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TADA2A Gene

protein-coding   GIFtS: 60
GCID: GC17P035767

Transcriptional Adaptor 2A

(Previous names: transcriptional adaptor 2 (ADA2 homolog, yeast)-like)
(Previous symbol: TADA2L)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transcriptional Adaptor 2A1 2     ADA22
TADA2L1 2 3 5     hADA22
ADA2-Like Protein2 3     Transcriptional Adapter 2-Alpha2
ADA2A2 5     Transcriptional Adaptor 2 Alpha2
Transcriptional Adaptor 2 (ADA2 Homolog, Yeast)-Like1     Transcriptional Adapter 2-Like3

External Ids:    HGNC: 115311   Entrez Gene: 68712   Ensembl: ENSG000001082647   OMIM: 6022765   UniProtKB: O754783   

Export aliases for TADA2A gene to outside databases

Previous GC identifers: GC17P032842 GC17P031705


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TADA2A Gene:
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene
transcription by interacting functionally with the general transcription machinery bound at the basal promoter.
Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes,
thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional
activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively
spliced transcript variants encoding different isoforms of this gene have been described, but the full-length
nature of some of these variants has not been determined. (provided by RefSeq, Oct 2009)

GeneCards Summary for TADA2A Gene:
TADA2A (transcriptional adaptor 2A) is a protein-coding gene. Diseases associated with TADA2A include tuberculous empyema, and pleural tuberculosis. GO annotations related to this gene include transcription cofactor activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is TADA2B.

UniProtKB/Swiss-Prot: TAD2A_HUMAN, O75478
Function: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Required for the function of some acidic activation domains, which activate transcription from a distant site (By
similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring
nucleosomes. Plays a role in chromatin remodeling

Gene Wiki entry for TADA2A (TADA2L) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NT_010783.16  NT_187614.1  NC_018928.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TADA2A
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTADA2A promoter sequence
   Search Chromatin IP Primers for TADA2A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TADA2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q12-q21   Ensembl cytogenetic band:  17q12   HGNC cytogenetic band: 17q12-q21

TADA2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TADA2A gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P035767:  view genomic region     (about GC identifiers)

Start:
35,766,965 bp from pter      End:
35,839,835 bp from pter
Size:
72,871 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TAD2A_HUMAN, O75478 (See protein sequence)
Recommended Name: Transcriptional adapter 2-alpha  
Size: 443 amino acids; 51506 Da
Subunit: Interacts with GCN5 and NR3C1. Associated with the P/CAF protein in the PCAF complex. Component of the
PCAF complex, at least composed of TADA2L/ADA2, TADA3L/ADA3, TAF5L/PAF65-beta, TAF6L/PAF65-alpha, TAF10/TAFII30,
TAF12/TAFII20, TAF9/TAFII31 and TRRAP. Component of the ADA2A-containing complex (ATAC), composed of CSRP2BP,
KAT2A, TADA2L, TADA3L, ZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1
1 PDB 3D structure from and Proteopedia for TADA2A:
1X41 (3D)    
Secondary accessions: A8MVD0 B3KMU9 Q9BVJ0 Q9UCW2 Q9UP49
Alternative splicing: 2 isoforms:  O75478-1   O75478-2   

Explore the universe of human proteins at neXtProt for TADA2A: NX_O75478

Explore proteomics data for TADA2A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys132, Lys398, Lys407
  • Modification sites at PhosphoSitePlus

  • See TADA2A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001159577.1  NP_001479.3  NP_597683.2  

    ENSEMBL proteins: 
     ENSP00000377918   ENSP00000465521   ENSP00000465580   ENSP00000432503   ENSP00000466884  
     ENSP00000225396   ENSP00000468136   ENSP00000466468   ENSP00000465358   ENSP00000406699  
    Reactome Protein details: O75478

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR017884 SANT_dom
     IPR001005 SANT/Myb
     IPR016827 Transcriptional_adaptor_2
     IPR009057 Homeodomain-like
     IPR007526 SWIRM

    Graphical View of Domain Structure for InterPro Entry O75478

    ProtoNet protein and cluster: O75478

    2 Blocks protein domains:
    IPB000433 Zn-finger
    IPB007526 SWIRM


    UniProtKB/Swiss-Prot: TAD2A_HUMAN, O75478
    Similarity: Contains 1 SANT domain
    Similarity: Contains 1 SWIRM domain


    TADA2A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TAD2A_HUMAN, O75478
    Function: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
    Required for the function of some acidic activation domains, which activate transcription from a distant site (By
    similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring
    nucleosomes. Plays a role in chromatin remodeling

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8552087
    GO:0003712transcription cofactor activity TAS8552087
    GO:0004402contributes to histone acetyltransferase activity IDA9674425
         
