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Aliases for TADA2B Gene

Aliases for TADA2B Gene

  • Transcriptional Adaptor 2B 2 3 5
  • ADA2-Like Protein Beta 3 4
  • ADA2-Beta 3 4
  • ADA2B 3 4
  • Transcriptional Adaptor 2 (ADA2 Homolog, Yeast)-Beta 3
  • Transcriptional Adapter 2-Beta 3
  • ADA2(Beta) 3

External Ids for TADA2B Gene

Previous GeneCards Identifiers for TADA2B Gene

  • GC04P007096
  • GC04P006972

Summaries for TADA2B Gene

Entrez Gene Summary for TADA2B Gene

  • TADA2B functions as a transcriptional adaptor protein that potentiates transcription through coordination of histone acetyltransferase (HAT) activity and by linking activation factors to basal transcriptional machinery (Barlev et al., 2003 [PubMed 12972612]).[supplied by OMIM, Apr 2010]

GeneCards Summary for TADA2B Gene

TADA2B (Transcriptional Adaptor 2B) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Direct p53 effectors. Gene Ontology (GO) annotations related to this gene include chromatin binding. An important paralog of this gene is TADA2A.

UniProtKB/Swiss-Prot for TADA2B Gene

  • Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2.

Additional gene information for TADA2B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TADA2B Gene

Genomics for TADA2B Gene

GeneHancer (GH) Regulatory Elements for TADA2B Gene

Promoters and enhancers for TADA2B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I007041 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +1.6 1581 3.5 HDGF PKNOX1 ATF1 ZFP64 ARID4B SIN3A GLI4 ZNF48 YY1 GLIS2 CCDC96 TADA2B GRPEL1 LOC100129931
GH04I006914 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 6.2 -125.3 -125260 5.1 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 KIAA0232 TBC1D14 BLOC1S4 GRPEL1 TADA2B MAN2B2 S100P GC04M006908 GC04P006943
GH04I006781 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.2 -259.3 -259269 3.2 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 POLR2B ZNF207 ZNF143 SP3 SP5 KIAA0232 TADA2B TBC1D14 GC04P006772 GC04P006842
GH04I007049 Enhancer 0.6 ENCODE 12 +8.8 8780 1.7 MNT REST ZFHX2 GLIS2 EGR1 SCRT2 ZBTB33 HNF4A EGR2 GRPEL1 TADA2B LOC100129931 GC04P007056 PIR50468
GH04I007045 Enhancer 0.5 ENCODE 13.7 +4.7 4658 1.3 NR2F1 SCRT2 EBF1 IRF4 RUNX3 LOC100129931 TADA2B GC04P007056 PIR50468
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TADA2B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TADA2B gene promoter:

Genomic Locations for TADA2B Gene

Genomic Locations for TADA2B Gene
chr4:7,041,899-7,057,952
(GRCh38/hg38)
Size:
16,054 bases
Orientation:
Plus strand
chr4:7,043,626-7,059,679
(GRCh37/hg19)

Genomic View for TADA2B Gene

Genes around TADA2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TADA2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TADA2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TADA2B Gene

Proteins for TADA2B Gene

  • Protein details for TADA2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TJ2-TAD2B_HUMAN
    Recommended name:
    Transcriptional adapter 2-beta
    Protein Accession:
    Q86TJ2
    Secondary Accessions:
    • A0AUJ8
    • A4QMR7
    • B3KSN0
    • B3KU86
    • Q6MZG9

    Protein attributes for TADA2B Gene

    Size:
    420 amino acids
    Molecular mass:
    48470 Da
    Quaternary structure:
    • Interacts with GCN5L2, SMARCA4, SMARCE1 and PAX5. Component of the TFTC-HAT complex.
    SequenceCaution:
    • Sequence=AAH47794.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI01338.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TADA2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TADA2B Gene

Post-translational modifications for TADA2B Gene

No Post-translational modifications

Other Protein References for TADA2B Gene

No data available for DME Specific Peptides for TADA2B Gene

Domains & Families for TADA2B Gene

Gene Families for TADA2B Gene

Protein Domains for TADA2B Gene

Suggested Antigen Peptide Sequences for TADA2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TADA2B: view

No data available for UniProtKB/Swiss-Prot for TADA2B Gene

Function for TADA2B Gene

Molecular function for TADA2B Gene

UniProtKB/Swiss-Prot Function:
Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2.

