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TADA2L Gene

protein-coding   GIFtS: 60

GC17P032841
transcriptional adaptor 2 (ADA2 homolog, yeast)-like
(Previous names: transcriptional adaptor 2 (ADA2, yeast, homolog)-like )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
ADA2 1, 2
ADA2-like 2
ADA2A 2
FLJ12705 2
KL04P 2
OTTHUMP00000164063 2
hADA2 2
Descriptions
ADA2-like protein 3
Transcriptional adapter 2-like 3
transcriptional adaptor 2 (ADA2 homolog, yeast)-like 2
transcriptional adaptor 2 (ADA2, yeast, homolog)-like 1, 2
transcriptional adaptor 2 alpha 2
transcriptional adaptor 2-like 2
External Ids
HGNC: 115311
Entrez Gene: 68712
UniProtKB: O754783
Ensembl: ENSG000001082647
Search outside databases for aliases for TADA2L gene

Previous GC identifers: GC17P035151 GC17P037719 GC17P035497 GC17P035962

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for TADA2L:
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase
II-mediated gene transcription by interacting functionally with the general transcription
machinery bound at the basal promoter. Adaptor proteins are usually required for this activation,
possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the
promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been
found to be part of the PCAF histone acetylase complex. Two transcript variants encoding different
isoforms have been identified for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: TAD2A_HUMAN, O75478
Function: Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between
neighboring nucleosomes. Plays a role in chromatin remodeling (By similarity). Required for the
function of some acidic activation domains, which activate transcription from a distant site

Gene Wiki entry for TADA2L

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the TADA2L gene  

Entrez Gene cytogenetic band: 17q12-q21   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12-q21

TADA2L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P032841:     (about GC identifiers)

Start:
32,841,078 bp from pter
End:
32,911,709 bp from pter
Size:
70,632 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000017.9  NT_078100.1  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: TAD2A_HUMAN, O75478 (See protein sequence)
Recommended Name: Transcriptional adapter 2-alpha  
Size: 443 amino acids; 51496 Da
Subunit: Interacts with GCN5 and NR3C1. Associated with the P/CAF protein in the PCAF complex.
Component of the PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, TAF5L/PAF65-beta,
TAF6L/PAF65-alpha, TAF10/TAFII30, TAF12/TAFII20, TAF9/TAFII31 and TRRAP
Subcellular location: Nucleus
PDB structures from and Proteopedia :
1X41 (3D)    
Secondary accessions: A8MVD0 B3KMU9 Q9UCW2 Q9UP49

REFSEQ proteins (2 alternative transcripts): 
NP_001479.3  NP_597683.2  


ENSEMBL proteins: 
ENSP00000377918 ENSP00000377915 ENSP00000225396 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (ADA2a)
Human Recombinant Proteins from Abnova (TADA2L)
              OriGene Purified Recombinant Human Protein: TADA2L 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus TAS8552087
GO:0005694 chromosome IEA--
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Antibodies for TADA2L: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for TADA2L
Browse R&D Systems for Antibodies
Antibodies from Abcam (ADA2a), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (TADA2L)
Novus Biologicals Antibody for TADA2L

Assays for TADA2L: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

5/7 InterPro domains/families (see all 7 ):
 IPR017884 SANT_eukarya
 IPR001005 SANT_DNA-bd
 IPR016827 Transcriptional_adaptor_2
 IPR014778 Myb_DNA-bd
 IPR007526 SWIRM


   GeneDecks  TADA2L for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry O75478

ProtoNet protein and cluster: O75478

2 Blocks protein families:
IPB000433 Zn-finger
IPB007526 SWIRM


UniProtKB/Swiss-Prot: TAD2A_HUMAN, O75478
Similarity: Contains 1 SANT domain
Similarity: Contains 1 SWIRM domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (TADA2L)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (TADA2L)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001488

              Applied Biosystems Silencer® siRNAs for TADA2L

              Sigma-Aldrich siRNA for TADA2L  
                     Sigma-Aldrich shRNA for TADA2L  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for TADA2L
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001488
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001488
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001488 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001488

UniProtKB/Swiss-Prot: TAD2A_HUMAN, O75478
Function: Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between
neighboring nucleosomes. Plays a role in chromatin remodeling (By similarity). Required for the
function of some acidic activation domains, which activate transcription from a distant site

