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Aliases for TADA2B Gene

Aliases for TADA2B Gene

  • Transcriptional Adaptor 2B 2 3 5
  • ADA2-Like Protein Beta 3 4
  • ADA2-Beta 3 4
  • ADA2B 3 4
  • Transcriptional Adaptor 2 (ADA2 Homolog, Yeast)-Beta 3
  • ADA2(Beta) 3

External Ids for TADA2B Gene

Previous GeneCards Identifiers for TADA2B Gene

  • GC04P007096
  • GC04P006972

Summaries for TADA2B Gene

Entrez Gene Summary for TADA2B Gene

  • TADA2B functions as a transcriptional adaptor protein that potentiates transcription through coordination of histone acetyltransferase (HAT) activity and by linking activation factors to basal transcriptional machinery (Barlev et al., 2003 [PubMed 12972612]).[supplied by OMIM, Apr 2010]

GeneCards Summary for TADA2B Gene

TADA2B (Transcriptional Adaptor 2B) is a Protein Coding gene. Among its related pathways are Chromatin organization and Direct p53 effectors. GO annotations related to this gene include chromatin binding. An important paralog of this gene is TADA2A.

UniProtKB/Swiss-Prot for TADA2B Gene

  • Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TADA2B Gene

Genomics for TADA2B Gene

Regulatory Elements for TADA2B Gene

Enhancers for TADA2B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TADA2B on UCSC Golden Path with GeneCards custom track

Promoters for TADA2B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TADA2B on UCSC Golden Path with GeneCards custom track

Genomic Location for TADA2B Gene

7,041,899 bp from pter
7,057,952 bp from pter
16,054 bases
Plus strand

Genomic View for TADA2B Gene

Genes around TADA2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TADA2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TADA2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TADA2B Gene

Proteins for TADA2B Gene

  • Protein details for TADA2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transcriptional adapter 2-beta
    Protein Accession:
    Secondary Accessions:
    • A0AUJ8
    • A4QMR7
    • B3KSN0
    • B3KU86
    • Q6MZG9

    Protein attributes for TADA2B Gene

    420 amino acids
    Molecular mass:
    48470 Da
    Quaternary structure:
    • Interacts with GCN5L2, SMARCA4, SMARCE1 and PAX5. Component of the TFTC-HAT complex.
    • Sequence=AAH47794.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI01338.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TADA2B Gene


neXtProt entry for TADA2B Gene

Proteomics data for TADA2B Gene at MOPED

Post-translational modifications for TADA2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TADA2B Gene

No data available for DME Specific Peptides for TADA2B Gene

Domains & Families for TADA2B Gene

Protein Domains for TADA2B Gene

Suggested Antigen Peptide Sequences for TADA2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 SANT domain.
  • Contains 1 ZZ-type zinc finger.
  • Contains 1 SANT domain.
  • Contains 1 ZZ-type zinc finger.
genes like me logo Genes that share domains with TADA2B: view

Function for TADA2B Gene

Molecular function for TADA2B Gene

UniProtKB/Swiss-Prot Function:
Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2.

Gene Ontology (GO) - Molecular Function for TADA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TADA2B: view
genes like me logo Genes that share phenotypes with TADA2B: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TADA2B Gene

Localization for TADA2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TADA2B Gene

Subcellular locations from

Jensen Localization Image for TADA2B Gene COMPARTMENTS Subcellular localization image for TADA2B gene
Compartment Confidence
nucleus 5
cytosol 3
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for TADA2B Gene

Pathways & Interactions for TADA2B Gene

genes like me logo Genes that share pathways with TADA2B: view

Pathways by source for TADA2B Gene

1 BioSystems pathway for TADA2B Gene

Gene Ontology (GO) - Biological Process for TADA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0016573 histone acetylation IBA --
GO:0035066 positive regulation of histone acetylation IBA --
genes like me logo Genes that share ontologies with TADA2B: view

No data available for SIGNOR curated interactions for TADA2B Gene

Drugs & Compounds for TADA2B Gene

No Compound Related Data Available

Transcripts for TADA2B Gene

Unigene Clusters for TADA2B Gene

Transcriptional adaptor 2B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TADA2B Gene

No ASD Table

Relevant External Links for TADA2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TADA2B Gene

mRNA expression in normal human tissues for TADA2B Gene

mRNA differential expression in normal tissues according to GTEx for TADA2B Gene

This gene is overexpressed in Muscle - Skeletal (x4.2).

