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Aliases for TADA2B Gene

Aliases for TADA2B Gene

  • Transcriptional Adaptor 2B 2 3
  • ADA2B 3 4 6
  • ADA2-Like Protein Beta 3 4
  • ADA2-Beta 3 4
  • Transcriptional Adaptor 2 (ADA2 Homolog, Yeast)-Beta 3
  • Transcriptional Adapter 2-Beta 3
  • ADA2(Beta) 3

External Ids for TADA2B Gene

Previous GeneCards Identifiers for TADA2B Gene

  • GC04P007096
  • GC04P006972

Summaries for TADA2B Gene

Entrez Gene Summary for TADA2B Gene

  • TADA2B functions as a transcriptional adaptor protein that potentiates transcription through coordination of histone acetyltransferase (HAT) activity and by linking activation factors to basal transcriptional machinery (Barlev et al., 2003 [PubMed 12972612]).[supplied by OMIM, Apr 2010]

GeneCards Summary for TADA2B Gene

TADA2B (Transcriptional Adaptor 2B) is a Protein Coding gene. Among its related pathways are Direct p53 effectors and RNA Polymerase I Promoter Opening. GO annotations related to this gene include chromatin binding.

UniProtKB/Swiss-Prot for TADA2B Gene

  • Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TADA2B Gene

Genomics for TADA2B Gene

Regulatory Elements for TADA2B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TADA2B Gene

Start:
7,041,899 bp from pter
End:
7,057,952 bp from pter
Size:
16,054 bases
Orientation:
Plus strand

Genomic View for TADA2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TADA2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TADA2B Gene

Proteins for TADA2B Gene

  • Protein details for TADA2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TJ2-TAD2B_HUMAN
    Recommended name:
    Transcriptional adapter 2-beta
    Protein Accession:
    Q86TJ2
    Secondary Accessions:
    • A0AUJ8
    • A4QMR7
    • B3KSN0
    • B3KU86
    • Q6MZG9

    Protein attributes for TADA2B Gene

    Size:
    420 amino acids
    Molecular mass:
    48470 Da
    Quaternary structure:
    • Interacts with GCN5L2, SMARCA4, SMARCE1 and PAX5. Component of the TFTC-HAT complex.
    SequenceCaution:
    • Sequence=AAH47794.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI01338.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TADA2B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TADA2B Gene

Proteomics data for TADA2B Gene at MOPED

Post-translational modifications for TADA2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TADA2B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TADA2B Gene

Domains for TADA2B Gene

Protein Domains for TADA2B Gene

Suggested Antigen Peptide Sequences for TADA2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86TJ2

UniProtKB/Swiss-Prot:

TAD2B_HUMAN :
  • Q86TJ2
Domain:
  • Contains 1 SANT domain.
Similarity:
  • Contains 1 ZZ-type zinc finger.
genes like me logo Genes that share domains with TADA2B: view

No data available for Gene Families for TADA2B Gene

Function for TADA2B Gene

Molecular function for TADA2B Gene

UniProtKB/Swiss-Prot Function: Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2.

Gene Ontology (GO) - Molecular Function for TADA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TADA2B: view

Phenotypes for TADA2B Gene

genes like me logo Genes that share phenotypes with TADA2B: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TADA2B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TADA2B Gene

Localization for TADA2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TADA2B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TADA2B Gene COMPARTMENTS Subcellular localization image for TADA2B gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for TADA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030914 STAGA complex IEA --
GO:0070461 SAGA-type complex IDA 18838386
genes like me logo Genes that share ontologies with TADA2B: view

Pathways for TADA2B Gene

genes like me logo Genes that share pathways with TADA2B: view

Pathways by source for TADA2B Gene

1 BioSystems pathway for TADA2B Gene

Gene Ontology (GO) - Biological Process for TADA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TADA2B: view

Transcripts for TADA2B Gene

Unigene Clusters for TADA2B Gene

Transcriptional adaptor 2B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TADA2B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TADA2B Gene

No ASD Table

Relevant External Links for TADA2B Gene

GeneLoc Exon Structure for
TADA2B
ECgene alternative splicing isoforms for
TADA2B

Expression for TADA2B Gene

mRNA expression in normal human tissues for TADA2B Gene

mRNA differential expression in normal tissues according to GTEx for TADA2B Gene

This gene is overexpressed in Muscle - Skeletal (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TADA2B Gene