Genatlas biochemistry entry for TADA2L:
transcriptional adaptor yeast ADA2 homolog,interacting with GCN5L2,ubiquitously expressed,enhancing
the initial rate of RNA polymearse II mediated transcription

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003700 transcription factor activity TAS8552087
GO:0003712 transcription cofactor activity TAS8552087
GO:0008270 zinc ion binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Invitrogen iPath™ Online BioAtlas - Pathway for TADA2L (Maps provided by GeneGo):
 Ligand-Dependent Transcription of Retinoid-Target genes

   GeneDecks  TADA2L for the pathways selected above  
About GeneDecksing

1 Millipore Pathway for TADA2L
 Transcription Ligand-Dependent Transcription of Retinoid-Target genes

   GeneDecks  TADA2L for the pathways selected above  
About GeneDecksing

 Gene Network CentralTM Interacting Genes and Proteins Network for  TADA2L 


5/15 Interacting proteins for TADA2L (ENSP000002253963) via UniProtKB, MINT, and/or STRING (see all 15 )
InteractantInteraction Details
GeneCardExternal ID(s)
KAT2AENSP000002259163STRING (score=.998)
KAT2BENSP000002637543STRING (score=.972)
TRRAPENSP000003529253STRING (score=.879)
TMPRSS11DENSP000002839163STRING (score=.878)
ADAENSP000003619653STRING (score=.827)
About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006355 regulation of transcription, DNA-dependent IEA--
GO:0006366 transcription from RNA polymerase II promoter TAS8552087
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for TADA2L

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (TADA2L)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (TADA2L)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001488

              Sigma-Aldrich siRNA for TADA2L  
                     Sigma-Aldrich shRNA for TADA2L  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001488  NM_133439  

REFSEQ mRNAs for TADA2L gene (2 alternative transcripts): 

NM_001488.3   NM_133439.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001488  NM_133439  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001488
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001488
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001488 

Additional cDNA sequence: 

AF064094.1 AF069732.1 AK022767.1 AK096371.1 AK225918.1 BC001172.1 BC011753.2 CR615572.1 

15 DOTS entries:

DT.40311061  DT.100652497  DT.100023091  DT.100023092  DT.100724658  DT.429448  DT.439866  DT.91811353 
DT.95273699  DT.100774204  DT.120931017  DT.91759608  DT.95105280  DT.100654330  DT.120930924 

24/112 AceView cDNA sequences (see all 112 ):

AA809900 AI000805 BQ068240 AI968140 BX370711 CR615572 CF529493 AA856985 
AI220840 AL526501 R74011 AA297862 AW298572 BI333991 BC011753 CB215685 
BQ187943 AL558913 AI382985 AI379124 BI910656 BF338136 AU126440 AK022767 

highest scoring ESTs for TADA2L:

AF064094 AA280181 AF069732 AI379124 AK022767 AL699917 AU150932 BC011753 BE294059 BF793504 

Unigene Cluster for TADA2L:

Transcriptional adaptor 2 (ADA2 homolog, yeast)-like
Hs.500066  [show with all ESTs]
Unigene Representative Sequence: AK225918


GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TADA2L (see all 9 )

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^
SP1:                                                  -     -                                   -                 -                                             
SP2:                                                                                            -                 -                                             
SP3:                                                  -     -                                   -                                                               
SP4:        -     -                                         -                                                                                                   
SP5:        -     -                                                                                                                                             

ExUns: 19
SP1:      
SP2:      
SP3:      
SP4:      
SP5:      

About this scheme

ECgene alternative splicing isoforms for TADA2L

3 Ensembl transcripts including schematic representations:
ENST00000394395  ENST00000394392  ENST00000225396  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

TADA2L expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for TADA2L

1 / 2 / 3

6 probe-sets matching TADA2L gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