Protein differential expression in normal tissues from HIPED for TADA2B Gene

This gene is overexpressed in Lung (15.7), Cerebrospinal fluid (6.7), and Urinary Bladder (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TADA2B Gene

SOURCE GeneReport for Unigene cluster for TADA2B Gene Hs.518614

genes like me logo Genes that share expression patterns with TADA2B: view

Protein tissue co-expression partners for TADA2B Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TADA2B Gene

Orthologs for TADA2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TADA2B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TADA2B 35
  • 88.65 (n)
  • 97.14 (a)
-- 36
  • 94 (a)
  • 87 (a)
(Canis familiaris)
Mammalia TADA2B 35
  • 85.57 (n)
  • 95.43 (a)
  • 95 (a)
(Mus musculus)
Mammalia Tada2b 35
  • 88.57 (n)
  • 99.29 (a)
Tada2b 16
Tada2b 36
  • 99 (a)
(Pan troglodytes)
Mammalia TADA2B 35
  • 99.7 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Tada2b 35
  • 88.1 (n)
  • 99.29 (a)
(Monodelphis domestica)
Mammalia TADA2B 36
  • 49 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 88 (a)
-- 36
  • 53 (a)
-- 36
  • 21 (a)
(Gallus gallus)
Aves TADA2B 35
  • 84.6 (n)
  • 95.48 (a)
  • 95 (a)
(Anolis carolinensis)
Reptilia TADA2B 36
  • 94 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tada2b 35
  • 77.38 (n)
  • 91.19 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18623 35
(Danio rerio)
Actinopterygii tada2b 35
  • 76.83 (n)
  • 86.9 (a)
wufb72h11 35
tada2b 36
  • 74 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003109 35
  • 54.68 (n)
  • 45.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ada2b 35
  • 54.17 (n)
  • 44.08 (a)
Ada2b 36
  • 28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ADA2 36
  • 26 (a)
Species with no ortholog for TADA2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TADA2B Gene

Gene Tree for TADA2B (if available)
Gene Tree for TADA2B (if available)

Paralogs for TADA2B Gene

Paralogs for TADA2B Gene

(1) SIMAP similar genes for TADA2B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TADA2B: view

Variants for TADA2B Gene

Sequence variations from dbSNP and Humsavar for TADA2B Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs868489 -- 7,053,526(+) TCCAG(C/T)GGGTG intron-variant
rs870660 -- 7,050,455(+) GCTGG(C/T)GCTGG intron-variant, upstream-variant-2KB
rs907522 -- 7,053,530(-) TTGCC(A/G)CCCGC intron-variant
rs907523 -- 7,051,050(-) GCCCA(C/T)CATCC intron-variant, upstream-variant-2KB
rs907524 -- 7,050,515(-) CGGCC(A/C)CAAGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TADA2B Gene

Variant ID Type Subtype PubMed ID
esv34196 OTHER Inversion 12058347
nsv878530 CNV Loss 21882294
esv34033 CNV Loss 18971310
dgv1568e1 CNV Complex 17122850
nsv428436 CNV Gain 18775914
nsv469847 CNV Complex 16826518
nsv878531 CNV Loss 21882294
nsv878532 CNV Loss 21882294
nsv878533 CNV Loss 21882294
nsv4217 CNV Loss 18451855
esv26516 CNV Loss 19812545

Variation tolerance for TADA2B Gene

Residual Variation Intolerance Score: 15.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.04% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TADA2B Gene

Disorders for TADA2B Gene

Relevant External Links for TADA2B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TADA2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TADA2B Gene

Publications for TADA2B Gene

  1. A novel human Ada2 homologue functions with Gcn5 or Brg1 to coactivate transcription. (PMID: 12972612) Barlev N.A. … Berger S.L. (Mol. Cell. Biol. 2003) 2 3 4 23 67
  2. The STAGA subunit ADA2b is an important regulator of human GCN5 catalysis. (PMID: 18936164) Gamper A.M. … Roeder R.G. (Mol. Cell. Biol. 2009) 2 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PMID: 24163370) Lu L. … Zhang L. (J. Biol. Chem. 2013) 3

Products for TADA2B Gene

Sources for TADA2B Gene