TADA2B Gene
protein-coding GIFtS: 48
GCID: GC04P007043
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transcriptional adaptor 2B
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Aliases
for TADA2B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transcriptional Adaptor 2B1 2 | | MGC218741 | | ADA2B2 3 5 | | ADA2(Beta)1 | | ADA2-Beta1 | | Transcriptional Adapter 2-Beta2 | | ADA2-Like Protein Beta2 3 | | Transcriptional Adaptor 2 (ADA2 Homolog, Yeast)-Beta2 |
Export aliases for TADA2B gene to outside databasesPrevious GC identifers: GC04P007096 GC04P006972 |
Summaries
for TADA2B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TADA2B:
TADA2B functions as a transcriptional adaptor protein that potentiates transcription through coordination of histoneacetyltransferase (HAT) activity and by linking activation factors to basal transcriptional machinery (Barlev et al.,2003 (PubMed 12972612)).(supplied by OMIM, Apr 2010)
UniProtKB/Swiss-Prot: TAD2B_HUMAN, Q86TJ2Function: Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2
|
Genomic Views
for TADA2B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_006051.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TADA2B gene promoter:
ER-alpha Elk-1 AML1a NCX/Ncx Nkx2-5 E47 GATA-1 Evi-1 CREB deltaCREB
Other transcription factors
Search SABiosciences Chromatin IP Primers for TADA2B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TADA2B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p16.1 Ensembl cytogenetic band: 4p16.1 HGNC cytogenetic band: 4p16.1TADA2B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P007043: view genomic region
(about GC identifiers)
Start:
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7,043,626 bp from pter |
End:
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7,059,679 bp from pter |
Size:
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16,054 bases |
Orientation:
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plus strand |
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Proteins
for TADA2B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TAD2B_HUMAN, Q86TJ2 (See
protein sequence)Recommended Name: Transcriptional adapter 2-beta Size: 420 amino acids; 48470 Da
Subunit: Interacts with GCN5L2, SMARCA4, SMARCE1 and PAX5. Component of the TFTC-HAT complex
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAH47794.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence; Sequence=AAI01338.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A0AUJ8 A4QMR7 B3KSN0 B3KU86 Q6MZG9Alternative splicing: 3 isoforms: Q86TJ2-1 Q86TJ2-2 Q86TJ2-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TADA2B: NX_Q86TJ2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86TJ2
TADA2B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689506.2
ENSEMBL proteins: ENSP00000422398 ENSP00000308022 ENSP00000423947 ENSP00000423181 ENSP00000425731
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
TADA2B for ontologies About GeneDecksing
TADA2B Antibody Products:
Assay Products for TADA2B: |
Protein
Domains /
Families
for TADA2B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TADA2B for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q86TJ2ProtoNet protein and cluster: Q86TJ2 1 Blocks protein family: IPB000433 Zn-finger
UniProtKB/Swiss-Prot: TAD2B_HUMAN, Q86TJ2Similarity: Contains 1 SANT domainSimilarity: Contains 1 ZZ-type zinc finger |
Function
for TADA2B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TAD2B_HUMAN, Q86TJ2Function: Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TADA2B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TADA2B |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
TADA2B for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for TADA2B:
|
Pathways & Interactions
for TADA2B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Direct p53 effectors | |
1  BioSystems Pathway for TADA2B
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TADA2B
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/45 Interacting proteins for TADA2B (Q86TJ23 ENSP000003080224) via UniProtKB, MINT, STRING, and/or I2D (see all 45)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- |
TADA2B for ontologies About GeneDecksing
|
Drugs & Compounds
for TADA2B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TADA2B
Search CenterWatch for drugs/clinical trials and news about TADA2B / TAD2B
|
Transcripts
for TADA2B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TADA2B gene: NM_152293.2 Unigene Cluster for TADA2B: Transcriptional adaptor 2B Hs.518614 [show with all ESTs]Unigene Representative Sequence: NM_1522935 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000506692 ENST00000310074(uc003gjw.4 uc010idi.3) ENST00000512388
ENST00000515646(uc021xle.1) ENST00000510704
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TADA2B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TADA2B (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TADA2B (NM_152293) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TADA2B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TADA2B |
Additional cDNA sequence: AK026299.1 AK093974.1 AK096655.1 AK126966.1 BC013164.1 BC047794.1 BC064337.1 BC078156.1 BC101334.1 BC101335.1 BC101336.1 BC101337.2 BX641147.1 BX648428.1 5 DOTS entries: DT.101982425 DT.97771399 DT.100033568 DT.40234811 DT.95262370 24/123 AceView cDNA sequences (see all 123): CD743174 BM699992 CD370689 F02091 BM844330 CK904021 Z40204 BM980519 BU621750 AI299146 BI829835 AW264116 BQ422652 BM707675 AI299860 AW452070 BC064337 BU860474 AI140813 AI609071 AA497090 BF221826 AI862537 AA599233
GeneLoc Exon Structure
|
Expression
for TADA2B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TADA2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCCGCCTGGC
About this image
See TADA2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TADA2B
SOURCE GeneReport for Unigene cluster: Hs.518614
SABiosciences Custom PCR Arrays for TADA2B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TADA2B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TADA2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TADA2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TADA2B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TADA2B |
Orthologs
for TADA2B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TADA2B gene from 9/26 species (see all 26) About this table
ENSEMBL Gene Tree for TADA2B (if available)
TreeFam Gene Tree for TADA2B (if available) |
Paralogs
for TADA2B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TADA2B gene
- TADA2A2
1 SIMAP similar gene for TADA2B using alignment to 3 protein entries: TAD2B_HUMAN (see all proteins):TADA2A
TADA2B for paralogs About GeneDecksing
|
Genomic Variants
for TADA2B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 4 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TADA2B (7043626 - 7059679 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TADA2B
3 CNVs: 68648 3478 47919 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TADA2B |
|
Disorders
/ Diseases
for TADA2B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TADA2B for disorders About GeneDecksing
OMIM gene information: 608790
OMIM disorders: --
1  disease for TADA2B: About MalaCardsmalaria
Human Genome Epidemiology (HuGE) Navigator: TADA2B (1 document)
Export disorders for TADA2B gene to outside databases
|
Publications
for TADA2B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TADA2B gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with TADA2B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel human Ada2 homologue functions with Gcn5 or Brg1 to coactivate transcription. (PubMed id 12972612)1, 2, 3, 9 Barlev N.A.... Berger S.L. (2003)
- The STAGA subunit ADA2b is an important regulator of human GCN5 catalysis. (PubMed id 18936164)1, 3, 9 Gamper A.M....Roeder R.G. (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Activator-Mediator binding regulates Mediator-cofacto r interactions. (PubMed id 20534441)1 Ebmeier C.C. and Taatjes D.J. (2010)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein. (PubMed id 18838386)1 Wang Y.L....Martinez E. (2008)
|
External Searches for TADA2B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TADA2B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TADA2B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TADA2B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TADA2B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TADA2B gene:
Search GeneIP for patents involving TADA2B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TADA2B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TADA2B | | | Browse OriGene 29mer shRNA kits in GFP-retroviral vector | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TADA2B | | | OriGene Protein Over-expression Lysate for TADA2B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TADA2B | | OriGene 3'-UTR Clone for TADA2B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TADA2B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TADA2B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TADA2B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TADA2B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TADA2B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TADA2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TADA2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TADA2B |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TADA2B |
|  |  |  | | | | Search ThermoFisher Antibodies for TADA2B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TADA2B |
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