    TADA2A for ontologies           About GeneDecksing


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TAD2A_HUMAN, O75478: Nucleus. Chromosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    cytosol2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000125PCAF complex IDA9674425
    GO:0005634nucleus TAS8552087
    GO:0005671Ada2/Gcn5/Ada3 transcription activator complex IEA--
    GO:0005694chromosome IEA--
    GO:0072686mitotic spindle IEA--

    TADA2A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TADA2A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1RNA Polymerase I Promoter Opening
    HATs acetylate histones0.34
    Chromatin organization0.34
    Chromatin modifying enzymes0.34
    2Transcription Ligand Dependent Transcription of Retinoid Target genes
    Transcription Ligand Dependent Transcription of Retinoid Target genes

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for TADA2A
        Transcription Ligand-Dependent Transcription of Retinoid-Target genes


    1 Reactome Pathway for TADA2A
        HATs acetylate histones



    TADA2A for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TADA2A
    Interactions:

        Search GeneGlobe Interaction Network for TADA2A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TADA2A (O754782, 3 ENSP000002253964) via UniProtKB, MINT, STRING, and/or I2D (see all 444)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC101Q96ES72, 3, ENSP000003161144MINT-8012377 I2D: score=2 STRING: ENSP00000316114
    MED1Q156482, 3, ENSP000003006514MINT-7985641 I2D: score=1 STRING: ENSP00000300651
    ENSG00000233049O602313, ENSP000004089564I2D: score=1 STRING: ENSP00000408956
    DDX39BQ138383I2D: score=1 
    DHX16O602313I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001932regulation of protein phosphorylation IEA--
    GO:0006325chromatin organization TAS--
    GO:0006366transcription from RNA polymerase II promoter TAS8552087
    GO:0007067mitosis IEA--
    GO:0031063regulation of histone deacetylation IEA--

    TADA2A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TADA2A (TAD2A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TADA2A gene (3 alternative transcripts): 
    NM_001166105.1  NM_001488.3  NM_133439.2  

    Unigene Cluster for TADA2A:

    Transcriptional adaptor 2A
    Hs.500066  [show with all ESTs]
    Unigene Representative Sequence: AK225918
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394395(uc002hnt.3 uc002hnw.3) ENST00000585341 ENST00000589153
    ENST00000587420 ENST00000490992(uc002hnv.3) ENST00000587211 ENST00000586023
    ENST00000225396 ENST00000590005 ENST00000590957 ENST00000589849 ENST00000591992
    ENST00000587593 ENST00000591933 ENST00000591335 ENST00000588405 ENST00000417170(uc002hnu.1)

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    Additional mRNA sequence: 

    AF064094.1 AF069732.1 AK022767.1 AK096371.1 AK225918.1 BC001172.1 BC011753.2 

    15 DOTS entries:

    DT.40311061  DT.100652497  DT.100023091  DT.100023092  DT.100724658  DT.429448  DT.100654330  DT.439866 
    DT.95273699  DT.100774204  DT.120931017  DT.91759608  DT.91811353  DT.95105280  DT.120930924 

    Selected AceView cDNA sequences (see all 112):

    AA297862 CF529493 R74011 BX370711 AA809900 AI968140 AI220840 BI333991 
    AA856985 BC011753 CR615572 AI000805 CB215685 AL526501 BQ068240 BQ187943 
    AW298572 BI910656 AL582905 AK123123 BM917565 BG427977 AF069732 AK096371 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TADA2A (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^
    SP1:                                                  -     -                                   -                 -                                             
    SP2:                                                                                            -                 -                                             
    SP3:                                                  -     -                                   -                                                               
    SP4:        -     -                                         -                                                                                                   
    SP5:        -     -                                                                                                                                             

    ExUns: 19
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for TADA2A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TADA2A expression in normal human tissues (normalized intensities)      TADA2A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTCTGTTAT
    TADA2A Expression
    About this image


    TADA2A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Ovary (Reproductive System)
             Secondary Oocyte Antral Follicle
     
     Gonad
             Secondary Oocyte Antral Follicle
    TADA2A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TADA2A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.500066

    UniProtKB/Swiss-Prot: TAD2A_HUMAN, O75478
    Tissue specificity: Expressed in all tissues, but most abundantly in testis

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TADA2A gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tada2a1 , 5 transcriptional adaptor 2A1, 5 90.67(n)1
    97.07(a)1
      11 (51.29 cM)5
    2170311  NM_172562.31  NP_766150.11 
     840789205 
    chicken
    (Gallus gallus)
    Aves TADA2A1 transcriptional adaptor 2A 81.04(n)
    90.52(a)
      417656  NM_001012807.1  NP_001012825.1 
    lizard
    (Anolis carolinensis)
    Reptilia TADA2A6
    transcriptional adaptor 2A
    91(a)
    1 ↔ 1
    GL343439.1(51716-67542)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.106062 Transcribed sequence with moderate similarity to protein more 78.47(n)    141995457 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.126572 Transcribed sequence with moderate similarity to protein more 74.56(n)    BM141440.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ada2a1 Ada2a 44.31(n)
    38.66(a)
      326128  NM_001014635.3  NP_001014635.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ADA2(YDR448W)4
    ADA21
    Transcription coactivator, component of the ADA and more4
    ADA21
    44.18(n)1
    31.1(a)1
      4(1356065-1357369)4
    8520591, 4  NP_010736.31  NP_010736.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ADA2B1 ADA2B 46.25(n)
    34.63(a)
      827336  NM_202831.2  NP_974560.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g07508001 Os03g0750800 46.07(n)
    33.75(a)
      4334126  NM_001057822.1  NP_001051287.1 


