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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TADA2B Gene

protein-coding   GIFtS: 48
GCID: GC04P007043

Transcriptional Adaptor 2B

  Search for TADA2B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transcriptional Adaptor 2B1 2     ADA2(beta)2
ADA2B2 3 5     Transcriptional Adapter 2-Beta2
ADA2-beta2 3     Transcriptional Adaptor 2 (ADA2 Homolog, Yeast)-Beta2
ADA2-Like Protein Beta2 3     

External Ids:    HGNC: 307811   Entrez Gene: 936242   Ensembl: ENSG000001730117   OMIM: 6087905   UniProtKB: Q86TJ23   

Export aliases for TADA2B gene to outside databases

Previous GC identifers: GC04P007096 GC04P006972


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TADA2B Gene:
TADA2B functions as a transcriptional adaptor protein that potentiates transcription through coordination of
histone acetyltransferase (HAT) activity and by linking activation factors to basal transcriptional machinery
(Barlev et al., 2003 (PubMed 12972612)).(supplied by OMIM, Apr 2010)

GeneCards Summary for TADA2B Gene: 
TADA2B (transcriptional adaptor 2B) is a protein-coding gene. GO annotations related to this gene include chromatin binding and DNA binding. An important paralog of this gene is TADA2A.

UniProtKB/Swiss-Prot: TAD2B_HUMAN, Q86TJ2
Function: Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_006051.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TADA2B gene promoter:
         ER-alpha   Elk-1   AML1a   NCX/Ncx   Nkx2-5   E47   GATA-1   Evi-1   CREB   deltaCREB   
         Other transcription factors

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   Search SABiosciences Chromatin IP Primers for TADA2B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TADA2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4p16.1   Ensembl cytogenetic band:  4p16.1   HGNC cytogenetic band: 4p16.1

TADA2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TADA2B gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P007043:  view genomic region     (about GC identifiers)

Start:
7,043,626 bp from pter      End:
7,059,679 bp from pter
Size:
16,054 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TAD2B_HUMAN, Q86TJ2 (See protein sequence)
Recommended Name: Transcriptional adapter 2-beta  
Size: 420 amino acids; 48470 Da
Subunit: Interacts with GCN5L2, SMARCA4, SMARCE1 and PAX5. Component of the TFTC-HAT complex
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAH47794.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAI01338.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A0AUJ8 A4QMR7 B3KSN0 B3KU86 Q6MZG9
Alternative splicing: 3 isoforms:  Q86TJ2-1   Q86TJ2-2   Q86TJ2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TADA2B: NX_Q86TJ2

Explore proteomics data for TADA2B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86TJ2

  • TADA2B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TADA2B Protein Expression
    REFSEQ proteins: NP_689506.2  
    ENSEMBL proteins: 
     ENSP00000422398   ENSP00000308022   ENSP00000423947   ENSP00000423181   ENSP00000425731  

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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030914STAGA complex IEA--
    GO:0070461SAGA-type complex IDA18838386

    TADA2B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR017884 SANT_dom
     IPR001005 SANT/Myb
     IPR016827 Transcriptional_adaptor_2
     IPR009057 Homeodomain-like
     IPR000433 Znf_ZZ

    Graphical View of Domain Structure for InterPro Entry Q86TJ2

    ProtoNet protein and cluster: Q86TJ2

    1 Blocks protein domain: IPB000433 Zn-finger

    UniProtKB/Swiss-Prot: TAD2B_HUMAN, Q86TJ2
    Similarity: Contains 1 SANT domain
    Similarity: Contains 1 ZZ-type zinc finger


    TADA2B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAD2B_HUMAN, Q86TJ2
    Function: Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    TADA2B for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for TADA2B:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TADA2B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Direct p53 effectors
    Direct p53 effectors


    1 BioSystems Pathway for TADA2B
        Direct p53 effectors


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TADA2B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/45 Interacting proteins for TADA2B (Q86TJ23 ENSP000003080224) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TADA3O755283, ENSP000003076844I2D: score=5 STRING: ENSP00000307684
    TAF9BQ9HBM63, ENSP000003399174I2D: score=2 STRING: ENSP00000339917
    TADA2AO754783, ENSP000002253964I2D: score=1 STRING: ENSP00000225396
    TAF5Q155423, ENSP000003588544I2D: score=1 STRING: ENSP00000358854
    TBPP202263, ENSP000002303544I2D: score=1 STRING: ENSP00000230354
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--

    TADA2B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TADA2B (TAD2B)

    Search CenterWatch for drugs/clinical trials and news about TADA2B / TAD2B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TADA2B gene: 
    NM_152293.2  

    Unigene Cluster for TADA2B:

    Transcriptional adaptor 2B
    Hs.518614  [show with all ESTs]
    Unigene Representative Sequence: NM_152293
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000506692 ENST00000310074(uc003gjw.4 uc010idi.3) ENST00000512388
    ENST00000515646(uc021xle.1) ENST00000510704
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    Additional mRNA sequence: 

    AK026299.1 AK093974.1 AK096655.1 AK126966.1 BC013164.1 BC047794.1 BC064337.1 BC078156.1 
    BC101334.1 BC101335.1 BC101336.1 BC101337.2 BX641147.1 BX648428.1 

    5 DOTS entries:

    DT.101982425  DT.97771399  DT.100033568  DT.40234811  DT.95262370 

    24/123 AceView cDNA sequences (see all 123):

