and Proteopedia : 1X41 (3D)
 
Secondary accessions : A8MVD0 B3KMU9 Q9UCW2 Q9UP49
REFSEQ proteins (2 alternative transcripts):
NP_001479.3 NP_597683.2 ENSEMBL proteins: ENSP00000377918 ENSP00000377915 ENSP00000225396 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: TADA2L 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for TADA2L: Assays for TADA2L:
Protein
Domains/ Families for TADA2L(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry O75478 ProtoNet protein and cluster: O75478
2 Blocks protein families : IPB000433 Zn-finger IPB007526 SWIRM UniProtKB/Swiss-Prot: TAD2A_HUMAN, O75478 Similarity : Contains 1 SANT domainSimilarity : Contains 1 SWIRM domain
Gene Function for TADA2L
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Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001488 Applied Biosystems Silencer ® siRNAs for TADA2L Sigma-Aldrich siRNA for TADA2L Sigma-Aldrich shRNA for TADA2L Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001488                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001488                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001488  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001488 UniProtKB/Swiss-Prot: TAD2A_HUMAN, O75478 Function : Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region betweenneighboring nucleosomes. Plays a role in chromatin remodeling (By similarity). Required for thefunction of some acidic activation domains, which activate transcription from a distant site
Genatlas biochemistry entry for TADA2L :transcriptional adaptor yeast ADA2 homolog,interacting with GCN5L2,ubiquitously expressed,enhancingthe initial rate of RNA polymearse II mediated transcription 3 Gene Ontology (GO) molecular function terms (links to tree view) :
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Pathways & Interactions for TADA2L
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
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Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for TADA2L 5/15 Interacting proteins for TADA2L (ENSP00000225396 3 ) via UniProtKB, MINT, and/or STRING (see all 15
)About this table 2 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006355 regulation of transcription, DNA-dependent
IEA -- GO:0006366 transcription from RNA polymerase II promoter
TAS 8552087
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Drugs & Compounds for TADA2L (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
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Transcripts for TADA2L(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001488 Sigma-Aldrich siRNA for TADA2L Sigma-Aldrich shRNA for TADA2L Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001488 NM_133439
REFSEQ mRNAs for TADA2L gene (2 alternative transcripts): NM_001488.3 NM_133439.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001488 NM_133439
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001488                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001488                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001488  
Additional cDNA sequence: AF064094.1 AF069732.1 AK022767.1 AK096371.1 AK225918.1 BC001172.1 BC011753.2 CR615572.1
15 DOTS entries : DT.40311061 DT.100652497 DT.100023091 DT.100023092 DT.100724658 DT.429448 DT.439866 DT.91811353 DT.95273699 DT.100774204 DT.120931017 DT.91759608 DT.95105280 DT.100654330 DT.120930924
24/112 AceView cDNA sequences (see all 112
):AA809900 AI000805 BQ068240 AI968140 BX370711 CR615572 CF529493 AA856985 AI220840 AL526501 R74011 AA297862 AW298572 BI333991 BC011753 CB215685 BQ187943 AL558913 AI382985 AI379124 BI910656 BF338136 AU126440 AK022767
highest scoring ESTs for TADA2L :AF064094 AA280181 AF069732 AI379124 AK022767 AL699917 AU150932 BC011753 BE294059 BF793504
Unigene Cluster for TADA2L: Transcriptional adaptor 2 (ADA2 homolog, yeast)-like Hs.500066 [show with all ESTs ] Unigene Representative Sequence: AK225918 GeneLoc Exon Structure 5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TADA2L (see all 9
) ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ SP1 :                 -   -             -       -                 SP2 :                               -       -                 SP3 :                 -   -             -                       SP4 :   -   -               -                                   SP5 :   -   -                                                
About this scheme ECgene alternative splicing isoforms for TADA2L 3 Ensembl transcripts including schematic representations : ENST00000394395
ENST00000394392
ENST00000225396
Expression for TADA2L
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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TADA2L expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for TADA2L 1 / 2 / 3
6 probe-sets matching TADA2L gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TCTCTGTTATSOURCE GeneReport for Unigene cluster: Hs.500066 Expression variation in blood from EXPOLDB for TADA2L
UniProtKB/Swiss-Prot: TAD2A_HUMAN, O75478 Tissue specificity : Expressed in all tissues, but most abundantly in testis
Orthologs for TADA2L
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
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Gene Trees according to Ensembl )
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Orthologs for TADA2L gene from 5/18 species (see all 18
)
About this table Species with no ortholog for TADA2L ENSEMBL Gene Tree for TADA2L Paralogs for TADA2L (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for TADA2L gene TADA2B 2
SNPs/Variants for TADA2L (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for TADA2L (up to first 250kb)
Disorders & Mutations for TADA2L
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
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Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
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OMIM: 602276
Medical News for TADA2L (Possibly Related Articles in
Doctor's Guide )
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--
Publications for TADA2L (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/28 PubMed articles for TADA2L gene (see all 28
): Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5. (PubMed id 8552087) 2, 3, 4 Candau R....Berger S.L. (1996) Role of the Ada adaptor complex in gene activation by the glucocorticoid receptor. (PubMed id 9154805) 1, 3, 4 Henriksson A....Wright A.P.H. (1997) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) Histone-like TAFs within the PCAF histone acetylase complex. (PubMed id 9674425) 3, 4 Ogryzko V.V.... Nakatani Y. (1998) The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily. (PubMed id 9885574) 3, 4 Vassilev A....Nakatani Y. (1998) A novel human Ada2 homologue functions with Gcn5 or Brg1 to coactivate transcription. (PubMed id 12972612) 1, 3 Barlev N.A.... Berger S.L. (2003) Role of important hydrophobic amino acids in the interaction between the glucocorticoid receptor tau 1-core activation domain and target factors. (PubMed id 9649342) 1, 3 Almlof T....Wright A.P. (1998) hADA2a and hADA3 are required for acetylation, transcriptional activity and proliferative effects of beta-catenin. (PubMed id 18059173) 3 Yang M....Brachmann R.K. (2008) DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196) 4 Zody M.C.... Nusbaum C. (2006)
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Genome Databases showing TADA2L
(According to
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euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing TADA2L
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