SOURCE GeneReport for Unigene cluster for TADA2B Gene Hs.518614

genes like me logo Genes that share expressions with TADA2B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TADA2B Gene

Orthologs for TADA2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TADA2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TADA2B 35
  • 99.7 (n)
  • 100 (a)
TADA2B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 94 (a)
OneToMany
TADA2B 35
  • 88.65 (n)
  • 97.14 (a)
TADA2B 36
  • 87 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TADA2B 35
  • 85.57 (n)
  • 95.43 (a)
TADA2B 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tada2b 35
  • 88.57 (n)
  • 99.29 (a)
Tada2b 16
Tada2b 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TADA2B 36
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 88 (a)
OneToMany
-- 36
  • 53 (a)
OneToMany
-- 36
  • 21 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tada2b 35
  • 88.1 (n)
  • 99.29 (a)
chicken
(Gallus gallus)
Aves TADA2B 35
  • 84.6 (n)
  • 95.48 (a)
TADA2B 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TADA2B 36
  • 94 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.18623 35
tropical clawed frog
(Silurana tropicalis)
Amphibia tada2b 35
  • 77.38 (n)
  • 91.19 (a)
zebrafish
(Danio rerio)
Actinopterygii tada2b 35
  • 76.83 (n)
  • 86.9 (a)
tada2b 36
  • 74 (a)
OneToOne
wufb72h11 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003109 35
  • 54.68 (n)
  • 45.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ada2b 35
  • 54.17 (n)
  • 44.08 (a)
Ada2b 36
  • 28 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ADA2 36
  • 26 (a)
OneToMany
Species with no ortholog for TADA2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TADA2B Gene

ENSEMBL:
Gene Tree for TADA2B (if available)
TreeFam:
Gene Tree for TADA2B (if available)

Paralogs for TADA2B Gene

Selected SIMAP similar genes for TADA2B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TADA2B: view

No data available for Paralogs for TADA2B Gene

Variants for TADA2B Gene

Sequence variations from dbSNP and Humsavar for TADA2B Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs868489 -- 7,053,526(+) TCCAG(C/T)GGGTG intron-variant
rs870660 -- 7,050,455(+) GCTGG(C/T)GCTGG intron-variant
rs907522 -- 7,053,530(-) TTGCC(A/G)CCCGC intron-variant
rs907523 -- 7,051,050(-) GCCCA(C/T)CATCC intron-variant
rs907524 -- 7,050,515(-) CGGCC(A/C)CAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TADA2B Gene

Variant ID Type Subtype PubMed ID
esv34196 OTHER Inversion 12058347
nsv878530 CNV Loss 21882294
esv34033 CNV Loss 18971310
dgv1568e1 CNV Complex 17122850
nsv428436 CNV Gain 18775914
nsv469847 CNV Complex 16826518
nsv878531 CNV Loss 21882294
nsv878532 CNV Loss 21882294
nsv878533 CNV Loss 21882294
nsv4217 CNV Loss 18451855
esv26516 CNV Loss 19812545

Relevant External Links for TADA2B Gene

HapMap Linkage Disequilibrium report
TADA2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TADA2B Gene

Disorders for TADA2B Gene

Relevant External Links for TADA2B

Genetic Association Database (GAD)
TADA2B
Human Genome Epidemiology (HuGE) Navigator
TADA2B
genes like me logo Genes that share disorders with TADA2B: view

No data available for UniProtKB/Swiss-Prot for TADA2B Gene

Publications for TADA2B Gene

  1. A novel human Ada2 homologue functions with Gcn5 or Brg1 to coactivate transcription. (PMID: 12972612) Barlev N.A. … Berger S.L. (Mol. Cell. Biol. 2003) 2 3 4 23
  2. The STAGA subunit ADA2b is an important regulator of human GCN5 catalysis. (PMID: 18936164) Gamper A.M. … Roeder R.G. (Mol. Cell. Biol. 2009) 2 3 23
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  5. Activator-Mediator binding regulates Mediator-cofactor interactions. (PMID: 20534441) Ebmeier C.C. … Taatjes D.J. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3

Products for TADA2B Gene

Sources for TADA2B Gene

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