    ENSEMBL Gene Tree for TADA2A (if available)
    TreeFam Gene Tree for TADA2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TADA2A gene
    TADA2B2  
    1 SIMAP similar gene for TADA2A using alignment to 6 protein entries:     TAD2A_HUMAN (see all proteins):
    TADA2B

    TADA2A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TADA2A (see all 1427)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs795231581,2
    --35768920(+) GACCTA/CCCCCA 3 -- int10--------
    rs571077031,2
    C--35768926(+) CCCCAC/ACCCAA 3 -- int12Minor allele frequency- A:0.06WA 120
    rs1846213001,2
    --35769084(+) TTAGTC/TCACTA 3 -- int10--------
    rs118712751,2
    C,F,H--35769089(+) CCACTA/TCTATG 3 -- int118Minor allele frequency- T:0.18NS EA NA WA CSA 936
    rs112637481,2
    C,H--35769211(+) ACTGTC/TGCCCA 3 -- int18Minor allele frequency- T:0.06NA CSA 17
    rs1875290581,2
    --35769253(+) CTGCAA/GCCTCC 3 -- int10--------
    rs1426935581,2
    --35769322(+) CGCCCA/GCCACC 3 -- int10--------
    rs1920425821,2
    --35769383(+) GTTGCC/TCAGGC 3 -- int10--------
    rs1841910001,2
    --35769555(+) GCCAGA/GTAAAA 3 -- int10--------
    rs1507304721,2
    C--35769726(+) GCCCGC/TGCCTG 3 -- int10--------

    HapMap Linkage Disequilibrium report for TADA2A (35766965 - 35839835 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for TADA2A:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv550e199CNV Deletion23128226
    esv2715889CNV Deletion23290073
    dgv549e199CNV Deletion23128226
    nsv435684CNV Deletion17901297
    esv2661747CNV Deletion23128226
    dgv524n67CNV Loss20364138
    nsv9543CNV Loss18304495
    esv1010097CNV Gain20482838
    dgv955e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TADA2A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602276    OMIM disorders: --

    10 diseases for TADA2A:    About MalaCards
    tuberculous empyema    pleural tuberculosis    congenital diaphragmatic hernia    retinal degeneration
    tuberculosis    retinitis    lymphoblastic leukemia    thyroiditis
    leukemia    ovarian cancer

    1 disease from the University of Copenhagen DISEASES database for TADA2A:
    Congenital diaphragmatic hernia

    TADA2A for disorders           About GeneDecksing

    Genetic Association Database (GAD): TADA2A
    Human Genome Epidemiology (HuGE) Navigator: TADA2A (1 document)

    Export disorders for TADA2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TADA2A gene, integrated from 10 sources (see all 43):
    (articles sorted by number of sources associating them with TADA2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5. (PubMed id 8552087)1, 2, 3 Candau R....Berger S.L. (Mol. Cell. Biol. 1996)
    2. Role of the Ada adaptor complex in gene activation by the glucocorticoid receptor. (PubMed id 9154805)1, 2, 9 Henriksson A....Wright A.P.H. (Mol. Cell. Biol. 1997)
    3. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Histone-like TAFs within the PCAF histone acetylase complex. (PubMed id 9674425)1, 2 Ogryzko V.V.... Nakatani Y. (Cell 1998)
    7. The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily. (PubMed id 9885574)1, 2 Vassilev A.... Nakatani Y. (Mol. Cell 1998)
    8. A novel human Ada2 homologue functions with Gcn5 or Brg1 to coactivate transcription. (PubMed id 12972612)1, 9 Barlev N.A.... Berger S.L. (Mol. Cell. Biol. 2003)
    9. Role of important hydrophobic amino acids in the interaction between the glucocorticoid receptor tau 1-core activation domain and target factors. (PubMed id 9649342)1, 9 AlmlAPf T....Wright A.P. (Biochemistry 1998)
    10. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). (PubMed id 23503679)1 Zhu J....Elledge S.J. (Nat. Biotechnol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 6871 HGNC: 11531 AceView: TADA2L Ensembl:ENSG00000108264 euGenes: HUgn6871
    ECgene: TADA2A H-InvDB: TADA2A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TADA2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TADA2A gene:
    Search GeneIP for patents involving TADA2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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