    AI299146 F03384 BI829835 AI609071 AW452070 AI299860 AA497090 BM707675 
    BM699992 AW264116 BF221826 CD743174 AA400183 CD370689 CK904021 BM761212 
    AA599233 F02091 BM844330 BU621750 AI140813 BM007893 BM980519 BU860474 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TADA2B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCGCCTGGC
    TADA2B Expression
    About this image


    See TADA2B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TADA2B

    SOURCE GeneReport for Unigene cluster: Hs.518614
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TADA2B gene from 8/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tada2b1 , 5 transcriptional adaptor 2B1, 5 88.57(n)1
    99.29(a)1
      5 (19.14 cM)5
    2311511  NM_001170454.11  NP_001163925.11 
     364736705 
    chicken
    (Gallus gallus)
    Aves TADA2B1 transcriptional adaptor 2B 84.6(n)
    95.48(a)
      428796  XM_426352.2  XP_426352.1 
    lizard
    (Anolis carolinensis)
    Reptilia TADA2B6
    Uncharacterized protein
    93(a)
    1 ↔ 1
    4(79471202-79475828)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.186232 Xenopus laevis transcribed sequences 78.59(n)    BX843502.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb72h112 Danio rerio cDNA clone IMAGE3819303, partial cds 78.63(n)    BC055562.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ada2b1 Ada2b 54.06(n)
    44.08(a)
      40966  NM_001031980.1  NP_001027151.1 
    worm
    (Caenorhabditis elegans)
    Secernentea ada-26
    Protein ADA-2, isoform a
    10(a)
    1 ↔ 1
    II(7252259-7255738)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ADA26
    Transcription coactivator, component of the ADA an...
    24(a)
    1 → many
    IV(1356065-1357369)


    ENSEMBL Gene Tree for TADA2B (if available)
    TreeFam Gene Tree for TADA2B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TADA2B gene
    TADA2A2  
    1 SIMAP similar gene for TADA2B using alignment to 3 protein entries:     TAD2B_HUMAN (see all proteins):
    TADA2A

    TADA2B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/246 SNPs in TADA2B are shown (see all 246)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs109377811,2
    C,H--7050111(+) CCTGGC/TTTACC 1 -- int113Minor allele frequency- T:0.04NA WA CSA EA 377
    rs99857041,2
    C,F,A,H--7050377(+) CACTCA/CCAGTG 1 -- int125Minor allele frequency- C:0.05NS EA NA WA CSA 2143
    rs99860371,2
    C,F,A,H--7050610(+) gtgttG/Atggca 1 -- int112Minor allele frequency- A:0.33NA WA CSA EA 373
    rs1163156201,2
    F--7050612(+) GTTGTG/AGCATG 1 -- int11Minor allele frequency- A:0.03WA 118
    rs1113709701,2
    C,F--7050660(+) TTGTCA/GTCTGT 1 -- int12Minor allele frequency- G:0.04CSA WA 119
    rs1385720441,2
    --7050698(+) TGTGAC/TGGACA 1 -- int10--------
    rs1491871141,2
    --7050742(+) AAGGCC/TGCTAT 1 -- int10--------
    rs1433495481,2
    --7050758(+) TGGTGG/TTGAGG 1 -- int10--------
    rs1482130861,2
    --7050794(+) AATTGC/TTAGGT 1 -- int10--------
    rs340624801,2
    C--7050816(+) TTTTT-/TAAGGG 1 -- int12Minor allele frequency- T:0.00NA CSA 4

    HapMap Linkage Disequilibrium report for TADA2B (7043626 - 7059679 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for TADA2B (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv878532CNV Loss21882294
    esv34033CNV Loss18971310
    esv26516CNV Loss19812545
    nsv4217CNV Loss18451855
    nsv878530CNV Loss21882294
    nsv878531CNV Loss21882294
    nsv878533CNV Loss21882294
    nsv428436CNV Gain18775914
    nsv469847CNV Complex16826518
    dgv1568e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TADA2B for disorders           About MalaCards
    OMIM gene information: 608790    OMIM disorders: --


    TADA2B for disorders           About GeneDecksing

    Genetic Association Database (GAD): TADA2B
    Human Genome Epidemiology (HuGE) Navigator: TADA2B (1 document)

    Export disorders for TADA2B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TADA2B gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with TADA2B)
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    1. A novel human Ada2 homologue functions with Gcn5 or Brg1 to coactivate transcription. (PubMed id 12972612)1, 2, 3, 9 Barlev N.A.... Berger S.L. (2003)
    2. The STAGA subunit ADA2b is an important regulator of human GCN5 catalysis. (PubMed id 18936164)1, 3, 9 Gamper A.M....Roeder R.G. (2009)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    8. Activator-Mediator binding regulates Mediator-cofacto r interactions. (PubMed id 20534441)1 Ebmeier C.C. and Taatjes D.J. (2010)
    9. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
    10. Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. (PubMed id 18838386)1 Wang Y.L....Martinez E. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 93624 HGNC: 30781 AceView: MGC21874 Ensembl:ENSG00000173011 euGenes: HUgn93624
    ECgene: TADA2B H-InvDB: TADA2B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TADA2B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TADA2B gene:
    Search GeneIP for patents involving TADA2B

    GeneCards and IP:
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