Phenotypes From GWAS Catalog for TADA2B Gene

Gene Ontology (GO) - Molecular Function for TADA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IBA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0003713 transcription coactivator activity IBA --
GO:0004402 contributes_to histone acetyltransferase activity IBA --
genes like me logo Genes that share ontologies with TADA2B: view
genes like me logo Genes that share phenotypes with TADA2B: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TADA2B Gene

Localization for TADA2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TADA2B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TADA2B gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TADA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0030914 STAGA complex IEA --
GO:0070461 SAGA-type complex IDA 18838386
genes like me logo Genes that share ontologies with TADA2B: view

Pathways & Interactions for TADA2B Gene

genes like me logo Genes that share pathways with TADA2B: view

Pathways by source for TADA2B Gene

Gene Ontology (GO) - Biological Process for TADA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006338 chromatin remodeling IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA --
GO:0016573 histone acetylation IEA --
genes like me logo Genes that share ontologies with TADA2B: view

No data available for SIGNOR curated interactions for TADA2B Gene

Drugs & Compounds for TADA2B Gene

No Compound Related Data Available

Transcripts for TADA2B Gene

Unigene Clusters for TADA2B Gene

Transcriptional adaptor 2B:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TADA2B Gene

No ASD Table

Relevant External Links for TADA2B Gene

GeneLoc Exon Structure for
TADA2B
ECgene alternative splicing isoforms for
TADA2B

Expression for TADA2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TADA2B Gene

mRNA differential expression in normal tissues according to GTEx for TADA2B Gene

This gene is overexpressed in Muscle - Skeletal (x4.2).

Protein differential expression in normal tissues from HIPED for TADA2B Gene

This gene is overexpressed in Lung (15.7), Cerebrospinal fluid (6.7), and Urinary Bladder (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TADA2B Gene



Protein tissue co-expression partners for TADA2B Gene

NURSA nuclear receptor signaling pathways regulating expression of TADA2B Gene:

TADA2B

SOURCE GeneReport for Unigene cluster for TADA2B Gene:

Hs.518614

Evidence on tissue expression from TISSUES for TADA2B Gene

  • Nervous system(4.3)
  • Intestine(4.2)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with TADA2B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TADA2B Gene

Orthologs for TADA2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TADA2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TADA2B 33 34
  • 99.7 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 94 (a)
OneToMany
TADA2B 33 34
  • 88.65 (n)
mouse
(Mus musculus)
Mammalia Tada2b 33 16 34
  • 88.57 (n)
rat
(Rattus norvegicus)
Mammalia Tada2b 33
  • 88.1 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 88 (a)
OneToMany
-- 34
  • 53 (a)
OneToMany
-- 34
  • 21 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TADA2B 33 34
  • 85.57 (n)
oppossum
(Monodelphis domestica)
Mammalia TADA2B 34
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves TADA2B 33 34
  • 84.6 (n)
lizard
(Anolis carolinensis)
Reptilia TADA2B 34
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tada2b 33
  • 77.38 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18623 33
zebrafish
(Danio rerio)
Actinopterygii tada2b 33 34
  • 76.83 (n)
wufb72h11 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003109 33
  • 54.68 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ada2b 33 34
  • 54.17 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ADA2 34
  • 26 (a)
OneToMany
Species where no ortholog for TADA2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TADA2B Gene

ENSEMBL:
Gene Tree for TADA2B (if available)
TreeFam:
Gene Tree for TADA2B (if available)

Paralogs for TADA2B Gene

Paralogs for TADA2B Gene

(1) SIMAP similar genes for TADA2B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TADA2B: view

Variants for TADA2B Gene

Sequence variations from dbSNP and Humsavar for TADA2B Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000320286 -- 7,051,204(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000346404 -- 7,042,451(+) T/C upstream_transcript_variant
rs1000357659 -- 7,056,998(+) C/T 3_prime_UTR_variant
rs1000385053 -- 7,056,686(+) G/A 3_prime_UTR_variant
rs1000404803 -- 7,056,060(+) T/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for TADA2B Gene

Variant ID Type Subtype PubMed ID
dgv8941n54 CNV gain 21841781
esv26516 CNV loss 19812545
esv2759221 CNV gain 17122850
esv34033 CNV loss 18971310
esv34196 OTHER inversion 12058347
nsv4217 CNV deletion 18451855
nsv428436 CNV gain 18775914
nsv469847 CNV gain 16826518
nsv593548 CNV loss 21841781
nsv593549 CNV gain+loss 21841781
nsv593550 CNV gain 21841781
nsv593556 CNV gain 21841781

Variation tolerance for TADA2B Gene

Residual Variation Intolerance Score: 15.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TADA2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TADA2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TADA2B Gene

Disorders for TADA2B Gene

Additional Disease Information for TADA2B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TADA2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TADA2B Gene

Publications for TADA2B Gene

  1. A novel human Ada2 homologue functions with Gcn5 or Brg1 to coactivate transcription. (PMID: 12972612) Barlev NA … Berger SL (Molecular and cellular biology 2003) 2 3 4 22 58
  2. The STAGA subunit ADA2b is an important regulator of human GCN5 catalysis. (PMID: 18936164) Gamper AM … Roeder RG (Molecular and cellular biology 2009) 2 3 22 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TADA2B Gene

Sources for TADA2B Gene

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