37789_at2, 3 U95-A 1 1.00 1.00 0.15 0.26 AF064094 1.00 1.00 1.00 1

77102_at2, 3 U95-E 1 1.00 1.00 1.00 1.00 AI379124 0.80 1.00 0.91 1

210537_s_at2, 3 U133-A 1 1.00 1.00 -- -- BC001172 0.60 1.00 0.82 1

209938_at2, 3 U133-A 1 1.00 1.00 -- -- AF064094 1.00 1.00 1.00 1

210537_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

209938_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TCTCTGTTAT

SOURCE GeneReport for Unigene cluster: Hs.500066

Expression variation in blood from EXPOLDB for TADA2L

UniProtKB/Swiss-Prot: TAD2A_HUMAN, O75478
Tissue specificity: Expressed in all tissues, but most abundantly in testis

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for TADA2L gene from 5/18 species (see all 18 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
TADA2L1   -- transcriptional adaptor 2 (ADA2 homolog, yeast)-like 95.4(n)
99.1(a)
480596  XM_848485.1  XP_853578.1 
chimpanzee
(Pan troglodytes)
TADA2L1   -- transcriptional adaptor 2 (ADA2 homolog, yeast)-like 99.85(n)
99.77(a)
454605  XM_001173478.1  XP_001173478.1 
cow
(Bos taurus)
TADA2L1   -- transcriptional adaptor 2 (ADA2 homolog, yeast)-like 94.34(n)
98.87(a)
505401  NM_001034244.1  NP_001029416.1 
rat
(Rattus norvegicus)
Tada2l1   -- transcriptional adaptor 2 (ADA2 homolog, yeast)-like 90.57(n)
97.74(a)
360581  NM_001012141.1  NP_001012141.1 
mouse
(Mus musculus)
Tada2l1, 5 115
transcriptional adaptor 2 (ADA2 homolog, yeast)-like1, 5 90.57(n)1
97.29(a)1
2170311  NM_172562.21  NP_766150.11 
 AK0834675  AK1358025  (see all 17)
About this table        Species with no ortholog for TADA2L

ENSEMBL Gene Tree for TADA2L
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for TADA2L gene
TADA2B2  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/394 NCBI SNPs in TADA2L are shown (see all 394 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 96)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 17 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs118679831,2
A,C,F,H32900295(+) TTTCTG/ATGAGA 2 -- int1 ng3115Minor allele frequency- A:0.18EU EA WA NA 1340
rs171387661,2
C,F,H32845550(+) GCACTC/AGTTGC 2 -- ut51 ese37Minor allele frequency- A:0.05NA EU EA WA 562
rs72118751,2
C,F,H32845581(+) TGGGTC/TCCTTT 2 P/S mis1 ese312Minor allele frequency- N:0.00EU EA WA NA 1042
rs25229691,2
C,F,H32905335(+) TCCATT/GCCAAT 1 M/I mis18Minor allele frequency- G:0.01EU EA WA 836
rs10548651,2
C,H32874777(+) ACTATA/GTGAAG 2 M/V mis14Minor allele frequency- G:0.00EU EA WA 418
rs28986561,2
A,C,F,H,O32880531(-) TCAAAG/AGGAAC 2 -- int17Minor allele frequency- A:0.18EU EA WA NA 560
rs8532051,2
A,C,F,H,O32898509(+) AAAGGT/CAAAAT 2 -- int17Minor allele frequency- C:0.36EU EA WA NA 560
rs8532191,2
A,C,F,H,O32861508(+) TGATAC/TGAGGA 2 -- int19Minor allele frequency- T:0.26EA EU WA 2130
rs26807201,2
A,C,F,H,O32892575(-) CATAAT/AGAATT 2 -- int111Minor allele frequency- A:0.35EU EA WA NA 980
rs8532311,2
A,C,F,H,O32888496(+) CGAGGA/GCATTA 2 -- int17Minor allele frequency- G:0.35EU EA WA NA 562
About this table

HapMap Linkage Disequilibrium images for TADA2L (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602276

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/28 PubMed articles for TADA2L gene (see all 28 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 6871 HGNC: 11531 AceView: TADA2L Ensembl:ENSG00000108264 euGenes: HUgn6871
ECgene: TADA2L H-InvDB: TADA2L
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
ATLAS Chromosomes in Cancer entry for TADA2L Genetics and Cytogenetics in Oncology and Haematology
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for TADA2L:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 Predesigned and custom siRNAs for TADA2L Antibodies for TADA2L
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
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 shRNA in GFP-retroviral vector
 Search Tocris compounds for TADA2L




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